Home – Weatherall Institute of Molecular Medicine

The mission of the MRC Weatherall Institute of Molecular Medicine (WIMM) is to undertake internationally competitive research into the processes underlying normal cell and molecular biology and to determine the mechanisms by which these processes are perturbed in inherited and acquired human diseases. It is also our mission to translate this research to improve human health Continue reading



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Home - Weatherall Institute of Molecular Medicine

Genetic flaws in bowel cancer may trigger immune response at site of tumours

Published on March 23, 2015 at 8:16 AM Scientists have found that genetic changes in bowel tumours are linked to the way the body’s immune system responds to the cancer, according to research published today (Monday) in the journal Oncoimmunology*. Continue reading



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Genetic flaws in bowel cancer may trigger immune response at site of tumours

Researchers in Berlin tweak the immune system to target cells bearing tumor antigens

Researchers at the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch and Charit – Universittsmedizin Berlin, Campus Berlin-Buch, have succeeded in generating cells of the immune system to specifically target and destroy cancer cells. The research findings of Matthias Obenaus, Professor Thomas Blankenstein (MDC and Charit), Dr. Continue reading



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Researchers in Berlin tweak the immune system to target cells bearing tumor antigens

With genetic engineering, scientists use decoy molecule to trick HIV

An effective vaccine for HIV has eluded researchers for several decades, due to the pathogen’s infamous shape-shifting abilities. Even though researchers have identified certain broadly neutralizing antibodies that can conquer multiple strains of the human immunodeficiency virus, many strains of rapidly mutating HIV remain resistant to the these super antibodies. In recent years however,researches have proposed a new method of battling the virus that involves gene therapy. Continue reading



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With genetic engineering, scientists use decoy molecule to trick HIV

A new twist on HIV vaccines shows results in monkeys, study says

An effective vaccine for HIV has eluded researchers for several decades, due to the pathogen’s infamous shape-shifting abilities. Even though researchers have identified certain broadly neutralizing antibodies that can conquer multiple strains of the human immunodeficiency virus, many strains of rapidly mutating HIV remain resistant to the these super antibodies. In recent years however,researches have proposed a new method of battling the virus that involves gene therapy Continue reading



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A new twist on HIV vaccines shows results in monkeys, study says

Space flight can age immune system prematurely

Spending long duration on space flights may accelerate ageing of the immune system in astronauts, finds a research. “This study shows that a model of spaceflight conditions could not only be used to test the efficacy of molecules to improve immune responses following a spaceflight in astronauts but also in the elderly and bed-ridden populations on Earth,” said Jean-Pol Frippiat, researcher from Lorraine University in Vandoeuvre-les-Nancy, France. This model could also help understanding the aging of the immune system called immunosenescence, he said. Continue reading



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Space flight can age immune system prematurely

Ottawa patients sought for testing of stem cell therapy …

Retired teacher Margo Murchison does not qualify for the testing of stem cell treatments for MS but she says the possible breakthrough gives her hope. At a time when there is growing concern about patients travelling overseas for unproven treatments, Canadian doctors are beginning clinical trials of stem cell therapy they say offers real hope for people with multiple sclerosis Continue reading



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Ottawa patients sought for testing of stem cell therapy ...

Early Study Says Stem Cells May Reverse Multiple Sclerosis Disability

By Amy Norton HealthDay Reporter TUESDAY, Jan. 20, 2015 (HealthDay News) — A therapy that uses patients’ own primitive blood cells may be able to reverse some of the effects of multiple sclerosis, a preliminary study suggests. The findings, published Tuesday in the Journal of the American Medical Association, had experts cautiously optimistic Continue reading



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Early Study Says Stem Cells May Reverse Multiple Sclerosis Disability

New Cellular Pathway Triggering Allergic Asthma Response Identified

Contact Information Available for logged-in reporters only Newswise Researchers at the University of California, San Diego School of Medicine, with collaborators in Korea and Scotland, have identified a novel signaling pathway critical to the immune response of cells associated with the initiation of allergic asthma. The discovery, they say, could point the way to new therapies that suppress the inflammatory allergic response, offering potential relief to millions of Americans with the chronic lung condition and potentially other allergic diseases Continue reading



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New Cellular Pathway Triggering Allergic Asthma Response Identified

UMMS to develop a model for predicting gene expression in dendritic cells

Insight into regulation of the genes that allow the immune system to recognize pathogens will help scientists rationally design new vaccines and prevent autoimmunity WORCESTER, MA – UMass Medical School scientists Jeremy Luban, MD, and Manuel Garber, PhD, will be principal investigators on a 3-year, $6.1 million grant to develop a model for predicting whether a given gene will be turned on or off under specific conditions. Continue reading



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UMMS to develop a model for predicting gene expression in dendritic cells