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St. Amant Primary teachers implement ideas with Ascension Fund grants - Weekly Citizen
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Ascension Parish food distribution event rescheduled for April 23 - Weekly Citizen
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St. Amant, Ascension Catholic reach softball state tournament - Weekly Citizen
After an incredibly powerful short movie and a ton of different promotional materials, The Knave is finally coming as playable in Genshin Impact. But before Arlecchino can display her true potential, youll need to farm for certain ascension materials first.
As a 5-star Pyro Polearm character, Arlecchino is far from being the first in this specific role. However, she brings some unique gameplay with her scythe-like attacks that sacrifice a portion of her HP. According to the official Genshin Impact Progression Calculator, this is what you need to level up her fully.
Arlecchino shares a lot of materials with her fellow Pyro Fatui and son Lyney. They even share the Rainbow Rose specialty for their ascension. The Insignia drops can all be obtained from various Fatui enemies across the map, so use the Adventurers Handbook to get their locations if you havent enough of these with you. However, her assigned World Boss is the Statue of Marble and Brass world boss, a new addition to the 4.6 version.
Related: Genshin Impacts New Metroidvania Web Event is Scratching My Hollow Knight Silksong Itch
More Fatui-related items here, so double down on farming those. Arlecchino uses the Order books from the Rhyming Rhythm domain in Fontaine to level up her talents, as well as the new items from her own Weekly Boss, The Knave. Sometimes you are your worst enemy, I guess. As of 4.1, players no longer need to advance through Story Quests to farm for bosses, so you can challenge her boss version from the get-go.
The hardest part is, without a doubt, getting enough Roses and Talent items, as these will take you most of your time/resin to accomplish. Not to mention the artifact grind for her build which is always a struggle, but very worth it in the end.
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All Arlecchino Ascension Materials in Genshin Impact - The Escapist
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Ascension Parish man pleads guilty to manslaughter in 2016 fatal shooting of fiance - Weekly Citizen
The six-story Women & Childrens Tower under construction on the hospitals West 86th Street campus will feature both private neonatal intensive care unit rooms and pediatric intensive care unit rooms. (IBJ photo/Eric Learned)
In the past five years, the nations largest Catholic health system, Ascension, has unloaded more than a dozen hospitals across the country, from New York to Alabama, as it restructures amid a growing tide of red ink.
In Indiana alone, it shut a critical-access hospital in Bedford, closed 11 immediate-care walk-in centers in central Indiana and shut down or repurposed five small neighborhood hospitals.
And theres no sign the sell-off is over.
Ascension continues selling spree, said a headline last month in Beckers Hospital Review, a trade news site, which added that the St. Louis-based system has more deals in the pipeline.
Ascension hastens exit out of Michigan, said a headline in Crains Detroit this month, after the health care system sold three hospitals in the northern part of the state to a large health system affiliated with the University of Michigan and set up a joint venture with another large system in the Detroit area.
Ascension, trying to dig itself out from a $3billion operating loss in fiscal year 2023, has not limited its sell-off to hospitals. It has also sold its interest in laboratory operations and a health insurance group.
So does Ascension plan to close or sell more Indiana assets?
In an unusual move for a national hospital system amid a major restructuring, Ascension disclosed part of its plans. It is not considering offloading or closing any more Indiana operations, an Ascension corporate spokeswoman told IBJ in an email.
The changes to our footprint in other parts of our national ministry are designed to ensure sustainable and favorable options for those communities, the email said. There are no plans to make any such changes to our Indiana ministry.
Several health care consultants said they would be shocked if Ascension sold a large number of properties in Indiana or exited the state altogether, as it has done elsewhere.
I wouldnt just be surprised. I would be totally aghast, said Ed Abel, retired director of health care practice at Indianapolis-based Blue & Co., an accounting and consulting firm. I would just say its never going to happen.
Thats because Indiana is one of the systems most profitable operations, delivering $192million in net income for the system for the fiscal year ending June 30, 2022, the most recent Indiana figures available. The same year, the system as a whole lost $879million from operations.
Translation: Indiana is a moneymaker for Ascension, helping it to fund a huge system that otherwise would be posting much larger losses.
So any further cost-cutting in Indiana would be relatively minor, some experts say.
In general, large health systems are constantly tweaking their portfolios, said David Blish, director of health care consulting for Katz Sapper & Miller, an Indianapolis-based accounting and consulting firm. I doubt Indiana Ascension will contract at a significant scale.
Ascension pointed to its flagship campus on West 86th Street, where construction continues on $325million worth of improvements, including a new brain and spine center, a new womens and childrens tower, and a new parking garage.
The company said the investments will help the companys operations here, known as Ascension St. Vincent Indiana, a premier destination for care in the Midwest.
Separately, Ascension St. Vincent this week issued invitations for a public celebration marking the 50th anniversary of the companys West 86th Street hospital. It said the event will take place 2-4 p.m. April 28 on top of the parking garage at the corner of Harcourt Drive and Katie Knox Drive.
The 50th anniversary of our 86th Street location gives us the opportunity to honor all of those who contributed to making the hospital what it is today as well as look forward to the future of health care, the invitation said.
The event will mark the 1974 move, when staff of St. Vincent and the U.S. Army Reserves transferred 102 patients from the hospitals Fall Creek campus (now part of Ivy Tech Community College) to a new campus on the northwest side of Indianapolis, which was then largely fields and forest.
Twenty-five years later, in 1999, Ascension bought St. Vincent for an undisclosed amount.
That marked the end of more than a century of independent ownership, since four nuns from the Daughters of Charity religious order arrived in Indianapolis in 1881 at the invitation of Catholic Bishop Francis Chatard and set up St. Vincent Infirmary in a house near Vermont and East streets.
Within a few years, the infirmary grew to 50 beds and changed its named to St. Vincent Hospital. It relocated twice before the move to West 86th Street. After decades of expansion, that campus now fills the better part of 20 square blocks between West 86th and West 79th streets.
Ascension said the six-story Women & Childrens Tower going up on the south side of the campus is designed to address the high level of maternal and infant mortality in Indianapolis. It will feature 109 private neonatal intensive care unit rooms along with an expanded pediatric intensive care unit. The tower is scheduled to be completed this year.
The four-story Brain and Spine Hospital is rising at the front of the campus and will include operating rooms, an intensive care unit, an intensive care step-down unit, and a residency training program. Ascension said it expects construction to be completed early next year.
The new projects, announced in 2021, represent one of the largest capital investments in decades for Ascension Indiana. It also gave the strong suggestion that the corporate parent was committed to the Indianapolis flagship, a major anchor on the busy West 86th Street commercial corridor.
So why is Ascension building here while unloading hospitals elsewhere and exiting some states altogether?
In many cases, the answer seems to be that Ascension is leaving where it cannot take advantage of a wide system of community hospitals in coordination with a top-tier hospital to handle complex cases.
In modern health care, hospital systems increasingly want a network of hospitals that can act as feeders for the major hospital in a large metropolitan area. And if they are a small player in a market that is dominated by a huge competitor, they have less chance to fill beds, negotiate favorable insurance plans and make money.
In Minnesota, the world-famous Mayo Clinic dominates the market with net patient revenue of $3.32billion in 2022far ahead of second place University of Minnesota Medical Center, which pulled in $1.68billion.
Who is ever going to beat the Mayo Clinic there? Abel said. Yes, theres a lot of competition up there. But theres a lot that have dropped out and said, Were never going to be as good as those guys.
Central Indiana has no single dominant player. Instead, there are four or five large players and a few dozen small players, mostly in the suburbs. And each system has a different claim to fame.
In the nine-county metropolitan area, Ascension St. Vincent has the most staffed beds, with 1,995, ahead of Indiana University Health (1,514), Community Health Network (1,124), Franciscan Health Network (563) and Eskenazi Health (333), according to IBJ research. (Those figures are from 2022, the most recent year available.)
Yet in the same year, Indiana University Health pulled in far more revenue across its statewide system, $8.1billion, than Ascension St. Vincent ($3.7billion) and Community Health ($3.1billion).
Statewide, Ascension owns 19 hospitals from Anderson to Brazil, including facilities in Carmel, Fishers, Indianapolis, Anderson and Kokomo.
In addition to being a large player, Ascension St. Vincent is performing well financially in central Indiana and has no reason to start offloading assets, Abel said.
Indiana is what I would call an aircraft carrier for Ascension, he said. They have a huge presence here, and theyre proud of it.
And Ascensions corporate leadership clearly has a soft spot for Indiana. The companys CEO, Joseph Impicciche, was raised in Crawfordsville and earned his bachelors at Wabash College. He went on to earn a law degree and a master of health administration degree from Indiana University. He practiced for more than a decade at Indianapolis law firm Hall Render Killian Heath & Lyman, which specializes in health care law.
Ascension declined to make Impicciche or any other senior leader available for an interview with IBJ.
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The total prize pool for the first 2024 WoW Eve Ascension tournament will be $10,000. The event will also feature five bounties worth $200 each. As for the second WoW Eve Ascension tournament, details for it will be revealed on a later date, according to Team Liquid.
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Team Liquid Eve Ascension enters World of Warcraft! | esports.gg - Esports.gg
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Although the specificity of CRISPR-based gene-editing is highly accurate and versatile, the efficiency of installing those edits has been low. In this paper, the Adamson lab describes a more efficient prime editor. Illustration by Caitlin Sedwick for Princeton University.
Credit: Caitlin Sedwick for Princeton University
By Caitlin Sedwick for the Princeton University Department of Molecular Biology
Through years of engineering gene-editing systems, researchers have developed a suite of tools that enable the modification of genomes in living cells, akin to genome surgery. These tools, including ones based on a natural system known as CRISPR/Cas9, offer enormous potential for addressing unmet clinical needs, underscored by the recent FDA approval of the first CRISPR/Cas9-based therapy. A relatively new approach called prime editing enables gene-editing with exceptional accuracy and high versatility, but has a critical tradeoff: variable and often low efficiency of edit installation. In other words, while prime edits can be made with high precision and few unwanted byproducts, the approach also often fails to make those edits at reasonable frequencies. In a paper that appeared in print in the journal Nature on April 18th, 2024, Princeton scientists Jun Yan and Britt Adamson, along with several colleagues, describe a more efficient prime editor.
Prime editing systems minimally consist of two components: a modified version of the protein element of CRISPR/Cas9 and a ribonucleic acid (RNA) molecule called a pegRNA. These components work together in several coordinated steps: First, the pegRNA binds the protein and guides the resulting complex to a desired location in the genome. There, the protein nicks the DNA and, using a template sequence encoded on the pegRNA, reverse transcribes an edit into the genome nearby. In this way, prime editors write exact sequences into targeted DNA.
"Prime editing is such an incredibly powerful genome editing tool because it gives us more control over exactly how genomic sequences are changed, Adamson said.
At the outset of their study, Adamson and Yan, a graduate student in Adamsons research group and the Department of Molecular Biology, reasoned that unknown cellular processes may aid or hinder prime editing. To identify such processes, Yan laid out a conceptually simple plan: First, he would engineer a cell line that would emit green fluorescence when certain prime edits were installed. Then, he would systematically block expression of proteins normally expressed within those cells and measure editing-induced fluorescence to determine which of those proteins impact prime editing. By executing this plan, the team identified 36 cellular determinants of prime editing, only one of whichthe small RNA-binding protein Lapromoted editing.
Although promoting prime editing is obviously not a normal function of the La protein, our experiments showed that it can strongly facilitate the process, Yan said.
Within cells, La is known to bind specific sequences often found at the ends of nascent small RNA molecules and it protects those RNAs from degradation. The Princeton team recognized right away that the pegRNAs deployed in Yans first experiments likely contained those exact sequences, called polyuridine tracts, as they are a typical but often overlooked byproduct of pegRNA expression in cells. Subsequent experiments suggested that such pegRNAs inadvertently harness Las end-binding activity for protection and to promote prime editing.
Motivated by their results, the team asked if fusing the part of La that binds polyuridine tracts to a standard prime editing protein could boost prime editing efficiencies. They were thrilled to find that the resulting protein, which they call PE7, substantially enhanced intended prime editing efficiencies across conditions and, when using some prime editing systems, left the frequencies of unwanted byproducts very low. Their results quickly drew the attention of colleagues interested in using prime editing in primary human cells, including Daniel Bauer at Boston Childrens Hospital and Harvard Medical School and Alexander Marson at the University of California, San Francisco. Together with scientists from these labs, the team of researchers went on to demonstrate that PE7 can also enhance prime editing efficiencies in therapeutically relevant cell types, offering expanded promise for future clinical applications.
"This work is a beautiful example of how deeply probing the inner workings of cells can lead to unexpected insights that may yield near-term biomedical impact, Bauer noted.
Citation: Jun Yan, Paul Oyler-Castrillo, Purnima Ravisankar, Carl C. Ward, Sbastien Levesque, Yangwode Jing, Danny Simpson, Anqi Zhao, Hui Li, Weihao Yan, Laine Goudy, Ralf Schmidt, Sabrina C. Solley, Luke A. Gilbert, Michelle M. Chan, Daniel E. Bauer, Alexander Marson, Lance R. Parsons & Britt Adamson.Improving prime editing with an endogenous small RNA-binding protein.Nature. 2024. DOI: https://doi.org/10.1038/s41586-024-07259-6
Funding for this work was provided by the National Institutes of Health (NIH) (R35GM138167, RM1HG009490, T32HG003284, DP2CA239597, UM1HG012660 [Princeton QCB training grant; NHGRI],and [T32GM007388 Princeton MOL training grant; NIGMS]); the Searle Scholars Program; thePrinceton Catalysis Initiative; CHDI Foundation; Princeton University; the Parker Institute for Cancer Immunotherapy (PICI); the Lloyd J. Old STAR award from the Cancer Research Institute (CRI); the Simons Foundation; the CRISPR Cures for Cancer Initiative; the Arc Institute; CRUK/NIH (OT2CA278665 and CGCATF-2021/100006); Pew-Stewart Scholars for Cancer Research award; the Doris Duke Foundation; the St Jude Childrens Research Hospital Collaborative Research Consortium; NHLBI (R01HL150669); the Fred Hutch Cooperative Center of Excellence in Hematology (U54 DK106829); the China Scholarship Council (CSC), based on the April 2015 Memorandum of Understanding between the CSC and Princeton University; the NCI (K00CA245718); and the Princeton University Flow Cytometry Resource Facility (NCI-CCSG P30CA072720-5921).
Experimental study
Improving prime editing with an endogenous small RNA-binding protein
3-Apr-2024
B.A. is an advisory board member with options for Arbor Biotechnologies and Tessera Therapeutics. B.A. holds equity in Celsius Therapeutics. L.A.G has filed patents on CRISPR tools and CRISPR functional genomics and is a co-founder of Chroma Medicine. A.M. is a co-founder of Arsenal Biosciences, Site Tx, Spotlight Therapeutics, and Survey Genomics, serves on the boards of directors at Site Tx, Spotlight Therapeutics and Survey Genomics, is a member of the scientific advisory boards of Arsenal Biosciences, Site Tx, Spotlight Therapeutics, Survey Genomics, NewLimit, Amgen, Tenaya, and Lightcast, owns stock in Arsenal Biosciences, Site Tx, Spotlight Therapeutics, NewLimit, Survey Genomics, PACT Pharma, Tenaya, and Lightcast, and has received fees from Arsenal Biosciences, Spotlight Therapeutics, Site Tx NewLimit, Survey Genomics, Gilead, 23andMe, PACT Pharma, Juno Therapeutics, Tenaya, Lightcast, Trizell, Vertex, Merck, Amgen, Genentech, AlphaSights, Rupert Case Management, Bernstein, GLG, ClearView Healthcare Partners, and ALDA. A.M. is an investor in and informal advisor to Offline Ventures and a client of EPIQ. The Marson Laboratory has received research support from Juno Therapeutics, Epinomics, Sanofi, GlaxoSmithKline, Gilead, and Anthem. C.C.W. and R.S. are co-founders of Site Tx. J.Y. and B.A. have filed a patent application on aspects of this work through Princeton University, and B.A. has previously filed other patents on CRISPR-based technologies. The remaining authors declare no competing interests.
Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.
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A small factor makes a big impact on genome editing - EurekAlert
Fellow at the Genetic Engineering and Society (GES) Center of the North Carolina State University Joseph Opoku Gakpo is urging Ghanas National Biosafety Authority (NBA) to step up its communications efforts on genetically modified organisms (GMOs).
Speaking at a webinar organised by the Africa Genetic Biocontrol Consortium on "gaps, challenges, and innovations in science communication, he said recent media reports in which some stakeholders condemned the approval of 14 genetically engineered products in the country could have been avoided through proactive communication.
A report by the United States Department for Agriculture published last month disclosed the authority has approved 14 new GMOs including eight corn events and six soybean events.
The report drew backlash from some groups including the Peasant Farmers Association, Ghana Agricultural Workers Union, Ghana Journalists for Environment, Science, Health and Agriculture (GJESHA), and the Centre for Climate Change and Food Security (CCCFS), among others.
The Peasant Farmers Association warned its members will not accept any GMO seeds under the governments flagship Planting for Food and Jobs programme.
The authority subsequently clarified in a statement that the approval is for the GMOs to be imported for use as feed, food, and for processing, and not for local cultivation.
Mr. Gakpo questioned why the authority did not find it necessary to inform Ghanaians about the approval early in the year, and waited until a foreign entity told the story first.
The approval was in February. The USDA report was published on 20th March and has been making rounds on various social media platforms.
"It wasnt until April 14 before the NBA issued a statement clarifying what it had done. How will Ghanaians feel about hearing of this approval first from a foreign partner? he quizzed.
The NBA should have been the first to put a statement, at least on its website, explaining what exactly it had done and not have created a situation where other institutions had to tell their story for them, Mr Gakpo said.
So, there wasnt proactive communication. It was simply reactive communication. And even the reactive communication happened almost a month later. The authority needs to step up its communications efforts, he added.
Mr. Gakpo whose research at the GES Center focuses on how communication influences the deployment of agricultural biotechnologies noted the National Biosafety Act 2011 which governs the operations of the NBA urges it to prioritise proactive communication.
Section 4 (d) of Act 831 says one of the functions of the authority is to promote public awareness, participation and education concerning the activities of the authority under this Act he said.
Section 41(2) also says the Authority shall publish notices of final decisions concerning applications made under this Act in the Gazette and the electronic and print media, he explained.
Mr. Gakpo said the law passed by parliament recognises the important role of the media in helping disseminate information on genetic technologies and the authority must do more in that regard.
I am not saying the Biosafety Authority is shirking its responsibility to communicate. Because I have seen officials from the authorities do media interviews and other such communication activities.
"But I am only saying they need to do more. And they should particularly be proactive rather than always fighting back, he added.
Cecilia Lubanga who is a communication specialist at the Office of the Senate in Kenya also told the webinar the field of communicating science is changing quickly and actors in the industry need to be abreast with the latest developments.
Science communication is a rapidly evolving field, driven by advancements in technology, changes in societal attitudes, and the effective dissemination of complex scientific information to diverse audiences, she said.
DISCLAIMER: The Views, Comments, Opinions, Contributions and Statements made by Readers and Contributors on this platform do not necessarily represent the views or policy of Multimedia Group Limited.
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National Biosafety Authority urged to step up its communication efforts on GMOs - Myjoyonline
Selbyville, Delaware, April 22, 2024 (GLOBE NEWSWIRE) -- DNA Synthesis Market size is expected to reach a remuneration of USD 20.5 billion by 2032. Rising advancements in biotechnology and genetic engineering across various research, diagnostic, and therapeutic applications will augment the industry growth.
Request for a sample of this research report @ https://www.gminsights.com/request-sample/detail/6000
With the rise of precision medicine and personalized healthcare, there is a growing need for custom-designed DNA sequences tailored to specific research objectives or patient requirements. For instance, in March 2024, global genomics solutions provider Integrated DNA Technologies (IDT) expanded its gene synthesis offerings by introducing a new custom vector onboarding tool. The advancing fields of synthetic biology and gene editing techniques, such as CRISPR-Cas9 have further propelled the demand for DNA synthesis, as researchers seek to engineer novel organisms and develop innovative therapies for various diseases.
Collaborations between academic institutions, biotechnology companies, and pharmaceutical firms are also facilitating the development of cutting-edge technologies and streamlined workflows in DNA synthesis. These partnerships foster innovation and knowledge exchange, driving advancements in the methodologies while expanding the repertoire of available synthetic DNA products. Furthermore, the increasing affordability and accessibility of DNA synthesis services, coupled with improvements in synthesis throughput and scalability are democratizing access to synthesized DNA for researchers worldwide.
Rising usage for diagnostics
DNA synthesis market share from the therapeutic application segment is slated to gain momentum through 2024-2032. This is driven by the increasing adoption of molecular diagnostics for disease detection and personalized treatment approaches. Custom-designed DNA sequences help in the development of molecular diagnostic tests, enabling precise detection of genetic mutations and biomarkers associated with various diseases. The advent of targeted therapies and gene editing technologies has also fueled the demand for synthesized DNA in therapeutic applications.
CRO segment to gain traction
The DNA synthesis market from the contract research organization (CRO) segment is expected to expand exponentially up to 2032. This is driven by specialized expertise and infrastructure for DNA synthesis services for catering to the diverse needs of pharmaceutical, biotechnology, and academic research institutions. These organizations possess state-of-the-art facilities equipped with high-throughput synthesis platforms and experienced scientific teams capable of delivering custom-designed DNA sequences with precision and efficiency. CROs also provide end-to-end solutions, including gene synthesis, cloning, and sequence verification, allowing clients to focus on their core research objectives while entrusting the synthesis process to specialized professionals.
Asia Pacific to emerge as a prominent industry
Asia Pacific DNA synthesis market is estimated to record significant valuation by 2032, attributed to the increasing investment in genomics research and biotechnology initiatives by governments and private enterprises across countries like China, Japan, and India. The rising prevalence of genetic disorders and infectious diseases in the region has spurred the demand for customized DNA sequences for diagnostic and therapeutic applications. Advancements in healthcare infrastructure and the growing adoption of precision medicine will further stimulate the regional industry growth.
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DNA Synthesis Industry Players
Some of the prominent DNA synthesis market players include Thermo Fisher Scientific, Inc., ELISA experts, Twist Bioscience, BOSTER antibody, Bioneer Corporation, ProteoGenix, Eton Bioscience, BIOMATIK, LGC Biosearch Technologies, ProMab Biotechnologies, IBA GmbH, Eurogentec, Eurofins Scientific, Quintara Biosciences OriGene Technologies, Inc., Integrated DNA Technologies, Inc.and GenScript Biotech Corporation.
These firms are focusing on partnership ventures and innovations to proliferate their product portfolio and customer base. To cite an instance, in August 2023, Genscript Biotech formed a strategic collaboration agreement with T-MAXIMUM Biotech to develop CAR-T cell therapy.
Partial Table of Contents (ToC) of the report:
Chapter 2Executive Summary
2.1 Global DNA synthesis market 360 synopsis, 2018 2032 2.1.1 Business trends 2.1.2 Regional trends 2.1.3 Service trends 2.1.4 Method trends 2.1.5 Application trends 2.1.6 End-use trends Chapter 3DNA Synthesis Industry Insights 3.1 Industry ecosystem analysis 3.2 Industry impact forces 3.2.1 Growth drivers 3.2.1.1Growing prevalence of diseases globally 3.2.1.2Rapid technology advancements in the field of synthetic biology 3.2.1.3Rising investments towards research and development(R&D) activities 3.2.2 Industry pitfalls & challenges 3.2.2.1Stringent government regulations and guidelines 3.2.2.2High cost, potential biosafety,biosecurity and ethical issues 3.3 Growth potential analysis 3.3.1 By service 3.3.2 By method 3.3.3 By application 3.3.4 By end use 3.4 COVID- 19 impact analysis 3.5 Regulatory landscape 3.5.1 U.S. 3.5.2 Europe 3.6 Porter's analysis 3.7 PESTEL analysis
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About Global Market Insights
Global Market Insights Inc., headquartered in Delaware, U.S., is a global market research and consulting service provider, offering syndicated and custom research reports along with growth consulting services. Our business intelligence and industry research reports offer clients with penetrative insights and actionable market data specially designed and presented to aid strategic decision making. These exhaustive reports are designed via a proprietary research methodology and are available for key industries such as chemicals, advanced materials, technology, renewable energy, and biotechnology.
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DNA Synthesis Market to hit USD 20.5 Bn by 2032, says Global Market Insights Inc. - GlobeNewswire
Researchers from the Netherlands have reported an extremely long Covid-19 infection in a man who died last year and warn of the emergence of more dangerous variants of the coronavirus.
The elderly man, who was immunocompromised due to previous illnesses, was admitted to a hospital in Amsterdam in February 2022 with a Covid-19 infection, according to a statement.
He was continuously positive for the coronavirus until his death in October 2023 for a total of 613 days.
Other cases of very long infections in people whose immune systems were unable to adequately fight the virus have previously been reported.
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The researchers led by Magda Vergouwe from the University of Amsterdam plan to present the results at a congress of the European Society for Clinical Microbiology and Infectious Diseases in Barcelona on April 27-30.
The case is also interesting for researchers because the coronavirus can change particularly strongly in such long-term infected people. This harbours the risk of variants of the virus emerging that can more easily overcome the immune systems of healthy people.
The researchers in the Netherlands repeatedly took samples from the man to analyse the genetic material of the coronavirus. They found a total of more than 50 mutations compared to the Omicron variant BA.1 that was circulating at the time, including those that would allow the virus to evade the immune defence.
Just 21 days after the man had received a certain anti-coronavirus drug, the virus also developed signs of resistance to it.
German with comically large number of Covid jabs 217 had no side effects
The man eventually died from a flare-up of one of his previous illnesses. As far as is known, he had not infected anyone with his mutated version of the coronavirus, also known under its scientific name Sars-CoV-2.
This case highlights the risk of new immune-evasive Sars-CoV-2 variants emerging in immunocompromised patients, the researchers are quoted as saying in the press release.
The extensive development of the virus in a single patient could lead to the emergence of unique variants, they warn.
It is important to closely monitor the evolution of the coronavirus in immunocompromised individuals. There is a risk that variants could emerge and spread in society that are less susceptible to the immune systems of healthy people, they added
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A new reportby Dutch scientists revealed a very peculiar case: On Feb. 2022, a 72-year-old man with a compromised immune system was admitted to Amsterdam University Medical Center with aCOVID-19infection. The virus in his body proceeded to evolve over the course of 613 days, leading to a highly mutated variant that ultimately killed him.
According to the study, the man, whose identity was not disclosed, suffered from a blood disorder. Despite receiving multiple doses of the SARS-CoV-2 vaccine, his compromised immune system made him unable to generate a detectable antibody response, allowing the virus to continue to evolve into a "novel immune-evasive variant" that had mutated over 50 times. The man died from his underlying blood disorder after fighting COVID for nearly two years, the scientists from the University of Amsterdams Centre for Experimental and Molecular Medicine stated.
This case underscores the risk of persistent SARS-CoV-2 infections in immunocompromised individuals as unique SARS-CoV-2 viral variants may emerge due to extensive intra-host evolution," the study authors stated ina press release. "We emphasize the importance of continuing genomic surveillance of SARS-CoV-2 evolution in immunocompromised individuals with persistent infections given the potential public health threat of possibly introducing viral escape variants into the community.
While the study notes there have been cases in which people have tested positive for COVID-19 for hundreds of days, this case is the longest reported by far. Furthermore, researchers say the rare variant found in this patient hasn't been reported in anyone else, but emphasize the need for more study to protect the public from potential new variants.
The researchers say they plan to further present this study at the European Society of Clinical Microbiology and Infectious Diseases Global Congress in Barcelona, Spain, startingthis weekend.
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Man dies after 613-day COVID-19 infection that underwent 50 mutations - Scripps News
BEIJING (AP) The hunt for the origins of COVID-19 has gone dark in China, the victim of political infighting after a series of stalled and thwarted attempts to find the source of the virus that killed millions and paralyzed the world for months.
The Chinese government froze meaningful domestic and international efforts to trace the virus from the first weeks of the outbreak, despite statements supporting open scientific inquiry, an Associated Press investigation found. That pattern continues to this day, with labs closed, collaborations shattered, foreign scientists forced out and Chinese researchers barred from leaving the country.
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Dutch medical scientists are warning about the risk of viruses mutating over long periods in infected immunocompromised people.
Forthcoming research from the group relates to a previously reported case of a 72-year-old Dutch man who was infected with the SARS-CoV-2 virus for a record 613 days before dieing from a blood disorder.
The research, which is not yet published or peer-reviewed, will this week be presented at a global congress of the European Society of Clinical Microbiology and Infectious Diseases.
They tracked the evolution of the virus within the mans system, while he was administered the antivirals sotrovimab, sarilumab and dexamethasone.
Samples taken between February 2022 and September 2023 noted more than 50 mutations in the viruss genetic sequence. Evidence of immune escape was also observed in the form of changes multiple changes to the virus spike protein.
During the period of infection, the virus evolved resistance to sotrovimab.
In their presentation, the 6 researchers will argue that immunocompromised patients need close monitoring, not only for their own health outcomes but also for signs of viral change that could spread beyond the patient.
They report that in this case the highly mutated, drug-resistant variant was not passed to anyone else.
This case underscores the risk of persistent SARS-CoV-2 infection in immunocompromised individuals as unique SARS-CoV-2 viral variants may emerge due to extensive intra-host evolution, the researchers write.
Though they note this is an extreme case, they report also monitoring other prolonged infections ranging from a month to 2 years in length.
Prolonged infections in immunocompromised patients are much more common compared to the general community, they say However, from the viewpoint of the general public, prolonged infections remain rare as the immunocompromised population is only a very small percentage of the total population.
Continue reading here:
COVID virus mutated in Dutch man, raising importance of proper immunocompromised care - Cosmos
While theres a strong determination worldwide to return to a new normal in a post-COVID world, the pandemic is nearly impossible to forget. A large amount of data also provides insight we may not want to move past just yethow we handled it.
UNM Political Science Associate Professor and Chair Jami Nelson-Nuez is evaluating COVID policies in a research paper titled, Non-pharmaceutical interventions to combat COVID-19 in the Americas described through daily sub-national data, published
Jami Nelson-Nuez
recently in the journal, Scientific Data, a Nature publication. Throughout the COVID-19 pandemic, she and an international team of researchers investigated the impact of Latin American governments' actions and plans.
Like in the U.S., politics at national, state and local levels influenced decisions on COVID-19 mitigation around the world impacting cases, deaths, hospitalizations, jobs and education. Nelson-Nuez specifically looked at the cause and effect of policies and politics in Bolivia through months of data.
Bolivia is a really interesting case because they have a system that's mainly decentralized creating a lot of variation across different regions. Our main focus was looking at the effects of policies and how they evolved, Nelson-Nuez said. We were extremely productive on the project and our work shed light on the political intersection of the pandemic in Bolivia and how that spoke to what was happening in several other countries.
This tied into what was going on in the United States. It was a deeply political time in our country.These political patterns were reflected across several countries, making for an interesting comparative study. UNM Political Science Associate Professor Jami Nelson-Nuez
The pandemic occurred at a time of upheaval in national politics in Bolivia. After an already tumultuous fall 2019 election, Bolivias transitional government lacked legitimacy and the country was deeply divided.
There was a conflict that had been bubbling for a while. The country was in a moment of crisis of contested leadership. It was interesting to follow how the dynamics of the pandemic in Bolivia were shaped by these political complexities throughout the country, Nelson-Nuez said.
When the elections were postponed a second time, tens of thousands of Bolivians across the country rushed to the streets and protested for months. Part of those protests in some places included creating blockades so that medical equipment couldn't get through.
Bolivia has always been an outlier when it comes to protest. Its people have always been highly mobilized and able to overcome those collective action problems to mount significant protests, Nelson-Nuez said. There's a history in Bolivia of people marching for days to the central government and then occupying the streets in the capital.
With that unrest,non-pharmaceutical interventions(NPIs) were few and far between. A large governmental response given the challenge of already weak state capacity in health services made it difficult to make and enforce coherent policies.
The central government was trying to figure out how to steer the ship for the whole country, while regional and local actors were contesting these decisions, Nelson-Nuez said. The politics and the dynamics of multi-level governance can render local communities very vulnerable to these types of events.
Even with the NPIs and guidance issued over time, it was too little too late. The hospital system fully collapsed in the summer of 2020.
Additionally, given the state of leadership, although some NPIs were issued, there needed to be more public trust to abide by government policies and enable governments to make and enforce policies.Her colleagues found similar results in other Latin American countries.
Underlying disparities in health are political. Underneath health realities are important political factors, and if we ignore those, we really don't understand how and why pandemics are occurring or why health disparities are emerging in the way that they are, Nelson-Nuez said.
Nelson-Nuez says this research is one of many ways public health and politics are intertwined.
Sometimes people don't understand political science. As a discipline, we study power, which means we study resources and the distribution of those resources, Nelson-Nuez said. Health is a resource, and access to services is a resource. We can see political factors across the world that shape the ability of diseases to spread and how deadline global health emergencies can be.
Read this article:
UNM research analyzes government intervention and COVID-19 pandemic - UNM Newsroom
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General Information About At-Home OTC COVID-19 Diagnostic Tests - FDA.gov
BEIJING (AP) The hunt for the origins of COVID-19 has gone dark in China, the victim of political infighting after a series of stalled and thwarted attempts to find the source of the virus that killed millions and paralyzed the world for months.
The Chinese government froze meaningful domestic and international efforts to trace the virus from the first weeks of the outbreak, despite statements supporting open scientific inquiry, an Associated Press investigation found. That pattern continues to this day, with labs closed, collaborations shattered, foreign scientists forced out and Chinese researchers barred from leaving the country.
The investigation drew on thousands of pages of undisclosed emails and documents and dozens of interviews that showed the freeze began far earlier than previously known and involved political and scientific infighting in China as much as international finger-pointing.
As early as Jan. 6, 2020, health officials in Beijing closed the lab of a Chinese scientist who sequenced the virus and barred researchers from working with him.
Scientists warn the willful blindness over coronavirus origins leaves the world vulnerable to another outbreak, potentially undermining pandemic treaty talks coordinated by the World Health Organization set to culminate in May.
At the heart of the question is whether the virus jumped from an animal or came from a laboratory accident. A U.S. intelligence analysis says there is insufficient evidence to prove either theory, but the debate has further tainted relations between the U.S. and China.
Unlike in the U.S., there is virtually no public debate in China about whether the virus came from nature or from a lab leak. In fact, there is little public discussion at all about the source of the disease, first detected in the central city of Wuhan.
Crucial initial efforts were hampered by bureaucrats in Wuhan trying to avoid blame who misled the central government; the central government, which muzzled Chinese scientists and subjected visiting WHO officials to stage-managed tours; and the U.N. health agency itself, which may have compromised early opportunities to gather critical information in hopes that by placating China, scientists could gain more access, according to internal materials obtained by AP.
In a faxed statement, China's Foreign Ministry defended Chinas handling of research into the origins, saying the country is open and transparent, shared data and research, and made the greatest contribution to global origins research. The National Health Commission, China's top medical authority, said the country invested huge manpower, material and financial resources and has not stopped looking for the origins of the coronavirus.
It could have played out differently, as shown by the outbreak of SARS, a genetic relative of COVID-19, nearly 20 years ago. China initially hid infections then, but WHO complained swiftly and publicly. Ultimately, Beijing fired officials and made reforms. The U.N. agency soon found SARS likely jumped to humans from civet cats in southern China and international scientists later collaborated with their Chinese counterparts to pin down bats as SARS natural reservoir.
But different leaders of both China and WHO, Chinas quest for control of its researchers, and global tensions have all led to silence when it comes to searching for COVID-19s origins. Governments in Asia are pressuring scientists not to look for the virus for fear it could be traced inside their borders.
Even without those complications, experts say identifying how outbreaks begin is incredibly challenging and that its rare to know with certainty how some viruses begin spreading.
Its disturbing how quickly the search for the origins of (COVID-19) escalated into politics, said Mark Woolhouse, a University of Edinburgh outbreak expert. Now this question may never be definitively answered.
Secrecy clouds the beginning of the outbreak. Even the date when Chinese authorities first started searching for the origins is unclear.
The first publicly known search for the virus took place on Dec. 31, 2019, when Chinese Center for Disease Control scientists visited the Wuhan market where many early COVID-19 cases surfaced.
However, WHO officials heard of an earlier inspection of the market on Dec. 25, 2019, according to a recording of a confidential WHO meeting provided to AP by an attendee. Such a probe has never been mentioned publicly by either Chinese authorities or WHO.
In the recording, WHOs top animal virus expert, Peter Ben Embarek, mentioned the earlier date, describing it as an interesting detail. He told colleagues that officials were looking at what was on sale in the market, whether all the vendors have licenses (and) if there was any illegal (wildlife) trade happening in the market.
A colleague asked Ben Embarek, who is no longer with WHO, if that seemed unusual. He responded that it was not routine, and that the Chinese must have had some reason to investigate the market. Well try to figure out what happened and why they did that.
Ben Embarek declined to comment. Another WHO staffer at the Geneva meeting in late January 2020 confirmed Ben Embareks comments.
The Associated Press could not confirm the search independently. It remains a mystery if it took place, what inspectors discovered, or whether they sampled live animals that might point to how COVID-19 emerged.
A Dec. 25, 2019, inspection would have come when Wuhan authorities were aware of the mysterious disease. The day before, a local doctor sent a sample from an ill market vendor to get sequenced that turned out to contain COVID-19. Chatter about the unknown pneumonia was spreading in Wuhans medical circles, according to one doctor and a relative of another who declined to be identified, fearing repercussions.
A scientist in China when the outbreak occurred said they heard of a Dec. 25 inspection from collaborating virologists in the country. They declined to be named out of fear of retribution.
WHO said in an email that it was not aware of the Dec. 25 investigation. It is not included in the U.N. health agencys official COVID-19 timeline.
When health officials from Beijing arrived in Wuhan on Dec. 31, they decided to disinfect the market before collecting samples, destroying critical information about the virus. Gao Fu, head of the China CDC, mentioned it to an American collaborator.
His complaint when I met him was that all the animals were gone, said Columbia University epidemiologist Ian Lipkin.
Robert Garry, who studies viruses at Tulane University, said a Dec. 25 probe would be hugely significant, given what is known about the virus and its spread.
Being able to swab it directly from the animal itself would be pretty convincing and nobody would be arguing about the origins of COVID-19, he said.
But perhaps local officials simply feared for their jobs, with memories of firings after the 2003 SARS outbreak still vivid, said Ray Yip, the founding head of the U.S. Centers for Disease Control and Prevention outpost in China.
They were trying to save their skin, hide the evidence, Yip said.
The Wuhan government did not respond to a faxed request for comment.
Another early victim was Zhang Yongzhen, the first scientist to publish a sequence of the virus. A day after he wrote a memo urging health authorities to action, Chinas top health official ordered Zhangs lab closed.
They used their official power against me and our colleagues, Zhang wrote in an email provided to AP by Edward Holmes, an Australian virologist.
On Jan. 20, 2020, a WHO delegation arrived in Wuhan for a two-day mission. China did not approve a visit to the market, but they stopped by a China CDC lab to examine infection prevention and controlprocedures, according to an internal WHO travel report. WHOs then-China representative, Dr. Gauden Galea, told colleagues in a private meeting that inquiries about COVID-19s origins went unanswered.
There are a few cadres who have performed poorly, President Xi Jinping said in unusually harsh comments in February. Some dare not take responsibility, wait timidly for orders from above, and dont move without being pushed.
The government opened investigations into top health officials, according to two former and current China CDC staff and three others familiar with the matter. Health officials were encouraged to report colleagues who mishandled the outbreak to Communist Party disciplinary bodies, according to two of the people.
Some people both inside and outside China speculated about a laboratory leak. Those suspicious included right-wing American politicians, but also researchers close to WHO.
The focus turned to the Wuhan Institute of Virology, a high-level lab that experimented with some of the worlds most dangerous viruses.
In early February 2020, some of the Wests leading scientists, headed by Dr. Jeremy Farrar, then at Britains Wellcome Trust, and Dr. Anthony Fauci, then director of the U.S. National Institutes of Health, banded together to assess the origins of the virus in calls, a Slack channel and emails.
They drafted a paper suggesting a natural evolution, but even among themselves, they could not agree on the likeliest scenario. Some were alarmed by features they thought might indicate tinkering.
There have (been) suggestions that the virus escaped from the Wuhan lab, Holmes, the Australian virologist, who believed the virus originated in nature, wrote in a Feb. 7, 2020, email. I do a lot of work in China, and I can (assure) you that a lot of people there believe they are being lied to.
American scientists close to researchers at the Wuhan Institute of Virology warned counterparts there to prepare.
James DeLuc, head of a Texas lab, emailed his Wuhan colleague on Feb. 9, 2020, saying hed already been approached by U.S. officials. Clearly addressing this will be essential, with any kind of documentation you might have, he wrote.
The Chinese government was conducting its own secret investigation into the Wuhan Institute. Gao, the head of the China CDC, and another Chinese health expert revealed its existence in interviews months and years later. Both said the investigation found no evidence of wrongdoing, which Holmes, the Australian virologist, also heard from another contact in China. But Gao said even he hadn't seen further details, and some experts suspect they may never be released.
WHO started negotiations with China for a second visit with the virus origins in mind, but it was Chinas Foreign Ministry that decided the terms.
Scientists were sidelined and politicians took control. China refused a visa for Ben Embarek, then WHOs top animal virus expert. The itinerary dropped nearly all items linked to an origins search, according to draft agendas for the trip obtained by the AP. And Gao, the China CDC head who is also a respected scientist tasked with investigating the origins, was left off the schedule.
Instead, Liang Wannian, a politician in the Communist Party hierarchy, took charge of the international delegation. Liang is an epidemiologist close to top Chinese officials and China's Foreign Ministry who is widely seen as pushing the party line, not science-backed policies, according to nine people familiar with the situation who declined to be identified to speak on a sensitive subject.
Most of the WHO delegation was not allowed to go to Wuhan, which was under lockdown. The few who did learned little. They again had no access to the Wuhan Institute of Virology or the wildlife market and obtained only scant details about China CDC efforts to trace the coronavirus there.
On the train, Liang lobbied the visiting WHO scientists to praise Chinas health response in their public report. Dr. Bruce Aylward, a senior adviser to WHO Director-General Tedros Adhanom Ghebreyesus, saw it as the best way to meet Chinas need for a strong assessment of its response.
The new section was so flattering that colleagues emailed Aylward to suggest he dial it back a bit.
It is remarkable how much knowledge about a new virus has been gained in such a short time, read the final report, which was reviewed by Chinas top health official before it went to Tedros.
As criticism of China grew, the Chinese government deflected blame. Instead of firing health officials, they declared their virus response a success and closed investigations into the officials with few job losses.
There were no real reforms, because doing reforms means admitting fault, said a public health expert in contact with Chinese health officials who asked not to be identified because of the sensitivity of the matter.
In late February 2020, the internationally respected doctor Zhong Nanshan appeared at a news conference and said that the epidemic first appeared in China, but it did not necessarily originate in China.
Chinese officials told WHO that blood tests on lab workers at the Wuhan Institute of Virology were negative, suggesting they hadnt been previously infected with bat coronaviruses. But when WHO pressed for an independent audit, Chinese officials balked and demanded WHO investigate the U.S. and other countries as well.
By the time WHO led a third visit to Wuhan in January 2021, a year into the pandemic, the atmosphere was toxic.
Liang, the Chinese health official in charge of the first two WHO visits, continued to promote the questionable theory that the virus was shipped into China on frozen food. He suppressed information suggesting it could have come from animals at the Wuhan market, organizing market workers to tell WHO experts no live wildlife was sold and cutting recent photos of wildlife at the market from the final report. There was heavy political scrutiny, with numerous Chinese officials who werent scientists or health officers present at meetings.
Despite a lack of direct access, the WHO team concluded that a lab leak was extremely unlikely. So it came as an infuriating surprise to Chinese officials when, months later, WHO chief Tedros said all origins hypotheses, including the lab leak theory, remained on the table.
China told WHO any future missions to find COVID-19 origins should be elsewhere, according to a letter obtained by AP. Since then, global cooperation on the issue has ground to a halt; an independent group convened by WHO to investigate the origins of COVID-19 in 2021 has been stymied by the lack of cooperation from China and other issues.
Chinese scientists are still under heavy pressure, according to 10 researchers and healthofficials. Researchers who published papers on the coronavirus ran into trouble with Chinese authorities. Others were barred from travel abroad for conferences and WHO meetings. Gao, the China CDC director, was investigated after U.S. President Joe Biden ordered a review of COVID-19 data, and again after giving interviews on the virus origins.
New evidence is treated with suspicion. In March 2023, scientists announced that genetic material collected from the market showed raccoon dog DNA mixed with COVID-19 in early 2020, data that WHO said should have been publicly shared years before. The findings were posted, then removed by Chinese researchers with little explanation.
The head of the China CDC Institute of Viral Disease was forced to retire over the release of the market data, according to a former China CDC official who declined to be named to speak on a sensitive topic.
It has to do with the origins, so theyre still worried, the former official said. If you try and get to the bottom of it, what if it turns out to be from China?
Other scientists note that any animal from which the virus may have originally jumped has long since disappeared.
There was a chance for China to cooperate with WHO and do some animal sampling studies that might have answered the question, said Tulane Universitys Garry. The trail to find the source has now gone cold.
Cheng reported from Geneva.
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Toxic: How the search for the origins of COVID-19 turned politically poisonous - El Paso Inc.
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Takeaways from AP report on how the search for the coronavirus origins turned toxic - Idaho Press