Cheap longevity drug? Researchers aim to test if metformin can slow down aging : Shots – Health News – NPR

Venca-Stastny/Getty Images

Venca-Stastny/Getty Images

A drug taken by millions of people to control diabetes may do more than lower blood sugar.

Research suggests metformin has anti-inflammatory effects that could help protect against common age-related diseases including heart disease, cancer, and cognitive decline.

Scientists who study the biology of aging have designed a clinical study, known as The TAME Trial, to test whether metformin can help prevent these diseases and promote a longer healthspan in healthy, older adults.

Michael Cantor, an attorney, and his wife Shari Cantor, the mayor of West Hartford, Connecticut both take metformin. "I tell all my friends about it," Michael Cantor says. "We all want to live a little longer, high-quality life if we can," he says.

Michael Cantor started on metformin about a decade ago when his weight and blood sugar were creeping up. Shari Cantor began taking metformin during the pandemic after she read that it may help protect against serious infections.

Shari and Michael Cantor both take metformin. They are both in their mid-60s and say they feel healthy and full of energy. Theresa Oberst/Michael Cantor hide caption

Shari and Michael Cantor both take metformin. They are both in their mid-60s and say they feel healthy and full of energy.

The Cantors are in their mid-60s and both say they feel healthy and have lots of energy. Both noticed improvements in their digestive systems feeling more "regular" after they started on the drug,

Metformin costs less than a dollar a day, and depending on insurance, many people pay no out-of-pocket costs for the drug.

"I don't know if metformin increases lifespan in people, but the evidence that exists suggests that it very well might," says Steven Austad, a senior scientific advisor at the American Federation for Aging Research who studies the biology of aging.

Metformin was first used to treat diabetes in the 1950s in France. The drug is a derivative of guanidine, a compound found in Goat's Rue, an herbal medicine long used in Europe.

The FDA approved metformin for the treatment of type 2 diabetes in the U.S. in the 1990s. Since then, researchers have documented several surprises, including a reduced risk of cancer. "That was a bit of a shock," Austad says. A meta-analysis that included data from dozens of studies, found people who took metformin had a lower risk of several types of cancers, including gastrointestinal, urologic and blood cancers.

Austad also points to a British study that found a lower risk of dementia and mild cognitive decline among people with type 2 diabetes taking metformin. In addition, there's research pointing to improved cardiovascular outcomes in people who take metformin including a reduced risk of cardiovascular death.

As promising as this sounds, Austad says most of the evidence is observational, pointing only to an association between metformin and the reduced risk. The evidence stops short of proving cause and effect. Also, it's unknown if the benefits documented in people with diabetes will also reduce the risk of age-related diseases in healthy, older adults.

"That's what we need to figure out," says Steve Kritchevsky, a professor of gerontology at Wake Forest School of Medicine, who is a lead investigator for the Tame Trial.

The goal is to better understand the mechanisms and pathways by which metformin works in the body. For instance, researchers are looking at how the drug may help improve energy in the cells by stimulating autophagy, which is the process of clearing out or recycling damaged bits inside cells.

Researchers also want to know more about how metformin can help reduce inflammation and oxidative stress, which may slow biological aging.

"When there's an excess of oxidative stress, it will damage the cell. And that accumulation of damage is essentially what aging is," Kritchevsky explains.

When the forces that are damaging cells are running faster than the forces that are repairing or replacing cells, that's aging, Kritchevsky says. And it's possible that drugs like metformin could slow this process down.

By targeting the biology of aging, the hope is to prevent or delay multiple diseases, says Dr. Nir Barzilai of Albert Einstein College of Medicine, who leads the effort to get the trial started.

Back in 2015, Austad and a bunch of aging researchers began pushing for a clinical trial.

"A bunch of us went to the FDA to ask them to approve a trial for metformin,' Austad recalls, and the agency was receptive. "If you could help prevent multiple problems at the same time, like we think metformin may do, then that's almost the ultimate in preventative medicine," Austad says.

The aim is to enroll 3,000 people between the ages of 65 and 79 for a six-year trial. But Dr. Barzilai says it's been slow going to get it funded. "The main obstacle with funding this study is that metformin is a generic drug, so no pharmaceutical company is standing to make money," he says.

Barzilai has turned to philanthropists and foundations, and has some pledges. The National Institute on Aging, part of the National Institutes of Health, set aside about $5 million for the research, but that's not enough to pay for the study which is estimated to cost between $45 and $70 million.

The frustration over the lack of funding is that if the trial points to protective effects, millions of people could benefit. "It's something that everybody will be able to afford," Barzilai says.

Currently the FDA doesn't recognize aging as a disease to treat, but the researchers hope this would usher in a paradigm shift from treating each age-related medical condition separately, to treating these conditions together, by targeting aging itself.

For now, metformin is only approved to treat type 2 diabetes in the U.S., but doctors can prescribe it off-label for conditions other than its approved use.

Michael and Shari Cantor's doctors were comfortable prescribing it to them, given the drug's long history of safety and the possible benefits in delaying age-related disease.

"I walk a lot, I hike, and at 65 I have a lot of energy," Michael Cantor says. I feel like the metformin helps," he says. He and Shari say they have not experienced any negative side effects.

Research shows a small percentage of people who take metformin experience GI distress that makes the drug intolerable. And, some people develop a b12 vitamin deficiency. One study found people over the age of 65 who take metformin may have a harder time building new muscle.

"There's some evidence that people who exercise who are on metformin have less gain in muscle mass, says Dr. Eric Verdin, President of the Buck Institute for Research on Aging. That could be a concern for people who are under-muscled.

But Verdin says it may be possible to repurpose metformin in other ways "There are a number of companies that are exploring metformin in combination with other drugs," he says. He points to research underway to combine metformin with a drug called galantamine for the treatment of sarcopenia, which is the medical term for age-related muscle loss. Sarcopenia affects millions of older people, especially women.

The science of testing drugs to target aging is rapidly advancing, and metformin isn't the only medicine that may treat the underlying biology.

"Nobody thinks this is the be all and end all of drugs that target aging," Austad says. He says data from the clinical trial could stimulate investment by the big pharmaceutical companies in this area. "They may come up with much better drugs," he says.

Michael Cantor knows there's no guarantee with metformin. "Maybe it doesn't do what we think it does in terms of longevity, but it's certainly not going to do me any harm," he says.

Cantor's father had his first heart attack at 51. He says he wants to do all he can to prevent disease and live a healthy life, and he thinks Metformin is one tool that may help.

For now, Dr. Barzilai says the metformin clinical trial can get underway when the money comes in.

This story was edited by Jane Greenhalgh

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Cheap longevity drug? Researchers aim to test if metformin can slow down aging : Shots - Health News - NPR

How to Accurately Measure Blood Pressure, According to Dr. Peter … – Men’s Health

Peter Attia, M.D., is a longevity expert and creator of

BLOOD-PRESSURE MANAGEMENT isnt a sexy topic like anti-aging drugs or DNA-based diets, but it has enormous implications for health and life span. And because lifestyle factors have such a profound impact, everyone has the power to take steps toward controlling and improving their BP. Its bread-and-butter primary-care medicinebut a critical part of the longevity playbook.

High blood pressure is a silent killer. There are no symptoms, yet over time the effects of high blood pressure can compound, elevating risk for heart attacks and other serious health concerns, including stroke and dementia. For this reason, managing blood pressure relatively early in life is critical, but many people arent even aware of their BP status. Though nearly half of all adults in the United States have hypertensiondefined as a blood pressure with a systolic reading at or above 130 mm Hg and a diastolic reading at or above 80 mm Hg (see below)only about one in four among this group have their condition under control.

While standard medical wisdom once advised treating to a target of <140/<90, the landmark SPRINT study found that bringing BP down to <120/<80 resulted in huge reductions in the risk of heart attack, stroke, and death from all causes. So when it comes to keeping BP in check, an aggressive approach provides the most benefitsbut where do we begin?

Blood Pressure Categories

NORMAL: < 120 mm Hg (Systolic); < 80 mm Hg (Diastolic)

ELEVATED: 120129 mm Hg (Systolic); < 80 mm Hg (Diastolic)

STAGE 1 HYPERTENSION: 130139 mm Hg (Systolic); 140 mm Hg (Diastolic)

STAGE 2 HYPERTENSION: 8089 mm Hg (Systolic); 90 mm Hg

To manage your BP, you first need to know where youre starting. While a one-time measurement might provide a rough estimate, blood pressure is subject to acute fluctuations based on hydration, stress level, posture, caffeine intake, sleep deprivation, and other variables, so a more accurate picture requires multiple measurements over a span of days. I advise patients to use a home device to check BP twice a day, at the same time each morning and evening, for at least two weeks. The average of those readings will provide a much more accurate reference value than any one-time check. From there, you can monitor changes with weekly or even monthly checks, each time taking one measurement in the morning and one in the evening. The goal in checking frequently is to recognize increases as quickly as possible to facilitate faster intervention.

The gold standard for measuring BP is with a cuff and stethoscope, but this manual method can be intimidating to learn. In my experience, automated cuffs can overestimate BP because they work on an algorithm that estimates systolic and diastolic blood pressure from a measured mean arterial pressure (average BP, essentially), but they are generally good alternatives. Ive used both the Withings (withings.com; BPM Connect, $130) and Omron (amazon.com; M3 model, $80) brand cuffs.

Because so many variables affect BP, its important to follow the same protocol for every measurement:

Sit with your back supported for five minutes before measuring. (This can feel like a long time, since you should not be looking at your phone or speaking.)

Do not cross your legs.

Check that the cuff is against your skin and fits well.

Avoid talking during the check.

Note: Having a full bladder can bump up your BP by 10 to 15 mm Hg.

This story appears in the November 2023 issue of Men's Health.

Author

Peter Attia, MD, is the author of the New York Times Bestseller, Outlive: The Science and Art of Longevity and is host of the popular health and medicine podcast, The Drive. He received his medical degree from the Stanford University School of Medicine and trained at the Johns Hopkins Hospital in general surgery. Hes the founder of Early Medical, a medical practice that helps patients lengthen their lifespan and simultaneously improve their healthspan.

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How to Accurately Measure Blood Pressure, According to Dr. Peter ... - Men's Health

China-Thailand Medical Exchange Strengthens Bilateral Cooperation – Bangkok Post

A successful medical exchange event between China and Thailand has strengthened bilateral cooperation in the healthcare sector, with a focus on cutting-edge topics like regenerative medicine and anti-aging.

PUBLISHED : 23 Nov 2023 at 10:35

The China-Thailand Medical Exchange Meeting, jointly organised by Bloomage BioTechnology, Thailand's BCH Group, Lavida Medical Consultant Company, World Medical Hospital, and Thailand's Fanslink Company, was successfully conducted at World Medical Hospital in Thailand. This event signifies not only a significant occurrence in the medical sector but also a crucial milestone in medical cooperation and exchange between China and Thailand.

On the morning of November 22, 2023, over 70 deans and doctors from major Chinese cities received a warm welcome at World Medical Hospital in Bangkok, complete with traditional Thai ceremonies. They explored various departments of the hospital, with particular attention to anti-aging and reproduction units, and participated in a Sino-Thai medical exchange meeting at the same venue. The highlight of the event was a comprehensive showcase of Thailand's international medical expertise, highlighting the nation's leadership in these fields.

The primary focus of the exchange meeting was to enhance cooperation and exchange in the medical field between China and Thailand. At the beginning of the conference, Mr. Wissanu Krea-ngam, former Deputy Prime Minister of Thailand, delivered a video message emphasising the importance of medical cooperation between China and Thailand, sharing his experiences of multiple visits to China for cooperation. Furthermore, senior leaders from BCH Group, Lavida Medical, and World Medical Hospital also delivered speeches, further underlining the profound significance of medical exchanges between China and Thailand.

A special mention must be made of the outstanding speeches delivered by representatives of Lavida Medical, including Dr. Porntip, Dr. LIM WEI KHOON, and Ms. Jiang Bowen. They not only introduced the latest developments in Thai medical care to the Chinese delegation but also engaged in in-depth discussions on cutting-edge topics such as regenerative medicine and anti-aging. The Q&A session that followed was the climax of the meeting, during which both sides engaged in extensive discussions on cutting-edge anti-aging therapies and medications, medical instruments, international medical standards, and certifications, among other topics. The meeting atmosphere was warm, and the exchanges were fruitful.

The success of this exchange meeting has not only deepened the understanding and friendship between China and Thailand in the medical field but has also laid a solid foundation for future cooperation and development. After the meeting, Bloomage BioTechnology, Thailand BCH Group, and Lavida Medical exchanged gifts and took group photos, symbolising the promising future and strong friendship of China-Thailand medical cooperation. With the continued organisation of such exchange activities, we have reason to believe that cooperation between China and Thailand in the healthcare sector will flourish and benefit the people of both countries.

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China-Thailand Medical Exchange Strengthens Bilateral Cooperation - Bangkok Post

Medical Aesthetics Market Size Worth USD 43.2 Billion in 2032 … – GlobeNewswire

Vancouver, Nov. 22, 2023 (GLOBE NEWSWIRE) -- The global medical aesthetics market size was USD 15.3 Billion in 2022 and is expected to register rapid revenue CAGR of 11.0% during the forecast period. Key factors propelling this growth include the increasing awareness of aesthetic procedures, a surge in the adoption of minimally invasive devices, a rising demand for home-based aesthetic procedures, and continuous technological advancements in aesthetic devices.

Minimally invasive and non-surgical aesthetic treatments are gaining popularity, offering practical and risk-free alternatives to traditional surgery. Procedures such as Botox, dermal fillers, laser therapy, chemical peels, and microdermabrasion are on the rise due to their minimal downtime, making them optimal for quick recovery and the resumption of routine activities. The total number of non-surgical cosmetic operations increased by 44% in 2021 compared to surgical cosmetic procedures, with a substantial growth of 63% in the body procedures category. This trend is driven by accessibility, adaptability, and reduced scarring concerns associated with non-surgical treatments.

The rising demand for home-based cosmetic procedures is a significant driver, fueled by the increasing prevalence of dermatological diseases like acne, psoriasis, and skin cancer. However, poor reimbursement conditions pose a restraint to market growth, as cosmetic procedures, equipment, and devices are often not covered by insurance providers. Recent trends include the growth of medical aesthetics tourism, the destigmatization of aesthetic procedures, and the use of the internet to find the best providers.

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The facial aesthetic product segment led the market in 2022, driven by the increasing number of individuals seeking a youthful appearance and disposable financial resources. Notably, Allergan Aesthetics introduced the SkinMedica Even & Correct Collection, focusing on lightening treatments and dark-spot reduction creams. The cosmetic implant segment is expected to experience moderate growth due to clear regulatory requirements, the acceptance of bio-implants, and an increase in target diseases. Noteworthy approvals include Allergan's NATRELLE INSPIRA Soft Touch breast implants and Sientra Inc.'s gel breast implants.

The non-surgical procedures segment is anticipated to hold a significant revenue share, driven by the increasing popularity of lipolysis. Technological advancements, product introductions like Lumenis Ltd.'s NuEra Tight, and growing awareness among the elderly contribute to this segment's growth. Hospitals and clinics are expected to register fast revenue growth, driven by automated systems, early disease diagnosis, and the digitization of patient workflows. Beauty centers and medical spas, offering non-invasive skin rejuvenation procedures, are projected to account for the largest revenue share.

North America dominated the market in 2022, driven by experienced cosmetic surgeons, increased adoption of cosmetic operations, and advanced healthcare infrastructure. The Cleveland Clinic Organization estimates over 15 million cosmetic surgery treatments annually in the U.S.

The Asia Pacific region is poised for the fastest revenue growth, attributed to rising awareness of anti-aging surgeries, medical tourism, improved healthcare infrastructure, and affordable treatment costs. Government policies promoting cosmetic medicine standardization contribute to market growth.

Europe is expected to account for a substantial revenue share, driven by the demand for high-quality aesthetic procedures, established healthcare infrastructure, and an effective reimbursement system. The rising number of aesthetic operations is also a contributing factor. The global medical aesthetics market is experiencing significant growth driven by a shift towards minimally invasive treatments, increasing demand for home-based procedures, and ongoing technological advancements. Market players are responding with innovative products, contributing to the expansion of the industry.

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Medical Aesthetics Report Summary

Medical Aesthetics Top Companies and Competitive Landscape

The global medical aesthetic market is fairly fragmented with many large and medium-sized players accounting for majority of market revenue. Major players are deploying various strategies, entering into mergers & acquisitions, strategic agreements & contracts, developing, testing, and introducing more effective medical aesthetic solutions. Some major players included in the global medical aesthetic market report are:

Medical Aesthetics Latest Industry News

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Medical Aesthetics Market Segment Analysis

For the purpose of this report, Emergen Research has segmented global medical aesthetic market on the basis of product, procedure, end-use, and region:

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Medical Aesthetics Market Size Worth USD 43.2 Billion in 2032 ... - GlobeNewswire

Parathyroid hormone stimulates bone regeneration in an atrophic … – Journal of Translational Medicine

Animals

A total number of 34 male and female CD-1 mice with a body weight of 3545g and an age of 1820 months were used. The age of 1820 months was chosen according to reports of others, demonstrating age-associated physiological alterations and tumor development after 1618 months in male and 18 months in female CD-1 mice [16]. The animals were bred at the Institute for Clinical and Experimental Surgery, Saarland University, Germany, and housed at a regular light and dark cycle with free access to tap water and standard pellet food (Altromin, Lage, Germany).

All experiments were performed according to the German legislation on the protection of animals and the National Institutes of Health (NIH) Guide for the Care and Use of Laboratory Animals (Institute of Laboratory Animal Resources, National Research Council, Washington DC, USA). The experiments were approved by the local governmental animal protection committee (permit number: 04/2019).

Mice were anesthetized by intraperitoneal (i.p.) injection of ketamine (75mg/kg body weight, Ursotamin, Serumwerke Bernburg, Bernburg, Germany) and xylazine (15mg/kg body weight, Rompun, Bayer, Leverkusen, Germany). The pin-clip model using a segmental defect served as control and was performed as described previously [15]. Under aseptic conditions, a ~4mm medial parapatellar incision was created at the right knee and the patella was dislocated laterally. After drilling a hole (diameter of 0.50mm) into the intracondylar notch, a distally flattened pressfit 24 Gauge needle (diameter of 0.55mm) was implanted intramedullary and the wound was closed. The pin was flattened at the distal end to avoid secondary dislocation. After insertion of the pin, the diaphysis of the femur was exposed by a lateral approach. Subsequently, a custom-made clip of 6mm length was implanted ventrodorsally into the femur and lateral of the already implanted pin. A gap size of 1.8mm was created by means of a spherical trephine under permanent saline solution cooling. Moreover, the periosteum was stripped 2mm proximally and distally of the gap along the longitudinal axis of the femoral bone. The implant position was confirmed by radiography (MX-20, Faxitron X-ray Corporation, Wheelin, IL, USA). All procedures were done under an operating microscope, guaranteeing a high level of precision. For analgesia the mice received tramadol-hydrochloride (Grnenthal, Aachen, Germany) in the drinking water (1mg/mL) 1 day prior to surgery until 3 days after surgery.

Seventeen mice were daily treated with 200mg/kg body weight PTH 134 (Bachem AG, Budendorf, Switzerland) dissolved in 100 L saline, subcutaneously (PTH group). Control animals (n=17) received an equal amount of saline (control group), subcutaneously. The used PTH dosage corresponds to other experimental studies investigating the effects of PTH on fracture healing in mice [13]. At 2 weeks [n=5 each group (3 male; 2 female)] and 10 weeks [n=9 each group (5 male; 4 female)] the animals were euthanized by an overdose of anesthetics and the femora were excised for further CT and histological analyses. Additional animals were euthanized accordingly at 2 weeks [n=3 each group (2 male; 1 female)] and tissue was harvested for Western blot analyses.

At 2 and 10 weeks after surgery the animals were anesthetized and lateral radiographs of the osteotomized femora were performed. Bone healing was analyzed according to the Goldberg score with stage 0 indicating radiological non-union, stage 1 indicating possible union and stage 2 indicating radiological union [17].

The specimens were scanned (Skyscan 1176, Bruker, Billerica, MA) at a spatial resolution of 9m with a standardized setup (tube voltage: 50kV; current: 200 A; intervals: 0.4; exposure time: 3500 ms; filter: 0.5mm aluminum). Images were stored in three-dimensional arrays. To express gray values as mineral content (bone mineral density; BMD), calcium hydroxyapatite (CaHA) phantom rods with known BMD values (0.250 and 0.750g CaHA/cm3) were employed for calibration. The region of interest (ROI) defining the novel bone was contoured manually excluding any original cortical bone. The thresholding allowed the differentiation between poorly and highly mineralized bone. The threshold to distinguish between poorly and highly mineralized bone was based upon visual inspection of the images, qualitative comparison with histological sections and other studies investigating bone repair and callus tissue by CT [18, 19]. A BMD with more than 0.642g/cm3, resulting in gray values of 98255, was defined as highly mineralized bone. Poorly mineralized bone was assumed to have a BMD value between 0.410g/cm3 and 0.642g/cm3, resulting in gray values of 6897.

The following parameters were calculated from the callus region of interest for each specimen: poorly mineralized bone volume (PM), highly mineralized bone volume (HM), bone volume fraction of tissue volume (BV/TV), bone surface (BS) density (BS/TV), trabecular thickness, trabecular separation and trabecular number.

After removal of the soft tissue and the implants, the bending stiffness of the isolated femora was measured by a 3-point-bending device using a non-destructive approach. This allowed the subsequent use of the specimens for CT as well as histological and immunohistochemical analyses and, thus, a reduction of the number of laboratory animals. Due to the different stages of healing, the loads, which had to be applied, markedly varied between individual animals. Loading was stopped individually in every case when the actual load-displacement curve deviated more than 1% from linearity. Bending stiffness (N/mm) was calculated from the linear elastic part of the load-displacement diagram [20].

After biomechanical testing and CT analysis, bones were fixed in paraformaldehyde for 24h. Subsequently, the specimens were embedded in a 30% sucrose solution for another 24h and then frozen at 80 C. Longitudinal sections through the femoral axis with a thickness of 4m were cut by the Kawamotos film method [21, 22] for histomorphometric analyses and stained with Safranin-O. At a magnification of 12.5 (Olympus BX60 Microscope, Olympus, Shinjuku, Japan; Zeiss Axio Cam and Axio Vision 3.1, Zeiss) structural indices were calculated according to the recommendations of Gerstenfeld et al. [23]. The following histomorphometric parameters of the bone defects were evaluated: (i) total callus area, (ii) bone callus area, (iii) cartilaginous callus area and (iv) fibrous callus area. The total callus area was defined as the entire osseous, cartilaginous and fibrous callus tissue between the two drilling holes of the clip outside of the cortices. Pre-existing cortical bone of the proximal and distal fragment, however, was excluded. Each area was marked and calculated using the ImageJ analysis system (NIH, Bethesda, USA).

In addition, tartrate-resistant acid phosphate (TRAP) activity was analyzed in the callus tissue at 2 and 10 weeks after surgery. For this purpose, longitudinal sections of 4m were incubated in a mixture of 5mg naphotol AS-MX phosphate and 11mg fast red TR salt in 10 mL 0.2M sodium acetate buffer (pH 5.0) for 1h at 37C. Sections were counterstained with methyl green and covered with glycerin gelatin. TRAP-positive multinucleated cells (three or more nuclei each cell) were counted. In the specimens, one high-power field (HPF, 400 magnification) was placed in a standardized manner in the central region of the callus, while three additional HPFs were placed on each site of the periosteal callus.

To analyze the cellular composition within the callus tissue of atrophic non-unions at 2 and 10 weeks after surgery, longitudinal sections with a thickness of 4m were cut. For the immunohistochemical detection of microvessels, sections were stained with a monoclonal rat anti-mouse antibody against the endothelial cell marker CD31 (1:100; Abcam, Cambridge, UK). A goat anti-rat IgG-Alexa555 antibody served as secondary antibody (1:100; Life Technology, Eugene, USA). Cell nuclei were stained with Hoechst 33342 (2g/mL; Sigma-Aldrich, Taufkirchen Germany). To detect the neutrophilic granulocyte marker myeloperoxidase (MPO) and the macrophage marker CD68, sections were stained with a polyclonal rabbit anti-mouse antibody against MPO (1:100; Abcam) and a polyclonal rabbit anti-mouse antibody against CD68 (1:100; Abcam). A goat anti-rabbit IgG-antibody (1:200; Dianova, Hamburg, Germany) served as corresponding secondary antibody.

In the specimens, the number of CD31-positive microvessels as well as MPO- and CD68-positive cells was counted. For this purpose, one HPF was placed in a standardized manner in the central region of the callus, while three additional HPFs were placed on each site of the periosteal callus.

Protein expression within the callus tissue was determined by Western blot analysis, including the expression of vascular endothelial growth factor (VEGF), cyclooxygenase (COX)-2 and phosphoinositide 3-kinase (PI3K). The callus tissue was frozen and stored at 80C until required. Analyses were performed from callus tissue at 2 weeks after surgery (n=3 each group). After saving the whole protein fraction, analysis was performed using the following antibodies: rabbit anti-mouse VEGF (1:300, Abcam, Cambridge, UK), COX-2 (1:30, Abcam) and mouse anti-mouse PI3K (1:100, Santa Cruz Biotechnology, Heidelberg, Germany). Primary antibodies were followed by corresponding horseradish peroxidase-conjugated secondary antibodies (1:1000, R&D Systems). Protein expression was visualized by means of luminol-enhanced chemiluminescence after exposure of the membrane to the Intas ECL Chemocam Imager (Intas Science Imaging Instrument GmbH, Gttingen, Germany) and normalized to -actin signals (1:1000, mouse anti-mouse -actin, Santa Cruz Biotechnology) to correct for unequal loading.

All data are given as meansSEM. After testing the data for normal distribution (KolmogorovSmirnov test) and equal variance (F-test), comparisons between the two groups were performed by an unpaired Students ttest. For nonparametrical data, a MannWhitney Utest was used. All statistics were performed using the SigmaPlot 13.0 software (Jandel Corporation, San Rafael, CA, USA). A pvalue of <0.05 was considered to indicate significant differences.

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Parathyroid hormone stimulates bone regeneration in an atrophic ... - Journal of Translational Medicine

These Luxury Brands Use Flowers in Their Skincare Products … – Thursd

Chanel's research uncovered the benefits of red camellia extract from the Camellia Japonica 'Czar' species. The odorless flower has an enduring quality, as evidenced by petals that are unaffected by water or cold. They are hand-picked at full turgescency and contain protocatechuic acid, a powerful and nutritive molecule not found in the previous camellias studied. This species, in particular, has a remarkable ability to support skin vitality, which has been translated into the No.1 De Chanel range, which addresses the first stage of skin aging. Its antioxidant content rejuvenates and keeps skin looking young.

The formulas in the collection contain up to 97% natural and renewable ingredients, with camellia derivatives accounting for 75% of the total. To reduce waste, various plant parts are used in the formula and packaging. The extract is used for its rejuvenating properties, while the camellia water soothes. The oil obtained by pressing the seeds keeps the complexion moist, while the seed shells are used in the packaging of the 'Revitalizing Cream'.

The range comprises nine products, including the new Powder-To-Foam cleanser that becomes creamy upon contact with water. Other skincare products include a pore-tightening lotion, a revitalizing serum, a smoothening cream, and an accompanying eye cream to target dark circles and puffiness. As for makeup, red camellia oil is infused into the hydrating foundation, and lip and cheek balm. The Lau Rouge Revitalizing Fragrance Mist keeps skin fresh all day while also functioning as a fragrance. The camellia is odorless, but its scent is reimagined as a floral bouquet of jasmine, orange blossom, and rose. An exquisite skincare and makeup line with the benefits of the camellia flower! PS: the camellia is also Chanel's fashion emblem.

The luxurious Guerlain Orchide Impriale Cream, a cult beauty elixir for over 15 years, is synonymous with the most advanced orchid skincare research.s. Endowed with extraordinary longevity, these blooms provide potent cosmetic anti-aging properties. Guerlain's Orchidarium's most recent research has discovered the secret of infinite longevity, which was discovered in the deepest roots of an extraordinary duo of orchids chosen from over 30,000 species.

The first is Gastrodia Elata, a legendary herb used in Traditional Chinese Medicine that grows in the mountains of Yunnan and other parts of China. Aside from its exceptional regenerating properties, a precious fraction extracted from its roots has been found to immediately combat a lack of cell oxygen and to protect skin cells. The second is the Dendrobium Fimbriatum, which lives on the surface of tree trunks or branches and has a remarkable ability to survive. Its extraordinary aerial roots, in particular, synthesize a wide range of molecules.

The regenerative power of both orchid roots has now been concentrated in the cutting-edge Orchid Totum technology. This molecular extract, which is made up of many different molecules, helps to regulate cell respiration, fight hypoxia, and, for the first time, targets a longevity enzyme, PHD3, which can dramatically reverse the visible signs of aging. Guerlain collaborated with the prestigious Swiss Federal Institute of Technology in Zurich to discover the enzyme.

Aside from the Orchid Totum, the Guerlain Orchide Impriale Cream 2022 has an exceptional sensory feel infused into a formula made up of 96% naturally derived ingredients. The cream is ultra-fine, soft and emollient, rich and plumping, and provides all-day hydration. After seven days of use, study subjects aged 18 to 72 had skin that appeared three years younger, based on a comparison of dermis density using approximately 6,000 skin ultrasounds. Dermatologists' clinical evaluations also revealed a significant improvement in the visible signs of aging, ranging from increased radiance to wrinkle reduction to increased hydration.

Cl de Peau Beaut's Synactif collection, inspired by detoxifying spa treatments and backed by cutting-edge science, was launched in 2004 and sits at the pinnacle of the luxury Japanese beauty brand's offerings. It targets the skin's natural impurity removal processes and supports the skin's self-beautifying system for youthful, radiant, sculpted beauty.

Synactif is a complete and holistic regimen that provides a combination of efficacy and experience, the latter of which is enhanced in part by a key ingredient: the Synactif Rose. It was first commissioned by France's renowned Delbard nursery in search of a fragrance that would embody the relaxing, harmonious, and purifying qualities of the Synactif line.

So perfect was the result that the rose won the Best Fragrance Award at the Bagatelle International Rose Competition. The fragrance is inspired by the moment the flower blooms, releasing its precious scent for a mere few hours in the mornings of May. It was then incorporated into each step of the Synactif regimen to offer the ultimate sensorial experience.

The longoza flower, grown in the Maison's garden in the heart of the Indian Ocean, is the secret behind Dior's Capture Totale collection. Madagascar is home to a biodiverse ecosystem with 13,500 endemic flowers, 75 percent of which are not found anywhere else.

A Dior garden in the Ranomafana area of the rainforest combines traditional hand-harvesting with a rigorous extraction method. The house has been researching the legendary longoza for 30 years. The scarlet flower, which means 'eternal' in Madagascan, never dies and regenerates when cut, earning it the nickname 'Phoenix flower'.The longoza can resurrect itself in the harshest of environments. As a skincare extract, it has a powerful regenerative quality in the face of cellular fatigue - a condition in which cells struggle to renew and absorb nutrients, leaving the complexion vulnerable to visible signs of aging. The extract helps the skin's mother cells by resetting them with powerful nutrients to restore the complexion's radiance.

This year, after five years of research, Dior unveils its breakthrough development of the Longoza-Ferments Blend a first in the Capture Totale range. The biotechnology solution is created through a 10-step flash multi-fermentation process, during which the flower is put into contact with 10 ferments for 10 days. In its natural state, longoza seeds contain 50 active molecules. This innovation maximizes their active molecular content, triggering optimal efficacy and ability to be absorbed by the skin.

The newly launched Capture Totale Intensive Essence Lotion contains a 75 percent infusion of this potent blend. This high concentration helps the skin cells to achieve the houses pillars of skin quality including clearness, moisture, and strength. With daily application in the morning, the skin is reset for the day. Plumpness and radiance are restored, while signs of fatigue and stress are visibly reduced.

The rose may be the worlds most well-known and adored flower. A symbolic flower in so many moments of life, its also a primary part of Lancmes heritage as a beauty brand. The first rose was created for Lancme in 1973 and is known for its exceptional color and long-lasting blooms. It was the first rose used in biotechnology for skincare. Now, 37 years later we feature a new variation of the precious flower at Lancme with the Absolue Perpetual Rose.

Lancme's International Scientific Director, Dr. Annie Black, explained what the composition is of the Absolue Perpetual Rose extract and why is it unique compared to other roses. According to Dr. Black, the unique terroir of the Plateau de Valensole contributes to the one-of-a-kind potential of this rose. Part of the Verdon Natural Park, near the Gorges du Verdon and its lakes in the Alpes-de-Haute-Provence, the privileged location benefits from a climate that is half-Mediterranean and half-Alpine and allows for exceptional quality roses to be grown on the Plateau. The beautiful rose fields of the Plateau de Valensole are carefully overseen by third-generation farmer, Madame Emmanuelle Ravel, who ensures each rose receives the love and care it deserves. The exquisite rose fields contain over 5,000 different rose bushes which bloom on three acres of land and are grown according to organic farming principles.

The Absolue Perpetual Rose is organically grown and special care and consideration are in place for the extraction process. Hand harvested in the early morning when the flowers start to bloom, the roses are swiftly brought to the nearby factory for extraction. The secret is to waste as little time as possible between the harvest in the fields and the extraction process. It is extracted for its use in skincare uniquely and sustainably, captured through a unique green technology process that enables upcycling of ingredients that were previously discarded for use in the company's skincare formulas. In this process, CO2 is leveraged to extract the exclusive rose molecules while producing minimal rose bio-waste.

Grand Rose Extracts is Lancmes Proprietary Blend of rose extracts sourced exclusively from the South of France and is infused in their Absolute Skin Surface Cell Renewing Serum. In this formulation, the Absolue Perpetual Rose is paired with Rose Centifolia extract, also known as Rosewood, an ingredient that was usually discarded during extraction, but is now upcycled and used for the first time as an antioxidant.

It's amazing to see how flowers are being used more and more for different purposes. If you're keen to hype up your skincare routine, these might be the next products you're looking for.

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These Luxury Brands Use Flowers in Their Skincare Products ... - Thursd

Lucuma Is The Maple-Caramel Superfood Of Our Dreams And It’s Great for Diabetics! – Yahoo Life

Imagine a fruit that looks eerily similar to a ripe avocado and has similar health benefits but it leaves your mouth tasting of maple syrup. That fruit does exist, and it may be the most powerful superfood you've never heard of. Lucuma is a delicious fruit native to South America that's been gaining attention stateside for years and it's only becoming more popular. While it may be difficult to find the fresh fruit in US supermarkets, lucuma powder boasts similar benefits. But what is lucuma powder and how can it enhance your health? Read on to learn what nutrition experts say about lucuma powder benefits.

Lucuma (pronounced loo-koo-ma) is a fleshy fruit from the Pouteria lucuma tree, which is native to the Andes Mountain regions of South America. It has a unique, sweet flavor that is often compared to maple, caramel, sweet potato and butterscotch. The powerful health benefits gained it the nickname "Gold of the Incas" in ancient Peru. (Click through to learn about another South American superfood, acai.) And its still an important flavor in Peru, notes Manuel Villacorta MS, RD, founder and owner of MV Nutrition and author of Peruvian Power Foods. We usually use lucuma for desserts because of its maple flavor, he says, noting that lucuma-flavored ice cream is often considered the national dessert of Peru.

But the delicate fruit ripens quickly, making it difficult to import to the United States, explains Villacorta. That's why you'll seldom find the bright yellow fruit in your average supermarket. The next best option? Lucuma powder, which is often frozen at the peak of freshness to preserve nutrients and then made into a powder. Plus, it can be used as a replacement for sugar with about half the carbs and 75% less sugar. One to try: Terrasoul Superfoods Organic Lucuma Powder (Buy from Amazon, $14.99).

Lucuma powder is a good alternative to using natural sugar, says Villacorta. Why? Lucuma powder has a far lower glycemic impact than sugar. That means the sweetener is far less likely to spike blood sugar, thanks to more complex carbohydrates like fiber and fewer simple carbohydrates like sugar in the powder. Whats more, research in the Journal of Food Medicine revealed the fruit can lower levels of carbohydrate-digesting enzymes to further ward off sugar swings. (Click through for a list of more low-glycemic fruits.)

But thats not just a benefit for diabetics. Better blood sugar control can help any woman feel more energized and reduce appetite, regardless of if you have the condition or not. Indeed, studies show fatigue can drop as much as 90% and weight loss can speed up by 42% when blood sugar is balanced.

Related: Glucose Goddess: 4 Brilliant Hacks That Dramatically Improve Blood Sugar

Lucuma powder is also rich in gut-healthy fiber that help the body better process carbohydrates. Fiber is very beneficial for glucose metabolism, confirms Villacorta. Indeed, studies show that increasing fiber intake can notably lower your risk of developing diabetes. A tablespoon of lucuma has about 2 grams of fiber. While that may not sound like much, thats significantly more of the nutrient than you'll find in sugar and other alternative sweeteners. Plus, Villacorta adds that you may need more than just a tablespoon. Ive used about half a cup to get the right taste of sweetness, he says. Not only will you get more delicious flavor, but youll also get an extra punch of lucuma powders healthful nutrients!

Related: Top Doctor: *This* Sweetener Dials Down Blood Sugar to Make Weight Loss Effortless

Lucuma brims with health nutrients, antioxidants and minerals that can be a major boon for your overall health. Keep reading to discover what else this superfood can do for your health.

When estrogen drops during menopause, we tend to accumulate more belly fat. The hormone helps to regulate metabolism and reduce inflammation. So when our levels of estrogen dip, were more likely to accumulate fat, especially in the midsection. The microbiome is also affected when women go through menopause, adds Villacorta. Research in the International Journal of Womens Health confirms that when we reach menopause, we have less diversity of healthy bugs in our guts. But Villacorta says the prebiotic fiber in lucuma can mitigate that, helping to increase microbiome diversity and ease fat-packing inflammation. (Click through to learn how green smoothies can help melt menopausal belly fat.)

Inflammation-taming antioxidants in lucuma are key for preventing chronic illnesses like heart disease, notes Villacorta. One of those key antioxidants: beta-carotene, the pigment that gives the fruits flesh its bright orange color and is also found in carrots and sweet potatoes. Harvard University research suggests that increasing levels of beta carotene can slash stroke risk, while a study in the American Journal of Public Health asserts the nutrient can protect against heart disease. (Click through for more on the health benefits of sweet potatoes.)

The heart-healthy benefits dont end there. Research published in the Journal of Medicinal Food found the fruit works similar to anti-hypertensive drugs like ACE inhibitors. They found that lucuma can lead to notable reductions in blood pressure by reducing the activity of an enzyme called alpha-glucosidase (ACE). In high concentrations, this enzyme narrows blood vessels to drive up blood pressure.

Your eyes can benefit from lucuma powder, since it contains anthophylls, a group of plant nutrients that includes the vision-protecting nutrients lutein and zeaxanthin. According to scientists from the University of Wisconsin, getting a daily dose of these vitamins can lower your risk of age-related macular degeneration (AMD) by 46%. (Click through for other nutrients that may prevent macular degeneration.)

When it comes making your skin look younger and healthier, lucuma powder is a good choice. Credit goes to antioxidants like vitamin C, calcium, potassium and other phytonutrients found in the fruit, which are essential for skin health. Indeed, research from Rutgers University revealed that lucuma boosted skin regeneration and boasts anti-aging properties.

What's more, the beta-carotene in lucuma helps with skin health, says Villacorta. Boosting your levels of this healthful nutrients can protect your skin against UV damage, according to researchers from the University of Arizona. Beta-carotene also has antioxidant properties that reduce free radicals damaging compounds that can speed up skin aging.

Our immune systems rely on a variety of nutrients to power virus-fighting white blood cells and keep us cold- and flu-free. Thankfully, the high content of phytonutrients and bioactive compounds in lucuma support the immune system, says Villacorta. For instance, its immune-boosting vitamin C may reduce the severity and duration of colds, and its calcium and potassium act as electrolytes that reduce inflammation that can make illness worse and encourage virus-fighting T-cell activity. (Click though to learn about another immunity-booster, star anise.)

Nutrients like beta-carotene and B vitamins are key for warding off memory blips. Thankfully, you can get a dose from lucuma to help nourish the brain. In fact, researchers in Cochrane Reviews say keeping levels of these vitamins in a healthy range may stave off memory loss for years to come.

Related: The 7 Best Ways To Reverse Brain Aging & Strengthen Memory, According to Scientists

Lucuma is a versatile sweetener that can replace sugar in any recipe and add a touchy of maple flavor, though it is less sweet than sugar. Villacorta likes using it to make ice cream, smoothies and even in cheesecake! While It can be used to sweeten foods, lucuma powder is not as sweet as sugar and should be doubled in recipes if replacing sugar, explains nutritionist Vanessa King, RDN. Or you can use lucuma in combination with sugar to give more flavor to food with less sugar. (Click through for 3 delicious smoothie recipes using lucuma.) Sprinkling the powder over yogurt or oatmeal or blending it into coffee drinks are other popular uses. But regardless of how you enjoy the superfood, don't skip out on the powerful benefits of lucuma powder!

This content is not a substitute for professional medical advice or diagnosis. Always consult your physician before pursuing any treatment plan.

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Lucuma Is The Maple-Caramel Superfood Of Our Dreams And It's Great for Diabetics! - Yahoo Life

Nutrient found in beef and dairy improves immune response to cancer – EurekAlert

Trans-vaccenic acid (TVA), a long-chain fatty acid found in meat and dairy products from grazing animals such as cows and sheep, improves the ability of CD8+ T cells to infiltrate tumors and kill cancer cells, according to a new study by researchers from the University of Chicago.

The research, published this week in Nature, also shows that patients with higher levels of TVA circulating in the blood responded better to immunotherapy, suggesting that it could have potential as a nutritional supplement to complement clinical treatments for cancer.

There are many studies trying to decipher the link between diet and human health, and its very difficult to understand the underlying mechanisms because of the wide variety of foods people eat. But if we focus on just the nutrients and metabolites derived from food, we begin to see how they influence physiology and pathology, said Jing Chen, PhD, the Janet Davison Rowley Distinguished Service Professor of Medicine at UChicago and one of the senior authors of the new study. By focusing on nutrients that can activate T cell responses, we found one that actually enhances anti-tumor immunity by activating an important immune pathway.

Finding nutrients that activate immune cells

Chens lab focuses on understanding how metabolites, nutrients and other molecules circulating in the blood influence the development of cancer and response to cancer treatments. For the new study, two postdoctoral fellows, Hao Fan, PhD and Siyuan Xia, PhD, both co-first authors, started with a database of around 700 known metabolites that come from food and assembled a blood nutrient compound library consisting of 235 bioactive molecules derived from nutrients. They screened the compounds in this new library for their ability to influence anti-tumor immunity by activating CD8+ T cells, a group of immune cells critical for killing cancerous or virally infected cells.

After the scientists evaluated the top six candidates in both human and mouse cells, they saw that TVA performed the best. TVA is the most abundant trans fatty acid present in human milk, but the body cannot produce it on its own. Only about 20% of TVA is broken down into other byproducts, leaving 80% circulating in the blood. That means there must be something else it does, so we started working on it more, Chen said.

The researchers then conducted a series of experiments with cells and mouse models of diverse tumor types. Feeding mice a diet enriched with TVA significantly reduced the tumor growth potential of melanoma and colon cancer cells compared to mice fed a control diet. The TVA diet also enhanced the ability of CD8+ T cells to infiltrate tumors.

The team also performed a series of molecular and genetic analyses to understand how TVA was affecting the T cells. These included a new technique for monitoring transcription of single-stranded DNA called kethoxal-assisted single-stranded DNA sequencing, or KAS-seq, developed by Chuan He, PhD, the John T. Wilson Distinguished Service Professor of Chemistry at UChicago and another senior author of the study. These additional assays, done by both the Chen and He labs, showed that TVA inactivates a receptor on the cell surface called GPR43 which is usually activated by short-chain fatty acids often produced by gut microbiota. TVA overpowers these short-chain fatty acids and activates a cellular signaling process known as the CREB pathway, which is involved in a variety of functions including cellular growth, survival, and differentiation. The team also showed that mouse models where the GPR43 receptor was exclusively removed from CD8+ T cells also lacked their improved tumor fighting ability.

Finally, the team also worked with Justin Kline, MD, Professor of Medicine at UChicago, to analyze blood samples taken from patients undergoing CAR-T cell immunotherapy treatment for lymphoma. They saw that patients with higher levels of TVA tended to respond to treatment better than those with lower levels. They also tested cell lines from leukemia by working with Wendy Stock, MD, the Anjuli Seth Nayak Professor of Medicine, and saw that TVA enhanced the ability of an immunotherapy drug to kill leukemia cells.

Focus on the nutrients, not the food

The study suggests that TVA could be used as a dietary supplement to help various T cell-based cancer treatments, although Chen points out that it is important to determine the optimized amount of the nutrient itself, not the food source. There is a growing body of evidence about the detrimental health effects of consuming too much red meat and dairy, so this study shouldnt be taken as an excuse to eat more cheeseburgers and pizza; rather, it indicates that nutrient supplements such as TVA could be used to promote T cell activity. Chen thinks there may be other nutrients that can do the same.

There is early data showing that other fatty acids from plants signal through a similar receptor, so we believe there is a high possibility that nutrients from plants can do the same thing by activating the CREB pathway as well, he said.

The new research also highlights the promise of this metabolomic approach to understanding how the building blocks of diet affect our health. Chen said his team hopes to build a comprehensive library of nutrients circulating in the blood to understand their impact on immunity and other biological processes like aging.

After millions of years of evolution, there are only a couple hundred metabolites derived from food that end up circulating in the blood, so that means they could have some importance in our biology, Chen said. To see that a single nutrient like TVA has a very targeted mechanism on a targeted immune cell type, with a very profound physiological response at the whole organism levelI find that really amazing and intriguing.

The study, Trans-vaccenic acid reprograms CD8+ T cells and anti-tumor immunity, was supported by the National Institutes of Health (grants CA140515, CA174786, CA276568, 1375 HG006827, K99ES034084), a UChicago Biological Sciences Division Pilot Project Award, the Ludwig Center at UChicago, the Sigal Fellowship in Immuno-oncology, the Margaret E. Early Medical Research Trust, the AASLD Foundation a Harborview Foundation Gift Fund, and the Howard Hughes Medical Institute.

Experimental study

Animals

Trans-vaccenic acid reprograms CD8+ T cells and anti-tumor immunity

22-Nov-2023

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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Nutrient found in beef and dairy improves immune response to cancer - EurekAlert

Deep Space Astronauts May Be Prone To Erectile Dysfunction … – Slashdot

As if homesickness, wasting muscles, thinner bones, an elevated cancer risk, the inescapable company of overachievers and the prospect of death in the endless vacuum of space were not enough to contend with, male astronauts may return from deep space prone to erectile dysfunction, scientists say. From a report: In what is claimed to be the first study to assess the impact of galactic radiation and weightlessness on male sexual health, Nasa-funded researchers found that galactic cosmic rays, and to a lesser extent microgravity, can impair the function of erectile tissues, with effects lasting potentially for decades. Raising their concerns in a report on Wednesday, the US researchers said they had identified "a new health risk to consider with deep space exploration." They called for the sexual health of astronauts to be closely monitored on their return from future deep space missions, noting that certain antioxidants may help to counteract the ill-effects by blocking harmful biological processes.

"While the negative impacts of galactic cosmic radiation were long-lasting, functional improvements induced by acutely targeting the redox and nitric oxide pathways in the tissues suggest that the erectile dysfunction may be treatable," said Dr Justin La Favor, an expert in neurovascular dysfunction at Florida State University and a senior author on the study. The warning comes amid a renewed focus on deep space missions, with Nasa and other major space agencies preparing for long-term expeditions to the moon and more ambitious voyages to Mars. Nasa's Artemis programme aspires to send astronauts to the moon as early as next year, with crewed missions to Mars tentatively lined up for as early as 2040.

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Deep Space Astronauts May Be Prone To Erectile Dysfunction ... - Slashdot

FDA Considers First CRISPR Gene Editing Treatment That May … – Slashdot

The U.S. Food and Drug Administration is reviewing a cutting-edge therapy called exa-cel that could potentially cure people of sickle cell disease, a painful and deadly disease with no universally successful treatment. "If approved, exa-cel, made by Boston-based Vertex Pharmaceuticals and the Swiss company CRISPR Therapeutics, would be the first FDA-approved treatment that uses genetic modification called CRISPR," reports CNN. From the report: CRISPR, or clustered regularly interspaced short palindromic repeats, is a technology researchers use to selectively modify DNA, the carrier of genetic information that the body uses to function and develop. [...] The new exa-cel treatment under FDA consideration can use the patient's own stem cells. Doctors would alter them with CRISPR to fix the genetic problems that cause sickle cell, and then the altered stem cells are given back to the patient in a one-time infusion.

In company studies, the treatment was considered safe, and it had a "highly positive benefit-risk for patients with severe sickle cell disease," Dr. Stephanie Krogmeier, vice president for global regulatory affairs with Vertex Pharmaceuticals Incorporated, told the panel. Thirty-nine of the 40 people tested with the treatment did not have a single vaso-occlusive crisis, which means the misshapen red blood cells block normal circulation and can cause moderate to severe pain. It's the top reason patients with sickle cell go to the emergency room or are hospitalized. Before the treatment, patients experienced about four of these painful crises a year, resulting in about two weeks in the hospital.

The FDA sought the independent panel's advice, in part, because this would be the first time the FDA would approve a treatment that uses CRISPR technology, but Dr. Fyodor Urnov, a professor in the Department of Molecular and Cell Biology at the University of California, Berkeley, reminded the committee CRISPR has been around for 30 years and, in that time, scientists have learned a lot about how to use it safely. "The technology is, in fact, ready for primetime," Urnov said. With this kind of genetic editing, scientists could inadvertently make a change to a patient's DNA that is off-target, and the therapy could harm the patient. [...] The FDA is expected to make an approval decision by December 8.

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FDA Considers First CRISPR Gene Editing Treatment That May ... - Slashdot

Revolutionizing the Treatment Room : BeautyHealth Launches Connected Hydrafacial Syndeo Device in Europe and Asia – Marketscreener.com

Revolutionizing the Treatment Room : BeautyHealth Launches Connected Hydrafacial Syndeo Device in Europe and Asia  Marketscreener.com

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Revolutionizing the Treatment Room : BeautyHealth Launches Connected Hydrafacial Syndeo Device in Europe and Asia - Marketscreener.com

Niacinamide: A B vitamin that improves aging facial skin … – PubMed

Background: In multiple chronic clinical studies, topical niacinamide (vitamin B3) has been observed to be well tolerated by skin and to provide a broad array of improvements in the appearance of aging facial skin (eg, reduction in the appearance of hyperpigmentated spots and red blotchiness).

Objective: To clinically determine the effect of topical niacinamide on additional skin appearance and property end points (wrinkles, yellowing, and elasticity).

Methods: Female white subjects (N = 50) with clinical signs of facial photoaging (fine lines and wrinkles, poor texture, and hyperpigmented spots) applied 5% niacinamide to half of the face and its vehicle control to the other half twice daily for 12 weeks (double blind, left-right randomized). Facial images and instrumental measures were obtained at baseline and at 4-week intervals.

Results: Analyses of the data revealed a variety of significant skin appearance improvement effects for topical niacinamide: reductions in fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness (yellowing). In addition, elasticity (as measured via cutometry) was improved. Corresponding mechanistic information is presented.

Conclusion: In addition to previously observed benefits for topical niacinamide, additional effects were identified (improved appearance of skin wrinkles and yellowing and improved elasticity).

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Niacinamide: A B vitamin that improves aging facial skin ... - PubMed

Meet Altos Labs, Silicon Valleys latest wild bet on living forever

Other hires made by Altos include Peter Walter, whose laboratory at the University of California, San Francisco, is behind a molecule that shows remarkable effects on memory. Also joining is Wolf Reik, a reprogramming specialist who recently resigned as the director of the Babraham Institute in the UK after the center said he was taking a job with another research organization now believed to be Altos. Walter and Reik declined to comment.

At least initially, Altos will be funding researchers with no immediate expectation for products or revenues. According to one person briefed by Klausner and Milner, the initial output of the company will be great science.

Altos is luring university professors by offering sports-star salaries of $1 million a year or more, plus equity, as well as freedom from the hassle of applying for grants. One researcher who confirmed accepting a job offer from Altos, Manuel Serrano of the Institute for Research in Biomedicine, in Barcelona, Spain, said the company would pay him five to 10 times what he earns now.

The philosophy of Altos Labs is to do curiosity-driven research. This is what I know how to do and love to do, says Serrano, who plans to move to Cambridge, UK to join an Altos facility there. In this case, through a private company, we have the freedom to be bold and explore. In this way it will rejuvenate me.

Any treatment for a major disease of aging could be worth billions, but Altos isnt counting on making money at first. The aim is to understand rejuvenation, says Serrano. I would say the idea of having revenue in the future is there, but its not the immediate goal.

In 2013, Serrano was among the first scientists to genetically engineer mice to produce Yamanaka factors. They all developed tumors as their cells reverted to an embryonic stage. Still, the work hinted that time could be reversed inside a living animal. You introduce the factors and they do the magic. Its very simple experimentally, even if it is not understood, says Serrano.

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Meet Altos Labs, Silicon Valleys latest wild bet on living forever

Anti-aging product – Wikipedia

Set of skin care products

Anti-aging creams are predominantly moisturiser-based cosmeceutical skin care products marketed with the promise of making the consumer look younger by reducing, masking or preventing signs of skin aging. These signs are laxity (sagging), rhytids (wrinkles), and photoaging, which includes erythema (redness), dyspigmentation (brown discolorations), solar elastosis (yellowing), keratoses (abnormal growths), and poor texture.[1] Anti-aging supplements are a set of ingestible products that are designed to reduce or diminish the effects of aging. This includes things such as vitamin supplements, powders and teas. They are designed to reduce or diminish the effects of aging. Many products seek to hide the effects of aging while others claim to alter the body's chemical balances to slow the physical effects of aging.[2] A comprehensive grading scale for anti-aging of the skin has been validated and categorizes skin aging as: laxity (sagging), rhytids (wrinkles), and the various categories of photoaging, including erythema (redness), dyspigmentation (brown discolorations), solar elastosis (yellowing), keratoses (abnormal growths), and poor texture.[3]

Despite great demand, many anti-aging products and treatments have not been proven to give lasting or major positive effects. One study found that the best performing creams reduced wrinkles by less than 10% over 12 weeks, which is not noticeable to the human eye.[4] Another study found that cheap moisturisers were as effective as high-priced anti-wrinkle creams.[5] A 2009 study at Manchester University, funded by the manufacturer of the cream, showed that a proprietary blend of ingredients had a positive effect after six months of daily application when extrapolated to a twelve month basis of comparison.[6][7] The statistical methods used to show this have been criticized.[8]

Traditionally, anti-aging creams have been marketed towards women, but products specifically targeting men are increasingly common.[9] Marketing of anti-aging products has been criticized as reinforcing ageism, particularly against women.[10] According to Toni Calasanti of Virginia Tech, anti-aging ads specifically reinforce the belief that older people should look like middle-aged people, and that old age comes with a loss of gender identity.[11]

Anti-aging creams may include conventional moisturising ingredients. They also usually contain specific ingredients claimed to have anti-aging properties, such as:

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Anti-aging product - Wikipedia

My mom taught me an anti-aging tip it looks strange but it works, people cant believe shes 72… – The US Sun

A DERMATOLOGIST'S mom has told her about an unusual beauty routine that she says slows down aging.

Skincare influencer Dr Mamina Turegano (@drmamina) uploaded a video of the 72-year-old Japanese woman demonstrating an ancient skincare process.

3

Dr Turegano shared the skincare secret as part of a series on the "sometimes-strange anti-aging tips I learned from my Japanese mom."

The video kicks off with a photo of Turegano with her mom, whose skin is clear and minimally lined.

The older woman is then shown demonstrating how to use a small wooden brush to sweep all over the skin.

The doctor goes on to explain how the anti-aging technique is called "dry brushing" and is used in Ayurvedic medicine.

She is quick to add that although there's no scientific evidence to back up the routine, it may improve the skin.

"It's thought to have benefits like exfoliation and increasing circulation," she claims.

The video then switches to Dr Turegano's mom talking as she quickly performs the brushing routine.

She stands confidently, holding her small wooden brush, and begins sweeping the bristles all over her body.

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"I usually do two to three minutes every morning," she says quietly.

"You'll have all clothes off of course. Totally naked alright?" she adds with a smile.

The video continues to show her mom lying flat on her back, brushing her bare legs.

3

She describes the importance of traveling up towards the heart.

Commenters are impressed, with one saying: "She is GLOWING"

Another added: "She has aged gracefully."

But one follower is skeptical and said: "My skin would turn red and bleed."

At the end of the video, Mamina's mom happily holds up her brush while still wearing her gym shorts and T-shirt.

She grins and says: "Happy brushing!"

3

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My mom taught me an anti-aging tip it looks strange but it works, people cant believe shes 72... - The US Sun

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Academic Institute Certificateon Aesthetics of the Face

November 4 to 5, 2022

Aesthetic & Anti-Aging Medicine World Congress

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November 5 to 6, 2022

Aesthetic & Anti-Aging Medicine World Congress

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November 17 to 19, 2022

International Congress of Aesthetic Dermatology

International Congress of Aesthetic Dermatology

November 24 to 26, 2022

FACE Bali 2023

Facial Aesthetic Conference and Exhibition - ASEAN

February 4 to 5, 2023

Aesthetic & Anti-Aging Medicine World Congress - India

Aesthetic & Anti-Aging Medicine World Congress - India

February 24-25, 2023

Monaco Advanced Facial Aesthetic Masterclass

Monaco Advanced Facial Aesthetic Masterclass

March 29, 2023

Aesthetic & Anti-Aging Medicine World Congress

Aesthetic & Anti-Aging Medicine World Congress

March 30 to April 1, 2023

Aesthetic & Anti-Aging Medicine World Congress

Aesthetic & Anti-Aging Medicine World Congress

May 5-7, 2023

Aesthetic Facial Anatomy

Aesthetic Facial Anatomy

May 12-13, 2023

Facial Aesthetic Conference and Exhibition

FACE 2023

June 23-24, 2023

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4 Anti-Aging Products Youre Using All Wrong, According To Skincare Experts – SheFinds

Before you apply yet another anti-aging cream, serum, or other product, stop right there you could be using it all wrong. Many people are unknowingly applying some of the most effective ingredients to their skin all wrong. As a result, they are wasting both precious time and money on products that could be effective if used correctly. From sunscreen tips to retinol mistakes, these are the anti-aging products skincare experts say youre using all wrong.

For starters, you are probably not applying sunscreen daily, which means youre missing out on opportunities to protect your skin from the damaging, aging effects of UV light, whether its July or December.

Preventative care is the most important step inanti-aging, says Dr. Adrienne OConnell, medical director and president ofLaguna Beach Aesthetics. You must wear sunscreen that protects against both UVA and UVB rays (broad spectrum) with an SPF 30 or higher every single day, no matter the weather. I highly recommend a 100% mineral sunscreen, which is much safer for sensitive skin and contains no added chemicals.

The second most misused product is Retinol, according to Dr. OConnell.As the ultimate go-to skincare ingredient for a younger look, retinol speeds up your cell turnover so your body can replace damaged surface cells with brighter, younger skin cells, Dr. OConnell says.More is not better when it comes to this product. It can over-dry or irritate your skin.It is also dangerous to use in the morning because it makes your skin more sensitive to sunlight.

If you choose to use a Retinol product, Dr. OConnell says it is best used at night and washed off in the morning.You also must apply sunscreen in the morning as an added precaution, Dr. OConnell says.Also, start slow.Use the product once a week and gradually increase until you are using it according to the products instructions and never use more than the instructions direct you to.

Often, people buy the products they see on TV or are advertised by a favorite celebrity without caution, warns Dr. Nadir Qazi, DO, a board-certified physician, cosmetic dermatology surgeon, and owner ofQazi Clinic. Then when you look at the ingredient list it can contain ingredients known to cause harm to skin instead. For example, a product may contain retinol to combat wrinkles, Dr. Qazi says. However, if that same product contains a coconut oil derivative like Coco-Caprylate, the product might slow wrinkling but clog the pores and cause acne.Or they may only put a small amount of active ingredients in the product. Suppose an under-eye cream advertises vitamin C as its main active ingredient. Then, using a name like sodium ascorbate, they put it at the bottom of the ingredients list. All the while, that product uses silica as a main ingredient and filler to smooth the appearance of under-eye circles while using the product without treating them.

Thats why Dr. Qazi says its imperative to look at ingredients and do your own research on whether a product can be harmful or beneficial.

Exfoliation is wonderful it makes the skin fresh and rejuvenated, Dr. Qazi says. It feels so nice and vibrant that people are often tempted to exfoliate more often than they should, and with products that do more harm than good.

Over-exfoliation makes the skin sensitive and inflamed, and the skin can begin to flake and peel away, Dr. Qazi says. In addition, as skin becomes dehydrated from over-exfoliating, collagen breaks down, which causes the skin to lose its firmness and elasticity, creating wrinkles.

To maintain a youthful glow, chemical exfoliants are a good substitute for the abrasive scrubs one might have used growing up, Dr. Qazi says. Look for alpha-hydroxy acids like glycolic and mandelic acids. These acids exfoliate efficiently, and it is easy to find lower concentrations or limit how often you use them to avoid over-exfoliation. Mandelic acid can be especially beneficial for sensitive skin as it has a larger molecular structure and is very gentle as an exfoliant.

It isnt enough to own a bathroom medicine cabinets worth of expensive anti-aging skincare products. Learning which ones you could be using wrong is key to getting healthier, more glowy skin at any age.

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4 Anti-Aging Products Youre Using All Wrong, According To Skincare Experts - SheFinds