After decades of relative neglect, star-shaped brain cells called astrocytes are getting their due. To gather insight into a critical aspect of brain development, a team of scientists examined the maturation of astrocytes in 3-D structures grown in culture dishes to resemble human brain tissue. The study, which confirms the lab-grown cells develop at the same rate as those found in human brains, was published in Neuron and funded in part by the National Institutes of Healths National Institute of Neurological Disorders and Stroke.
This work addresses a significant gap in human brain research by providing an invaluable technique to investigate the role of astrocytes in both normal development and disease, said NINDS program director Jill Morris, Ph.D.
In 2015, a team directed by Dr. Sergiu Pasca, an assistant professor of psychiatry and behavioral science at Stanford University in California, and Dr. Ben Barres, Ph.D., a Stanford professor of neurobiology, published a method for taking adult skin cells, converting them to induced pluripotent stem cells, and then growing them as 3-D clusters of brain cells called human cortical spheroids (hCSs). These hCSs, which closely resemble miniature versions of a particular brain region, can be grown for many months. The cells in the cluster eventually develop into neurons, astrocytes, and other cells found in the human brain.
One of the challenges of studying the human brain is the difficulty of examining it at different stages of development, Dr. Pasca said. This is a system that tries to simulate brain development step by step.
In the new study, Steven Sloan, a student in Stanfords M.D./Ph.D. program, led a series of experiments comparing astrocytes from hCSs to those found in tissue from the developing and adult human brain. The team grew the hCSs for 20 months, one of the longest-ever studies of lab-grown human brain cells.
The results verified that the lab-grown cells change over time in a similar manner to cells taken directly from brain tissue during very early life, a critical time for brain growth. This process is considered critical for normal brain development and deviations are thought to cause a variety of neurological and mental health disorders, such as schizophrenia and autism. Creating hCSs using cells from patients could allow scientists to uncover the underlying developmental biology at the core of these disorders.
The hCS system makes it possible to replay astrocyte development from any patient, Dr. Barres said. Thats huge. Theres no other way one could ever do that without this method.
The current study showed that hCS-grown astrocytes develop at the same rate as those found in human brains, in terms of their gene activity, their shapes, and their functions. For example, astrocytes taken from hCSs that were less than six months old multiplied rapidly and were highly engaged in eliminating unnecessary connections between neurons, just like astrocytes in babies growing in the womb. But astrocytes grown in hCSs for more than nine months could not reproduce and removed significantly fewer of those connections, mirroring astrocytes in infants 6 to 12 months old. On the other hand, just like astrocytes from developing and adult brains, the early- and late-stage astrocytes from hCSs were equally effective at encouraging new connections to form between neurons.
Astrocytes are not just bystanders in the brain, Dr. Pasca said. Theyre not just there to keep neurons warm; they actually participate actively in neurological function.
Since astrocytes make up a greater proportion of brain cells in humans than in other species, it may reflect a greater need for astrocytes in normal human brain function, with more significant consequences when they dont work correctly, added David Panchision, Ph.D., program director at the National Institute of Mental Health (NIMH), which also helped fund the study.
The researchers caution that hCSs are only a model and lack many features of real brains. Moreover, certain genes that are active in fully mature astrocytes never switched on in the hCS-grown astrocytes, which they could conceivably do if the cells had more time to develop. To address this question, the researchers now hope to identify ways to produce mature brain cells more quickly. hCSs could also be used to scrutinize precisely what causes astrocytes to change over time and to screen drugs that might correct any differences that occur in brain disease.
These are questions that are going to be very exciting to explore, Dr. Barres said.
The study was funded by NINDS, the National Institute of Mental Health, the National Institute of General Medical Sciences, the National Center for Advancing Translational Sciences, the California Institute of Regenerative Medicine, the MQ Fellow Award, and Stanford University.
The NINDS is the nations leading funder of research on the brain and nervous system. The mission of NINDS is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease.
The mission of the NIMH is to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery and cure. For information, visit the NIMH website.
The National Institute of General Medical Sciences supports basic research that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment and prevention. For information, visit the NIGMS website.
The National Center for Advancing Translational Sciences (NCATS) was established to transform the translational process so that new treatments and cures for disease can be delivered to patients faster. For information, visit the NCATS website.
The National Institutes of Health, the nation's medical research agency, encompasses 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For information about NIH and its programs, visit http://www.nih.gov.
View original post here:
Scientists give star treatment to lesser-known cells crucial for brain development - Seacoastonline.com
- Dan Ariely: It’s OK to cheat and steal (sometimes) - April 7th, 2010 [April 7th, 2010]
- Full Sail Behavioral Science Leadership Podcast - August 27th, 2011 [August 27th, 2011]
- Full Sail Behavioral Science Passion - August 27th, 2011 [August 27th, 2011]
- 13H Refutes CCHR: Industry of Death (Behavioral Science) - August 28th, 2011 [August 28th, 2011]
- College of Social and Behavioral Science - August 28th, 2011 [August 28th, 2011]
- GB: Behavioral Science Bill For Propaganda - August 29th, 2011 [August 29th, 2011]
- Criminal Minds - The Behavioral Science Part 2 - August 31st, 2011 [August 31st, 2011]
- Santhula Hospital - A clinical and research center for Nuero-behavioral Science - August 31st, 2011 [August 31st, 2011]
- Behavioral Science Self-Assesment Project - September 2nd, 2011 [September 2nd, 2011]
- Behavioral Science: OPTIMAN - September 3rd, 2011 [September 3rd, 2011]
- Forget the Cinderella effect: stepparents are just as likely to kill their biological children as their stepchildren - September 4th, 2011 [September 4th, 2011]
- The Behavioural Science Blog in 2010 - September 4th, 2011 [September 4th, 2011]
- introduction to behavioral science - September 4th, 2011 [September 4th, 2011]
- CSU's Behavioral Sciences Building - September 5th, 2011 [September 5th, 2011]
- Criminal Minds Season 2 - Backstage - Behavioral Science Real-life Criminal Minds (1 of 2) - September 6th, 2011 [September 6th, 2011]
- Behavioral Science: Goldielocks - September 6th, 2011 [September 6th, 2011]
- Dean Welcome Message - CalSouthern School of Behavioral Sciences - September 7th, 2011 [September 7th, 2011]
- Criminal Minds - The Behavioral Science Part 1 - September 9th, 2011 [September 9th, 2011]
- TEDx Bandung-Roby Muhamad-Socio Behavioural Science - September 14th, 2011 [September 14th, 2011]
- How Behavioral Science Applies to Marketing - Jason Anello - September 14th, 2011 [September 14th, 2011]
- Public Health Behavioral Science - September 15th, 2011 [September 15th, 2011]
- Full Sail Behavioral Science Video - September 15th, 2011 [September 15th, 2011]
- Introduction to Behavioural Science - September 15th, 2011 [September 15th, 2011]
- University of Arizona College of Social and Behavioral Sciences Commencement Speech - September 17th, 2011 [September 17th, 2011]
- Introduction to Behavioral Sciences OSPE - September 17th, 2011 [September 17th, 2011]
- Get to know NAU's College of Social and Behavioral Sciences - September 20th, 2011 [September 20th, 2011]
- 3 Minute Thesis 2010 runner-up - Will Harrison, Faculty of Social - September 24th, 2011 [September 24th, 2011]
- New Behavioral Sciences Building at Colorado State University - September 27th, 2011 [September 27th, 2011]
- Intro to Psych Statistics - September 28th, 2011 [September 28th, 2011]
- Why Do Voles Fall in Love? - September 29th, 2011 [September 29th, 2011]
- Behavioral Science: What problems do you have in your life? - September 30th, 2011 [September 30th, 2011]
- Behavioral Solutions for Climate - October 3rd, 2011 [October 3rd, 2011]
- College of Social and Behavioral Sciences (SBS) 2010 Senior Celebration - October 4th, 2011 [October 4th, 2011]
- Enhance Student Teaching Podcast - Full Sail University Behavioral Science Class - October 4th, 2011 [October 4th, 2011]
- Music and the Brain: Depression and Creativity Symposium - October 4th, 2011 [October 4th, 2011]
- Experiment Test - October 4th, 2011 [October 4th, 2011]
- Helen Palmer and The Enneagram - October 4th, 2011 [October 4th, 2011]
- Rapid Learning: Behavioral Science And Patient Treatment - Behavioral Physiolgy - October 4th, 2011 [October 4th, 2011]
- Meet Nicole in the Colorado State University Behavioral Sciences Building - October 4th, 2011 [October 4th, 2011]
- Life As A Full Sail Student Ep. 5 (Behavioral Science) - October 5th, 2011 [October 5th, 2011]
- Happy holidays from your friends in the College of Business and Behavioral Science - October 5th, 2011 [October 5th, 2011]
- Behavioral Science Jumping Hurdles Full Sail University - October 5th, 2011 [October 5th, 2011]
- Dr. Meera Narasimhan on Mental Illnesses - Part 1 - October 5th, 2011 [October 5th, 2011]
- Science needs you: Test your word power on iPhone / iPad with Science XL free app - October 5th, 2011 [October 5th, 2011]
- Definition of Culture - October 5th, 2011 [October 5th, 2011]
- OSP Presentation: Bou's Clues (University of Santo Tomas, Behavioral Science) - October 6th, 2011 [October 6th, 2011]
- Behavioral Sciences OSPE Part 7: Informational Care - October 6th, 2011 [October 6th, 2011]
- Criminal Minds Season 2: Behavioral Science - October 7th, 2011 [October 7th, 2011]
- Behavioral Science - York College CUNY - October 7th, 2011 [October 7th, 2011]
- Miswakology Behavioral Sciences - October 7th, 2011 [October 7th, 2011]
- Criminal Minds Season 2 - Backstage - Behavioral Science Real-life Criminal Minds (2 of 2) - October 11th, 2011 [October 11th, 2011]
- Behavioral Science (A Lesson In Self Control) - October 12th, 2011 [October 12th, 2011]
- BEHAVIORAL SCIENCE LECTURE 1 - Video - October 13th, 2011 [October 13th, 2011]
- TEDxGoodenoughCollege - Jan-Emmanuel De Neve - The Genetics of Happiness - Video - October 13th, 2011 [October 13th, 2011]
- Using Denial to Cope with Grief and Depression - Winifred Gallagher - Video - October 13th, 2011 [October 13th, 2011]
- How To Survive Full Sail University - Video - October 14th, 2011 [October 14th, 2011]
- Life Positive Expo 2008 Appreciate Inquiry with Dr. Wasundhara Joshi and R Sankarasubramanyan - Video - October 14th, 2011 [October 14th, 2011]
- Dr. Meera Narasimhan on Mental Illnesses - Part 3 - Video - October 14th, 2011 [October 14th, 2011]
- Learning and Memory - Video - October 16th, 2011 [October 16th, 2011]
- Behavioral Science Proposal - Video - October 17th, 2011 [October 17th, 2011]
- 13H Refutes CCHR: IOD (Chapter 7) Psychosurgery (1/2) - Video - October 23rd, 2011 [October 23rd, 2011]
- 13H Refutes CCHR: IOD (Chapter 8) Psychiatric Drugs (1/2) - Video - October 23rd, 2011 [October 23rd, 2011]
- OUTDATED : Psychology and Behavioral Sciences Collection - Video - October 24th, 2011 [October 24th, 2011]
- CSUDH College of Natural and Behavioral Sciences - October 24th, 2011 [October 24th, 2011]
- Behavioral Science - October 24th, 2011 [October 24th, 2011]
- Behavioral science project. ( just one part of it) - Video - October 24th, 2011 [October 24th, 2011]
- Ramp Modeling for Dickies (UST- Behavioral Science Presentation) - Video - October 24th, 2011 [October 24th, 2011]
- Search in Psychology and Behavioral Sciences - PSCY 2301 - Video - October 25th, 2011 [October 25th, 2011]
- Forgiveness: Jesus vs Behavioral Science - Video - October 25th, 2011 [October 25th, 2011]
- PsyD Graduate Discusses her Learning Experience at CalSouthern School of Behavioral Sciences - Video - October 25th, 2011 [October 25th, 2011]
- Behavioral Science Statistics: One Sample and Dependent t-te - Video - October 26th, 2011 [October 26th, 2011]
- Full Sail University Behavioral Science Self-Awareness Exercise - Video - October 26th, 2011 [October 26th, 2011]
- FBI Behavioral Science Unit Interview - Part 2 - Video - October 26th, 2011 [October 26th, 2011]
- Full Sail BS Lab 2 Proposal - Video - October 27th, 2011 [October 27th, 2011]
- Full Sail University-Behavioral Science- Jumping Hurdles Project - Video - October 27th, 2011 [October 27th, 2011]
- Being Human - Behavioral Science Project - Video - October 27th, 2011 [October 27th, 2011]
- Behavioral Sciences OSPE Part 3: Compliance - Video - October 27th, 2011 [October 27th, 2011]
- Behavioral Science Film Fest feat. BSA1D '09 - Video - October 28th, 2011 [October 28th, 2011]
- Dan Pink Plenary Speaker Landsdowne Residency, March 2010 - Video - November 7th, 2011 [November 7th, 2011]
- Psychology and Behavioral Sciences Collection - Video - November 8th, 2011 [November 8th, 2011]