CHARLEROI, Belgium--(BUSINESS WIRE)--
During the inauguration of its new building, the Belgian Biotech Company Delphi Genetics SA announced that the first antibiotic-free DNA vaccine using the Staby technology was efficiently tested in vivo. Together with academic and Biotech key-players, Delphi Genetics is participating to the DNAVAC project funded by the Walloon Region (BioWin project). The aim of the project is to develop and produce antibiotic-free DNA vaccines targeting veterinary diseases. As a model, the consortium developed a DNA vaccine against the Aujezsky virus the causative agent of pseudo-rabies.
This virus was selected as it causes systematically an acute and lethal disease in susceptible species, thereby providing an excellent model to test the efficacy of a vaccine candidate. The results of the challenge performed by Dr Anca Reschner are very clear: all vaccinated animals using the Staby vectors were resistant to the lethal Aujeszky virus. said Prof. Alain Vanderplasschen from the University of Lige (Immunology-Vaccinology).
Cdric Szpirer PhD, Delphi Genetics co-Founder and CEO, explained: This is the first real DNA vaccine produced using the Staby technology. Several DNA vectors have been made in the past to generate production of antibodies, but this is the first time that in vivo tests were performed in order to evaluate efficiency against a disease. All production steps of the vaccine were performed efficiently avoiding completely the use of antibiotic-resistance genes as recommended by regulatory authorities (FDA, USDA, EMA). These results validate the use of Staby outside the field of protein production.
Indeed, a few weeks ago, on October, 8 Delphi Genetics announced a broad licensing agreement with a subsidiary of Merck & Co., Inc., known as MSD outside the United States and Canada, for the use of the StabyExpress technology to produce proteins in the areas of human and animal health. The same technology was licensed previously to Sanofi-Pasteur (2009) and GSK (2010) for production of proteins used in human vaccines.
As announced on January, 30, 2012, the DNAVAC project involves a consortium including Eurogentec SA, another Belgian Biotech company (part of Kaneka) in charge of large scale DNA production and purification, and two universities: the Catholic University of Louvain in charge of pharmaceutical and toxicity studies associated with the project and the University of Lige in charge of vaccinology and veterinary aspects.
About Delphi Genetics SA
Founded at the end of 2001, Delphi Genetics SA develops technologies for genetic engineering and protein expression using unique expertise in the domain of plasmid stabilisation systems. Since 2004, Delphi Genetics has been marketing innovative kits and services for researchers. Some of these kits contain the Staby technology that has since been licensed for industrial applications (see above). Indeed, the Staby technology can be applied to any industrial DNA or protein production process that involves bacterial fermentation. Delphi Genetics is involved in several research projects including adaptation of the technology to yeast and mammalian cells.
Original post:
The Staby® Technology from Delphi Genetics Efficiently Applied To DNA-Vaccine
- Molecular Visualizations of DNA - August 27th, 2011 [August 27th, 2011]
- DNA Structure - August 27th, 2011 [August 27th, 2011]
- Time Is Money Presents: Dna vs. T-rex - August 27th, 2011 [August 27th, 2011]
- DNA Replication Process - August 27th, 2011 [August 27th, 2011]
- darwin deez - dna (official video) - August 27th, 2011 [August 27th, 2011]
- The Secret of Life -- Discovery of DNA Structure - August 27th, 2011 [August 27th, 2011]
- DNA - Blonde Red Head (from Downtown 81) - August 27th, 2011 [August 27th, 2011]
- How Big is Your Genome? Strange DNA - August 27th, 2011 [August 27th, 2011]
- DNA live - August 27th, 2011 [August 27th, 2011]
- Amanda Knox's father says DNA evidence 'critical' - September 11th, 2011 [September 11th, 2011]
- Judge: No more DNA testing in Amanda Knox appeal - September 11th, 2011 [September 11th, 2011]
- NASA | DNA Building Blocks Can Be Made in Space - September 11th, 2011 [September 11th, 2011]
- Starchild Skull- The SHOCKING DNA Results Are In....WATCH THIS! *HD* - September 11th, 2011 [September 11th, 2011]
- Svante Pääbo: DNA clues to our inner neanderthal - September 11th, 2011 [September 11th, 2011]
- CIA may have tried 'to trick DNA from Bin Laden' - September 11th, 2011 [September 11th, 2011]
- SMACK/ URL Presents DNA vs X-Factor - September 11th, 2011 [September 11th, 2011]
- Court denies re-test of DNA in Amanda Knox trial - September 11th, 2011 [September 11th, 2011]
- Chapter 10: Tenacious DNA - September 23rd, 2011 [September 23rd, 2011]
- dna - September 23rd, 2011 [September 23rd, 2011]
- Saul Williams - DNA - September 23rd, 2011 [September 23rd, 2011]
- DNA--Not Moving - September 23rd, 2011 [September 23rd, 2011]
- DNA Extraction Home Experiment - September 23rd, 2011 [September 23rd, 2011]
- How to extract DNA from strawberries - September 23rd, 2011 [September 23rd, 2011]
- frequency 528 Hz (DNA repair frequency ?) : NO MUSIC single tone - September 23rd, 2011 [September 23rd, 2011]
- darwin deez - dna [director's cut] - September 23rd, 2011 [September 23rd, 2011]
- DNA Replication Song - September 23rd, 2011 [September 23rd, 2011]
- BioRap (DNA Replication and Protein Synthesis with a Beat) - September 23rd, 2011 [September 23rd, 2011]
- DNA Transcription and Protein Assembly - September 23rd, 2011 [September 23rd, 2011]
- 888 Gateway DNA Meditation - September 23rd, 2011 [September 23rd, 2011]
- From DNA to Protein - September 23rd, 2011 [September 23rd, 2011]
- Blame it on the DNA - September 24th, 2011 [September 24th, 2011]
- DNA Replication - September 24th, 2011 [September 24th, 2011]
- Recombinant DNA ©2004 Demonstratives, Inc. - September 24th, 2011 [September 24th, 2011]
- A Flock of Seagulls - DNA - September 24th, 2011 [September 24th, 2011]
- DNA - Detached (from Downtown 81) - September 24th, 2011 [September 24th, 2011]
- Aliens, UFOs, DNA - September 25th, 2011 [September 25th, 2011]
- DNA Speaks On Recent Battles And X-Factor - September 25th, 2011 [September 25th, 2011]
- The DNA of the World's Most Innovative Companies - September 25th, 2011 [September 25th, 2011]
- Anunnaki Human DNA 1 - September 25th, 2011 [September 25th, 2011]
- Host DNA Dicing - Green Phat Bet - 11bill+ Total - - September 25th, 2011 [September 25th, 2011]
- Judge Alex - DNA Test - September 25th, 2011 [September 25th, 2011]
- Prosecution downplays DNA in Knox appeal - September 26th, 2011 [September 26th, 2011]
- NASA officially announces alien DNA found in meteorites. - September 26th, 2011 [September 26th, 2011]
- Antimatter Found, Artificial DNA ,Social Unrest - September 26th, 2011 [September 26th, 2011]
- Chrono Khalid - DNA activation 2.0 - September 26th, 2011 [September 26th, 2011]
- 'Baby' Alien found by farmer in Mexico - DNA tests and scans baffles scientists - September 26th, 2011 [September 26th, 2011]
- DNA : The Secret Of Life (PBS) - September 26th, 2011 [September 26th, 2011]
- DNA - Size - September 27th, 2011 [September 27th, 2011]
- Starchild Skull 2010 DNA Result - September 28th, 2011 [September 28th, 2011]
- Cowboy BeBop- Ask DNA - September 28th, 2011 [September 28th, 2011]
- Symphony of Science -- DNA and Life - September 30th, 2011 [September 30th, 2011]
- Molecular Biology Visualization of DNA - October 2nd, 2011 [October 2nd, 2011]
- Same Dna Livin Life Ep 8 - October 4th, 2011 [October 4th, 2011]
- Danny Brown - DNA - October 4th, 2011 [October 4th, 2011]
- Rockmond Dunbar Traces His DNA To Nigeria - October 5th, 2011 [October 5th, 2011]
- TEDxFortGreeneSalon - Melvin Gibbs - The DNA Project - October 5th, 2011 [October 5th, 2011]
- Building a tiny "DNA brain" (Part I: design) - October 5th, 2011 [October 5th, 2011]
- DNA "Post-Summer Madness 2011" Interview Part 1 [EME] - October 5th, 2011 [October 5th, 2011]
- Proof that Evolution is True/Real/Fact: Mutations, DNA, Natural Selection - October 9th, 2011 [October 9th, 2011]
- DA John Bradley once excluded DNA testing - October 9th, 2011 [October 9th, 2011]
- Benbassat Says Apple's `DNA' Will Continue After Jobs - October 10th, 2011 [October 10th, 2011]
- BRO BOBBY HEMMITT; DNA TRANSFORMATION part 1 - October 10th, 2011 [October 10th, 2011]
- DNA - 2 Ounces And A Dream (Instrumental) - October 10th, 2011 [October 10th, 2011]
- The Truth About Italian DNA - October 10th, 2011 [October 10th, 2011]
- DNA - Ludovico Einaudi - October 13th, 2011 [October 13th, 2011]
- DNA - FAIR FIGHT (THE SNITCH) PROD BY : BLESSED BY THE BEATS - Video - October 13th, 2011 [October 13th, 2011]
- DNA REPAIR - Video - October 13th, 2011 [October 13th, 2011]
- DNA MUTATION - Video - October 14th, 2011 [October 14th, 2011]
- Spiritual DNA - Video - October 14th, 2011 [October 14th, 2011]
- DNA Structure - Video - October 14th, 2011 [October 14th, 2011]
- DNA - Video - October 14th, 2011 [October 14th, 2011]
- DNA Replication - Video - October 14th, 2011 [October 14th, 2011]
- THE DNA SONG - Video - October 14th, 2011 [October 14th, 2011]
- That Spells DNA by Jonathan Coulton - Video - October 15th, 2011 [October 15th, 2011]
- DNA Activation Power - 2012 Ascension - Video - October 15th, 2011 [October 15th, 2011]
- Journey Inside The Cell - Video - October 15th, 2011 [October 15th, 2011]
- DNA - ROMAN NUMERALS (MUSIC VIDEO) - Video - October 15th, 2011 [October 15th, 2011]
- DNA - Blonde Red Head - Video - October 16th, 2011 [October 16th, 2011]
- [HD] The Kills - DNA (Live in Paris @ Bataclan, April 6th, 2011) - Video - October 17th, 2011 [October 17th, 2011]
- Blackfield - DNA - Video - October 22nd, 2011 [October 22nd, 2011]