Diagnostic Protocols and Alternative Treatment Options for Male Hypogonadism
Presented at the 13th Clinical Applications for Age Management Medicine, November 2012, Las Vegas, NV Rethinking the Hypothalamic-Pituitary-Gonadal Axis Unde...
By: AgeManagmentMedicine
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Diagnostic Protocols and Alternative Treatment Options for Male Hypogonadism - Video
Male hypogonadism Prof Ossama Fouda
Male hypogonadism Prof Ossama Fouda.
By: mansvu
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Group 6 Mafia Presents: Opioid-Induced Hypogonadism
Dr. Natty Light gets the exclusive with Jay-Z and Beyonce on their drug-therapy problems.
By: Taylor Howell
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Hypogonadism ¦ Treatment and Symptoms
XXXXXX #9669; Hypogonadism treatment mdash; Finding the right information about Hypogonadism treatment symptoms, is crucial to managing Hypogonadism. Learn more abou...
By: MainMDcom
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A cloud of suspicion hangs ominously over the heads of athletes in the UFC, their accomplishments viewed by many through the lens of performance-enhancing drug usage.
The use of PEDs is believed to be widespread throughout professional and high-level amateur sports, but even clean athletes whose accomplishments are the result of their athletic ability, hard work and perseverance, are tainted by the mess.
Little is done to stop the usage in combat sports. Postfight drug testing catches some users, but most experts say it nabs only those who don't understand how to mask their usage.
In fighting, there is no regularly scheduled regimen in which an athlete has to report his or her whereabouts to a testing agency in order to be randomly checked within 24 hours.
So, every time a fighter wins, there is plenty of suspicion that it involved artificial assistance. UFC middleweight contender Vitor Belfort is the latest to feel the backlash. Dan Henderson dodges a punch thrown by Lyoto Machida. (USA Today)
Since it was learned he's been on TRT, Belfort has scored several highlight-reel knockouts and become a legitimate title contender. He's been pressed about the issue so much that he suggested someone beat up the reporter asking about it, a thoughtless move for which he later apologized.
UFC light heavyweight Dan Henderson, who has had an exemption to use testosterone replacement therapy since 2007, said he believes there is a heavy amount of PED usage in the fight game.
"I think there is a decent amount [of PED usage in MMA]," said Henderson, a member of the 1992 and 1996 U.S. Olympic wrestling teams who will fight Rashad Evans in the main event of UFC 161 at the MTS Centre in Winnipeg on Saturday. "Just like at the top level of any sport, there is a decent amount of it. Guys look for that edge."
Henderson is one of a handful of fighters who have been given a therapeutic use exemption (TUE) to partake in testosterone replacement therapy (TRT). Henderson was diagnosed with hypogonadism, leading to his TUE
There are a number of causes of hypogonadism, or low testosterone, including previous steroid usage. Dr. Jonathan Gelber, an orthopedic surgeon who writes the Fight Medicine blog estimated that approximately 1 percent of the population between 18 and 40 who have not used anabolic steroids would be hypogonadal.
Read more:
Legitimate TRT user Dan Henderson pushing for Olympic-style drug testing in MMA
A cloud of suspicion hangs ominously over the heads of athletes in the UFC, their accomplishments viewed by many through the lens of performance-enhancing drug usage.
The use of PEDs is believed to be widespread throughout professional and high-level amateur sports, but even clean athletes whose accomplishments are the result of their athletic ability, hard work and perseverance, are tainted by the mess.
Little is done to stop the usage in combat sports. Post-fight drug testing catches some users, but most experts say it nabs only those who don't understand how to mask their usage.
In fighting, there is no regularly scheduled regimen in which an athlete has to report his or her whereabouts to a testing agency in order to be randomly checked within 24 hours.
So, every time a fighter wins, there is plenty of suspicion that it involved artificial assistance. UFC middleweight contender Vitor Belfort is the latest to feel the backlash.
Since it was learned he's been on TRT, Belfort has scored several highlight-reel knockouts and become a legitimate title contender. He's been pressed about the issue so much that he suggested someone beat up the reporter asking about it, a thoughtless move for which he later apologized.
UFC light heavyweight Henderson, who has had an exemption to use testosterone replacement therapy since 2007, said he believes there is a heavy amount of PED usage in the fight game.
"I think there is a decent amount [of PED usage in MMA]," said Henderson, a member of the 1992 and 1996 US Olympic wrestling teams who will fight Rashad Evans in the main event of UFC 161 at the MTS Centre in Winnipeg on Saturday. "Just like at the top level of any sport, there is a decent amount of it. Guys look for that edge."
Henderson is one of a handful of fighters who have been given a therapeutic use exemption (TUE) to partake in testosterone replacement therapy (TRT). Henderson was diagnosed with hypogonadism, leading to his TUE
There are a number of causes of hypogonadism, or low testosterone, including previous steroid usage. Dr. Jonathan Gelber, an orthopedic surgeon who writes the Fight Medicine blog estimated that approximately 1 percent of the population between 18 and 40 who have not used anabolic steroids would be hypogonadal.
See the original post:
Mixed Martial Arts - Henderson pushing for Olympic-style drug testing in MMA
BAUDETTE, Minn.--(BUSINESS WIRE)--
BioSante Pharmaceuticals, Inc. (BPAX) announced today that on June 20, 2013, it received a letter from NASDAQ informing BioSante that, since the merger with ANIP Acquisition Company d/b/a ANI Pharmaceuticals, Inc. (ANI) constituted a business combination resulting in a change of control under Listing Rule 5110(a), BioSante was required to meet the initial listing criteria for the NASDAQ Global Market. The letter continued that, since BioSante did not meet the minimum $4 bid price requirement for initial listings under Listing Rule 5405(a)(1), NASDAQ had determined to delist BioSantes securities, and that BioSante could appeal this determination.
As part of its preparations for the merger, BioSante anticipated the delisting letter and intends to appeal the determination and request a hearing before the NASDAQ Hearings Panel. This hearing request, if made within the required timeframe, would mean that BioSantes securities remain listed at least until the panel renders its decision.
In the meantime, to address the bid price deficiency, the Company intends to hold, as soon as practicable, a special meeting of its stockholders to approve a reverse split of its common stock, among other matters. The purpose would be to increase the per share market price for the common stock to a level greater than the minimum $4 bid price in order to regain compliance with the NASDAQ Listing Rules.
Important Additional Information for Stockholders
This communication in this press release does not constitute a solicitation of any vote or approval. In connection with the proposed reverse split, BioSante is filing with the SEC a proxy statement, the definitive version of which will be sent to the stockholders of BioSante. Stockholders are urged to read the proxy statement (including any amendments or supplements) and other documents filed with the SEC carefully in their entirety when they become available because they will contain important information about BioSante and the proposed reverse split.
Stockholders will be able to obtain free copies of the proxy statement (when available) and other documents filed with the SEC on the SECs web site at http://www.sec.gov. Free copies of the proxy statement (when available) and other documents filed with the SEC also can be obtained by directing a request to BioSante, Attention: Investor Relations, telephone: (218) 634-3500. In addition, stockholders may access copies of the documents filed with the SEC by BioSante on BioSantes website at http://www.biosantepharma.com.
BioSante and its directors and executive officers and other persons may be deemed to be participants in the solicitation of proxies in respect of the proposed reverse stock split. Information regarding BioSantes directors and executive officers is available in BioSantes joint proxy statement/prospectus filed with the SEC on May 8, 2013.
About BioSante and ANI
BioSante is an integrated specialty branded and generic pharmaceutical company developing, manufacturing, and marketing branded and generic prescription pharmaceuticals through its wholly-owned subsidiary, ANI. In two facilities with combined manufacturing, packaging and laboratory capacity totaling 173,000 square feet, ANI manufactures oral solid dose products, as well as liquids and topicals, including narcotics and those that must be manufactured in a fully contained environment due to their potency and/or toxicity. ANI also performs contract manufacturing for other pharmaceutical companies. Over the last two years ANI has launched three new products and has eleven products in development. ANIs targeted areas of product development include narcotics, anti-cancers and hormones (potent compounds), and extended release niche generic product opportunities. BioSantes other products include an FDA-approved testosterone gel for male hypogonadism, which is licensed to Teva Pharmaceuticals USA, Inc. For more information please visit our websites, http://www.biosantepharma.com and http://www.anipharmaceuticals.com.
Originally posted here:
BioSante Pharmaceuticals Receives NASDAQ Delisting Determination Letter
The US Food and Drug Administration (:FDA) recently issued a complete response letter (CRL) for Endo Health Solutions (ENDP) new drug application on Aveed. The company is looking to get Aveed (a long-acting testosterone undecanoate injection) approved as a treatment for male hypogonadism.
The FDA declined to approve the new drug application for Aveed in the present form, as it is apprehensive about the risks and complications which may emanate after the injection of the drug. While issuing the CRL, the US regulatory body asked Endo to develop a medication guide. Specifically, the FDA asked Endo to ensure that the Risk Evaluation and Mitigation Strategy includes the guide in addition to Elements to Assure Safe Use to address the safety issue mentioned above.
However, the US regulatory body did not ask the company to conduct additional studies on Aveed. The requirement of additional trials would have pushed up its research and development costs. Endo intends to respond to the CRL by the end of the third quarter of 2013.
We note that the Aveed setback is not the first one for Endo this year. Last month, Endo suffered a blow with the FDA turning down its request to prevent the entry of generic versions of its painkiller, Opana ER. The decision by the FDA implies that the generic formulations of the original version of Opana ER will continue to be available in the market.
Endo expects the FDA decision to impact its 2013 guidance adversely. The company expects the adverse FDA ruling to reduce 2013 total net sales of Opana ER by up to $120 million. Moreover, Endos 2013 adjusted earnings per share outlook is expected to be hurt by approximately 55 cents following the FDA verdict.
While announcing its first-quarter 2013 results, Endo stated that it expects adjusted earnings per share for 2013 in the range of $4.40$4.70 per share and revenues of $2.80$2.95 billion. The Zacks Consensus Estimate for 2013 pegs earnings at $4.31 per share on revenues of $2.8 billion. Endo intends to throw more light on its 2013 guidance in the coming months.
Moreover, another painkiller at Endo, Lidoderm is expected to face generic competition later in the year from Actavis, Inc. (ACT). This will hamper sales of the drug significantly.
Endo currently carries a Zacks Rank #3 (Hold). Jazz Pharmaceuticals (JAZZ) and Santarus, Inc. (SNTS) appear to be more attractive with a Zacks Rank #1 (Strong Buy) each.
Read the Full Research Report on ACT
Read the Full Research Report on SNTS
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August 21st, 2013
Andropause is the technical term for the hormone imbalance all men will experience as they age. Commonly called male menopause, andropause typically begins to affect men between the ages of 35 and 40. In some cases, however, the testosterone deficiencies associated with andropause may occur in much younger men.
Whatever your age, as a man you need testosterone to maintain energy and focus, to build lean muscle, to boost your sex drive, and to regulate your moods. In other words, the onset of andropause (and the drop in testosterone that goes with it) can have a big impact on the quality of your personal and professional life. In fact, upon entering andropause, many men say they just dont feel like themselves anymore.
Andropause occurs as men get older, primarily because our glands slow down and stop producing adequate levels of hormone. The result is hormone imbalance. In particular, testosterone, thyroid and DHEA levels decline. Meanwhile, estrogen levels often increasenot a good thing for a man.
The following are some of the more common symptoms of andropause:
While testosterone decline is something that will happen to every man as he gets older, that doesnt mean we have to accept it. So long as its done correctly, hormone levels can be safely and effectively restored via hormone therapy. Men of any age can benefit, and results can generally be seen in 4 to 6 weeks. Its important to note, however, that for hormone therapy to be effective, it must go hand-in-hand with a healthy diet, regular exercise, and stress management.
Call Renew Man to find out how we can help you to get our life back. All of our doctors are experts when it comes to treating hormone imbalance in men, and Renew Man is set up to make things easy and convenient for you. Let us impress you with our knowledge, and give us a call. You can reach us at 800-859-7511.
See more here:
What Is Andropause? It's Symptoms In Men & Treatment - Renew Man
MALVERN, Pa., May 30, 2013 /PRNewswire/ --Endo Pharmaceuticals Inc., a subsidiary of Endo Health Solutions Inc. (ENDP) announced today that the U.S. Food and Drug Administration (FDA) has issued a complete response letter regarding the New Drug Application (NDA) for Endo's long-acting testosterone undecanoate injection, AVEED, for men diagnosed with hypogonadism.
The complete response letter did not include requests for the company to perform additional clinical studies. The FDA outlined the steps necessary to support approval of the NDA and updated the requirement for a Risk Evaluation and Mitigation Strategy (REMS). Specifically, the FDA has requested that the REMS include a Medication Guide as well as Elements to Assure Safe Use (ETASU) to mitigate the risks and severe complications related to post-injection reactions.
"We are encouraged by the feedback received from the FDA in the complete response and appreciate the clarity around the path forward for AVEED," said Ivan Gergel, executive vice president of research and development and chief scientific officer of Endo Health Solutions. "We plan to submit a complete response by the end of the third quarter of 2013. We look forward to making this treatment option available to appropriate male patients in the U.S. diagnosed with hypogonadism."
About Endo
Endo Health Solutions Inc. (Endo) is a U.S.-based diversified healthcare company that is redefining healthcare value by finding solutions for the unmet needs of patients along care pathways for pain management, pelvic health, urology, endocrinology and oncology. Through our operating companies: AMS, Endo Pharmaceuticals, HealthTronics and Qualitest, Endo is dedicated to improving care through a combination of branded products, generics, devices, technology and services that creates value for patients, providers and payers alike. Learn more at http://www.endo.com.
Safe Harbor Statement
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Statements including words such as "believes," "expects," "anticipates," "intends," "estimates," "plan," "will," "may," "look forward," "intend," "guidance," "future" or similar expressions are forward-looking statements. Because these statements reflect our current views, expectations and beliefs concerning future events, these forward-looking statements involve risks and uncertainties. Investors should note that many factors, as more fully described under the caption "Risk Factors" in our Form 10-K, Form 10-Q and Form 8-K filings with the Securities and Exchange Commission and as otherwise enumerated herein or therein, could affect our future financial results and could cause our actual results to differ materially from those expressed in forward-looking statements contained in our Annual Report on Form 10-K. The forward-looking statements in this press release are qualified by these risk factors. These are factors that, individually or in the aggregate, could cause our actual results to differ materially from expected and historical results. We assume no obligation to publicly update any forward-looking statements, whether as a result of new information, future developments or otherwise.
More here:
Endo Pharmaceuticals Provides Regulatory Update On AVEEDâ„¢ (Testosterone Undecanoate) Injection
August 21st, 2013
Andropause is the technical term for the hormone imbalance all men will experience as they age. Commonly called male menopause, andropause typically begins to affect men between the ages of 35 and 40. In some cases, however, the testosterone deficiencies associated with andropause may occur in much younger men.
Whatever your age, as a man you need testosterone to maintain energy and focus, to build lean muscle, to boost your sex drive, and to regulate your moods. In other words, the onset of andropause (and the drop in testosterone that goes with it) can have a big impact on the quality of your personal and professional life. In fact, upon entering andropause, many men say they just dont feel like themselves anymore.
Andropause occurs as men get older, primarily because our glands slow down and stop producing adequate levels of hormone. The result is hormone imbalance. In particular, testosterone, thyroid and DHEA levels decline. Meanwhile, estrogen levels often increasenot a good thing for a man.
The following are some of the more common symptoms of andropause:
While testosterone decline is something that will happen to every man as he gets older, that doesnt mean we have to accept it. So long as its done correctly, hormone levels can be safely and effectively restored via hormone therapy. Men of any age can benefit, and results can generally be seen in 4 to 6 weeks. Its important to note, however, that for hormone therapy to be effective, it must go hand-in-hand with a healthy diet, regular exercise, and stress management.
Call Renew Man to find out how we can help you to get our life back. All of our doctors are experts when it comes to treating hormone imbalance in men, and Renew Man is set up to make things easy and convenient for you. Let us impress you with our knowledge, and give us a call. You can reach us at 800-859-7511.
Originally posted here:
http://www.renewman.com
August 21st, 2013
Andropause is the technical term for the hormone imbalance all men will experience as they age. Commonly called male menopause, andropause typically begins to affect men between the ages of 35 and 40. In some cases, however, the testosterone deficiencies associated with andropause may occur in much younger men.
Whatever your age, as a man you need testosterone to maintain energy and focus, to build lean muscle, to boost your sex drive, and to regulate your moods. In other words, the onset of andropause (and the drop in testosterone that goes with it) can have a big impact on the quality of your personal and professional life. In fact, upon entering andropause, many men say they just dont feel like themselves anymore.
Andropause occurs as men get older, primarily because our glands slow down and stop producing adequate levels of hormone. The result is hormone imbalance. In particular, testosterone, thyroid and DHEA levels decline. Meanwhile, estrogen levels often increasenot a good thing for a man.
The following are some of the more common symptoms of andropause:
While testosterone decline is something that will happen to every man as he gets older, that doesnt mean we have to accept it. So long as its done correctly, hormone levels can be safely and effectively restored via hormone therapy. Men of any age can benefit, and results can generally be seen in 4 to 6 weeks. Its important to note, however, that for hormone therapy to be effective, it must go hand-in-hand with a healthy diet, regular exercise, and stress management.
Call Renew Man to find out how we can help you to get our life back. All of our doctors are experts when it comes to treating hormone imbalance in men, and Renew Man is set up to make things easy and convenient for you. Let us impress you with our knowledge, and give us a call. You can reach us at 800-859-7511.
See original here:
What is Andropause? - Renew Youth
Some men develop depression,loss of sex drive, erectile dysfunction and other physical and emotional symptomswhen they reach their late 40s to early 50s.
Other symptoms common in men this ageare:
These symptoms can interfere with everyday life and happiness, so it's important tofind the underlying cause and work out what can be done to resolve it.
The "male menopause" (sometimes called the "andropause") is an unhelpful term sometimes used in the media to explain the above symptoms.
This label ismisleading because it suggests the symptoms are the result of a suddendrop in testosterone in middle age, similar to what occurs in the female menopause. This isn't true. Although testosterone levels fall as men age, the decline is steadyless than 2% a year from around the age of 30-40and this is unlikely to cause any problems in itself.
A testosterone deficiency that develops later in life (also known as late-onset hypogonadism) can sometimesbe responsible for these symptoms, but in many cases the symptoms are nothing to do withhormones.
Lifestyle factors or psychological problems are often responsible for many of the symptoms described above.
For example,erectile dysfunction,loss of libidoandmood swingsmay bethe result of either:
There are alsophysical causes of erectile dysfunction, such as changes in the blood vessels, which may happen alongside any psychological cause.
Read about the causes of erectile dysfunction.
Psychological problems are typically brought on by workor relationship issues, divorce,money problems or worrying about ageing parents.
A "midlife crisis" can also be responsible. Thiscan happen when men think they've reached life's halfway stage. Anxieties over what they've accomplished so far, either in their job or personal life, can lead to a period of depression.
Read more about the male midlife crisis.
Other possible causes of the above symptoms include:
In some cases, where lifestyle or psychological problems don't seem to be responsible, the symptoms of the "male menopause" may bethe result ofhypogonadism, wherethe testes produce few or no hormones.
Hypogonadism issometimes present from birth,which can cause symptoms like delayed puberty and small testes.
Hypogonadism can also occasionallydevelop later in life, particularly in men who are obese or have type 2 diabetes. This is known aslate-onset hypogonadism and it can cause the "male menopause" symptoms mentioned above. However, this is an uncommon and specific medical condition that isn't a normal part of ageing.
A diagnosis oflate-onset hypogonadism can usually be made based on your symptoms and the results of blood testsused tomeasure your testosterone levels.
If you're experiencing any of the above symptoms, see your GP. They'll ask about your work and personal life, to see if your symptoms may be caused by a mental health issue, such as stress or anxiety.
If stress or anxiety are affecting you, you may benefit from medication or a talking therapy, such as cognitive behavioural therapy (CBT). Exercise and relaxation can also help.Read about:
Your GP may also order ablood test to measure your testosterone levels. If the results suggest you have a testosterone deficiency, you may be referred to an endocrinologist (a specialist in hormone problems).
If the specialist confirms this diagnosis,youmay be offered testosterone replacementto correct the hormone deficiency, which should relieve your symptoms. This treatment may be either:
Page last reviewed: 08/04/2016
Next review due: 08/04/2018
Excerpt from:
Male menopause - NHS Choices
Un article de Wikipdia, l'encyclopdie libre.
Le dficit andrognique li l'ge (DALA) ou andropause est un phnomne biologique, analogue la mnopause de la femme, qui peut affecter les hommes entre quarante et cinquante-cinq ans. linverse des femmes, les hommes nont pas de jalon net comme la cessation des menstruations pour marquer cette transition. Tous deux, toutefois, se caractrisent par une baisse des niveaux hormonaux. Les strognes chez la femme, la testostrone chez lhomme. Les changements corporels surviennent trs graduellement chez lhomme et peuvent tre accompagns de changements dattitudes et dhumeurs, de fatigue, de perte dnergie, dapptit sexuel et dagilit physique.
Des tudes montrent que ce dclin en testostrone peut fragiliser les hommes avec pour consquence des problmes de sant tels que les maladies cardiaques et la fragilisation des os.
L'andropause a t dcrite dans la littrature mdicale pour la premire fois dans les annes 1940, mais notre capacit la diagnostiquer est relativement rcente. Les tests diagnostiques, indisponibles jusqu' la premire dcennie du XXIesicle, ont permis l'andropause de rester un sujet de dbat parmi les endocrinologues et les professionnels de la sant masculine. L'ide que l'homme g, l'instar de la femme, puisse tre sujet des fluctuations d'hormones sexuelles a t difficile accepter. Aujourd'hui, l'intrt pour l'andropause crot parmi les chercheurs spcialiss en grontologie. Une acceptation inconteste ncessite davantage d'investigation.
Le terme andropause est critiqu car implique une dichotomie (le patient est en andropause ou ne l'est pas) ce qui ne reflte pas la ralit. Le terme hypogonadisme est ainsi prfr par plusieurs socits savantes[1].
Le niveau de testostrone dcrot chez l'homme partir de trente ans, et de 10% par dcennie. Dans le fonctionnement normal du systme hormonal masculin, la majeure partie de la testostrone est lie deux composants sanguins, la SHBG (sex hormone-binding globulin) et l'albumine qui la transportent et participent sa rgulation. Ils se partagent ainsi entre 97 98%, privant les tissus. Quant aux 2 3% restants, ils sont dits biodisponibles ou testostrone libre. En outre, les sites o la testostrone doit se lier pour tre efficace peuvent tre occups par l'estradiol, strogne prsente aussi chez l'homme qui augmente avec l'ge et le poids. Au-del de soixante ans, une carence en testostrone est frquente.
Leur qualit de vie amoindrie, les hommes de plus de cinquante ans consultent de plus en plus frquemment, se plaignant de ne plus tre l'homme qu'ils taient. Une tude europenne en 2010 estime que 2% de la population tudie est concerne, les insuffisances majeures tant diagnostiques chez 20% des plus de soixante ans (les chiffres de 30% des quinquagnaires sont ceux avancs par le march des rectiles).
Jusqu' rcemment, l'andropause tait mal identifie; les symptmes taient vagues et variaient grandement d'un individu l'autre:
La diminution de production de l'hormone mle est trs progressive: elle dbute vers trente ans et s'tale jusqu'au dcs sur les trois, quatre ou cinq dcennies suivantes. Elle diminue de 1% par an partir de l'ge de cinquante ans, les insuffisances majeures tant diagnostiques chez 20% des plus de soixante ans. Elle n'est pas toujours symptomatique. Aussi, un homme peut vivre de manire optimale au tiers ou la moiti du taux sanguin d'un autre.
En 2010, un questionnaire et diffrents examens biologiques sont raliss sur 3369 hommes gs entre 40 et 79 ans vivant dans huit pays europens: l'tude statistique rvle que sur les 32 symptmes potentiels pouvant tre a priori retenus, neuf, lis une diminution des niveaux de testostrone, ont t slectionns par les chercheurs. Parmi les plus importants: rduction de la frquence des rections du petit matin, effacement progressif des penses avec connotation sexuelle, rduction de la qualit des rections, existence d'une sensation de fatigue, incapacit avoir une activit physique minimale ainsi que des symptmes dpressifs (perte de tonus, sensation de tristesse). Les auteurs de cette tude ont conclu que la prsence de trois de ces symptmes sexuels combins de bas niveaux de testostrone (taux de testostrone totale infrieur 11nmoll-1 et taux de testostrone libre infrieur 220pmoll-1) tait requise pour diagnostiquer l'hypogonadisme chez les hommes plus gs[2].
L'andropause est lie des niveaux de testostrone bas. Tout homme en fait l'exprience, certains davantage. Alors que le concept du niveau normal de testostrone est sujet interprtation, un niveau total de testostrone dans le srum sanguin au-dessus de 350nanogrammes par dcilitre (12nmoll-1) est normal et ne requiert pas de traitement. Un taux infrieur 20ngml-1 (8nmoll-1) peut bnficier d'un traitement[3]. Une valeur intermdiaire porte discussion et mrite d'tre rpt, une supplmentation systmatique dans ces cas n'ayant pas apport la preuve d'une efficacit[4]. Un taux de testostrone libre en de de 6,0picogrammes par millilitre peut faire discuter galement un traitement.
L'apport d'un complment de testostrone sous supervision mdicale est simple: par injection, gel, patch ou cartouche implante. La difficult rside dans le dosage. Lhormonothrapie la testostrone pourrait accrotre la libido, amliorer la qualit des rections, augmenter le niveau dnergie, affermir les muscles et pourrait contribuer une meilleure densit minrale osseuse. La testostrone pourrait aussi retarder le processus de vieillissement. Un excs de testostrone peut, par contre, avoir des effets dplaisants, voire dangereux. Il y aurait un risque potentiellement accru dhypertrophie bnigne de la prostate, de cancer de la prostate (mme si cela n'a pas t formellement dmontr[5],[6]), de cancer du sein, de problmes au foie, dapne du sommeil et de caillots sanguins.
Il existe des contre-indications un apport de testostrone: maladie de la prostate, cancer du sein, hypertrophie musculaire ou problmes psychiatriques graves, apne du sommeil et troubles respiratoires importants.
Les gonadotrophines chorioniques sont des hormones extraites des urines de femmes enceintes qui possdent la proprit de raviver les scrtions des testicules. Ces hormones sont actives si et seulement si les testicules sont capables de rpondre. Elles ont un avantage : aprs deux trois mois de traitement, les testicules redmarrent. S'il y a rechute, une nouvelle cure est indispensable.
Lhormone de croissance stimule la croissance de lenfant et assure chez ladulte la fonction de restaurer les stocks de protines dtruites pendant lactivit de la journe sous leffet de la cortisone. Cette hormone pourrait donc aider le maintien de la musculature de lhomme prenant de lge.
Le sulfate de dhydropiandrostrone est une hormone mle qui est scrte par les glandes surrnales. Le traitement par le sulfate de DHEA pourrait ralentir le vieillissement. Le sulfate de DHEA aurait la capacit de rendre lhormone de croissance plus active. Son efficacit relle reste controverse.
La mlatonine est une hormone de la glande pinale qui permettrait de lutter efficacement contre les troubles du sommeil lis au vieillissement. Cette hormone aurait le pouvoir de ralentir le vieillissement artriel. Elle pourrait aussi stimuler le systme immunitaire dont lefficacit diminue avec lge. Certains chercheurs affirment que la mlatonine stimulerait aussi lactivit sexuelle.
Sur les autres projets Wikimedia:
See the article here:
Dficit andrognique li l'ge Wikipdia
Are you experiencing symptoms or Andropause, also known as Male Menopause? Well, you've come to the right place to find out more.
Men don't typically talk about not feeling well, and particularly not about life transitions such as male menopause. But when I began my sister site, Everything Menopause which covers womens menopause symptoms at http://www.everythingmenopause.com, I got more requests for Andropause information than I ever imagined.
Midlife doesn't have to be so difficult, and with some research and effort, you too can claim back the quality you so richly deserve in your life -- your good health!
There is so much available to us now that can help alleviate the uncomfortable symptoms of going through this transition.
Everything Andropause makes every attempt to bring you the most up-to-date information regarding the newest trends in treatment. We'll link you to people and places that should be able to answer all of your questions. If we don't know the answer, we'll find an expert who does.
If you want to subscribe to The Menopause Report, our monthly newsletter, just fill in the form on your left. You can unsubscribe any time.
Feel free to contact us and send us your personal stories to share in the newsletter, or your questions and comments any time.
We hope you find this site useful and come back often.
Read more:
Andropause | Male Menopause | Male Menopause Symptoms ...
Do men have a menopause?
Declining levels of testosterone and DHEA are commonly seen in men beginning in the fourth decade of life. These anabolic hormones are particularly important in men, as they are the major players in maintaining both physical and mental health. For example, they increase energy and decrease fatigue; they help in maintaining erectile function and normal sex drive; and they increase the strength of all structural tissues in the skin, bones, and muscles, including the heart. Proper levels of androgens also help to prevent depression and mental fatigue.
Yes, men do experience age-related changes in their hormone levels.
This hormonal decline, referred to as andropause, often coincides with symptoms of aging in males. The term andropause, named after the male hormones known as androgens, is the counterpart to menopause in women when production of estrogens and progesterone by the ovaries begins to decline. But, the drop is more gradual in men than the hormonal roller coaster so often experienced by women during menopause.
Stress management, exercise, proper nutrition, dietary supplements (particularly zinc and selenium), and androgen replacement therapy with physician guidance have all been shown to raise androgen levels in men and help to counter andropause symptoms.
Yes. Undiagnosed hormonal imbalances are often linked to increased risks for prostate disease, low sex drive, rapid aging, and poor quality of life in general. By having your hormones tested in saliva (Female/Male Saliva Profile I) or in blood spot (Male Blood Profiles I or II), one can identify the specific hormonal excesses and deficiencies associated with specific symptoms. Test results can facilitate safe, appropriate prescribing and adjustment of hormone therapy as needed.
For the best, most-comprehensive assessment of male hormone levels during the andropause years and/or for those men having suspected imbalances of thyroid and/or adrenal function, we recommend our Comprehensive Male Profile II. This profile tests all reproductive (sex) hormones, thyroid, and adrenal hormones with the added bonus of a PSA measurement (essential in men supplementing with testosterone to determine their prostate health status). We also provide a 5-hormone panel in saliva (Female/Male Saliva Profile I) that tests estradiol, progesterone, testosterone, DHEA-S, and cortisol levels. We also recommend Male Blood Profiles (I and II) in blood spot, both of which include: E2, T, SHBG, PSA, DS, C, estradiol, testosterone, SHBG, DHEA-S, and morning cortisol. Male Blood Profile II also tests our Complete Thyroid Profile (TSH, fT3, fT4, TPO).
Saliva testing can measure present hormone levels to identify the extent to which testosterone levels are low. Our test reports indicate an expected range enabling a person to compare his levels to the normal range. Saliva testing can also identify additional androgen hormone levels (such as DHEA-S and cortisol), which may contribute to a low testosterone reading. In blood spot, the level of testosterone available to the cells can be measured in concert with PSA, which is an important prerequisite for initiating testosterone supplementation. We can also provide informational materials for his physician and follow-up resources.
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Andropause (Male Menopause) - zrtlab.com
Note: Last month, I wrote a blog about foods for women in mid-life. After some -- heated -- commentary about my sexist approach to mid-life, I decided to cover the male aspect.
In 1944, researchers Carl Heller and Gordon Myers identified symptoms of what they termed "male climacteric," another word for menopause; these included loss of libido, depression, inability to concentrate, and sometimes hot flashes. The term "manopause" was later coined to describe the physical and emotional changes many men experience in their late 40s and early 50s. The popular media subsequently linked "manopause" to such 50-something male behaviors as buying a pricey sports car, changing careers, or hooking up with a younger woman.
While the phenomenon of a male menopause is debatable, the physical effect of reduced testosterone is very real. Testosterone is one of the primary male sex hormones, and it's crucial for the development of male reproductive tissues, building muscle, bone formation, normal sexual drive and stamina, and overall well-being. Starting around the age of 35, all men (and women) experience a gradual decline in the amount of testosterone their bodies produce; simultaneously, levels of sex-hormone-binding-globulin (SHBG) increase, further inhibiting testosterone.
By the time most men are in their 50s, testosterone levels are low enough to create a constellation of changes. This phenomenon is called "andropause," sometimes referred to as ADAM ("androgen deficiency in the aging male") or PADAM ("partial androgen deficiency in the aging male"). Some studies suggest that andropause is associated with increased risk of osteoporosis, heart disease, insulin resistance, and possibly Alzheimer's disease. More immediately noticeable effects of lower testosterone include weight gain, loss of libido, diminished mental acuity, reduced muscle bulk, depression, impaired memory and fatigue.
Not surprisingly, these changes dramatically affect a guy's emotional and spiritual well-being."Male menopause is a physical condition with psychological, interpersonal, social, and spiritual dimensions," says Jed Diamond, Ph.D., author of Male Menopause (Sourcebooks, 1998) and The Irritable Male Syndrome (Rodale Books, 2005). "Although this is a potent and multi-dimensional change of life, media often focus on the more superficial aspects of men leaving their older wives for a younger woman or changing careers." In Understanding Men's Passages (Ballantine Books, 1999), author Gail Sheehy says,"If menopause is the silent passage, male menopause is the unmentionable passage ... It strikes at the core of what it is to be a man ... his youthful sexual drive and performance."
Predictably enough, there's some controversy. Some say andropause is real, but "manopause" is a myth perpetuated by authors and companies to promote services and products designed to address the so-called male menopause. While few would argue that men lose testosterone as they age, it's an entirely different situation than menopause, some say, and has little to do with any perceived emotional or spiritual events. Unlike menopause, during which a woman's hormones decline suddenly and precipitously, the loss of testosterone is slow and gradual enough that most men don't notice the corresponding subtle changes. Say the authors of one study, "The extent to which an age-dependent decline in androgen levels leads to health problems that might affect or alter the quality of life remains under debate."
Whether andropause is a man's version of menopause replete with emotional, psychological and spiritual changes, or just a blip on the hormonal screen, may depend on your own circumstances and makeup. But if you're a guy (or you have a guy) who's experiencing some mid-life shakeups, some things you might consider:
Testosterone replacement therapy (also called TRT) can balance and replace testosterone levels and decrease the symptoms of andropause. Unlike estrogen or progesterone therapies, "pharmaceutical, prescription forms of testosterone, especially topical and pellet forms, are for the most part bio-identical," says Jennifer Landa, M.D., chief medical officer of BodyLogicMD in Orlando, Florida. "Even the injectable forms are very similar to bio identical." TRT can have side effects, and should be thoroughly discussed with your health care provider, especially if you're at risk for prostate cancer. Some natural supplements -- Tongkat ali, Tribulus terrestris, zinc, horny goat weed -- have shown promise too in easing symptoms of andropause.
Watch your weight. Testosterone can be converted to estrogen via an enzyme called aromatase. "Some men are genetically predisposed to more aromatase activity," says Landa, "but being heavy also has an impact, since aromatase is present to large degree in fat." And fat begets fat. "Lower testosterone as a result of aging means more muscle converts to fat," she says. "Then, having more fat means more testosterone is converted to estrogen. It's a really negative cycle of events."
Avoid estrogenic compounds. As testosterone levels naturally decrease with age, the ratio of testosterone to estrogen in a man's body falls. When men are exposed to additional sources of estrogen, it further upsets the balance of testosterone to estrogen. Endocrine disruptors and xenoestrogens from plastic food wraps, personal care products and conventionally raised meat and dairy are the most common sources. "These are just as important for men to avoid as for women, especially since they also increase the risk of prostate cancer," says Landa. To minimize exposure, choose organic, grass-fed or pastured animal products, avoid plastic food containers, and buy natural personal care products that are free of parabens and other chemicals.
Recognize the spiritual side. "During this stage, men have to look at all aspects of their lives, including the spiritual," says Diamond. "They may question old patterns and wonder, 'Now that I've done what I was supposed to do, what do I really want to do with my life while I still have time?'Many men have spent a lifetime on a career. Now they want to explore their calling, the deeper more spiritual aspect of what they do." Give yourself ample time and space to recognize these changes -- and be willing to go with deeper callings.
For more by Lisa Turner, click here.
For more on aging gracefully, click here.
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Andropause: When Guys Get 'The Change' | Lisa Turner
Urine is made in the kidneys, and travels down two tubes called ureters to the bladder. The bladder stores urine, allowing urination to be infrequent and voluntary. The bladder is lined by layers of muscle tissue that stretch to accommodate urine. The normal capacity of the bladder is 400 to 600 mL.
During urination, the bladder muscles contract, and two sphincters (valves) open to allow urine to flow out. Urine exits the bladder into the urethra, which carries urine out of the body. Because it passes through the penis, the urethra is longer in men (8 inches) than in women (1.5 inches).
A healthy bladder is important to all of us, yet many people suffer in silence even though a lot can be done to improve things. Take this very short assessment to find out if you should seek further advice. Note that while it is really very much basic, it may help you to see how much that is a problem to you and decide if any further medical assistance is needed.
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Andropause: Dealing With Male Menopause
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Andropause is real! The large percentage of men with low testosterone are not being treated for their andropause. These results are identical with what we have found in our Canadian clinic. If you or a loved one thinks they are suffering from low testosterone you or they should seek knowledgeable physicians like those at the Masters Men's Clinic for diagnosis, education and treatment.
Check out this recent article from Journal of the American Medical Association - click here
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Women in you life are invited to see if they may qualify for a medical research study for women concerned about their decreased sexual desire. The purpose of the study is to determine the effectiveness and safety of an investigational medication for Hypoactive Sexual Desire Disorder (HSDD).
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