You know what they say the modern version of Pascal's Wager is? Sucking up to as many Transhumanists as possible, just in case one of them turns into God. Julie from Crystal Nights by Greg Egan
Transhumanism (or H+), an intellectual movement, is greatly influenced by science fiction and presents an idealistic point of view of what technology could do for humanity in the future, not what it can do; it's all hypothetical. Transhumanism explores the benefits and repercussions of what technology could do for humanity; however, it assumes the technological boundaries are nonexistent.
How plausible is transhumanism? In the 1930s, many sensible people were sure human beings would never get to the Moon and that was just one of many predictions that turned out incorrect. Early 21st century people do not know one way or the other what will be possible in the future. However, the scientific claims of transhumanism still need to be examined critically, because some of these technoscientific prophecies may not be plausible; after we got to the moon, people expected we'd have a permanent colony there by the end of the century.
While frequently dismissed as mere speculation at best by most rationalists (especially in light of the many failures of artificial intelligence), transhumanism is a strongly-held belief among many computer geeks, notably synthesizer and accessible computing guru Ray Kurzweil, a believer in the "technological singularity," where technology evolves beyond humanity's current capacity to understand or anticipate it, and Sun Microsystems founder and Unix demigod Bill Joy, who believes the inevitable result of AI research is the obsolescence of humanity.
Certain recent technological advances are making the possibility of the realization of transhumanism appear more plausible: Scientists funded by the military developed an implant that can translate motor neuron signals into a form that a computer can use, thus opening the door for advanced prosthetics capable of being manipulated like biological limbs and producing sensory information. This is on top of the earlier development of cochlear implants, which translate sound waves into nerve signals; they are often called "bionic ears."
Even DIY transhumanism or 'biohacking' is becoming an option, with people installing magnetic implants, allowing them to feel magnetic and electric fields. Others have taken to wearing belts of magnets, in order to always be able to find magnetic north. Prosthetic limbs with some level of touch are also now being developed, a major milestone. One notable individual whose received magnetic finger implants is Zoe Quinn;  the current scientific consensus seems unclear, although humans are not thought to have a magnetic sense, there is a cryptochrome protein in the eye which could potentially make humans capable of Magnetoreception, like certain other mammals such as mice and cows appear to be. 
"Whole brain emulation" (WBE) is a term used by transhumanists to refer to, quite obviously, the emulation of a brain on a computer. While this is no doubt a possibility, it encounters two problems that keep it from being a certainty anytime in the near future.
The first is a philosophical objection: For WBE to work, "strong AI" (i.e. AI equivalent to or greater than human intelligence) must be attainable. A number of philosophical objections have been raised against strong AI, generally contending either that the mind or consciousness is not computable or that a simulation of consciousness is not equivalent to true consciousness (whatever that is). There is still controversy over strong AI in the field of philosophy of mind.
A second possible objection is technological: WBE may not defy physics, but the technology to fully simulate a human brain (in the sense meant by transhumanists, at least) is a long way away. Currently, no computer (or network of computers) is powerful enough to simulate a human brain. Henry Markram, head of the Blue Brain Project, estimates that simulating a brain would require 500 petabytes of data for storage and that the power required to run the simulation would cost about $3 billion annually. (However, in 2008, he optimistically predicted this it would be possible ten years from 2008.)) In addition to technological limitations in computing, there are also the limits of neuroscience. Neuroscience currently relies on technology that can only scan the brain at the level of gross anatomy (e.g., fMRI, PET). Forms of single neuron imaging (SNI) have been developed recently, but they can only be used on animal subjects (usually rats) because they destroy neural tissue.
First, let me say that Im all in favor of research on aging, and I think science has great potential to prolong healthy livesand Im all for that. But I think immortality, or even a close approximation to it, is both impossible and undesirable.
Another transhumanist goal is mind uploading, which is one way they claim we will be able to achieve immortality. Aside from the problems with WBE listed above, mind uploading suffers a philosophical problem, namely the "swamp man problem." That is, will the "uploaded" mind be "you" or simply a copy or facsimile of your mind? However, one possible way round this problem would be via incremental replacement of parts of the brain with their cybernetic equivalents (the patient being awake during each operation). Then there is no "breaking" of the continuity of the individual's consciousness, and it becomes difficult for proponents of the "swamp man" hypothesis to pinpoint exactly when the individual stops being "themselves." It does, however, run directly into a similar problem, the "Ship of Theseus" problem: when all of the brain parts are replaced, is it still fundamentally the same as the original?
Cryonics is another favorite of many transhumanists. In principle, cryonics is not impossible, but the current form of it is based largely on hypothetical future technologies and costs substantial amounts of money.
Fighting aging and extending life expectancy is possible the field that studies aging and attempts to provide suggestions for anti-aging technology is known as "biogerontology". Aubrey de Grey has proposed a number of treatments for aging. In 2005, 28 scientists working in biogerontology signed a letter to EMBO Reports pointing out that de Grey's treatments had never been demonstrated to work and that many of his claims for anti-aging technology were extremely inflated. This article was written in response to a July 2005 EMBO reports article previously published by de Grey and a response from de Grey was published in the same November issue. De Grey summarizes these events in "The biogerontology research community's evolving view of SENS," published on the Methuselah Foundation website.
Worst of all, some transhumanists outright ignore[citationneeded] what people in the fields they're interested in tell them; a few AI boosters, for example, believe that neurobiology is an outdated science because AI researchers can do it themselves anyway. They seem to have taken the analogy used to introduce the computational theory of mind, "the mind (or brain) is like a computer", and taken it literally. Of course, the mind/brain is not a computer in the usual sense. Debates with such people can take on the wearying feel of a debate with a creationist or climate change denialist, as such people will stick to their positions no matter what. Indeed, many critics are simply dismissed as Luddites or woolly-headed romantics who oppose scientific and technological progress.
Transhumanism has often been criticized for not taking ethical issues seriously on a variety of topics, including life extension technology, cryonics, and mind uploading and other enhancements. Francis Fukuyama (in his doctrinaire neoconservative days) caused a stir by naming transhumanism "the world's most dangerous idea." One of Fukuyama's criticisms, that implementation of the technologies transhumanists push for will lead to severe inequality, is a rather common one.
A number of political criticisms of transhumanism have been made as well. Transhumanist organizations have been accused of being in the pocket of corporate and military interests. The movement has been identified with Silicon Valley due to the fact that some of its biggest backers, such as Peter Thiel (of PayPal and Bitcoin fame), reside in the region. Some writers see transhumanism as a hive of cranky and obnoxious techno-libertarianism. The fact that Julian Huxley coined the term "transhumanism" and many transhumanists' obsession with constructing a Nietzschean ubermensch known as the "posthuman" has led to comparisons with eugenics. Like eugenics, it has been characterized as a utopian political ideology. Jaron Lanier slammed it as "cybernetic totalism".
Some tension has developed between transhumanism and religion, although there are many secular liberal people who are skeptical or opposed to transhumanism as well.[citationneeded] Some transhumanists, generally being atheistic naturalists, see all religion as an impediment to scientific and technological advancement and some Christians oppose transhumanism because of its stance on cloning and genetic engineering and label it as a heretical belief system. Other transhumanists, however, have attempted to extend an olive branch to Christians,  and the Christian Transhumanist Association group on Facebook has over 1,100 members.
Some religious transhumanists have tried to reconcile their religion and techno-utopian beliefs, calling for a "scientific theology." There is even a Mormon transhumanist organization. Ironically for the atheistic transhumanists, the movement has itself been characterized as a religion and its rhetoric compared to Christian apologetics. Interestingly the word transhuman first appeared in Henry Francis Careys 1814 translation of Paradiso, the last book of the Divine Comedy as Dante ascends to heaven during the resurrection. 
The very small transhumanist political movement has gained momentum with Zoltan Istvan announcing his bid for US president, with the Transhumanist Party and other small political parties gaining support internationally.
The important thing about transhumanism is that while a lot of such predictions may in fact be possible (and may even be in their embryonic stages right now), a strong skeptical eye is required for any claimed prediction about the fields it covers. When evaluating such a claim, one will probably need a trip to a library (or Wikipedia, or a relevant scientist's home page) to get up to speed on the basics.[note 1]
A common trope in science fiction for decades is that the prospect of transcending the current form may be positive, as in Arthur C. Clarke's 1953 novel Childhood's End or negative, as in the film The Matrix, with its barely disguised salvationist theme, or the Terminator series of films, where humanity has been essentially replaced by machine life. Change so radical elicits fear and thus it is unsurprising that many of the portrayals of transhumanism in popular culture are negative. The cyberpunk genre deals extensively with the theme of a transhumanist society gone wrong.
On closer inspection, this should not be surprising. Since transhumanism is ambitious about conquering age-related illnesses (extropianism), death (immortalism), ecological damage (technogaianism), gender differences (postgenderism) and suffering (abolitionism), a fictional world where this has already been achieved leaves a story with few plot devices to exploit. Additionally, it could be hard for the public to identify with flawless, post-human characters.
Among the utopian visions of transhumanism are those found in the collaborative online science fiction setting Orion's Arm. Temporally located in the post-singularity future, 10,000 years from now, Orion's Arm is massively optimistic about genetic engineering, continued improvements in computing and materials science. Because only technology which has been demonstrated to be impossible is excluded, even remotely plausible concepts has a tendency to be thrown in. At the highest end of the scale is artificial wormhole creation, baby universes and inertia without mass. Perhaps the only arguably positive depiction of transhumanism in video games is the Megaman ZX series where the line between human and reploids has begun to blur. Defining at what point the definition of the singularity was met in the centuries long Megaman timeline can be a useful way of illustrating how nebulous the terminology is during a debate.
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