In 2008, the Joint Research Centre, Institute for Health and Consumer Protection of the European Commission funded the project Engineered Nanoparticles: Review of Health and Environmental Safety (ENRHES). Last month, the ENRHES project released its final report. The overall aim of the ENRHES project was to perform a comprehensive and critical scientific review of the health and environmental safety of four classes of nanomaterials: fullerenes, carbon nanotubes, metals and metal oxides. The review considers sources, pathways of exposure, the health and environmental outcomes of concern, illustrating the state-of-the-art and identifying knowledge gaps in the field, in order to coalesce the evidence which has emerged to date and inform regulators of the potential risks of engineered nanoparticles in these specific classes.