University of Gttingen device points towards more efficient treatments.
Cochlear implants are an established treatment, using a microphone to detect sound and converting that sound into electrical impulses, split into several channels for different frequency ranges. Electrode contacts, typically 12 to 24 in number, then deliver the electrical impulses to the ganglion neurons of the cochlea.
But these devices can offer poor quality sound encoding, partly due to the large lateral spread of electrical current from each electrode, stimulating too many auditory neurons at the same time. A project at the University of Gttingen has now developed a light-based alternative device, reported in Science Translational Medicine.
"The lateral spread is considered the major bottleneck of electrical implants," said Tobias Moser of the University of Gttingnen. "Despite efforts such as multipolar stimulation and current steering, it seems hard or even impossible to overcome."
Neurons are not typically light sensitive, although the growing field of optogenetics has found elegant ways to induce neurons into expressing light-sensitive proteins through genetic modifications in so-called transgenic animals, and making the neurons react to illumination by laser pulse.
Since light can be better confined in space than electric current, optogenetic techniques could allow cochlea stimulation to be made more efficient. However, light sources for optogenetics have usually been individual GaN-based LEDs and optical fibers coupled to external lasers.
In designing an optical cochlear implant (oCI) for auditory treatment and future clinical translation, the Gttingen project had to develop multichannel devices suitable for this very specific purpose.
The eventual design featured a linear array of 10 LED chips, each 270 by 220 microns and emitting at 457 nanometers, integrated onto microfabricated 15-micron-thick polyimide-based carriers with interconnecting lines to address individual LEDs.
"The linear array of 10 LEDs at the oCI tip was designed with a pitch of 500 or 350 microns," noted the project in its published paper. "In addition, an array with four LEDs containing a temperature sensor integrated beneath the first LED chip enables a precise resistance measurement, and thus allows monitoring of potential temperature increase inside the implant."
Having optimized the design for rodent ears, the project inserted the device into transgenic rats and characterized the oCI's stimulation of the animals' auditory nerves. Comparing the spatial spread of excitation from the LEDs of the oCI to that from electrodes of a conventional electrical implant by monitoring the animal's midbrain allowed the frequency selectivity of the oCI device to be characterized.
In behavioral experiments, the team began with rats with normal hearing and trained them to perform a behavior driven by sound. After deafening the rats, the team implanted the oCI device and found that the animals could still perform the acoustically trained behavior with the aid of the multichannel implant.
According to the project, results showed that use of gene therapy and the optical implant in conjunction led to an improved frequency selectivity compared with the electrical alternative, and future enhancements to both the size of LEDs and the spread of light from each emitter could enhance this parameter further.
Although further work will be needed before clinical trails using the device can start, including more detailed studies of behavioral analysis connected with the technique, the team has founded a spin-out company, OptoGenTech, to potentially assist translation of the gene therapy and oCI combination into a human clinical trial and, eventually, bring it to market.
"This is the first demonstration and characterization of preclinical hearing restoration by a complete multichannel oCI system based on LEDs," commented Moser.
- Reducing barriers to mainstream gene therapy - BioPharma-Reporter.com - September 4th, 2020
- Mapping Genetic Diversity of Lung Tumors Over Time May Lead to More Effective Therapies - UCSF News Services - September 4th, 2020
- Multi-site study to evaluate the role of testing guidelines in ensuring access to genetic information for men with prostate cancer - PRNewswire - September 4th, 2020
- Global Prime Editing Market to Witness Heightened Growth During the Period 2020 2030 - The Daily Chronicle - September 4th, 2020
- Liquid biopsies to disrupt the oncology testing market - Medical Device Network - September 4th, 2020
- Global RNA-interference (RNAi) Market Growth, Trends and Forecasts to 2025: Focus on Key Players Alnylam Pharmaceuticals, Arrowhead, Quark... - September 4th, 2020
- Yale researchers find a cause and possible treatment for Fragile X - Yale News - September 4th, 2020
- 'Coming into their own': FDA approval of liquid biopsy tests puts early, less invasive cancer detection in broader reach - USA TODAY - September 4th, 2020
- Fusion Genes Associated With More Aggressive Papillary Thyroid Cancer in Pediatric Patients - Targeted Oncology - September 4th, 2020
- Existing Class of Drugs May Improve Neurological Function in Patients with Rare, Aggressive Genetic Disorder - Newswise - September 4th, 2020
- Genomic analysis reveals insights on virulent, emerging foodborne pathogen - UB Now: News and views for UB faculty and staff - University at Buffalo... - September 4th, 2020
- Hyperthyroidism is associated with breast cancer risk and mammographic and genetic risk predictors - 2 Minute Medicine - September 4th, 2020
- Health history platform launches to trace genetic conditions | Digital Healthcare - Healthcare Global - Healthcare News, Magazine and Website - September 4th, 2020
- New HIV Gene Therapy, CAR-T Treatments Could be on the Horizon for Patients - BioSpace - September 4th, 2020
- Cell Suicide Gene Further Linked to Immunotherapy Response - Technology Networks - September 2nd, 2020
- Genetic mutations may be linked to infertility, early menopause - Washington University School of Medicine in St. Louis - September 2nd, 2020
- How to use precision medicine to personalise COVID-19 treatment according to the patient's genes - Down To Earth Magazine - September 2nd, 2020
- UCT professors research offers hope of treatment for sickle cell anaemia - Daily Maverick - September 2nd, 2020
- Association of recent stressful life events with mental and physical health in the context of genomic and exposomic liability for schizophrenia - 2... - September 2nd, 2020
- Finding order in the chaos of cancer mutations - Drug Target Review - September 2nd, 2020
- Mustang Bio Announces Orphan Drug Designation for MB-107 for the Treatment of X-linked Severe Combined Immunodeficiency in Newly Diagnosed Infants -... - September 2nd, 2020
- Novavax Announces Publication of Phase 1 Data for COVID-19 Vaccine Candidate in The New England Journal of Medicine - GlobeNewswire - September 2nd, 2020
- Department of Genetic Medicine | Johns Hopkins Medicine - August 10th, 2020
- Genetic Medicine | Internal Medicine | Michigan Medicine ... - August 10th, 2020
- Genetic Medicine | Department of Medicine - August 10th, 2020
- Genomics and Medicine - Genome.gov - August 10th, 2020
- New Approach to Treating Osteoarthritis Advances | NYU Langone News - NYU Langone Health - August 10th, 2020
- Stoke Therapeutics Reports Second Quarter Financial Results and Provides Business Updates - Business Wire - August 10th, 2020
- Here's Why Shares of Editas Medicine and Beam Therapeutics Are Soaring Today - Motley Fool - August 10th, 2020
- Grant will fund study into COVID outcome disparities in NYC - Cornell Chronicle - August 10th, 2020
- A versatile genetic control system in mammalian cells and mice responsive to clinically licensed sodium ferulate - Science Advances - August 10th, 2020
- Spark Therapeutics Deepens Drug Development Expertise in Hematology and Rare Disease with Appointment of Gallia G. Levy, MD, Ph.D., as Chief Medical... - August 10th, 2020
- Chromosomal Rearrangements Associated with Chemotherapeutic Drug Resistance | McDonnell Boehnen Hulbert & Berghoff LLP - JD Supra - August 10th, 2020
- Jae Jung, Ph.D., Appointed as Chair of Cleveland Clinic Lerner Research Institute's Department of Cancer Biology - Health Essentials from Cleveland... - August 10th, 2020
- The UK and TCELS to jointly support COVID-19 research in Thailand - GOV.UK - August 10th, 2020
- Akouos Announces Expansion of Executive Team and Board of Directors - BioSpace - August 10th, 2020
- Medical and neurobehavioural phenotypes in male and female carriers of Xp22.31 duplications in the UK Biobank. - Physician's Weekly - August 10th, 2020
- Coronavirus vaccine breakthrough: New generation cure that stops virus developed - Express - August 10th, 2020
- Global Cell and Gene Therapy Market, Forecast to 2025 by Product, Disease, End-user and Region - COVID-19 Updated - PRNewswire - August 10th, 2020
- Not Everyone Needs 8 Hours of Sleep, New Research Reveals | Time - TIME - August 10th, 2020
- Lindsey Criswell Named Director of National Institute of Arthritis and Musculoskeletal and Skin Diseases - UCSF News Services - August 10th, 2020
- Pinpointing The Cells That Keep The Bodys Master Circadian Clock Ticking - Newswise - August 10th, 2020
- Kazia Therapeutics hits A$1 on grant of Rare Pediatric Disease Designation to paxalisib for DIPG - Proactive Investors USA & Canada - August 10th, 2020
- Treatment Considerations for Prostate Cancer Progressing After Combination Therapy for mCSPC - UroToday - August 10th, 2020
- Edited Transcript of PSNL.OQ earnings conference call or presentation 6-Aug-20 9:00pm GMT - Yahoo Finance - August 10th, 2020
- Ovid and Angelini partner on treating Angelman syndrome in Europe - Pharmaceutical Technology - August 10th, 2020
- Doctoral Student/Research Assistant in Mitochondrial Biology and Signalling job with UNIVERSITY OF HELSINKI | 218596 - Times Higher Education (THE) - August 10th, 2020
- Simpler COVID-19 test could provide results in hours from saliva - University of Wisconsin-Madison - August 10th, 2020
- This company has a better version of a simpler, faster Covid-19 test - STAT - August 7th, 2020
- Mental Notes: Music Cognition Lab is dedicated to the scientific study of how music affects the brain and behavior - Vanderbilt University News - August 6th, 2020
- Nasha Fitter Elected to Board of Directors of the ACMG Foundation for Genetic and Genomic Medicine - PRNewswire - August 5th, 2020
- HDAC6 Can Control Tumor Growth and Halt Metastasis in Triple-Negative Breast Cancer - Newswise - August 5th, 2020
- Will programming a cell ever be as easy as programming an app? - SynBioBeta - August 5th, 2020
- Penn Researchers Identify New Genetic Cause of a Form of Inherited Neuropathy - Newswise - August 5th, 2020
- Genetic Variant in Persons of African Descent Linked with Stroke: Analysis - DocWire News - August 5th, 2020
- Invitae Reports $46.2 Million in Revenue Driven by More Than 120000 Samples Accessioned in the Second Quarter of 2020 - Monterey County Weekly - August 5th, 2020
- Noel R. Rose, widely regarded as the father of autoimmune disease research, dies at 92 - The Hub at Johns Hopkins - August 5th, 2020
- Atsena Therapeutics acquires exclusive rights to Gene Therapy for GUCY2D-associated Leber Congenital Amaurosis - GlobeNewswire - August 5th, 2020
- Seragon Announces GenomeScore, the First AI Platform to Measure Rate of Aging and Physiological Changes - PRNewswire - August 5th, 2020
- Vaccine 'durability': COVID-19 immunizations coming soon but will they last? - Genetic Literacy Project - August 5th, 2020
- Aerpio Pharmaceuticals, Inc. Announces a Second Clinical Trial with Funding from MTEC to Evaluate Razuprotafib for the Prevention and Treatment of... - August 5th, 2020
- Stoke Therapeutics to Present at Upcoming Investor Conferences in August - Business Wire - August 4th, 2020
- The global cell and gene therapy market by revenue is expected to grow at a CAGR of over 30.90% during the period 20192025 - GlobeNewswire - August 4th, 2020
- Rozlytrek, Roche's first tumour-agnostic therapy, approved in Europe for people with NTRK fusion-positive solid tumours and for people with... - August 4th, 2020
- Alnylam Pharmaceuticals : Submits CTA Application for ALN-HSD, an Investigational RNAi Therapeutic for the Treatment of Nonalcoholic Steatohepatitis -... - August 4th, 2020
- 'The younger the child, the likelier to find causative gene of infant epilepsy' - Korea Biomedical Review - Korea Biomedical Review - August 3rd, 2020
- Known genes associated with male infertility doubled - BioNews - August 3rd, 2020
- Alnylam Submits CTA Application for ALN-HSD, an Investigational RNAi Therapeutic for the Treatment of Nonalcoholic Steatohepatitis (NASH) - Business... - August 3rd, 2020
- Cancer drug is first therapy to emerge from 23andMe-GSK deal - STAT - STAT - August 3rd, 2020
- Dr. Rana on the Rationale for Video Genetic Counseling in Prostate Cancer - OncLive - August 3rd, 2020
- Metastatic Lung Cancer Study Finds That Bionano's Saphyr Outperforms NGS for the Detection of Structural Variants - GlobeNewswire - August 3rd, 2020
- Health Media in the COVID-19 Era: A mid-wave report - Features - MM&M - Medical Marketing and Media - August 3rd, 2020
- Cyberpunk 2077 shows off the ruined dreams district of Pacifica in new concept art - Critical Hit - August 2nd, 2020
- An unsupported American conspiracy theory found a foothold in Europe. New research shows how - NewsDio - August 2nd, 2020
- Study Suggests New Approach to Improve Radiation Therapy Resistance in Glioblastoma - Michigan Medicine - August 1st, 2020
- Atsena Therapeutics acquires exclusive rights to Gene Therapy for GUCY2D-associated Leber Congenital Amaurosis - BioSpace - August 1st, 2020
- Our Genes May Explain Severity of COVID-19 and Other Infections - Quanta Magazine - August 1st, 2020
- Omega Therapeutics Lands $85M to Tap Into Control Room of Biology - Xconomy - August 1st, 2020
- EarlyBird Study: Early Detection of Adult-Onset Type 2 Diabetes in Youth - Diabetes In Control - August 1st, 2020
- Movers & Shakers, July 24 | BioSpace - BioSpace - July 31st, 2020