Genetic engineering in science fiction – Wikipedia

In literature and especially in science fiction, genetic engineering has been used as a theme or a plot device in many stories.[1][2]

In his 1924 essay Daedalus, or Science and the Future, J. B. S. Haldane predicted a day when biologists would invent new algae to feed the world and ectogenetic children would be created and modified using eugenic selection. Aldous Huxley developed these ideas in a satirical direction for his 1932 novel Brave New World, in which ectogenetic embryos were developed in selected environments to create children of an ‘Alpha’, ‘Beta’, or ‘Gamma’ type.[3]

The advent of large-scale genetic engineering has increased its presence in fiction.[4][5] Genetics research consortia, such as the Wellcome Trust Sanger Institute, have felt the need to distinguish genetic engineering fact from fiction in explaining their work to the public,[1] and have explored the role that genetic engineering has played in the public perception of programs, such as the Human Genome Project.[6]

Beyond the usual library catalog classifications,[7] the Wellcome Trust Sanger Institute[1] and the NHGRI[6] have compiled catalogs of literature in various media with genetics and genetic engineering as a theme or plot device. Such compilations are also available at fan sites.[8]

In the 2000 television series Andromeda, the Nietzscheans (Homo sapiens invictus in Latin) are a race of genetically engineered humans who religiously follow the works of Friedrich Nietzsche, social Darwinism and Dawkinite genetic competitiveness. They claim to be physically perfect and are distinguished by bone blades protruding outwards from the wrist area.

In the book 2312 by Kim Stanley Robinson, genetic engineering of humans, plants and animals and how that affects a society spread over the solar system is explored.

In the Animorphs book series, race of aliens known as the Hork-Bajir were engineered by a race known as the Arns. Another race, the Iskhoots, are another example of genetic engineering. The outer body, the Isk, was created by the Yoort, who also modify themselves to be symbotic to the Isk. Also, a being known as the Ellimist has made species such as the Pemalites by this method.

In the 1983 film Anna to the Infinite Power, the main character was one of seven genetically cloned humans created by Anna Zimmerman as a way to groom a perfect person in her image. After her death, her work was carried on by her successor Dr. Henry Jelliff, who had other plans for the project. But in the end we learn that her original genetic creation, Michaela Dupont, has already acquired her creator’s abilities, including how to build a genetic replicator from scratch.

The 1996 video game series Resident Evil involves the creation of genetically engineered viruses which turn humans and animals into organisms such as zombies, the Tyrants or Hunters by a worldwide pharmaceutical company called the Umbrella Corporation.

In the video game series BioShock, most of the enemies in both BioShock and BioShock 2, referred to as “splicers”, as well as the player, gain superpowers and enhance their physical and mental capabilities by means of genetically engineered plasmids, created by use of ADAM stem cells secreted by a species of sea slug.[9]

The novel Beggars in Spain by Nancy Kress and its sequels are widely recognized by science fiction critics as among the most sophisticated fictional treatments of genetic engineering. They portray genetically-engineered characters whose abilities are far greater than those of ordinary humans (e.g. they are effectively immortal and they function without needing to sleep). At issue is what responsibility they have to use their abilities to help “normal” human beings. Kress explores libertarian and more collectivist philosophies, attempting to define the extent of people’s mutual responsibility for each other’s welfare.

In the Battletech science fiction series, the Clans have developed a genetic engineering program for their warriors, consisting of eugenics and the use of artificial wombs.

In The Champion Maker, a novel by Kevin Joseph, a track coach and a teenage phenom stumble upon a dark conspiracy involving genetic engineering while pursuing Olympic gold.

In the CoDominium series, the planet Sauron develops a supersoldier program. The result were the Sauron Cyborgs, and soldiers. The Cyborgs, who made up only a very small part of the population of Sauron, were part highly genetically engineered human, and part machine. Cyborgs held very high status in Sauron society.

Sauron soldiers, who made up the balance of the population, were the result of generations of genetic engineering. The Sauron soldiers had a variety of physical characteristics and abilities that made the soldiers the best in combat and survival in many hostile environments. For instance, their bones were stronger than unmodified humans. Their lungs extract oxygen more efficiently than normal unmodified humans, allowing them to exert themselves without getting short of breath, or function at high altitudes. Sauron soldiers also have the ability to change the focal length of their eyes, so that they can “zoom” in on a distant object, much like an eagle.

The alien Moties also have used genetic engineering.

In the science fiction series Crest of the Stars, the Abh are a race of genetically engineered humans, who continue to practice the technology. All Abh have been adapted to live in zero-gravity environments, with the same features such as beauty, long life, lifelong youthful appearance, blue hair, and a “space sensory organ”.

In the 2000 TV series Dark Angel, the main character Max is one of a group of genetically engineered supersoldiers spliced with feline DNA.

In military science fiction 1993 television series Exosquad, the plot revolves around the conflict between Terrans (baseline humans) and Neosapiens, a race of genetically engineered sentient (and sterile) humanoids, who were originally bred for slave labour but revolted under the leadership of Phaeton and captured the Homeworlds (Earth, Venus and Mars). During the war, various sub-broods of Neosapiens were invented, such as, Neo Megas (intellectually superior to almost any being in the Solar System), Neo Warriors (cross-breeds with various animals) and Neo Lords (the ultimate supersoldiers).

Genetic modification is also found in the 2002 anime series Gundam SEED. It features enhanced humans called Coordinators who were created from ordinary humans through genetic modification.

In Marvel Comics, the 31st century adventurers called the Guardians of the Galaxy are genetically engineered residents of Mercury, Jupiter, and Pluto.

The 1997 film Gattaca deals with the idea of genetic engineering and eugenics as it projects what class relations would look like in a future society after a few generations of the possibility of genetic engineering.

In Marvel Comics, the Inhumans are the result of genetic engineering of early humans by the Kree alien race.

Rather than deliberate engineering, this 2017 novel by British author Steve Turnbull features a plague that carries genetic material across species, causing a wide variety of mutations. Human attempts to control this plague have resulted in a fascist dystopia.

In the Leviathan universe, a group known as the Darwinists use genetically engineered animals as weapons.

The 2000AD strip, Lobster Random features a former soldier-turned-torturer, who has been modified to not feel pain or need to sleep and has a pair of lobster claws grafted to his hips. This state has left him somewhat grouchy.

In Metal Gear Solid, the Genome Army were given gene therapy enhancements.

Also in the series, the Les Enfants Terribles project involved genetic engineering.

The Moreau series by S. Andrew Swann has as the central premise the proliferation of humanoid genetically-engineered animals. The name of the series (and of the creatures themselves) comes from the H. G. Wells novel The Island of Dr. Moreau. In the Wells novel, humanoid animals were created surgically, though this detail has been changed to be genetic manipulation in most film adaptations.

The Neanderthal Parallax novel by Robert J. Sawyer depicts a eugenic society that has benefitted immensely from the sterilization of dangerous criminals as well as preventing the 5% least intelligent from procreating for ten generations.

In the Neon Genesis Evangelion anime series, the character Rei Ayanami is implied to be a lab-created being combining human and angelic DNA. (compare to the Biblical Nephilim)

Genetic engineering (or something very like it) features prominently in Last and First Men, a 1930 novel by Olaf Stapledon.

Genetic engineering is depicted as widespread in the civilized world of Oryx and Crake. Prior to the apocalypse, though, its use among humans is not mentioned. Author Margaret Atwood describes many transgenic creatures such as Pigoons (though originally designed to be harvested for organs, post-apocalyptic-plague, they become more intelligent and vicious, traveling in packs), Snats (snake-rat hybrids who may or may not be extinct), wolvogs (wolf-dog hybrids), and the relatively harmless “rakunks” (skunk-raccoon hybrids, originally designed as pets with no scent glands).

In Plague, a 1978 film, a bacterium in an agricultural experiment accidentally escapes from a research laboratory in Canada, reaching the American Northeast and Great Britain.

Using a method similar to the DNA Resequencer from Stargate SG-1, and even called DNA Resequencing, the Operation Overdrive Power Rangers were given powers of superhuman strength, enhanced hearing, enhanced eyesight, super bouncing, super speed, and invisibility.

Quake II and Quake 4, released in 1997 and 2005, contain genetically-engineered Stroggs.

In the long-running 2006 series Rogue Trooper, the eponymous hero is a Genetic Infantryman, one of an elite group of supersoldiers genetically modified to resist the poisons left in the Nu-Earth atmosphere by decades of war. The original concept from the pages of 80s cult sci-fi comic 2000 AD (of Judge Dredd fame).

James Blish’s The Seedling Stars (1956) is the classic story of controlled mutation for adaptability. In this novel (originally a series of short stories) the Adapted Men are reshaped human beings, designed for life on a variety of other planets. This is one of science fiction’s most unreservedly optimistic accounts to date of technological efforts to reshape human beings.

In “The Man Who Grew Too Much” episode (2014), Sideshow Bob steals DNA from a GMO company, thus making himself the very first genetically engineered human, and attempts to combine his DNA with that of the smartest people ever to exist on Earth.

In Sleeper, a 1973 parody of many science fiction tropes, genetically modified crops are shown to grow gigantic.

The short-lived 1990s television series Space: Above and Beyond includes a race of genetically engineered and artificially gestated humans who are born at the physical age of 18, and are collectively known as InVitros or sometimes, derogatorily, “tanks” or “nipple-necks”. At the time of the series storyline, this artificial human race was integrated with the parent species, but significant discrimination still occurred.

The Ultimate Life Form project that produced Shadow the Hedgehog and Biolizard in the Sonic the Hedgehog series was a genetic engineering project.

In the Star Trek universe, genetic engineering has featured in a couple of films, and a number of television episodes.

The Breen, the Dominion, Species 8472, the Xindi, and the Federation use technology with organic components.

Khan Noonien Singh, who appeared in Space Seed and Star Trek II: The Wrath of Khan, was a product of genetic engineering. His physical structure was modified to make him stronger and to give him greater stamina than a regular human. His mind was also enhanced. However, the creation of Khan would have serious consequences because the superior abilities given to him created superior ambition. Along with other enhanced individuals, they tried to take over the planet. When they were reawakened by the Enterprise, Khan set himself to taking over the universe. Later, he became consumed by grief and rage, and set himself on the goal of destroying Kirk.

Others of these genetically enhanced augments wreaked havoc in the 22nd century, and eventually some of their enhanced DNA was blended with Klingon DNA, creating the human-looking Klingons of the early 23rd century (See Star Trek: Enterprise episodes “Affliction” and “Divergence”).

Because of the experiences with genetic engineering, the Federation had banned it except to correct genetic birth defects, but a number of parents still illegally subjected their children to genetic engineering for a variety of reasons. This often created brilliant but unstable individuals. Such children are not allowed to serve in Starfleet or practice medicine, though Julian Bashir is a notable exception to this. Despite the ban, the Federation allowed the Darwin station to conduct human genetic engineering, which resulted in a telepathic, telekentic humans with a very effective immune system.

In Attack of the Clones, the Kamino cloners who created the clone army for the Galactic Republic had used engineering to enhance their clones. They modified the genetic structure of all but one to accelerate their growth rate, make them less independent, and make them better suited to combat operations.

Later, the Yuuzhan Vong are a race who exclusively use organic technology and regard mechanical technology as heresy. Everything from starships to communications devices to weapons are bred and grown to suit their needs.

In the show Stargate SG-1, the DNA Resequencer was a device built by the Ancients, designed to make extreme upgrades to humans by realigning their DNA and upgrading their brain activity. The machine gave them superhuman abilities, such as telekensis, telepathy, precognition, superhuman senses, strength, and intellect, the power to heal at an incredible rate, and the power to heal others by touch.

In the futuristic tabletop and video game series, Warhammer 40,000, the Imperium of Man uses genetic engineering to enhance the abilities of various militant factions such as the Space Marines, the Grey Knights, and the Adeptus Custodes. A sample or a synthesized version of the gene seed, a “part” of the original Primarch’s or leaders DNA is used in the transformation of these superhuman warriors.

At the same time, the Tau Empire uses a form of eugenic breeding to improve the physical and mental condition of its various castes.

In the e-book, Methuselah’s Virus, an ageing pharmaceutical billionaire accidentally creates a contagious virus capable of infecting people with extreme longevity when his genetic engineering experiment goes wrong. The novel then examines the problem of what happens if Methuselah’s Virus is at risk of spreading to everyone on the entire planet.

In World Hunger, author Brian Kenneth Swain paints the harrowing picture of a life sciences company that field tests a new strain of genetically modified crop, the unexpected side effect of which is the creation of several new species of large and very aggressive insects.

Genetic engineering is an essential theme of the illustrated book Man After Man: An Anthropology of the Future by Dougal Dixon, where it is used to colonize other star systems and save the humans of Earth from extinction.

The Survival Gene e-book contains the author Artsun Akopyan’s idea that people can’t preserve nature as it is forever, so they’ll have to change their own genetics in the future or die. In the novel, wave genetics is used to save humankind and all life on Earth.

A series of books by David Brin in which humans have encountered the Five Galazies, a multitude of sentient species which all practice Uplift raising species to sapience through genetic engineering. Humans, believing they have risen to sapience through evolution alone, are seen as heretics. But they have some status because at the time of contact humans had already Uplifted two species chimpanzees and bottlenose dolphins.

Eugenics is a recurrent theme in science fiction, often with both dystopian and utopian elements. The two giant contributions in this field are the novel Brave New World (1932) by Aldous Huxley, which describes a society where control of human biology by the state results in permanent social stratification.

There tends to be a eugenic undercurrent in the science fiction concept of the supersoldier. Several depictions of these supersoldiers usually have them bred for combat or genetically selected for attributes that are beneficial to modern or future combat.

The Brave New World theme also plays a role in the 1997 film Gattaca, whose plot turns around reprogenetics, genetic testing, and the social consequences of eugenics. Boris Vian (under the pseudonym Vernon Sullivan) takes a more light-hearted approach in his novel Et on tuera tous les affreux (“And we’ll kill all the ugly ones”).

Other novels touching upon the subject include The Gate to Women’s Country by Sheri S. Tepper and That Hideous Strength by C. S. Lewis. The Eugenics Wars are a significant part of the background story of the Star Trek universe (episodes “Space Seed”, “Borderland”, “Cold Station 12”, “The Augments” and the film Star Trek II: The Wrath of Khan). Eugenics also plays a significant role in the Neanderthal Parallax trilogy where eugenics-practicing Neanderthals from a near-utopian parallel world create a gateway to earth. Cowl by Neal Asher describes the collapse of western civilization due to dysgenics. Also Eugenics is the name for the medical company in La Foire aux immortels book by Enki Bilal and on the Immortel (Ad Vitam) movie by the same author.

In Frank Herbert’s Dune series of novels, selective breeding programs form a significant theme. Early in the series, the Bene Gesserit religious order manipulates breeding patterns over many generations in order to create the Kwisatz Haderach. In God Emperor of Dune, the emperor Leto II again manipulates human breeding in order to achieve his own ends. The Bene Tleilaxu also employed genetic engineering to create human beings with specific genetic attributes. The Dune series ended with causal determinism playing a large role in the development of behavior, but the eugenics theme remained a crucial part of the story.

In Orson Scott Card’s novel Ender’s Game, Ender is only allowed to be conceived because of a special government exception due to his parent’s high intelligence and the extraordinary performance of his siblings. In Ender’s Shadow, Bean is a test-tube baby and the result of a failed eugenics experiment aimed at creating child geniuses.

In the novels Methuselah’s Children and Time Enough for Love by Robert A. Heinlein, a large trust fund is created to give financial encouragement to marriage among people (the Howard Families) whose parents and grandparents were long lived. The result is a subset of Earth’s population who has significantly above-average life spans. Members of this group appear in many of the works by the same author.

In the 1982 Robert Heinlein novel Friday, the main character has been genetically engineered from multiple sets of donors, including, as she finds out later her boss. These enhancements give her superior strength, speed, eyesight in addition to healing and other advanced attributes. Creations like her are considered to be AP’s (Artificial Person).

In Eoin Colfer’s book The Supernaturalist, Ditto is a Bartoli Baby, which is the name for a failed experiment of the famed Dr. Bartoli. Bartoli tried to create a superior race of humans, but they ended in arrested development, with mutations including extrasensory perception and healing hands.

In Larry Niven’s Ringworld series, the character Teela Brown is a result of several generations of winners of the “Birthright Lottery”, a system which attempts to encourage lucky people to breed, treating good luck as a genetic trait.

In season 2 of Dark Angel, the main ‘bad guy’ Ames White is a member of a cult known as the Conclave which has infiltrated various levels of society to breed super-humans. They are trying to exterminate all the Transgenics, including the main character Max Guevara, whom they view as being genetically unclean for having some animal DNA spliced with human.

In the movie Immortel (Ad Vitam), Director/Writer Enki Bilal titled the name of the evil corrupt organization specializing in genetic manipulation, and some very disturbing genetic “enhancement” eugenics. Eugenics has come to be a powerful organization and uses people and mutants of “lesser” genetic stock as guinea pigs. The movie is based on the Nikopol trilogy in Heavy Metal comic books.

In the video game Grand Theft Auto: Vice City, a fictional character called Pastor Richards, a caricature of an extreme and insane televangelist, is featured as a guest on a discussion radio show about morality. On this show, he describes shooting people who do not agree with him and who are not “morally correct”, which the show’s host describes as “amateur eugenics”.

In the 2006 Mike Judge film Idiocracy, a fictional character, pvt. Joe Bauers, aka Not Sure (played by Luke Wilson), awakens from a cryogenic stasis in the year 2505 into a world devastated by dysgenic degeneration. Bauers, who was chosen for his averageness, is discovered to be the smartest human alive and eventually becomes president of the United States.

The manga series Battle Angel Alita and its sequel Battle Angel Alita: Last Order (Gunnm and Gunnm: Last Order as it is known in Japan) by Yukito Kishiro, contains multiple references to the theme of eugenics. The most obvious is the sky city Tiphares (Salem in Japanese edition). Dr. Desty Nova, in the first series in Volume 9, reveals the eugenical nature of the city to Alita (Gally or Yoko) and it is further explored in the sequel series. A James Cameron movie based on the series is due for release on 2018.[10]

In the French 2000 police drama Crimson Rivers, inspectors Pierre Niemans (played by Jean Reno) and his colleague Max Kerkerian (Vincent Cassel) attempt to solve series of murders triggered by eugenics experiment that was going on for years in university town of Guernon.

In the Cosmic Era universe of the Gundam anime series (Mobile Suit Gundam SEED), war is fought between the normal human beings without genetic enhancements, also known as the Naturals, and the Coordinators, who are genetically enhanced. It explores the pros and cons as well as possible repercussions from Eugenics

The Khommites of planet Khomm practice this through the method of self-cloning, believing they are perfect.

The book Uglies, part of a four-book series by Scott Westerfeld, revolves around a girl named Tally who lives in a world where everyone at the age of sixteen receives extensive cosmetic surgery to turn into “Pretties” and join society. Although it deals with extreme cosmetic surgery, the utopian (or dystopian, depending on one’s interpretation) ideals in the book are similar to those present in the books mentioned above.

The rest is here:

Genetic engineering in science fiction – Wikipedia

Genetic Engineering in Agriculture | Union of Concerned …

While the risks of genetic engineering are often exaggerated or misrepresented, GE crops do have the potential to cause a variety of health problems and environmental impacts. For instance, they may spread undesirable traits to weeds and non-GE crops, produce new allergens and toxins, or harm animals that consume them.

At least one major environmental impact of genetic engineering has already reached critical proportions: overuse of herbicide-tolerant GE crops has spurred an increase in herbicide use and an epidemic of herbicide-resistant “superweeds,” which will lead to even more herbicide use.

How likely are other harmful GE impacts to occur? This is a difficult question to answer. Each crop-gene combination poses its own set of risks. While risk assessments are conducted as part of GE product approval, the data are generally supplied by the company seeking approval, and GE companies use their patent rights to exercise tight control over research on their products.

In short, there is a lot we don’t know about the long-term and epidemiological risks of GEwhich is no reason for panic, but a good reason for caution, particularly in view of alternatives that are more effective and economical.

Excerpt from:

Genetic Engineering in Agriculture | Union of Concerned …

Genetic engineering in science fiction – Wikipedia

In literature and especially in science fiction, genetic engineering has been used as a theme or a plot device in many stories.[1][2]

In his 1924 essay Daedalus, or Science and the Future, J. B. S. Haldane predicted a day when biologists would invent new algae to feed the world and ectogenetic children would be created and modified using eugenic selection. Aldous Huxley developed these ideas in a satirical direction for his 1932 novel Brave New World, in which ectogenetic embryos were developed in selected environments to create children of an ‘Alpha’, ‘Beta’, or ‘Gamma’ type.[3]

The advent of large-scale genetic engineering has increased its presence in fiction.[4][5] Genetics research consortia, such as the Wellcome Trust Sanger Institute, have felt the need to distinguish genetic engineering fact from fiction in explaining their work to the public,[1] and have explored the role that genetic engineering has played in the public perception of programs, such as the Human Genome Project.[6]

Beyond the usual library catalog classifications,[7] the Wellcome Trust Sanger Institute[1] and the NHGRI[6] have compiled catalogs of literature in various media with genetics and genetic engineering as a theme or plot device. Such compilations are also available at fan sites.[8]

In the 2000 television series Andromeda, the Nietzscheans (Homo sapiens invictus in Latin) are a race of genetically engineered humans who religiously follow the works of Friedrich Nietzsche, social Darwinism and Dawkinite genetic competitiveness. They claim to be physically perfect and are distinguished by bone blades protruding outwards from the wrist area.

In the book 2312 by Kim Stanley Robinson, genetic engineering of humans, plants and animals and how that affects a society spread over the solar system is explored.

In the Animorphs book series, race of aliens known as the Hork-Bajir were engineered by a race known as the Arns. Another race, the Iskhoots, are another example of genetic engineering. The outer body, the Isk, was created by the Yoort, who also modify themselves to be symbotic to the Isk. Also, a being known as the Ellimist has made species such as the Pemalites by this method.

In the 1983 film Anna to the Infinite Power, the main character was one of seven genetically cloned humans created by Anna Zimmerman as a way to groom a perfect person in her image. After her death, her work was carried on by her successor Dr. Henry Jelliff, who had other plans for the project. But in the end we learn that her original genetic creation, Michaela Dupont, has already acquired her creator’s abilities, including how to build a genetic replicator from scratch.

The 1996 video game series Resident Evil involves the creation of genetically engineered viruses which turn humans and animals into organisms such as zombies, the Tyrants or Hunters by a worldwide pharmaceutical company called the Umbrella Corporation.

In the video game series BioShock, most of the enemies in both BioShock and BioShock 2, referred to as “splicers”, as well as the player, gain superpowers and enhance their physical and mental capabilities by means of genetically engineered plasmids, created by use of ADAM stem cells secreted by a species of sea slug.[9]

The novel Beggars in Spain by Nancy Kress and its sequels are widely recognized by science fiction critics as among the most sophisticated fictional treatments of genetic engineering. They portray genetically-engineered characters whose abilities are far greater than those of ordinary humans (e.g. they are effectively immortal and they function without needing to sleep). At issue is what responsibility they have to use their abilities to help “normal” human beings. Kress explores libertarian and more collectivist philosophies, attempting to define the extent of people’s mutual responsibility for each other’s welfare.

In the Battletech science fiction series, the Clans have developed a genetic engineering program for their warriors, consisting of eugenics and the use of artificial wombs.

In The Champion Maker, a novel by Kevin Joseph, a track coach and a teenage phenom stumble upon a dark conspiracy involving genetic engineering while pursuing Olympic gold.

In the CoDominium series, the planet Sauron develops a supersoldier program. The result were the Sauron Cyborgs, and soldiers. The Cyborgs, who made up only a very small part of the population of Sauron, were part highly genetically engineered human, and part machine. Cyborgs held very high status in Sauron society.

Sauron soldiers, who made up the balance of the population, were the result of generations of genetic engineering. The Sauron soldiers had a variety of physical characteristics and abilities that made the soldiers the best in combat and survival in many hostile environments. For instance, their bones were stronger than unmodified humans. Their lungs extract oxygen more efficiently than normal unmodified humans, allowing them to exert themselves without getting short of breath, or function at high altitudes. Sauron soldiers also have the ability to change the focal length of their eyes, so that they can “zoom” in on a distant object, much like an eagle.

The alien Moties also have used genetic engineering.

In the science fiction series Crest of the Stars, the Abh are a race of genetically engineered humans, who continue to practice the technology. All Abh have been adapted to live in zero-gravity environments, with the same features such as beauty, long life, lifelong youthful appearance, blue hair, and a “space sensory organ”.

In the 2000 TV series Dark Angel, the main character Max is one of a group of genetically engineered supersoldiers spliced with feline DNA.

In military science fiction 1993 television series Exosquad, the plot revolves around the conflict between Terrans (baseline humans) and Neosapiens, a race of genetically engineered sentient (and sterile) humanoids, who were originally bred for slave labour but revolted under the leadership of Phaeton and captured the Homeworlds (Earth, Venus and Mars). During the war, various sub-broods of Neosapiens were invented, such as, Neo Megas (intellectually superior to almost any being in the Solar System), Neo Warriors (cross-breeds with various animals) and Neo Lords (the ultimate supersoldiers).

Genetic modification is also found in the 2002 anime series Gundam SEED. It features enhanced humans called Coordinators who were created from ordinary humans through genetic modification.

In Marvel Comics, the 31st century adventurers called the Guardians of the Galaxy are genetically engineered residents of Mercury, Jupiter, and Pluto.

The 1997 film Gattaca deals with the idea of genetic engineering and eugenics as it projects what class relations would look like in a future society after a few generations of the possibility of genetic engineering.

In Marvel Comics, the Inhumans are the result of genetic engineering of early humans by the Kree alien race.

Rather than deliberate engineering, this 2017 novel by British author Steve Turnbull features a plague that carries genetic material across species, causing a wide variety of mutations. Human attempts to control this plague have resulted in a fascist dystopia.

In the Leviathan universe, a group known as the Darwinists use genetically engineered animals as weapons.

The 2000AD strip, Lobster Random features a former soldier-turned-torturer, who has been modified to not feel pain or need to sleep and has a pair of lobster claws grafted to his hips. This state has left him somewhat grouchy.

In Metal Gear Solid, the Genome Army were given gene therapy enhancements.

Also in the series, the Les Enfants Terribles project involved genetic engineering.

The Moreau series by S. Andrew Swann has as the central premise the proliferation of humanoid genetically-engineered animals. The name of the series (and of the creatures themselves) comes from the H. G. Wells novel The Island of Dr. Moreau. In the Wells novel, humanoid animals were created surgically, though this detail has been changed to be genetic manipulation in most film adaptations.

The Neanderthal Parallax novel by Robert J. Sawyer depicts a eugenic society that has benefitted immensely from the sterilization of dangerous criminals as well as preventing the 5% least intelligent from procreating for ten generations.

In the Neon Genesis Evangelion anime series, the character Rei Ayanami is implied to be a lab-created being combining human and angelic DNA. (compare to the Biblical Nephilim)

Genetic engineering (or something very like it) features prominently in Last and First Men, a 1930 novel by Olaf Stapledon.

Genetic engineering is depicted as widespread in the civilized world of Oryx and Crake. Prior to the apocalypse, though, its use among humans is not mentioned. Author Margaret Atwood describes many transgenic creatures such as Pigoons (though originally designed to be harvested for organs, post-apocalyptic-plague, they become more intelligent and vicious, traveling in packs), Snats (snake-rat hybrids who may or may not be extinct), wolvogs (wolf-dog hybrids), and the relatively harmless “rakunks” (skunk-raccoon hybrids, originally designed as pets with no scent glands).

In Plague, a 1978 film, a bacterium in an agricultural experiment accidentally escapes from a research laboratory in Canada, reaching the American Northeast and Great Britain.

Using a method similar to the DNA Resequencer from Stargate SG-1, and even called DNA Resequencing, the Operation Overdrive Power Rangers were given powers of superhuman strength, enhanced hearing, enhanced eyesight, super bouncing, super speed, and invisibility.

Quake II and Quake 4, released in 1997 and 2005, contain genetically-engineered Stroggs.

In the long-running 2006 series Rogue Trooper, the eponymous hero is a Genetic Infantryman, one of an elite group of supersoldiers genetically modified to resist the poisons left in the Nu-Earth atmosphere by decades of war. The original concept from the pages of 80s cult sci-fi comic 2000 AD (of Judge Dredd fame).

James Blish’s The Seedling Stars (1956) is the classic story of controlled mutation for adaptability. In this novel (originally a series of short stories) the Adapted Men are reshaped human beings, designed for life on a variety of other planets. This is one of science fiction’s most unreservedly optimistic accounts to date of technological efforts to reshape human beings.

In “The Man Who Grew Too Much” episode (2014), Sideshow Bob steals DNA from a GMO company, thus making himself the very first genetically engineered human, and attempts to combine his DNA with that of the smartest people ever to exist on Earth.

In Sleeper, a 1973 parody of many science fiction tropes, genetically modified crops are shown to grow gigantic.

The short-lived 1990s television series Space: Above and Beyond includes a race of genetically engineered and artificially gestated humans who are born at the physical age of 18, and are collectively known as InVitros or sometimes, derogatorily, “tanks” or “nipple-necks”. At the time of the series storyline, this artificial human race was integrated with the parent species, but significant discrimination still occurred.

The Ultimate Life Form project that produced Shadow the Hedgehog and Biolizard in the Sonic the Hedgehog series was a genetic engineering project.

In the Star Trek universe, genetic engineering has featured in a couple of films, and a number of television episodes.

The Breen, the Dominion, Species 8472, the Xindi, and the Federation use technology with organic components.

Khan Noonien Singh, who appeared in Space Seed and Star Trek II: The Wrath of Khan, was a product of genetic engineering. His physical structure was modified to make him stronger and to give him greater stamina than a regular human. His mind was also enhanced. However, the creation of Khan would have serious consequences because the superior abilities given to him created superior ambition. Along with other enhanced individuals, they tried to take over the planet. When they were reawakened by the Enterprise, Khan set himself to taking over the universe. Later, he became consumed by grief and rage, and set himself on the goal of destroying Kirk.

Others of these genetically enhanced augments wreaked havoc in the 22nd century, and eventually some of their enhanced DNA was blended with Klingon DNA, creating the human-looking Klingons of the early 23rd century (See Star Trek: Enterprise episodes “Affliction” and “Divergence”).

Because of the experiences with genetic engineering, the Federation had banned it except to correct genetic birth defects, but a number of parents still illegally subjected their children to genetic engineering for a variety of reasons. This often created brilliant but unstable individuals. Such children are not allowed to serve in Starfleet or practice medicine, though Julian Bashir is a notable exception to this. Despite the ban, the Federation allowed the Darwin station to conduct human genetic engineering, which resulted in a telepathic, telekentic humans with a very effective immune system.

In Attack of the Clones, the Kamino cloners who created the clone army for the Galactic Republic had used engineering to enhance their clones. They modified the genetic structure of all but one to accelerate their growth rate, make them less independent, and make them better suited to combat operations.

Later, the Yuuzhan Vong are a race who exclusively use organic technology and regard mechanical technology as heresy. Everything from starships to communications devices to weapons are bred and grown to suit their needs.

In the show Stargate SG-1, the DNA Resequencer was a device built by the Ancients, designed to make extreme upgrades to humans by realigning their DNA and upgrading their brain activity. The machine gave them superhuman abilities, such as telekensis, telepathy, precognition, superhuman senses, strength, and intellect, the power to heal at an incredible rate, and the power to heal others by touch.

In the futuristic tabletop and video game series, Warhammer 40,000, the Imperium of Man uses genetic engineering to enhance the abilities of various militant factions such as the Space Marines, the Grey Knights, and the Adeptus Custodes. A sample or a synthesized version of the gene seed, a “part” of the original Primarch’s or leaders DNA is used in the transformation of these superhuman warriors.

At the same time, the Tau Empire uses a form of eugenic breeding to improve the physical and mental condition of its various castes.

In the e-book, Methuselah’s Virus, an ageing pharmaceutical billionaire accidentally creates a contagious virus capable of infecting people with extreme longevity when his genetic engineering experiment goes wrong. The novel then examines the problem of what happens if Methuselah’s Virus is at risk of spreading to everyone on the entire planet.

In World Hunger, author Brian Kenneth Swain paints the harrowing picture of a life sciences company that field tests a new strain of genetically modified crop, the unexpected side effect of which is the creation of several new species of large and very aggressive insects.

Genetic engineering is an essential theme of the illustrated book Man After Man: An Anthropology of the Future by Dougal Dixon, where it is used to colonize other star systems and save the humans of Earth from extinction.

The Survival Gene e-book contains the author Artsun Akopyan’s idea that people can’t preserve nature as it is forever, so they’ll have to change their own genetics in the future or die. In the novel, wave genetics is used to save humankind and all life on Earth.

A series of books by David Brin in which humans have encountered the Five Galazies, a multitude of sentient species which all practice Uplift raising species to sapience through genetic engineering. Humans, believing they have risen to sapience through evolution alone, are seen as heretics. But they have some status because at the time of contact humans had already Uplifted two species chimpanzees and bottlenose dolphins.

Eugenics is a recurrent theme in science fiction, often with both dystopian and utopian elements. The two giant contributions in this field are the novel Brave New World (1932) by Aldous Huxley, which describes a society where control of human biology by the state results in permanent social stratification.

There tends to be a eugenic undercurrent in the science fiction concept of the supersoldier. Several depictions of these supersoldiers usually have them bred for combat or genetically selected for attributes that are beneficial to modern or future combat.

The Brave New World theme also plays a role in the 1997 film Gattaca, whose plot turns around reprogenetics, genetic testing, and the social consequences of eugenics. Boris Vian (under the pseudonym Vernon Sullivan) takes a more light-hearted approach in his novel Et on tuera tous les affreux (“And we’ll kill all the ugly ones”).

Other novels touching upon the subject include The Gate to Women’s Country by Sheri S. Tepper and That Hideous Strength by C. S. Lewis. The Eugenics Wars are a significant part of the background story of the Star Trek universe (episodes “Space Seed”, “Borderland”, “Cold Station 12”, “The Augments” and the film Star Trek II: The Wrath of Khan). Eugenics also plays a significant role in the Neanderthal Parallax trilogy where eugenics-practicing Neanderthals from a near-utopian parallel world create a gateway to earth. Cowl by Neal Asher describes the collapse of western civilization due to dysgenics. Also Eugenics is the name for the medical company in La Foire aux immortels book by Enki Bilal and on the Immortel (Ad Vitam) movie by the same author.

In Frank Herbert’s Dune series of novels, selective breeding programs form a significant theme. Early in the series, the Bene Gesserit religious order manipulates breeding patterns over many generations in order to create the Kwisatz Haderach. In God Emperor of Dune, the emperor Leto II again manipulates human breeding in order to achieve his own ends. The Bene Tleilaxu also employed genetic engineering to create human beings with specific genetic attributes. The Dune series ended with causal determinism playing a large role in the development of behavior, but the eugenics theme remained a crucial part of the story.

In Orson Scott Card’s novel Ender’s Game, Ender is only allowed to be conceived because of a special government exception due to his parent’s high intelligence and the extraordinary performance of his siblings. In Ender’s Shadow, Bean is a test-tube baby and the result of a failed eugenics experiment aimed at creating child geniuses.

In the novels Methuselah’s Children and Time Enough for Love by Robert A. Heinlein, a large trust fund is created to give financial encouragement to marriage among people (the Howard Families) whose parents and grandparents were long lived. The result is a subset of Earth’s population who has significantly above-average life spans. Members of this group appear in many of the works by the same author.

In the 1982 Robert Heinlein novel Friday, the main character has been genetically engineered from multiple sets of donors, including, as she finds out later her boss. These enhancements give her superior strength, speed, eyesight in addition to healing and other advanced attributes. Creations like her are considered to be AP’s (Artificial Person).

In Eoin Colfer’s book The Supernaturalist, Ditto is a Bartoli Baby, which is the name for a failed experiment of the famed Dr. Bartoli. Bartoli tried to create a superior race of humans, but they ended in arrested development, with mutations including extrasensory perception and healing hands.

In Larry Niven’s Ringworld series, the character Teela Brown is a result of several generations of winners of the “Birthright Lottery”, a system which attempts to encourage lucky people to breed, treating good luck as a genetic trait.

In season 2 of Dark Angel, the main ‘bad guy’ Ames White is a member of a cult known as the Conclave which has infiltrated various levels of society to breed super-humans. They are trying to exterminate all the Transgenics, including the main character Max Guevara, whom they view as being genetically unclean for having some animal DNA spliced with human.

In the movie Immortel (Ad Vitam), Director/Writer Enki Bilal titled the name of the evil corrupt organization specializing in genetic manipulation, and some very disturbing genetic “enhancement” eugenics. Eugenics has come to be a powerful organization and uses people and mutants of “lesser” genetic stock as guinea pigs. The movie is based on the Nikopol trilogy in Heavy Metal comic books.

In the video game Grand Theft Auto: Vice City, a fictional character called Pastor Richards, a caricature of an extreme and insane televangelist, is featured as a guest on a discussion radio show about morality. On this show, he describes shooting people who do not agree with him and who are not “morally correct”, which the show’s host describes as “amateur eugenics”.

In the 2006 Mike Judge film Idiocracy, a fictional character, pvt. Joe Bauers, aka Not Sure (played by Luke Wilson), awakens from a cryogenic stasis in the year 2505 into a world devastated by dysgenic degeneration. Bauers, who was chosen for his averageness, is discovered to be the smartest human alive and eventually becomes president of the United States.

The manga series Battle Angel Alita and its sequel Battle Angel Alita: Last Order (Gunnm and Gunnm: Last Order as it is known in Japan) by Yukito Kishiro, contains multiple references to the theme of eugenics. The most obvious is the sky city Tiphares (Salem in Japanese edition). Dr. Desty Nova, in the first series in Volume 9, reveals the eugenical nature of the city to Alita (Gally or Yoko) and it is further explored in the sequel series. A James Cameron movie based on the series is due for release on 2018.[10]

In the French 2000 police drama Crimson Rivers, inspectors Pierre Niemans (played by Jean Reno) and his colleague Max Kerkerian (Vincent Cassel) attempt to solve series of murders triggered by eugenics experiment that was going on for years in university town of Guernon.

In the Cosmic Era universe of the Gundam anime series (Mobile Suit Gundam SEED), war is fought between the normal human beings without genetic enhancements, also known as the Naturals, and the Coordinators, who are genetically enhanced. It explores the pros and cons as well as possible repercussions from Eugenics

The Khommites of planet Khomm practice this through the method of self-cloning, believing they are perfect.

The book Uglies, part of a four-book series by Scott Westerfeld, revolves around a girl named Tally who lives in a world where everyone at the age of sixteen receives extensive cosmetic surgery to turn into “Pretties” and join society. Although it deals with extreme cosmetic surgery, the utopian (or dystopian, depending on one’s interpretation) ideals in the book are similar to those present in the books mentioned above.

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Genetic engineering in science fiction – Wikipedia

Genetic Engineering in Agriculture | Union of Concerned …

While the risks of genetic engineering are often exaggerated or misrepresented, GE crops do have the potential to cause a variety of health problems and environmental impacts. For instance, they may spread undesirable traits to weeds and non-GE crops, produce new allergens and toxins, or harm animals that consume them.

At least one major environmental impact of genetic engineering has already reached critical proportions: overuse of herbicide-tolerant GE crops has spurred an increase in herbicide use and an epidemic of herbicide-resistant “superweeds,” which will lead to even more herbicide use.

How likely are other harmful GE impacts to occur? This is a difficult question to answer. Each crop-gene combination poses its own set of risks. While risk assessments are conducted as part of GE product approval, the data are generally supplied by the company seeking approval, and GE companies use their patent rights to exercise tight control over research on their products.

In short, there is a lot we don’t know about the long-term and epidemiological risks of GEwhich is no reason for panic, but a good reason for caution, particularly in view of alternatives that are more effective and economical.

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Genetic Engineering in Agriculture | Union of Concerned …

Genetic engineering – Wikipedia

Genetic engineering, also called genetic modification, is the direct manipulation of an organism’s genes using biotechnology. It is a set of technologies used to change the genetic makeup of cells, including the transfer of genes within and across species boundaries to produce improved or novel organisms. New DNA is obtained by either isolating and copying the genetic material of interest using recombinant DNA methods or by artificially synthesising the DNA. A construct is usually created and used to insert this DNA into the host organism. The first recombinant DNA molecule was made by Paul Berg in 1972 by combining DNA from the monkey virus SV40 with the lambda virus. As well as inserting genes, the process can be used to remove, or “knock out”, genes. The new DNA can be inserted randomly, or targeted to a specific part of the genome.

An organism that is generated through genetic engineering is considered to be genetically modified (GM) and the resulting entity is a genetically modified organism (GMO). The first GMO was a bacterium generated by Herbert Boyer and Stanley Cohen in 1973. Rudolf Jaenisch created the first GM animal when he inserted foreign DNA into a mouse in 1974. The first company to focus on genetic engineering, Genentech, was founded in 1976 and started the production of human proteins. Genetically engineered human insulin was produced in 1978 and insulin-producing bacteria were commercialised in 1982. Genetically modified food has been sold since 1994, with the release of the Flavr Savr tomato. The Flavr Savr was engineered to have a longer shelf life, but most current GM crops are modified to increase resistance to insects and herbicides. GloFish, the first GMO designed as a pet, was sold in the United States in December 2003. In 2016 salmon modified with a growth hormone were sold.

Genetic engineering has been applied in numerous fields including research, medicine, industrial biotechnology and agriculture. In research GMOs are used to study gene function and expression through loss of function, gain of function, tracking and expression experiments. By knocking out genes responsible for certain conditions it is possible to create animal model organisms of human diseases. As well as producing hormones, vaccines and other drugs genetic engineering has the potential to cure genetic diseases through gene therapy. The same techniques that are used to produce drugs can also have industrial applications such as producing enzymes for laundry detergent, cheeses and other products.

The rise of commercialised genetically modified crops has provided economic benefit to farmers in many different countries, but has also been the source of most of the controversy surrounding the technology. This has been present since its early use, the first field trials were destroyed by anti-GM activists. Although there is a scientific consensus that currently available food derived from GM crops poses no greater risk to human health than conventional food, GM food safety is a leading concern with critics. Gene flow, impact on non-target organisms, control of the food supply and intellectual property rights have also been raised as potential issues. These concerns have led to the development of a regulatory framework, which started in 1975. It has led to an international treaty, the Cartagena Protocol on Biosafety, that was adopted in 2000. Individual countries have developed their own regulatory systems regarding GMOs, with the most marked differences occurring between the USA and Europe.

Genetic engineering is a process that alters the genetic make-up of an organism by either removing or introducing DNA. Unlike traditionally animal and plant breeding, which involves doing multiple crosses and then selecting for the organism with the desired phenotype, genetic engineering takes the gene directly from one organism and inserts it in the other. This is much faster, can be used to insert any genes from any organism (even ones from different domains) and prevents other undesirable genes from also being added.[1]

Genetic engineering could potentially fix severe genetic disorders in humans by replacing the defective gene with a functioning one.[2] It is an important tool in research that allows the function of specific genes to be studied.[3] Drugs, vaccines and other products have been harvested from organisms engineered to produce them.[4] Crops have been developed that aid food security by increasing yield, nutritional value and tolerance to environmental stresses.[5]

The DNA can be introduced directly into the host organism or into a cell that is then fused or hybridised with the host.[6] This relies on recombinant nucleic acid techniques to form new combinations of heritable genetic material followed by the incorporation of that material either indirectly through a vector system or directly through micro-injection, macro-injection or micro-encapsulation.[7]

Genetic engineering does not normally include traditional breeding, in vitro fertilisation, induction of polyploidy, mutagenesis and cell fusion techniques that do not use recombinant nucleic acids or a genetically modified organism in the process.[6] However, some broad definitions of genetic engineering include selective breeding.[7] Cloning and stem cell research, although not considered genetic engineering,[8] are closely related and genetic engineering can be used within them.[9] Synthetic biology is an emerging discipline that takes genetic engineering a step further by introducing artificially synthesised material into an organism.[10]

Plants, animals or micro organisms that have been changed through genetic engineering are termed genetically modified organisms or GMOs.[11] If genetic material from another species is added to the host, the resulting organism is called transgenic. If genetic material from the same species or a species that can naturally breed with the host is used the resulting organism is called cisgenic.[12] If genetic engineering is used to remove genetic material from the target organism the resulting organism is termed a knockout organism.[13] In Europe genetic modification is synonymous with genetic engineering while within the United States of America and Canada genetic modification can also be used to refer to more conventional breeding methods.[14][15][16]

Humans have altered the genomes of species for thousands of years through selective breeding, or artificial selection[19]:1[20]:1 as contrasted with natural selection, and more recently through mutagenesis. Genetic engineering as the direct manipulation of DNA by humans outside breeding and mutations has only existed since the 1970s. The term “genetic engineering” was first coined by Jack Williamson in his science fiction novel Dragon’s Island, published in 1951[21] one year before DNA’s role in heredity was confirmed by Alfred Hershey and Martha Chase,[22] and two years before James Watson and Francis Crick showed that the DNA molecule has a double-helix structure though the general concept of direct genetic manipulation was explored in rudimentary form in Stanley G. Weinbaum’s 1936 science fiction story Proteus Island.[23][24]

In 1972, Paul Berg created the first recombinant DNA molecules by combining DNA from the monkey virus SV40 with that of the lambda virus.[25] In 1973 Herbert Boyer and Stanley Cohen created the first transgenic organism by inserting antibiotic resistance genes into the plasmid of an Escherichia coli bacterium.[26][27] A year later Rudolf Jaenisch created a transgenic mouse by introducing foreign DNA into its embryo, making it the worlds first transgenic animal.[28] These achievements led to concerns in the scientific community about potential risks from genetic engineering, which were first discussed in depth at the Asilomar Conference in 1975. One of the main recommendations from this meeting was that government oversight of recombinant DNA research should be established until the technology was deemed safe.[29][30]

In 1976 Genentech, the first genetic engineering company, was founded by Herbert Boyer and Robert Swanson and a year later the company produced a human protein (somatostatin) in E.coli. Genentech announced the production of genetically engineered human insulin in 1978.[31] In 1980, the U.S. Supreme Court in the Diamond v. Chakrabarty case ruled that genetically altered life could be patented.[32] The insulin produced by bacteria was approved for release by the Food and Drug Administration (FDA) in 1982.[33]

In 1983, a biotech company, Advanced Genetic Sciences (AGS) applied for U.S. government authorisation to perform field tests with the ice-minus strain of Pseudomonas syringae to protect crops from frost, but environmental groups and protestors delayed the field tests for four years with legal challenges.[34] In 1987, the ice-minus strain of P. syringae became the first genetically modified organism (GMO) to be released into the environment[35] when a strawberry field and a potato field in California were sprayed with it.[36] Both test fields were attacked by activist groups the night before the tests occurred: “The world’s first trial site attracted the world’s first field trasher”.[35]

The first field trials of genetically engineered plants occurred in France and the USA in 1986, tobacco plants were engineered to be resistant to herbicides.[37] The Peoples Republic of China was the first country to commercialise transgenic plants, introducing a virus-resistant tobacco in 1992.[38] In 1994 Calgene attained approval to commercially release the first genetically modified food, the Flavr Savr, a tomato engineered to have a longer shelf life.[39] In 1994, the European Union approved tobacco engineered to be resistant to the herbicide bromoxynil, making it the first genetically engineered crop commercialised in Europe.[40] In 1995, Bt Potato was approved safe by the Environmental Protection Agency, after having been approved by the FDA, making it the first pesticide producing crop to be approved in the USA.[41] In 2009 11 transgenic crops were grown commercially in 25 countries, the largest of which by area grown were the USA, Brazil, Argentina, India, Canada, China, Paraguay and South Africa.[42]

In 2010, scientists at the J. Craig Venter Institute created the first synthetic genome and inserted it into an empty bacterial cell. The resulting bacterium, named Mycoplasma laboratorium, could replicate and produce proteins.[43][44] Four years later this was taken a step further when bacterium was developed that replicated a plasmid containing a unique base pair, creating the first organism engineered to use an expanded genetic alphabet.[45][46] In 2012, Jennifer Doudna and Emmanuelle Charpentier collaborated to develop the CRISPR/Cas9 system,[47][48] a technique which can be used to easily and specifically alter the genome of almost any organism.[49]

Creating a GMO is a multi-step process. Genetic engineers must first choose what gene they wish to insert into the organism. This is driven by what the aim is for the resultant organism and is built on earlier research. Genetic screens can be carried out to determine potential genes and further tests then used to identify the best candidates. The development of microarrays, transcriptomes and genome sequencing has made it much easier to find suitable genes.[50] Luck also plays its part; the round-up ready gene was discovered after scientists noticed a bacterium thriving in the presence of the herbicide.[51]

The next step is to isolate the candidate gene. The cell containing the gene is opened and the DNA is purified.[52] The gene is separated by using restriction enzymes to cut the DNA into fragments[53] or polymerase chain reaction (PCR) to amplify up the gene segment.[54] These segments can then be extracted through gel electrophoresis. If the chosen gene or the donor organism’s genome has been well studied it may already be accessible from a genetic library. If the DNA sequence is known, but no copies of the gene are available, it can also be artificially synthesised.[55] Once isolated the gene is ligated into a plasmid that is then inserted into a bacterium. The plasmid is replicated when the bacteria divide, ensuring unlimited copies of the gene are available.[56]

Before the gene is inserted into the target organism it must be combined with other genetic elements. These include a promoter and terminator region, which initiate and end transcription. A selectable marker gene is added, which in most cases confers antibiotic resistance, so researchers can easily determine which cells have been successfully transformed. The gene can also be modified at this stage for better expression or effectiveness. These manipulations are carried out using recombinant DNA techniques, such as restriction digests, ligations and molecular cloning.[57]

There are a number of techniques available for inserting the gene into the host genome. Some bacteria can naturally take up foreign DNA. This ability can be induced in other bacteria via stress (e.g. thermal or electric shock), which increases the cell membrane’s permeability to DNA; up-taken DNA can either integrate with the genome or exist as extrachromosomal DNA. DNA is generally inserted into animal cells using microinjection, where it can be injected through the cell’s nuclear envelope directly into the nucleus, or through the use of viral vectors.[58]

In plants the DNA is often inserted using Agrobacterium-mediated recombination,[59] taking advantage of the Agrobacteriums T-DNA sequence that allows natural insertion of genetic material into plant cells.[60] Other methods include biolistics, where particles of gold or tungsten are coated with DNA and then shot into young plant cells,[61] and electroporation, which involves using an electric shock to make the cell membrane permeable to plasmid DNA. Due to the damage caused to the cells and DNA the transformation efficiency of biolistics and electroporation is lower than agrobacterial transformation and microinjection.[62]

As only a single cell is transformed with genetic material, the organism must be regenerated from that single cell. In plants this is accomplished through the use of tissue culture.[63][64] In animals it is necessary to ensure that the inserted DNA is present in the embryonic stem cells.[65] Bacteria consist of a single cell and reproduce clonally so regeneration is not necessary. Selectable markers are used to easily differentiate transformed from untransformed cells. These markers are usually present in the transgenic organism, although a number of strategies have been developed that can remove the selectable marker from the mature transgenic plant.[66]

Further testing using PCR, Southern hybridization, and DNA sequencing is conducted to confirm that an organism contains the new gene.[67] These tests can also confirm the chromosomal location and copy number of the inserted gene. The presence of the gene does not guarantee it will be expressed at appropriate levels in the target tissue so methods that look for and measure the gene products (RNA and protein) are also used. These include northern hybridisation, quantitative RT-PCR, Western blot, immunofluorescence, ELISA and phenotypic analysis.[68]

The new genetic material can be inserted randomly within the host genome or targeted to a specific location. The technique of gene targeting uses homologous recombination to make desired changes to a specific endogenous gene. This tends to occur at a relatively low frequency in plants and animals and generally requires the use of selectable markers. The frequency of gene targeting can be greatly enhanced through genome editing. Genome editing uses artificially engineered nucleases that create specific double-stranded breaks at desired locations in the genome, and use the cells endogenous mechanisms to repair the induced break by the natural processes of homologous recombination and nonhomologous end-joining. There are four families of engineered nucleases: meganucleases,[69][70] zinc finger nucleases,[71][72] transcription activator-like effector nucleases (TALENs),[73][74] and the Cas9-guideRNA system (adapted from CRISPR).[75][76] TALEN and CRISPR are the two most commonly used and each has its own advantages.[77] TALENs have greater target specificity, while CRISPR is easier to design and more efficient.[77] In addition to enhancing gene targeting, engineered nucleases can be used to introduce mutations at endogenous genes that generate a gene knockout.[78][79]

Genetic engineering has applications in medicine, research, industry and agriculture and can be used on a wide range of plants, animals and micro organisms. Bacteria, the first organisms to be genetically modified, can have plasmid DNA inserted containing new genes that code for medicines or enzymes that process food and other substrates.[80][81] Plants have been modified for insect protection, herbicide resistance, virus resistance, enhanced nutrition, tolerance to environmental pressures and the production of edible vaccines.[82] Most commercialised GMOs are insect resistant or herbicide tolerant crop plants.[83] Genetically modified animals have been used for research, model animals and the production of agricultural or pharmaceutical products. The genetically modified animals include animals with genes knocked out, increased susceptibility to disease, hormones for extra growth and the ability to express proteins in their milk.[84]

Genetic engineering has many applications to medicine that include the manufacturing of drugs, creation of model animals that mimic human conditions and gene therapy. One of the earliest uses of genetic engineering was to mass-produce human insulin in bacteria.[31] This application has now been applied to, human growth hormones, follicle stimulating hormones (for treating infertility), human albumin, monoclonal antibodies, antihemophilic factors, vaccines and many other drugs.[85][86] Mouse hybridomas, cells fused together to create monoclonal antibodies, have been adapted through genetic engineering to create human monoclonal antibodies.[87] In 2017, genetic engineering of chimeric antigen receptors on a patient’s own T-cells was approved by the U.S. FDA as a treatment for the cancer acute lymphoblastic leukemia. Genetically engineered viruses are being developed that can still confer immunity, but lack the infectious sequences.[88]

Genetic engineering is also used to create animal models of human diseases. Genetically modified mice are the most common genetically engineered animal model.[89] They have been used to study and model cancer (the oncomouse), obesity, heart disease, diabetes, arthritis, substance abuse, anxiety, aging and Parkinson disease.[90] Potential cures can be tested against these mouse models. Also genetically modified pigs have been bred with the aim of increasing the success of pig to human organ transplantation.[91]

Gene therapy is the genetic engineering of humans, generally by replacing defective genes with effective ones. Clinical research using somatic gene therapy has been conducted with several diseases, including X-linked SCID,[92] chronic lymphocytic leukemia (CLL),[93][94] and Parkinson’s disease.[95] In 2012, Alipogene tiparvovec became the first gene therapy treatment to be approved for clinical use.[96][97] In 2015 a virus was used to insert a healthy gene into the skin cells of a boy suffering from a rare skin disease, epidermolysis bullosa, in order to grow, and then graft healthy skin onto 80 percent of the boy’s body which was affected by the illness.[98] Germline gene therapy would result in any change being inheritable, which has raised concerns within the scientific community.[99][100] In 2015, CRISPR was used to edit the DNA of non-viable human embryos,[101][102] leading scientists of major world academies to called for a moratorium on inheritable human genome edits.[103] There are also concerns that the technology could be used not just for treatment, but for enhancement, modification or alteration of a human beings’ appearance, adaptability, intelligence, character or behavior.[104] The distinction between cure and enhancement can also be difficult to establish.[105]

Researchers are altering the genome of pigs to induce the growth of human organs to be used in transplants. Scientists are creating “gene drives”, changing the genomes of mosquitoes to make them immune to malaria, and then spreading the genetically altered mosquitoes throughout the mosquito population in the hopes of eliminating the disease.[106]

Genetic engineering is an important tool for natural scientists. Genes and other genetic information from a wide range of organisms can be inserted into bacteria for storage and modification, creating genetically modified bacteria in the process. Bacteria are cheap, easy to grow, clonal, multiply quickly, relatively easy to transform and can be stored at -80C almost indefinitely. Once a gene is isolated it can be stored inside the bacteria providing an unlimited supply for research.[107]

Organisms are genetically engineered to discover the functions of certain genes. This could be the effect on the phenotype of the organism, where the gene is expressed or what other genes it interacts with. These experiments generally involve loss of function, gain of function, tracking and expression.

Organisms can have their cells transformed with a gene coding for a useful protein, such as an enzyme, so that they will overexpress the desired protein. Mass quantities of the protein can then be manufactured by growing the transformed organism in bioreactor equipment using industrial fermentation, and then purifying the protein.[111] Some genes do not work well in bacteria, so yeast, insect cells or mammalians cells can also be used.[112] These techniques are used to produce medicines such as insulin, human growth hormone, and vaccines, supplements such as tryptophan, aid in the production of food (chymosin in cheese making) and fuels.[113] Other applications with genetically engineered bacteria could involve making them perform tasks outside their natural cycle, such as making biofuels,[114] cleaning up oil spills, carbon and other toxic waste[115] and detecting arsenic in drinking water.[116] Certain genetically modified microbes can also be used in biomining and bioremediation, due to their ability to extract heavy metals from their environment and incorporate them into compounds that are more easily recoverable.[117]

In materials science, a genetically modified virus has been used in a research laboratory as a scaffold for assembling a more environmentally friendly lithium-ion battery.[118][119] Bacteria have also been engineered to function as sensors by expressing a fluorescent protein under certain environmental conditions.[120]

One of the best-known and controversial applications of genetic engineering is the creation and use of genetically modified crops or genetically modified livestock to produce genetically modified food. Crops have been developed to increase production, increase tolerance to abiotic stresses, alter the composition of the food, or to produce novel products.[122]

The first crops to be realised commercially on a large scale provided protection from insect pests or tolerance to herbicides. Fungal and virus resistant crops have also being developed or are in development.[123][124] This make the insect and weed management of crops easier and can indirectly increase crop yield.[125][126] GM crops that directly improve yield by accelerating growth or making the plant more hardy (by improving salt, cold or drought tolerance) are also under development.[127] In 2016 Salmon have been genetically modified with growth hormones to reach normal adult size much faster.[128]

GMOs have been developed that modify the quality of produce by increasing the nutritional value or providing more industrially useful qualities or quantities.[127] The Amflora potato produces a more industrially useful blend of starches. Soybeans and canola have been genetically modified to produce more healthy oils.[129][130] The first commercialised GM food was a tomato that had delayed ripening, increasing its shelf life.[131]

Plants and animals have been engineered to produce materials they do not normally make. Pharming uses crops and animals as bioreactors to produce vaccines, drug intermediates, or the drugs themselves; the useful product is purified from the harvest and then used in the standard pharmaceutical production process.[132] Cows and goats have been engineered to express drugs and other proteins in their milk, and in 2009 the FDA approved a drug produced in goat milk.[133][134]

Genetic engineering has potential applications in conservation and natural area management. Gene transfer through viral vectors has been proposed as a means of controlling invasive species as well as vaccinating threatened fauna from disease.[135] Transgenic trees have been suggested as a way to confer resistance to pathogens in wild populations.[136] With the increasing risks of maladaptation in organisms as a result of climate change and other perturbations, facilitated adaptation through gene tweaking could be one solution to reducing extinction risks.[137] Applications of genetic engineering in conservation are thus far mostly theoretical and have yet to be put into practice.

Genetic engineering is also being used to create microbial art.[138] Some bacteria have been genetically engineered to create black and white photographs.[139] Novelty items such as lavender-colored carnations,[140] blue roses,[141] and glowing fish[142][143] have also been produced through genetic engineering.

The regulation of genetic engineering concerns the approaches taken by governments to assess and manage the risks associated with the development and release of GMOs. The development of a regulatory framework began in 1975, at Asilomar, California.[144] The Asilomar meeting recommended a set of voluntary guidelines regarding the use of recombinant technology.[145] As the technology improved USA established a committee at the Office of Science and Technology,[146] which assigned regulatory approval of GM plants to the USDA, FDA and EPA.[147] The Cartagena Protocol on Biosafety, an international treaty that governs the transfer, handling, and use of GMOs,[148] was adopted on 29 January 2000.[149] One hundred and fifty-seven countries are members of the Protocol and many use it as a reference point for their own regulations.[150]

The legal and regulatory status of GM foods varies by country, with some nations banning or restricting them, and others permitting them with widely differing degrees of regulation.[151][152][153][154] Some countries allow the import of GM food with authorisation, but either do not allow its cultivation (Russia, Norway, Israel) or have provisions for cultivation, but no GM products are yet produced (Japan, South Korea). Most countries that do not allow for GMO cultivation do permit research.[155] Some of the most marked differences occurring between the USA and Europe. The US policy focuses on the product (not the process), only looks at verifiable scientific risks and uses the concept of substantial equivalence.[156] The European Union by contrast has possibly the most stringent GMO regulations in the world.[157] All GMOs, along with irradiated food, are considered “new food” and subject to extensive, case-by-case, science-based food evaluation by the European Food Safety Authority. The criteria for authorisation fall in four broad categories: “safety,” “freedom of choice,” “labelling,” and “traceability.”[158] The level of regulation in other countries that cultivate GMOs lie in between Europe and the United States.

One of the key issues concerning regulators is whether GM products should be labeled. The European Commission says that mandatory labeling and traceability are needed to allow for informed choice, avoid potential false advertising[169] and facilitate the withdrawal of products if adverse effects on health or the environment are discovered.[170] The American Medical Association[171] and the American Association for the Advancement of Science[172] say that absent scientific evidence of harm even voluntary labeling is misleading and will falsely alarm consumers”. Labeling of GMO products in the marketplace is required in 64 countries.[173] Labeling can be mandatory up to a threshold GM content level (which varies between countries) or voluntary. In Canada and the USA labeling of GM food is voluntary,[174] while in Europe all food (including processed food) or feed which contains greater than 0.9% of approved GMOs must be labelled.[157]

Critics have objected to the use of genetic engineering on several grounds, that include ethical, ecological and economic concerns. Many of these concerns involve GM crops and whether food produced from them is safe, whether it should be labeled and what impact growing them will have on the environment. These controversies have led to litigation, international trade disputes, and protests, and to restrictive regulation of commercial products in some countries.[175]

Accusations that scientists are “playing God” and other religious issues have been ascribed to the technology from the beginning.[176] Other ethical issues raised include the patenting of life,[177] the use of intellectual property rights,[178] the level of labeling on products,[179][180] control of the food supply[181] and the objectivity of the regulatory process.[182] Although doubts have been raised,[183] economically most studies have found growing GM crops to be beneficial to farmers.[184][185][186]

Gene flow between GM crops and compatible plants, along with increased use of selective herbicides, can increase the risk of “superweeds” developing.[187] Other environmental concerns involve potential impacts on non-target organisms, including soil microbes,[188] and an increase in secondary and resistant insect pests.[189][190] Many of the environmental impacts regarding GM crops may take many years to be understood are also evident in conventional agriculture practices.[188][191] With the commercialisation of genetically modified fish there are concerns over what the environmental consequences will be if they escape.[192]

There are three main concerns over the safety of genetically modified food: whether they may provoke an allergic reaction; whether the genes could transfer from the food into human cells; and whether the genes not approved for human consumption could outcross to other crops.[193] There is a scientific consensus[194][195][196][197] that currently available food derived from GM crops poses no greater risk to human health than conventional food,[198][199][200][201][202] but that each GM food needs to be tested on a case-by-case basis before introduction.[203][204][205] Nonetheless, members of the public are much less likely than scientists to perceive GM foods as safe.[206][207][208][209]

The literature about Biodiversity and the GE food/feed consumption has sometimes resulted in animated debate regarding the suitability of the experimental designs, the choice of the statistical methods or the public accessibility of data. Such debate, even if positive and part of the natural process of review by the scientific community, has frequently been distorted by the media and often used politically and inappropriately in anti-GE crops campaigns.

Panchin, Alexander Y.; Tuzhikov, Alexander I. (14 January 2016). “Published GMO studies find no evidence of harm when corrected for multiple comparisons”. Critical Reviews in Biotechnology: 15. doi:10.3109/07388551.2015.1130684. ISSN0738-8551. PMID26767435. Here, we show that a number of articles some of which have strongly and negatively influenced the public opinion on GM crops and even provoked political actions, such as GMO embargo, share common flaws in the statistical evaluation of the data. Having accounted for these flaws, we conclude that the data presented in these articles does not provide any substantial evidence of GMO harm.

The presented articles suggesting possible harm of GMOs received high public attention. However, despite their claims, they actually weaken the evidence for the harm and lack of substantial equivalency of studied GMOs. We emphasize that with over 1783 published articles on GMOs over the last 10 years it is expected that some of them should have reported undesired differences between GMOs and conventional crops even if no such differences exist in reality. and

Yang, Y.T.; Chen, B. (2016). “Governing GMOs in the USA: science, law and public health”. Journal of the Science of Food and Agriculture. 96: 18511855. doi:10.1002/jsfa.7523. PMID26536836. It is therefore not surprising that efforts to require labeling and to ban GMOs have been a growing political issue in the USA (citing Domingo and Bordonaba, 2011).

Overall, a broad scientific consensus holds that currently marketed GM food poses no greater risk than conventional food… Major national and international science and medical associations have stated that no adverse human health effects related to GMO food have been reported or substantiated in peer-reviewed literature to date.

Despite various concerns, today, the American Association for the Advancement of Science, the World Health Organization, and many independent international science organizations agree that GMOs are just as safe as other foods. Compared with conventional breeding techniques, genetic engineering is far more precise and, in most cases, less likely to create an unexpected outcome.

GM foods currently available on the international market have passed safety assessments and are not likely to present risks for human health. In addition, no effects on human health have been shown as a result of the consumption of such foods by the general population in the countries where they have been approved. Continuous application of safety assessments based on the Codex Alimentarius principles and, where appropriate, adequate post market monitoring, should form the basis for ensuring the safety of GM foods.

“Genetically modified foods and health: a second interim statement” (PDF). British Medical Association. March 2004. Retrieved 21 March 2016. In our view, the potential for GM foods to cause harmful health effects is very small and many of the concerns expressed apply with equal vigour to conventionally derived foods. However, safety concerns cannot, as yet, be dismissed completely on the basis of information currently available.

When seeking to optimise the balance between benefits and risks, it is prudent to err on the side of caution and, above all, learn from accumulating knowledge and experience. Any new technology such as genetic modification must be examined for possible benefits and risks to human health and the environment. As with all novel foods, safety assessments in relation to GM foods must be made on a case-by-case basis.

Members of the GM jury project were briefed on various aspects of genetic modification by a diverse group of acknowledged experts in the relevant subjects. The GM jury reached the conclusion that the sale of GM foods currently available should be halted and the moratorium on commercial growth of GM crops should be continued. These conclusions were based on the precautionary principle and lack of evidence of any benefit. The Jury expressed concern over the impact of GM crops on farming, the environment, food safety and other potential health effects.

The Royal Society review (2002) concluded that the risks to human health associated with the use of specific viral DNA sequences in GM plants are negligible, and while calling for caution in the introduction of potential allergens into food crops, stressed the absence of evidence that commercially available GM foods cause clinical allergic manifestations. The BMA shares the view that that there is no robust evidence to prove that GM foods are unsafe but we endorse the call for further research and surveillance to provide convincing evidence of safety and benefit.

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Genetic engineering – Wikipedia

Genetic Engineering in Agriculture | Union of Concerned …

While the risks of genetic engineering are often exaggerated or misrepresented, GE crops do have the potential to cause a variety of health problems and environmental impacts. For instance, they may spread undesirable traits to weeds and non-GE crops, produce new allergens and toxins, or harm animals that consume them.

At least one major environmental impact of genetic engineering has already reached critical proportions: overuse of herbicide-tolerant GE crops has spurred an increase in herbicide use and an epidemic of herbicide-resistant “superweeds,” which will lead to even more herbicide use.

How likely are other harmful GE impacts to occur? This is a difficult question to answer. Each crop-gene combination poses its own set of risks. While risk assessments are conducted as part of GE product approval, the data are generally supplied by the company seeking approval, and GE companies use their patent rights to exercise tight control over research on their products.

In short, there is a lot we don’t know about the long-term and epidemiological risks of GEwhich is no reason for panic, but a good reason for caution, particularly in view of alternatives that are more effective and economical.

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Genetic Engineering in Agriculture | Union of Concerned …

Genetic Engineering: What is Genetic Engineering?

Written by Patrick Dixon

Futurist Keynote Speaker: Posts, Slides, Videos – BioTech, MedTech, Gene Therapy and Stem Cells

Video on Genetic Engineering

Genetic engineering is the alteration of genetic code by artificial means, and is therefore different from traditional selective breeding.

Huge number of other resources on this site about Genetic engineering.

Genetic engineering examples include taking the gene that programs poison in the tail of a scorpion, and combining it with a cabbage. These genetically modified cabbages kill caterpillers because they have learned to grow scorpion poison (insecticide) in their sap.

Genetic engineering also includes insertion of human genes into sheep so that they secrete alpha-1 antitrypsin in their milk – a useful substance in treating some cases of lung disease.

Genetic engineering has created a chicken with four legs and no wings.

Genetic engineering has created a goat with spider genes that creates “silk” in its milk.

Genetic engineering works because there is one language of life: human genes work in bacteria, monkey genes work in mice and earthworms. Tree genes work in bananas and frog genes work in rice. There is no limit in theory to the potential of genetic engineering.

Genetic engineering has given us the power to alter the very basis of life on earth.

Genetic engineering has been said to be no different than ancient breeding methods but this is untrue. For a start, breeding or cross-breeding, or in-breeding (for example to make pedigree dogs) all work by using the same species. In contrast genetic engineering allows us to combine fish, mouse, human and insect genes in the same person or animal.

Genetic engineering therefore has few limits – except our imagination, and our moral or ethical code.

Genetic engineering makes the whole digital revolution look nothing. Digital technology changes what we do. Genetic engineering has the power to change who we are.

Human cloning is a type of genetic engineering, but is not the same as true genetic manipulation. In human cloning, the aim is to duplicate the genes of an existing person so that an identical set is inside a human egg. The result is intended to be a cloned twin, perhaps of a dead child. Genetic engineering in its fullest form would result in the child produced having unique genes – as a result of laboratory interference, and therefore the child will not be an identikit twin.

Genetic engineering could create crops that grow in desert heat, or without fertiliser. Genetic engineering could make bananas or other fruit which contain vaccines or other medical products.

Genetic engineering is helped by the fact that it only costs $1000 to analyse someone’s genetic code (sequencing of genome) – down from $800m in 2001.

Genetic engineering is aided by techniques such as Crispr which allow scientists to swop genes between humans or between animals and humans or between animals, in a very precise and controlled way.

Genetic engineering will alter the basis of life on earth – permanently – unless controlled. This could happen if – say – mutant viruses, or bacteria, or fish or reptiles are released into the general environment.

READ FREE BOOK on Genetic Engineering – by Patrick Dixon, author of 16 books and creator of this website – read now: Chapters 1 and 2 explain basics in way which is easy to understand.

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Genetic Engineering: What is Genetic Engineering?

genetic engineering | Definition, Process, & Uses …

Genetic engineering, the artificial manipulation, modification, and recombination of DNA or other nucleic acid molecules in order to modify an organism or population of organisms.

The term genetic engineering initially referred to various techniques used for the modification or manipulation of organisms through the processes of heredity and reproduction. As such, the term embraced both artificial selection and all the interventions of biomedical techniques, among them artificial insemination, in vitro fertilization (e.g., test-tube babies), cloning, and gene manipulation. In the latter part of the 20th century, however, the term came to refer more specifically to methods of recombinant DNA technology (or gene cloning), in which DNA molecules from two or more sources are combined either within cells or in vitro and are then inserted into host organisms in which they are able to propagate.

The possibility for recombinant DNA technology emerged with the discovery of restriction enzymes in 1968 by Swiss microbiologist Werner Arber. The following year American microbiologist Hamilton O. Smith purified so-called type II restriction enzymes, which were found to be essential to genetic engineering for their ability to cleave a specific site within the DNA (as opposed to type I restriction enzymes, which cleave DNA at random sites). Drawing on Smiths work, American molecular biologist Daniel Nathans helped advance the technique of DNA recombination in 197071 and demonstrated that type II enzymes could be useful in genetic studies. Genetic engineering based on recombination was pioneered in 1973 by American biochemists Stanley N. Cohen and Herbert W. Boyer, who were among the first to cut DNA into fragments, rejoin different fragments, and insert the new genes into E. coli bacteria, which then reproduced.

Most recombinant DNA technology involves the insertion of foreign genes into the plasmids of common laboratory strains of bacteria. Plasmids are small rings of DNA; they are not part of the bacteriums chromosome (the main repository of the organisms genetic information). Nonetheless, they are capable of directing protein synthesis, and, like chromosomal DNA, they are reproduced and passed on to the bacteriums progeny. Thus, by incorporating foreign DNA (for example, a mammalian gene) into a bacterium, researchers can obtain an almost limitless number of copies of the inserted gene. Furthermore, if the inserted gene is operative (i.e., if it directs protein synthesis), the modified bacterium will produce the protein specified by the foreign DNA.

A subsequent generation of genetic engineering techniques that emerged in the early 21st century centred on gene editing. Gene editing, based on a technology known as CRISPR-Cas9, allows researchers to customize a living organisms genetic sequence by making very specific changes to its DNA. Gene editing has a wide array of applications, being used for the genetic modification of crop plants and livestock and of laboratory model organisms (e.g., mice). The correction of genetic errors associated with disease in animals suggests that gene editing has potential applications in gene therapy for humans.

Genetic engineering has advanced the understanding of many theoretical and practical aspects of gene function and organization. Through recombinant DNA techniques, bacteria have been created that are capable of synthesizing human insulin, human growth hormone, alpha interferon, a hepatitis B vaccine, and other medically useful substances. Plants may be genetically adjusted to enable them to fix nitrogen, and genetic diseases can possibly be corrected by replacing dysfunctional genes with normally functioning genes. Nevertheless, special concern has been focused on such achievements for fear that they might result in the introduction of unfavourable and possibly dangerous traits into microorganisms that were previously free of theme.g., resistance to antibiotics, production of toxins, or a tendency to cause disease. Likewise, the application of gene editing in humans has raised ethical concerns, particularly regarding its potential use to alter traits such as intelligence and beauty.

In 1980 the new microorganisms created by recombinant DNA research were deemed patentable, and in 1986 the U.S. Department of Agriculture approved the sale of the first living genetically altered organisma virus, used as a pseudorabies vaccine, from which a single gene had been cut. Since then several hundred patents have been awarded for genetically altered bacteria and plants. Patents on genetically engineered and genetically modified organisms, particularly crops and other foods, however, were a contentious issue, and they remained so into the first part of the 21st century.

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Genetic engineering in science fiction – Wikipedia

In literature and especially in science fiction, genetic engineering has been used as a theme or a plot device in many stories.[1][2]

In his 1924 essay Daedalus, or Science and the Future, J. B. S. Haldane predicted a day when biologists would invent new algae to feed the world and ectogenetic children would be created and modified using eugenic selection. Aldous Huxley developed these ideas in a satirical direction for his 1932 novel Brave New World, in which ectogenetic embryos were developed in selected environments to create children of an ‘Alpha’, ‘Beta’, or ‘Gamma’ type.[3]

The advent of large-scale genetic engineering has increased its presence in fiction.[4][5] Genetics research consortia, such as the Wellcome Trust Sanger Institute, have felt the need to distinguish genetic engineering fact from fiction in explaining their work to the public,[1] and have explored the role that genetic engineering has played in the public perception of programs, such as the Human Genome Project.[6]

Beyond the usual library catalog classifications,[7] the Wellcome Trust Sanger Institute[1] and the NHGRI[6] have compiled catalogs of literature in various media with genetics and genetic engineering as a theme or plot device. Such compilations are also available at fan sites.[8]

In the 2000 television series Andromeda, the Nietzscheans (Homo sapiens invictus in Latin) are a race of genetically engineered humans who religiously follow the works of Friedrich Nietzsche, social Darwinism and Dawkinite genetic competitiveness. They claim to be physically perfect and are distinguished by bone blades protruding outwards from the wrist area.

In the book 2312 by Kim Stanley Robinson, genetic engineering of humans, plants and animals and how that affects a society spread over the solar system is explored.

In the Animorphs book series, race of aliens known as the Hork-Bajir were engineered by a race known as the Arns. Another race, the Iskhoots, are another example of genetic engineering. The outer body, the Isk, was created by the Yoort, who also modify themselves to be symbotic to the Isk. Also, a being known as the Ellimist has made species such as the Pemalites by this method.

In the 1983 film Anna to the Infinite Power, the main character was one of seven genetically cloned humans created by Anna Zimmerman as a way to groom a perfect person in her image. After her death, her work was carried on by her successor Dr. Henry Jelliff, who had other plans for the project. But in the end we learn that her original genetic creation, Michaela Dupont, has already acquired her creator’s abilities, including how to build a genetic replicator from scratch.

The 1996 video game series Resident Evil involves the creation of genetically engineered viruses which turn humans and animals into organisms such as zombies, the Tyrants or Hunters by a worldwide pharmaceutical company called the Umbrella Corporation.

In the video game series BioShock, most of the enemies in both BioShock and BioShock 2, referred to as “splicers”, as well as the player, gain superpowers and enhance their physical and mental capabilities by means of genetically engineered plasmids, created by use of ADAM stem cells secreted by a species of sea slug.[9]

The novel Beggars in Spain by Nancy Kress and its sequels are widely recognized by science fiction critics as among the most sophisticated fictional treatments of genetic engineering. They portray genetically-engineered characters whose abilities are far greater than those of ordinary humans (e.g. they are effectively immortal and they function without needing to sleep). At issue is what responsibility they have to use their abilities to help “normal” human beings. Kress explores libertarian and more collectivist philosophies, attempting to define the extent of people’s mutual responsibility for each other’s welfare.

In the Battletech science fiction series, the Clans have developed a genetic engineering program for their warriors, consisting of eugenics and the use of artificial wombs.

In The Champion Maker, a novel by Kevin Joseph, a track coach and a teenage phenom stumble upon a dark conspiracy involving genetic engineering while pursuing Olympic gold.

In the CoDominium series, the planet Sauron develops a supersoldier program. The result were the Sauron Cyborgs, and soldiers. The Cyborgs, who made up only a very small part of the population of Sauron, were part highly genetically engineered human, and part machine. Cyborgs held very high status in Sauron society.

Sauron soldiers, who made up the balance of the population, were the result of generations of genetic engineering. The Sauron soldiers had a variety of physical characteristics and abilities that made the soldiers the best in combat and survival in many hostile environments. For instance, their bones were stronger than unmodified humans. Their lungs extract oxygen more efficiently than normal unmodified humans, allowing them to exert themselves without getting short of breath, or function at high altitudes. Sauron soldiers also have the ability to change the focal length of their eyes, so that they can “zoom” in on a distant object, much like an eagle.

The alien Moties also have used genetic engineering.

In the science fiction series Crest of the Stars, the Abh are a race of genetically engineered humans, who continue to practice the technology. All Abh have been adapted to live in zero-gravity environments, with the same features such as beauty, long life, lifelong youthful appearance, blue hair, and a “space sensory organ”.

In the 2000 TV series Dark Angel, the main character Max is one of a group of genetically engineered supersoldiers spliced with feline DNA.

In military science fiction 1993 television series Exosquad, the plot revolves around the conflict between Terrans (baseline humans) and Neosapiens, a race of genetically engineered sentient (and sterile) humanoids, who were originally bred for slave labour but revolted under the leadership of Phaeton and captured the Homeworlds (Earth, Venus and Mars). During the war, various sub-broods of Neosapiens were invented, such as, Neo Megas (intellectually superior to almost any being in the Solar System), Neo Warriors (cross-breeds with various animals) and Neo Lords (the ultimate supersoldiers).

Genetic modification is also found in the 2002 anime series Gundam SEED. It features enhanced humans called Coordinators who were created from ordinary humans through genetic modification.

In Marvel Comics, the 31st century adventurers called the Guardians of the Galaxy are genetically engineered residents of Mercury, Jupiter, and Pluto.

The 1997 film Gattaca deals with the idea of genetic engineering and eugenics as it projects what class relations would look like in a future society after a few generations of the possibility of genetic engineering.

In Marvel Comics, the Inhumans are the result of genetic engineering of early humans by the Kree alien race.

Rather than deliberate engineering, this 2017 novel by British author Steve Turnbull features a plague that carries genetic material across species, causing a wide variety of mutations. Human attempts to control this plague have resulted in a fascist dystopia.

In the Leviathan universe, a group known as the Darwinists use genetically engineered animals as weapons.

The 2000AD strip, Lobster Random features a former soldier-turned-torturer, who has been modified to not feel pain or need to sleep and has a pair of lobster claws grafted to his hips. This state has left him somewhat grouchy.

In Metal Gear Solid, the Genome Army were given gene therapy enhancements.

Also in the series, the Les Enfants Terribles project involved genetic engineering.

The Moreau series by S. Andrew Swann has as the central premise the proliferation of humanoid genetically-engineered animals. The name of the series (and of the creatures themselves) comes from the H. G. Wells novel The Island of Dr. Moreau. In the Wells novel, humanoid animals were created surgically, though this detail has been changed to be genetic manipulation in most film adaptations.

The Neanderthal Parallax novel by Robert J. Sawyer depicts a eugenic society that has benefitted immensely from the sterilization of dangerous criminals as well as preventing the 5% least intelligent from procreating for ten generations.

In the Neon Genesis Evangelion anime series, the character Rei Ayanami is implied to be a lab-created being combining human and angelic DNA. (compare to the Biblical Nephilim)

Genetic engineering (or something very like it) features prominently in Last and First Men, a 1930 novel by Olaf Stapledon.

Genetic engineering is depicted as widespread in the civilized world of Oryx and Crake. Prior to the apocalypse, though, its use among humans is not mentioned. Author Margaret Atwood describes many transgenic creatures such as Pigoons (though originally designed to be harvested for organs, post-apocalyptic-plague, they become more intelligent and vicious, traveling in packs), Snats (snake-rat hybrids who may or may not be extinct), wolvogs (wolf-dog hybrids), and the relatively harmless “rakunks” (skunk-raccoon hybrids, originally designed as pets with no scent glands).

In Plague, a 1978 film, a bacterium in an agricultural experiment accidentally escapes from a research laboratory in Canada, reaching the American Northeast and Great Britain.

Using a method similar to the DNA Resequencer from Stargate SG-1, and even called DNA Resequencing, the Operation Overdrive Power Rangers were given powers of superhuman strength, enhanced hearing, enhanced eyesight, super bouncing, super speed, and invisibility.

Quake II and Quake 4, released in 1997 and 2005, contain genetically-engineered Stroggs.

In the long-running 2006 series Rogue Trooper, the eponymous hero is a Genetic Infantryman, one of an elite group of supersoldiers genetically modified to resist the poisons left in the Nu-Earth atmosphere by decades of war. The original concept from the pages of 80s cult sci-fi comic 2000 AD (of Judge Dredd fame).

James Blish’s The Seedling Stars (1956) is the classic story of controlled mutation for adaptability. In this novel (originally a series of short stories) the Adapted Men are reshaped human beings, designed for life on a variety of other planets. This is one of science fiction’s most unreservedly optimistic accounts to date of technological efforts to reshape human beings.

In “The Man Who Grew Too Much” episode (2014), Sideshow Bob steals DNA from a GMO company, thus making himself the very first genetically engineered human, and attempts to combine his DNA with that of the smartest people ever to exist on Earth.

In Sleeper, a 1973 parody of many science fiction tropes, genetically modified crops are shown to grow gigantic.

The short-lived 1990s television series Space: Above and Beyond includes a race of genetically engineered and artificially gestated humans who are born at the physical age of 18, and are collectively known as InVitros or sometimes, derogatorily, “tanks” or “nipple-necks”. At the time of the series storyline, this artificial human race was integrated with the parent species, but significant discrimination still occurred.

The Ultimate Life Form project that produced Shadow the Hedgehog and Biolizard in the Sonic the Hedgehog series was a genetic engineering project.

In the Star Trek universe, genetic engineering has featured in a couple of films, and a number of television episodes.

The Breen, the Dominion, Species 8472, the Xindi, and the Federation use technology with organic components.

Khan Noonien Singh, who appeared in Space Seed and Star Trek II: The Wrath of Khan, was a product of genetic engineering. His physical structure was modified to make him stronger and to give him greater stamina than a regular human. His mind was also enhanced. However, the creation of Khan would have serious consequences because the superior abilities given to him created superior ambition. Along with other enhanced individuals, they tried to take over the planet. When they were reawakened by the Enterprise, Khan set himself to taking over the universe. Later, he became consumed by grief and rage, and set himself on the goal of destroying Kirk.

Others of these genetically enhanced augments wreaked havoc in the 22nd century, and eventually some of their enhanced DNA was blended with Klingon DNA, creating the human-looking Klingons of the early 23rd century (See Star Trek: Enterprise episodes “Affliction” and “Divergence”).

Because of the experiences with genetic engineering, the Federation had banned it except to correct genetic birth defects, but a number of parents still illegally subjected their children to genetic engineering for a variety of reasons. This often created brilliant but unstable individuals. Such children are not allowed to serve in Starfleet or practice medicine, though Julian Bashir is a notable exception to this. Despite the ban, the Federation allowed the Darwin station to conduct human genetic engineering, which resulted in a telepathic, telekentic humans with a very effective immune system.

In Attack of the Clones, the Kamino cloners who created the clone army for the Galactic Republic had used engineering to enhance their clones. They modified the genetic structure of all but one to accelerate their growth rate, make them less independent, and make them better suited to combat operations.

Later, the Yuuzhan Vong are a race who exclusively use organic technology and regard mechanical technology as heresy. Everything from starships to communications devices to weapons are bred and grown to suit their needs.

In the show Stargate SG-1, the DNA Resequencer was a device built by the Ancients, designed to make extreme upgrades to humans by realigning their DNA and upgrading their brain activity. The machine gave them superhuman abilities, such as telekensis, telepathy, precognition, superhuman senses, strength, and intellect, the power to heal at an incredible rate, and the power to heal others by touch.

In the futuristic tabletop and video game series, Warhammer 40,000, the Imperium of Man uses genetic engineering to enhance the abilities of various militant factions such as the Space Marines, the Grey Knights, and the Adeptus Custodes. A sample or a synthesized version of the gene seed, a “part” of the original Primarch’s or leaders DNA is used in the transformation of these superhuman warriors.

At the same time, the Tau Empire uses a form of eugenic breeding to improve the physical and mental condition of its various castes.

In the e-book, Methuselah’s Virus, an ageing pharmaceutical billionaire accidentally creates a contagious virus capable of infecting people with extreme longevity when his genetic engineering experiment goes wrong. The novel then examines the problem of what happens if Methuselah’s Virus is at risk of spreading to everyone on the entire planet.

In World Hunger, author Brian Kenneth Swain paints the harrowing picture of a life sciences company that field tests a new strain of genetically modified crop, the unexpected side effect of which is the creation of several new species of large and very aggressive insects.

Genetic engineering is an essential theme of the illustrated book Man After Man: An Anthropology of the Future by Dougal Dixon, where it is used to colonize other star systems and save the humans of Earth from extinction.

The Survival Gene e-book contains the author Artsun Akopyan’s idea that people can’t preserve nature as it is forever, so they’ll have to change their own genetics in the future or die. In the novel, wave genetics is used to save humankind and all life on Earth.

A series of books by David Brin in which humans have encountered the Five Galazies, a multitude of sentient species which all practice Uplift raising species to sapience through genetic engineering. Humans, believing they have risen to sapience through evolution alone, are seen as heretics. But they have some status because at the time of contact humans had already Uplifted two species chimpanzees and bottlenose dolphins.

Eugenics is a recurrent theme in science fiction, often with both dystopian and utopian elements. The two giant contributions in this field are the novel Brave New World (1932) by Aldous Huxley, which describes a society where control of human biology by the state results in permanent social stratification.

There tends to be a eugenic undercurrent in the science fiction concept of the supersoldier. Several depictions of these supersoldiers usually have them bred for combat or genetically selected for attributes that are beneficial to modern or future combat.

The Brave New World theme also plays a role in the 1997 film Gattaca, whose plot turns around reprogenetics, genetic testing, and the social consequences of eugenics. Boris Vian (under the pseudonym Vernon Sullivan) takes a more light-hearted approach in his novel Et on tuera tous les affreux (“And we’ll kill all the ugly ones”).

Other novels touching upon the subject include The Gate to Women’s Country by Sheri S. Tepper and That Hideous Strength by C. S. Lewis. The Eugenics Wars are a significant part of the background story of the Star Trek universe (episodes “Space Seed”, “Borderland”, “Cold Station 12”, “The Augments” and the film Star Trek II: The Wrath of Khan). Eugenics also plays a significant role in the Neanderthal Parallax trilogy where eugenics-practicing Neanderthals from a near-utopian parallel world create a gateway to earth. Cowl by Neal Asher describes the collapse of western civilization due to dysgenics. Also Eugenics is the name for the medical company in La Foire aux immortels book by Enki Bilal and on the Immortel (Ad Vitam) movie by the same author.

In Frank Herbert’s Dune series of novels, selective breeding programs form a significant theme. Early in the series, the Bene Gesserit religious order manipulates breeding patterns over many generations in order to create the Kwisatz Haderach. In God Emperor of Dune, the emperor Leto II again manipulates human breeding in order to achieve his own ends. The Bene Tleilaxu also employed genetic engineering to create human beings with specific genetic attributes. The Dune series ended with causal determinism playing a large role in the development of behavior, but the eugenics theme remained a crucial part of the story.

In Orson Scott Card’s novel Ender’s Game, Ender is only allowed to be conceived because of a special government exception due to his parent’s high intelligence and the extraordinary performance of his siblings. In Ender’s Shadow, Bean is a test-tube baby and the result of a failed eugenics experiment aimed at creating child geniuses.

In the novels Methuselah’s Children and Time Enough for Love by Robert A. Heinlein, a large trust fund is created to give financial encouragement to marriage among people (the Howard Families) whose parents and grandparents were long lived. The result is a subset of Earth’s population who has significantly above-average life spans. Members of this group appear in many of the works by the same author.

In the 1982 Robert Heinlein novel Friday, the main character has been genetically engineered from multiple sets of donors, including, as she finds out later her boss. These enhancements give her superior strength, speed, eyesight in addition to healing and other advanced attributes. Creations like her are considered to be AP’s (Artificial Person).

In Eoin Colfer’s book The Supernaturalist, Ditto is a Bartoli Baby, which is the name for a failed experiment of the famed Dr. Bartoli. Bartoli tried to create a superior race of humans, but they ended in arrested development, with mutations including extrasensory perception and healing hands.

In Larry Niven’s Ringworld series, the character Teela Brown is a result of several generations of winners of the “Birthright Lottery”, a system which attempts to encourage lucky people to breed, treating good luck as a genetic trait.

In season 2 of Dark Angel, the main ‘bad guy’ Ames White is a member of a cult known as the Conclave which has infiltrated various levels of society to breed super-humans. They are trying to exterminate all the Transgenics, including the main character Max Guevara, whom they view as being genetically unclean for having some animal DNA spliced with human.

In the movie Immortel (Ad Vitam), Director/Writer Enki Bilal titled the name of the evil corrupt organization specializing in genetic manipulation, and some very disturbing genetic “enhancement” eugenics. Eugenics has come to be a powerful organization and uses people and mutants of “lesser” genetic stock as guinea pigs. The movie is based on the Nikopol trilogy in Heavy Metal comic books.

In the video game Grand Theft Auto: Vice City, a fictional character called Pastor Richards, a caricature of an extreme and insane televangelist, is featured as a guest on a discussion radio show about morality. On this show, he describes shooting people who do not agree with him and who are not “morally correct”, which the show’s host describes as “amateur eugenics”.

In the 2006 Mike Judge film Idiocracy, a fictional character, pvt. Joe Bauers, aka Not Sure (played by Luke Wilson), awakens from a cryogenic stasis in the year 2505 into a world devastated by dysgenic degeneration. Bauers, who was chosen for his averageness, is discovered to be the smartest human alive and eventually becomes president of the United States.

The manga series Battle Angel Alita and its sequel Battle Angel Alita: Last Order (Gunnm and Gunnm: Last Order as it is known in Japan) by Yukito Kishiro, contains multiple references to the theme of eugenics. The most obvious is the sky city Tiphares (Salem in Japanese edition). Dr. Desty Nova, in the first series in Volume 9, reveals the eugenical nature of the city to Alita (Gally or Yoko) and it is further explored in the sequel series. A James Cameron movie based on the series is due for release on 2018.[10]

In the French 2000 police drama Crimson Rivers, inspectors Pierre Niemans (played by Jean Reno) and his colleague Max Kerkerian (Vincent Cassel) attempt to solve series of murders triggered by eugenics experiment that was going on for years in university town of Guernon.

In the Cosmic Era universe of the Gundam anime series (Mobile Suit Gundam SEED), war is fought between the normal human beings without genetic enhancements, also known as the Naturals, and the Coordinators, who are genetically enhanced. It explores the pros and cons as well as possible repercussions from Eugenics

The Khommites of planet Khomm practice this through the method of self-cloning, believing they are perfect.

The book Uglies, part of a four-book series by Scott Westerfeld, revolves around a girl named Tally who lives in a world where everyone at the age of sixteen receives extensive cosmetic surgery to turn into “Pretties” and join society. Although it deals with extreme cosmetic surgery, the utopian (or dystopian, depending on one’s interpretation) ideals in the book are similar to those present in the books mentioned above.

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Genetic engineering in science fiction – Wikipedia

Genetic Engineering: What is Genetic Engineering?

Written by Patrick Dixon

Futurist Keynote Speaker: Posts, Slides, Videos – BioTech, MedTech, Gene Therapy and Stem Cells

Video on Genetic Engineering

Genetic engineering is the alteration of genetic code by artificial means, and is therefore different from traditional selective breeding.

Huge number of other resources on this site about Genetic engineering.

Genetic engineering examples include taking the gene that programs poison in the tail of a scorpion, and combining it with a cabbage. These genetically modified cabbages kill caterpillers because they have learned to grow scorpion poison (insecticide) in their sap.

Genetic engineering also includes insertion of human genes into sheep so that they secrete alpha-1 antitrypsin in their milk – a useful substance in treating some cases of lung disease.

Genetic engineering has created a chicken with four legs and no wings.

Genetic engineering has created a goat with spider genes that creates “silk” in its milk.

Genetic engineering works because there is one language of life: human genes work in bacteria, monkey genes work in mice and earthworms. Tree genes work in bananas and frog genes work in rice. There is no limit in theory to the potential of genetic engineering.

Genetic engineering has given us the power to alter the very basis of life on earth.

Genetic engineering has been said to be no different than ancient breeding methods but this is untrue. For a start, breeding or cross-breeding, or in-breeding (for example to make pedigree dogs) all work by using the same species. In contrast genetic engineering allows us to combine fish, mouse, human and insect genes in the same person or animal.

Genetic engineering therefore has few limits – except our imagination, and our moral or ethical code.

Genetic engineering makes the whole digital revolution look nothing. Digital technology changes what we do. Genetic engineering has the power to change who we are.

Human cloning is a type of genetic engineering, but is not the same as true genetic manipulation. In human cloning, the aim is to duplicate the genes of an existing person so that an identical set is inside a human egg. The result is intended to be a cloned twin, perhaps of a dead child. Genetic engineering in its fullest form would result in the child produced having unique genes – as a result of laboratory interference, and therefore the child will not be an identikit twin.

Genetic engineering could create crops that grow in desert heat, or without fertiliser. Genetic engineering could make bananas or other fruit which contain vaccines or other medical products.

Genetic engineering is helped by the fact that it only costs $1000 to analyse someone’s genetic code (sequencing of genome) – down from $800m in 2001.

Genetic engineering is aided by techniques such as Crispr which allow scientists to swop genes between humans or between animals and humans or between animals, in a very precise and controlled way.

Genetic engineering will alter the basis of life on earth – permanently – unless controlled. This could happen if – say – mutant viruses, or bacteria, or fish or reptiles are released into the general environment.

READ FREE BOOK on Genetic Engineering – by Patrick Dixon, author of 16 books and creator of this website – read now: Chapters 1 and 2 explain basics in way which is easy to understand.

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Genetic Engineering: What is Genetic Engineering?

Genetic Engineering Is the New Nuke – TV Tropes

“Biotechnology promises the greatest revolution in human history. By the end of this decade, it will have outdistanced atomic power and computers in its effect on our everyday lives.”Once upon a time, superheroes inevitably gained their superpowers from radiation, the latest and most mysterious-yet-powerful fad of the 50s and 60s.Technology Marches On, however, and gene splicing has replaced atom smashing as the most glamorous sciencey stuff: nowadays, many modern remakes of classic superheroes go with Genetic Engineering. Be it a bite from a genetically engineered spider, or exposure to it in a freak accident, genetically engineered origins are the Phlebotinum for the 21st century. It is worth noting that in Real Life rarely are the effects of genetic engineering anything like those portrayed in speculative fiction yet.Genetic Engineering also lends itself to being weaponized to do exactly the same thing as those ultracool nukes that kill people but leave buildings standing. Now that a nuclear apocalypse is substantially less likely (or at least less likely to wipe us all out), and chemical weapons just aren’t destructive enough in terms of human life, biological weapons make a nice scary (and vague) alternative.May lead to Bio-Augmentation and Mutants. Superpowerful Genetics may either come from this, or have a hand on the engineering overall.It’s also interesting to note the other favourite sources of weirdness used by SF writers before the advent of nuclear physics.

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Dr. Lambha: “God damn you idiots in the media! I’m doing research on spider genetics, and you infer that I’m going to cure fatness or turn people into spidermen! Do you understand nothing about science?”

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Genetic engineering will eliminate some of the most horrific things that can happen to anyone, ever, and make everyone better at everything as a mere side effect. Anyone campaigning against genetic engineering is saying, “I was lucky enough not to get cystic fibrosis, Tay-Sachs, or any one of a hundred other unthinkable horrors, and that’s 100 percent of the humans I care about! Yay!”

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Genetic Engineering Is the New Nuke – TV Tropes

Genetic Engineering in Agriculture | Union of Concerned …

While the risks of genetic engineering are often exaggerated or misrepresented, GE crops do have the potential to cause a variety of health problems and environmental impacts. For instance, they may spread undesirable traits to weeds and non-GE crops, produce new allergens and toxins, or harm animals that consume them.

At least one major environmental impact of genetic engineering has already reached critical proportions: overuse of herbicide-tolerant GE crops has spurred an increase in herbicide use and an epidemic of herbicide-resistant “superweeds,” which will lead to even more herbicide use.

How likely are other harmful GE impacts to occur? This is a difficult question to answer. Each crop-gene combination poses its own set of risks. While risk assessments are conducted as part of GE product approval, the data are generally supplied by the company seeking approval, and GE companies use their patent rights to exercise tight control over research on their products.

In short, there is a lot we don’t know about the long-term and epidemiological risks of GEwhich is no reason for panic, but a good reason for caution, particularly in view of alternatives that are more effective and economical.

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Genetic Engineering in Agriculture | Union of Concerned …

Genetic engineering – Wikipedia

Genetic engineering, also called genetic modification, is the direct manipulation of an organism’s genes using biotechnology. It is a set of technologies used to change the genetic makeup of cells, including the transfer of genes within and across species boundaries to produce improved or novel organisms. New DNA is obtained by either isolating and copying the genetic material of interest using recombinant DNA methods or by artificially synthesising the DNA. A construct is usually created and used to insert this DNA into the host organism. The first recombinant DNA molecule was made by Paul Berg in 1972 by combining DNA from the monkey virus SV40 with the lambda virus. As well as inserting genes, the process can be used to remove, or “knock out”, genes. The new DNA can be inserted randomly, or targeted to a specific part of the genome.

An organism that is generated through genetic engineering is considered to be genetically modified (GM) and the resulting entity is a genetically modified organism (GMO). The first GMO was a bacterium generated by Herbert Boyer and Stanley Cohen in 1973. Rudolf Jaenisch created the first GM animal when he inserted foreign DNA into a mouse in 1974. The first company to focus on genetic engineering, Genentech, was founded in 1976 and started the production of human proteins. Genetically engineered human insulin was produced in 1978 and insulin-producing bacteria were commercialised in 1982. Genetically modified food has been sold since 1994, with the release of the Flavr Savr tomato. The Flavr Savr was engineered to have a longer shelf life, but most current GM crops are modified to increase resistance to insects and herbicides. GloFish, the first GMO designed as a pet, was sold in the United States in December 2003. In 2016 salmon modified with a growth hormone were sold.

Genetic engineering has been applied in numerous fields including research, medicine, industrial biotechnology and agriculture. In research GMOs are used to study gene function and expression through loss of function, gain of function, tracking and expression experiments. By knocking out genes responsible for certain conditions it is possible to create animal model organisms of human diseases. As well as producing hormones, vaccines and other drugs genetic engineering has the potential to cure genetic diseases through gene therapy. The same techniques that are used to produce drugs can also have industrial applications such as producing enzymes for laundry detergent, cheeses and other products.

The rise of commercialised genetically modified crops has provided economic benefit to farmers in many different countries, but has also been the source of most of the controversy surrounding the technology. This has been present since its early use, the first field trials were destroyed by anti-GM activists. Although there is a scientific consensus that currently available food derived from GM crops poses no greater risk to human health than conventional food, GM food safety is a leading concern with critics. Gene flow, impact on non-target organisms, control of the food supply and intellectual property rights have also been raised as potential issues. These concerns have led to the development of a regulatory framework, which started in 1975. It has led to an international treaty, the Cartagena Protocol on Biosafety, that was adopted in 2000. Individual countries have developed their own regulatory systems regarding GMOs, with the most marked differences occurring between the USA and Europe.

Genetic engineering is a process that alters the genetic make-up of an organism by either removing or introducing DNA. Unlike traditionally animal and plant breeding, which involves doing multiple crosses and then selecting for the organism with the desired phenotype, genetic engineering takes the gene directly from one organism and inserts it in the other. This is much faster, can be used to insert any genes from any organism (even ones from different domains) and prevents other undesirable genes from also being added.[1]

Genetic engineering could potentially fix severe genetic disorders in humans by replacing the defective gene with a functioning one.[2] It is an important tool in research that allows the function of specific genes to be studied.[3] Drugs, vaccines and other products have been harvested from organisms engineered to produce them.[4] Crops have been developed that aid food security by increasing yield, nutritional value and tolerance to environmental stresses.[5]

The DNA can be introduced directly into the host organism or into a cell that is then fused or hybridised with the host.[6] This relies on recombinant nucleic acid techniques to form new combinations of heritable genetic material followed by the incorporation of that material either indirectly through a vector system or directly through micro-injection, macro-injection or micro-encapsulation.[7]

Genetic engineering does not normally include traditional breeding, in vitro fertilisation, induction of polyploidy, mutagenesis and cell fusion techniques that do not use recombinant nucleic acids or a genetically modified organism in the process.[6] However, some broad definitions of genetic engineering include selective breeding.[7] Cloning and stem cell research, although not considered genetic engineering,[8] are closely related and genetic engineering can be used within them.[9] Synthetic biology is an emerging discipline that takes genetic engineering a step further by introducing artificially synthesised material into an organism.[10]

Plants, animals or micro organisms that have been changed through genetic engineering are termed genetically modified organisms or GMOs.[11] If genetic material from another species is added to the host, the resulting organism is called transgenic. If genetic material from the same species or a species that can naturally breed with the host is used the resulting organism is called cisgenic.[12] If genetic engineering is used to remove genetic material from the target organism the resulting organism is termed a knockout organism.[13] In Europe genetic modification is synonymous with genetic engineering while within the United States of America and Canada genetic modification can also be used to refer to more conventional breeding methods.[14][15][16]

Humans have altered the genomes of species for thousands of years through selective breeding, or artificial selection[19]:1[20]:1 as contrasted with natural selection, and more recently through mutagenesis. Genetic engineering as the direct manipulation of DNA by humans outside breeding and mutations has only existed since the 1970s. The term “genetic engineering” was first coined by Jack Williamson in his science fiction novel Dragon’s Island, published in 1951[21] one year before DNA’s role in heredity was confirmed by Alfred Hershey and Martha Chase,[22] and two years before James Watson and Francis Crick showed that the DNA molecule has a double-helix structure though the general concept of direct genetic manipulation was explored in rudimentary form in Stanley G. Weinbaum’s 1936 science fiction story Proteus Island.[23][24]

In 1972, Paul Berg created the first recombinant DNA molecules by combining DNA from the monkey virus SV40 with that of the lambda virus.[25] In 1973 Herbert Boyer and Stanley Cohen created the first transgenic organism by inserting antibiotic resistance genes into the plasmid of an Escherichia coli bacterium.[26][27] A year later Rudolf Jaenisch created a transgenic mouse by introducing foreign DNA into its embryo, making it the worlds first transgenic animal.[28] These achievements led to concerns in the scientific community about potential risks from genetic engineering, which were first discussed in depth at the Asilomar Conference in 1975. One of the main recommendations from this meeting was that government oversight of recombinant DNA research should be established until the technology was deemed safe.[29][30]

In 1976 Genentech, the first genetic engineering company, was founded by Herbert Boyer and Robert Swanson and a year later the company produced a human protein (somatostatin) in E.coli. Genentech announced the production of genetically engineered human insulin in 1978.[31] In 1980, the U.S. Supreme Court in the Diamond v. Chakrabarty case ruled that genetically altered life could be patented.[32] The insulin produced by bacteria was approved for release by the Food and Drug Administration (FDA) in 1982.[33]

In 1983, a biotech company, Advanced Genetic Sciences (AGS) applied for U.S. government authorisation to perform field tests with the ice-minus strain of Pseudomonas syringae to protect crops from frost, but environmental groups and protestors delayed the field tests for four years with legal challenges.[34] In 1987, the ice-minus strain of P. syringae became the first genetically modified organism (GMO) to be released into the environment[35] when a strawberry field and a potato field in California were sprayed with it.[36] Both test fields were attacked by activist groups the night before the tests occurred: “The world’s first trial site attracted the world’s first field trasher”.[35]

The first field trials of genetically engineered plants occurred in France and the USA in 1986, tobacco plants were engineered to be resistant to herbicides.[37] The Peoples Republic of China was the first country to commercialise transgenic plants, introducing a virus-resistant tobacco in 1992.[38] In 1994 Calgene attained approval to commercially release the first genetically modified food, the Flavr Savr, a tomato engineered to have a longer shelf life.[39] In 1994, the European Union approved tobacco engineered to be resistant to the herbicide bromoxynil, making it the first genetically engineered crop commercialised in Europe.[40] In 1995, Bt Potato was approved safe by the Environmental Protection Agency, after having been approved by the FDA, making it the first pesticide producing crop to be approved in the USA.[41] In 2009 11 transgenic crops were grown commercially in 25 countries, the largest of which by area grown were the USA, Brazil, Argentina, India, Canada, China, Paraguay and South Africa.[42]

In 2010, scientists at the J. Craig Venter Institute created the first synthetic genome and inserted it into an empty bacterial cell. The resulting bacterium, named Mycoplasma laboratorium, could replicate and produce proteins.[43][44] Four years later this was taken a step further when bacterium was developed that replicated a plasmid containing a unique base pair, creating the first organism engineered to use an expanded genetic alphabet.[45][46] In 2012, Jennifer Doudna and Emmanuelle Charpentier collaborated to develop the CRISPR/Cas9 system,[47][48] a technique which can be used to easily and specifically alter the genome of almost any organism.[49]

Creating a GMO is a multi-step process. Genetic engineers must first choose what gene they wish to insert into the organism. This is driven by what the aim is for the resultant organism and is built on earlier research. Genetic screens can be carried out to determine potential genes and further tests then used to identify the best candidates. The development of microarrays, transcriptomes and genome sequencing has made it much easier to find suitable genes.[50] Luck also plays its part; the round-up ready gene was discovered after scientists noticed a bacterium thriving in the presence of the herbicide.[51]

The next step is to isolate the candidate gene. The cell containing the gene is opened and the DNA is purified.[52] The gene is separated by using restriction enzymes to cut the DNA into fragments[53] or polymerase chain reaction (PCR) to amplify up the gene segment.[54] These segments can then be extracted through gel electrophoresis. If the chosen gene or the donor organism’s genome has been well studied it may already be accessible from a genetic library. If the DNA sequence is known, but no copies of the gene are available, it can also be artificially synthesised.[55] Once isolated the gene is ligated into a plasmid that is then inserted into a bacterium. The plasmid is replicated when the bacteria divide, ensuring unlimited copies of the gene are available.[56]

Before the gene is inserted into the target organism it must be combined with other genetic elements. These include a promoter and terminator region, which initiate and end transcription. A selectable marker gene is added, which in most cases confers antibiotic resistance, so researchers can easily determine which cells have been successfully transformed. The gene can also be modified at this stage for better expression or effectiveness. These manipulations are carried out using recombinant DNA techniques, such as restriction digests, ligations and molecular cloning.[57]

There are a number of techniques available for inserting the gene into the host genome. Some bacteria can naturally take up foreign DNA. This ability can be induced in other bacteria via stress (e.g. thermal or electric shock), which increases the cell membrane’s permeability to DNA; up-taken DNA can either integrate with the genome or exist as extrachromosomal DNA. DNA is generally inserted into animal cells using microinjection, where it can be injected through the cell’s nuclear envelope directly into the nucleus, or through the use of viral vectors.[58]

In plants the DNA is often inserted using Agrobacterium-mediated recombination,[59] taking advantage of the Agrobacteriums T-DNA sequence that allows natural insertion of genetic material into plant cells.[60] Other methods include biolistics, where particles of gold or tungsten are coated with DNA and then shot into young plant cells,[61] and electroporation, which involves using an electric shock to make the cell membrane permeable to plasmid DNA. Due to the damage caused to the cells and DNA the transformation efficiency of biolistics and electroporation is lower than agrobacterial transformation and microinjection.[62]

As only a single cell is transformed with genetic material, the organism must be regenerated from that single cell. In plants this is accomplished through the use of tissue culture.[63][64] In animals it is necessary to ensure that the inserted DNA is present in the embryonic stem cells.[65] Bacteria consist of a single cell and reproduce clonally so regeneration is not necessary. Selectable markers are used to easily differentiate transformed from untransformed cells. These markers are usually present in the transgenic organism, although a number of strategies have been developed that can remove the selectable marker from the mature transgenic plant.[66]

Further testing using PCR, Southern hybridization, and DNA sequencing is conducted to confirm that an organism contains the new gene.[67] These tests can also confirm the chromosomal location and copy number of the inserted gene. The presence of the gene does not guarantee it will be expressed at appropriate levels in the target tissue so methods that look for and measure the gene products (RNA and protein) are also used. These include northern hybridisation, quantitative RT-PCR, Western blot, immunofluorescence, ELISA and phenotypic analysis.[68]

The new genetic material can be inserted randomly within the host genome or targeted to a specific location. The technique of gene targeting uses homologous recombination to make desired changes to a specific endogenous gene. This tends to occur at a relatively low frequency in plants and animals and generally requires the use of selectable markers. The frequency of gene targeting can be greatly enhanced through genome editing. Genome editing uses artificially engineered nucleases that create specific double-stranded breaks at desired locations in the genome, and use the cells endogenous mechanisms to repair the induced break by the natural processes of homologous recombination and nonhomologous end-joining. There are four families of engineered nucleases: meganucleases,[69][70] zinc finger nucleases,[71][72] transcription activator-like effector nucleases (TALENs),[73][74] and the Cas9-guideRNA system (adapted from CRISPR).[75][76] TALEN and CRISPR are the two most commonly used and each has its own advantages.[77] TALENs have greater target specificity, while CRISPR is easier to design and more efficient.[77] In addition to enhancing gene targeting, engineered nucleases can be used to introduce mutations at endogenous genes that generate a gene knockout.[78][79]

Genetic engineering has applications in medicine, research, industry and agriculture and can be used on a wide range of plants, animals and micro organisms. Bacteria, the first organisms to be genetically modified, can have plasmid DNA inserted containing new genes that code for medicines or enzymes that process food and other substrates.[80][81] Plants have been modified for insect protection, herbicide resistance, virus resistance, enhanced nutrition, tolerance to environmental pressures and the production of edible vaccines.[82] Most commercialised GMOs are insect resistant or herbicide tolerant crop plants.[83] Genetically modified animals have been used for research, model animals and the production of agricultural or pharmaceutical products. The genetically modified animals include animals with genes knocked out, increased susceptibility to disease, hormones for extra growth and the ability to express proteins in their milk.[84]

Genetic engineering has many applications to medicine that include the manufacturing of drugs, creation of model animals that mimic human conditions and gene therapy. One of the earliest uses of genetic engineering was to mass-produce human insulin in bacteria.[31] This application has now been applied to, human growth hormones, follicle stimulating hormones (for treating infertility), human albumin, monoclonal antibodies, antihemophilic factors, vaccines and many other drugs.[85][86] Mouse hybridomas, cells fused together to create monoclonal antibodies, have been adapted through genetic engineering to create human monoclonal antibodies.[87] In 2017, genetic engineering of chimeric antigen receptors on a patient’s own T-cells was approved by the U.S. FDA as a treatment for the cancer acute lymphoblastic leukemia. Genetically engineered viruses are being developed that can still confer immunity, but lack the infectious sequences.[88]

Genetic engineering is also used to create animal models of human diseases. Genetically modified mice are the most common genetically engineered animal model.[89] They have been used to study and model cancer (the oncomouse), obesity, heart disease, diabetes, arthritis, substance abuse, anxiety, aging and Parkinson disease.[90] Potential cures can be tested against these mouse models. Also genetically modified pigs have been bred with the aim of increasing the success of pig to human organ transplantation.[91]

Gene therapy is the genetic engineering of humans, generally by replacing defective genes with effective ones. Clinical research using somatic gene therapy has been conducted with several diseases, including X-linked SCID,[92] chronic lymphocytic leukemia (CLL),[93][94] and Parkinson’s disease.[95] In 2012, Alipogene tiparvovec became the first gene therapy treatment to be approved for clinical use.[96][97] In 2015 a virus was used to insert a healthy gene into the skin cells of a boy suffering from a rare skin disease, epidermolysis bullosa, in order to grow, and then graft healthy skin onto 80 percent of the boy’s body which was affected by the illness.[98] Germline gene therapy would result in any change being inheritable, which has raised concerns within the scientific community.[99][100] In 2015, CRISPR was used to edit the DNA of non-viable human embryos,[101][102] leading scientists of major world academies to called for a moratorium on inheritable human genome edits.[103] There are also concerns that the technology could be used not just for treatment, but for enhancement, modification or alteration of a human beings’ appearance, adaptability, intelligence, character or behavior.[104] The distinction between cure and enhancement can also be difficult to establish.[105]

Researchers are altering the genome of pigs to induce the growth of human organs to be used in transplants. Scientists are creating “gene drives”, changing the genomes of mosquitoes to make them immune to malaria, and then spreading the genetically altered mosquitoes throughout the mosquito population in the hopes of eliminating the disease.[106]

Genetic engineering is an important tool for natural scientists. Genes and other genetic information from a wide range of organisms can be inserted into bacteria for storage and modification, creating genetically modified bacteria in the process. Bacteria are cheap, easy to grow, clonal, multiply quickly, relatively easy to transform and can be stored at -80C almost indefinitely. Once a gene is isolated it can be stored inside the bacteria providing an unlimited supply for research.[107]

Organisms are genetically engineered to discover the functions of certain genes. This could be the effect on the phenotype of the organism, where the gene is expressed or what other genes it interacts with. These experiments generally involve loss of function, gain of function, tracking and expression.

Organisms can have their cells transformed with a gene coding for a useful protein, such as an enzyme, so that they will overexpress the desired protein. Mass quantities of the protein can then be manufactured by growing the transformed organism in bioreactor equipment using industrial fermentation, and then purifying the protein.[111] Some genes do not work well in bacteria, so yeast, insect cells or mammalians cells can also be used.[112] These techniques are used to produce medicines such as insulin, human growth hormone, and vaccines, supplements such as tryptophan, aid in the production of food (chymosin in cheese making) and fuels.[113] Other applications with genetically engineered bacteria could involve making them perform tasks outside their natural cycle, such as making biofuels,[114] cleaning up oil spills, carbon and other toxic waste[115] and detecting arsenic in drinking water.[116] Certain genetically modified microbes can also be used in biomining and bioremediation, due to their ability to extract heavy metals from their environment and incorporate them into compounds that are more easily recoverable.[117]

In materials science, a genetically modified virus has been used in a research laboratory as a scaffold for assembling a more environmentally friendly lithium-ion battery.[118][119] Bacteria have also been engineered to function as sensors by expressing a fluorescent protein under certain environmental conditions.[120]

One of the best-known and controversial applications of genetic engineering is the creation and use of genetically modified crops or genetically modified livestock to produce genetically modified food. Crops have been developed to increase production, increase tolerance to abiotic stresses, alter the composition of the food, or to produce novel products.[122]

The first crops to be realised commercially on a large scale provided protection from insect pests or tolerance to herbicides. Fungal and virus resistant crops have also being developed or are in development.[123][124] This make the insect and weed management of crops easier and can indirectly increase crop yield.[125][126] GM crops that directly improve yield by accelerating growth or making the plant more hardy (by improving salt, cold or drought tolerance) are also under development.[127] In 2016 Salmon have been genetically modified with growth hormones to reach normal adult size much faster.[128]

GMOs have been developed that modify the quality of produce by increasing the nutritional value or providing more industrially useful qualities or quantities.[127] The Amflora potato produces a more industrially useful blend of starches. Soybeans and canola have been genetically modified to produce more healthy oils.[129][130] The first commercialised GM food was a tomato that had delayed ripening, increasing its shelf life.[131]

Plants and animals have been engineered to produce materials they do not normally make. Pharming uses crops and animals as bioreactors to produce vaccines, drug intermediates, or the drugs themselves; the useful product is purified from the harvest and then used in the standard pharmaceutical production process.[132] Cows and goats have been engineered to express drugs and other proteins in their milk, and in 2009 the FDA approved a drug produced in goat milk.[133][134]

Genetic engineering has potential applications in conservation and natural area management. Gene transfer through viral vectors has been proposed as a means of controlling invasive species as well as vaccinating threatened fauna from disease.[135] Transgenic trees have been suggested as a way to confer resistance to pathogens in wild populations.[136] With the increasing risks of maladaptation in organisms as a result of climate change and other perturbations, facilitated adaptation through gene tweaking could be one solution to reducing extinction risks.[137] Applications of genetic engineering in conservation are thus far mostly theoretical and have yet to be put into practice.

Genetic engineering is also being used to create microbial art.[138] Some bacteria have been genetically engineered to create black and white photographs.[139] Novelty items such as lavender-colored carnations,[140] blue roses,[141] and glowing fish[142][143] have also been produced through genetic engineering.

The regulation of genetic engineering concerns the approaches taken by governments to assess and manage the risks associated with the development and release of GMOs. The development of a regulatory framework began in 1975, at Asilomar, California.[144] The Asilomar meeting recommended a set of voluntary guidelines regarding the use of recombinant technology.[145] As the technology improved USA established a committee at the Office of Science and Technology,[146] which assigned regulatory approval of GM plants to the USDA, FDA and EPA.[147] The Cartagena Protocol on Biosafety, an international treaty that governs the transfer, handling, and use of GMOs,[148] was adopted on 29 January 2000.[149] One hundred and fifty-seven countries are members of the Protocol and many use it as a reference point for their own regulations.[150]

The legal and regulatory status of GM foods varies by country, with some nations banning or restricting them, and others permitting them with widely differing degrees of regulation.[151][152][153][154] Some countries allow the import of GM food with authorisation, but either do not allow its cultivation (Russia, Norway, Israel) or have provisions for cultivation, but no GM products are yet produced (Japan, South Korea). Most countries that do not allow for GMO cultivation do permit research.[155] Some of the most marked differences occurring between the USA and Europe. The US policy focuses on the product (not the process), only looks at verifiable scientific risks and uses the concept of substantial equivalence.[156] The European Union by contrast has possibly the most stringent GMO regulations in the world.[157] All GMOs, along with irradiated food, are considered “new food” and subject to extensive, case-by-case, science-based food evaluation by the European Food Safety Authority. The criteria for authorisation fall in four broad categories: “safety,” “freedom of choice,” “labelling,” and “traceability.”[158] The level of regulation in other countries that cultivate GMOs lie in between Europe and the United States.

One of the key issues concerning regulators is whether GM products should be labeled. The European Commission says that mandatory labeling and traceability are needed to allow for informed choice, avoid potential false advertising[169] and facilitate the withdrawal of products if adverse effects on health or the environment are discovered.[170] The American Medical Association[171] and the American Association for the Advancement of Science[172] say that absent scientific evidence of harm even voluntary labeling is misleading and will falsely alarm consumers”. Labeling of GMO products in the marketplace is required in 64 countries.[173] Labeling can be mandatory up to a threshold GM content level (which varies between countries) or voluntary. In Canada and the USA labeling of GM food is voluntary,[174] while in Europe all food (including processed food) or feed which contains greater than 0.9% of approved GMOs must be labelled.[157]

Critics have objected to the use of genetic engineering on several grounds, that include ethical, ecological and economic concerns. Many of these concerns involve GM crops and whether food produced from them is safe, whether it should be labeled and what impact growing them will have on the environment. These controversies have led to litigation, international trade disputes, and protests, and to restrictive regulation of commercial products in some countries.[175]

Accusations that scientists are “playing God” and other religious issues have been ascribed to the technology from the beginning.[176] Other ethical issues raised include the patenting of life,[177] the use of intellectual property rights,[178] the level of labeling on products,[179][180] control of the food supply[181] and the objectivity of the regulatory process.[182] Although doubts have been raised,[183] economically most studies have found growing GM crops to be beneficial to farmers.[184][185][186]

Gene flow between GM crops and compatible plants, along with increased use of selective herbicides, can increase the risk of “superweeds” developing.[187] Other environmental concerns involve potential impacts on non-target organisms, including soil microbes,[188] and an increase in secondary and resistant insect pests.[189][190] Many of the environmental impacts regarding GM crops may take many years to be understood are also evident in conventional agriculture practices.[188][191] With the commercialisation of genetically modified fish there are concerns over what the environmental consequences will be if they escape.[192]

There are three main concerns over the safety of genetically modified food: whether they may provoke an allergic reaction; whether the genes could transfer from the food into human cells; and whether the genes not approved for human consumption could outcross to other crops.[193] There is a scientific consensus[194][195][196][197] that currently available food derived from GM crops poses no greater risk to human health than conventional food,[198][199][200][201][202] but that each GM food needs to be tested on a case-by-case basis before introduction.[203][204][205] Nonetheless, members of the public are much less likely than scientists to perceive GM foods as safe.[206][207][208][209]

The literature about Biodiversity and the GE food/feed consumption has sometimes resulted in animated debate regarding the suitability of the experimental designs, the choice of the statistical methods or the public accessibility of data. Such debate, even if positive and part of the natural process of review by the scientific community, has frequently been distorted by the media and often used politically and inappropriately in anti-GE crops campaigns.

Panchin, Alexander Y.; Tuzhikov, Alexander I. (14 January 2016). “Published GMO studies find no evidence of harm when corrected for multiple comparisons”. Critical Reviews in Biotechnology: 15. doi:10.3109/07388551.2015.1130684. ISSN0738-8551. PMID26767435. Here, we show that a number of articles some of which have strongly and negatively influenced the public opinion on GM crops and even provoked political actions, such as GMO embargo, share common flaws in the statistical evaluation of the data. Having accounted for these flaws, we conclude that the data presented in these articles does not provide any substantial evidence of GMO harm.

The presented articles suggesting possible harm of GMOs received high public attention. However, despite their claims, they actually weaken the evidence for the harm and lack of substantial equivalency of studied GMOs. We emphasize that with over 1783 published articles on GMOs over the last 10 years it is expected that some of them should have reported undesired differences between GMOs and conventional crops even if no such differences exist in reality. and

Yang, Y.T.; Chen, B. (2016). “Governing GMOs in the USA: science, law and public health”. Journal of the Science of Food and Agriculture. 96: 18511855. doi:10.1002/jsfa.7523. PMID26536836. It is therefore not surprising that efforts to require labeling and to ban GMOs have been a growing political issue in the USA (citing Domingo and Bordonaba, 2011).

Overall, a broad scientific consensus holds that currently marketed GM food poses no greater risk than conventional food… Major national and international science and medical associations have stated that no adverse human health effects related to GMO food have been reported or substantiated in peer-reviewed literature to date.

Despite various concerns, today, the American Association for the Advancement of Science, the World Health Organization, and many independent international science organizations agree that GMOs are just as safe as other foods. Compared with conventional breeding techniques, genetic engineering is far more precise and, in most cases, less likely to create an unexpected outcome.

GM foods currently available on the international market have passed safety assessments and are not likely to present risks for human health. In addition, no effects on human health have been shown as a result of the consumption of such foods by the general population in the countries where they have been approved. Continuous application of safety assessments based on the Codex Alimentarius principles and, where appropriate, adequate post market monitoring, should form the basis for ensuring the safety of GM foods.

“Genetically modified foods and health: a second interim statement” (PDF). British Medical Association. March 2004. Retrieved 21 March 2016. In our view, the potential for GM foods to cause harmful health effects is very small and many of the concerns expressed apply with equal vigour to conventionally derived foods. However, safety concerns cannot, as yet, be dismissed completely on the basis of information currently available.

When seeking to optimise the balance between benefits and risks, it is prudent to err on the side of caution and, above all, learn from accumulating knowledge and experience. Any new technology such as genetic modification must be examined for possible benefits and risks to human health and the environment. As with all novel foods, safety assessments in relation to GM foods must be made on a case-by-case basis.

Members of the GM jury project were briefed on various aspects of genetic modification by a diverse group of acknowledged experts in the relevant subjects. The GM jury reached the conclusion that the sale of GM foods currently available should be halted and the moratorium on commercial growth of GM crops should be continued. These conclusions were based on the precautionary principle and lack of evidence of any benefit. The Jury expressed concern over the impact of GM crops on farming, the environment, food safety and other potential health effects.

The Royal Society review (2002) concluded that the risks to human health associated with the use of specific viral DNA sequences in GM plants are negligible, and while calling for caution in the introduction of potential allergens into food crops, stressed the absence of evidence that commercially available GM foods cause clinical allergic manifestations. The BMA shares the view that that there is no robust evidence to prove that GM foods are unsafe but we endorse the call for further research and surveillance to provide convincing evidence of safety and benefit.

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Genetic engineering – Wikipedia

Kraken Exchange Review: Facts to Know Before Buying Any Cryptocurrency

Kraken Exchange Review
Kraken is one of the most popular exchanges where users can buy and sell cryptocurrencies. It is arguably the largest Bitcoin exchange, based on liquidity. Kraken was also the first Bitcoin exchange to have its trading price and volume displayed in the “Bloomberg Terminal”.

Having established its reputation in the cryptocurrency world, Kraken is the first choice of many international cryptocurrency traders.

The following table is a Kraken exchange review with all the basic info you need.
Kraken.

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Kraken Exchange Review: Facts to Know Before Buying Any Cryptocurrency

Crypto Crash 2018: Ripple and Ethereum Still Have Huge Potential

Crypto Crash 2018: A Correction or Something More Ominous?
The sky is falling in the cryptocurrency world, as the prices are in the grips of a painful sell-off. Given the parabolic nature of the rise, investors continue to grapple with the bubble theory.

In a matter of days, the entire basket of cryptocurrencies has shed half of its market capitalization. The carnage has been widespread, and none of the major cryptocurrencies have been spared.

Bearish articles are making the rounds, and cryptocurrencies such as Ripple (XRP) and.

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Crypto Crash 2018: Ripple and Ethereum Still Have Huge Potential

Ethereum Crash 2018: Why ETH Can Easily Survive the Crypto Carnage

Making Sense of the Cryptocurrency Crash 2018
How eerie is it that exactly 10 days ago, I was sitting in the exact same spot around the exact same time and writing about the possibility of an Ethereum crash? 10 days later, it has occurred and here I am, reiterating my stance. There’s little that has changed in my Ethereum price forecast for 2018 and I can tell you why.

As of now, a cryptocurrency carnage of epic proportions is underway. There’s blood splattered everywhere. Red digits are flashing on computer screens, hearts are sinking,.

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Ethereum Crash 2018: Why ETH Can Easily Survive the Crypto Carnage

Ripple Price Prediction: Big Business Ensures Higher XRP Prices in 2018

Ripple News Update
Cryptocurrencies passed through all stages of Dante’s Inferno this week, but that doesn’t mean investors are confined to hell in perpetuity. There is a way out, and its name is Big Business.

Or to put it in crypto terms, “enterprise use-cases of blockchain technology may expedite token adoption” by “leveraging the power of existing institutions.” (My god, this industry needs better language.)

What am I talking about?

Let me explain…

When the market crashes, investors believe that cryptocurrencies are failing. This is true in some cases and horribly untrue in others.
Ripple (XRP) Price Chart.

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Ripple Price Prediction: Big Business Ensures Higher XRP Prices in 2018

Litecoin Price Prediction: Upcoming Litecoin Upgrade To Make it Even Cheaper Than Bitcoin

Daily Litecoin News Update
It’s a quiet day in the cryptocurrency world. The storm has settled and the sun is out. Investors are finally out of choppy waters and trading with more peace of mind. Top cryptos, including Litecoin are trading in the green. At this point another piece of good news may serve as the icing on the cake that Litecoin investors may have been longing to taste.

Litecoin founder Charlie Lee updates from the headquarters that Litecoin’s next upgrade is on its way. As promised, the developers will be cutting down transaction fees to further make LTC transactions cheaper for users.

Later, he also updates that Litecoin, like Bitcoin, would be integrating.

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Litecoin Price Prediction: Upcoming Litecoin Upgrade To Make it Even Cheaper Than Bitcoin

Ethereum Price Forecast: DApps Might Send ETH Price Soaring in 2018

Ethereum Price Forecast
Given the recent rollercoaster in Ethereum prices, it’s time to consider what makes ETH more valuable than the 1,400 other cryptocurrencies on the market. I call this theory “trickle-down cryptonomics”—others call it “fat protocol theory.”

What am I talking about?

To put it simply, Ethereum’s greatest strength is that it serves as a launching pad for other cryptos. Namely, cryptos that operate as part of decentralized applications (DApps).

DApps are identical to regular apps, except for one small difference—they.

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Ethereum Price Forecast: DApps Might Send ETH Price Soaring in 2018

Ripple Price Forecast: Korbit, IMF & Other Causes of XRP Price Crash

Ripple News Update
At the end of last week, it looked like cryptocurrencies would outrun the storm of government regulations bearing down on them. But that analysis was all wrong—it’s now clear that we were sitting in the eye of the storm.

However, the momentary calm wasn’t so bad. It led to a short-lived rally in Ripple prices, which in turn revived some enthusiasm on Reddit and other discussion boards.

Then a barrage of bad news broke over the weekend. Not only did this snap the optimism, but it reminded us that governments are getting.

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Ripple Price Forecast: Korbit, IMF & Other Causes of XRP Price Crash