Scientific Sessions Track 1: Molecular Medicine
Molecular medicine is a broad field which deals with the development of diseases at a molecular level and identifies fundamental molecular and genetic errors of disease and to develop molecular interventions to correct them. Molecular structures and mechanisms are described by Physical, chemical, biological, bioinformatics and medical techniques. Disease pathogenesis at the molecular or physiological level may lead to the design of specific tools for disease diagnosis, treatment, or prevention.
By understanding the genes, proteins, and other cellular molecules work molecular medicine develops ways to diagnose and treat disease. Molecular Medicine develops knowledge and skills in cellular and molecular biology.
Molecular diagnostics is a collection of techniques used to analyse an individual’s genetic code and to identify biological markers in the genome and proteome. Molecular diagnostics apply molecular biology to see how cell express their genes to medical testing. For any successful application of gene therapy or biologic response modifiers, molecular diagnostics offers a great tool. Molecular diagnostics now provides most laboratory tests in infectious diseases, genetics, and an increasing number in oncology. Molecular diagnostics analyse a person’s health at a molecular level by detecting specific sequences in deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) that may be related to disease
Molecular genetics employs methods of both molecular biology and genetics to study the structure, function and interactions among genes at a molecular level.
The study of chromosomes and gene expression of an organism can give an accurate and deep understanding of heredity, genetic variation, and mutations. Molecular Genetics and Genomics cover all areas on the latest research innovations, population genetics, gene function and expression and molecular genetics. Molecular genetics is concerned with the study of your favourite gene, genomics is concerned with studying all the genes. Molecular genomics is a critical component of the expanding database linking alterations of DNA and RNA with the disease, disease prognosis and therapeutic response.
Molecular oncology refers to the chemistry of cancer and tumours at the molecular scale and their development and application on molecularly targeted therapies.
Molecular Oncology studies especially the genetic alterations and their implications. Molecular Oncology focuses on new discoveries, approaches, as well as technical developments in basic, clinical and discovery-driven cancer research. It mainly focuses on advances in the understanding of disease processes leading to human tumour development. Molecular Oncology establishes novel concepts of clear clinical significance in diagnosis, prognosis and prevention strategies.
A biomarker is used as an indicator of the biological state. In routine clinical use Oncology biomarkers actually, make their way. A biological marker points to the presence of a disease, a physiological change, response to treatment, or a psychological condition.
Molecular biomarkers are used for various purposes including disease diagnosis and prognosis and assessment of treatment response. Over the last decade, there has been a significant increase in the number of drug labels containing information on molecular biomarkers. In most of the chronic diseases, biomarkers can confirm a difficult diagnosis or even make it possible in the first place.
Molecular biology is the study of biological activity between biomolecules in the various systems of a cell. It also includes the interactions between DNA, RNA, proteins and their biosynthesis as well as the regulation of these interactions.
Cellular and Molecular Biology majorly study the processes that occur within and between the body’s cells. This includes genes, the way cells carry nutrients throughout the body, and how diseases attack healthy cells. The process of replication, transcription and translation of the genetic material are studied under Molecular biology. Cellular biology study cells, including their function, systems, structure and interactions with living organisms. These typically work in medical fields and are often focused on the treatment of disease.
Molecular pathology is the study of molecules within organs, tissues or bodily fluids. Molecular pathology is commonly used in the diagnosis of bone, soft tissue tumours, cancer and infectious diseases. The purpose of molecular pathology is to understand the mechanisms of disease by identifying molecular and pathway alterations. It is considered the heart of modern diagnostics and translational research. Molecular pathology studies and diagnose disease through the examination of genetic and molecular abnormalities. Molecular pathology and biomarkers are used to study molecular and genomic abnormalities in tissues for diagnostic and prognostic purposes. Molecular diagnosis is useful and sometimes necessary as an adjunct for diagnosis especially in morphologically or clinically unusual lesions.
Living things all are alike at the cellular and molecular level. The fundamental similarities between living organisms are explained by evolutionary theory. Major topics in molecular evolution concern the rates and impacts of single nucleotide changes, origins of new genes, the evolution of development, and ways that evolutionary forces influence genomic and phenotypic changes. Some of the key advances are quantitative estimates of both the diversity in populations and of evolutionary relationships, as well as improvements in theoretical understanding. There is an improved understanding of the function of proteins and much better models of the common patterns of development.
Advances in cell and molecular biology studies have revolutionized the diagnosis and treatment of many different diseases. It is considered as a modern Biotechnology concerned with understanding the Genetic Diagnosis, Molecular Diagnosis, Molecular Forensics.
People at the present day are facing serious global challenges in healthcare from emerging and re-emerging diseases. The availability of new sequencing methods, microarrays, microfluidics, biosensors, and biomarker assays has made a shift toward developing diagnostic platforms, which stimulates growth in the field regarding diagnosis, prognosis, and treatment, leading to improved outcomes and greater cost savings.
Much research is being done in foetal whole exome sequencing and is beginning to play a large role in miscarriage testing. With all this research and screening, clinicians and genetic counsellors need to keep abreast of these changes and guidelines in order to effectively care for patients.
The genetic cause of foetal abnormalities detected on ultrasound imaging and in high-risk families can be significantly identified and improved in Foetal diagnostic exome sequencing. Testing based on isolation of foetal cells from maternal blood would provide an attractive alternative to testing of cell-free DNA. An updated implementation of these different approaches will make lively discussion and insight into this field and is headed ways for researchers, test providers, clinicians and clinics to take these developments into consideration.
Point-of-care testing is medical diagnostic testing at the time and place of patient care. In Recent years there are tremendous advances in POCD due to innovations lab-on-a-chip technologies, and complementary technologies. Critical advances in POCD provides directions for future research. Point-of-care allows physicians and medical staff to accurately achieve real-time, lab-quality diagnostic results within minutes rather than hours. The global Point of Care diagnostic tests renders immediate results providing improved patient care in rural areas too. This factor has significantly impacted the market growth.
Clinical diagnostics is defined as diagnosis and treatment of human disease. Clinical diagnostics for a disease can be done by patient’s complaints based on signs, symptoms and medical history rather than on laboratory examination or medical imaging. Clinical diagnostics is considered as an ever-changing field of medicine and research. In recent years Clinical diagnostics has become more exciting as advances in new techniques aid in fulfilling the potential of personalized medicine. Clinical research determines the safety and effectiveness of medications, devices, diagnostic products and treatments.
A monoclonal antibody (mAb) is originally produced by a single B-cell. Biosimilars are a lot complicated than small-molecule medicine and generics. In the past few years, monoclonal antibody drugs have dominated the world’s largest biopharmaceutical drug sales, and in the coming years, monoclonal antibody drugs will continue to be the main force. Considering the huge profit margins and potential market, the monoclonal antibody-based therapeutics is the hot territory many pharmaceutical companies chases. This session will summarize the market in terms of therapeutic applications, type, and structure of mAbs, dominant companies, manufacturing locations, and emerging markets. These requirements would lead to greater development in the process and tighter quality controls during the production of biosimilar mAbs.
Infectious diseases are caused by pathogenic organisms such as viruses, bacteria, or fungus. Normally harmless but under certain conditions, they can be fatal and can cause death too. They can be spread from one person to another directly or indirectly. Infectious diseases are caused by infection-causing organisms that use the human body for surviving, reproducing and colonizing. These organisms are known as pathogens.
Antibiotics are used to treat bacterial infections;
Antiviral agents treat viral infections;
Antifungal agents treat fungal infections.
Next-generation sequencing (NGS) has revolutionised the study of genomics and molecular biology by allowing us to sequence DNA and RNA much more quickly and cheaply than the previously used Sanger sequencing. Next Generation Sequencing (NGS) relies on capillary electrophoresis. NGS although with shorter read lengths and less accuracy reduces the time that genome sequencing projects took with Sanger methods.
Thousands to millions of DNA molecules can be sequenced simultaneously by using Powerful Next Generation Sequencing (NGS) platform. By offering a high throughput option NGS is revolutionizing in fields such as personalized medicine, genetic diseases, and clinical diagnostics.
Immunogenicity is the ability of a particular substance induce a humoral and/or cell-mediated immune responses. An immune response can be potentially elicited by administering any substance into the human body.
Products which increase the potential of anti-drug antibodies include :
Therapeutic antibodies, enzyme therapies, peptides and combination products.
An immune response may also impact a drugs safety and efficacy. Assays should be designed in such a way that they provide sufficient sensitivity and are free from potential risks to the target patient population. By designing assays with these factors, it is possible to gather data about the strength and type of immune response that a drug may produce in humans.
Metagenomics is the study of genetic material recovered from environmental samples. Metagenomics could be an asset of analysis techniques comprising several connected approaches and ways. We tend to anticipate that metagenomics can complement and stimulate analysis on people and their genomes.
Metagenomics represents a brand-new approach in exceedingly genomic analysis. Metagenomic libraries can be screened for novel physiological, metabolic, and genetic options. Though long and labour-intensive, metagenomics is the most powerful environmental approach that provides prospects to get novel genes and novel biomolecules through the expression of genes from an uncultivated and unknown bacterium in a recipient host cell. Metagenomic information ought to contain DNA sequences for all the genes within the microorganism community
Cell therapies and regenerative medication boost the health of patients by repairing, replacing, or by creating broken cells within the body. Some elements of our bodies will repair themselves quite well when injured, while others dont repair in any respect. We cant develop an entire leg or arm; however, some animals will develop or regenerate whole body elements. Stem cells (SC) offer totally different. Despite the promise of embryonic stem cells, in several cases, adult or perhaps vertebrate stem cells give a lot of fascinating approach for clinical applications. Clinical applications in regenerative medication have increased tremendously throughout the last ten years. Regenerative medication revolutionizes the method to improve the health and quality of life by restoring, maintaining or enhancing tissue and functions of organs.
Clinical chemistry is usually involved with analysis of bodily fluids for diagnostic and therapeutic functions. It’s an applied style of organic chemistry. There are currently several blood tests and clinical tests with intensive diagnostic capabilities. These are performed on any bodily fluid or plasma. The foremost common specimens tested in clinical chemistry are blood and Serum. Many various tests exist to check glucose, electrolytes, enzymes, hormones, lipids (fats), and proteins. By running tests on these samples, physicians will confirm patient conditions and potential diseases, and recommend a counselled treatment up. Clinical chemistry procedures create precise diagnoses, offer effective treatment choices and monitor a patients response to treatment.
Pharmacogenomics is the study of the gene effect on a persons response to medication. This comparatively new field combines pharmacological medicine and genetics to develop effective, safe medications and doses that may be tailored to a persons genetic makeup. Several medications presently accessible do not work a similar manner for everybody. Adverse drug reactions are a unit of big trouble for hospitalizations. With the data gained from the HGP, researchers are learning variations in genes have an effect on the bodys response to medications.
The field of pharmacogenomics continues to be in its infancy. Its use is presently quite restricted, however new approaches are in clinical trials. In future, pharmacogenomics can permit the tailored medication to treat health issues, as well as disorders, Alzheimer sickness, cancer, HIV/AIDS, and asthma.
DNA sequencing is the method of sequencing the base pairs of a DNA (As, Ts, Cs, and Gs). Sequencing a whole organisms DNA is a huge task. It needs breaking the DNA into several smaller items, sequencing the items, and collection of these sequences into one long “consensus.”
These bases give the information on genotype and also the phenotype. Nucleotides aren’t the sole determinants of phenotypes but are essential to their information. Every individual and organism feature a specific ester base sequence. DNA sequencing additionally underpins pharmacogenomics. This can be a comparatively new field that is leading to an individualized medication. Over a hundred and forty medication approved by the FDA currently by pharmacogenomic data in their labelling.
Translational medicine is defined as an interdisciplinary branch of the biomedical field. By using a highly collaborative approach Translational medicine is growing in biomedical research discipline and aims to expedite the discovery of new diagnostic tools and treatments. Within public health, translational medicine is focused on ensuring proven strategies for disease treatment and prevention. Translational medicine aims to improve human health and longevity by determining the relevance to human disease of novel discoveries in the biological sciences. Translational medicine is enhancing the efficiency of biomedical discovery and application. There are many compelling reasons to find cost-effective solutions to health care delivery.
Integrative Molecular Medicine covers novel findings in molecular, biological, and biomedicine research. The broad spectrum of Integrative Molecular Medicine includes rare and common disorders from diagnosis to treatment.
Molecular drugs strive to know traditional body functioning and illness pathological process at the molecular level which can enable researchers and physician-scientists to use that information within the style of specific molecular tools for illness identification, treatment, and prognosis. Integrative Molecular drugs (imMed) offers a scientific setting, which mixes basic and clinical analysis and offers a broad vary of advanced opportunities.
Medical doctors, patients, and health care providers consider the prevention of genetic diseases as an essential tool to improve the general health status of the population and the proportion of people suffering from genetics and genomics disease will increase by 65.2% by 2025. The top institutions researching in the related studies have been funded with 100 Billion Dollar worldwide. According to recent statistics, genetic diseases worldwide will double between 2012 and 2025. The market value of Molecular Medicine is $24 billion in 2015 and is expected to reach more than $100 billion by 2025.
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In 2015, the global molecular diagnostics market size was valued at USD 6,451.5 million and is anticipated to grow. In 2018, infectious diseases account for the largest share of the global molecular diagnostics market. Greater accuracy, portability, cost-effectiveness and Technological advancements enable molecular diagnostics to significantly drive the market.
Over the forecast period, the rising prevalence of infectious diseases and hospital-acquired infections are expected to drive market growth. Rise in cardiovascular, neurological, and genetic disorders is also expected to fuel market growth. Governments and different organizations Increase in funding for clinical studies in the molecular diagnosis space boost the market growth.
The hospitals and academic laboratories segment are expected to account for the largest share of the market in 2018.
The growth of the UAE diagnostic market can be attributed to the high prevalence of chronic and infectious diseases. WHO estimates of all deaths worldwide Chronic diseases account for approximately 60 %. Chronic diseases such as cancer, cardiovascular diseases, diabetes, and chronic respiratory diseases are responsible for 12%, 40%, 5%, and 5% of mortality in the United Arab Emirates. There has been a paradigm shift from traditional diagnostics to a new generation diagnostic, that works at the gene level. The inclusion of Advanced technologies such as genetic testing, molecular diagnostics, polymerase chain reaction (PCR), and next-generation sequencing (NGS) made it possible.
The major market players in the UAE molecular diagnostics market are :
The competition among manufacturers is increasing, with the increasing number of companies.
ME Conferenceshosted10thInternational Conference on Genomics & Molecular BiologyduringMay 21-23, 2018atBarcelona, Spainbased on the theme Advanced Approaches In Genomics and Molecular Biology.
Active participation and generous response was received from the Organizing Committee Members, scientists, researchers, as well as experts from Non-government organizations, and students from diverse groups who made this conference as one of the most successful and productive events in 2018 fromME Conferences.
The conference was marked with several workshops, multiple sessions, Keynote presentations, panel discussions and Poster sessions. We received active participation from scientists, young and brilliant researchers, business delegates and talented student communities representing more than 35 countries, who have driven this event into the path of success.
The conference was initiated with a warm welcome note by Honorable guests and the Keynote forum.The proceedings went through interactive sessions and panel discussions headed byhonorable ModeratorDr.Laila Alves Nahum, Ren Rachou Research Center, Brazilfor the conference.
The conference proceedings were carried out through various Scientific-sessions and plenary lectures, of which the following Speakers were highlighted asKeynote speakers:
Single point mutation of a gene creates mirror-image animals in freshwater gastropod:Reiko Kuroda, Tokyo University of Science, Japan
Evolutionary genomics to improve functional prediction of parasite genes and proteins:Laila Alves Nahum, Ren Rachou Research Center, Brazil
Big data in noncoding RNA and precision medicine:Runsheng Chen, Institute of Biophysics – CAS, China
Treatment of landfi ll leachate via advanced biological treatment technology:Ling Tau Chuan, University of Malaya, Malaysia
Biophysical signaling, systems biology and carcinogenesis:Sarah S Knox, West Virginia University School of Public Health USA
How does nucleoid complexity affect cell dimensions during the division process in bacillary bacteria: Arieh Zaritsky, Ben-Gurion University of the Negev, Israel
ME Conferenceshas taken the privilege of felicitating Genomics-2018 Organizing Committee, Keynote Speakers who supported for the success of this event.ME Conferences, on behalf of the Organizing Committee, congratulates the Best Poster awardees for their outstanding performance in the field of Genomics & Pharmacogenomics and appreciates all the participants who put their efforts in poster presentations and sincerely wishes them success in future endeavors.
Poster Judging was done byDr.Arieh Zaritsky, Ben-Gurion University of the Negev, Israel
We are also obliged to various delegate experts, company representatives and other eminent personalities who supported the conference by facilitating active discussion forums. We sincerely thank theOrganizing Committee Membersfor their gracious presence, support, and assistance towards the success of Genomics-2018.
With the unique feedback from the conference,ME Conferenceswould like to announce the commencement of the “4th International Conference on Molecular Medicine and Diagnostics”duringJuly 15-16, 2019 in Abu Dhabi, UAE.
For More details visit:https://molecularmedicine.conferenceseries.com/
Molecular Medicine Conference 2019 | Molecular Diagnostics …