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Applications of nanotechnology in the automotive industry – Geospatial World

Nanotechnology the creation and use of devices and machines on almost an atomic level is likely to be the driving force behind the next great revolution to benefit humankind. The actual definition of nanotechnology can be quite broad, generally, in scientific and engineering terms, nanotechnology is the manipulation of matter with at least one dimension sized from 1 to 100 nanometers (0.000000001 m). That really does put it on an atomic scale, though the products that can be constructed in this way may be a little larger and can range from microscopic to anything under a millimetre.

While this kind of technology will have applications in many fields, there are likely to be huge advantages in the field of cars and motoring and in the near future, nanotechnology is likely to have a massive impact on the world of driving and vehicles.

It is a fact that nanotechnology can impact so many areas of motoring makes it one of the most important up and coming technologies, and it has attracted the attention of a great number of researchers. This has led to a growing number of breakthroughs in the field, and even more possibilities for this exciting and highly flexible area of science to push different fields of motoring forward. But where is nanotechnology having the greatest influence in car manufacture?

We ask a lot of our internal combustion engines in terms of both increased performance and decreased size and weight. Those two elements together would usually mean disaster for a high-performance engine, but nano-engineering has allowed us to do both, and safely. Engine blocks, which house the fundamental moving parts of the mechanism, were traditionally made of cast iron, because it was the only practical material that could resist the high temperatures and pressures that were produced in the heart of an engine. But engineers soon found that certain grades of aluminium which weighs around a third that of cast iron were found to be suitable too.

But now, engineers have learned how to manipulate aluminiums on an atomic level nanoengineering to create materials that are both stronger while being more lightweight than even the current batch of strong aluminium alloys. This makes them even more fuel efficient while having an increased durability, even in the increasingly hostile conditions found in modern engines. It is a fact that an internal combustion engine performs better and is more efficient at higher temperatures, so this is always a goal for engine designers. We are now also experiencing methods of placing ultra-thin layers of engineering ceramics on metal substrates, creating a surface that is capable of withstanding higher temperatures and wear situations.

Manipulation of either the fundamental structure of the engine block material, or the surface architecture or both, even gives designers far greater scope in heat dissertation, wear characteristics, and strength at elevated temperatures.

We have also seen advances in motor oils, particularly in respect to their ability to withstand the punishing environments of modern engines. Nano-manipulation has created a new breed of oils that are able to cling to internal surfaces for longer, meaning that it is in the right place when the engine starts, so that it offers protection right from the start. Nanotechnology oils are also able to put up with much greater use as the tolerances between engine parts decreases and they operate closer together.

Fuel efficiency, whether the car is petrol, diesel, or electric, is a function of its weight, and even quite small reductions in weight can lead to increase attained mileage significantly. One of the best ways to cut the weight of a vehicle is to use lightweight materials for the structural chassis parts and the exterior, and this is another area where nano-manipulation of materials can create stronger, more lightweight, panels and chassis that are stronger than the ones that they have replaced. Nanotechnology is also responsible for the creation of plastic panels that are able to self-repair and reform themselves following damage.

As the next generation of electric vehicles become common on our streets, engineers and researchers are looking at how to lengthen battery life while increasing performance. This has led to the development of lithium-silicon batteries which promise to boost performance and increase longevity. The latest developments in this fast-moving include silicon nanowires that expand and contract as they absorb and shed lithium ions, and tiny nano-structures with carbon shells protecting lithium-rich silicon cores. This combination allows for more efficient energy transfer, meaning that less energy is lost to the environment as heat and more is supplied to the system.

Nanotechnology is also improving fuel cells the clean alternative technology to hydrocarbon fuels. In these, hydrogen is passed over a catalyst to produce hydrogen ions which then go on to reattached to oxygen and result in energy production. The catalysts are increasingly variations of platinum nano-structures to maximise the surface area and harvest the greatest number of hydrogen ions, thereby maximising energy production too.

Nano-sized layers of inorganic filters are increasingly being applied to the vulnerable surfaces of car bodies, to help protect them from harsh environments, and self-repair to an increasing extent. The smart particles can also help repel dirt and grime, keeping your car looking cleaner, while new developments in orientable surface particles mean that we may soon be able to change the outer colour of our cars by adjusting small electrical charges to them.

Interiors. The use of specialist nanotechnology fabrics is helping to keep the interiors of our cars looking fresh and clean, but also repellent to bacterial affects, creating soft, good looking and completely safe interiors. Once again, developments are being made that will allow the colour of the interior to be changes by reorienting the nano-particles of the material, so that the user can choose any combination of colour that they like, while still having excellent antibacterial properties.

Nanotechnology in cars is becoming big business, and as we find new ways to manipulate materials on an atomic scale, so new applications arise. This will lead to cleaner, quieter, more pleasant cars in the future, and that can only be a good thing.

Note: This is a guest blog by Giles Kirkland, an automotive industry writer and researcher.

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Applications of nanotechnology in the automotive industry - Geospatial World

Precision NanoSystems Announces Partnership with Fujifilm for the Development and GMP Manufacturing of Nanoparticle Based Therapeutics – Yahoo Finance

VANCOUVER, March 25, 2020 /PRNewswire/ --Precision Nanosystems, Inc. (PNI), a global leader in enabling transformative nanomedicinesannounced today that the companyentered into a license agreement with FUJIFILM Corporationto adopt PNI's NanoAssemblr technology and complete suite of instruments for Fujifilm'sstate-of-the-art manufacturing facility, compatible with GMP regulations of US, Europe and Japan.

As part of this agreement, Fujifilm has the rights to offer contract manufacturing services using PNI's proprietary technology andalso use PNI technology to develop and commercialize its internal therapeutic drug products. PNI and Fujifilm will work together to combine and democratize the scalable manufacturing of gene therapy and small-molecule based nanomedicines using Fujifilm's and PNI's proprietary technologies.

PNI's NanoAssemblr technology is powered by the disruptive NxGen microfluidics mixing technology designed exclusively for scalable nanomedicine development while maintaining precise control and reproducibility. The NanoAssemblr platform is comprised of the Spark, Ignite, Blaze and GMP Systems that together offer a flexible solution for accelerated, cost-effective development and scalable manufacture of high-quality gene therapy, small molecule and protein-based nanomedicine products.

James Taylor, Co-Founder and CEO of PNI said, "We are thrilled to work with Fujifilm to enable our technology in support of clinical clients as they progress their therapeutic programs from the laboratory to the clinic and commercial. Fujifilm's R&D teams will combinethe PNI platform andtheir proprietary Drug Delivery Systems technologies and we look forward to the seamless scaling up and manufacturing of innovative medicines to impact human well-being."

Nanomedicinesis one of the focus areas of Fujifilm, tapping into itsadvanced technologies such as nano-technology, process engineering technology and analysis technology. "We are excited to work with PNI to bring on board the NanoAssemblr suite of products and cutting-edge nanomedicines manufacturing technology," said Junji Okada, Senior Vice President, General Manager of Pharmaceutical products division, FUJIFILM Corporation. "Tapping into Fujifilm's state of the art technology, expertise and thefacility for the provision of pre-clinical and GMP manufacturing services, we are committed to creating innovative and high-value pharmaceutical productsnot only through internal development but also by providing high quality liposomal formulations to our partner companies."

About Precision NanoSystems Inc.

Precision NanoSystems Inc. (PNI) proprietary NanoAssemblr Platform enables the rapid, reproducible, and scalable manufacture of next generation nanoparticle formulations for the targeted delivery of therapeutic and diagnostic agents to cells and tissues in the body. PNI provides instruments, reagents and services to life sciences researchers, including pharmaceutical companies, and builds strategic collaborations to revolutionize healthcare through nanotechnology. For more information, visit http://www.precisionnanosystems.com.

About Fujifilm CorporationFUJIFILM Corporation, Tokyo, Japan is one of the major operating companies of FUJIFILM Holdings Corporation. The company brings cutting edge solutions to a broad range of global industries by leveraging its depth of knowledge and fundamental technologies developed in its relentless pursuit of innovation. Its proprietary core technologies contribute to the various fields including healthcare, graphic systems, highly functional materials, optical devices, digital imaging and document products. These products and services are based on its extensive portfolio of chemical, mechanical, optical, electronic and imaging technologies. For the year ended March 31, 2019, the company had global revenues of $22 billion, at an exchange rate of 111 yen to the dollar. Fujifilm is committed to responsible environmental stewardship and good corporate citizenship. For more information, please visit: http://www.fujifilmholdings.com.

Jane Alleva, Global Marketing Manager, Precision NanoSystems, Phone: 1 888 618 0031, ext 140, mobile 1 778 877 5473

SOURCE Precision Nanosystems

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Precision NanoSystems Announces Partnership with Fujifilm for the Development and GMP Manufacturing of Nanoparticle Based Therapeutics - Yahoo Finance

Work with 3D printing? Here’s your invitation to help fight Covid-19 – Aircraft Interiors International

Nanofabrica, a manufacturer of 3D printers for precision engineering, is inviting researchers, doctors and manufacturers to apply additive manufacturing techniques to develop medical devices and solutions to help in the fight against Covid-19.

The company is hosting a virtual roundtable on Wednesday, 25 March, at 16:00 GMT+2 and invites all interested parties to join a brainstorming session on how the companys manufacturing capabilities (3D printing with 1 micron resolution over cm sized volume) can be used to develop equipment and supplies needed to fight Covid-19.Possible applications include smart filters for microfluidic chips, anti-bacterial surfaces, complex and precise structures and soft moulds for rapid injection-molding.

Link to event:https://zoom.us/j/324801539

If you are unable to make it for the virtual session, please send an email with all relevant questions and details totovit@nano-fabrica.comand Nanofabricas teamwill reply as soon as possible.

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Work with 3D printing? Here's your invitation to help fight Covid-19 - Aircraft Interiors International

Virtual Medical Device Meetings You Need to Know About – Medical Device and Diagnostics Industry

3D-printing company hosts virtual roundtable Wednesday

Nanofabrica, a Tel Aviv, Israel-based manufacturer of 3D printers for precision engineering, will host a virtual roundtable for researchers, doctors, and manufacturers to harness the companies manufacturing capabilities to develop medical devices and solutions related to the coronavirus (COVID-19) pandemic. The roundtable is scheduled for 4 p.m. GMT+2 (10 a.m. Eastern Time) Wednesday via Zoom. Professionals unable to join the virtual session are invited to email relevant questions and details to [emailprotected].Click here for the meeting link.

FDA hosts virtual town hall for clinical laboratories

FDA will host a virtual town hall for clinical laboratories and commercial manufacturers that are developing or have developed diagnostic tests for COVID-19. The event will be from 3 - 4 p.m. Eastern Time.The purpose of this town hall is toanswer technical questions about the development and validation of tests for the virus and FDAs updated policy on COVID-19 diagnostics issued on March 16. The agency alsoplans to hold virtual town halls for clinical laboratories and commercial manufacturers every Wednesday in April from 3 4p.m. Eastern Time.

Call for survey participantsfor online roundtable

LNS Research, a Cambridge, MA-based firm, is asking professionals across industries to take a brief survey about the strategies companies are taking to sustain critical operations during the COVID-19 pandemic. The survey results will be shared during an online roundtable scheduled for 11 a.m. ET. The goal of the event is to enable organizational leaders to share strategies in responding to the crisis, best practices, and how to prepare for the new normal. Register for the event here.

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Virtual Medical Device Meetings You Need to Know About - Medical Device and Diagnostics Industry

Kanazawa University Research: Insights into the Diagnosis and Treatment of Brain Cancer in Children – PR Newswire UK

KANAZAWA, Japan, March 25, 2020 /PRNewswire/ -- In a recent study published in Autophagy, researchers at Kanazawa University show how abnormalities in a gene called TPR can lead to pediatric brain cancer.

Ependymoma is a rare form of brain cancer that implicates children and is often tricky to diagnose. Since effective treatment options can be initiated only after a well-formed diagnosis, there is a dire need among the medical community to identify markers for ependymoma, which in turn, will help oncologists tailor therapy better. Richard Wong's and Mitsutoshi Nakada's team at Kanazawa University has now shown how one gene closely linked to ependymoma can help with not just diagnosis, but also treatment options for the condition.

A gene known as TPR shows an elevated presence in 38% of ependymoma cases. Thus, the team first sought out to investigate how an increase in the TPR gene correlated to the development of cancer cells. Each gene present in a cell contains a code for the creation of a specific protein. The TPR gene contains the code for an eponymous protein. Therefore, cancer samples from patients were assessed for the levels of TPR protein. As expected, levels of TPR were abnormally high in these tumor tissues.

The researchers then moved on to investigate whether these abnormal TPR levels could lead to cancer progression. For this purpose, mice were implanted with human ependymoma cancer tissue into their brains. The TPR gene was then deleted in these tissues so that the mice were unable to create the TPR protein. When the tumor tissues were subsequently analyzed, a reduction of cancer growth was seen. The TPR gene was thus vital for the growth of ependymoma tumors.

Deletion of the TPR protein is known to induce a process called autophagy within cells. Autophagy is initiated when a cell is under undue stress and results in the death of damaged cells. The patient tumor samples, with their high levels of TPR protein, showed little or no presence of autophagy. However, autophagy was remarkably high in the mice with TPR depletion. Ependymoma cells were thus spared of autophagic death due to the increased presence of TPR. These damaged cells continued to grow by circumventing the biological systems set up to keep them in check. The high TPR levels were also accompanied by an increase in HSF-1 and MTOR, molecules which are responsible for cell growth and survival.

Finally, the possibility of lowering TPR levels therapeutically to control the cancer was assessed. The mice were given a drug called rapamycin, which inhibits MTOR. The treatment not only led to decreased TPR levels, but also shrank the tumor tissues within their brains.

"Thus, TPR can serve as a potential biomarker, and MTOR inhibition could be an effective therapeutic approach for ependymoma patients," conclude the researchers. While looking out for increased levels of TPR in patients can help oncologists achieve a more comprehensive diagnosis, reducing TPR levels with the help of drugs can help keep the tumors in check.

Background:

Autophagy: Autophagy, which literally translates to "self-eating" is the self-preservation mechanism of the body to get rid of damaged cells. Autophagy is initiated when an abnormal amount of proteins or toxins build up within a cell, which the cell cannot clear out. Conditions like Alzheimer's disease and Parkinson's disease arise when autophagic mechanisms within the cells start malfunctioning. Impaired autophagy is also known to be implicated in driving various forms of cancer.

Reference

Firli Rahmah Primula Dewi, Shabierjiang Jiapaer, Akiko Kobayashi, Masaharu Hazawa, Dini Kurnia Ikliptikawati, Hartono, Hemragul Sabit, Mitsutoshi Nakada, and Richard W. Wong. "Nucleoporin TPR (translocated promoter region, nuclear basket protein) upregulation alters MTOR-HSF1 trails and suppresses autophagy induction in ependymoma", Autophagy. Published online 24March2020.

DOI 10.1080/15548627.2020.1741318.

About Nano Life Science Institute (WPI-NanoLSI)

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Nano Life Science Institute (NanoLSI), Kanazawa University is a research center established in 2017 as part of the World Premier International Research Center Initiative of the Ministry of Education, Culture, Sports, Science and Technology. The objective of this initiative is to form world-tier research centers. NanoLSI combines the foremost knowledge of bio-scanning probe microscopy to establish 'nano-endoscopic techniques' to directly image, analyze, and manipulate biomolecules for insights into mechanisms governing life phenomena such as diseases.

About Kanazawa University

http://www.kanazawa-u.ac.jp/e/

As the leading comprehensive university on the Sea of Japan coast, Kanazawa University has contributed greatly to higher education and academic research in Japan since it was founded in 1949. The University has three colleges and 17 schools offering courses in subjects that include medicine, computer engineering, and humanities.

The University is located on the coast of the Sea of Japan in Kanazawa a city rich in history and culture. The city of Kanazawa has a highly respected intellectual profile since the time of the fiefdom (1598-1867). Kanazawa University is divided into two main campuses: Kakuma and Takaramachi for its approximately 10,200 students including 600 from overseas.

Further information

Hiroe Yoneda Vice Director of Public AffairsWPI Nano Life Science Institute (WPI-NanoLSI)Kanazawa UniversityKakuma-machi, Kanazawa 920-1192, JapanEmail: nanolsi-office@adm.kanazawa-u.ac.jp Tel: +81-(76)-234-4550

SOURCE Kanazawa University

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Researchers measure radar cross sections to improve drone detection – Aerospace Testing International

Researchers from Finland, Belgium and the USA have measured the radar cross sections of drones to establish an open-database of known types and improve drone detection methods.

With drones being increasingly used across society and industry for many different applications, they can cause public harm and be used maliciously. The researchers hope the database can be used to help design radar systems and new drone detection techniques to improve public safety.

Radar is commonly used to monitor the presence of drones and prevent possible threats. However, drones are manufactured in a range of sizes, shapes and often use composite materials, making them challenging to detect with radar.

Researchers from Aalto University in Finland, UCLouvain in Belgium, and New York University, USA have gathered extensive radar measurement data of commercially available and custom-built drone models Radar Cross Section (RCS), which indicates how the target reflects radio signals. The RCS signature can help to identify the size, shape and the material of the drone.

Researcher Vasilii Semkin from Aalto University said, We measured drones RCS at multiple 26-40 GHz millimetre-wave frequencies to better understand how drones can be detected and to investigate the difference between drone models and materials in terms of scattering radio signals.

We believe that our results will be a starting point for a future uniform drone database. Therefore, all results are publicly available along with our research paper.

The publicly accessible measurement data could be used in the development of radar systems, as well as machine learning algorithms for more complex identification. This would increase the probability of detecting drones and reducing fault detections.

There is an urgent need to find better ways to monitor drone use. We aim to continue this work and extend the measurement campaign to other frequency bands, as well as for a larger variety of drones and different real-life environments, added Semkin.

Researchers are now studying the possibility that5G base stations could be used in the futurefor surveillance.

We are developing millimetre-wave wireless communication technology, which could also be used in sensing the environment like a radar. With this technology, 5G-base stations could detect drones, among other things, said professorVille Viikarifrom Aalto Universitys Department of Electronics and Nanoengineering.

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Texas A&M Hagler Institute Inducts 2019-2020 Faculty Fellows, Distinguished Lecturers – Texas A&M University Today

The Hagler Institute for Advanced Study at Texas A&M recently inducted its 2019-20 class of Hagler Fellows. Pictured front row from left: Mario Andrs Hamuy, Deirdre N. McCloskey, Sharon M. Donovan, Edwin L. Ned Thomas, and Peter W. Shor. Back row from left: Kathleen C. Howell, Luiz Davidovich, Misha Lyubich, and Hagler Institute founding director John L. Junkins. Not pictured: Peter J. Hotez and Henry Rousso.

Photo courtesy of Butch Ireland

The Hagler Institute for Advanced Study at Texas A&M University inducted nine Hagler Fellows into the 2019-20 class during its eighth annual gala on Friday, Feb. 28.

The faculty fellows are distinguished in the advancement of research in aeronautics and astronautics, astronomy, history, law, physics, mathematics, materials science and nanoengineering, nutrition and health and tropical medicine. The institute also honored its distinguished lecturers for the 2019-20 academic year.

In remarks to the 200-plus audience in the Bethancourt Grand Ballroom at the Memorial Student Center, Chancellor John Sharp of The Texas A&M University System regarded the Hagler Institute as one of the greatest ways to incorporate distinction and reach Texas A&Ms high standard for academic achievement.

The quality of the professors to come to us through the Hagler Institute for Advanced Study has been nothing short of extraordinary, Sharp said.

Texas A&M President Michael K. Young began by thanking Founding Director John Junkins for his vision and commitment to the institute. Young also thanked Jon Hagler for his generosity and dedication to excellence.

By investing in the excellence of intellectual explorers like the ones we welcome tonight, he has ensured his lasting legacy as a catalyst for groundbreaking scholarship and discovery, Young said.

Keynote speaker Norman Augustine, former chair and CEO of Lockheed Martin and current chair of the Hagler Institutes External Advisory Board, referenced the progress the Hagler Institute has made over the last decade.

Its remarkable growth has been possible by the early support of Chancellor Sharp and the continuing support of President Young as the Hagler Institute now moves into Phase 2.0, Augustine said. Their confidence and the confidence of people like this audience, along with the infinite energy and persistence of John Junkins, have turned a fragile idea into a remarkable institution.

Augustine urged the audience to actively support the work of the Hagler Institute.

Education and research are the engines that drive our economy, and our economy is the engine that, to a considerable extent, drives the quality of our lives, he said.

This years induction of Hagler Fellows includes members of the National Academies of Sciences, Engineering and Medicine, the American Academy of Arts and Sciences and equivalent academies around the world, bringing the total number of past and present Hagler Fellows to 70. Each fellow collaborates with one or more of Texas A&Ms colleges or schools.

The Hagler Institute also formally welcomed its Distinguished Lecturers for 2019-2020.

About the Hagler Institute for Advanced Study: The Hagler Institute for Advanced Study was established in December 2010 by The Texas A&M University System Board of Regents to build on the growing academic reputation of Texas A&M and provide a framework to attract top scholars from throughout the nation and abroad for appointments of up to a year. The selection of Faculty Fellows initiates with faculty nominations of National Academies and Nobel Prize-caliber scholars who align with existing strengths and ambitions of the University. To learn more, visit the Hagler Institute webpage.

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Texas A&M Hagler Institute Inducts 2019-2020 Faculty Fellows, Distinguished Lecturers - Texas A&M University Today

Smart Materials May Find New Option with Light-Powered Micromotor – ENGINEERING.com

Smart Materials May Find New Option with Light-Powered MicromotorJeffrey Heimgartner posted on March 04, 2020 | Researchers have developed a 5mm micromotor powered by light.

When it comes to converting energy into movement, rotary motors have proven their worth. As new innovations and technology continue to get smaller in size, miniaturizing these kinds of motors has been a focus for researchers at the University of Warsaw. Working with colleagues from the Department of Mathematical Sciences at Xian Jiaotong-Liverpool University in Suzhou, China, the Institute of Applied Physics at Military University of Technology in Warsaw, and the Centre of Polymer and Carbon Materials of Polish Academy of Sciences in Zabrze, Poland, the team developed a micromotor powered by light that could potentially make it easier to miniaturize other components.

Movie of the 5.5 mm diameter micromotor, driven by a rotating laser beam. (Source: UW Physics, Mikoaj Rog)

Despite low speed, around one rotation per minute, our motor allows us to look at the micromechanics of intelligent soft materials from a different perspective and gives food for thought when it comes to their potential use, said Klaudia Dradrach, Photonic Nanostructure Facility.

A 5mm diameter micromotor rotor, made of specially oriented polymer film, fits on a pencil tip. (Image courtesy of the University of Warsaw, Piotr Wasylczyk.)

Since LCEs are considered a smart material, which can be fabricated in a multitude of ways and sizes, the new motor could open doors for new innovations. The new motor, along with the right orientation of the LCEs, could help power and control robotic components with light. It also has the potential to change how wearable smart materials could be made and operate.

With the success of their current micromotor, the researchers are now focusing their efforts on light-controlled microtools and long-range linear actuators.

Interested in more ways tiny innovations are set to make a big difference? Check out Nanoparticles Pave the Way for a Million-Mile EV Battery and Composite Enhancing Nano-Barrier Could Change Spacecraft Construction.

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Smart Materials May Find New Option with Light-Powered Micromotor - ENGINEERING.com

Here’s how nanoparticles could help us get closer to a treatment for COVID-19 – News@Northeastern

There is no vaccine or specific treatment for COVID-19, the disease caused by the severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2.

Since the outbreak began in late 2019, researchers have been racing to learn more about SARS-CoV-2, which is a strain from a family of viruses known as coronavirus for their crown-like shape.

Northeastern chemical engineer Thomas Webster, who specializes in developing nano-scale medicine and technology to treat diseases, is part of a contingency of scientists that are contributing ideas and technology to the Centers for Disease Control and Prevention to fight the COVID-19 outbreak.

Professor and chair of the Department of Chemical Engineering Tom Webster. Photo by Adam Glanzman/Northeastern University

The idea of using nanoparticles, Webster says, is that the virus behind COVID-19 consists of a structure of a similar scale as his nanoparticles. At that scale, matter is ultra-small, about ten thousand times smaller than the width of a single strand of hair.

Webster is proposing particles of similar sizes that could attach to SARS-CoV-2 viruses, disrupting their structure with a combination of infrared light treatment. That structural change would then halt the ability of the virus to survive and reproduce in the body.

You have to think in this size range, says Webster, Art Zafiropoulo Chair of chemical engineering at Northeastern. In the nanoscale size range, if you want to detect viruses, if you want to deactivate them.

Finding and neutralizing viruses with nanomedicine is at the core of what Webster and other researchers call theranostics, which focuses on combining therapy and diagnosis. Using that approach, his lab has specialized in nanoparticles to fight the microbes that cause influenza and tuberculosis.

Its not just having one approach to detect whether you have a virus and another approach to use it as a therapy, he says, but having the same particle, the same approach, for both your detection and therapy.

SARS-CoV-2 spreads mostly through tiny droplets of viral particlesfrom breathing, talking, sneezing, coughingthat enter the body through the eyes, mouth, or nose. Preliminary research also suggests that those germs may survive for days when they attach themselves to countertops, handrails, and other hard surfaces.

Thats one reason to make theranostics with nanoparticles the focus of the COVID-19 outbreak, Webster says.

Nanoparticles can disable these pathogens even before they break into the body, as they hold on to different objects and surfaces. His lab has developed materials that can be sprayed on objects to form nanoparticles and attack viruses.

Even if it was on a surface, on someones countertop, or an iPhone, he says. It doesnt mean anything because its not the active form of that virus.

That same technology can be fine-tuned and tweaked to target a wide range of viruses, bacteria, and other pathogens. Unlike other novel drugs with large molecular structures, nanoparticles are so small that they can move through our body without disrupting other functions, such as those of the immune system.

Almost like a surveyor, they can go around your bloodstream, Webster says. They can survey your body much easier and under much longer times and try and detect viruses.

To do all that, the CDC needs to know the specifics about what kind of structure is needed to neutralize SARS-CoV-2, Webster says. That information isnt public yet.

You have to identify what we need to put in our nanoparticle to attract it to that virus, he says. The CDC must know that, because theyve developed a kit that can determine if you have [COVID-19], versus influenza, or something else.

An alternative to nanomedicine is producing synthetic molecules. But Webster says that tactic presents some challenges. In the case of chemotherapies used to treat cancer cells, such synthetic drugs can cause severe side effects that kill cancer cells, as well as other cells in the body.

The same thing could be happening with synthetic chemistry to treat a virus, where molecules are killing a lot more than just that virus, Webster says.

Still, Webster acknowledges that there arent many researchers focusing on nanoparticles to kill viruses.

One of the main reasons for the lack of those solutions is that the same benefits that make nanoparticles ideal to fight infectious diseases also make them a concern for the U.S. Federal Drug Administration.

Because of their size, nanoparticles are pervasive (too pervasive, maybe) to seep through other parts of the body. To reduce that risk, Websters lab has focused on using iron oxide. Particles of that make up entail chemistry that is already natural to our bodies and diets.

Even if you have a viral infection, you need more iron, because you could be anemic depending on how bad the infection is, Webster says. Were actually developing these nanoparticles out of chemistries that can help your health.

And, he says, iron-based nanoparticles could be directed with magnetic fields to target specific organs in the body, such as lungs and other areas susceptible to respiratory complications after contracting viral infections. That too, Webster says, is something that you couldnt do with a novel synthetic molecule.

Really, what this all means is that we just have to do the studies to show those iron nanoparticles are not going into the brain or the kidney, Webster says, that these nanoparticles are going exactly where you want them to go to the virus.

For media inquiries, please contact Shannon Nargi at s.nargi@northeastern.edu or 617-373-5718.

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UA developing wearable technology to measure sweat ‘biomarkers’ – Tucson Local Media

Researchers at the University of Arizona are developing wearable technology to analyze sweat, which may remove the need to draw blood to learn about the bodys functions in multiple situations.

The project is funded by an 18-month, $519,000 grant from the SEMI Nano-Bio Materials Consortium. The project falls at the crossroads of multiple academic fields, including engineering, chemistry and medicine, and has two main goals: develop a patch to reliably collect the sweat, and develop a biochemistry sensor to analyze the sweat.

When physicians take blood samples, the blood is tested for "biomarkers" which are indicators of medical phenomena like disease or infection. Sweat contains its own index of biomarkers, and collecting it presents a unique series of challenges and advantages.

No matter what molecule you measure in sweat, you need to determine how it relates to the physiological status of the individual, says co-investigator Esther Sternberg, who serves as research director for the Andrew Weil Center for Integrative Medicine and UA professor of medicine. In order to measure the status of the immune system without stressing an individual, one needed to get at immune molecules in a different way than drawing blood, because if you draw blood you need to stick a needle in a person, and thats a stressor If youre trying to understand how the stress response affects the immune response, you need to have a noninvasive, unobtrusive way of measuring the status of the immune response.

Sternberg began working with biomarkers in sweat 20 years ago while working at National Institutes of Health. She says one of the reasons she was drawn to the UA was because of interdisciplinary research projects such as this.

Part of understanding biomarkers in sweat involves using a sweat correlation lab where subjects use exercise bikes to have their sweat collected in a controlled environment.

Were able to relate the levels of the different biomarkers to the exact amount of stress that their bodies are experiencing because we correlate them with heart rate, heart rate variability, breathing and other well-standardized methods to accurately measure the activity of the brain and bodys stress response, Sternberg says. Just measuring the molecules is just the tip of the iceberg, you need to correlate them with all these different measures of the status of the physiological stress response in order to understand what they mean and have actionable results.

One of the first hurdles is how to accurately and quickly collect the sweat. According to project principal investigator Erin Ratcliff, a materials science and engineering professor and head of the UA Laboratory for Interface Science of Printable Electronic Materials, the obvious idea to collect sweat would be to make a patch to gather information from multiple pores at once. However, this means waiting for the space between the patch and skin to fill up with sweat, and during that time, the molecules and biomarkers can chemically change, altering important information.

Ratcliff became involved in this project five years ago, and her role is to convert the biomarkers into an electronic signal that devices use. Current wearable technologies, such as a FitBit, measure bodily data like EKG and heart rate, but dont measure the molecules behind the stress responses, such as cortisol or neuropeptide Y.

Part of the project uses a virtual sweat sensing lab which is a computer simulation that allows researchers to input information about biomarkers, printable materials and device architectures to determine what the output of a sensor would be before they ever make it.

The prototypes that will come out of this 18-month project will be laboratory level with the idea that the components will lead to a product stream for a particular company, but were not going to make thousands of them, Ratcliff says.

While Sternberg says measuring sweat has a tremendous and very wide applicability to many different diseases, it will not completely remove the need to draw blood.

Youre getting information from two different compartments of the body; the blood tells you whats going on in the blood and circulatory system, and sweat tells you whats going on in the tissues and peripheral nervous system I believe this will enhance information and give you information that is not present when you only measure molecules in blood, Sternberg says. Ultimately there may be circumstances in which collecting sweat and collecting molecules from sweat will replace the need to measure the molecules in blood, and in other cases to get a full picture of whats happening in the body, you may need to measure sweat, blood, saliva, urine and on and on.

The U.S. Department of Defense measures "technology readiness" throughout nine levels. According to Ratcliff, the team is aiming for the technology to be at level four at the end of this project. Technology Readiness Level Four means that "basic technological components are integrated to establish that they will work together.

This speaks to the importance of academe and industry working together in an unbiased way, together with federal agencies, to solve complex problems which cant be solved only on the academic side or only on the industry side, Sternberg says. This is an interdisciplinary, multi-college collaboration with an engineer of materials science in Erin Ratcliff, a chemist Ray Runyon, and myself a physician When youre talking about cutting-edge, frontier science, that is the way science has to be done.

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UA developing wearable technology to measure sweat 'biomarkers' - Tucson Local Media

Chemistry’s Mahsa Lofti-Marchoobeh Wins Three Minute Thesis Final – University of Arkansas Newswire

Photo submitted by the Office of Graduate Student Support.

Mahsa Lotfi-Marchoobeh delivers her 3MT presentation to the audience.

Mahsa Lotfi-Marchoobeh is the winner of the University of Arkansas Three Minute Thesis competition. She earned the top prize for her presentation A Miniaturized Neural Probe for Detection of Chemicals in the Brain.

As the top finisher, Lotfi-Marchoobeh won $750 and entry to the Conference of Southern Graduate Schools' regional Three Minute Thesis contest.

Lotfi-Marchoobeh is a doctoral student in the Department of Chemistry and Biochemistry and is advised by Ingrid Fritsch. In the regional contest Lotfi-Marchoobeh will compete against roughly 80 students from universities across the Southern Region. The contest will be held March7 in Birmingham, Alabama.

Abass Oduola and Firuze Kordshuli tied for the People's Choice award, voted on by members of the audience. They each won $500 for their presentations. Oduola, a cell and molecular biology doctoral student advised by Griffiths Atungulu, presented Impact of Selected Infrared Wavelengths on Inactivation of Microbes on Rough Rice. Kordshuli presented Incorporation of Cu-SIO2 Nano Particles in PDA/PTFE Thin Films, as part of her doctoral research in mechanical engineering with advisor Min Zou.

Lotfi-Marchoobeh, Oduola and Kordshuli were three of five students who earned a spot in the University of Arkansas final. Each student booked their spot in the final by winning contests in their academic colleges in February.

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Chemistry's Mahsa Lofti-Marchoobeh Wins Three Minute Thesis Final - University of Arkansas Newswire

NASA-funded professor charged with hiding Chinese university ties – The College Fix

Affiliation noted on Chinese university website, research papers, patent applications

A professor kept working for a Chinese university after being hired by the University of Tennessee-Knoxville and failed to disclose the relationship, even after he applied for tenure, according to a federal indictment.

Anming Hu, associate professor in the Department of Mechanical, Aerospace and Biomedical Engineering, was arrested last week andcharged with three counts each of wire fraud and making false statements, the Justice Department said. The university says it has suspended him.

The most serious allegations against Hu stem from his acceptance of funding from NASA while semi-covertly working for Beijing University of Technology, which would violate federal law on NASA funding restrictions. The Knoxville News Sentinel reports:

In 2016, Hu prepared a proposal to work on a NASA-funded project and was informed by a UT employee of the funding restrictions surrounding Chinese companies and universities.

Still, Hu continued to seek and receiveNASA funds for research projects, the indictment states. Later that year, UT submitted aproposal for Hu called, Nanobrazing stainless steel containers for breaking the chain-of-contact (BTC) Mars Sample Return Mission, and in 2018, the university submitted one called,Printed metallic sensors based on 3D printing and laser sintering of nanoinks.

Hu worked on those two projects, for which NASA shelled out $105,000, according to the indictment.

The charges against Hu stem from emails and invoices sent in connection to those projects.

Hu hid his employment with the Beijing university even before UTK hired him in 2013, leaving his position with its Institute of Laser Engineering off his application, according to the indictment. He allegedly checked no on UTK forms that asked him if he worked for any organization or business entity other than UTK.

Yet his name and Beijing university affiliation showed up in multiple public places the university website, at least six published research papers and a dozen patent applications filed in China:

Hu also supervised graduate students in the Institute of Laser Engineering,worked on projectssponsored by the Chinese government and remotely oversawthe operation of a lab in Beijing.

My group there is focusing on super-resolution nano manufacturing and printable electronics, Hu wrote in an email to a U.S. professor in 2017.

The Justice Department said Hu is facing up to 75 years in prison and $750,000 fines if convicted on all counts.

Read the Justice statement and News Sentinel report.

h/t Inside Higher Ed

MORE: Prosecutors call Harvard department chair a secret Chinese agent

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Devro lifted by confidence over growth in 2020 – Proactive Investors UK

Devro PLC (LON:DVO) shot up 7% to 157.4p as it said it expects to achieve good progress in 2020 with volume growth in all its markets.

The producer of sausage casings added that cost savings will more than offset cost pressures due to inflation.

In the year to 31 December, it swung to a 21mln loss before tax, from a 17mln profit in 2018, due to closure of a UK facility and non-cash impairment charges related to US and Chinese plants.

TT Electronics plc (LON:TTG) advanced 9% to 208p as the majority of its operations in Asia have restarted after closing to prevent the coronavirus from spreading.

The manufacturer of electronic components has three facilities in China and one in Hong Kong, accounting for 25% of its total revenues.

The company said the closures will hit this years profits by 3mln.

Edenville Energy PLC dipped 2% to 0.044p on Wednesday afternoon as it expects further disruption at its Rukwa mine in Tanzania if the rains continue.

The AIM-listed coal producer said it expects to start mining from the northern area of the project during this month, as the ramp-up in production continues.

The plant is taking material from the 6,000-tonne stockpile established last month which needs to be replenished.

Fellow miner Condor Gold PLC (LON:CNR) was doing much better, rising 9% to 31.75p.

The AIM-listed firm said results from mining dilution studies supporting a 1,000 tonnes per day production feed at the La India project in Nicaragua.

Management said it could be possible by establishing a small plant or a toll milling agreement.

Amigo Holdings PLC (LON:AMGO) jumped 11% to 43.99p inearly afternoon trade as it announced that its founder James Benamor has resigned with immediate effect.

Benamor forced his way back on to the board at the guarantor loans lender in December after resigning post-float in 2018.

Amigo embarked in a transformation programme in August and recently was given some feedback from theFinancial Conduct Authority over areas for improvement, such as increasing the explanation of key information provided to potential guarantors and disclosure on the likelihood that guarantors could be called to make payments.

Meanwhile, Haydale Graphene Industries PLC (LON:HAYD) surged 11% to 1.75p after it said its graphene nano-platelets have been incorporated into a cosmetic face mask recently launched by South Korean firm iCraft.

The masks will utilise the thermal and electrical conductivity of graphene to help the skin absorb its contents.

The AIM-listed firm said thatwhile the initial volume of graphene required to meet early-stage demand may not be significant, the deal marked a significant step-change in the use of the material.

Attraqt Group PLC (LON:ATQT) slid 18% to 32p as its full-year loss before tax widened by 38% to 4mln due to higher staff, research and development costs.

The e-commerce solutions provider said it still expects double-digit growth in its 2020 annual recurring revenue.

Elsewhere, Hostelworld Group PLC (LON:HSW) shed 10% to 94.6p after warning the coronavirus outbreak could hit its quarterly earnings by 4mln.

The budget accommodation provider said trading since late-January had been challenged by the outbreak with a significant impact on global travel demand, particularly within Asia and Europe.

As the coronavirus has spread from region to region, we have observed a material reduction in bookings and an increase in marketing cost as a percentage of net revenue, the company said.

Urban Exposure PLC (LON:UEX) shot up 10% to 64.98p mid-morning after confirming it is in exclusive discussions with Pollen Street Capital following media speculation.

The finance provider to property developers is looking to offload its loan book to Pollen Street, while the existing executive team would buy its asset management business.

If all goes ahead, the firmwill de-list from AIM and return 73p per share to its shareholders.

Meanwhile, Oncimmune Holdings PLC (LON:ONC) jumped 8% to 88p after praising its US partner Biodesix for exceeding expectations.

The two firms have agreed to sell Oncimmunes diagnostic kit EarlyCDT Lung alongside Biodesixs Notify XL2.

They will be offered via a national sales force plugged directly into pulmonologists and, corporately, into national hospital systems.

In the chemicals industry, Itaconix PLC (LON:ITX) advanced 7% to 1.66p on the back of a joint development agreementfor a biodegradable packaging venture.

According to the deal, the unnamed partner will evaluate the use of Itaconix's BIO*Asterix line of functional additives in new biodegradable packaging solutions.

Itaconix said that if the efforts are successful it will produce and supply one or more BIO*Asterix additives for the partner to use in its product range.

Proactis Holdings PLC (LON:PHD) was a bigearly faller on Wednesday, crashing 38% lower to 29p as it revealed it is no longer up for sale.

The business e-commerce solutions provider announced a formal sale process last July but said today that it did not lead to any firm proposals.

The company has now committed to make a series of changes to keep shareholders happy, including the annual re-election of directors.

Similarly, Nanoco Group PLC (LON:NANO) shares tanked 36% to 16p as it said it has not received a formal acquisition offer after months of discussions.

The nano-materials firm, however, said it is still engaging with a number of parties hoping someone will pop the question.

The firm added it continues to review all strategic options including additional funding.

Meanwhile, Intu Properties PLC(LON:INTU) dropped 26% to 7.91p as the shopping centres firm revealed it hasfailed to raise the 1bn-1.5bn lifeline it hadhoped for.

The real estate group said in January that it was in talks with investors, but noted today that many of them were not willing to dish out the money in such an uncertain market.

The firm said other options are being explored, including alternative capital structures and asset disposals, after several expressions of interest.

Sirius Minerals PLC (LON:SXX) is set to be acquired by Anglo American Plc(LON:AAL) for 405mln after its offer was approved at yesterday's shareholder meeting. Over 1,300 investors cast their vote on Tuesday with 80.28% in favour. The offer needed 75% approval to go ahead.

Itaconix PLC (LON:ITX) has inked a joint development agreement for a biodegradable packaging venture. The agreement envisages a collaboration to evaluate the use of Itaconix's BIO*Asterix line of functional additives in new biodegradable packaging solutions.

Haydale Graphene Industries PLCs (LON:HAYD) graphene nano-platelets have been incorporated into a cosmetic face mask recently launched by South Korean firm iCraft. The company said the masks will utilise the thermal and electrical conductivity of graphene to help the skin absorb its contents.

Oncimmune Holdings PLC (LON:ONC) chief executive Adam Hill has heaped praise on the companys American partner following the launch of its lung diagnostic into the worlds largest healthcare market. Biodesix Inc exceeded our expectations, Hill said. Oncimmunes EarlyCDT Lung test will be sold in the US as Notify Lung for use by doctors in identifying nodules at high risk of lung cancer.

SDX Energy PLC (LON:SDX) told investors that the BMK-1 exploration well has encountered commercial quantities of gas in two targeted horizons. BMK-1 was described previously as a play-opening well and the result confirms that the core productive area in Morocco extends north, de-risking some 20bn cubic feet of prospective gas resources. The result is expected to significantly extend the life of resources.

BATM Advanced Communications Ltd (LON:BVC) has seen earnings double in 2019 after what its chief executive said was a great performance in the second half. For the year ended 31 December, the networking tech and bio-medical firm reported earnings (EBITDA) of US$9.8mln, up from US$4.9mln in 2018, while revenues rose to US$123.4mln from US$119.6mln. Adjusted operating profit, meanwhile, was up to US$5.3mln from US$2.6mln.

Allergy Therapeutics PLC (LON:AGY) has made a steady start to the financial year, according to its chief executive Manuel Llobet with revenue and profit up, respectively, by 9% and 10% backed by a strong operational performance. Turnover for the six months to December 31 advanced to 50.5mln from 46.7mln as the firm reported good growth across the product portfolio and a small gain in European market share.

Xpediator PLC (LON:XPD) has taken out a 20-year lease on a new 200,000 sq ft distribution centre at Southampton's container port. The opening of this new facility will take the freight companys UK warehousing capability to approximately 700,000 sq ft with the new distribution centre scheduled to be built in 2021.

Argo Blockchain PLC (LON:ARB) has reported a 56% increase in monthly income from its Bitcoin mining operation while also completing a capacity expansion ahead of schedule. In a monthly update, the cryptomining firm said it had mined around 337.5 Bitcoin equivalent in February, a 37% increase on Januarys figure, generating revenues of 2.54mln compared to 1.63mln in the prior month.

Tekcapital PLC (LON:TEK) revealed that its portfolio company, Salarius Ltd. has signed an agreement with iLevel Brands Inc as part of the launch of North American sales of its new SaltMe! full flavour-low sodium snack line. The UK intellectual property investment group which is focused on creating marketplace value from investing in university technology - said the agreement, combined with a previously announced distribution agreement, will expand Salarius' market penetration and brand awareness for its new potato chip snack line with retail brand placements across the entire East Coast, Midwest and Southwest geographic areas of the United States.

Seeing Machines Limited (LON:SEE) has appointed Stifel Nicolaus Europe Limited as its joint broker with immediate effect to assist in broadening the groups investor base across North America. The advanced computer vision technology company, which designs AI-powered operator monitoring systems to improve transport safety, said Stifels appointment follows a successful introduction to US-based investors in New York in January.

Condor Gold PLC (LON:CNR) has published a low-capex, high-grade open pit mining scenario based on updated mining dilution studies for the La India Gold Project, located in Nicaragua. These dilution studies have demonstrated that Condor Gold could use a selective mining approach to focus on mining lower-volumes of high-grade mineralisation, reducing the size of the required plant and as a result reducing the amount of capex required to build the plant. Alternatively, the focus on high-grade mineralisation could support a toll treatment operation with a nearby plant owned by another operator.

PCF Group Plc (LON:PCF), the AIM-listed specialist bank, has advised that given the current concerns surrounding travel the bank will be offering shareholders the option of viewing the its forthcoming AGM remotely via an online video stream. The group said this does not affect any of the other arrangements for the AGM, which will take place as previously announced at 1 Cornhill, London EC3V 3ND on Friday 6th March 2020 at 10.00am, and to which shareholders remain welcome to attend in person.

Ergomed PLC (LON:ERGO), a company focused on providing specialised services to the pharmaceutical industry, will announce its preliminary results for the year ending 31 December 2019 on 25 March 2020. The group added that Miroslav Reljanovi, its executive chairman, Richard Barfield, chief financial officer and Lewis Cameron, chief operating officer will host a presentation and conference call for analysts at 9.30am GMT on the day of the results at the offices of Numis, 10 Paternoster Square, London EC4M 7LT.

Original post:

Devro lifted by confidence over growth in 2020 - Proactive Investors UK

New Method Helps Observe the Dynamic Motion of Atoms in 2D Materials – AZoNano

Written by AZoNanoFeb 12 2020

Materials science researchers from McCormick School of Engineering of Northwestern University have developed atechnique to observe the atoms dynamic movement in atomically thin two-dimensional (2D) materials.

The new imaging method, which demonstrates the fundamental cause responsible for the performance failure of an extensively-used 2D material, can help scientists to create more reliable and stable materials for upcoming flexible electronic devices and wearables.

These 2D materialsnamely borophene and grapheneare a group of single-layer, crystalline materials that have great potential as semiconductors in next-generation flexible and ultra-thin electronics.

However, the thin nature of these materials makes them extremely susceptible to external settings, and, as a result, they have struggled to show long-term reliability and stability when used in electronic devices.

Atomically thin 2D materials offer the potential to dramatically scale down electronic devices, making them an attractive option to power future wearable and flexible electronics,

Vinayak Dravid, Abraham Harris Professor, Department of Materials Science and Engineering, McCormick School of Engineering, Northwestern University

The study, titled Direct Visualization of Electric Field-induced Structural Dynamics in Monolayer Transition Metal Dichalcogenides, was published in the ACS Nano journalon February 11th, 2020.

The studys corresponding author is Vinayak Dravid.The research also involved Chris Wolverton, the Jerome B. Cohen Professor of Materials Science and Engineering,

Unfortunately, electronic devices now operate as a kind of black box. Although device metrics can be measured, the motion of single atoms within the materials responsible for these properties is unknown, which greatly limits efforts to improve performance, Dravid stated.

Dravid serves as a director of the Northwestern University Atomic and Nanoscale Characterization (NUANCE) Center. The study provides a means to move beyond that restriction, with a new insight into the structural dynamics involved in 2D materials receiving electrical current.

Based on an earlier study where the scientists utilized a nanoscale imaging method to visualize heat-induced failure in 2D materials, the team employed a high-resolution, atomic-scale imaging technique known as electron microscopy to view the motion of atoms in molybdenum disulfide (MoS2). MoS2 is an extensively researched material that was initially utilized as a dry lubricant in friction materials and greases; this dry lubricant was recently in the limelight for its optical and electronic properties.

Upon applying an electric current to the material, the scientists observed that the highly mobile sulfur atoms in this material always move to empty areas within the crystalline material, a phenomenon which the team called atomic dance.

That movement of the atomscaused the grain boundaries of MoS2 to separate and form narrow channels for the electrical current to pass through. Grain boundaries are natural defects produced in the space, where a pair of crystallites inside the material meet.

As these grain boundaries separate, you are left with only a couple of narrow channels, causing the density of the electrical current through these channels to increase. This leads to higher power densities and higher temperatures in those regions, which ultimately leads to failure in the material.

Akshay Murthy, Study Lead Author and PhD Student, Department of Materials Science and Engineering, Northwestern University

Murthy is part of Dravids team.

Its powerful to be able to see exactly whats happening on this scale, continued Murthy. Using traditional techniques, we could apply an electric field to a sample and see changes in the material, but we couldnt see what was causing those changes. If you dont know the cause, its difficult to eliminate failure mechanisms or prevent the behavior going forward.

With this latest method to analyze 2D materials at the atomic level, the researchers believe that investigators can apply this imaging technique to produce materials that are less likely to fail in electronic devices.

For instance, in memory devices, scientists can visualize how regions where data is stored, emerge upon applying an electric current and adapt how those kinds of materials are developed for more improved performance.

The method may even help to enhance a range of other technologies, such as light-emitting diodes (LEDs) in consumer electronics, transistors in bioelectronics, and photovoltaic cells integrated with solar panels.

We believe the methodology we have developed to monitor how 2D materials behave under these conditions will help researchers overcome ongoing challenges related to device stability. This advance brings us one step closer to moving these technologies from the lab to the marketplace.

Akshay Murthy, Study Lead Author and PhD Student, Department of Materials Science and Engineering, Northwestern University

Source: https://www.mccormick.northwestern.edu/

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New Method Helps Observe the Dynamic Motion of Atoms in 2D Materials - AZoNano

Surgical Instruments Tracking Systems Market Development and New Market Opportunities and Forecasts 2028 – Jewish Life News

Surgical Instruments Tracking Systems Market: Introduction

Surgical instruments tracking systems have been accessible for use in medical field for several years. Today, surgical instruments tracking systems have turned into a need. The previous four to five years have witnessed major changes in tracking systems. Rapid advances in instruments tracking systems technologies such as nano-engineering and opto-electrical engineering have created new avenues in recent years. Need for unobtrusive and automated tracking systems will keep demands lucrative in coming years.

Download Brochure of This Market Report at https://www.tmrresearch.com/sample/sample?flag=B&rep_id=5760

The report by TMR Research takes a closer look at recent trends impacting the revenue potential of various playersand offers insights into imminent investment pockets in key markets.

Surgical Instruments Tracking Systems Market: Key Development

Some of the most prominent competitors operating in the competitive landscape of global surgical instruments tracking systems market include

Most players are embracing a few organic and inorganic and natural systems, for example, new launches and product advancements, mergers and acquisitions, and collaborations alongside expansion on regional and global scale for serving the unmet needs of users.

Request For TOC On this Market Report at https://www.tmrresearch.com/sample/sample?flag=T&rep_id=5760

Surgical Instruments Tracking Systems Market Dynamics

Rising instances of surgical instruments left in the human body after medical procedures and instrument scattering are the main considerations driving the evolution of the surgical instruments tracking systems market. As indicated by the National Center for Biotechnology Information (NCBI), the casualty rate of held surgical articles is around 2.0%. Along these lines, the requirement for cutting edge innovations, for example, 2D scanner tags and RFID to follow the held instruments while the patient is still in the task theater, is rising. This factor is anticipated to push the surgical instruments tracking systems market.

Rising popularity of instruments tracking devices by emergency clinics is another main consideration boosting the market development. Following healthcare gadgets and stock administration during work cycle including medical procedure, post-medical procedure, sanitization, and storage systems are a portion of the serious issues supervised by emergency clinics. Along these lines, they are embracing new technologies to follow these gadgets and systems, which thus is relied upon to stimulate the market.

A portion of the regular instruments that are accidently left in a patients body during medical procedure consists of sponges, blades, needles, electrosurgical adapters, clamps, scalpels, safety pins, scissors, and towels. Among these instruments, towels are probably the most common thing left behind by mistake. Surgical instruments left in patients bodies will in general cut veins and puncture blood vessels that might lead to internal bleeding, creating a pressing need for technologies to track these instruments.

Expanding requirement for stock administration and usage of Unique Device Identification (UDI) guidelines by the FDA are foreseen to drive the market. Innovative headways and initiatives by governments to adopt these gadgets is foreseen to additionally boost the market in the coming years.

Surgical Instruments Tracking Systems Market: Geographical Analysis

In 2018, North America contributed sizable revenue shares in the global surgical instruments tracking systems market. The launch of unique device identification (UDI) framework by the U.S. FDA for accurately identifying proof of medicinal gadgets through their distribution networks is one of the central points credited to this lead. Moreover, the presence of well-established healthcare infrastructure, fast adoption of cutting-edge products, and high per capita healthcare consumption in other developed regions, such as Europe, are foreseen to fuel the global surgical instruments tracking systems market.

About TMR Research:

TMR Research is a premier provider of customized market research and consulting services to business entities keen on succeeding in todays supercharged economic climate. Armed with an experienced, dedicated, and dynamic team of analysts, we are redefining the way our clients conduct business by providing them with authoritative and trusted research studies in tune with the latest methodologies and market trends.

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Surgical Instruments Tracking Systems Market Development and New Market Opportunities and Forecasts 2028 - Jewish Life News

Kanazawa University Research: Combined Drug Treatment for Lung Cancer and Secondary Tumors – Yahoo Finance

KANAZAWA, Japan, Feb. 10, 2020 /PRNewswire/ -- Researchers at Kanazawa University report in the Journal of Thoracic Oncology a promising novel approach for a combined treatment of the most common type of lung cancer and associated secondary cancers in the central nervous system. The approach lies in combining two cancer drugs, with one compensating for a resistance side effect of the other.

In 20 40% of patients with cancer, metastasis (the development of secondary tumors) in the central nervous system (CNS) occurs. CNS metastatis impacts negatively on a patient's quality of life, and is associated with a poor health prognosis. In a form of cancer known as ALK-rearranged non-small-cell lung cancer (NSCLC), CNS metastatis is known to persist when drugs targeting primary tumors are used.Now, Seiji Yano from Kanazawa University and colleagues have investigated the origins for the resistence to such drugs, and tested a new therapeutic strategy on a mouse model.

The researchers looked at the drug alectinib.Although used in standard treatments for advanced ALK-rearranged NSCLC, approximately 20 30% of patients treated with alectinib develop CNS metastatis, which is attributed to acquired resistance to the drug.

By treating mice first injected with tumor cells with alectinib daily for 16 weeks, the scientists obtained a mouse model displaying alectinib resistance.By biochemical analyses of the mouse brains, Yano and colleagues were able to link the resistance to the activation of a protein known as epidermal growth factor receptor (EGFR).This activation is, in turn, a result of an increase in production of amphiregulin (AREG), a protein that binds to EGFR and in doing so 'activates' it.

Based on this insight, the researchers tested the effect of administering drugs used for inhibiting the action of EGFR in combination with alectinib treatment.The experiments showed that a combination treatment of alctinib with either erlotinib or osimertinib two existing EGFR-inibiting drugs prevented the progression of CNS metastasis, controlling the condition for over 30 days.

The scientists conclude that the combined use of alectinib and EGFR-inhibitors could overcome alectinib resistance in the mouse model of leptomeningeal carcinomatosis (LMC), a particular type of CNS metastasis.Quoting Yano and colleagues: "Our findings may provide rationale for clinical trials to investigate the effects of novel therapies dual-targeting ALK and EGFR in ALK-rearranged NSCLC with alectinib-resistant LMC."

Background

Non-small-cell lung cancer

Non-small-cell lung carcinoma (NSCLC) and small-cell lung carcinoma (SCLC) are the two types of lung cancer. 85% of all lung cancers are of the NSCLC type. NSCLCs are less sensitive to chemotherapy than SCLCs, making drug treatment of the highest importance.

Alectinib is a drug used for treating NSCLC, with good efficiency. However, 20-30% of patients taking the drug develop secondary cancer in the central nervous system (CNS), which is associated with an acquired resistance to alectinib.Seiji Yano from Kanazawa University and colleagues have now made progress towards a novel therapy against this resistance: a combination of alectinib with other drugs.

Epidermal growth factor receptor inhibitors

The drugs that Yano and colleagues tested in combination with alectinib on a mouse model were of a type known as epidermal growth factor receptor (EGFR) inhibitors, including osimertinib and erlotinib. Both are being used as medication for treating NSCLC.The former was approved in 2017 as cancer treatment by the U.S. Food and Drug Administration and the European Commission.Yano and colleagues obtained results showing that EGFR inhibitors counteract resistance to alectinib and have therefore potential in novel therapies for NSCLC and secondary cancers in the CNS.

Reference

Sachiko Arai, Shinji Takeuchi, Koji Fukuda, Hirokazu Taniguchi, Akihiro Nishiyama, Azusa Tanimoto, Miyako Satouchi, Kaname Yamashita, Koshiro Ohtsubo, Shigeki Nanjo, Toru Kumagai, Ryohei Katayama, Makoto Nishio, Mei-mei Zheng, Yi-Long Wu, Hiroshi Nishihara, Takushi Yamamoto, Mitsutoshi Nakada, and Seiji Yano. Osimertinib overcomes alectinib resistance caused by amphiregulin in a leptomeningeal carcinomatosis model of ALK-rearranged lung cancer, Journal of Thoracic Oncology, published online on January 21, 2020.

Story continues

DOI: 10.1016/j.jtho.2020.01.001

URL: https://www.sciencedirect.com/science/article/pii/S1556086420300228

About Nano Life Science Institute (WPI-NanoLSI)

Home

Nano Life Science Institute (NanoLSI), Kanazawa University is a research center established in 2017 as part of the World Premier International Research Center Initiative of the Ministry of Education, Culture, Sports, Science and Technology. The objective of this initiative is to form world-tier research centers. NanoLSI combines the foremost knowledge of bio-scanning probe microscopy to establish 'nano-endoscopic techniques' to directly image, analyze, and manipulate biomolecules for insights into mechanisms governing life phenomena such as diseases.

About Kanazawa University

http://www.kanazawa-u.ac.jp/e/

As the leading comprehensive university on the Sea of Japan coast, Kanazawa University has contributed greatly to higher education and academic research in Japan since it was founded in 1949. The University has three colleges and 17 schools offering courses in subjects that include medicine, computer engineering, and humanities.

The University is located on the coast of the Sea of Japan in Kanazawa a city rich in history and culture. The city of Kanazawa has a highly respected intellectual profile since the time of the fiefdom (1598-1867). Kanazawa University is divided into two main campuses: Kakuma and Takaramachi for its approximately 10,200 students including 600 from overseas.

Further information

Hiroe Yoneda Vice Director of Public Affairs WPI Nano Life Science Institute (WPI-NanoLSI) Kanazawa University Kakuma-machi, Kanazawa 920-1192, Japan Email: nanolsi-office@adm.kanazawa-u.ac.jpTel: +81-(76)-234-4550

View original content:http://www.prnewswire.com/news-releases/kanazawa-university-research-combined-drug-treatment-for-lung-cancer-and-secondary-tumors-301001822.html

SOURCE Kanazawa University

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Kanazawa University Research: Combined Drug Treatment for Lung Cancer and Secondary Tumors - Yahoo Finance

Budding engineers told to think innovatively – The Hindu

Dr. B.R. Ambedkar University Registrar K. Raghu Babu has exhorted budding engineers to concentrate on research and innovative project designs to meet the needs of the generations to come.

Dr. Raghu Babu, who attended as the chief guest for the Inquest-2k20, a two-day technical festival and project expo at Avanthis St. Theresa Institute of Engineering and Technology, Garividi, on Monday, said there were ample opportunities for further research in nano technology, bio-technology and information technology.

Dr. Raghu Babu said the tech fests of this kind would make the youth think innovative and come with fresh ideas which would pave way for their bright future.

JNTU-Vizianagaram College principal G. Swami Naidu urged the students not to copy the ideas for projects as it would kill their talent.

Garividi Mandal Education Officer P. Rama Rao felt that planning, preparation and presentation were important for students pursuing engineering and polytechnic courses.

Avanti college principal M. Srinivasa Rao and vice-principal and director of the college A. Chandra Sekhara Rao expressed happiness over the exhibition of more than 60 projects of the college students and 90 stalls of the schoolchildren of surrounding areas of Garividi.

Solar power enabled cycle, remote controlled grass cutter, Wi-Fi facility for operation of agriculture motor pump sets, intelligent traffic management for emergency vehicles, including ambulances, spying spider robot, railway track damage detection mechanism and other projects were displayed at expo.

Vizianagaram Polytechnic College head of general section L.Vijaya Lakshmi lauded the new ideas of the students while saying that many of them were environment-friendly and would be useful for everyone.

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Budding engineers told to think innovatively - The Hindu

Adoption Scenario of Protein Engineering Market to Remain Positive Through 2015 2021 – Lake Shore Gazette

Proteins are a large group of nitrogenous compounds with high molecular weight, which play an important role in the physiological process and are essential for living organisms. They are composed of one or more chains of amino acids linked by peptide bonds in a particular order to establish the base sequence of nucleotide in the DNA coding for the protein. Each protein has a precise function and is essential for the regulation, functioning, and structure of the bodys cell tissue and organ. Protein engineering is the process of developing valuable proteins or enzyme with a specific function. It is based on the use of the recombinant DNA technology for changing the amino acid sequence. It is used to produce enzyme in large quantities, for producing biological compounds, and to create a superior enzyme to catalyze the production of high value specific chemicals.

Currently, various protein engineering methods are owing to the rapid development in biological science. Some of the methods used for protein engineering are rational design, site directed mutagenesis, random mutagenesis, homology modeling, cell surface display technology, molecular dynamics, and DNA shuffling technology. Mutagenesis and selection are effectively utilized for improving a specific property of an enzyme.

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Meanwhile, the rational design approach is the most classical method in the protein engineering market. It involves site-directed mutagenesis of the protein and allows introduction of specific amino acid into a target gene. Protein engineering has a variety of applications ranging from biocatalysis in food application, to medical, nano-biotechnology, and environmental applications. It is used in the detergent industry, food industry, biopolymer production, applications involving redox proteins and enzymes, medical applications, environmental applications, and nano-biotechnology applications. In medical applications, protein engineering is used for cancer treatment studies.

North America dominates the global market for protein engineering due to the rising prevalence of lifestyle associated diseases and increasing adoption of protein based drugs in the region. Asia Pacific is expected to exhibit high growth rates in the next five years in the global protein engineering market, with China and India being the fastest-growing markets in Asia Pacific. The key driving forces for the protein engineering market in developing countries are the large pool of patients, increasing health care awareness, increasing health care expenditure, rising government initiatives, and rising funding for drug discovery in the region.

Increasing prevalence of lifestyle associated diseases, growing adoption of protein based drugs over non protein based drugs, rising funding for protein engineering, reduction in overall timeline and cost for drug discovery, increase in health care expenditure, and growing health care awareness are some of the key factors that are driving the growth of the global protein engineering market. However, high maintenance, high cost of tools and instruments used in protein engineering, need for qualified researchers and essential training, which increases the cost of the process, and lack of skilled labor act as major restraints for the growth of the global protein engineering market.

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Top selling biologics drugs going off patent in the near future, and protein therapy acting as an alternative to gene therapy are the two major factors that are expected to create opportunities for the global protein engineering market.

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Adoption Scenario of Protein Engineering Market to Remain Positive Through 2015 2021 - Lake Shore Gazette

Consumer Demand for Eco-friendly Products Set to Boost the Prospects of the Digital Servo Press Market 2019 2027 – Redhill Local Councillors

The Digital Servo Press market research encompasses an exhaustive analysis of the market outlook, framework, and socio-economic impacts. The report covers the accurate investigation of the market size, share, product footprint, revenue, and progress rate. Driven by primary and secondary researches, the Digital Servo Press market study offers reliable and authentic projections regarding the technical jargon.

As per the latest business intelligence report published by Transparency Market Research, the Digital Servo Press market has been observing promising growth since the last few years. The report further suggests that the Digital Servo Press market appears to progress at an accelerating rate over the forecast period.

All the players running in the global Digital Servo Press market are elaborated thoroughly in the Digital Servo Press market report on the basis of proprietary technologies, distribution channels, industrial penetration, manufacturing processes, and revenue. In addition, the report examines R&D developments, legal policies, and strategies defining the competitiveness of the Digital Servo Press market players.

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Taxonomy

This research study of the global Nano GPS chipset market provides detailed analysis of different segments of the market. Based on sensitivity, the market has been segmented into 165 dBm & above and below 165 dBm. The 165 dBm & above segment is expected to expand at a rapid pace throughout the forecast period. Based on application, the Nano GPS Chipset Market has been divided into smartphones, wearable, unmanned aerial vehicles (UAVs), asset tracking, personal digital assistants, automotive, and others.

Global Nano GPS Chipset Market: Research Methodology

Secondary research sources that are typically referred to include, but are not limited to: company websites, annual reports, financial reports, broker reports, investor presentations, SEC filings, internal and external proprietary databases, relevant patent and regulatory databases, national government documents, statistical databases, market reports, news articles, press releases, webcasts specific to companies operating in the market, national government documents, and statistical databases.

Primary research involves e-mail interactions, telephonic interviews, and face-to-face interviews for each market segment and sub-segment across geographies. Primary interviews are conducted on an ongoing basis with market participants and commentators in order to validate the data and analysis. Primary interviews provide firsthand information on the market size, market trends, growth trends, competition landscape, and market outlook. These help validate and strengthen secondary research findings. They also help develop the analysis teams market expertise and understanding.

Global Nano GPS Chipset Market: Competition Dynamics

The report covers well-established market players including Broadcom, OriginGPS Ltd., Qualcomm Technologies, Inc., Unicore Communications, Inc., and MediaTek, Inc. These players are engaged in the development of Nano GPS chipsets and their introduction in the market. For instance, in March 2017, OriginGPS Ltd announced release of its new ORG-4500-series GPS module in order to meet the demand for high precision from consumers in commercial, engineering, and defense sectors

The global Nano GPS chipset market has been segmented as follows:

Global Nano GPS Chipset Market, by Sensitivity

Global Nano GPS Chipset Market, by Application

Global Nano GPS Chipset Market, by Region

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Consumer Demand for Eco-friendly Products Set to Boost the Prospects of the Digital Servo Press Market 2019 2027 - Redhill Local Councillors

alwaysAI now open to meet growing demand from computer vision developers – PR Web

SOLANA BEACH, Calif. (PRWEB) February 12, 2020

alwaysAI, a software company dedicated to making computer vision (CV) accessible to all developers with its innovative and easy-to-use platform, announced today that its beta program is open for all software developers to quickly create and deploy CV applications on the edge.

The move builds on the momentum of its recent private beta program, which attracted more than 1,600 developers since it opened in October 2019.

We see enormous interest in computer vision and how it can drive new value for enterprise applications and developers it makes AI and IoT come alive in the real world, said Marty Beard, co-founder and CEO of alwaysAI. We love evangelizing the value of this exciting new technology, and I believe we are fundamentally changing the way developers create, prototype and deploy computer vision applications at the edge.

Developers, from beginners to experts alike, are encouraged to open their free account at http://www.alwaysai.co and start creating, prototyping and deploying CV apps on ARM-based devices including cameras, drones, wearables, industrial monitoring equipment and transportation units.

Making Development Easy

In the open beta, developers get immediate access to a growing, searchable catalog of pre-trained computer vision models, a full set of CV primitives including image classification, object detection, tracking, counting, face detection and now human pose estimation and semantic segmentation, as well as an expanding array of supported edge environments.

In addition, developers get an open channel of communication with alwaysAIs rapidly growing developer community and direct access to the engineering team.

alwaysAIs accessible and user-friendly platform enables developers to create and deploy computer vision applications in three simple steps:

And with alwaysAI, inferencing happens on the edge, so there is lower latency and no required cloud hosting or inference charges a significant cost and time savings.

Growing Demand from Developers

Co-founders Marty Beard and Steve Griset started alwaysAI with the intention to democratize computer vision and help all enterprise developers leverage CV in practical and affordable ways.

We have seen communications like messaging and speech get automated and proliferated across a wide variety of end-points. But vision arguably the most powerful human attribute has simply been too difficult for technologists to implement and deploy, Beard said. With the open beta program, we are broadening access and offering new features that make it even easier and more powerful for the everyday developer.

Developers from a wide variety of backgrounds and industries agree:

New Computer Vision Features

alwaysAIs computer vision software is now available on NVIDIAs Jetson systems. The combination of alwaysAI's software and NVIDIA's Jetson hardware will provide intelligent sight to devices that run autonomous machines, smart cities, retail services and other advanced computer vision applications.

NVIDIAs Jetson Nano is a small, powerful computer that lets a developer run multiple neural networks in parallel for applications like image classification, object detection, segmentation and speech processing. The Jetson Nano is the ideal platform for creating high-performance deep learning, computer vision projects at the edge.

The alwaysAI platform also makes it easy to build, test and deploy computer vision applications for autonomous driving applications, including a pedestrian and bicyclist detector equipped with semantic segmentation. Autonomous vehicles need to determine how far away pedestrians and bicyclists are, as well as their intentions.

With semantic segmentation, detections are done pixel-by-pixel, rather than with bounding boxes. In certain scenarios like foot and bicycle traffic in bustling urban areas the autonomous vehicle needs much more detailed information about the exact location of a pedestrian or a bicyclist. alwaysAI makes that fast and easy.

In opening up the beta, alwaysAI carefully listened to its growing developer base, offering more of the powerfully optimized tools they want. The alwaysAI platform recently released an easy-to-deploy image for both Raspberry Pi 3B+ and the Raspberry Pi 4. Enterprise software developers and hobbyists alike are tapping into the alwaysAI platform to get their edge computer vision projects up and running.

alwaysAI is an awesome product ... it makes computer vision development on the edge simple, said Tomas Migone, hardware hacker in residence at balena. The tools are easy to use, and the documentation is straightforward. Developing with alwaysAI is a great experience. I'm looking forward to continuing using it for computer vision projects.

For more information about alwaysAI, or to join the companys open beta program, visit http://www.alwaysai.co.

About alwaysAI:

alwaysAI (http://www.alwaysai.co) brings deep learning computer vision to embedded and IoT devices. By providing a professional catalog of pre-trained models, innovative set of computer vision APIs, and growing array of supported edge environments, alwaysAI accelerates the time it takes to get a computer vision app up and running. Based in San Diego, alwaysAI is led by a team of technology veterans who are passionate about democratizing access to computer vision. Co-founders Marty Beard and Steve Griset have more than 40 years of combined experience in enterprise software, mobility, cloud applications and cybersecurity.

Media ContactStephanie CasolaalwaysAI Marketing Manager stephanie.casola@alwaysai.co858-692-6075

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alwaysAI now open to meet growing demand from computer vision developers - PR Web


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