Longevity Fund raises cash to back anti-aging startups | FierceBiotech – FierceBiotech

Longevity Fund has raised $22 million to make a fresh wave of investments in companies working to treat age-related diseases. The financing positions Laura Deming,who started work on the fund before turning 18, to follow up on the bets she has already placed on companies such as Unity Biotechnology.

The new fund is small in size compared to many of todays biotech investment vehicles. But the track record of Demings first, $4 million fund suggests the MIT dropout and her team will use the money to make investments in companies worth keeping tabs on.

Longevity Fund has invested in five companies to date. The portfolio includes Unity, an anti-aging startup that extended its series B round last week to bring the total up to $151 million. Longevity Fund also participated in a $25.6 million series A in Precision BioSciences, which went on to pen an immuno-oncology pact with Baxalta and committed cash to Metacrine before Novo Nordisk took up an option on its FGF1 program. 2014 Fierce 15 company Navitor is also in the portfolio.

Deming plans to use the new money to invest in eight to 10 companies, suggesting the fund will continue to place relatively small bets. That partly reflects the funds desire to act as much as a bridge to other investors as a source of capital itself. And, when it comes to drumming up interest in anti-aging startups, Deming thinks things will be easier than back when the first fund got going in 2011.

Earlier, our biggest challenge was getting other investors on board and convincing them that aging has become a place to play. Now thats a nonissue, which is great. Our job is to help the companies get other investors on board, so its wonderful to see excitement in the space begin to build, Deming told TechCrunch.

Deming was years ahead of the uptick in interest in anti-aging research. More than a decade ago, aged 11, Deming wrote to Cynthia Kenyon, Ph.D., the molecular biologist (and one of FierceBiotech's "Top women in biopharma 2015") who was one of the first people Art Levinson, Ph.D., and Hal Barron, M.D., hired to work at Googles anti-aging offshoot Calico. Deming asked to visit Kenyons lab at UCSF. A year later, Deming was working at the lab on research into how genetic and environmental changes alter lifespans.

That led Deming, via a spell at MIT, to a fellowship program set up by Peter Thiel that gave her the chance to found Longevity Fund. Six years later, Demings interest in anti-aging looks prescient and the fund is equipped to step up its activities.

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Former Minnesota Vikings RB Adrian Peterson repeating his big claims of longevity, success – Scout

Adrian Peterson is repeating his legendary big claims of playing for years and setting records to a fresh audience in New Orleans.

Everything old is new again for former Minnesota Vikings running back Adrian Peterson.

For those of us familiar with the unrealistic athletic psyche of Peterson, weve heard these refrains before.

My goal is to rush for 2,500 yards.

I can play until Im 40.

I dont pay attention to the outside noise about age.

All of them have been part of the Peterson presentation for the last several years and, to his credit, when people have counted him out prematurely, he has shoved their negativity right down their throats with aggression.

Coming off his Christmas Eve ligament shredding in 2011, the conventional wisdom was that even elite players dont recover from that kind of injury.

Peterson proved them wrong, coming within a couple more carries of setting the all-time single-season rushing record. His detractors had nowhere to run and nowhere to hide.

When he was shut down in 2014 while litigating child abuse charges, Peterson was again dismissed as never being his dominant self again driven by the 24/7 nature of sports these days with no accountability to defend your short-term hot takes. It can be argued he showed up at Vikings OTAs only after being summarily disrespected by the leagues Top 100 NFL Network projection for players voted on by fellow players that put Peterson behind journeyman RB Justin Forsett.


Coincidence? Dont bet on it.

The claims of longevity combined with production have surfaced again.

Its a good number, the 32-year-old Peterson saidwhen asked about playing five more years. Approaching 40.

As he has gotten older and has to work harder behind the scenes to maintain his athletic dominance, Peterson has spit in the eye of Father Time. What has applied to just about everyone else, doesnt apply to A.D.

All Day means all day.

Id be lying to you say it doesnt give you a chip [on your shoulder]. Especially being a competitor," Peterson said, according to the New Orleans Advocate. "Its not my main focus. Its something that drives you a little bit. After 30, because it was the same back then. Oh, hes 30. Then I ended up leading the league in 2015. Same thing the next year. Stuff will continue to repeat itself until I finish.

History will remember Peterson in the conversation as G.O.A.T. among running backs.

As one can presumably think, Paul Bunyan moved on from Minnesota. So did the stories associated with him tall tales that included some truth to them, but legends that are difficult to quantify.

In New Orleans, a city that is no stranger to larger-than-life characters, Petersons predictions and prognoses have found a new audience unfamiliar with the outrageous claims that have become so familiar to Vikings fans.

Welcome to the Big Easy, Adrian, where everything old is suddenly new again.

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Former Minnesota Vikings RB Adrian Peterson repeating his big claims of longevity, success - Scout

Fred From's secret to longevity: don't worry, be happy – Gatton Star

BUARABA'S Fred From says the secret to a long and happy life is to keep active, be happy and to not worry.

Mr From was living proof of his own advice as he celebrated his 100th birthday on May 30. And in a display of his full and fortunate life more than 150 people turned out to celebrate his milestone birthday at Forest Hill Hall.

The ex-farmer, army officer, environmentalist and academic revealed he had always tried to lead a healthy life.

"I always played sports - like football and never smoked - if anything helped me that would have been the thing, he said.

"I don't feel any different turning 100.

Born in a military hospital in Brisbane, Mr From grew up and attended school in Lowood.

"I've lived in the Lockyer practically all my life - except when I joined the army for four years in the Second World War, Mr From said.

"I was 23 years old.

"I served in Cyprus, New Guinea, Egypt and later in Korea - after Korea I came back and went to the university to study agriculture.

"I studied there for six months, then I married Lola Brimblecombe.

Over many years, Mr From farmed cattle, grapes, watermelon and sweet potato on his Burarbra farm.

Later on, Mr From became heavily involved in agriculture and the environment and helped to set up an environmental reserve with some friends when Atkinson Dam was constructed in the early 1970s.

In the year 2000 he was awarded an Order of Australia for his extensive work in agriculture.

Mr From said he had been blessed with a fortunate life.

"I've had a happy family and social life, he said.

"I recieved a letter from the Queen and several other dignitaries, it was wonderful.

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Fred From's secret to longevity: don't worry, be happy - Gatton Star

SCOR expands EMEA longevity risk capabilities with new appointment – Reinsurance News (registration)

6th June 2017 - Author: Luke Gallin

French insurer and reinsurer SCOR has announced the appointment ofseasoned longevity risk transfer executive,Wolfgang Murmann, as itsnewHead of Longevity for Europe, the Middle East and Africa (EMEA).

The appointment ofMurmann, who has a solid track record in longevity risk transfer markets and joins from asset management firm, Insight Investment, will enable SCOR to expand its coverage forthe continental European longevity risk transfer and reinsurance marketplace.

While at Insight Investment he focused on solutions for pensions and institutions, and time spent at bothCommerzbank AG andDresdner Kleinwort also grew his experience and knowledge in the sector.

Longevity risk is seen as one of the growth areas in the reinsurance market, with pension schemes increasingly looking to hedge their growing longevity exposure, essentially protecting themselves against the exposure ofcohorts living longer than initially anticipated.

SCOR has participated in a number of large longevity risk transactions over the years, acting as botha lead reinsurance provider and alsomore traditionally structured longevity reinsurance arrangements inmore recent times. The expansion of its longevity team should enable the re/insurer to increase its presence in the European longevity risk transfer market.

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FSU researchers receive $2.8 million grant to search for the origin of personality traits impacting longevity – Florida State News

Angelina Sutin, assistant professor in the department of behavioral sciences and social medicine, has received a $2.8 million grant from the National Institutes of Health.

Our personality predicts more than just the type of friends we may have. It also provides significant clues about our health and can even predict how long we might live.

Yet little is known about how our personality forms relative to what we know about its consequences on health across the lifespan.

Florida State University College of Medicine Assistant Professor Angelina Sutin is seeking answers with the help of a $2.8 million National Institutes of Health grant.

As part of a five-year study, her team will work to identify prenatal and childhood neighborhood risk factors contributing to the development of personality traits most consequential for healthy aging. A better understanding of these relationships is the first step toward earlier interventions for improving health outcomes.

A number of biological, social and behavioral influences affect pregnancy. Did the mother smoke, drink, use drugs, suffer from depression or experience physical or mental abuse?

In childhood, similar influences vary from child to child depending on where they lived and the relative socioeconomic factors in play.

The broader goal is to understand where personality comes from in childhood to have a better sense of how we could intervene, Sutin said. One thing we are looking at, for example, is what factors might be involved in helping some kids to be more resilient than others.

Sutin plans to integrate three established frameworks of health research addressing those factors into one theoretical model examining the influences on formation of personality and the eventual health consequences. She will be assisted by FSU College of Medicine faculty researchers from the departments of behavioral sciences and social medicine, biomedical sciences and geriatrics.

The research centers on three longtime behavioral and biological health studies conducted in the United States, United Kingdom and Australia. The studies, involving thousands of participants assessed over a span of several decades, look at risk factors ranging from prenatal health to childhood place of residence.

The U.S. study will allow Sutin to look more closely at relative neighborhood safety, family income and education and potential links with health outcomes.

Even though the participants in these studies are from three completely different cultural contexts, if you grow up in vulnerable circumstances, regardless of where it is, its still vulnerable circumstances, Sutin said. Were going to be able to look at that in early childhood with the Australian and the English data, young adulthood in the English data and middle adulthood into old age with the U.S. data.

Leslie Beitsch, chair of the department of behavioral sciences and social medicine, said Sutin is renowned for her exceptional research.

Dr. Sutins work is often cited in the lay press but is even more influential within health psychology academic circles, and its easy to understand why, Beitsch said. Projects like this offer the potential to unlock new therapeutic pathways that enable people to experience more optimal health across the life course.

Sutin, College of Medicine Associate Professor of Geriatrics Antonio Terracciano and others have published research showing that those who show more conscientiousness generally experience better health outcomes and greater longevity. Neuroticism leads in the other direction.

Managing health behaviors associated with conscientiousness and neuroticism, then, could be an effective intervention to address health problems.

In the ongoing study, Sutin hopes to gain understanding about how these traits emerge, potentially leading to new ways of mitigating unwanted behaviors linked to personality.

This project really began with thinking about where personality traits come from, she said. It makes more sense to intervene at the source rather than later in life.

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FSU researchers receive $2.8 million grant to search for the origin of personality traits impacting longevity - Florida State News

Last chance to complete Ram Longevity survey (From The Scottish … – The Scottish Farmer

PROMPTED by claims from members that rams do not work on commercial farms for as many seasons as wanted, commercial sheep farmers in the UK are being urged to take part in an online survey to indicate how long rams are lasting in their flocks.

NSA is facilitating a group of experts to investigate the flock life of breeding males and reasons for deaths and culling in the UK. One of that team, independent sheep consultant Lesley Stubbings, said: There is currently no data on ram longevity or how much each one costs. Estimates vary widely from 1/lamb sired to more than 7/lamb.

We need to find out exactly what is happening on farms and investigate the main reasons for early culling and death. Then we can suggest ways of improving ram life and productivity. More than 600 sheep farmers have taken part in the online survey so far, but we would like another 100 or so by the closing date in June.

There will be opportunities to do the survey on the NSA stand at NSA Highland Sheep at Kinnahaird Farm, Strathpeffer next Wednesday, May 31, and at NSA North Sheep, at West Shields Farm, Tow Law, County Durham on Wednesday June 7.

All responses remain anonymous, but the survey does take the first part of the postcode so that geographic spread can be deduced. The online survey, which closes on Friday June 16, can be accessed at http://www.surveymonkey.co.uk/r/ramlongevity and will take just a few minutes to fill in.

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Last chance to complete Ram Longevity survey (From The Scottish ... - The Scottish Farmer

The curse of IT longevity – ComputerWeekly.com

Lots has been written about the WannaCry ransomware by experts and non-experts alike. And with good reason. With so many organisations affected across the world, including high profile victims such as the NHS, its no wonder people have concentrated so much attention on the threat posed by WannaCry and other forms of ransomware.

Digital transformation is a phrase that means many things to many people but for it to have any real relevance to the channel then it needs to mean a chance to make money. This guide will share some of the recent developments in the channel and the latest thoughts about the issue.

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Amid all the outcry over WannaCry, one of the most persistent messages has been the condemnation of affected organisations for continuing to use an operating system (Windows XP) which, in IT terms, is damn near medieval. Its nearly 16 years old!

In an industry that takes great pride in the speed with which it evolves and innovates, thats a seriously long time. Many technologies have come and gone since Microsoft released XP to manufacturing in August 2001. And theres no doubt that Microsoft has been trying its hardest to wean customers away from the OS for several years now.

But XP users (and people looking in from the outside) might be forgiven for suspecting that the IT world views longevity as a curse rather than a sign of durability. And you can see why IT vendors might feel that way. Having to patch and maintain older products after they have moved onto the next big thing in our rapidly evolving industry is a burden that many IT vendors just dont want to have to shoulder if they can help it.

But while its understandable, it also serves to highlight the disadvantages of the industrys strategy of making a virtue of how fast moving it is. On one level, it shows that despite all the boasts, there are still plenty of bits of IT infrastructure that are vulnerable to attacks because they have been left behind as the industry has relentlessly pursued one next big thing after the other. XP is many next big things behind.

In addition, if vendors seek to implement rapid changes in technologies, there is less chance for any technology to enjoy the benefits of maturity where vendors and customers can finally enjoy a period of stability before the next disruptive phase begins.

Theres also a feeling that, despite all this talk of the fast pace of change, vendors have frequently indulged in change for changes sake to coerce customers into upgrading their IT equipment more often than they have to. This process of incessant change means the IT infrastructure of many organisations is threaded through with remnants of older technologies. Those technologies create vulnerabilities, although it could be argued they might be unsafe not because of their age but because of vendor indifference to their maintenance and preservation.

In other words, the rapid pace of evolution in IT creates an environment where vulnerabilities can flourish because vendors are able to move onto the next innovation before anyone can force them to shoulder full responsibility for their earlier technologies.

The industry has a habit of urging customers to upgrade for fear of falling behind but you could just as easily argue that theyre doing it for their own benefit. If customers dont upgrade quickly enough, vendors might have to spend more time supporting their existing product instead of replacing it with another one. Ironically, it is precisely because of this policy of permanent revolution that organisations are often left vulnerable to attack via their continued use of technologies that have never been properly maintained by the vendors.

After all, if youre constantly moving forwards, you never have to look back.

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The curse of IT longevity - ComputerWeekly.com

Social Security Knowledge Center: What does longevity have to do … – Northeast Mississippi Daily Journal

According to the 2015 Social Security report, less than 7 percent of people with enough quarters to draw their Social Security benefit died prior to receiving. There are three other groups of individuals that will not receive benefits infrequent workers who do not have sufficient earnings to qualify for benefits, non-covered workers such as state and local government employees who did not pay into the program and immigrants who arrive in the United States at 50 or older and therefore have not worked long enough to qualify for benefits.

Benefits are affected by how long you live, which is changing with every new breakthrough in the medical field. Life expectancy data is changing as well one of every four 65 years olds will live past age 90. The average life expectancy in the U.S. for men is 85 years old and for women, it is 88 years old. As we talk to clients, most people are more concerned about dying early, than living too long. This is a mindset that needs to be discussed.

As you get older, the cost of medical expenses increases. That is why it is so important when looking at your Social Security benefit, to have a professional present options that will improve your Survivor benefit. When one member of a married couple dies, only one check is remaining the higher of the two. So, it only makes sense to try and improve this benefit. Statistically, women outlive men so, you are looking at years of additional income needed for the spouse, that is now compromised by receiving only one check, not two. Thats a big difference.

Therefore, we tell people they need a plan Social Security should not be taken just because you are entitled to receive it. When, how and why need to be factored into your decision.

Roy and Diane Thompson are both National Social Security Advisors, and Roy is a former CPA of 40 years. The couple lives in Corinth and can be reached at (601) 954-0699 or at dthompson@pillarsllc.com. For more information, visit http://www.pillarsllc.com.

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Social Security Knowledge Center: What does longevity have to do ... - Northeast Mississippi Daily Journal

Underheralded The Damned is far from cursed when it comes to … – Burlington County Times

No one can blame Dave Vanian for being bummed out about his band the Damned being overlooked.

The only consolation is that many recording artists, the Dambuilders, the Posies and Redd Kross, just to name a few, never scored deserved attention.

But thats how it goes in the music world. The Damned is one of those acts that has received the shortest straw over the years. The British band emerged the same year, 1976, as the much more celebrated Sex Pistols. The Damned caused a stir with its initial hit, The New Rose, but other British acts such as the Clash and Motorhead attracted a larger fan base.

I never understood it, Vanian said. The Damned have been so overlooked.

Vanian is correct but the silver lining is that, unlike the Clash, Sex Pistols and Motorhead, the Damned still exist four decades after the group formed in London. The act, with its fast-paced sonics and its edgy attitude, is not just a seminal punk act but it has also impacted the Goth world with Vanians dark lyrics and vampiric costumes.

Weve heard again and again over the years that weve influenced bands, Vanian said. Thats great but whats most significant is making the fans happy. Were a working band. Being in this band enables us to make a living doing what we love.

The Damned, which will perform Sunday at the Theatre of Living Arts, is on its 40th anniversary tour. Vanian, a singer with a commanding presence, is proud of the fact that his band has never compromised.

We do everything on our own terms, Vanian said. We couldnt do it any other way. I would rather struggle and do what I want to do artistically rather than creating something simply because it might make us money.

Ten albums and nine singles that cracked the UK Singles Chart Top 40 is impressive. Weve never given up, he said. Were always thinking that we can still be successful when it comes to new songs. It helped that we had some success. We know what were capable of. I love looking back on what we accomplished.

Vanian doesnt sound like anyone else with his croon, which is punctuated by his creepy theatrical approach.

When it comes to making music and playing live, its work but its a great time, Vanian said. Weve always put so much effort into the live shows. We try to make great albums. With (guitarist) Captain Sensible playing like he does, theres always hope that well make some great pop songs. He and I work really well together. I love being in a band with him.

The Damned, which also includes keyboardist Monty Oxymoron, bassist Stu West and drummer Pinch, is looking ahead after all of this time.

We still believe that we can come up with some great material, Vanian said. We have a future but we dont ignore the past when we perform. The fans appreciate what we do and I appreciate that they have stayed with us all of these years. We never became this massive band but there is something cool about being able to stay together doing this all these years.

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Underheralded The Damned is far from cursed when it comes to ... - Burlington County Times

Cook Medical, Indiana Limestone among local business recognized for longevity – The Herald-Times (subscription)

Cook Medical, Indiana Limestone Co., Cassady Electric and Bright & Williamson Insurance Agency were recognized among the 34 Indiana businesses to receive the Governors Century or Half Century Business Award this year.

Two businesses in Monroe County were recognized for their longevity and service to their employees, community and the state. Cassady Electric and Cook Medical were founded 52 and 54 years ago, respectively. In Lawrence County, Indiana Limestone Co. was recognized for 91 years of service. Brown County's Bright & Williamson Insurance Agency was recognized for its 96 years in service.

"I am thrilled to celebrate this year's honorees and their integral role in building one of the nation's best business climates," Gov. Eric Holcomb said in a press release. "Together, I'm confident we will continue to take Indiana to the next level, ensuring Indiana is the best place to start a business, grow a business and get a job."

According to a release from the Indiana Economic Development Corp., the award has recognized more than 1,400 companies from across Indiana over its 26-year history.

As Cook has grown over the years, so has our impact on the state of Indiana, said Pete Yonkman, president of Cook Medical and Cook Group, in a Cook-issued news release. But our impact goes well beyond jobs. Our renovation of historic buildings has helped revitalize entire communities, and our partnerships with universities across the state are helping pave the way for the next generation of Indiana leaders and innovators.

Founded in Bloomington in 1963, Cook Medical employs more than 7,000 workers throughout the state. The medical device manufacturer makes 16,000 products that serve 13 hospital lines across 135 countries, according to the IEDC release.

Bright & Williamson Insurance Agency, an insurance agency located in Nashville, Indiana, has served the Brown County community since 1921.

Commercial and residential electrical construction company Cassady Electric is a family-owned business that can trace its roots in Bloomington back more than half a century. The business is a certified Women's Business Enterprise, meaning owner Mae Cassady controls at least 51 percent of the company.

"I felt very honored to be nominated," Cassady said. "I guess I never thought I would leave Kentucky at 19, and 50-some odd years later, I would be doing this."

Nominated by the Bloomington Economic Development Corp., Cassady said she credited some success to Bloomington's welcoming a woman business owner. Cassady said treating her customers the way she wants to be treated has helped keep the business alive.

Indiana Limestone Co., with a headquarters in Bedford, was recognized for its 91 years since several smaller business merged to form the company in 1926.

It recognizes that we have a great legacy, stretching beyond the founding of our firm 91 years ago to the predecessor firms that were quarrying this stone back into the 19th century," Tom Quigley, Indiana Limestone Co. CEO, said in an email. "The work ethic that has been part of this company from the beginning is every bit as important as the world-class stone that has helped create the architectural landscape of America.

The limestone supplier has provided material for the Empire State Building, the National Cathedral and more than half the state capitols in the nation.

"In every major city across the country, there was an Indiana Limestone Co. sales office. Name a major place, and they had a sales office there that helped further the use of Indiana limestone," Chief Operating Officer Duffe Elkins said. "We've been quarrying stone since Lincoln was president, that's what I like to tell people."

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Cook Medical, Indiana Limestone among local business recognized for longevity - The Herald-Times (subscription)

Study: Parenthood can boost your longevity – Detroit Free Press – Detroit Free Press

Ana Veciana-Suarez, Miami Herald (TNS) 11:08 p.m. ET March 18, 2017

Spinning might look about the same as outdoor cycling or riding a stationary bike, but in many ways, it's a far more intense workoutand one of the easiest to overdo. Time

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For the second year in a row, Naples, Fla. and its surrounding area take the top spot as healthiest and happiest in America as part of the Gallup-Healthways 2016 Community Well-Being Rankings. Buzz60

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A new study links bacon and other foods we love to many U.S. deaths. Researchers also found the same link for not eating enough healthy foods. Sean Dowling (@seandowlingtv) has more. Buzz60

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A study out of Sweden says parenting can extend your life.(Photo: David Sacks/Getty Images)

Want to live longer? Have children.

If you don't die early from child-rearing stress, parenthood will boost your longevity chances, according to a new study out of Sweden.

Researchers at the Karolinska Institute used national registry data to track 1.5 million Swedes born between 1911 and 1925 as they lived through their last years.

While the risk of death naturally increased with age for all adults, the team found that those with children had greater longevity.

"Support from adult children to aging parents may be of importance for parental health and longevity," researchers write. "At old age, the stress of parenthood is likely to be lower and instead, parents can benefit from social support from their children. In addition, parents have on average more healthful behaviors than childless individuals."

The study, published in the Journal of Epidemiology and Community Health, also revealed that having children is actually more beneficial as you age, and it is particularly greater for men than women.

Men who were not married but had children were also living longer than those with a spouse. For example, 60-year-old men who had children had about two years more of life than those without, with a life expectancy of 20.2 and 18.4 years respectively.

Bag of toys in a bathtub(Photo: Creatas Images via Getty Images)

For women at 60, those with children had life expectancies of 24.6 years while those without children had 23.1.

The life expectancy difference continued as the study group grew older. By 80, parents had a life expectancy of 7.7 years for men and 9.5 years for women. In comparison, the 80-year-olds without children had a life expectancy of 7 years for men without children and 8.9 years for women without children.

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The sex of the child had no influence on their parent's longevity, according to researchers, but it should be noted that this finding was based only on families with one child.

"Perhaps being the only child is related to a greater responsibility of parents, reducing the difference in the amount of help given by sons and daughters," they study authors write.

Of course parenthood isn't the only thing boosting longevity.

"In terms of all other causes that would affect your death risk in these old ages, having a child is not among the greatest ones," study co-author Karin Modig told The Guardian. "But it is still a 1.5 percent difference [for 90-year-old men] which is still substantial."

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Study: Parenthood can boost your longevity - Detroit Free Press - Detroit Free Press

Deutsche Bank loses longevity risk expert – Financial News (subscription)

Deutsche Bank loses longevity risk expert
Financial News (subscription)
Reid joined Deutsche Bank in 2010 and has worked in its debt capital markets and corporate coverage business. He was previously head of the European longevity business at Credit Suisse and, before that, at the investment consultant Willis Towers Watson.

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Patterns of protein synthesis associated with increased longevity discovered – Science Daily

Aging is a complex process that involves multiple metabolic and regulatory pathways. Previous studies have identified hundreds of genes whose deletion can significantly increase lifespan in model organisms. Yet, how these different aging genes and pathways are interconnected remains poorly understood.

Researchers from Boston University School of Medicine (BUSM) have uncovered new regulatory factors that link gene expression profiles with aging. The study, which appears in the journal Cell Reports, could help identify new therapeutic targets for potential interventions for human diseases associated with old age, such as type 2 diabetes, cancer, neurodegenerative disorders and cardiovascular disease.

Using a technique called ribosome profiling or Ribo-seq, the researchers identified common and unique patterns of protein synthesis associated with increased longevity.

"Hundreds of genes are known to affect aging and one of the major challenges now is to understand how different aging genes and pathways are interconnected. These findings could provide us a better view on what aging is and how we can manipulate some of these factors to improve the quality of life in older age," explained corresponding author Vyacheslav Labunskyy, PhD, assistant professor of dermatology at BUSM.

According to the researchers by expanding this analysis to dozens of additional mutants, they hope to build a comprehensive interaction network linking regulatory factors with aging-associated genes. "Given that many of these genes and pathways are present in higher species including mammals, such studies could help identify new therapeutic targets for potential interventions for human diseases associated with aging. However, more research is needed to study how activity of these regulatory factors and signaling networks changes with age.

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The role of weight in postmenopausal women's longevity … – Science Daily

In a large multiethnic study, being underweight was linked with an increased risk of early death among postmenopausal women. Also, a higher waist circumference -- but not being overweight or slightly obese -- was associated with premature mortality, indicating that abdominal fat is more deadly than carrying excess weight.

Interestingly, Hispanic women in the study had a lower mortality rate at any given body mass index or waist circumference compared with non-Hispanic whites or African-Americans.

"We have used data from the large prospective cohort of the US Women's Health Initiative to add evidence on the relationship of general and central obesity with all-cause mortality in older women, especially in African American and Hispanic American older women, who have not been well represented in previous research on this topic," said Dr. Zhao Chen, lead author of the Journal of the American Geriatrics Society study. "Our study findings have called public health attention to reduce central obesity in older women from different racial/ethnic groups and to reconsider recommendations on the range of healthy body mass index in older women."

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Link between dietary restriction, longevity examined – Mount Desert Islander

BAR HARBOR Scientists at the MDI Biological Laboratory have published research which improves the understanding of the mechanisms by which the lifespan of roundworms can be lengthened by cutting back on calories.

It has been known for decades that drastically restricting certain nutrients without causing malnutrition prolongs health and lifespan in a wide range of species, but the molecular mechanisms underlying this effect have remained a mystery.

In a paper recently published in the journal Aging Cell, MDI Biological Laboratory scientist Aric Rogers shed light on an important genetic pathway underlying this process, raising the possibility that therapies can be developed that prolong the healthy years without having to suffer the consequences of a severely restricted diet.


Its tantalizing to think that we might be able to activate a protective response to enhance our own health without resorting to extreme dietary regimes, Rogers said.

Rogers studies mechanisms important to the positive effects of dietary restriction in an intact organism the tiny roundworm, C. elegans as opposed to cells in a petri dish. This roundworm is an important model in aging research because it shares nearly half of its genes with humans and because of its short lifespan it lives for only two to three weeks which allows scientists to study many generations over a short period of time.

Arics identification of a molecular mechanism governing the life-prolonging effects of dietary restriction is a validation of our unique approach to research in aging and regenerative biology, said Kevin Strange, president of the laboratory. Our use of whole organisms as research models provides greater insight into the many factors controlling physiological processes than the use of cells alone.

The life-prolonging effects of dietary restriction, or calorie restriction, occur in just about every animal tested. They are thought to be an evolutionary adaptation to harsh environmental conditions. In the absence of enough food to eat, evolution has programmed organisms to switch from a growth mode to a survival mode so they can live long enough to reproduce when conditions improve.

The identification of a mechanism underlying the protective effect of dietary restriction could lead to therapies for age-related diseases, including Alzheimers and Parkinsons, that are associated with diminished cellular quality control. Alzheimers, for instance, is associated with the build-up of the toxic protein beta amyloid in the brain, and Parkinsons with a build-up of a toxic protein called alpha synuclein.

The link between aging and weakened cellular housekeeping functions raises the possibility that new drugs to prolong lifespan also could delay the onset of age-related degenerative diseases. Now that Rogers has identified a link, the next step is to investigate cause and effect by manipulating the genetic pathways that inhibit protein formation to see if the bodys ability to clear molecular clutter is improved.

We think therapies to activate these protective pathways could not only prolong lifespan but also delay the onset of age-related diseases, Rogers said. Most older people suffer from multiple chronic diseases. Anti-aging procedures applied to disease models almost always delay disease onset and improve outcomes, which suggests that disease-suppressing benefits may be accessed to extend healthy human lifespan.

The MDI Biological Laboratory, located in Bar Harbor, is an independent, nonprofit biomedical research institution focused on increasing healthy lifespan and increasing our natural ability to repair and regenerate tissues damaged by injury or disease. The institution develops solutions to complex human health problems through research, education and ventures that transform discoveries into cures. Visit mdibl.org.

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