LUNGS-ON-DEMAND. In the U.S. alone, more than 1,400 people are waiting for a lung transplant — there simply aren’t enough donor lungs available to meet the need. Soon, though, patients might have a new source for brand new lungs: the lab.
On Wednesday, researchers from University of Texas Medical Branch published a new paper in the journal Science Translational Medicine. In it, they detail their latest milestone along the path to creating lab-grown lungs for humans: they can now successfully transplant these bioengineered lungs into pigs.
THIS LITTLE PIGGY GETS A NEW LUNG. To grow the lungs, the researchers first created four lung scaffolds. To do this, they removed all of the cells and blood from pig lungs using a mix of sugar and detergent. This left them with just the proteins of each lung — essentially, its skeleton.
Next, they placed each scaffold in a tank containing a special mix of nutrients. They then added cells from recipient pigs’ own lungs to each of the scaffolds and let the lungs grow for 30 days. Finally, they transplanted the four lab-grown lungs into the four recipient pigs.
Within two weeks, the transplanted lungs had already begun to establish the robust networks of blood vessels they need to survive. During two months of post-transplant observation, the researchers found no signs that the animals’ immune systems had rejected the new lungs. But they next want to study the long-term viability of the organs.
MOVING TO HUMANS. Bioengineered organs are something of a holy grail in transplantation research. Because they are grown from the recipient’s own cells, the body is less likely to reject the organ, and we could grow them in the lab as needed — no more organ shortages.
If all goes as hoped with the pig experiments, the researchers believe they could be just five to 10 years away from being able to create lab-grown lungs to transplant into people in compassionate use circumstances (people with life-threatening conditions and essentially no other treatment options).
Eventually, bioengineered lungs could replace donor ones altogether. And that could make the transplant waiting list a thing of the past.
READ MORE: Production and Transplantation of Bioengineered Lung Into a Large-Animal Model [Science Translational Medicine]
More on bioengineering: Researchers Can Now Bioengineer Lungs With the Original Blood Vessels Intact
The post We Can Now Successfully Transplant Lab-Grown Lungs in Pigs appeared first on Futurism.
Read more:
We Can Now Successfully Transplant Lab-Grown Lungs in Pigs
- Futurist Serata featuring artist Luca Buvoli at Brown (Nov. 20) - November 7th, 2009 [November 7th, 2009]
- FUTUR1SM00GGI - November 8th, 2009 [November 8th, 2009]
- ‘Futurism on Film’ Series this month in NYC - November 8th, 2009 [November 8th, 2009]
- Schedule of Futurist Events in NYC (PERFORMA 09: Nov 1-22) - November 8th, 2009 [November 8th, 2009]
- ‘Futurismo/Futurizm: The Futurist Avant-Garde in Italy and Russia’ (Nov. 13 + 14) - November 8th, 2009 [November 8th, 2009]
- ‘Beyond Futurism: F.T. Marinetti, Writer’ conference at Columbia (Nov. 12+13) - November 8th, 2009 [November 8th, 2009]
- Futurism and Cars at the Museo Nicolis - November 8th, 2009 [November 8th, 2009]
- MoMA Film Series Marks Centenary of Futurism with Films - November 8th, 2009 [November 8th, 2009]
- ‘Bergson+Futurism. Speed in thought’ - Madrid (Nov. 5) - November 8th, 2009 [November 8th, 2009]
- ‘The Future in Five Senses: Echoes of Italian Futurism in New York Architecture and Design’ Nov. 16th NYC - November 8th, 2009 [November 8th, 2009]
- New World-Wide Climate Treaty in 2010 More Likely - November 8th, 2009 [November 8th, 2009]
- Tar Sands CCS Myth Shattered - November 8th, 2009 [November 8th, 2009]
- Smart Grid and Smart Meters Get Big Grants - November 8th, 2009 [November 8th, 2009]
- Pollution Makes Methane Even More Dangerous - November 8th, 2009 [November 8th, 2009]
- Climate Change Bill Hearing Video - November 8th, 2009 [November 8th, 2009]
- New Satellite to Monitor Water and Plant Growth - November 8th, 2009 [November 8th, 2009]
- Spiritual Battle Awaits the Deniers and Skeptics - November 8th, 2009 [November 8th, 2009]
- Effects of Climate Change are Observed World-Wide - November 8th, 2009 [November 8th, 2009]
- Get Yer Global Warming Science Here - November 8th, 2009 [November 8th, 2009]
- TckTckTck Wake up Call — Delay Kills - November 8th, 2009 [November 8th, 2009]
- Canada’s Awful Gold Rush - November 8th, 2009 [November 8th, 2009]
- Climate Change Talks Spark Global Backlash by Businesses - November 8th, 2009 [November 8th, 2009]
- World May Need Extra Year for Climate Treaty - November 8th, 2009 [November 8th, 2009]
- Senator Boxer Moves Climate Bill Despite Republican Obstructionism - November 8th, 2009 [November 8th, 2009]
- Lights out for incandescent lights? - November 8th, 2009 [November 8th, 2009]
- Sutures from Bacteria - November 8th, 2009 [November 8th, 2009]
- Remote-Controlled Pigeons - November 8th, 2009 [November 8th, 2009]
- Apple Announces iPhone Release Date - November 8th, 2009 [November 8th, 2009]
- UK Government Envisions a Grim Future - November 8th, 2009 [November 8th, 2009]
- Top Ten Emerging Technologies for the Environment - November 8th, 2009 [November 8th, 2009]
- DIY Mobile Networks - November 8th, 2009 [November 8th, 2009]
- Stem-Cell Treatment Cures Type 1 Diabetes - November 8th, 2009 [November 8th, 2009]
- Is Tesla Getting the Electric Car Right? - November 8th, 2009 [November 8th, 2009]
- The Future of TV News - November 8th, 2009 [November 8th, 2009]
- Bruce Sterling on Earth-Friendly Pervasive Computing - November 8th, 2009 [November 8th, 2009]
- First Step Toward Organ Regeneration in Humans - November 8th, 2009 [November 8th, 2009]
- IBM's "Five in Five" - November 8th, 2009 [November 8th, 2009]
- Outsourced Journalism - November 8th, 2009 [November 8th, 2009]
- Is True Global Democracy the Next Great Political Movement? - November 8th, 2009 [November 8th, 2009]
- The Risks of Autonomous Robots - November 8th, 2009 [November 8th, 2009]
- Microsoft Introduces "Tabletop" PC - November 8th, 2009 [November 8th, 2009]
- Britain Piloting First Biofueled Train - November 8th, 2009 [November 8th, 2009]
- Self-Healing Plastic - November 8th, 2009 [November 8th, 2009]
- Bird Population Falls Over Past 40 Years - November 8th, 2009 [November 8th, 2009]
- The iPhone Revolution? - November 8th, 2009 [November 8th, 2009]
- The End of "Cheap Food"? - November 8th, 2009 [November 8th, 2009]
- How to Stop -- Or Live With -- Global Warming - November 8th, 2009 [November 8th, 2009]
- MIT Demonstrates "Wireless Electricity" - November 8th, 2009 [November 8th, 2009]
- Unintended Consequences of Biofuels - November 8th, 2009 [November 8th, 2009]
- Time to Focus on the Big Picture in Copenhagen - December 12th, 2009 [December 12th, 2009]
- Protests in Copenhagen - December 12th, 2009 [December 12th, 2009]
- Mario Guido Dal Monte exhibit - December 13th, 2009 [December 13th, 2009]
- Futurism News Bulletin, xvi - December 13th, 2009 [December 13th, 2009]
- Viva il Futurismo! (video trailer) - December 13th, 2009 [December 13th, 2009]
- 3 exhibits in Gorizia! - December 13th, 2009 [December 13th, 2009]
- Forthcoming: ‘Antidiets of the Avant-garde’ by Cecilia Novero - December 13th, 2009 [December 13th, 2009]
- Pubblicità e propaganda. Ceramica e grafica futuriste at the Wolfsoniana - December 13th, 2009 [December 13th, 2009]
- Balla’s home scheduled to open in 2010 - December 13th, 2009 [December 13th, 2009]
- Futurismo a Savona - December 13th, 2009 [December 13th, 2009]
- ‘Zang Sud Sud’, Cosenza - December 13th, 2009 [December 13th, 2009]
- Conference in Rome (Dec. 10) - December 13th, 2009 [December 13th, 2009]
- Climate Hackergate: A Well-Orchestrated Campaign of Harassment - December 13th, 2009 [December 13th, 2009]
- The Sad Story of Cap and Trade - December 13th, 2009 [December 13th, 2009]
- How to Waste Trillions on Capturing Carbon - December 13th, 2009 [December 13th, 2009]
- Smack the Email Hack Attack - December 13th, 2009 [December 13th, 2009]
- EPA About to Declare CO2 a Public Danger - December 13th, 2009 [December 13th, 2009]
- Copenhagen Summit Starts with Virtually There Media - December 13th, 2009 [December 13th, 2009]
- Climate Scientist Gets Blunt on Trading Scheme - December 13th, 2009 [December 13th, 2009]
- One Climate Change Editorial in 56 Newspapers, 45 Countries - December 13th, 2009 [December 13th, 2009]
- This Decade Will be Hottest Ever on Record - December 13th, 2009 [December 13th, 2009]
- Divide and Conquer - December 13th, 2009 [December 13th, 2009]
- Leave the Coal in the Hole! - December 13th, 2009 [December 13th, 2009]
- COP15: Two Agreements Coming - December 13th, 2009 [December 13th, 2009]
- Climate and Copenhagen News December 10 - December 13th, 2009 [December 13th, 2009]
- Sea Level Already Rising on Atlantic Coast - December 13th, 2009 [December 13th, 2009]
- ‘Umbria Veloce’ in Perugia - December 14th, 2009 [December 14th, 2009]
- An Instable CO2-Filled Ocean - December 14th, 2009 [December 14th, 2009]
- ‘Futurismi a Ravenna’ opens Dec. 19 - December 15th, 2009 [December 15th, 2009]
- ‘Futurism and the Technological Imagination’ – 30% discount until Jan. 15 - December 15th, 2009 [December 15th, 2009]
- Protecting Our Lungs at Copenhagen - December 15th, 2009 [December 15th, 2009]