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3 reasons to consider working with an expert mesothelioma attorney – AZ Big Media

Have you or any of your loved ones gotten diagnosed with the silent killer mesothelioma? Its often due to exposure to the asbestos mineral in industrial factories. You need not suffer in silence and wallow in poverty while trying to cater to the medical expenses or other damages. It might be somewhat challenging going up against a factory that you worked for and even considered family at one point. Thats why you need an independent and impartial expert third party to ensure you get the rightful claim. If you are yet to consider working with a mesothelioma lawyer, its time to consider it. Heres why.

When it comes to dealing with mesothelioma cases, its quite different from most of the other personal injury claims. One reason might be because you might fail to know when the asbestos exposure took place. The agency that you might have worked for might have run out of business ages ago or even filed for bankruptcy.

With a knowledgeable attorney, you can benefit from their vast and extensive research on asbestos. Thus, they are better positioned to establish if and when the asbestos was in use precisely. You are also in a better position to know about the stature of limitation for your claim when it started and its expiry date.

Mesothelioma investigation requires more than merely collecting an accident report and medical records. Asbestos experts need to get into the picture to establish when and where one was exposed. Theres also a need to know how the exposure caused the diagnosis.

It might be somewhat challenging to build a case when you have to also focus on treatment. Dedicating your time and resources might not only be financially draining, but it might also rob your peace of mind when you keep hitting dead ends. Thats why you need to get a mesothelioma lawyer, including Oberheiden law professionals who have all the time, connections, propriety database, and resources. With all these, they are in a better position to conduct a detailed investigation that your claim deserves.

Getting the ideal attorney such as Oberheiden law experts can enable you to rest easy when it comes to the upfront fee. Thus, you can have an expert pursue your claim with no upfront charges until you receive your compensation. Its a chance to get the most out of the free legal consultation. You also get to know if you have a viable claim or not, as you have so much to worry about the illness, you need not add the individualized legal representation to your plate. Its time to let the experts hold your hand and ensure you get the most viable compensation.

Its almost dumbfounding to describe the emotional anguish of realizing you or your loved one is dealing with mesothelioma. Treatment is quite costly, and emotional torture is quite real. Take it easy! You dont have to go through it all by yourself when you can get the best mesothelioma attorney to represent you on contingency until you get whats rightfully yours.

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3 reasons to consider working with an expert mesothelioma attorney - AZ Big Media

Mesothelioma Compensation Center Has Endorsed Attorney Erik Karst of Karst von Oiste To Ensure A Chemical Plant Worker with Mesothelioma Receives a…

HOUSTON, Sept. 2, 2020 /PRNewswire/ -- The Mesothelioma Compensation Center is the top branded source in the nation for the best possible financial compensation for a chemical plant or refinery worker who has been diagnosed with mesothelioma. To get the financial compensation job done for a person like this they have endorsed, and they recommend attorney Erik Karst the managing partner of the law firm of Karst von Oiste. For direct access to Erik please call 800-714-0303.

Erik Karst is one of the nation's most skilled mesothelioma attorneys and he will know exactly how to help a person with this rare cancer as well as their family members. Financial compensation for a chemical plant worker might exceed a million dollars. Erik Karst of the law firm of Karst von Oiste will go out of his way to make certain his law firm's clients stay safe during the mesothelioma compensation process. Erik Karst and his colleagues at the law firm of Karst von Oiste are responsible for over a billion dollars in financial compensation for people with mesothelioma nationwide. For direct access to attorney Erik Karst of the law firm of Karst von Oiste please call 800-714-0303 anytime. http://www.karstvonoiste.com/

According to the Mesothelioma Compensation Center says, "As a result of the Coronavirus-2020 might go down as one of the worst years in decades for compensation for people with mesothelioma-because the Chinese virus and mesothelioma share many of the same symptoms. If your loved one is a former chemical plant or refinery worker, you know for certain he had heavy exposure to asbestos decades ago and he is now in the hospital with suspected Coronavirus please tell his doctors about his asbestos exposure. There is no compensation for a person with mesothelioma-if his doctors misdiagnose him with the Coronavirus and he passes-away." https://MesotheliomaCompensationCenter.Com

The Mesothelioma Compensation Center specializes in assisting specific types of people who have been diagnosed with mesothelioma or asbestos exposure lung cancer. The group's top priority is assisting US Navy Veterans, shipyard workers, oil refinery workers, public-utility workers, chemical plant workers, manufacturing workers, power plant workers, plumbers, welders, electricians, millwrights, pipefitters, boiler technicians, machinists, nuclear power plant workers, hydro-electric workers or oil and gas field production workers. https://MesotheliomaCompensationCenter.Com

For more information about chemical workers in the United States please refer the Bureau of Labor Statistics report on this topic: https://www.bls.gov/oes/current/oes518091.htm.

According to the CDC the states indicated with the highest incidence of mesothelioma include Maine, Massachusetts, Connecticut, Maryland, New Jersey, Pennsylvania, Ohio, West Virginia, Virginia, Michigan, Illinois, Minnesota, Louisiana, Washington, and Oregon. However, a chemical plant or refinery worker with mesothelioma could live in any state including California, New York, Florida, Texas, Illinois, Kentucky, Tennessee, Mississippi, Georgia, Alabama, Wyoming, Colorado, New Mexico, Nevada, Utah, Arizona, Idaho, or Alaska. http://www.karstvonoiste.com/

For more information about mesothelioma please refer to the National Institutes of Health's web site related to this rare form of cancer: http://www.nlm.nih.gov/medlineplus/mesothelioma.html

Contact: Michael Thomas 800-714-0303 243382@email4pr.com

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Mesothelioma Compensation Center Has Endorsed Attorney Erik Karst of Karst von Oiste To Ensure A Chemical Plant Worker with Mesothelioma Receives a...

The Malignant Mesothelioma Market To Go Strong With 7.5% CAGR Between 2025 – Bulletin Line

Determination Market Research, in its business report, expounds the verifiable and momentum situation of the worldwide Malignant Mesothelioma Market as far as the creation, utilization, volume, and worth. The report examines the market into different portions, areas, and players based on request examples and development possibilities.

Pivotal data and conjecture measurements canvassed in the Malignant Mesothelioma Market report will arm both existing and developing business sector players with important bits of knowledge to create long haul systems just as keep up business congruity during an emergency, for example, the continuous COVID-19 pandemic.

The Malignant Mesothelioma Market has been estimated to be valued atUS$ 300 Mn by 2025, registering a CAGR of 7.5% over the forecast period.

The competitive analysis chapter of the report sheds light on the major developments of the prominent players operating in the Malignant Mesothelioma Market. The report provides information related to the recent mergers, acquisitions, partnerships, and other strategic alliances within the Malignant Mesothelioma Market. Further, the pricing, sales, promotional, and marketing strategies of each company are enclosed in the report.

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Our client success stories feature a range of clients from Fortune 500 companies to fast-growing startups. PMRs collaborative environment is committed to building industry-specific solutions by transforming data from multiple streams into a strategic asset.

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The Malignant Mesothelioma Market To Go Strong With 7.5% CAGR Between 2025 - Bulletin Line

CEO ‘died of mesothelioma – but it’s not clear if he ever came into contact with asbestos’ – Buckinhamshire Free Press

A retired CEO died after a short battle with mesothelioma but his death remains a mystery as it is not clear if he ever came into contact with asbestos, an inquest has heard.

Peter Day, from Amersham, was the Chief Executive Officer of an IT company before he retired.

After coming back from a holiday in Florida with chest pains earlier this year, the 76-year-old was eventually diagnosed with metastatic biphasic pleural mesothelioma primarily caused by exposure to asbestos.

Surgery was not an option after his diagnosis, and he was instead given palliative treatment by Rennie Grove. He tragically passed away with his wife and daughter at his side at home in Clifton Road on July 19.

An inquest into the death of Mr Day, held at Buckinghamshire Coroners Court in Beaconsfield on September 2, heard that as a former chief executive of a software company, it was not clear how he may have been exposed to asbestos.

Senior coroner for Bucks Crispin Butler initially recorded a narrative conclusion, which simply sets out the facts of a death, in a hearing on Wednesday.

But after later hearing a statement from Mr Day's family that had not been taken into account at the time of the inquest, Mr Butler has now concluded that he died as a result of industrial disease.

According to Companies House, Mr Day was also involved with the Wildfowl & Wetlands Trust (WWT), a leading conservation charity.

In a tribute posted on the WWT website, colleagues said Mr Day was one of its most passionate and devoted supporters, as a volunteer for more than 20 years at the London Wetland Centre, as a trustee and as chair of the council.

He had reportedly obtained his PhD in plant molecular, phylogenetic and population genetics at Queen Mary, University of London and the Royal Botanic Gardens, Kew, just two years ago.

The tribute added: Peter made huge efforts to really understand WWT. He travelled extensively to sites and wider conservation projects not just for organised events but in an informal capacity, which was appreciated by many WWT staff, volunteers and our supporters.

He held a strong vision for a better environment, could always be relied on as a source of sound and reliable advice and held a natural ability to convey encouragement to everyone he met.

He was also very supportive to the management team during the recent pandemic.

He will be hugely missed by all staff and volunteers. We send our deepest sympathy to his family.

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CEO 'died of mesothelioma - but it's not clear if he ever came into contact with asbestos' - Buckinhamshire Free Press

|VIDEO| The Todd Suddleson Closing That Cleared CertainTeed in $5M+ Asbestos Case – CVN News

Asbestos cases often turn on a paper trail as the most reliable evidence at trial, where memories of potential exposure and their sources from decades earlier can be hazy. Todd Suddleson used such a paper trail as the key to a strong closing argument that helped clear CertainTeed in a $5M-plus asbestos trial in 2018.Francisco Herrera v. CertainTeed Corp., CV2014-09632.

Francisco Herrera contended he developed mesothelioma after cutting asbestos-containing cement water pipes made by CertainTeed Corp. while he worked for SunAir Co. in the 1970s.

At trial, the plaintiff sought to paint CertainTeed as a major supplier of asbestos-containing pipe to SunAir while Herrera worked for the company. However, the defense countered Herrera failed to show he was actually exposed to CertainTeed pipe.

During his closing, Suddleson, of DeHay & Elliston LLP, walked jurors through a search of 42,000 invoices he said helped show CertainTeed pipe wasnt connected to Herreras mesothelioma.

Of those 42,000 CertainTeed invoices during the time Herrera worked at SunAir, Suddleson said only seven invoices, for two jobs, were for SunAir. Between the two jobs, there were only 33 fully-machined pieces (of pipe ordered), Suddleson told jurors, holding up a piece of pipe about a foot long. These are the ones that would be cut, so you can get a decent idea on the maximum number of cuts based on the number of [fully-machined pieces] that were ordered.

Suddleson argued there was insufficient evidence to show Herrera even worked on the two jobs for which CertainTeed supplied that pipe, and he pushed back on the plaintiffs criticism of the invoice review. They had the audacity to challenge our review of the invoices. They were like They actually had attorneys do it. Oh my! How can that possibly be credible?

Well, thats the only way to do it, and weve done it, Suddleson added.

We invited the plaintiffs to come look for themselves, Suddleson said, painting CertainTeed as the party with nothing to hide. Did they? No. Because its much easier to just question whether we found all the invoices than it is to actually do the work themselves.

Suddlesons closing argument, and his detailed accounting of the paper trial, helped deliver a defense verdict in the case.

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|VIDEO| The Todd Suddleson Closing That Cleared CertainTeed in $5M+ Asbestos Case - CVN News

Mesothelioma Deaths Seem to be on the Rise LegalScoops – Legal Scoops

Recently, the CDC or the Center for Disease Control, just released information pointing out that mesothelioma seems to be causing more deaths than recent years.

This sharp rise scares people in this organization, not to mention regular citizens.

Some of the findings say that asbestos is to blame, but the troubling thing is it might be environmental and secondary exposure, meaning people arent even expecting to be exposed to the deadly substance.

This is a dreadful cancer that attacks the mesothelium and is sometimes hard to detect. It occurs when the protective membrane that helps keep internal organs safe is plagued by a cancer.

However,it is important to understand that mesothelioma should not be mistaken as a form of lung cancer.

While both diseases affect the lungs, they occur in different parts of the lung. Mesothelioma occurs in the lining of the lungs, also known as the mesothelium.

The disease can also occur in the lining of the chest, heart, abdomen, and testicles, but it most commonly develops in the lining of the lungs, they write on their site.

The cancer is often triggered by overexposure to asbestos, and it can certainly lead to death as it has been doing to so many people throughout the years.

Most people believe that asbestos exposure is no longer a problem. Most companies dont use the material, and buildings with asbestos are usually updated.

Still, the reality is that asbestos is still here, and it is still affecting many people.

Asbestos does not only affect people who work with the material, but friends and family members could be exposed through secondary exposure if this individual brings the fibers along with him or her unknowingly.

The environment can also carry asbestos, meaning people who werent even thinking of about this issue could be affected by it.

The reality is that there are still enough commercial mining locations where asbestos is actually mined.

These locations may sometimes release asbestos into the air, and this contamination does not get dispersed as quickly as some might hope.

It should also be pointed out that people who work in locations where asbestos is mined or where rocks that contain asbestos are constantly broke may be the ones who carry these mineral fibers home.

It should also be pointed out that natural asbestos does exist in certain rocks or soils, but the amounts are relatively low.

The problem arises when construction or other kinds of activity disturbs these natural deposits and releases the asbestos.

This means that construction, road building, road repair, or even soil and rock harvesting could release asbestos into the environment.

Environmental and secondary asbestos exposure are very hard to avoid, especially because asbestos simply cannot be seen.

Furthermore, any exposure that does occur may be hard to assess properly in order to find the people who might have been responsible for this exposure, especially without the help of an experienced asbestos lawyer.

This is the reason the best way to fight this particular kind of danger is through prevention.

There are a number of steps a person can take to prevent asbestos exposure or at least reduce the risk.

It may feel that this type of exposure is impossible to run away from, but the reality is that knowledge can make a difference.

First off, a family that works in construction needs to make sure that all clothes and shoes are removed quickly as well as sterilized.

In fact, it might be a good idea to simply remove shoes before entering the house since shoes are likely to collect dust while out, which could have some natural occurring asbestos.

Of course, it is important to avoid old buildings that look like they are in a state of disrepair as well as locations that look unkempt and dusty.

It might also be a good idea for a person to only use asbestos-free soil and landscaping material when he or she needs to work on his or her home.

It might be a good idea to wet any ground that is going to be gardened on or played on by kids. The moisture helps keep dust from rising into the atmosphere where it can be easily breathed.

Asbestos is a real threat, and it is important that this is pointed out because many people still think it is a bygone problem.

Clearly, this issue is still here, and precautions must be taken. Laws must continue to regulate activity that may expose people to it.

The senior editor of Legal Scoops, Jacob Maslow, has founded several online newspapers including Daily Forex Report and Conservative Free Press. He also works as an Online Marketing Consultant providing web marketing services.

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Mesothelioma Deaths Seem to be on the Rise LegalScoops - Legal Scoops

Could Tumor Treating Fields and Keytruda Work Together for Mesothelioma? – Mesothelioma Guide

Two recently approved therapies for mesothelioma may soon team up in a study.

Novocure, the manufacturer of the tumor treating fields device NovoTTF-100L, announced a partnership with Merck, the manufacturer of the popular immunotherapy drug Keytruda. The two leaders in oncology will collaborate on a non-small cell lung cancer clinical trial.

If that goes well, the next step might be a mesothelioma study.

Keytruda, the brand name for pembrolizumab, received approval early in 2020 from the United States Food and Drug Administration (FDA) for specific pleural mesothelioma cases. The treatment is available for patients who express high levels of PD-L1, the cancerous protein that Keytruda can neutralize.

The NovoTTF-100L System device, which was rebranded as Optune Lua, passed the FDAs rigorous approval test in 2019. It was the first FDA approval for mesothelioma in 15 years. Optune Lua is available for pleural mesothelioma patients who cannot undergo surgery. It was approved to be combined with chemotherapy.

If you have mesothelioma and want to learn more about either therapy, reach out to our registered nurse and patient advocate, Jenna Campagna. She can also provide details on clinical trials for mesothelioma, giving you potential access to emerging treatment combinations that could significantly improve your prognosis. Email her at jenna@mesotheliomaguide.com.

Optune Lua sends low-intensity electric waves through the cancer location in your body. Cancer cells are sensitive to these fields, which are tuned to specific frequencies. The waves disrupt cell division, prevent the tumors from growing and eventually cause the cells to die. Patients barely feel the waves initially, and they eventually grow accustomed to them.

Pleural mesothelioma patients wear the device on their chest for most of the day and night. They can even sleep with the device, which is another reason why Optune Lua is one of the least invasive therapies for mesothelioma.

Not only is the device easy and safe to use, but the life expectancy and survival results for mesothelioma patients are exceptional. The median overall survival from one study was 18.2 months. Nearly two-thirds were alive after one year, which is a much better rate than chemotherapy on its own.

Since its FDA approval just one year ago, the Optune Lua device is offered at hospitals across the country. The number of institutions with access to this treatment continues to grow.

Keytruda is the brand name for pembrolizumab, an immunotherapy checkpoint inhibitor drug. Keytruda explicitly stifles the connection between two protein receptors: PD-1 on the bodys cancer-fighting T-cells; and PD-L1 on mesothelioma cells.

When these protein receptors connect, T-cells ignore mesothelioma cells in their quest to locate diseases and protect the body. Keytruda breaks or blocks the connection, which aids the immune systems natural defenses.

In a recent study, 34% of mesothelioma patients with high levels of PD-L1 survived for two years thanks to Keytruda. Nearly 20% had progression-free survival (meaning their disease did not grow or spread) for two years.

The non-small cell lung cancer study is a phase 2 trial explicitly for PD-L1-positive patients. Itll enroll up to 66 participants and begin before the end of 2020. The researchers will examine the response rate, overall survival, progression-free survival and disease-control rate.

William Doyle, the executive chairman of Novocure, said that scientific studies suggest that the use of tumor treating fields together with an anti-PD-1 therapy can potentially augment the immune response, resulting in improved tumor control.

Non-small cell lung cancer and pleural mesothelioma are similar in numerous ways. First, the two cancers develop in the same general region: pleural mesothelioma in the thin tissue lining between the lungs and chest (the pleura); non-small cell lung cancer in the tissue of the lungs. Pleural mesothelioma can spread to the lungs, and treatment sometimes involves removing a lung.

The two diseases also resemble one another. Adenocarcinoma is a type of non-small cell lung cancer. Doctors often confuse it and pleural mesothelioma when looking at scans.

Theyre also linked to the same culprit: asbestos. Inhaling or swallowing loose, sharp asbestos fragments can lead to cellular irritation, either on lung tissue or in the pleura. Asbestos is the only known cause of pleural mesothelioma, and it is one of multiple potential reasons for non-small cell lung cancer.

The similarities between the two cancers suggest that a Keytruda-Optune Lua combination could also work for mesothelioma. If the non-small cell lung cancer trial is a success, then the partnerships scope should expand.

Doyle hinted at the possibility of testing the pairing on more cancer types. He called the collaboration an important combination study as we strive to extend survival in some of the most aggressive forms of cancer.

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Devin Golden is the content writer for Mesothelioma Guide. He produces mesothelioma-related content on various mediums, including the Mesothelioma Guide website and social media channels. Devin's objective is to translate complex information regarding mesothelioma into informative, easily absorbable content to help patients and their loved ones.

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Could Tumor Treating Fields and Keytruda Work Together for Mesothelioma? - Mesothelioma Guide

US Navy Veterans Mesothelioma Advocate Offers the Family of a Navy Veteran with Confirmed Mesothelioma Immediate Access to Attorney Erik Karst of…

HOUSTON, Sept. 3, 2020 /PRNewswire/ --The US Navy Veterans Mesothelioma Advocate says, "We are offering a family whose Navy Veteran husband or dad has just been diagnosed with mesothelioma anywhere in the US immediate access to attorney Erik Karst of the law firm of Karst von Oiste at 800-714-0303 to discuss compensation and how to expedite results. Mesothelioma compensation for a Navy Veteran can frequently exceed a million dollars and the financial claims do not involve suingthe navy.

"Erik Karst is one of the nation's most experienced mesothelioma attorneys and he and his remarkable colleagues at Karst von Oiste are responsible for over a billion dollars in compensation for people with mesothelioma nationwide - and they specialize in assisting Navy Veterans with this rare cancer caused by asbestos exposure. For direct access to attorney Erik Karst of Karst von Oiste, please call 800-714-0303."www.karstvonoiste.com/

The US Navy Veterans Mesothelioma Advocate is a passionate advocate for a Navy Veteran with mesothelioma and their family members. They are urging the family of a Navy Veteran who is over 60 years old and who had significant exposure to asbestos in the navy in the 1960's or 1970's to tell his physicians about the asbestos exposure if he has been hospitalized for suspected Coronavirus. The Coronavirus and mesothelioma have similar symptoms. The Advocate fears that many Navy Veterans who had mesothelioma were at least initially diagnosed with the Coronavirus. There is no compensation for the Coronavirus.https://USNavyMesothelioma.Com

For a listing of all types of current and past US Navy warships please review the US Navy website on this topic:https://www.navy.mil/navydata/our_ships.asp

According to the Veterans Administration some of the worst types of asbestos exposure occurred when a US Navy Veteran was stuck on their ship in dry dock or undergoing a major overhaul in shipyards located in Washington, Virginia, Connecticut, California, Maine, Massachusetts, Pennsylvania, New York, Louisiana, Hawaii or Georgia. http://www.karstvonoiste.com

For more information about mesothelioma please refer to the National Institutes of Health's web site related to this rare form of cancer:https://www.cancer.gov/types/mesothelioma.

Media Contact: Michael Thomas [emailprotected] 800-714-0303

SOURCE US Navy Veterans Mesothelioma Advocate

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US Navy Veterans Mesothelioma Advocate Offers the Family of a Navy Veteran with Confirmed Mesothelioma Immediate Access to Attorney Erik Karst of...

Mesothelioma Victims Center Appeals to the Family of a Paper Mill Worker Who Has Mesothelioma to Call Attorney Erik Karst of Karst von Oiste to…

HOUSTON, Sept. 1, 2020 /PRNewswire/ --The Mesothelioma Victims Center says, "We are appealing to the wife, or adult son/daughter of a paper mill worker who has been diagnosed with mesothelioma to not play lawyer roulette by calling for 'free' books or lawyer sponsored 'claims offices' because you and your loved one do not have time for nonsense. We are advocates for people with mesothelioma and we want them to receive the very best compensation results. To get the mesothelioma compensation job for former a pulp and paper mill worker who has this rare cancer we have endorsed attorney Erik Karst and his amazing team at the law firm of Karst von Oiste. Erik Karst is one of the nation's leading mesothelioma attorneys and he is always happy to explain what is involved with mesothelioma compensation anytime at 800-714-0303." http://www.karstvonoiste.com/

Because of the Coronavirus many people who had mesothelioma delayed seeing a doctor back in May or June because they did not want to get any sicker than they already were and or they went to an ER, and instead of being treated for mesothelioma, they were treated for COVID-19. 2020 might go down as the worst year for mesothelioma compensation in decades, because rather than being diagnosed with the rare cancer they had mesothelioma - they were diagnosed with the Coronavirus. Without a confirmed diagnosis for mesothelioma-financial compensation is almost impossible.

"If after being initially diagnosed with the Coronavirus the doctors finally figured out you or your loved one has mesothelioma, or suspected mesothelioma, please call attorney Erik Karst of the law firm of Karst von Oiste. Erik and his colleagues at the law firm of Karst von Oiste have been assisting people with mesothelioma for decades and they are responsible for over a billion dollars for people like this. The average age for a person with mesothelioma in the US is 72 years old. For direct access to attorney Erik Karst of the law firm of Karst von Oiste please call 800-714-0303 anytime."www.karstvonoiste.com/

The states with the most pulp and paper mill workers Include: Washington, Oregon, Idaho, Arkansas, California, Ohio, Georgia, Wisconsin, Minnesota, Mississippi, Alabama, North Carolina, Tennessee, New York, and New Hampshire.www.karstvonoiste.com/

For more information about wood using mills in the United States please refer to the following website:https://www.srs.fs.usda.gov/econ/data/mills/.

Each year about 3000 US citizens will be diagnosed with mesothelioma. Mesothelioma is caused by exposure to asbestos. High-risk work groups for exposure to asbestos include US Navy Veterans, power plant workers, shipyard workers, oil refinery workers, steel mill workers, miners, manufacturing workers, pulp or paper mill workers, millwrights, welders, plumbers, electricians, auto mechanics, machinists, construction workers, rail road workers, and firemen. Typically, the exposure to asbestos for these types of workers occurred in the 1950's, 1960's, 1970's, or 1980's.https://MesotheliomaVictimsCenter.Com

According to the CDC the states indicated with the highest incidence of mesothelioma include Maine, Massachusetts, Connecticut, Maryland, New Jersey, Pennsylvania, Ohio, West Virginia, Virginia, Michigan, Illinois, Minnesota, Louisiana, Washington, and Oregon.

However, based on the calls the Mesothelioma Victims Center receives a pulp or paper mill worker with confirmed mesothelioma could live in any state including New York, Florida, California, Texas, Illinois, Ohio, Iowa, Indiana, Missouri, North Carolina, Kentucky, Tennessee, Georgia, Alabama, Oklahoma, Arkansas, Kansas, Nebraska, North Dakota, Wyoming, Colorado, New Mexico, Utah, Nevada, Arizona, Idaho, or Alaska.www.karstvonoiste.com/

For more information about mesothelioma please refer to the National Institutes of Health's web site related to this rare form of cancer:https://www.cancer.gov/types/mesothelioma.

Media Contact:Michael Thomas[emailprotected] 800-714-0303

SOURCE Mesothelioma Victims Center

https://MesotheliomaVictimsCenter.Com

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Mesothelioma Victims Center Appeals to the Family of a Paper Mill Worker Who Has Mesothelioma to Call Attorney Erik Karst of Karst von Oiste to...

AHN Cancer Institute is First in Pittsburgh Region to Offer Optune Lua, a Wearable, Non-Invasive Treatment for Mesothelioma – PR Web

A model demonstrates how mesothelioma patients can easily take Optune Lua with them during their daily lives.

PITTSBURGH (PRWEB) September 03, 2020

AHN Cancer Institute is First in Pittsburgh Region to Offer Optune Lua, a Wearable, Non-Invasive Treatment for Mesothelioma

Terry OKeefe and his wife Diane love to hike and travel in their RV. The Grove City couple was hiking in the Midwest a year and a half ago when Terry began experiencing alarming symptoms: shortness of breath, racing heart, fainting.

Back in Pennsylvania, doctors made the diagnosis: malignant pleural mesothelioma, a rare and aggressive cancer that attacks the lining of the lungs, abdomen and heart. Median survival is only about one year. Mesothelioma is strongly connected to asbestos exposure, and Terry was exposed to the substance during his years working as a boiler operator in the U.S. Navy.

Terry underwent surgery and chemotherapy, both standard treatments for mesothelioma. Then Zachary D. Horne, MD, a radiation oncologist who practices at Allegheny Health Network Cancer Institutes center in Beaver County, as well as at Allegheny General and West Penn hospitals, offered Terry a chance to try a new option.

Optune Lua, a wearable, portable device that delivers low-grade electrical fields to the tumors, is the first new FDA-approved treatment for mesothelioma in 15 years. AHN Cancer Institute is the only center in the region offering Optune Lua for mesothelioma, and Terry was the second patient in Pennsylvania to receive the treatment.

Mesothelioma is a devastating diagnosis. We are thrilled to offer our patients Optune Lua, a treatment that can potentially extend their lives and improve their quality of life, Dr. Horne said. The treatment is non-invasive and delivers treatment directly to the tumor, and so most patients experience only minor side effects.

Optune Lua users can continue with normal daily activities during treatment. Small adhesive patches called transducer arrays are placed on the patients chest and back, and are connected by wire to a battery that the patient carries either in a backpack or across the shoulder. The electrical fields work by disrupting the process by which cancer cells make copies of themselves.

In a clinical trial of 80 patients with unresectable or metastatic and previously untreated malignant pleural mesothelioma who were treated with Optune Lua plus chemotherapy, median survival was 18.2 months, and 97 percent of patients saw their mesothelioma either shrink or stop growing.

As for Terry, the lower part of his lung tumor has completely disappeared, while the upper part has grown only slightly. Dr. Horne is adjusting the patches so that more of the electrical fields are directed to the upper lung, and doctors are also adding a newer immunotherapy to Terrys regime. Terry and his wife arent back to RVing yet, but are enjoying short hikes near their home in the company of their two dogs

We look forward to providing Optune Lua as a treatment option for additional patients who may otherwise feel that they have little hope for the future, Dr. Horne said.

The Optune Lua therapy is typically not covered by insurance plans at this time. Novocure, the manufacturer, however, has financial assistance available for qualified patients.

About Allegheny Health Network and the AHN Cancer Institute

Allegheny Health Network, a Highmark Health Company, is a western Pennsylvania-based integrated healthcare system that serves patients from across a five-state region that includes western Pennsylvania and the adjacent regions of Ohio, West Virginia, Maryland, and New York. The Networks Cancer Institute employs more than 200 physicians and 500 oncology professionals who provide a complete spectrum of oncology care at 24 affiliated oncology clinics, including access to state-of-the-art technologies and new therapies being explored in hundreds of clinical cancer trials. The Cancer Institute has the only cancer program in the Pittsburgh region accredited as an Integrated Network Cancer Program by the American College of Surgeons Commission on Cancer, and its radiation oncology program is the largest in the country accredited by the American Society for Radiation Oncology. AHN Cancer Institute is a Quality Oncology Practice Initiative certified practice, and is accredited by the Foundation for Accreditation of Cellular Therapy, National Accreditation Program for Breast Centers and the National Accreditation Program for Rectal Cancer. AHN also has a formal affiliation with the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, one of the nations 41 comprehensive cancer centers designated by the National Cancer Institute, for research, medical education and clinical services.

About Optune LuaOptune Lua is a noninvasive, antimitotic cancer treatment for MPM. Optune Lua delivers Tumor Treating Fields to the region of the tumor.Tumor Treating Fields is a cancer therapy that uses electric fields tuned to specific frequencies to disrupt cell division, inhibiting tumor growth and causing affected cancer cells to die. Tumor Treating Fields does not stimulate or heat tissue and targets dividing cancer cells of a specific size. Tumor Treating Fields causes minimal damage to healthy cells. Mild to moderate skin irritation is the most common side effect reported. Tumor Treating Fields is approved in certain countries for the treatment of adults with glioblastoma and in the U.S. for mesothelioma, two of the most difficult cancer types to treat. The therapy shows promise in multiple solid tumor types including some of the most aggressive forms of cancer.Caution: Federal law restricts this device to sale by or on the order of a physician. Humanitarian Device. Authorized by Federal Law for use in the treatment of adult patients with unresectable, locally advanced or metastatic, malignant pleural mesothelioma concurrently with pemetrexed and platinum-based chemotherapy. The effectiveness of this device for this use has not been demonstrated.

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AHN Cancer Institute is First in Pittsburgh Region to Offer Optune Lua, a Wearable, Non-Invasive Treatment for Mesothelioma - PR Web

Mesothelioma Compensation Center Urges the Family of a Plumber or Electrician with Confirmed Mesothelioma to Call Attorney Erik Karst of the Karst von…

HOUSTON, Aug. 26, 2020 /PRNewswire/ --The Mesothelioma Compensation Center is urging the wife, son or daughter of a former plumber or electrician who has just been diagnosed with diagnosed with mesothelioma in any state to please call attorney Erik Karst of the law Karst von Oiste anytime at 800-714-0303. Erik Karst is one of the nation's leading mesothelioma attorneys and he will be able to advise a person like this or their family about compensation and what will be involved in getting the best possible financial settlement results. Frequently mesothelioma compensation for a plumber or an electrician can exceed a million dollars.

Some of the key factors in mesothelioma compensation include how, where and when a person with mesothelioma was exposed to asbestos-as well as having a very skilled attorney to create a pathway. Erik Karst of the law firm of Karst von Oiste is such an attorney. For direct access to attorney Erik Karst of the law firm of Karst von Oiste please call 800-714-0303 anytime.www.karstvonoiste.com

The Mesothelioma Compensation Center says, "We know that because of the Coronavirus many people with mesothelioma or their family members might conclude that hiring a local car accident attorney might sound like a better option than hiring one of the nation's top mesothelioma compensation law firms. Please don't-do this or settle for a 'free' generic book about this rare cancer caused by asbestos exposure. Before a plumber or an electrician with mesothelioma hires a lawyer to assist with mesothelioma compensation in any state please call attorney Erik Karst of the law firm of Karst von Oiste at 800-714-0303 anytime. We think you will be glad you did."www.karstvonoiste.com

For a state by state list of requirements for electrical contractors please review the following website:https://www.harborcompliance.com/information/electrical-contractor-license.

For a state by state list of requirements for a plumber please review the following website:https://www.harborcompliance.com/information/plumbing-contractor-license.

The Mesothelioma Compensation Center specializes in assisting specific types of people who have been diagnosed with mesothelioma. These people include the US Navy Veterans, oil refinery workers, power plant workers, nuclear power plant workers, public utility workers, hydro-electric workers, chemical plant workers, plumbers, electricians, welders, or oil and gas production workers. In most instances these people were exposed to asbestos in the 1950's, 1960's, 1970's, or 1980's.https://MesotheliomaCompensationCenter.com

The states with the highest incidence of mesothelioma include Maine, Massachusetts, Connecticut, Maryland, New Jersey, Pennsylvania, Ohio, West Virginia, Virginia, Michigan, Illinois, Minnesota, Louisiana, Washington, and Oregon.

However, an electrical worker or electrician with a confirmed mesothelioma could live in any state including California, New York, Florida, Texas, Illinois, Ohio, Iowa, Indiana, Tennessee, North Carolina, Mississippi, Georgia, Nebraska, South Dakota, North Dakota, Wyoming, Colorado, New Mexico, Nevada, Utah, Arizona, Idaho, or Alaska.www.karstvonoiste.com

For more information about mesothelioma please refer to the National Institutes of Health's web site related to this rare form of cancer:https://www.cancer.gov/types/mesothelioma.

Media Contact:

Michael Thomas800-714-0303[emailprotected]

SOURCE Mesothelioma Compensation Center

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Find Mesothelioma Treatment Near You – Mesothelioma.net Blog

This page has been fact checked by an experienced mesothelioma Patient Advocate. Sources of information are listed at the bottom of the article.

We make every attempt to keep our information accurate and up-to-date.

Please Contact Us with any questions or comments.

With a diagnosis of mesothelioma, it is essential to find the best possible treatment and specialists. To find mesothelioma treatment near you, check out the nations top cancer centers and the leading mesothelioma experts.

Mesothelioma is a rare condition, which means most doctors will never work with a patient with this diagnosis. Even oncologists, who specialize in cancer, rarely see mesothelioma patients. Specialists in mesothelioma offer patients more:

No matter where you live in the U.S., good cancer treatment is not far. If you do live in a more remote area, you may need to travel to another state, but the best treatment centers, staffed by mesothelioma specialists, are in all regions:

When it comes to treating mesothelioma, getting care from specialists and cancer centers is important. A typical hospital is not equipped to provide the best possible care for this difficult and rare cancer. Look for these types of treatment facilities and dont settle for less.

A cancer center is a medical facility that specializes in diagnosing and treating cancers of all types. They staff oncologists as well as a range of other types of doctors, nurses, and technicians to provide the best care for patients with cancer. Some of these facilities may have mesothelioma specialists.

A comprehensive cancer center is a facility that has received special recognition from the National Cancer Institute. Founded in 1971, the designation from the NCI means that a facility has met certain rigorous standards for both patient care and research. The network of comprehensive cancer centers is essential for advancing the prevention, diagnosis, and treatment of all types of cancer.

You are more likely to find a mesothelioma specialist at one of these facilities than at a non-designated cancer center. Not every state has a comprehensive cancer center, but there are 51 across the country in most states.

Veterans with mesothelioma can get free healthcare through the VA. Any hospital in the system can provide cancer care, but there are a couple of VA locations that are staffed by mesothelioma specialists and with related research and clinical trials: Boston, Los Angeles, Miami, and Houston.

A clinical trial is a study conducted with real patients in order to research the safety and effectiveness of a treatment, procedure, diagnostic technique, or prevention measure. By the time a new drug or treatment makes it to a clinical trial, it has already been through extensive laboratory testing.

To get treatment through a clinical trial, you will first need to discuss it with your medical team and determine if you meet eligibility requirements. Trials are run all over the country, so you may need to travel to participate, or you may be able to find an appropriate study near you.

Your journey with a mesothelioma diagnosis will likely begin with your regular doctor. They can refer you to an oncologist, but you will probably need a more expert specialist with experience in mesothelioma. Consider all these factors when making treatment choices:

Choosing your treatment team is the most important thing you can do after receiving a mesothelioma diagnosis. Getting care soon is essential, but take some time to research and find the right treatment center and doctors for your needs.

Dave has been a mesothelioma Patient Advocate for over 10 years. He consistently attends all major national and international mesothelioma meetings. In doing so, he is able to stay on top of the latest treatments, clinical trials, and research results. He also personally meets with mesothelioma patients and their families and connects them with the best medical specialists and legal representatives available.

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Find Mesothelioma Treatment Near You - Mesothelioma.net Blog

Mesothelioma Victims Center Offers a Person with Recently Diagnosed Mesothelioma Nationwide Direct Access to Attorney Erik Karst of Karst von Oiste –…

HOUSTON, Aug. 25, 2020 /PRNewswire/ -- The Mesothelioma Victims Center says, "We are offering a person with recently diagnosed mesothelioma in any state or their family members direct access to attorney Erik Karst, the managing partner of the law firm of Karst von Oiste with one call to 800-714-0303 anytime. Because of the Coronavirus-2020 might go down as one of the worst years for mesothelioma compensation in decades-not because there are fewer people who will develop mesothelioma this year-but instead of being diagnosed with this rare cancer caused by asbestos exposure-they are being diagnosed with COVID-19. The Coronavirus and mesothelioma have similar symptoms. There is no compensation that we are aware of for the Coronavirus.

"Financial compensation for mesothelioma might exceed a million dollars. Mesothelioma compensation can be so significant it might allow the person with this rare cancer to create a legacy for their family, their children and even their grandchildren."www.karstvonoiste.com/

Mesothelioma compensation is determined based on how, where and when the person with this rare cancer was exposed to asbestos. The other ingredient in the best possible mesothelioma compensation settlement result is hiring some of the nation's most skilled mesothelioma lawyers. The Mesothelioma Victims Center has endorsed attorney Erik Karst of the law firm of Karst von Oiste to assist people with mesothelioma compensation---nationwide. Erik Karst and his colleagues at Karst von Oiste have been assisting people with mesothelioma for decades and they are responsible for well over a billion dollars in compensation for people like this. For direct access to attorney Erik Karst of the law firm of Karst von Oiste please call 800-714-0303. "We think you will be glad you did."www.karstvonoiste.com/

Each year about 3000 US citizens will be diagnosed with mesothelioma. Mesothelioma is caused by exposure to asbestos. High -risk work groups for exposure to asbestos include US Navy Veterans, power plant workers, shipyard workers, oil refinery workers, steel mill workers, miners, manufacturing workers, pulp or paper mill workers, millwrights, welders, plumbers, electricians, auto mechanics, machinists, construction workers, rail road workers, and firemen. Typically, the exposure to asbestos for these types of workers occurred in the 1950's, 1960's, 1970's, or 1980's.https://MesotheliomaVictimsCenter.Com

According to the CDC the states indicated with the highest incidence of mesothelioma include Maine, Massachusetts, Connecticut, Maryland, New Jersey, Pennsylvania, Ohio, West Virginia, Virginia, Michigan, Illinois, Minnesota, Louisiana, Washington, and Oregon.

However, based on the calls the Mesothelioma Victims Center receives a person with confirmed mesothelioma could live in any state including New York, Florida, California, Texas, Illinois, Ohio, Iowa, Indiana, Missouri, North Carolina, Kentucky, Tennessee, Georgia, Alabama, Oklahoma, Arkansas, Kansas, Nebraska, North Dakota, Wyoming, Colorado, New Mexico, Utah, Nevada, Arizona, Idaho, or Alaska.www.karstvonoiste.com/

For more information about mesothelioma please refer to the National Institutes of Health's web site related to this rare form of cancer:https://www.cancer.gov/types/mesothelioma.

Media contact:Michael Thomas[emailprotected] 800-714-0303

SOURCE Mesothelioma Victims Center

Mesothelioma Victims Center

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Ready To Use Malignant Pleural Mesothelioma Treatment Market Growth and Forecast 2019-2020 – The Scarlet

Malignant Pleural Mesothelioma Treatment Market 2018: Global Industry Insights by Global Players, Regional Segmentation, Growth, Applications, Major Drivers, Value and Foreseen till 2024

The report provides both quantitative and qualitative information of global Malignant Pleural Mesothelioma Treatment market for period of 2018 to 2025. As per the analysis provided in the report, the global market of Malignant Pleural Mesothelioma Treatment is estimated to growth at a CAGR of _% during the forecast period 2018 to 2025 and is expected to rise to USD _ million/billion by the end of year 2025. In the year 2016, the global Malignant Pleural Mesothelioma Treatment market was valued at USD _ million/billion.

This research report based on Malignant Pleural Mesothelioma Treatment market and available with Market Study Report includes latest and upcoming industry trends in addition to the global spectrum of the Malignant Pleural Mesothelioma Treatment market that includes numerous regions. Likewise, the report also expands on intricate details pertaining to contributions by key players, demand and supply analysis as well as market share growth of the Malignant Pleural Mesothelioma Treatment industry.

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EPA Draft Risk Assessment on Asbestos Flawed and could be Problematic for Automotive Friction Defendants – Lexology

The United States Environmental Protection Agency (EPA) is currently conducting a chemical risk evaluation of asbestos. The EPAs 310-page Draft Risk Evaluation for Asbestos (the Draft) identified risks for a variety of potential asbestos exposures. The Draft found that acceptable cancer risks were exceeded for much work with automotive brakes and clutches. If these findings are adopted in the final evaluation, defendants can expect asbestos plaintiffs counsel to trumpet the evaluation to juries, even though (as described below and detailed in the attached article) the analysis is flawed and inconsistent with both the scientific literature and legal standards regarding cancer causation.

The Draft looked at exposures to occupational mechanics, bystanders, and do-it-yourself mechanics. The only asbestos fiber type the EPA evaluated was commercial chrysotile, and the only potential causative diseases the EPA evaluated were mesothelioma and lung cancer. The EPA chose to evaluate acceptable cancer risks to individuals based on an Inhalation Unit Risk of 0.16 per fiber/cc.

The Draft found that acceptable cancer risks were exceeded for brake and clutch installation and removal for occupational mechanics at both high-end and central tendency exposure levels and for occupational non-users at all high-end levels. For brake repair and replacement performed indoors with compressed air, the Draft found that acceptable risk levels were exceeded for do-it-yourself mechanics and bystanders of do-it-yourself mechanics at high-end and central tendency levels. For brake work performed outdoors, the Draft found that acceptable risks levels were exceeded for do-it-yourself mechanics at high-end tendency levels when mechanic work was performed 30 minutes per day with 62 years of cumulative exposure starting at age 16.

While the final risk assessment has not been published, the conclusions found in the current Draft lead to concern that these findings will cause confusion or even improperly influence jurors in future asbestos trials. A finding by the EPA that working with and around asbestos-containing brakes and clutches leads to an unacceptable risk of mesothelioma and lung cancer would be used in the opening statements of every asbestos plaintiffs attorney in the country. Although the assessment is based on many assumptions that are not realistic, excludes large swaths of relevant scientific and medical studies, and makes conclusions regarding cancer causation that are entirely out of line with all current legal standards, it would be complicated and difficult to explain in necessary detail to a jury. It would simply be another factoid that will be used to persuade jurors that there is no safe level of chrysotile asbestos exposure and that all exposures cause disease. Surely, many hours of drafting and many tons of ink will be spilt in attempts to keep the findings of the EPA out of the courtroom through pre-trial motions to exclude and motions in limine. This is a future that will soon become all too real if there are not considerable changes made between the current Draft and the EPAs final risk evaluation.

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EPA Draft Risk Assessment on Asbestos Flawed and could be Problematic for Automotive Friction Defendants - Lexology

US Navy Veterans Lung Cancer Advocate Urges the Family of a Navy Veteran with Lung Cancer to Call the Lawyers at Karst von Oiste About Possible…

HOUSTON, Aug. 31, 2020 /PRNewswire/ --The US Navy Veterans Lung Cancer Advocate is urging the family of a Navy Veteran who now has lung cancer and who had heavy exposure to asbestos in the service in the 1960's or 1970's to please call the lawyers at the law firm of Karst von Oiste at 800-714-0303. Financial compensation for person like this might exceed $100,000-especially if the Navy Veteran's exposure to asbestos occurred on a submarine. The typical Navy Veteran the group is trying to identify is well over 60 years old and it does not matter if they smoked cigarettes. Most Navy Veterans or people with lung cancer and who had significant exposure to asbestos prior to 1982 do not realize the $30 billion dollar-asbestos trust funds were set up for them too.

The Advocate says, "If your husband or dad has lung cancer and he is a Navy Veteran who served on a navy submarine or ship-please ask him if he was constantly being exposed to asbestos. Again, the person we are trying to identify is over 60 years old-and we are certain he will recall the exposure. If he answers-yes-he was exposed to asbestos-please call the lawyers at the law firm of Karst von Oiste at 800-714-0303.

"The law firm of Karst von Oiste is one of the nation's leading law firms that specializes in compensation for asbestos exposure lung cancer and mesothelioma and they will know exactly how to help a person like this. The person's compensation does not involve a lawsuit against the navy. For direct access to the lawyers at Karst von Oiste please call 800-714-0303 anytime. We think you will be glad you did."www.karstvonoiste.com/

High-risk workplaces for asbestos exposure include the US Navy, shipyards, power plants, public utilities, manufacturing factories, chemical plants, oil refineries, mines, smelters, pulp and paper mills, aerospace manufacturing facilities, offshore oil rigs, demolition construction work sites, railroads, automotive manufacturing facilities, or auto brake shops. With lung cancer caused by asbestos exposure the lung cancer may not show up until decades after the exposure.https://USNavyLungCancer.Com

According to the American Cancer Society for nonsmokers who have been exposed to asbestos in their workplace the risk of lung cancer is five times that of unexposed workers. https://www.cdc.gov/cancer/lung/statistics/index.htm.

States with the highest incidence of lung cancer include Kentucky, West Virginia, Maine, Tennessee, Mississippi, Ohio, Indiana, Louisiana, Arkansas, Missouri, North Carolina, Rhode Island, Alabama, and Delaware.

However, asbestos exposure lung cancer can happen in any state including California, New York, Texas, Florida, Massachusetts, Connecticut, Pennsylvania, New Jersey, Illinois, Wisconsin, Minnesota, Nebraska, New Mexico, North Dakota, Wyoming, Utah, Montana, Idaho, Arizona, Washington, Oregon or Alaska. http://www.karstvonoiste.com/

For more information about asbestos exposure lung cancer and mesothelioma please visit the CDC's website on these topics:https://www.atsdr.cdc.gov/asbestos/health_effects_asbestos.html.

Contact:Michael Thomas800-714-0303243378@email4pr.com

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Mesothelioma – Wikipedia

Cancer associated with asbestos

Mesothelioma is a type of cancer that develops from the thin layer of tissue that covers many of the internal organs (known as the mesothelium).[9] The most common area affected is the lining of the lungs and chest wall.[1][3] Less commonly the lining of the abdomen and rarely the sac surrounding the heart,[10] or the sac surrounding the testis may be affected.[1][11] Signs and symptoms of mesothelioma may include shortness of breath due to fluid around the lung, a swollen abdomen, chest wall pain, cough, feeling tired, and weight loss.[1] These symptoms typically come on slowly.[2]

More than 80% of mesothelioma cases are caused by exposure to asbestos.[3] The greater the exposure the greater the risk.[3] As of 2013, about 125 million people worldwide have been exposed to asbestos at work.[12] High rates of disease occur in people who mine asbestos, produce products from asbestos, work with asbestos products, live with asbestos workers, or work in buildings containing asbestos.[3] Asbestos exposure and the onset of cancer are generally separated by about 40 years.[3] Washing the clothing of someone who worked with asbestos also increases the risk.[12] Other risk factors include genetics and infection with the simian virus 40.[3] The diagnosis may be suspected based on chest X-ray and CT scan findings, and is confirmed by either examining fluid produced by the cancer or by a tissue biopsy of the cancer.[2]

Prevention centers around reducing exposure to asbestos.[4] Treatment often includes surgery, radiation therapy, and chemotherapy.[5] A procedure known as pleurodesis, which involves using substances such as talc to scar together the pleura, may be used to prevent more fluid from building up around the lungs.[5] Chemotherapy often includes the medications cisplatin and pemetrexed.[2] The percentage of people that survive five years following diagnosis is on average 8% in the United States.[6]

In 2015, about 60,800 people had mesothelioma, and 32,000 died from the disease.[7][8] Rates of mesothelioma vary in different areas of the world.[3] Rates are higher in Australia, the United Kingdom, and lower in Japan.[3] It occurs in about 3,000 people per year in the United States.[13] It occurs more often in males than females.[3] Rates of disease have increased since the 1950s.[3] Diagnosis typically occurs after the age of 65 and most deaths occur around 70 years old.[3] The disease was rare before the commercial use of asbestos.[3]

Symptoms or signs of mesothelioma may not appear until 20 to 50 years (or more) after exposure to asbestos. Shortness of breath, cough, and pain in the chest due to an accumulation of fluid in the pleural space (pleural effusion) are often symptoms of pleural mesothelioma.[14]

Mesothelioma that affects the pleura can cause these signs and symptoms:[14]

In severe cases, the person may have many tumor masses. The individual may develop a pneumothorax, or collapse of the lung. The disease may metastasize, or spread to other parts of the body.

The most common symptoms of peritoneal mesothelioma are abdominal swelling and pain due to ascites (a buildup of fluid in the abdominal cavity). Other features may include weight loss, fever, night sweats, poor appetite, vomiting, constipation, and umbilical hernia.[15] If the cancer has spread beyond the mesothelium to other parts of the body, symptoms may include pain, trouble swallowing, or swelling of the neck or face.[citation needed]These symptoms may be caused by mesothelioma or by other, less serious conditions.

Tumors that affect the abdominal cavity often do not cause symptoms until they are at a late stage. Symptoms include:[citation needed]

Pericardial mesothelioma is not well characterized, but observed cases have included cardiac symptoms, specifically constrictive pericarditis, heart failure, pulmonary embolism, and cardiac tamponade. They have also included nonspecific symptoms, including substernal chest pain, orthopnea (shortness of breath when lying flat), and cough. These symptoms are caused by the tumor encasing or infiltrating the heart.[10]

In severe cases of the disease, the following signs and symptoms may be present:[citation needed]

If a mesothelioma forms metastases, these most commonly involve the liver, adrenal gland, kidney, or other lung.[16]

Working with asbestos is the most common risk factor for mesothelioma.[17] However, mesothelioma has been reported in some individuals without any known exposure to asbestos. Tentative evidence also raises concern about carbon-fibre nanotubes.[18][19]

The incidence of mesothelioma has been found to be higher in populations living near naturally occurring asbestos. People can be exposed to naturally occurring asbestos in areas where mining or road construction is occurring, or when the asbestos-containing rock is naturally weathered. Another common route of exposure is through asbestos-containing soil, which is used to whitewash, plaster, and roof houses in Greece.[12] In central Cappadocia, Turkey, mesothelioma was causing 50% of all deaths in three small villagesTuzky, Karain, and Sarhdr. Initially, this was attributed to erionite. Environmental exposure to asbestos has caused mesothelioma in places other than Turkey, including Corsica, Greece, Cyprus, China, and California.[12][20][21] In the northern Greek mountain town of Metsovo, this exposure had resulted in mesothelioma incidence around 300 times more than expected in asbestos-free populations, and was associated with very frequent pleural calcification known as Metsovo lung.[22][23]

The documented presence of asbestos fibers in water supplies and food products has fostered concerns about the possible impact of long-term and, as yet, unknown exposure of the general population to these fibers.[24]

Exposure to talc is also a risk factor for mesothelioma; exposure can affect those who live near talc mines, work in talc mines, or work in talc mills.[25]

In the United States, asbestos is considered the major cause of malignant mesothelioma[26] and has been considered "indisputably"[27] associated with the development of mesothelioma. Indeed, the relationship between asbestos and mesothelioma is so strong that many consider mesothelioma a signal or sentinel tumor.[28][29][30][31] A history of asbestos exposure exists in most cases.

Pericardial mesothelioma may not be associated with asbestos exposure.[10]

Asbestos was known in antiquity, but it was not mined and widely used commercially until the late 19th century. Its use greatly increased during World War II. Since the early 1940s, millions of American workers have been exposed to asbestos dust. Initially, the risks associated with asbestos exposure were not publicly known. However, an increased risk of developing mesothelioma was later found among naval personnel (e.g., Navy, Marine Corps, and Coast Guard), shipyard workers, people who work in asbestos mines and mills, producers of asbestos products, workers in the heating and construction industries, and other tradespeople. Today, the official position of the U.S. Occupational Safety and Health Administration (OSHA) and the U.S. EPA is that protections and "permissible exposure limits" required by U.S. regulations, while adequate to prevent most asbestos-related non-malignant disease, are not adequate to prevent or protect against asbestos-related cancers such as mesothelioma.[32] Likewise, the British Government's Health and Safety Executive (HSE) states formally that any threshold for exposure to asbestos must be at a very low level and it is widely agreed that if any such threshold does exist at all, then it cannot currently be quantified. For practical purposes, therefore, HSE assumes that no such "safe" threshold exists. Others have noted as well that there is no evidence of a threshold level below which there is no risk of mesothelioma.[33] There appears to be a linear, doseresponse relationship, with increasing dose producing increasing risk of disease.[34] Nevertheless, mesothelioma may be related to brief, low level or indirect exposures to asbestos.[27] The dose necessary for effect appears to be lower for asbestos-induced mesothelioma than for pulmonary asbestosis or lung cancer.[27] Again, there is no known safe level of exposure to asbestos as it relates to increased risk of mesothelioma.

The time from first exposure to onset of the disease, is between 25 and 70 years.[35] It is virtually never less than fifteen years and peaks at 3040 years.[27][36] The duration of exposure to asbestos causing mesothelioma can be short. For example, cases of mesothelioma have been documented with only 13 months of exposure.[37][38]

Exposure to asbestos fibers has been recognized as an occupational health hazard since the early 20th century. Numerous epidemiological studies have associated occupational exposure to asbestos with the development of pleural plaques, diffuse pleural thickening, asbestosis, carcinoma of the lung and larynx, gastrointestinal tumors, and diffuse malignant mesothelioma of the pleura and peritoneum. Asbestos has been widely used in many industrial products, including cement, brake linings, gaskets, roof shingles, flooring products, textiles, and insulation.[39]

Commercial asbestos mining at Wittenoom, Western Australia, took place from 1937 to 1966. The first case of mesothelioma in the town occurred in 1960. The second case was in 1969, and new cases began to appear more frequently thereafter. The lag time between initial exposure to asbestos and the development of mesothelioma varied from 12 years 9 months up to 58 years.[40] A cohort study of miners employed at the mine reported that 85 deaths attributable to mesothelioma had occurred by 1985. By 1994, 539 reported deaths due to mesothelioma had been reported in Western Australia.[citation needed]

Occupational exposure to asbestos in the United States mainly occurs when people are maintaining buildings that already have asbestos. Approximately 1.3 million US workers are exposed to asbestos annually; in 2002, an estimated 44,000 miners were potentially exposed to asbestos.[25]

Family members and others living with asbestos workers have an increased risk of developing mesothelioma, and possibly other asbestos-related diseases.[11][41][42] This risk may be the result of exposure to asbestos dust brought home on the clothing and hair of asbestos workers via washing a worker's clothes or coming into contact with asbestos-contaminated work clothing.[12][25] To reduce the chance of exposing family members to asbestos fibres, asbestos workers are usually required to shower and change their clothing before leaving the workplace.[citation needed]

Many building materials used in both public and domestic premises prior to the banning of asbestos may contain asbestos. Those performing renovation works or DIY activities may expose themselves to asbestos dust. In the UK, use of chrysotile asbestos was banned at the end of 1999. Brown and blue asbestos were banned in the UK around 1985. Buildings built or renovated prior to these dates may contain asbestos materials.[citation needed]

In a recent research carried on white American population in 2012, it was found that people with a germline mutation in their BAP1 gene are at higher risk of developing mesothelioma and uveal melanoma.[43]

Erionite is a zeolite mineral with similar properties to asbestos and is known to cause mesothelioma.[11] Detailed epidemiological investigation has shown that erionite causes mesothelioma mostly in families with a genetic predisposition.[12][20][21] Erionite is found in deposits in the Western United States, where it is used in gravel for road surfacing, and in Turkey, where it is used to construct homes. In Turkey, the United States, and Mexico, erionite has been associated with mesothelioma and has thus been designated a "known human carcinogen" by the US National Toxicology Program.[21]

In rare cases, mesothelioma has also been associated with irradiation of the chest or abdomen, intrapleural thorium dioxide (thorotrast) as a contrast medium, and inhalation of other fibrous silicates, such as erionite or talc.[11][25] Some studies suggest that simian virus 40 (SV40) may act as a cofactor in the development of mesothelioma.[25] This has been confirmed in animal studies,[44][45] but studies in humans are inconclusive.[44][46][47]

The mesothelium consists of a single layer of flattened to cuboidal cells forming the epithelial lining of the serous cavities of the body including the peritoneal, pericardial and pleural cavities. Deposition of asbestos fibers in the parenchyma of the lung may result in the penetration of the visceral pleura from where the fiber can then be carried to the pleural surface, thus leading to the development of malignant mesothelial plaques. The processes leading to the development of peritoneal mesothelioma remain unresolved, although it has been proposed that asbestos fibers from the lung are transported to the abdomen and associated organs via the lymphatic system. Additionally, asbestos fibers may be deposited in the gut after ingestion of sputum contaminated with asbestos fibers.[citation needed]

Pleural contamination with asbestos or other mineral fibers has been shown to cause cancer. Long thin asbestos fibers (blue asbestos, amphibole fibers) are more potent carcinogens than "feathery fibers" (chrysotile or white asbestos fibers).[27] However, there is now evidence that smaller particles may be more dangerous than the larger fibers. They remain suspended in the air where they can be inhaled, and may penetrate more easily and deeper into the lungs. "We probably will find out a lot more about the health aspects of asbestos from [the World Trade Center attack], unfortunately," said Dr. Alan Fein, chief of pulmonary and critical-care medicine at North Shore-Long Island Jewish Health System.[48]

Mesothelioma development in rats has been demonstrated following intra-pleural inoculation of phosphorylated chrysotile fibers. It has been suggested that in humans, transport of fibers to the pleura is critical to the pathogenesis of mesothelioma. This is supported by the observed recruitment of significant numbers of macrophages and other cells of the immune system to localized lesions of accumulated asbestos fibers in the pleural and peritoneal cavities of rats. These lesions continued to attract and accumulate macrophages as the disease progressed, and cellular changes within the lesion culminated in a morphologically malignant tumor.[citation needed]

Experimental evidence suggests that asbestos acts as a complete carcinogen with the development of mesothelioma occurring in sequential stages of initiation and promotion. The molecular mechanisms underlying the malignant transformation of normal mesothelial cells by asbestos fibers remain unclear despite the demonstration of its oncogenic capabilities (see next-but-one paragraph). However, complete in vitro transformation of normal human mesothelial cells to a malignant phenotype following exposure to asbestos fibers has not yet been achieved. In general, asbestos fibers are thought to act through direct physical interactions with the cells of the mesothelium in conjunction with indirect effects following interaction with inflammatory cells such as macrophages.[citation needed]

Analysis of the interactions between asbestos fibers and DNA has shown that phagocytosed fibers are able to make contact with chromosomes, often adhering to the chromatin fibers or becoming entangled within the chromosome. This contact between the asbestos fiber and the chromosomes or structural proteins of the spindle apparatus can induce complex abnormalities. The most common abnormality is monosomy of chromosome 22. Other frequent abnormalities include structural rearrangement of 1p, 3p, 9p and 6q chromosome arms.[citation needed]

Common gene abnormalities in mesothelioma cell lines include deletion of the tumor suppressor genes:[citation needed]

Asbestos has also been shown to mediate the entry of foreign DNA into target cells. Incorporation of this foreign DNA may lead to mutations and oncogenesis by several possible mechanisms:

Several genes are commonly mutated in mesothelioma, and may be prognostic factors. These include epidermal growth factor receptor (EGFR) and C-Met, receptor tyrosine kinases which are overexpressed in many mesotheliomas. Some association has been found with EGFR and epithelioid histology but no clear association has been found between EGFR overexpression and overall survival. Expression of AXL receptor tyrosine kinase is a negative prognostic factor. Expression of PDGFRB is a positive prognostic factor.[50] In general, mesothelioma is characterized by loss of function in tumor suppressor genes, rather than by an overexpression or gain of function in oncogenes.[51]

As an environmentally triggered malignancy, mesothelioma tumors have been found to be polyclonal in origin, by performing an X-inactivation based assay on epitheloid and biphasic tumors obtained from female patients.[52] These results suggest that an environmental factor, most likely asbestos exposure, may damage and transform a group of cells in the tissue, resulting in a population of tumor cells that are, albeit only slightly, genetically different.[53]

Asbestos fibers have been shown to alter the function and secretory properties of macrophages, ultimately creating conditions which favour the development of mesothelioma. Following asbestos phagocytosis, macrophages generate increased amounts of hydroxyl radicals, which are normal by-products of cellular anaerobic metabolism. However, these free radicals are also known clastogenic (chromosome-breaking) and membrane-active agents thought to promote asbestos carcinogenicity. These oxidants can participate in the oncogenic process by directly and indirectly interacting with DNA, modifying membrane-associated cellular events, including oncogene activation and perturbation of cellular antioxidant defences.[citation needed]

Asbestos also may possess immunosuppressive properties. For example, chrysotile fibres have been shown to depress the in vitro proliferation of phytohemagglutinin-stimulated peripheral blood lymphocytes, suppress natural killer cell lysis and significantly reduce lymphokine-activated killer cell viability and recovery. Furthermore, genetic alterations in asbestos-activated macrophages may result in the release of potent mesothelial cell mitogens such as platelet-derived growth factor (PDGF) and transforming growth factor- (TGF-) which in turn, may induce the chronic stimulation and proliferation of mesothelial cells after injury by asbestos fibres.[citation needed]

Diagnosis of mesothelioma can be suspected with imaging but is confirmed with biopsy. It must be clinically and histologically differentiated from other pleural and pulmonary malignancies, including reactive pleural disease, primary lung carcinoma, pleural metastases of other cancers, and other primary pleural cancers.[11]Primary pericardial mesothelioma is often diagnosed after it has metastasized to lymph nodes or the lungs.[10]

Diagnosing mesothelioma is often difficult because the symptoms are similar to those of a number of other conditions. Diagnosis begins with a review of the patient's medical history. A history of exposure to asbestos may increase clinical suspicion for mesothelioma. A physical examination is performed, followed by chest X-ray and often lung function tests. The X-ray may reveal pleural thickening commonly seen after asbestos exposure and increases suspicion of mesothelioma.[14] A CT (or CAT) scan or an MRI is usually performed. If a large amount of fluid is present, abnormal cells may be detected by cytopathology if this fluid is aspirated with a syringe.[10] For pleural fluid, this is done by thoracentesis or tube thoracostomy (chest tube); for ascites, with paracentesis or ascitic drain; and for pericardial effusion with pericardiocentesis. While absence of malignant cells on cytology does not completely exclude mesothelioma, it makes it much more unlikely, especially if an alternative diagnosis can be made (e.g., tuberculosis, heart failure).[citation needed] However, with primary pericardial mesothelioma, pericardial fluid may not contain malignant cells and a tissue biopsy is more useful in diagnosis.[10] Using conventional cytology diagnosis of malignant mesothelioma is difficult, but immunohistochemistry has greatly enhanced the accuracy of cytology.[citation needed]

Generally, a biopsy is needed to confirm a diagnosis of malignant mesothelioma. A doctor removes a sample of tissue for examination under a microscope by a pathologist. A biopsy may be done in different ways, depending on where the abnormal area is located. If the cancer is in the chest, the doctor may perform a thoracoscopy. In this procedure, the doctor makes a small cut through the chest wall and puts a thin, lighted tube called a thoracoscope into the chest between two ribs. Thoracoscopy allows the doctor to look inside the chest and obtain tissue samples. Alternatively, the chest surgeon might directly open the chest (thoracotomy). If the cancer is in the abdomen, the doctor may perform a laparoscopy. To obtain tissue for examination, the doctor makes a small incision in the abdomen and inserts a special instrument into the abdominal cavity. If these procedures do not yield enough tissue, an open surgical procedure may be necessary.[citation needed]

Immunohistochemical studies play an important role for the pathologist in differentiating malignant mesothelioma from neoplastic mimics, such as breast or lung cancer that has metastasized to the pleura. There are numerous tests and panels available, but no single test is perfect for distinguishing mesothelioma from carcinoma or even benign versus malignant. The positive markers indicate that mesothelioma is present; if other markers are positive it may indicate another type of cancer, such as breast or lung adenocarcinoma. Calretinin is a particularly important marker in distinguishing mesothelioma from metastatic breast or lung cancer.[11]

There are three main histological subtypes of malignant mesothelioma: epithelioid, sarcomatous, and biphasic. Epithelioid and biphasic mesothelioma make up approximately 75-95% of mesotheliomas and have been well characterized histologically, whereas sarcomatous mesothelioma has not been studied extensively. Most mesotheliomas express high levels of cytokeratin 5 regardless of subtype.[11]

Epithelioid mesothelioma is characterized by high levels of calretinin.[11]

Sarcomatous mesothelioma does not express high levels of calretinin.[11]

Other morphological subtypes have been described:

Staging of mesothelioma is based on the recommendation by the International Mesothelioma Interest Group.[54] TNM classification of the primary tumor, lymph node involvement, and distant metastasis is performed. Mesothelioma is staged IaIV (one-A to four) based on the TNM status.[54][55]

Mesothelioma can be prevented in most cases by preventing exposure to asbestos. The US National Institute for Occupational Safety and Health maintains a recommended exposure limit of 0.1 asbestos fiber per cubic centimeter.[25]

There is no universally agreed protocol for screening people who have been exposed to asbestos. Screening tests might diagnose mesothelioma earlier than conventional methods thus improving the survival prospects for patients. The serum osteopontin level might be useful in screening asbestos-exposed people for mesothelioma. The level of soluble mesothelin-related protein is elevated in the serum of about 75% of patients at diagnosis and it has been suggested that it may be useful for screening.[56] Doctors have begun testing the Mesomark assay, which measures levels of soluble mesothelin-related proteins (SMRPs) released by mesothelioma cells.[57]

Mesothelioma is generally resistant to radiation and chemotherapy treatment. Long-term survival and cures are exceedingly rare.[11] Treatment of malignant mesothelioma at earlier stages has a better prognosis. Clinical behavior of the malignancy is affected by several factors including the continuous mesothelial surface of the pleural cavity which favors local metastasis via exfoliated cells, invasion to underlying tissue and other organs within the pleural cavity, and the extremely long latency period between asbestos exposure and development of the disease. The histological subtype and the patient's age and health status also help predict prognosis. The epithelioid histology responds better to treatment and has a survival advantage over sarcomatoid histology.[58]

The effectiveness of radiotherapy compared to chemotherapy or surgery for malignant pleural mesothelioma is not known.[59]

Surgery, by itself, has proved disappointing. In one large series, the median survival with surgery (including extrapleural pneumonectomy) was only 11.7 months.[60] However, research indicates varied success when used in combination with radiation and chemotherapy (Duke, 2008), or with one of the latter. A pleurectomy/decortication is the most common surgery, in which the lining of the chest is removed. Less common is an extrapleural pneumonectomy (EPP), in which the lung, lining of the inside of the chest, the hemi-diaphragm and the pericardium are removed.[citation needed] In localized pericardial mesothelioma, pericardectomy can be curative; when the tumor has metastasized, pericardectomy is a palliative care option. The entire tumor is not often able to be removed.[10]

For patients with localized disease, and who can tolerate a radical surgery, radiation can be given post-operatively as a consolidative treatment. The entire hemithorax is treated with radiation therapy, often given simultaneously with chemotherapy. Delivering radiation and chemotherapy after a radical surgery has led to extended life expectancy in selected patient populations. It can also induce severe side-effects, including fatal pneumonitis.[61] As part of a curative approach to mesothelioma, radiotherapy is commonly applied to the sites of chest drain insertion, in order to prevent growth of the tumor along the track in the chest wall.[citation needed]

Although mesothelioma is generally resistant to curative treatment with radiotherapy alone, palliative treatment regimens are sometimes used to relieve symptoms arising from tumor growth, such as obstruction of a major blood vessel. Radiation therapy, when given alone with curative intent, has never been shown to improve survival from mesothelioma. The necessary radiation dose to treat mesothelioma that has not been surgically removed would be beyond human tolerance.[citation needed] Radiotherapy is of some use in pericardial mesothelioma.[10]

Chemotherapy is the only treatment for mesothelioma that has been proven to improve survival in randomised and controlled trials. The landmark study published in 2003 by Vogelzang and colleagues compared cisplatin chemotherapy alone with a combination of cisplatin and pemetrexed (brand name Alimta) chemotherapy in patients who had not received chemotherapy for malignant pleural mesothelioma previously and were not candidates for more aggressive "curative" surgery.[62] This trial was the first to report a survival advantage from chemotherapy in malignant pleural mesothelioma, showing a statistically significant improvement in median survival from 10 months in the patients treated with cisplatin alone to 13.3 months in the group of patients treated with cisplatin in the combination with pemetrexed and who also received supplementation with folate and vitamin B12. Vitamin supplementation was given to most patients in the trial and pemetrexed related side effects were significantly less in patients receiving pemetrexed when they also received daily oral folate 500mcg and intramuscular vitamin B12 1000mcg every 9 weeks compared with patients receiving pemetrexed without vitamin supplementation. The objective response rate increased from 20% in the cisplatin group to 46% in the combination pemetrexed group. Some side effects such as nausea and vomiting, stomatitis, and diarrhoea were more common in the combination pemetrexed group but only affected a minority of patients and overall the combination of pemetrexed and cisplatin was well tolerated when patients received vitamin supplementation; both quality of life and lung function tests improved in the combination pemetrexed group. In February 2004, the United States Food and Drug Administration approved pemetrexed for treatment of malignant pleural mesothelioma. However, there are still unanswered questions about the optimal use of chemotherapy, including when to start treatment, and the optimal number of cycles to give.[citation needed] Cisplatin and pemetrexed together give patients a median survival of 12.1 months.[11]

Cisplatin in combination with raltitrexed has shown an improvement in survival similar to that reported for pemetrexed in combination with cisplatin, but raltitrexed is no longer commercially available for this indication. For patients unable to tolerate pemetrexed, cisplatin in combination with gemcitabine or vinorelbine is an alternative, or vinorelbine on its own, although a survival benefit has not been shown for these drugs. For patients in whom cisplatin cannot be used, carboplatin can be substituted but non-randomised data have shown lower response rates and high rates of haematological toxicity for carboplatin-based combinations, albeit with similar survival figures to patients receiving cisplatin.[63] Cisplatin in combination with premetrexed disodium, folic acid, and vitamin B12 may also improve survival for people who are responding to chemotherapy.[64]

In January 2009, the United States FDA approved using conventional therapies such as surgery in combination with radiation and or chemotherapy on stage I or II Mesothelioma after research conducted by a nationwide study by Duke University concluded an almost 50 point increase in remission rates.[citation needed]

In pericardial mesothelioma, chemotherapy - typically adriamycin or cisplatin - is primarily used to shrink the tumor and is not curative.[10]

Treatment regimens involving immunotherapy have yielded variable results. For example, intrapleural inoculation of Bacillus Calmette-Gurin (BCG) in an attempt to boost the immune response, was found to be of no benefit to the patient (while it may benefit patients with bladder cancer). Mesothelioma cells proved susceptible to in vitro lysis by LAK cells following activation by interleukin-2 (IL-2), but patients undergoing this particular therapy experienced major side effects. Indeed, this trial was suspended in view of the unacceptably high levels of IL-2 toxicity and the severity of side effects such as fever and cachexia. Nonetheless, other trials involving interferon alpha have proved more encouraging with 20% of patients experiencing a greater than 50% reduction in tumor mass combined with minimal side effects.[citation needed]

Hyperthermic intrathoracic chemotherapy is used in conjunction with surgery,[65] including in patients with malignant pleural mesothelioma.[66] The surgeon removes as much of the tumor as possible followed by the direct administration of a chemotherapy agent, heated to between 40 and 48C, in the abdomen. The fluid is perfused for 60 to 120 minutes and then drained. High concentrations of selected drugs are then administered into the pleural cavity. Heating the chemotherapy treatment increases the penetration of the drugs into tissues. Also, heating itself damages the malignant cells more than the normal cells.[citation needed]

Multimodal therapy, which includes a combined approach of surgery, radiation or photodynamic therapy, and chemotherapy, is not suggested for routine practice for treating malignant pleural mesothelioma.[67] The effectiveness and safety of multimodal therapy is not clear (not enough research has been performed) and one clinical trial has suggested a possible increased risk of adverse effects.[67]

Large series of examining multimodality treatment have only demonstrated modest improvement in survival (median survival 14.5 months and only 29.6% surviving 2 years).[60] Reducing the bulk of the tumor with cytoreductive surgery is key to extending survival. Two surgeries have been developed: extrapleural pneumonectomy and pleurectomy/decortication. The indications for performing these operations are unique. The choice of operation namely depends on the size of the patient's tumor. This is an important consideration because tumor volume has been identified as a prognostic factor in mesothelioma.[68] Pleurectomy/decortication spares the underlying lung and is performed in patients with early stage disease when the intention is to remove all gross visible tumor (macroscopic complete resection), not simply palliation.[69] Extrapleural pneumonectomy is a more extensive operation that involves resection of the parietal and visceral pleurae, underlying lung, ipsilateral (same side) diaphragm, and ipsilateral pericardium. This operation is indicated for a subset of patients with more advanced tumors, who can tolerate a pneumonectomy.[70]

Mesothelioma often has a poor prognosis. Typical survival despite surgery is between 12 and 21 months depending on the stage of disease at diagnosis with about 7.5% of people surviving for 5 years.[71]

Women, young people, people with low-stage cancers, and people with epithelioid cancers have better prognoses.[11] Negative prognostic factors include sarcomatoid or biphasic histology, high platelet counts (above 400,000), age over 50 years, white blood cell counts above 15.5, low glucose levels in the pleural fluid, low albumin levels, and high fibrinogen levels. Several markers are under investigation as prognostic factors, including nuclear grade, and serum c-reactive protein. Long-term survival is rare.[50]

Pericardial mesothelioma has a 10-month median survival time.[10]

In peritoneal mesothelioma, high expression of WT-1 protein indicates a worse prognosis.[11]

Although reported incidence rates have increased in the past 20 years, mesothelioma is still a relatively rare cancer. The incidence rate varies from one country to another, from a low rate of less than 1 per 1,000,000 in Tunisia and Morocco, to the highest rate in Britain, Australia and Belgium: 30 per 1,000,000 per year.[72] For comparison, populations with high levels of smoking can have a lung cancer incidence of over 1,000 per 1,000,000. Incidence of malignant mesothelioma currently ranges from about 7 to 40 per 1,000,000 in industrialized Western nations, depending on the amount of asbestos exposure of the populations during the past several decades.[73] Worldwide incidence is estimated at 1-6 per 1,000,000.[11] Incidence of mesothelioma lags behind that of asbestosis due to the longer time it takes to develop; due to the cessation of asbestos use in developed countries, mesothelioma incidence is expected to decrease.[25] Incidence is expected to continue increasing in developing countries due to continuing use of asbestos.[11] Mesothelioma occurs more often in men than in women and risk increases with age, but this disease can appear in either men or women at any age. Approximately one fifth to one third of all mesotheliomas are peritoneal.[citation needed] Less than 5% of mesotheliomas are pericardial. The prevalence of pericardial mesothelioma is less than 0.002%; it is more common in men than women. It typically occurs in a person's 50s-70s.[10][74]

Between 1940 and 1979, approximately 27.5 million people were occupationally exposed to asbestos in the United States.[75] Between 1973 and 1984, the incidence of pleural mesothelioma among Caucasian males increased 300%. From 1980 to the late 1990s, the death rate from mesothelioma in the USA increased from 2,000 per year to 3,000, with men four times more likely to acquire it than women.[citation needed] More than 80% of mesotheliomas are caused by asbestos exposure.[11]

The incidence of peritoneal mesothelioma is 0.53.0 per million per year in men, and 0.22.0 per million per year in women.[76]

Mesothelioma accounts for less than 1% of all cancers diagnosed in the UK, (around 2,600 people were diagnosed with the disease in 2011), and it is the seventeenth most common cause of cancer death (around 2,400 people died in 2012).[77]

The connection between asbestos exposure and mesothelioma was discovered in the 1970s. In the United States, asbestos manufacture stopped in 2002. Asbestos exposure thus shifted from workers in asbestos textile mills, friction product manufacturing, cement pipe fabrication, and insulation manufacture and installation to maintenance workers in asbestos-containing buildings.[25]

Mesothelioma, though rare, has had a number of notable patients:

Although life expectancy with this disease is typically limited, there are notable survivors. In July 1982, Stephen Jay Gould, a well-regarded paleontologist, was diagnosed with peritoneal mesothelioma. After his diagnosis, Gould wrote "The Median Isn't the Message",[84] in which he argued that statistics such as median survival are useful abstractions, not destiny. Gould lived for another 20 years, eventually succumbing to cancer not linked to his mesothelioma.

Some people who were exposed to asbestos have collected damages for an asbestos-related disease, including mesothelioma. Compensation via asbestos funds or class action lawsuits is an important issue in law practices regarding mesothelioma.[citation needed]

The first lawsuits against asbestos manufacturers were in 1929. Since then, many lawsuits have been filed against asbestos manufacturers and employers, for neglecting to implement safety measures after the links between asbestos, asbestosis, and mesothelioma became known (some reports seem to place this as early as 1898). The liability resulting from the sheer number of lawsuits and people affected has reached billions of dollars.[85] The amounts and method of allocating compensation have been the source of many court cases, reaching up to the United States Supreme Court, and government attempts at resolution of existing and future cases. However, to date, the US Congress has not stepped in and there are no federal laws governing asbestos compensation.[86]In 2013, the "Furthering Asbestos Claim Transparency (FACT) Act of 2013" passed the US House of representatives and was sent to the US Senate, where it was referred to the Senate Judiciary Committee.[87] As the Senate did not vote on it before the end of the 113th Congress, it died in committee. It was revived in the 114th Congress, where it has not yet been brought before the House for a vote.[88]

The first lawsuit against asbestos manufacturers was brought in 1929. The parties settled that lawsuit, and as part of the agreement, the attorneys agreed not to pursue further cases. In 1960, an article published by Wagner et al. was seminal in establishing mesothelioma as a disease arising from exposure to asbestos.[89] The article referred to over 30 case studies of people who had suffered from mesothelioma in South Africa. Some exposures were transient and some were mine workers. Before the use of advanced microscopy techniques, malignant mesothelioma was often diagnosed as a variant form of lung cancer.[90] In 1962, McNulty reported the first diagnosed case of malignant mesothelioma in an Australian asbestos worker.[91] The worker had worked in the mill at the asbestos mine in Wittenoom from 1948 to 1950.[citation needed]

In the town of Wittenoom, asbestos-containing mine waste was used to cover schoolyards and playgrounds. In 1965, an article in the British Journal of Industrial Medicine established that people who lived in the neighbourhoods of asbestos factories and mines, but did not work in them, had contracted mesothelioma.[citation needed]

Despite proof that the dust associated with asbestos mining and milling causes asbestos-related disease, mining began at Wittenoom in 1943 and continued until 1966. In 1974, the first public warnings of the dangers of blue asbestos were published in a cover story called "Is this Killer in Your Home?" in Australia's Bulletin magazine. In 1978, the Western Australian Government decided to phase out the town of Wittenoom, following the publication of a Health Dept. booklet, "The Health Hazard at Wittenoom", containing the results of air sampling and an appraisal of worldwide medical information.[citation needed]

By 1979, the first writs for negligence related to Wittenoom were issued against CSR and its subsidiary ABA, and the Asbestos Diseases Society was formed to represent the Wittenoom victims.[citation needed]

In Leeds, England the Armley asbestos disaster involved several court cases against Turner & Newall where local residents who contracted mesothelioma demanded compensation because of the asbestos pollution from the company's factory. One notable case was that of June Hancock, who contracted the disease in 1993 and died in 1997.[92]

The WT-1 protein is overexpressed in mesothelioma and is being researched as a potential target for drugs.[11]

There are two high-confidence miRNAs that can potentially serve as biomarkers of asbestos exposure and malignant mesothelioma. Validation studies are needed to assess their relevance.[citation needed]

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Mesothelioma - Wikipedia

Mesothelioma – Symptoms and causes – Mayo Clinic

Overview

Malignant mesothelioma (me-zoe-thee-lee-O-muh) is a type of cancer that occurs in the thin layer of tissue that covers the majority of your internal organs (mesothelium).

Mesothelioma is an aggressive and deadly form of cancer. Mesothelioma treatments are available, but for many people with mesothelioma, a cure isn't possible.

Doctors divide mesothelioma into different types based on what part of the mesothelium is affected. Mesothelioma most often affects the tissue that surrounds the lungs (pleura). This type is called pleural mesothelioma. Other, rarer types of mesothelioma affect tissue in the abdomen (peritoneal mesothelioma), around the heart and around the testicles.

Mesothelioma care at Mayo Clinic

Signs and symptoms of mesothelioma vary depending on where the cancer occurs.

Pleural mesothelioma, which affects the tissue that surrounds the lungs, causes signs and symptoms that may include:

Peritoneal mesothelioma, which occurs in tissue in the abdomen, causes signs and symptoms that may include:

Signs and symptoms of other types of mesothelioma are unclear, since these forms of the disease are very rare.

Pericardial mesothelioma, which affects tissue that surrounds the heart, can cause signs and symptoms such as breathing difficulty and chest pains.

Mesothelioma of tunica vaginalis, which affects tissue surrounding the testicles, may be first detected as swelling or a mass on a testicle.

See your doctor if you have signs and symptoms that worry you. Signs and symptoms of mesothelioma aren't specific to this disease and, due to the rarity of mesothelioma, are more likely to be related to other conditions. If any persistent signs and symptoms seem unusual or bothersome, ask your doctor to evaluate them. Tell your doctor if you've been exposed to asbestos.

In general, cancer begins when a series of changes (mutations) happens in a cell's DNA. The DNA contains the instructions that tell a cell what to do. The mutations tell the cell to grow and multiply out of control. The abnormal cells accumulate and form a tumor.

It isn't clear what causes the initial genetic mutations that lead to mesothelioma, though researchers have identified factors that may increase the risk. It's likely that cancers form because of an interaction between many factors, such as inherited conditions, your environment, your health conditions and your lifestyle choices.

Most mesotheliomas are thought to be related to asbestos exposure. Asbestos is a mineral that's found naturally in the environment. Asbestos fibers are strong and resistant to heat, making them useful in a wide variety of applications, such as in insulation, brakes, shingles, flooring and many other products.

When asbestos is broken up, such as during the mining process or when removing asbestos insulation, dust may be created. If the dust is inhaled or swallowed, the asbestos fibers will settle in the lungs or in the stomach, where they can cause irritation that may lead to mesothelioma. Exactly how this happens isn't understood. It can take 20 to 60 years or more for mesothelioma to develop after asbestos exposure.

Most people with asbestos exposure never develop mesothelioma. This indicates that other factors may be involved in determining whether someone gets mesothelioma. For instance, you could inherit a predisposition to cancer or some other condition could increase your risk.

Factors that may increase the risk of mesothelioma include:

As pleural mesothelioma spreads in the chest, it puts pressure on the structures in that area. This can cause complications, such as:

Reducing your exposure to asbestos may lower your risk of mesothelioma.

Most people with mesothelioma were exposed to the asbestos fibers at work. Workers who may encounter asbestos fibers include:

Ask your employer whether you have a risk of asbestos exposure on the job.

Follow all safety precautions in your workplace, such as wearing protective equipment. You may also be required to shower and change out of your work clothes before taking a lunch break or going home. Talk to your doctor about other precautions you can take to protect yourself from asbestos exposure.

Older homes and buildings may contain asbestos. In many cases, it's more dangerous to remove the asbestos than it is to leave it intact. Breaking up asbestos may cause fibers to become airborne, where they can be inhaled. Consult experts trained to detect asbestos in your home. These experts may test the air in your home to determine whether the asbestos is a risk to your health. Don't attempt to remove asbestos from your home hire a qualified expert.

Jan. 15, 2019

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Mesothelioma - Symptoms and causes - Mayo Clinic

Mesothelioma Causes, Symptoms, Treatment & Prognosis

Mesothelioma facts

What is mesothelioma?

Mesothelioma is a rare form of cancer (malignancy) that most frequently arises from the cells lining the sacs of the chest (the pleura) or the abdomen (the peritoneum). Pleural mesothelioma is the most common form, often becoming apparent with symptoms in the chest area such as chest pain, cough, and/or shortness of breath. Shortness of breath often occurs due to a large pleural effusion (fluid in the thoracic cavity). Peritoneal mesothelioma is much less common. This can affect the organs in the abdomen, and its symptoms are related to this area of the body, that is, abdominal swelling, nausea, vomiting, and bowel obstruction. The rarest form of mesothelioma is pericardial mesothelioma, which involves the sac surrounding the heart.

There are two major cell types of mesothelioma, epithelial and sarcomatoid. Sometimes both of these cell types can be present, also referred to as biphasic. The sarcomatoid type is rarer and occurs in only about 15% of cases; it portends a poorer prognosis. In very rare cases, mesothelioma can originate from benign, non-malignant cells. Surgery cures this so-called benign mesothelioma.

There are many causes of chest pain. A serious form of chest pain is angina, which is a symptom of heart disease and results from inadequate oxygen supply to the heart muscle. Angina can be caused by coronary artery disease or spasm of the coronary arteries. Chest pain can also be due to a heart attack (coronary occlusion), aortic aneurysm dissection, myocarditis, esophageal spasm, esophagitis, rib injury or disease, anxiety, and other important diseases. Do not try to ignore chest pain and "work (or play) through it." Chest pain is a warning to seek medical attention.

What are mesothelioma symptoms?

Most people present with complaints of shortness of breath. They also can have complaints of chest pain and cough. Patients may also be asymptomatic, with the disease discovered by physical exam or an abnormal chest X-ray.

As the disease progresses, shortness of breath increases, and weight loss, decreased appetite, and night sweats can develop. Local invasion by the tumor can result in changing of voice, loss of function of the diaphragm, and symptoms specific to the area and involvement of adjacent structures.

What causes mesothelioma?

Most people with malignant mesothelioma have worked on jobs where they breathed asbestos. Usually, this involves men over 40 years of age. Others have been exposed to asbestos in a household environment, often without knowing it. The number of new cases of mesothelioma has been relatively stable since 1983, the same time that the U.S. Occupational Safety and Health Administration (OSHA) instituted restrictions on asbestos. In Europe, the number of new cases of mesothelioma continues to rise.

How much asbestos exposure does it take to get mesothelioma?

An exposure of as little as one or two months can result in mesothelioma 30 or 40 years later and in some cases, as much as 70 years later.

How long does it take after asbestos exposure for mesothelioma to show up?

People exposed in the 1940s, '50s, '60s, and '70s are now being diagnosed with mesothelioma because of the long latency period of asbestos disease.

How do health care professionals diagnose mesothelioma?

Pathological examination from a biopsy diagnoses mesothelioma. A health care professional removes tissue. Then a pathologist places it under a microscope and makes a definitive diagnosis and issues a pathology report. This is the end of a process that usually begins with symptoms that send most people to the doctor: a fluid buildup around the lungs (pleural effusions), shortness of breath, pain in the chest, or pain or swelling in the abdomen. The doctor may order an X-ray or CT scan of the chest or abdomen. If further examination is warranted, the following tests may be done:

What is the prognosis for mesothelioma?

Like most cancers, the prognosis for this disease often depends on how early it is diagnosed and how aggressively it is treated. Unfortunately, oftentimes health care professionals find mesothelioma at a stage in which a cure is unobtainable. Many will succumb to the disease within one year of diagnosis.

Treatment options are determined by the stage of mesothelioma (the extent to which the tumor has spread in the body). There are three staging systems currently in use, and each one measures somewhat different variables.

The oldest staging system and the one most often used is the Butchart system, based mainly on the extent of primary tumor mass and divides mesotheliomas into four stages.

The more recent TNM system considers variables of tumor in mass and spread, lymph node involvement, and metastasis.

TNM system: variables of T (tumor), N (lymph nodes), and M (metastasis)

The Brigham system is the latest system and stages mesothelioma according to resectability (the ability to remove the tumor surgically) and lymph node involvement.

What is the treatment for mesothelioma?

There are three traditional kinds of treatment for patients with malignant mesothelioma. Often physicians combine two or more of these in the course of treatment:

Surgery: There are several types of surgery used in treating mesothelioma.

Radiation therapy uses high-energy X-rays to kill cancer cells and shrink tumors. Radiation may come from a machine outside the body (external radiation therapy) or from putting materials that produce radiation (radioisotopes) through thin plastic tubes in the area where the cancer cells are (internal radiation therapy).

If fluid has collected in the chest or abdomen, your doctor may drain the fluid out of your body by putting in a needle into the chest or abdomen and using gentle suction to remove the fluid. If a doctor removes fluid from the chest, this is called thoracentesis. If a physician removes fluid from the abdomen, this is called paracentesis. Your doctor may also put drugs through a tube into the chest to prevent more fluid from accumulating.

Health care professionals administer adjuvant radiation in a manner to avoid exposure of the opposite lung to radiation and its potential side effects.

Chemotherapy is the use of drugs to kill cancer cells. Health care professionals administer chemotherapy by pill, or it may be put into the body by a needle in the vein or muscle. Often, a platinum-based chemotherapy (cisplatin or carboplatin) drug is given along with a second agent, pemetrexed. The side effects can be quite toxic, therefore they are used in people who are physically well enough to tolerate these side effects.

Chemotherapeutic agents can be administered either systemically (through the bloodstream) or intrapleurally (in the pleural cavity). When it is administered intrapleurally, the treatment is localized at the site of the tumor. These drugs are generally very toxic and you should discuss their use very carefully with your physician.

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Is there any promising research or are there promising drugs for mesothelioma?

Medical researchers are testing new approaches to treat malignant mesothelioma. They often combine traditional treatments or include something entirely new. They include:

Research is being conducted at various cancer centers all over the United States.

A recent study involving L-NDDP produced two cases of remission in mesothelioma patients. Another study found that a drug known as lovastatin might hold promise for mesothelioma patients.

To learn more about mesothelioma clinical studies and journal medical journal articles, visit the Mesothelioma Web (http://www.mesotheliomaweb.org).

What other kinds of information is available for people with mesothelioma?

There are numerous cancer web sites, some specific to mesothelioma. Because they are often difficult to locate, we have listed some relevant medical web sites that have information about mesothelioma.

American Institute for Cancer Research(http://www.aicr.org)

American Thoracic Society(http://www.thoracic.org/)

Canadian Cancer Society(http://www.bc.cancer.ca)

Mesothelioma Web(http://www.mesotheliomaweb.org)

References

Mujoomdar, A.A., and D.J. Sugarbaker. "Hyperthermic Chemoperfusion for the Treatment of Malignant Pleural Mesothelioma." Semin Thorac Cardiovasc Surg 20.4 Winter 2008: 298-304.

Ried, Michael, et al. "Cytoreductive surgery and hyperthermic intrathoracic chemotherapy perfusion for malignant pleural tumours: perioperative management and clinical experience." Eur J Cardio-thoracic Surgery 43.4 April 2013: 801-807.

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Mesothelioma Causes, Symptoms, Treatment & Prognosis

US Navy Veterans Mesothelioma Advocate Urges the Family of a Retired Navy Officer or NCO Who Now has Mesothelioma to Call Attorney Erik Karst of Karst…

HOUSTON, Aug. 13, 2020 /PRNewswire/ --The US Navy Veterans Mesothelioma Advocate says, "We are appealing to the family of a retired career Navy officer or NCO anywhere in the nation who has just been diagnosed with mesothelioma to get serious about financial compensation and to call attorney Erik Karst of the law firm of Karst von Oiste at 800-714-0303. Erik Karst is one of the nation's leading mesothelioma attorneys and he specializes in assisting Navy Veterans with mesothelioma. Mesothelioma compensation for a person like this could be in the millions of dollars because their asbestos exposure may have been so extreme.

"Attorney Erik Karst of the law firm of Karst von Oiste and his remarkable colleagues have been assisting Navy Veterans with mesothelioma for decades and they are responsible for over a billion dollars in financial compensation for people like this. Erik Karst is also extremely familiar with navy ships, submarines, and shipyards. Having this type of knowledge is a huge advantage because Erik Karst will be able to talk specifics with a Navy Veteran about how, where and when they were exposed to asbestos. It is this information that becomes the basis for a mesothelioma compensation claim. For direct access to attorney Erik Karst of Karst von Oiste please call 800-714-0303 anytime. You will be glad you did."www.karstvonoiste.com/

The US Navy Veterans Mesothelioma Advocate is urging the family of a retired Navy Officer or NCO who has recently diagnosed mesothelioma to not start playing lawyer roulette on the Internet by calling on ads that mention 'free' booklets, calculators, no law suit needed-because if they call on one of these ads-they might create a lawyer stampede.

The average age of a person with mesothelioma in the United States is 72 years old and by the time they get diagnosed they are typically extremely sick. "We want all Navy Veterans who have mesothelioma to receive the best possible compensation results-and we are certain attorney Erik Karst and his amazing team at Karst von Oiste will deliver. For direct access to attorney Erik Karst of Karst von Oiste please call 800-714-0303."www.karstvonoiste.com/

According to the CDC the states indicated with the highest incidence of mesothelioma include Maine, Massachusetts, Connecticut, Maryland, New Jersey, Pennsylvania, Ohio, West Virginia, Virginia, Michigan, Illinois, Minnesota, Louisiana, Washington, and Oregon.

However, based on the calls the US Navy Veterans Mesothelioma Advocate receives a US Navy Veteran who has been diagnosed with mesothelioma could live in any state including New York, Florida, California, Texas, Ohio, Iowa, Indiana, Missouri, North Carolina, Kentucky, Tennessee, Georgia, Alabama, Oklahoma, Arkansas, Kansas, Nebraska, North Dakota, Wyoming, Nevada, Colorado, New Mexico, Utah, Arizona, Idaho, or Alaska.www.karstvonoiste.com/

For a listing of all types of current and past US Navy warships please review the US Navy website on this topic:https://www.navy.mil/navydata/our_ships.asp

For more information about mesothelioma, please refer to the National Institutes of Health's web site related to this rare form of cancer:https://www.cancer.gov/types/mesothelioma

Media Contact:

Michael Thomas800-714-0303242066@email4pr.com

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US Navy Veterans Mesothelioma Advocate Urges the Family of a Retired Navy Officer or NCO Who Now has Mesothelioma to Call Attorney Erik Karst of Karst...


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