Liberty – Wikipedia

Broadly speaking, liberty (Latin: Libertas) is the ability to do as one pleases.[1] In politics, liberty consists of the social, political, and economic freedoms to which all community members are entitled.[2] In philosophy, liberty involves free will as contrasted with determinism.[3] In theology, liberty is freedom from the effects of "sin, spiritual servitude, [or] worldly ties."[4]

Sometimes liberty is differentiated from freedom by using the word "freedom" primarily, if not exclusively, to mean the ability to do as one wills and what one has the power to do; and using the word "liberty" to mean the absence of arbitrary restraints, taking into account the rights of all involved. In this sense, the exercise of liberty is subject to capability and limited by the rights of others.[5] Thus liberty entails the responsible use of freedom under the rule of law without depriving anyone else of their freedom. Freedom is more broad in that it represents a total lack of restraint or the unrestrained ability to fulfill one's desires. For example, a person can have the freedom to murder, but not have the liberty to murder, as the latter example deprives others of their right not to be harmed. Liberty can be taken away as a form of punishment. In many countries, people can be deprived of their liberty if they are convicted of criminal acts.

The word "liberty" is often used in slogans, such as "life, liberty, and the pursuit of happiness"[6] or "Liberty, Equality, Fraternity".[7]

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Philosophers from earliest times have considered the question of liberty. Roman Emperor Marcus Aurelius (121180 AD) wrote:

a polity in which there is the same law for all, a polity administered with regard to equal rights and equal freedom of speech, and the idea of a kingly government which respects most of all the freedom of the governed.[8]

According to Thomas Hobbes (15881679):

a free man is he that in those things which by his strength and wit he is able to do is not hindered to do what he hath the will to do.

John Locke (16321704) rejected that definition of liberty. While not specifically mentioning Hobbes, he attacks Sir Robert Filmer who had the same definition. According to Locke:

In the state of nature, liberty consists of being free from any superior power on Earth. People are not under the will or lawmaking authority of others but have only the law of nature for their rule. In political society, liberty consists of being under no other lawmaking power except that established by consent in the commonwealth. People are free from the dominion of any will or legal restraint apart from that enacted by their own constituted lawmaking power according to the trust put in it. Thus, freedom is not as Sir Robert Filmer defines it: 'A liberty for everyone to do what he likes, to live as he pleases, and not to be tied by any laws.' Freedom is constrained by laws in both the state of nature and political society. Freedom of nature is to be under no other restraint but the law of nature. Freedom of people under government is to be under no restraint apart from standing rules to live by that are common to everyone in the society and made by the lawmaking power established in it. Persons have a right or liberty to (1) follow their own will in all things that the law has not prohibited and (2) not be subject to the inconstant, uncertain, unknown, and arbitrary wills of others.[9]

John Stuart Mill (18061873), in his work, On Liberty, was the first to recognize the difference between liberty as the freedom to act and liberty as the absence of coercion.[10] In his book Two Concepts of Liberty, Isaiah Berlin formally framed the differences between these two perspectives as the distinction between two opposite concepts of liberty: positive liberty and negative liberty. The latter designates a negative condition in which an individual is protected from tyranny and the arbitrary exercise of authority, while the former refers to the liberty that comes from self-mastery, the freedom from inner compulsions such as weakness and fear.

The modern concept of political liberty has its origins in the Greek concepts of freedom and slavery.[11] To be free, to the Greeks, was not to have a master, to be independent from a master (to live as one likes).[12] That was the original Greek concept of freedom. It is closely linked with the concept of democracy, as Aristotle put it:

This applied only to free men. In Athens, for instance, women could not vote or hold office and were legally and socially dependent on a male relative.[14]

The populations of the Persian Empire enjoyed some degree of freedom. Citizens of all religions and ethnic groups were given the same rights and had the same freedom of religion, women had the same rights as men, and slavery was abolished (550 BC). All the palaces of the kings of Persia were built by paid workers in an era when slaves typically did such work.[15]

In the Buddhist Maurya Empire of ancient India, citizens of all religions and ethnic groups had some rights to freedom, tolerance, and equality. The need for tolerance on an egalitarian basis can be found in the Edicts of Ashoka the Great, which emphasize the importance of tolerance in public policy by the government. The slaughter or capture of prisoners of war also appears to have been condemned by Ashoka.[16] Slavery also appears to have been non-existent in the Maurya Empire.[17] However, according to Hermann Kulke and Dietmar Rothermund, "Ashoka's orders seem to have been resisted right from the beginning."[18]

Roman law also embraced certain limited forms of liberty, even under the rule of the Roman Emperors. However, these liberties were accorded only to Roman citizens. Many of the liberties enjoyed under Roman law endured through the Middle Ages, but were enjoyed solely by the nobility, rarely by the common man.[citation needed] The idea of inalienable and universal liberties had to wait until the Age of Enlightenment.

The social contract theory, most influentially formulated by Hobbes, John Locke and Rousseau (though first suggested by Plato in The Republic), was among the first to provide a political classification of rights, in particular through the notion of sovereignty and of natural rights. The thinkers of the Enlightenment reasoned that law governed both heavenly and human affairs, and that law gave the king his power, rather than the king's power giving force to law. This conception of law would find its culmination in the ideas of Montesquieu. The conception of law as a relationship between individuals, rather than families, came to the fore, and with it the increasing focus on individual liberty as a fundamental reality, given by "Nature and Nature's God," which, in the ideal state, would be as universal as possible.

In On Liberty, John Stuart Mill sought to define the "...nature and limits of the power which can be legitimately exercised by society over the individual," and as such, he describes an inherent and continuous antagonism between liberty and authority and thus, the prevailing question becomes "how to make the fitting adjustment between individual independence and social control".[5]

England (and, following the Act of Union 1707, Great Britain), laid down the cornerstones of the concept of individual liberty.

In 1166 Henry II of England transformed English law by passing the Assize of Clarendon. The act, a forerunner to trial by jury, started the abolition of trial by combat and trial by ordeal.[19]

1187-1189 sees the publication of Tractatus de legibus et consuetudinibus regni Anglie which contains authoritative definitions of freedom and servitude:

Freedom is the natural faculty of doing what each person pleases to do according to his will, except what is prohibited to him of right or by force. Sevitude on the other hand may be said to be the contrary, as if any person contrary to freedom should be bound upon a covenant to do something, or not to do it.[20]

In 1215 Magna Carta was enacted, arguably becoming the cornerstone of liberty in first England, then Great Britain, and later the world.

In 1689 the Bill of Rights granted "freedom of speech in Parliament", which laid out some of the earliest civil rights.[23]

In 1859 an essay by the philosopher John Stuart Mill, entitled On Liberty, argued for toleration and individuality. "If any opinion is compelled to silence, that opinion may, for aught we can certainly know, be true. To deny this is to assume our own infallibility."[24][25]

In 1958 Two Concepts of Liberty, by Isaiah Berlin, identified "negative liberty" as an obstacle, as distinct from "positive liberty" which promotes self-mastery and the concepts of freedom.[26]

In 1948 British representatives attempted to but were prevented from adding a legal framework to the Universal Declaration of Human Rights. (It was not until 1976 that the International Covenant on Civil and Political Rights came into force, giving a legal status to most of the Declaration.)[27]

According to the 1776 United States Declaration of Independence, all men have a natural right to "life, liberty, and the pursuit of happiness". But this declaration of liberty was troubled from the outset by the presence of slavery. Slave owners argued that their liberty was paramount, since it involved property, their slaves, and that Blacks had no rights that any White man was obliged to recognize. The Supreme Court, in the Dred Scott decision, upheld this principle. It was not until 1866, following the Civil War, that the US Constitution was amended to extend these rights to persons of color, and not until 1920 that these rights were extended to women.[28]

By the later half of the 20th century, liberty was expanded further to prohibit government interference with personal choices. In the United States Supreme Court decision Griswold v. Connecticut, Justice William O. Douglas argued that liberties relating to personal relationships, such as marriage, have a unique primacy of place in the hierarchy of freedoms.[29] Jacob M. Appel has summarized this principle:

I am grateful that I have rights in the proverbial public square but, as a practical matter, my most cherished rights are those that I possess in my bedroom and hospital room and death chamber. Most people are far more concerned that they can control their own bodies than they are about petitioning Congress.[30]

In modern America, various competing ideologies have divergent views about how best to promote liberty. Liberals in the original sense of the word see equality as a necessary component of freedom. Progressives stress freedom from business monopoly as essential. Libertarians disagree, and see economic freedom as best. The Tea Party movement sees big government as the enemy of freedom.[31][32]

France supported the Americans in their revolt against English rule and, in 1789, overthrew their own monarchy, with the cry of "Libert, galit, fraternit". The bloodbath that followed, known as the reign of terror, soured many people on the idea of liberty. Edmund Burke, considered one of the fathers of conservatism, wrote "The French had shewn themselves the ablest architects of ruin that had hitherto existed in the world."[33]

According to the Concise Oxford Dictionary of Politics, liberalism is "the belief that it is the aim of politics to preserve individual rights and to maximize freedom of choice". But they point out that there is considerable discussion about how to achieve those goals. Every discussion of freedom depends on three key components: who is free, what they are free to do, and what forces restrict their freedom.[34] John Gray argues that the core belief of liberalism is toleration. Liberals allow others freedom to do what they want, in exchange for having the same freedom in return. This idea of freedom is personal rather than political.[35] William Safire points out that liberalism is attacked by both the Right and the Left: by the Right for defending such practices as abortion, homosexuality, and atheism, and by the Left for defending free enterprise and the rights of the individual over the collective.[36]

According to the Encyclopdia Britannica, Libertarians hold liberty as their primary political value.[37] Their approach to implementing liberty involves opposing any governmental coercion, aside from that which is necessary to prevent individuals from coercing each other.[38]

According to republican theorists of freedom, like the historian Quentin Skinner[39][40] or the philosopher Philip Pettit,[41] one's liberty should not be viewed as the absence of interference in one's actions, but as non-domination. According to this view, which originates in the Roman Digest, to be a liber homo, a free man, means not being subject to another's arbitrary will, that is to say, dominated by another. They also cite Machiavelli who asserted that you must be a member of a free self-governing civil association, a republic, if you are to enjoy individual liberty.[42]

The predominance of this view of liberty among parliamentarians during the English Civil War resulted in the creation of the liberal concept of freedom as non-interference in Thomas Hobbes' Leviathan.[citation needed]

Socialists view freedom as a concrete situation as opposed to a purely abstract ideal. Freedom is a state of being where individuals have agency to pursue their creative interests unhindered by coercive social relationships, specifically those they are forced to engage in as a requisite for survival under a given social system. Freedom thus requires both the material economic conditions that make freedom possible alongside social relationships and institutions conducive to freedom.[43]

The socialist conception of freedom is closely related to the socialist view of creativity and individuality. Influenced by Karl Marx's concept of alienated labor, socialists understand freedom to be the ability for an individual to engage in creative work in the absence of alienation, where "alienated labor" refers to work people are forced to perform and un-alienated work refers to individuals pursuing their own creative interests.[44]

For Karl Marx, meaningful freedom is only attainable in a communist society characterized by superabundance and free access. Such a social arrangement would eliminate the need for alienated labor and enable individuals to pursue their own creative interests, leaving them to develop and maximize their full potentialities. This goes alongside Marx's emphasis on the ability of socialism and communism progressively reducing the average length of the workday to expand the "realm of freedom", or discretionary free time, for each person.[45][46] Marx's notion of communist society and human freedom is thus radically individualistic.[47]

Some authors have suggested that a virtuous culture must exist as a prerequisite for liberty. Benjamin Franklin stated that "only a virtuous people are capable of freedom. As nations become corrupt and vicious, they have more need of masters."[48] Madison likewise declared: "To suppose that any form of government will secure liberty or happiness without any virtue in the people, is a chimerical idea."[49] John Adams acknowledged: "Our constitution was made only for a moral and religious people. It is wholly inadequate to the government of any other."[50]

This also is remarkable in India, that all Indians are free, and no Indian at all is a slave. In this the Indians agree with the Lacedaemonians. Yet the Lacedaemonians have Helots for slaves, who perform the duties of slaves; but the Indians have no slaves at all, much less is any Indian a slave.

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Liberty - Wikipedia

Liberty City (Miami) – Wikipedia

Once a part of the sparsely populated outskirts of northern Miami, what became Liberty City developed during the Great Depression of the 1930s when President Franklin D. Roosevelt authorized the construction of the Liberty Square housing project in 1933, the first of its kind in the Southern United States. Built as a response to the deteriorating housing conditions in densely populated and covenant-restricted slums of Overtown, construction on the initial housing project began in 1934 and opened in 1937.

Into the 1940s and 1950s, the growing Liberty City and adjacent Brownsville thrived as a middle income black American community, hosting several churches, hospitals, and community centers. The area served as home to prominent figures such as Kelsey Pharr, M. Athalie Range (the first black American elected to serve on the Miami city commission) and boxer Muhammad Ali. Although segregation laws prohibited black Americans from resting and residing in popular Miami Beach, service establishment and resorts such as the Hampton House Motel and Villas catered to and entertained the likes of notables such as Rev. Dr. Martin Luther King, Jr., Althea Gibson, and even whites such as Mickey Mantle.

Construction of Interstate 95 in Florida in Overtown and declining use of restrictive covenants in the wake of the Civil Rights Act of 1964 dramatically altered the neighborhood into the 1960s. Increasing numbers of lower income elderly and welfare-dependent families migrated to the Liberty City neighborhood following their displacement primarily from inner city Overtown, leading to large-scale black flight of middle and higher income blacks and other blacks like West Indian Americans largely to suburban areas like Florida City and Miami Gardens in southern and northern Dade County, respectively.

Crime grew prevalent in the increasingly poverty-stricken area in the immediate post-Civil Rights Movement era of the 1960s and 1970s. The ensuing problems of the poor and disenfranchised grew most apparent and notable in race riots which occurred in Liberty City in August 1968 during the Republican National Convention in Miami Beach, and in 1980 following the acquittal of police officers charged with the killing of Arthur McDuffie.

The plight of inner-city black Miamians increasingly came to be highlighted in national press into the 1980s as the Hurricanes football team of the University of Miami won several national college football championships led by players recruited from the mostly black, lower income neighborhoods such as Liberty City and Overtown. National exposure continued with the popularity of nationally broadcast programs such as the NBC crime drama Miami Vice, which brought the deteriorating conditions of the area to greater prominence.

Into the 1990s and 2000s, the music grew to reflect the area with locals such as Luther Campbell of 2 Live Crew pioneering the Miami bass genre which dominated Southern hip hop music during the decade. Other music and sports talents rose to national prominence from the area such as rappers Trina and Trick Daddy and NFL players Chad "Ocho Cinco" Johnson, and Willis McGahee.

In 2000, Liberty City had a population of 23,009[3] and 43,054[4] residents, with 7,772 households, and 5,428 families residing in the neighborhood. The median household income was $18,809.87. The racial makeup of the neighborhood was 94.69% Black, 3.04% Hispanic or Latino of any nationality, 1.68% Other races (non-Hispanic), and 0.59% White.[3]

The zip codes for the Liberty City include 33127, 33142, 33147, and 33150. The area covers 5.968 square miles (15.46km2). In 2000, there were 19,286 males and 23,768 females. The median age for males was 25.9 years, while the median age for females was 30.3 years. The average household size had 3.1 people, while the average family size had 3.7 members. The percentage of married-couple families (among all households) was 20.3%, while the percentage of married-couple families with children (among all households) was 9.1%, and the percentage of single-mother households (among all households) was 33.1%. The percentage of never-married males 15 years old and over was 21.9%, while the percentage of never-married females 15 years old and over was 29.7%.[4]

In 2000, 2.7% of the population spoke little to no English. The percentage of residents born in Florida was 74.5%, the percentage of people born in another U.S. state was 16.7%, and the percentage of native residents but born outside the U.S. was 0.8%, while the percentage of foreign born residents was 7.9%.[4]

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Ron Paul: False Flag Could Ignite War in Venezuela

Former presidential candidate Ron Paul says he is concerned that a false flag provocation could be used to ignite war in Venezuela.

The countrys ruling socialist leader Nicolas Maduro is still in power after an attempt by opposition leader Juan Guaido failed to kick-start a military uprising fizzled.

Now Paul says that those who want to see the country plunged into more violence could stage a catalyzing event.

The big danger is a hard war breaking out, said the former Texas Congressman. Id still bet it wont be too bad, with thousands of troops moving. But it could be a guerrilla war or something like that. If there is a false flag or some important official on either side gets killed, you cant tell what might happen.

His co-host Daniel McAdams went further, suggesting that the deep state could assassinate Guaido.

He has been a kind of a hapless figure so far, said McAdams. He calls for mass protests and no one shows up. I dont think he realizes right now that he is actually now worth more dead than alive not only to the CIA, but also to his own opposition people. A shot in the crowd or something like that to take Guaido out. It might shock you, Dr. Paul, but the CIA is pretty good at this kind of things.

As we highlighted earlier this week, a government vehicle was caught mowing down a crowd of anti-Maduro, one of whom was reportedly killed.

Please support my work by getting one of the best energy drinks on the market without your support we cease to exist.

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Ron Paul: False Flag Could Ignite War in Venezuela

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AMD Posts Transitional First Quarter Ahead of Rome Launch

On the eve of its 50th anniversary, Advanced Micro Devices (AMD) reported sales of $1.27 billion for Q1 2019, down 10 percent quarter-over-quarter and 23 percent year-over-year. Despite the drop, revenue came in above Wall Streets expectations, and AMD is continuing its push to win back datacenter market share ceded to Intel over the last []

The post AMD Posts Transitional First Quarter Ahead of Rome Launch appeared first on HPCwire.

TAIPEI, Taiwan,May 2, 2019 Computer and server manufacturer Inventec Enterprise Business Group (Inventec EBG) today announced the release of its P47G4 server solution, optimized for AMD deep learning technologies. The P47G4 server is one of four optimized server solutions and featuresa 2U, single-socketsystem equipped withAMD EPYC processors and up to four AMD Radeon Instinct []

The post Inventec Collaborates with AMD to Provide Deep Learning Solutions appeared first on HPCwire.

One reason China has a good chance of hitting its ambitious goal to reach exascale computing in 2020 is that the government is funding three separate architectural paths to attain that milestone.

China Fleshes Out Exascale Design for Tianhe-3 Supercomputer was written by Michael Feldman at .

Over at the IBM Blog, Rahil Garnaviwrites that IBM researchers have developed new techniques in deep learning that could help unlock earlier glaucoma detection."Earlier detection of glaucoma is critical to slowing its progression in individuals and its rise across our global population. Using deep learning to uncover valuable information in non-invasive, standard retina imaging could lay the groundwork for new and much more rapid glaucoma testing."

The post IBM Research Applies Deep Learning for Detecting Glaucoma appeared first on insideHPC.

Researchers at the University of Pittsburgh are using XSEDE supercomputing resources to develop new materials that can capture carbon dioxide and turn it into a commercially useful substances. With global climate change resulting from increasing levels of carbon dioxide in the Earth's atmosphere, the work could lead to a lasting impact on our environment. "The basic idea here is that we are looking to improve the overall energetics of CO2 capture and conversion to some useful material, as opposed to putting it in the ground and just storing it someplace," saidKarl Johnson from the University of Pittsburgh. "But capture and conversion are typically different processes."

The post Pitt Researchers using HPC to turn CO2 into Useful Products appeared first on insideHPC.

Field Programmable Gate Arrays (FPGAs) have notched some noticeable wins as a platform for machine learning, Microsofts embrace of the technology in Azure being the most notable example.

FPGAs Open Gates in Machine Learning was written by Michael Feldman at .

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Supercomputer – Simple English Wikipedia, the free …

A supercomputer is a computer with great speed and memory. This kind of computer can do jobs faster than any other computer of its generation. They are usually thousands of times faster than ordinary personal computers made at that time. Supercomputers can do arithmetic jobs very fast, so they are used for weather forecasting, code-breaking, genetic analysis and other jobs that need many calculations. When new computers of all classes become more powerful, new ordinary computers are made with powers that only supercomputers had in the past, while new supercomputers continue to outclass them.

Electrical engineers make supercomputers that link many thousands of microprocessors.

Supercomputer types include: shared memory, distributed memory and array. Supercomputers with shared memory are developed by using a parallel computing and pipelining concept. Supercomputers with distributed memory consist of many (about 100~10000) nodes. CRAY series of CRAYRESERCH and VP 2400/40, NEC SX-3 of HUCIS are shared memory types. nCube 3, iPSC/860, AP 1000, NCR 3700, Paragon XP/S, CM-5 are distributed memory types.

An array type computer named ILIAC started working in 1972. Later, the CF-11, CM-2, and the Mas Par MP-2 (which is also an array type) were developed. Supercomputers that use a physically separated memory as one shared memory include the T3D, KSR1, and Tera Computer.

Organizations

Centers

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The Zeitgeist Movement – Skeptic Project

Author: Edward L WinstonAdded: June 13, 2010Discuss: Discuss this article.

Over the last couple of months, mainly since Zeitgeist Movement (TZM) members began trekking to our forums, I've gotten a lot of emails from TZM members asking me various questions. This post is to outline the topics covered in my correspondence with said members.

I'll likely update this page as I get feedback from people.

Primarily the issues discussed are why I believe TZM will fail and why I think it's impossible to find common ground with TZM. I want to be clear that, given a different set of circumstances which I will discuss, maybe TZM could be successful and we could find common ground, but if things don't change, neither will my stance.

The leader of TZM, Peter Joseph, is far more damaging to his own movement than I imagine many of the hardcore members want to believe:

More could be said about Peter Joseph, and is said in later sections, but our forums are full of former TZM members who shed even more light on the emerging cult of personality around him.

The most important issue here is that Peter Joseph is the leader of TZM and his word is law, despite claiming that he doesn't consider himself the leader, he acts unilaterally to forbid members for talking to outsiders, for example banning members who post on our forums that aren't glorifying him.

Something that I never stop hearing is the phrase the movies aren't the movement. This referring to the fact that the movies promote conspiracy theories, but TZM is something else entirely, and exists separately from the movement. I would believe that if not for the following issues:

A lot of people don't like that I use foul language, but I needed to display the utter lack of compassion for other human beings TZM leadership seems to have, as well as some hardcore members. The situation in Haiti, again, is a great example of this -- reading many posts on the forums from members, it's quite clear that unless The Venus Project (TVP) is going to be the solution to the problems in Haiti, there's no use in helping them after the earthquake there.

I get asked "well, what are YOU doing to improve the world?" by TZM members a lot. I constantly bring up that I volunteer pretty much every weekend and I donate 10% of my income to charity, and a lot of time I will donate more than that. Most come back with the fact "charity doesn't fix the problem." While they're right that charity doesn't fix the problem permanently, sitting on a forum doesn't either -- though some members have the audacity to claim that TZM is a charity, despite never lifting a finger for anyone else.

The example I use when talking to TZM members about this is:

If you saw a starving/dying man in the street, would you do something to help him, or would you say "once our movement gets to 50 million members, I'll be able to help you, but until then, see you later!"?

That's essentially the logic behind the leadership of TZM and what many members parrot to me, just in a much nicer way. They love talking about how many children are starving to death today, but they refuse to help them today, and instead speak of some far off future that they can't figure out how to get to.

I know and understand that not all TZM members are like this. I've seen some wonderful generosity and so forth coming from members, but more often than not, these members also don't follow Peter Joseph blindly, because the ones that do refuse to help anyone else.

Here's a list of problems that I believe TZM has:

There could be more added here later.

I don't really see a future for TZM outside of degrading to hardcore members. Peter Joseph talks about a new movie coming out in October of 2010 that's going to get "millions" of new members, so essentially nearly 2 years of doing nothing but waiting for yet another film are what TZM has to show for.

I think it's all a shame, however, because getting all of those people together could have done something, could have lead to actual success in some way, but it's not even close to that. This hasn't stopped members from discussing the transition to the Resource Based Economy, despite the fact they're discussing step 10,000 when they haven't even reached step 1 and don't seem to want to.

At this point is essentially a way to stroke Peter Joseph's ego rather than accomplish any goals.

Sometimes I'm asked what I'd change about TZM, in order to make it more acceptable. Well, while I don't think most of these changes are possible due to the way TZM is run, I usually humor those who ask:

So, essentially my "5 point plan" is completely incompatible with a movement where Peter Joseph is the overlord.

Would you like to know more?

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Human genetics | biology | Britannica.com

Human genetics, study of the inheritance of characteristics by children from parents. Inheritance in humans does not differ in any fundamental way from that in other organisms.

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genetics: Human genetics

Some geneticists specialize in the hereditary processes of human genetics. Most of the emphasis is on understanding and treating genetic

The study of human heredity occupies a central position in genetics. Much of this interest stems from a basic desire to know who humans are and why they are as they are. At a more practical level, an understanding of human heredity is of critical importance in the prediction, diagnosis, and treatment of diseases that have a genetic component. The quest to determine the genetic basis of human health has given rise to the field of medical genetics. In general, medicine has given focus and purpose to human genetics, so the terms medical genetics and human genetics are often considered synonymous.

A new era in cytogenetics, the field of investigation concerned with studies of the chromosomes, began in 1956 with the discovery by Jo Hin Tjio and Albert Levan that human somatic cells contain 23 pairs of chromosomes. Since that time the field has advanced with amazing rapidity and has demonstrated that human chromosome aberrations rank as major causes of fetal death and of tragic human diseases, many of which are accompanied by mental retardation. Since the chromosomes can be delineated only during mitosis, it is necessary to examine material in which there are many dividing cells. This can usually be accomplished by culturing cells from the blood or skin, since only the bone marrow cells (not readily sampled except during serious bone marrow disease such as leukemia) have sufficient mitoses in the absence of artificial culture. After growth, the cells are fixed on slides and then stained with a variety of DNA-specific stains that permit the delineation and identification of the chromosomes. The Denver system of chromosome classification, established in 1959, identified the chromosomes by their length and the position of the centromeres. Since then the method has been improved by the use of special staining techniques that impart unique light and dark bands to each chromosome. These bands permit the identification of chromosomal regions that are duplicated, missing, or transposed to other chromosomes.

Micrographs showing the karyotypes (i.e., the physical appearance of the chromosome) of a male and a female have been produced. In a typical micrograph the 46 human chromosomes (the diploid number) are arranged in homologous pairs, each consisting of one maternally derived and one paternally derived member. The chromosomes are all numbered except for the X and the Y chromosomes, which are the sex chromosomes. In humans, as in all mammals, the normal female has two X chromosomes and the normal male has one X chromosome and one Y chromosome. The female is thus the homogametic sex, as all her gametes normally have one X chromosome. The male is heterogametic, as he produces two types of gametesone type containing an X chromosome and the other containing a Y chromosome. There is good evidence that the Y chromosome in humans, unlike that in Drosophila, is necessary (but not sufficient) for maleness.

A human individual arises through the union of two cells, an egg from the mother and a sperm from the father. Human egg cells are barely visible to the naked eye. They are shed, usually one at a time, from the ovary into the oviducts (fallopian tubes), through which they pass into the uterus. Fertilization, the penetration of an egg by a sperm, occurs in the oviducts. This is the main event of sexual reproduction and determines the genetic constitution of the new individual.

Human sex determination is a genetic process that depends basically on the presence of the Y chromosome in the fertilized egg. This chromosome stimulates a change in the undifferentiated gonad into that of the male (a testicle). The gonadal action of the Y chromosome is mediated by a gene located near the centromere; this gene codes for the production of a cell surface molecule called the H-Y antigen. Further development of the anatomic structures, both internal and external, that are associated with maleness is controlled by hormones produced by the testicle. The sex of an individual can be thought of in three different contexts: chromosomal sex, gonadal sex, and anatomic sex. Discrepancies between these, especially the latter two, result in the development of individuals with ambiguous sex, often called hermaphrodites. The phenomenon of homosexuality is of uncertain cause and is unrelated to the above sex-determining factors. It is of interest that in the absence of a male gonad (testicle) the internal and external sex anatomy is always female, even in the absence of a female ovary. A female without ovaries will, of course, be infertile and will not experience any of the female developmental changes normally associated with puberty. Such a female will often have Turners syndrome.

If X-containing and Y-containing sperm are produced in equal numbers, then according to simple chance one would expect the sex ratio at conception (fertilization) to be half boys and half girls, or 1 : 1. Direct observation of sex ratios among newly fertilized human eggs is not yet feasible, and sex-ratio data are usually collected at the time of birth. In almost all human populations of newborns, there is a slight excess of males; about 106 boys are born for every100 girls. Throughout life, however, there is a slightly greater mortality of males; this slowly alters the sex ratio until, beyond the age of about 50 years, there is an excess of females. Studies indicate that male embryos suffer a relatively greater degree of prenatal mortality, so the sex ratio at conception might be expected to favour males even more than the 106 : 100 ratio observed at birth would suggest. Firm explanations for the apparent excess of male conceptions have not been established; it is possible that Y-containing sperm survive better within the female reproductive tract, or they may be a little more successful in reaching the egg in order to fertilize it. In any case, the sex differences are small, the statistical expectation for a boy (or girl) at any single birth still being close to one out of two.

During gestationthe period of nine months between fertilization and the birth of the infanta remarkable series of developmental changes occur. Through the process of mitosis, the total number of cells changes from 1 (the fertilized egg) to about 2 1011. In addition, these cells differentiate into hundreds of different types with specific functions (liver cells, nerve cells, muscle cells, etc.). A multitude of regulatory processes, both genetically and environmentally controlled, accomplish this differentiation. Elucidation of the exquisite timing of these processes remains one of the great challenges of human biology.

Immunity is the ability of an individual to recognize the self molecules that make up ones own body and to distinguish them from such nonself molecules as those found in infectious microorganisms and toxins. This process has a prominent genetic component. Knowledge of the genetic and molecular basis of the mammalian immune system has increased in parallel with the explosive advances made in somatic cell and molecular genetics.

There are two major components of the immune system, both originating from the same precursor stem cells. The bursa component provides B lymphocytes, a class of white blood cells that, when appropriately stimulated, differentiate into plasma cells. These latter cells produce circulating soluble proteins called antibodies or immunoglobulins. Antibodies are produced in response to substances called antigens, most of which are foreign proteins or polysaccharides. An antibody molecule can recognize a specific antigen, combine with it, and initiate its destruction. This so-called humoral immunity is accomplished through a complicated series of interactions with other molecules and cells; some of these interactions are mediated by another group of lymphocytes, the T lymphocytes, which are derived from the thymus gland. Once a B lymphocyte has been exposed to a specific antigen, it remembers the contact so that future exposure will cause an accelerated and magnified immune reaction. This is a manifestation of what has been called immunological memory.

The thymus component of the immune system centres on the thymus-derived T lymphocytes. In addition to regulating the B cells in producing humoral immunity, the T cells also directly attack cells that display foreign antigens. This process, called cellular immunity, is of great importance in protecting the body against a variety of viruses as well as cancer cells. Cellular immunity is also the chief cause of the rejection of organ transplants. The T lymphocytes provide a complex network consisting of a series of helper cells (which are antigen-specific), amplifier cells, suppressor cells, and cytotoxic (killer) cells, all of which are important in immune regulation.

One of the central problems in understanding the genetics of the immune system has been in explaining the genetic regulation of antibody production. Immunobiologists have demonstrated that the system can produce well over one million specific antibodies, each corresponding to a particular antigen. It would be difficult to envisage that each antibody is encoded by a separate gene; such an arrangement would require a disproportionate share of the entire human genome. Recombinant DNA analysis has illuminated the mechanisms by which a limited number of immunoglobulin genes can encode this vast number of antibodies.

Each antibody molecule consists of several different polypeptide chainsthe light chains (L) and the longer heavy chains (H). The latter determine to which of five different classes (IgM, IgG, IgA, IgD, or IgE) an immunoglobulin belongs. Both the L and H chains are unique among proteins in that they contain constant and variable parts. The constant parts have relatively identical amino acid sequences in any given antibody. The variable parts, on the other hand, have different amino acid sequences in each antibody molecule. It is the variable parts, then, that determine the specificity of the antibody.

Recombinant DNA studies of immunoglobulin genes in mice have revealed that the light-chain genes are encoded in four separate parts in germ-line DNA: a leader segment (L), a variable segment (V), a joining segment (J), and a constant segment (C). These segments are widely separated in the DNA of an embryonic cell, but in a mature B lymphocyte they are found in relative proximity (albeit separated by introns). The mouse has more than 200 light-chain variable region genes, only one of which will be incorporated into the proximal sequence that codes for the antibody production in a given B lymphocyte. Antibody diversity is greatly enhanced by this system, as the V and J segments rearrange and assort randomly in each B-lymphocyte precursor cell. The mechanisms by which this DNA rearrangement takes place are not clear, but transposons are undoubtedly involved. Similar combinatorial processes take place in the genes that code for the heavy chains; furthermore, both the light-chain and heavy-chain genes can undergo somatic mutations to create new antibody-coding sequences. The net effect of these combinatorial and mutational processes enables the coding of millions of specific antibody molecules from a limited number of genes. It should be stressed, however, that each B lymphocyte can produce only one antibody. It is the B lymphocyte population as a whole that produces the tremendous variety of antibodies in humans and other mammals.

Plasma cell tumours (myelomas) have made it possible to study individual antibodies, since these tumours, which are descendants of a single plasma cell, produce one antibody in abundance. Another method of obtaining large amounts of a specific antibody is by fusing a B lymphocyte with a rapidly growing cancer cell. The resultant hybrid cell, known as a hybridoma, multiplies rapidly in culture. Since the antibodies obtained from hybridomas are produced by clones derived from a single lymphocyte, they are called monoclonal antibodies.

As has been stated, cellular immunity is mediated by T lymphocytes that can recognize infected body cells, cancer cells, and the cells of a foreign transplant. The control of cellular immune reactions is provided by a linked group of genes, known as the major histocompatibility complex (MHC). These genes code for the major histocompatibility antigens, which are found on the surface of almost all nucleated somatic cells. The major histocompatibility antigens were first discovered on the leukocytes (white blood cells) and are therefore usually referred to as the HLA (human leukocyte group A) antigens.

The advent of the transplantation of human organs in the 1950s made the question of tissue compatibility between donor and recipient of vital importance, and it was in this context that the HLA antigens and the MHC were elucidated. Investigators found that the MHC resides on the short arm of chromosome 6, on four closely associated sites designated HLA-A, HLA-B, HLA-C, and HLA-D. Each locus is highly polymorphic; i.e., each is represented by a great many alleles within the human gene pool. These alleles, like those of the ABO blood group system, are expressed in codominant fashion. Because of the large number of alleles at each HLA locus, there is an extremely low probability of any two individuals (other than siblings) having identical HLA genotypes. (Since a person inherits one chromosome 6 from each parent, siblings have a 25 percent probability of having received the same paternal and maternal chromosomes 6 and thus of being HLA matched.)

Although HLA antigens are largely responsible for the rejection of organ transplants, it is obvious that the MHC did not evolve to prevent the transfer of organs from one person to another. Indeed, information obtained from the histocompatibility complex in the mouse (which is very similar in its genetic organization to that of the human) suggests that a primary function of the HLA antigens is to regulate the number of specific cytotoxic T killer cells, which have the ability to destroy virus-infected cells and cancer cells.

More is known about the genetics of the blood than about any other human tissue. One reason for this is that blood samples can be easily secured and subjected to biochemical analysis without harm or major discomfort to the person being tested. Perhaps a more cogent reason is that many chemical properties of human blood display relatively simple patterns of inheritance.

Certain chemical substances within the red blood cells (such as the ABO and MN substances noted above) may serve as antigens. When cells that contain specific antigens are introduced into the body of an experimental animal such as a rabbit, the animal responds by producing antibodies in its own blood.

In addition to the ABO and MN systems, geneticists have identified about 14 blood-type gene systems associated with other chromosomal locations. The best known of these is the Rh system. The Rh antigens are of particular importance in human medicine. Curiously, however, their existence was discovered in monkeys. When blood from the rhesus monkey (hence the designation Rh) is injected into rabbits, the rabbits produce so-called Rh antibodies that will agglutinate not only the red blood cells of the monkey but the cells of a large proportion of human beings as well. Some people (Rh-negative individuals), however, lack the Rh antigen; the proportion of such persons varies from one human population to another. Akin to data concerning the ABO system, the evidence for Rh genes indicates that only a single chromosome locus (called r) is involved and is located on chromosome 1. At least 35 Rh alleles are known for the r location; basically the Rh-negative condition is recessive.

A medical problem may arise when a woman who is Rh-negative carries a fetus that is Rh-positive. The first such child may have no difficulty, but later similar pregnancies may produce severely anemic newborn infants. Exposure to the red blood cells of the first Rh-positive fetus appears to immunize the Rh-negative mother, that is, she develops antibodies that may produce permanent (sometimes fatal) brain damage in any subsequent Rh-positive fetus. Damage arises from the scarcity of oxygen reaching the fetal brain because of the severe destruction of red blood cells. Measures are available for avoiding the severe effects of Rh incompatibility by transfusions to the fetus within the uterus; however, genetic counselling before conception is helpful so that the mother can receive Rh immunoglobulin immediately after her first and any subsequent pregnancies involving an Rh-positive fetus. This immunoglobulin effectively destroys the fetal red blood cells before the mothers immune system is stimulated. The mother thus avoids becoming actively immunized against the Rh antigen and will not produce antibodies that could attack the red blood cells of a future Rh-positive fetus.

Human serum, the fluid portion of the blood that remains after clotting, contains various proteins that have been shown to be under genetic control. Study of genetic influences has flourished since the development of precise methods for separating and identifying serum proteins. These move at different rates under the impetus of an electrical field (electrophoresis), as do proteins from many other sources (e.g., muscle or nerve). Since the composition of a protein is specified by the structure of its corresponding gene, biochemical studies based on electrophoresis permit direct study of tissue substances that are only a metabolic step or two away from the genes themselves.

Electrophoretic studies have revealed that at least one-third of the human serum proteins occur in variant forms. Many of the serum proteins are polymorphic, occurring as two or more variants with a frequency of not less than 1 percent each in a population. Patterns of polymorphic serum protein variants have been used to determine whether twins are identical (as in assessing compatibility for organ transplants) or whether two individuals are related (as in resolving paternity suits). Whether the different forms have a selective advantage is not generally known.

Much attention in the genetics of substances in the blood has been centred on serum proteins called haptoglobins, transferrins (which transport iron), and gamma globulins (a number of which are known to immunize against infectious diseases). Haptoglobins appear to relate to two common alleles at a single chromosome locus; the mode of inheritance of the other two seems more complicated, about 18 kinds of transferrins having been described. Like blood-cell antigen genes, serum-protein genes are distributed worldwide in the human population in a way that permits their use in tracing the origin and migration of different groups of people.

Hundreds of variants of hemoglobin have been identified by electrophoresis, but relatively few are frequent enough to be called polymorphisms. Of the polymorphisms, the alleles for sickle-cell and thalassemia hemoglobins produce serious disease in homozygotes, whereas others (hemoglobins C, D, and E) do not. The sickle-cell polymorphism confers a selective advantage on the heterozygote living in a malarial environment; the thalassemia polymorphism provides a similar advantage.

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Genetic Medicine : Division Home | Department of Medicine

Advances in molecular biology and human genetics, coupled with the completion of the Human Genome Project and the increasing power of quantitative genetics to identify disease susceptibility genes, are contributing to a revolution in the practice of medicine. In the 21st century, practicing physicians will focus more on defining genetically determined disease susceptibility in individual patients. This strategy will be used to prevent, modify, and treat a wide array of common disorders that have unique heritable risk factors such as hypertension, obesity, diabetes, arthrosclerosis, and cancer.

The Division of Genetic Medicine provides an academic environment enabling researchers to explore new relationships between disease susceptibility and human genetics. The Division of Genetic Medicine was established to host both research and clinical research programs focused on the genetic basis of health and disease. Equipped with state-of-the-art research tools and facilities, our faculty members are advancing knowledge of the common genetic determinants of cancer, congenital neuropathies, and heart disease. The Division faculty work jointly with the Vanderbilt-Ingram Cancer Center to support the Hereditary Cancer Clinic for treating patients and families who have an inherited predisposition to various malignancies.

Genetic differences in humans at the molecular level not only contribute to the disease process but also significantly impact an individuals ability to respond optimally to drug therapy. Vanderbilt is a pioneer in precisely identifying genetic differences between patients and making rational treatment decisions at the bedside.

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Genetic Medicine | List of High Impact Articles | PPts …

Genetic medicine is the integration and application of genomic technologies allows biomedical researchers and clinicians to collect data from large study population and to understand disease and genetic bases of drug response. It includes genome structure, functional genomics, epigenomics, genome scale population genomics, systems analysis, pharmacogenomics and proteomics. The Division of Genetic Medicine provides an academic environment enabling researchers to explore new relationships between disease susceptibility and human genetics. The Division of Genetic Medicine was established to host both research and clinical research programs focused on the genetic basis of health and disease. Equipped with state-of-the-art research tools and facilities, our faculty members are advancing knowledge of the common genetic determinants of cancer, congenital neuropathies, and heart disease.

Related Journals of Genetic Medicine

Cellular & Molecular Medicine, Translational Biomedicine, Biochemistry & Molecular Biology Journal, Cellular & Molecular Medicine, Electronic Journal of Biology, Molecular Enzymology and Drug Targets, Journal of Applied Genetics, Journal of Medical Genetics, Genetics in Medicine, Journal of Anti-Aging Medicine, Reproductive Medicine and Biology, Romanian journal of internal medicine

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The Migrant Crisis: What Does It Mean? – Life, Hope & Truth

Very rarely does a single image cut through the clutter of the media to both shock and touch the heart. The wrenching photograph of a drowned 3-year-old Syrian boy washed up on a Turkish beach was splashed across front pages of newspapers around the globe, riveting world attention on the massive and often tragic immigration crisis threatening to overwhelm Europe.

In a Europe already in trouble following the tumultuous Greek debt debacle, the migration crisis has eclipsed all other concerns. It risks spinning out of control as successive waves of migrants head there. Border mayhem, lack of common response and the inevitable questions of who will pay have member states of the EU squabbling to defend their own interests, seriously jeopardizing deeper European integration.

Nearly 400,000 detected migrants have poured into Europe this year, up from 216,000 during all of last year. Over 3,000 have died or are missing on the dangerous journey. Many more are on the way.

According to an Italian newspaper report, reprinted in the Feb. 18, 2015, Daily Mail in the U.K., ISIS planned to instigate a flood of 500,000 migrants into Europe as a form of psychological warfare. They also wanted to use the movement of peoples to bring several thousand of their followers into Europes communities.

Whether or not this report is accurate, the fear of ISIS entering Europe through the thousands of migrants is real.

What are the implications and potential repercussions of this spiraling immigration crisis? Will the face and future of Europe change due to the caravan of humanity headed north?

German Chancellor Angela Merkel, grappling with a humanitarian crisis whose scale and severity is unmatched since World War II, said, What we are experiencing now is something that will occupy and change our country in coming years. We want the change to be positive, and we believe we can accomplish that. Merkel believes the immigration crisis will define the next decade.

Europe is the closest safe, prosperous and accessible region to the Middle East and Africa. Some Middle Eastern countriessuch as Lebanon, Jordan and Turkeyhave taken in millions of refugees but are already overwhelmed and lack resources to take in more.

In stark contrast is the stance of wealthy Gulf countriesQatar, United Arab Emirates, Saudi Arabia, Kuwait, Oman and Bahrainwho have not offered resettlement places to their neighbors and cousins. (Saudi Arabia has, however, offered to build 200 mosques in Germany.)

The crisis now engulfing Europe began slowly in 2011 after the failed Arab Spring, when Tunisians risked their lives to cross the Mediterranean on rickety fishing trawlers to get to the Italian island of Lampedusa. The fall of the Gaddafi regime in Libya emboldened desperate sub-Saharan Africans to attempt the perilous passage from Libyan shores in far greater numbers.

As the Middle East disintegrated and border controls increased, a shift began. Migrants began to use comparatively cheaper and less risky Balkan routes through Turkey and Greece.

The spike in migrants this summer coincided with an obscure Twitter comment from a government agency in Nuremberg noting that the German government pledged to take all Syrian asylum applications, regardless of how they reached German territory.

Tributes to German Chancellor Angela Merkel sprang up in the Arab social media, calling her the loving mother and Mama Merkel. But the move breeched the existing EU protocol and, in essence, opened the doors to Germany. Smartphones, Facebook posts and media coverage of friends landing in Greece or getting off trains in Germany has inspired the migrant rush to Germany.

The most cherished benefit and cornerstone of European integration is enshrined in the Schengen Agreement of 1985, providing open internal borders and enabling people to move from one country to another without showing documents once inside the EU.

This has caused EU members on the MediterraneanGreece, Italy and (to a lesser extent) Spainand the transit countries of Serbia, Hungary and Slovenia to struggle as they attempt to control borders, register and fingerprint asylum seekers, as well as shelter and feed them.

The Syrian civil war has already devoured 250,000 people and displaced half the population, causing one in five Syrians (4 million people) to flee the blood-soaked country. Should the ruthless Assad regime fall to ISIS jihadists, then millions more Alawites and Christians would join the exodus.

While the overwhelming majority of migrants are Muslim, not all are refugees from Syria. Piggybacking on the crisis are migrants from other nations, stretching from Pakistan to North Africa. According to the United Nations, just 53 percent of the migrants are Syrian; The Daily Telegraph quotes figures as low as 40 percent.

The demographic distributionjust 15 percent children, 13 percent womenis telling. Rather than families fleeing persecution, the majority are young men fleeing war or poverty.

Four decades of war and Americas departure from Afghanistan and Iraq have led to more sectarian violence and revenge killings, driving many to Europes doorstep. An undercurrent of hopelessness in the teeming, disease-ridden, shanty megalopolises of Africa wracked with corrupt and tyrannical regimes is compounding the situation.

Hungarys minister for foreign affairs and trade Peter Szijjrt described the crisis bluntly in comments to the Hungarian Times. It is self-delusion to call this situation a migration crisis, warned Szijjrt. It is a massive migration of nations, with inexhaustible reserves. He predicted the crisis will continue for years and could see an astonishing 35 million migrants heading to Europe.

Other immigration policy experts see even greater numbers of refugees. According to Mark Krikorian, director of the Washington, D.C.based Center for Immigration Studies, There are hundreds of millions who would undertake the journeywhether jobs await them or notto ensure that their children grow up in Germany, France, England, or Sweden rather than Syria, Chad, Afghanistan, or Mali. What we are seeing is the vanguard of those millions calling Europes bluff (Where There Is No Border, the Nations Perish, National Review, Sept. 1, 2015).

Even more than other prosperous northern European economies such as Sweden and the U.K., the wealthy German colossus has become an enormous magnet for migrants. Registered asylum seekers in Germany are lodged and fed, provided medical care, have their children schooled or cared for, and are even entitled to pocket money.

As many as 800,000 are expected to apply for asylum in Germany this year, equal to 1 percent of Germanys population, and it is considering accepting another 500,000 annually for the next several years.

If Germany still had robust economic and demographic growth, it could absorb the influx. But it does not. While German unemployment appears low (4.7 percent), the economy is now growing at a paltry 1.6 percent annually. For the rest of Europe the ability to absorb a refugee influx is even worse.

For Germany, empathy and guilt for the countrys Nazi past are not the only incentives for the government (but not all Germans) to enthusiastically welcome an influx of foreigners fleeing violence in their homelands. Berlin needs replacement workers. Having the worlds lowest birthrate, Germany is shrinking rapidly. According to current demographic trends, it is due to shrink from a population of 81 million today to 68 million in coming decades.

What Germany is proposing, said syndicated columnist Rich Lowry, is undertaking a vast social and demographic experiment, with the rapid, bulk importation of Muslim immigrants into a country with an aging population (The Refugee Crisis Is Exposing Europes Folly, New York Post, Sept. 8, 2015).

With the number of Muslims in Europe increasing dramatically, Eastern and Central European countries are concerned. Their reluctance to take in Syrian refugees revolves around worries about integration of massive numbers of ethnically, culturally, religiously and linguistically different migrants. In August, the Slovak government said it would only accept Christians from Syria because in Slovakia we dont have mosques, according to an interior department spokesman.

Even beyond the menace of seeding ISIS-inspired terrorism, Hungarian Prime Minister Viktor Orbn warned of the threat to Europes Christian character because everything which is now taking place before our eyes threatens to have explosive consequences for the whole of Europe.

Dutch right-wing politician Geert Wilders called the immigrant surge an Islamic invasion, one that threatens our prosperity, our security, our culture and identity.

Former French President Nicolas Sarkozy focused on economic factors. He described as folly the idea of taking on dozens of thousands of migrants for whom we have no jobs in Europe. With an unemployment rate exceeding 10 percent, France already has had deep problems with the assimilation of Muslim migrants. A toxic brew of resentment is likely to form in countries such as Italy that already have staggering youth unemployment rates above 40 percent.

British Prime Minister David Cameron recently pledged another 100 million pounds ($152 million) in aid to assist the crisis, bringing Britains total contribution to 1 billion poundsits largest-ever response to a single humanitarian crisis. But the U.K. has resisted attempts from diplomats in Brussels to mandate a quota to redistribute to each EU member country the burden connected with resettling just 160,000 of the asylum seekers.

In July and August Mr. Cameron was faced with near daily media coverage of migrants chaotically storming vehicles at Frances English Channel port of Calais in attempts to enter Britain through the Eurotunnel. All this came as he was preparing to negotiate more favorable terms for the United Kingdom within the EU. The EU response will play a part in the results of an anticipated referendum in Britain by the end of 2017 on whether to stay in the union. The images from Calais and fears of Britain being swamped by new arrivalswith the EU to blamemake a Brexit, or British exit from the union, a stronger possibility.

Diplomats in Brussels have been at a loss on how to respond adequately to the situation. The United States spearheaded actions during previous humanitarian emergencies and Middle East crises, but the current lead from behind mantra in Washington has left a leadership void in the region.

Europe today, wrote professor of foreign affairs Walter Russell Mead, often doesnt seem to know where it is going, what Western civilization is for, or even whether or how it can or should be defended (The Roots of the Migration Crisis, The Wall Street Journal, Sept. 11, 2015).

As Europes frontiers have collapsed, the potential waves of immigration are so huge that European leaders are now contemplating alternatives other than fences and processing camps. Perhaps they will choose to deal more muscularly with the source of the problem rather than the aftermath.

Suddenly theres talk in Europe, wrote foreign affairs columnist Bret Stephens, about using military power to establish safe zones in Syria to contain the exodus of refugees.

Europe, even Germany, may have no choice, continued Stephens, except rebuilding its military and using hard power against unraveling neighbors (Farewell to the Era of No Fences, The Wall Street Journal, Sept. 7, 2015).

Thus the explosive refugee crisis may prove to be the opening round of a direct European involvement in the Middle East. The scene is being set for a biblical time of the end development involving the king of the South and the king of the North (Daniel 11:40).

As shocking as the tragic events unfolding in the Middle East and Europe areand what they portend for the futurethe Bible has a message of good news for those willing to watch therefore, and pray always, seeking to discern the signs of the times (Luke 21:36; Matthew 16:3).

You can learn more about the good news of a much better world free of violence and hopeless poverty in our free booklet Mystery of the Kingdom.

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The Migrant Crisis: What Does It Mean? - Life, Hope & Truth

Does God Exist? Proof 1: Origin of the Universe – Life …

When you look up into the night sky, you catch a glimpse of the same universe ancient stargazers saw. Even the few thousand stars visible to the naked eye can evoke awe and wonder (Psalm 8:3-4).

Now with the tools of modern astronomy, todays scientists see a universe undreamed of even a century ago. While the full extent of the universe remains unknown, astronomers have peered out multiple billions of light-years. Within this known universe, there may be as many as 10 sextillion stars (a 1 followed by 22 zeros).

The size of some of these stars is also mind-boggling. Our sun is huge from our perspectiveabout 109 times the diameter of the earth. Yet some stars may be more than 1,500 times that diameter! Such a large star, placed at the center of our solar system, would extend beyond the orbit of Jupiter.

The universe is far more amazing than the ancients could have imagined!

An explosion of knowledge began around a hundred years ago with the development of Albert Einsteins theory of general relativity concerning space, time and gravity. During the same period the construction of larger telescopes enabled astronomers to look deeper into space.

In 1929 Edwin Hubble used these tools to determine that the universe is not static but expanding. Further advances were spurred by new instrumentation, deep space probes and orbiting telescopes that can detect signals across the full spectrum of wavelengths.

This knowledge has led to the development of a generally accepted theoretical model for the beginning and growth of the universe. The model is referred to as the hot inflationary big bang theory or simply the big bang theory.

This theory is consistent with current observations and measurements of the observable universe; but as we will see, it doesnt really explain how the universe could have formed by entirely natural means. It requires us to accept certain premises outside the realm of the known laws of physics.

Can the origin of the universe be explained by purely physical means?

The other alternative is to accept that our awesome universe must have had a Creator and that this Creator must have had unimaginable power.

How can you know which alternative is true?

Many religious people believe in God, but have never proven His existence. When people are questioned about the reasons for their belief in God, typical responses are often more emotional than rational. Such responses include:

But God wants our belief in Him to be based on hard evidence, and He challenges us to do just that. Test all things, hold fast what is good (1 Thessalonians 5:21; see also Romans 1:20).

This article is the first in a series that will help you answer that challenge by examining some of the physical evidence for the existence of God. A good place to start is at the beginningthe origin of the universe. What is the evidence for God as the Creator of the universe?

The missing ingredient in the big bang theory is the power source.

The implications of the big bang theory are staggering. In order to believe it, though, we are asked to accept certain suppositions that fall outside the laws of nature and physics. These suppositions actually support the existence of an all-powerful Creator God.

First, the big bang theory and the scientific evidence behind it imply that space, time and the universe as a whole had a beginning. Anything having a beginning must have a cause. What was that first cause?

Second, the big bang theory is based on the premise that something (the entire universe) suddenly came into existence out of nothing. How could this happen?

Third, according to the big bang theory, at the beginning all the matter and energy in the entire universe was compressed into an infinitesimally small point of almost infinite temperature and density. Where did this seed come from, and what force held it together and then released it?

Fourth, another suppositioninflationwas introduced in order for the observable data to match the theory. The premise was that inflation occurred within the first trillionth of a second after the bang. This inflation caused the minuscule universe to increase in size to something perhaps approaching 50 percent of its current size! This idea defies all known laws of natural physics, but it does enable the theory to be consistent with the universe as we see it today.

The unanswered question is: What caused this sudden inflation to occur?

The big bang theory asks us to just accept these suppositions. Objections raised about these unanswered questions are typically dismissed by stating that there must be natural laws explaining it all, but they just have not been discovered yet. This response raises the question of who is exercising more faith in their beliefs. Scientists? Or those who believe in God as the Creator?

Scientists begin with a fundamental assumption that only natural processes and sequences of events that are consistent with natural laws should be considered. As such, the idea of God creating the universe is ruled out as a possibility from the beginning.

But then they present a theorythe hot inflationary big bang theorythat is not consistent with natural laws! The description of that first instant of inflation cant be explained by the laws of the universe.

God addresses this issue by pointing out that the physical evidence of creation proves that He is God. For since the creation of the world His invisible attributes are clearly seen, being understood by the things that are made, even His eternal power and Godhead, so that they are without excuse (Romans 1:20, emphasis added throughout).

The missing ingredient in the big bang theory is the power sourcea source beyond any natural physical lawa source beyond our imagination. The God of the Bible claims responsibility for the creation of the universe. Could anything other than the Almighty God fulfill the premises upon which the big bang theory is based?

The very first words of the Bible are, In the beginning God created the heavens and the earth (Genesis 1:1). But this scripture does not define how far back in time this beginning was. Scientific evidence suggests it was billions of years, and the Bible does not disagree. (See the Life, Hope & Truth article The Gap Theory for further explanation.)

A similar declaration of God as the Creator is found in other scriptures as well. For example, By the word of the Lord the heavens were made, and all the host of them by the breath of His mouth (Psalm 33:6). This scripture perhaps poetically suggests inflation and the expanding universe as a part of the creation, as does Isaiah 40:22: It is He who sits above the circle of the earth, and its inhabitants are like grasshoppers, who stretches out the heavens like a curtain, and spreads them out like a tent to dwell in.

Notice the emphasis on Gods power several verses later. To whom then will you liken Me, or to whom shall I be equal? says the Holy One. Lift up your eyes on high, and see who has created these things, who brings out their host by number; He calls them all by name, by the greatness of His might and the strength of His power; not one is missing (Isaiah 40:25-26).

This power to create is also emphasized in Revelation 4:11. You are worthy, O Lord, to receive glory and honor and power; for You created all things, and by Your will they exist and were created.

Science agrees with the Bible on the idea that time had a beginning. Paul, referring to Gods promise of eternal life, wrote: In hope of eternal life which God, who cannot lie, promised before time began (Titus 1:2).

This short article has merely scratched the surface of this huge subject. There is abundant physical evidence that the creation of the universe was a supernatural event. Scientists discoveries and theories point to a creation mechanism that cannot be explained by physical laws.

Only an all-powerful God could create something from nothing, constrain the energy of the universe in the palm of a hand, release this energy and inflate it in an instant to nearly the size of what we today call the universe.

The creation of this miraculous universe is only the first of many proofs of Gods existence. Next time we will explore a second proofthe design found in the universe. Could it have occurred without a Designer?

Learn more about creation as a proof of God in our Life, Hope & Truth articles Creation Demands a Creator, Does the Big Bang Theory Require a Miracle? and Is God Really the Creator?

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Does God Exist? Proof 1: Origin of the Universe - Life ...

Europe: Looking for a Savior? – Life, Hope & Truth

by Isaac Khalil - November 26, 2018

The European Union (EU) is desperate for strong leadership. Several pressures are mounting on the EU, and there is a growing sense in Europe that new leadership is needed to solve these problems and lead the European project forward.

Consider some of the crises and challenges that have threatened to tear the union apart over the last few years.

Germany is at the center of many of these issues and has been a driving force to keep the EU together through many of these crises. Many wonder what a post-Merkel Germany and Europe will look like.

After experiencing so many crises, it is not surprising that two-thirds of Europeans feel the world is getting worse. What does the Bible say about Europes future?

The book of Daniel records a dream God gave to King Nebuchadnezzar of Babylon that revealed an overview of a succession of world empires that would continue all the way to the return of Jesus Christ.

In the dream he saw a statue of a man composed of different metals: a head of gold, arms and chest of silver, belly and thighs of bronze, legs of iron, and feet of iron mixed with clay (Daniel 2:32-33). The prophet Daniel interpreted the dream for the king.

The book of Daniel, and history, identifies these kingdoms as follows:

To learn more details about this prophecy, read Daniel 2: Nebuchadnezzars Dream.

The Roman Empire collapsed in A.D. 476, but the interpretation of the dream of the prophetic statue revealed that there would be a revival of the Roman Empire during the time immediately before Christs return (Daniel 2:42-44).

Daniel 7 reveals Rome as a beast with ten horns (verse 7), representing 10 revivals of this empire throughout history (verses 20, 24). To date, nine revivalsall centered in Europehave come and gone.

We are now waiting for the 10th revival to arise in Europe. It will be one last attempt to unite the nations of Europe into a single force under one charismatic leader.

The European Union is likely the seed of a final revival of the Roman Empire.That brings us to today. The European Union is likely the seed of a final revival of the Roman Empire. It is very possible that this final revival will emerge out of the present EU or will be a system that emerges to replace it.

The Bible describes this final empire as iron mixed with ceramic clay that wont adhere to one another (Daniel 2:41-43). This perhaps indicates that the empire will be a composite of strong and weak nations that have a semblance of unity, but with underlying weaknesses and differences.

Unity has been the greatest hurdle for the European Union to solve as it has tried to form a superstate made up of multiple nations that speak multiple languages and have unique histories and different cultures.

The Bible reveals this hurdle will temporarily be resolved when a strong leader, referred to as the beast, will arise and make a united Europe the worlds dominant economic and military power. It is likely this leader will be charismatic and portray himself as a savior of Europe (much as Hitler and Mussolini portrayed themselves in the 1930s).

While bringing a temporary prosperity, security and peace, this final leader will eventually cause war and destruction on earth and even try to fight the returning Jesus Christ (Revelation 17:12-14).

Jesus Christ is the true Savior, who will save the world from itself. His Kingdom will end the failed empires of man and usher in world peace!

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Europe: Looking for a Savior? - Life, Hope & Truth

True Christianity: Imperfect People Striving Toward Perfection

That seems to be the prevailing opinion of the world when it comes to the Christian religionanachronistic fuddy-duddies who set the bar too high for everyone and then consistently fail to meet it themselves.

The data agrees. During a recent yearlong research effort in Scotland, the Barna Group found that the five phrases Scots were most likely to use in describing Christianity included judgmental, hypocritical and out of touch with reality.

And its not just Scotland. Those phrases are the stones slung at the Christian faith from all corners of the worldand I cant say as though I fault those doing the slinging. If you were to lump all those who call themselves Christian into the same category, it would be hard not to look at the results with disappointment.

Look no farther than the Bible itself, and youll find Jesus Christ expressing frustration over those who call Me Lord, Lord, and [do] not do the things which I say (Luke 6:46).

The lesson? Not everyone who takes on the mantle of Christianity is an actual Christian. In Scotland alone, seven out of 10 self-identified Christians are legacy Christiansthat is, Christians who do not believe basic elements of Christian doctrine or express personal faith in Jesus.

Thats a contradiction in terms. The word Christian implies a follower of Christ. A follower of Christ who doesnt follow Christ is a paradox, not a Christian. With ambassadors like that, its little wonder so much of the world casts such a disparaging eye on the entire religion.

But what about those who are genuinely seeking to follow Jesus Christ? Theyre not exactly perfect, either. But is it right to expect them to be? And do their personal failures discredit Christianity as a whole?

What, in other words, is a true Christian supposed to look like?

We could spend weeks on that subject and only begin to scratch the surface. A Christian is many different things all at once, but so much of it comes down to action. The apostle James warned that faith without works is dead (James 2:20) because, when it comes to believing in God, even the demons believeand tremble! (verse 19). Believing in God is one thing, but unless we couple that belief with action, there isnt much that distinguishes us from the demonic spirits who call Satan master. The demons believe in God, they even fear God, but they refuse to obey God.

A true Christian doesnt stop at believing in God. A true Christian repents, is baptized and receives Gods Spirit (Acts 2:38). A true Christian pursues a relationship with God, studying His Word and speaking with Him in prayer, seeking to know Him better and better each day (John 10:27).

A true Christian is in a continual state of self-examination (2 Corinthians 13:5), perpetually looking for ways to improve and grow. A true Christian is attentive to the will of God, striving to understand Gods commands and expectations and then live up to them, regardless of the personal cost or obstacles involved (1 John 5:3; Matthew 7:21).

A true Christian is all of these things, but not only these things. In fact, theres at least one major attribute of a true Christian I neglected to include in this list. Its an attribute I dont think most Christians talk about as much as we shouldmaybe because were embarrassed by it or ashamed of it. I can understand that. Its not a pretty aspect of following God; but its vital for us to understand it, talk about it andeven if we cant exactly be proud of itaccept it:

A true Christian is still flawed.

It comes with the territory. No one likes to advertise their imperfections, but accepting the teachings of the Son of God requires first admitting our own sinfulness. Jesus came preaching repentance as the first step of His gospel message (Mark 1:15). He also said, Those who are well have no need of a physician, but those who are sick. I did not come to call the righteous, but sinners, to repentance (Mark 2:17).

Becoming a Christian requires adopting Gods commandments as your own standardsstandards you know youll struggle to reach.

Becoming a Christian requires picking up the pages of Gods Word and saying, This is rightand then looking deep within your own heart and saying, Im not.

Becoming a Christian requires knowing that who you are is not who you want to beknowing that the final goal is always just ahead, that repentance and change and growth are processes requiring a lifetime of effort, not just a weekend.

Christians fail. Christians have shortcomings. Christians, from time to time, make terrible decisions and awful mistakes, because Christians arent Christ. They are flawed human beings trying to follow in the footsteps of a perfect God, and no one can do that without tripping from time to time.

In its most literal form, the Greek word for hypocrisy, hypokrisis, simply means acting. Theater productions in the time of Christ depended on the skill of the plays hypocrites, or actorsthe better the hypocrite, the more convincing the show. When Jesus accused religious leaders of hypocrisy, He was basically accusing them of being actorsplaying a certain character, putting on an entire performance for the sake of the audience, while in their hearts they were someone completely different. Their piety was a performance, not a genuine action.

God knows Hes called His people to do some hard things, and He doesnt expect them to make it through life without picking up some scratches and dings along the way.Two thousand years later, hypocrisy is a word we tend to throw around with a little less restraint. Rather than a word for clear cases of intentional deception, hypocrite is a label we apply to anyone who visibly fails to live up his or her own values.

Thats not always hypocrisy. Sometimes, thats just called humanity. All human beings have trouble living up to a set of standards that dont come naturallythe thing is, some of us just handle it differently.

When you encounter something thats broken, you can choose one of two responses. You can set about trying to find a solution, or you can convince yourself that the brokenness is an improvement and that it actually works better that way. Generally, the world tends to take the latter approachits easier and means nothing has to change besides some peoples opinions.

We live in a broken world filled with broken peoplebroken by our own sins, our own rejection of Gods perfect way of life. Every time it gets worse, the world seems to throw a party and say that the new brokenness is an improvement, the way it should have been from the beginning. Meanwhile, God is working with the broken people who are willing to admit that theyre brokenwho recognize that their brokenness needs to be fixed, not celebrated as the new normal.

And thats what a true Christian looks like: a faithful servant of God on a lifelong mission to work with God and repair whats broken and sinful in his or her own life. A Christians life isnt flawless or free of mistakes. Its not some shining alabaster monument to perfection; in fact, there are moments when its little more than an ugly, gritty mess in the process of being transformed through the power of the Holy Spirit into something special.

Looking for the church behind Life, Hope & Truth? See our Who We Are page.

God knows Hes called His people to do some hard things, and He doesnt expect them to make it through life without picking up some scratches and dings along the way.

As the apostle Paul was inspired to write, We are hard-pressed on every side, yet not crushed; we are perplexed, but not in despair; persecuted, but not forsaken; struck down, but not destroyedalways carrying about in the body the dying of the Lord Jesus, that the life of Jesus also may be manifested in our body. Therefore we do not lose heart. Even though our outward man is perishing, yet the inward man is being renewed day by day (2 Corinthians 4:8-10, 16).

In this life, were going to get pummeled. Were going to fail and make mistakes and fall short of Gods perfect standards, again and again and again. But a true Christian refuses to let the story end there. A true Christian knows that a righteous man may fall seven times and rise again (Proverbs 24:16, emphasis added).

Its not about how many times you fall down; its about how many times you get back up.

No matter how much abuse the outward man takes, the true Christians focus is on whats going on insidethat the genuineness of your faith, being much more precious than gold that perishes, though it is tested by fire, may be found to praise, honor, and glory at the revelation of Jesus Christ (1 Peter 1:7).

And that, in a nutshell, is what it means to be a Christian. Followers of Christ arent made perfect on day onerather, day one involves acknowledging perfection as the goal. Every day after is about pressing toward it.

For more information on going on to perfection (Hebrews 6:1), read our free booklet Change Your Life.

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True Christianity: Imperfect People Striving Toward Perfection

AltLeft.com "The Left of the AltRight"

Of all the mental shortcuts embedded in human languages which impede understanding of mindless processes (such as natural selection), few are more obnoxious than because. From this comes a tendency to anthropomorphise, and read all outcomes in nature as if they were ordained by something approximating an intention. Religion has to be an adaptation, because the religious (currently) outbreed the irreligious. The second clause in that sentence is (currently) correct, but the because makes it sound as though the current religious selection advantage represents some design feature with the desired (by what?) end of promoting reproductive fitness (adaptation). And fitness is where the matter rests. Contrast with the following sentence:

Under current conditions in which the religious outbreed the irreligious, religion is adaptive. This statement is of course tautologous, since to say that a trait or behaviour is adaptive means merely that under condition X it gives one a reproductive edge. The term adaptation, though, is often applied to traits or behaviours which are selectively neutral or even counter-adaptive in particular environments. Genes which contribute to an overzealous appetite may be fitness-neutral to a subsistence farmer but become obesogenic in the modern world of easily available food. The genes carrier still exercises this adaptation, but it is no longer adaptive, reproductively useful, except in an environment full of fat-fetishists.

Human society has changed so dramatically in the last two centuries that it would be hasty to say the least to assume that everything with a current selective disadvantage is an illness (due to pathogens, mutational load, or whatever). Just as equally, one cannot assume that something with a current advantage exists having evolved by resolving an adaptive problem. Religion was ubiquitous across cultures before the 20th century, yet now the religious fraction represent an ever tinier percentage of the population in many countries, and it remains to be seen just how tiny the genetic hard core of religiosity will get before the trend is reversed. If the presence of religion were explicable in terms of fitness benefit, why are the genes not already more widespread? This alone should be enough to tell you that genes (and thus, adaptation) per se had little to do with religions evolution.

But apparently this is not obvious to some. Many people are inclined to view adaptations as intricate mechanisms, which by dint of their intricacy are delicate and susceptible to dysfunction, rather like the springs and levers of a pocket-watch. All analogies are imperfect, but this is a useless one. Some traits, and indeed behaviours, are more prone to changing by exogenous insults than others. For instance, a particularly naive person might imagine that in a pandemic of severe endometriosis, whereby female beauty and youth cease to be predictive as indicators of fertility, males would be disincentivised from their sexual attraction to these traits because the attraction would no longer perform its original functions. Needless to say, this would not happen. Male callogamy (attention to beauty) has proven so reliably fitness-enhancing over the eons, since even before the human species, that it is extraordinarily resilient to any incentive change: selection will always favour a deterministic developmental pathway for such consistently valuable traits. General intelligence is yet another example: the current dysgenic trend is a product of the last few generations and on the order of ~1 point per generation despite ramping up of mutational load globally (well see how long it can last), and almost no non-genetic factors seem capable of depressing its expression to any appreciable degree. Lead looked plausible at some point, but then you remember that Victorians liked to use mercury in their make-up, and yet the 19th century was the most intellectually productive in human history.

Viewed under this light, the religion as adaptation thesis looks all the more dubious. Evolutionary forces selection, mutation, drift, etc are just as capable of acting on general intelligence and other psychological traits as anything else, hence the well-documented evolved changes in the European peoples since around AD1000: declines in violence, and probably gains in intelligence, culminating ultimately in the zenith of the 19th century. Evolution can indeed happen fast, but not that fast. The bulk of these changes took place over a period of, at minimum, 20 generations, not 2-3, and our intelligence has more or less survived the last 2-3 generations intact. Religion has not. It has none of the hallmarks of an adaptation, but all the hallmarks of a complex socially learned behaviour, maintained by powerful norm-enforcers and epistemic authorities, which has lost currency in recent decades for a variety of reasons, the most commonsense explanation being that it no longer appeals to the educated because the answers it gives are inferior to those of other epistemic authorities, i.e. scientists.

The human capacity for cultural transmission through language makes a nonsense of the notion that anything which is not adaptive, even across all environments, should be impossible to sustain. The most obvious example in Christian cultures is the vow of celibacy, and there are numerous others such as taboos against eating highly nutrient-dense foods, which persist among the undernourished tribes of Papua New Guinea. So too with the European wars of religion, which resulted in millions of young men dying childless in their haste to protect a non-existent natural resource, i.e. Gods favour.

Group selection is another temptation when formulating theories about the origin of religion the idea that even a behaviour which reduces fitness at the individual level can persist if it provides some advantage at the level of the social group. It is a neat idea, but clearly unworkable in practice. Suppose some cohort of ones country likes spreading the word of God through warfare call this behaviour X. They can seize new territory in Gods name and provide new land for others in their group who are not quite so zealous, and this may look like a success to the people who reap those rewards, but at the end of the day: the behaviour is still going to diminish because everyone who engages in it is at a massively elevated risk of dying before reproduction. Evolution does not care about states or dominions.

It is understandable why post hoc stories about religion as adaptation are popular, even among well-informed people. Intelligence is not a good predictor of having sensible views where political matters are concerned, since politics is about group loyalty more than anything else. This is why the number of US Democrats who thought immigration was an important social issue declined precipitously in the 2010s when it became the issue of the right; what mattered was showing solidarity against rival political coalitions (i.e. the right) rather than the truth. Adaptive stories about religion seem to appeal an awful lot to European traditionalist-nationalists who are hoping to use Christianity as the conduit for some kind of renewed ethnocentrism to uplift the European spirit. The Chinese do not seem to need it, oddly enough. Nor even the Czechs, much closer to home. It did not work for Rome, and it sure as fuck wont for us.

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Entheogens – PsychonautWiki

Entheogens ("generating the divine within")[2] are psychoactive substances used in a religious, shamanic, or spiritual context[3] that may be synthesized or obtained from natural sources. Jonathan Ott is credited with coining the term "entheogen".[4]

Entheogens have been used in a ritualized context for thousands of years and their religious significance is well established with anthropological and academic literature. Examples of traditional entheogens include psychedelics like peyote, psilocybin mushrooms, ayahuasca, and iboga; atypical hallucinogens like salvia and Amanita muscaria; quasi-psychedelics like cannabis; and deliriants like datura.

With the advent of organic chemistry, there now exist many synthetic drugs with similar psychoactive properties, many of which are derived from these plants. Many pure active compounds with psychoactive properties have been isolated from these respective organisms and synthesized chemically. These include the naturally occurring mescaline, psilocybin, DMT, salvinorin A, ibogaine, ergine, and muscimol, the semi-synthetic LSD, and synthetic substances (e.g., DPT used by the Temple of the True Inner Light and 2C-B used by the Sangoma).[5]

More broadly, the term entheogen is used to refer to any psychoactive substance used for its religious or spiritual effects, whether or not in a formal religious or traditional structure. This terminology is often chosen to contrast with the recreational use of the same substances. Studies such as the Marsh Chapel Experiment have documented reports of spiritual experiences from participants who were administered psychoactive substances in controlled trials.[6] Ongoing research is limited due to widespread drug prohibition; however, some countries have legislation that allows for traditional entheogen use.

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Entheogens - PsychonautWiki

gambling | Definition, History, Games, & Facts …

Gambling, the betting or staking of something of value, with consciousness of risk and hope of gain, on the outcome of a game, a contest, or an uncertain event whose result may be determined by chance or accident or have an unexpected result by reason of the bettors miscalculation.

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sports: Gambling and sports

One of the most popular forms of gambling is wagering on sports, which taps into the passion of sports fans. A bet placed on a race or a

The outcomes of gambling games may be determined by chance alone, as in the purely random activity of a tossed pair of dice or of the ball on a roulette wheel, or by physical skill, training, or prowess in athletic contests, or by a combination of strategy and chance. The rules by which gambling games are played sometimes serve to confuse the relationship between the components of the game, which depend on skill and chance, so that some players may be able to manipulate the game to serve their own interests. Thus, knowledge of the game is useful for playing poker or betting on horse racing but is of very little use for purchasing lottery tickets or playing slot machines.

A gambler may participate in the game itself while betting on its outcome (card games, craps), or he may be prevented from any active participation in an event in which he has a stake (professional athletics, lotteries). Some games are dull or nearly meaningless without the accompanying betting activity and are rarely played unless wagering occurs (coin tossing, poker, dice games, lotteries). In other games betting is not intrinsically part of the game, and the association is merely conventional and not necessary to the performance of the game itself (horse racing, football pools). Commercial establishments such as casinos and racetracks may organize gambling when a portion of the money wagered by patrons can be easily acquired by participation as a favoured party in the game, by rental of space, or by withdrawing a portion of the betting pool. Some activities of very large scale (horse racing, lotteries) usually require commercial and professional organizations to present and maintain them efficiently.

A rough estimate of the amount of money legally wagered annually in the world is about $10 trillion (illegal gambling may exceed even this figure). In terms of total turnover, lotteries are the leading form of gambling worldwide. State-licensed or state-operated lotteries expanded rapidly in Europe and the United States during the late 20th century and are widely distributed throughout most of the world. Organized football (soccer) pools can be found in nearly all European countries, several South American countries, Australia, and a few African and Asian countries. Most of these countries also offer either state-organized or state-licensed wagering on other sporting events.

Betting on horse racing is a leading form of gambling in English-speaking countries and in France. It also exists in many other countries. Wherever horse racing is popular, it has usually become a major business, with its own newspapers and other periodicals, extensive statistical services, self-styled experts who sell advice on how to bet, and sophisticated communication networks that furnish information to betting centres, bookmakers and their employees, and workers involved with the care and breeding of horses. The same is true, to a smaller extent, of dog racing. The emergence of satellite broadcasting technology has led to the creation of so-called off-track betting facilities, in which bettors watch live telecasts at locations away from the racetrack.

Casinos or gambling houses have existed at least since the 17th century. In the 20th century they became commonplace and assumed almost a uniform character throughout the world. In Europe and South America they are permitted at many or most holiday resorts but not always in cities. In the United States casinos were for many years legal only in Nevada and New Jersey and, by special license, in Puerto Rico, but most other states now allow casino gambling, and betting facilities operate clandestinely throughout the country, often through corruption of political authorities. Roulette is one of the principal gambling games in casinos throughout France and Monaco and is popular throughout the world. Craps is the principal dice game at most American casinos. Slot and video poker machines are a mainstay of casinos in the United States and Europe and also are found in thousands of private clubs, restaurants, and other establishments; they are also common in Australia. Among the card games played at casinos, baccarat, in its popular form chemin de fer, has remained a principal gambling game in Great Britain and in the continental casinos most often patronized by the English at Deauville, Biarritz, and the Riviera resorts. Faro, at one time the principal gambling game in the United States, has become obsolete. Blackjack is the principal card game in American casinos. The French card game trente et quarante (or rouge et noir) is played at Monte-Carlo and a few other continental casinos. Many other games may also be found in some casinosfor example, sic bo, fan-tan, and pai-gow poker in Asia and local games such as boule, banca francesa, and kalooki in Europe.

At the start of the 21st century, poker exploded in popularity, principally through the high visibility of poker tournaments broadcast on television and the proliferation of Internet playing venues. Another growing form of Internet gambling is the so-called betting exchangesInternet Web sites on which players make wagers with one another, with the Web site taking a small cut of each wager in exchange for organizing and handling the transaction.

In a wide sense of the word, stock markets may also be considered a form of gambling, albeit one in which skill and knowledge on the part of the bettors play a considerable part. This also goes for insurance; paying the premium on ones life insurance is, in effect, a bet that one will die within a specified time. If one wins (dies), the win is paid out to ones relatives, and if one loses (survives the specified time), the wager (premium) is kept by the insurance company, which acts as a bookmaker and sets the odds (payout ratios) according to actuarial data. These two forms of gambling are considered beneficial to society, the former acquiring venture capital and the latter spreading statistical risks.

Events or outcomes that are equally probable have an equal chance of occurring in each instance. In games of pure chance, each instance is a completely independent one; that is, each play has the same probability as each of the others of producing a given outcome. Probability statements apply in practice to a long series of events but not to individual ones. The law of large numbers is an expression of the fact that the ratios predicted by probability statements are increasingly accurate as the number of events increases, but the absolute number of outcomes of a particular type departs from expectation with increasing frequency as the number of repetitions increases. It is the ratios that are accurately predictable, not the individual events or precise totals.

The probability of a favourable outcome among all possibilities can be expressed: probability (p) equals the total number of favourable outcomes (f) divided by the total number of possibilities (t), or p = f/t. But this holds only in situations governed by chance alone. In a game of tossing two dice, for example, the total number of possible outcomes is 36 (each of six sides of one die combined with each of six sides of the other), and the number of ways to make, say, a seven is six (made by throwing 1 and 6, 2 and 5, 3 and 4, 4 and 3, 5 and 2, or 6 and 1); therefore, the probability of throwing a seven is 6/36, or 1/6.

In most gambling games it is customary to express the idea of probability in terms of odds against winning. This is simply the ratio of the unfavourable possibilities to the favourable ones. Because the probability of throwing a seven is 1/6, on average one throw in six would be favourable and five would not; the odds against throwing a seven are therefore 5 to 1. The probability of getting heads in a toss of a coin is 1/2; the odds are 1 to 1, called even. Care must be used in interpreting the phrase on average, which applies most accurately to a large number of cases and is not useful in individual instances. A common gamblers fallacy, called the doctrine of the maturity of the chances (or the Monte-Carlo fallacy), falsely assumes that each play in a game of chance is dependent on the others and that a series of outcomes of one sort should be balanced in the short run by the other possibilities. A number of systems have been invented by gamblers largely on the basis of this fallacy; casino operators are happy to encourage the use of such systems and to exploit any gamblers neglect of the strict rules of probability and independent plays. An interesting example of a game where each play is dependent on previous plays, however, is blackjack, where cards already dealt from the dealing shoe affect the composition of the remaining cards; for example, if all of the aces (worth 1 or 11 points) have been dealt, it is no longer possible to achieve a natural (a 21 with two cards). This fact forms the basis for some systems where it is possible to overcome the house advantage.

In some games an advantage may go to the dealer, the banker (the individual who collects and redistributes the stakes), or some other participant. Therefore, not all players have equal chances to win or equal payoffs. This inequality may be corrected by rotating the players among the positions in the game. Commercial gambling operators, however, usually make their profits by regularly occupying an advantaged position as the dealer, or they may charge money for the opportunity to play or subtract a proportion of money from the wagers on each play. In the dice game of crapswhich is among the major casino games offering the gambler the most favourable oddsthe casino returns to winners from 3/5 of 1 percent to 27 percent less than the fair odds, depending on the type of bet made. Depending on the bet, the house advantage (vigorish) for roulette in American casinos varies from about 5.26 to 7.89 percent, and in European casinos it varies from 1.35 to 2.7 percent. The house must always win in the long run. Some casinos also add rules that enhance their profits, especially rules that limit the amounts that may be staked under certain circumstances.

Many gambling games include elements of physical skill or strategy as well as of chance. The game of poker, like most other card games, is a mixture of chance and strategy that also involves a considerable amount of psychology. Betting on horse racing or athletic contests involves the assessment of a contestants physical capacity and the use of other evaluative skills. In order to ensure that chance is allowed to play a major role in determining the outcomes of such games, weights, handicaps, or other correctives may be introduced in certain cases to give the contestants approximately equal opportunities to win, and adjustments may be made in the payoffs so that the probabilities of success and the magnitudes of the payoffs are put in inverse proportion to each other. Pari-mutuel pools in horse-race betting, for example, reflect the chances of various horses to win as anticipated by the players. The individual payoffs are large for those bettors whose winning horses are backed by relatively few bettors and small if the winners are backed by a relatively large proportion of the bettors; the more popular the choice, the lower the individual payoff. The same holds true for betting with bookmakers on athletic contests (illegal in most of the United States but legal in England). Bookmakers ordinarily accept bets on the outcome of what is regarded as an uneven match by requiring the side more likely to win to score more than a simple majority of points; this procedure is known as setting a point spread. In a game of American or Canadian football, for example, the more highly regarded team would have to win by, say, more than 10 points to yield an even payoff to its backers.

Unhappily, these procedures for maintaining the influence of chance can be interfered with; cheating is possible and reasonably easy in most gambling games. Much of the stigma attached to gambling has resulted from the dishonesty of some of its promoters and players, and a large proportion of modern gambling legislation is written to control cheating. More laws have been oriented to efforts by governments to derive tax revenues from gambling than to control cheating, however.

Gambling is one of mankinds oldest activities, as evidenced by writings and equipment found in tombs and other places. It was regulated, which as a rule meant severely curtailed, in the laws of ancient China and Rome as well as in the Jewish Talmud and by Islam and Buddhism, and in ancient Egypt inveterate gamblers could be sentenced to forced labour in the quarries. The origin of gambling is considered to be divinatory: by casting marked sticks and other objects and interpreting the outcome, man sought knowledge of the future and the intentions of the gods. From this it was a very short step to betting on the outcome of the throws. The Bible contains many references to the casting of lots to divide property. One well-known instance is the casting of lots by Roman guards (which in all likelihood meant that they threw knucklebones) for the garment of Jesus during the Crucifixion. This is mentioned in all four of the Gospels and has been used for centuries as a warning example by antigambling crusaders. However, in ancient times casting lots was not considered to be gambling in the modern sense but instead was connected with inevitable destiny, or fate. Anthropologists have also pointed to the fact that gambling is more prevalent in societies where there is a widespread belief in gods and spirits whose benevolence may be sought. The casting of lots, not infrequently dice, has been used in many cultures to dispense justice and point out criminals at trialsin Sweden as late as 1803. The Greek word for justice, dike, comes from a word that means to throw, in the sense of throwing dice.

European history is riddled with edicts, decrees, and encyclicals banning and condemning gambling, which indirectly testify to its popularity in all strata of society. Organized gambling on a larger scale and sanctioned by governments and other authorities in order to raise money began in the 15th century with lotteriesand centuries earlier in China with keno. With the advent of legal gambling houses in the 17th century, mathematicians began to take a serious interest in games with randomizing equipment (such as dice and cards), out of which grew the field of probability theory.

Apart from forerunners in ancient Rome and Greece, organized sanctioned sports betting dates back to the late 18th century. About that time there began a gradual, albeit irregular, shift in the official attitude toward gambling, from considering it a sin to considering it a vice and a human weakness and, finally, to seeing it as a mostly harmless and even entertaining activity. Additionally, the Internet has made many forms of gambling accessible on an unheard-of scale. By the beginning of the 21st century, approximately four out of five people in Western nations gambled at least occasionally. The swelling number of gamblers in the 20th century highlighted the personal and social problem of pathological gambling, in which individuals are unable to control or limit their gambling. During the 1980s and 90s, pathological gambling was recognized by medical authorities in several countries as a cognitive disorder that afflicts slightly more than 1 percent of the population, and various treatment and therapy programs were developed to deal with the problem.

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gambling | Definition, History, Games, & Facts ...

Problem gambling – Wikipedia

urge to continuously gamble despite harmful negative consequences or a desire to stop

Problem gambling is an urge to gamble continuously despite harmful negative consequences or a desire to stop. Problem gambling is often defined by whether harm is experienced by the gambler or others, rather than by the gambler's behaviour. Severe problem gambling may be diagnosed as clinical pathological gambling if the gambler meets certain criteria. Pathological gambling is a common disorder that is associated with both social and family costs.

The DSM-5 has re-classified the condition as an addictive disorder, with sufferers exhibiting many similarities to those who have substance addictions.The term gambling addiction has long been used in the recovery movement.[1] Pathological gambling was long considered by the American Psychiatric Association to be an impulse control disorder rather than an addiction.[2] However, data suggest a closer relationship between pathological gambling and substance use disorders than exists between PG and obsessive-compulsive disorder, largely because the behaviors in problem gambling and most primary substance use disorders (i.e. those not resulting from a desire to "self-medicate" for another condition such as depression) seek to activate the brain's reward mechanisms while the behaviors characterizing obsessive-compulsive disorder are prompted by overactive and misplaced signals from the brain's fear mechanisms.[3]

Problem gambling is an addictive behavior with a high comorbidity with alcohol problems. A common feature shared by people who suffer from gambling addiction is impulsivity.

Research by governments in Australia led to a universal definition for that country which appears to be the only research-based definition not to use diagnostic criteria: "Problem gambling is characterized by many difficulties in limiting money and/or time spent on gambling which leads to adverse consequences for the gambler, others, or for the community."[8] The University of Maryland Medical Center defines pathological gambling as "being unable to resist impulses to gamble, which can lead to severe personal or social consequences".[9]

Most other definitions of problem gambling can usually be simplified to any gambling that causes harm to the gambler or someone else in any way; however, these definitions are usually coupled with descriptions of the type of harm or the use of diagnostic criteria.[citation needed] The DSM-V has since reclassified pathological gambling as "gambling disorder" and has listed the disorder under substance-related and addictive disorders rather than impulse-control disorders. This is due to the symptomatology of the disorder resembling an addiction not dissimilar to that of substance-abuse.[10] In order to be diagnosed, an individual must have at least four of the following symptoms in a 12-month period:[11]

A gambler who does not receive treatment for pathological gambling when in his or her desperation phase may contemplate suicide.[12] Problem gambling is often associated with increased suicidal ideation and attempts compared to the general population.[13][14]

Early onset of problem gambling increases the lifetime risk of suicide.[15] However, gambling-related suicide attempts are usually made by older people with problem gambling.[16] Both comorbid substance use[17][18] and comorbid mental disorders increase the risk of suicide in people with problem gambling.[16] A 2010 Australian hospital study found that 17% of suicidal patients admitted to the Alfred Hospital's emergency department were problem gamblers.[19] In the United States, a report by the National Council on Problem Gambling showed approximately one in five pathological gamblers attempt suicide. The council also said that suicide rates among pathological gamblers were higher than any other addictive disorder.[20]

According to the Illinois Institute for Addiction Recovery, evidence indicates that pathological gambling is an addiction similar to chemical addiction.[21] It has been observed that some pathological gamblers have lower levels of norepinephrine than normal gamblers.[22] According to a study conducted by Alec Roy, formerly at the National Institute on Alcohol Abuse and Alcoholism, norepinephrine is secreted under stress, arousal, or thrill, so pathological gamblers gamble to make up for their under-dosage.[23]

Studies have compared pathological gamblers to substance addicts, concluding that addicted gamblers display more physical symptoms during withdrawal.[24]

Deficiencies in serotonin might also contribute to compulsive behavior, including a gambling addiction. There are three important points discovered after these antidepressant studies:[25]

A limited study was presented at a conference in Berlin, suggesting opioid release differs in problem gamblers from the general population, but in a very different way from alcoholics or other substance abusers.[26]

The findings in one review indicated the sensitization theory is responsible.[27] Dopamine dysregulation syndrome has been observed in the aforementioned theory in people with regard to such activities as gambling.[28]

Some medical authors suggest that the biomedical model of problem gambling may be unhelpful because it focuses only on individuals. These authors point out that social factors may be a far more important determinant of gambling behaviour than brain chemicals and they suggest that a social model may be more useful in understanding the issue.[29] For example, an apparent increase in problem gambling in the UK may be better understood as a consequence of changes in legislation which came into force in 2007 and enabled casinos, bookmakers, and online betting sites to advertise on TV and radio for the first time and which eased restrictions on the opening of betting shops and online gambling sites.[30]

Pathological gambling is similar to many other impulse control disorders such as kleptomania.[31] According to evidence from both community- and clinic-based studies, individuals who are pathological gamblers are highly likely to exhibit other psychiatric problems concurrently, including substance use disorders, mood and anxiety disorders, or personality disorders.[32]

Pathological gambling shows several similarities with substance abuse. There is a partial overlap in diagnostic criteria; pathological gamblers are also likely to abuse alcohol and other drugs. The "telescoping phenomenon" reflects the rapid development from initial to problematic behavior in women compared with men. This phenomenon was initially described for alcoholism, but it has also been applied to pathological gambling. Also biological data provide a support for a relationship between pathological gambling and substance abuse.[25] A comprehensive UK Gambling Commission study from 2018 has also hinted at the link between gambling addiction and a reduction in physical activity, poor diet and overall well-being. The study links problem gambling to a myriad of issues affecting relationships, and social stability.[33]

Several psychological mechanisms are thought to be implicated in the development and maintenance of problem gambling.[34] First, reward processing seems to be less sensitive with problem gamblers. Second, some individuals use problem gambling as an escape from the problems in their lives (an example of negative reinforcement). Third, personality factors play a role, such as narcissism, risk-seeking, sensation-seeking and impulsivity. Fourth, problem gamblers suffer from a number of cognitive biases, including the illusion of control,[35] unrealistic optimism, overconfidence and the gambler's fallacy (the incorrect belief that a series of random events tends to self-correct so that the absolute frequencies of each of various outcomes balance each other out). Fifth, problem gamblers represent a chronic state of a behavioral spin process, a gambling spin, as described by the criminal spin theory.[36]

The most common instrument used to screen for "probable pathological gambling" behavior is the South Oaks Gambling Screen (SOGS) developed by Lesieur and Blume (1987) at the South Oaks Hospital in New York City.[37] In recent years the use of SOGS has declined due to a number of criticisms, including that it overestimates false positives (Battersby, Tolchard, Thomas & Esterman, 2002).

The DSM-IV diagnostic criteria presented as a checklist is an alternative to SOGS, it focuses on the psychological motivations underpinning problem gambling and was developed by the American Psychiatric Association. It consists of ten diagnostic criteria. One frequently used screening measure based upon the DSM-IV criteria is the National Opinion Research Center DSM Screen for Gambling Problems (NODS). The Canadian Problem Gambling Inventory (CPGI) and the Victorian Gambling Screen (VGS) are newer assessment measures. The Problem Gambling Severity Index, which focuses on the harms associated with problem gambling, is composed of nine items from the longer CPGI.[38] The VGS is also harm based and includes 15 items. The VGS has proven validity and reliability in population studies as well as Adolescents and clinic gamblers.

Most treatment for problem gambling involves counseling, step-based programs, self-help, peer-support, medication, or a combination of these. However, no one treatment is considered to be most efficacious and no medications have been approved for the treatment of pathological gambling by the U.S. Food and Drug Administration (FDA). Only one treatment facility[39] has been given a license to officially treat gambling as an addiction, and that was by the State of Virginia.[40] Gambling addiction in the United States is only getting worse, the National Helpline documented the calls they received from 2017 to 2018 and the results are surprising. In 2017 the average monthly call volume was 67,949 to increase to 68,683 calls per month in 2018. The National Helpline number is 1-800-662-HELP

Gamblers Anonymous (GA) is a commonly used treatment for gambling problems. Modeled after Alcoholics Anonymous, GA uses a 12-step model that emphasizes a mutual-support approach. There are three in-patient treatment centers in North America.[41] One form of counseling, cognitive behavioral therapy (CBT) has been shown to reduce symptoms and gambling-related urges. This type of therapy focuses on the identification of gambling-related thought processes, mood and cognitive distortions that increase one's vulnerability to out-of-control gambling. Additionally, CBT approaches frequently utilize skill-building techniques geared toward relapse prevention, assertiveness and gambling refusal, problem solving and reinforcement of gambling-inconsistent activities and interests.[42]

As to behavioral treatment, some recent research supports the use of both activity scheduling and desensitization in the treatment of gambling problems.[43] In general, behavior analytic research in this area is growing [44] There is evidence that the SSRI paroxetine is efficacious in the treatment of pathological gambling.[45] Additionally, for patients suffering from both pathological gambling and a comorbid bipolar spectrum condition, sustained release lithium has shown efficacy in a preliminary trial.[46] The opioid antagonist drug nalmefene has also been trialled quite successfully for the treatment of compulsive gambling.[47]

Other step-based programs are specific to gambling and generic to healing addiction, creating financial health, and improving mental wellness. Commercial alternatives that are designed for clinical intervention, using the best of health science and applied education practices, have been used as patient-centered tools for intervention since 2007. They include measured efficacy and resulting recovery metrics.[medical citation needed]

Motivational interviewing is one of the treatments of compulsive gambling. The motivational interviewing's basic goal is promoting readiness to change through thinking and resolving mixed feelings. Avoiding aggressive confrontation, argument, labeling, blaming, and direct persuasion, the interviewer supplies empathy and advice to compulsive gamblers who define their own goal. The focus is on promoting freedom of choice and encouraging confidence in the ability to change.[48]

A growing method of treatment is peer support. With the advancement of online gambling, many gamblers experiencing issues use various online peer-support groups to aid their recovery. This protects their anonymity while allowing them to attempt recovery on their own, often without having to disclose their issues to loved ones.[medical citation needed]

Research into self-help for problem gamblers has shown benefits.[49] A study by Wendy Slutske of the University of Missouri concluded one-third of pathological gamblers overcome it by natural recovery.[50]

One of the newest methods for treating problem gambling is the use of anti-addiction drugs. Trials of drugs used for heroin, opium and morphine addicts that reduce the production of dopamine, are currently being tested on gambling addicts. Dopamine is considered a key part of addiction and the hope is to develop a real-time antidote to help curtail the urge to gamble.

Gambling self-exclusion (voluntary exclusion) programs are available in the US, the UK, Canada, Australia, South Africa, France, and other countries. They seem to help some (but not all) problem gamblers to gamble less often.[51]

Some experts maintain that casinos in general arrange for self-exclusion programs as a public relations measure without actually helping many of those with problem gambling issues. A campaign of this type merely "deflects attention away from problematic products and industries," according to Natasha Dow Schull, a cultural anthropologist at New York University and author of the book Addiction by Design.[52]

There is also a question as to the effectiveness of such programs, which can be difficult to enforce.[53] In the province of Ontario, Canada, for example, the Self-Exclusion program operated by the government's Ontario Lottery and Gaming Corporation (OLG) is not effective, according to investigation conducted by the television series, revealed in late 2017. "Gambling addicts ... said that while on the ... self-exclusion list, they entered OLG properties on a regular basis" in spite of the facial recognition technology in place at the casinos, according to the Canadian Broadcasting Corporation. As well, a CBC journalist who tested the system found that he was able to enter Ontario casinos and gamble on four distinct occasions, in spite of having been registered and photographed for the self-exclusion program. An OLG spokesman provided this response when questioned by the CBC: "We provide supports to self-excluders by training our staff, by providing disincentives, by providing facial recognition, by providing our security officers to look for players. No one element is going to be foolproof because it is not designed to be foolproof".[52]

According to the Productivity Commission's 2010 final report into gambling, the social cost of problem gambling is close to 4.7 billion dollars a year. Some of the harms resulting from problem gambling include depression, suicide, lower work productivity, job loss, relationship breakdown, crime and bankruptcy.[54] A survey conducted in 2008 found that the most common motivation for fraud was problem gambling, with each incident averaging a loss of $1.1 million.[54] According to Darren R. Christensen. Nicki A. Dowling, Alun C. Jackson and Shane A.Thomas a survey done from 1994-2008 in Tasmania gave results that gambling participation rates have risen rather than fallen over this period.[55]

In Europe, the rate of problem gambling is typically 0.5 to 3 percent.[56] The "British Gambling Prevalence Survey 2007", conducted by the United Kingdom Gambling Commission, found approximately 0.6 percent of the adult population had problem gambling issuesthe same percentage as in 1999.[57] The highest prevalence of problem gambling was found among those who participated in spread betting (14.7%), fixed odds betting terminals (11.2%) and betting exchanges (9.8%).[57] In Norway, a December 2007 study showed the amount of present problem gamblers was 0.7 percent.[58]

In the United States, the percentage of pathological gamblers was 0.6 percent, and the percentage of problem gamblers was 2.3 percent in 2008.[59] Studies commissioned by the National Gambling Impact Study Commission Act has shown the prevalence rate ranges from 0.1 percent to 0.6 percent.[60] Nevada has the highest percentage of pathological gambling; a 2002 report estimated 2.2 to 3.6 percent of Nevada residents over the age of 18 could be called problem gamblers. Also, 2.7 to 4.3 percent could be called probable pathological gamblers.[61]

According to a 1997 meta-analysis by Harvard Medical School's division on addictions, 1.1 percent of the adult population of the United States and Canada could be called pathological gamblers.[62] A 1996 study estimated 1.2 to 1.9 percent of adults in Canada were pathological.[63] In Ontario, a 2006 report showed 2.6 percent of residents experienced "moderate gambling problems" and 0.8 percent had "severe gambling problems".[64] In Quebec, an estimated 0.8 percent of the adult population were pathological gamblers in 2002.[65] Although most who gamble do so without harm, approximately 6 million American adults are addicted to gambling.[66]

Signs of a gambling problem include:[medical citation needed]

Both casinos and poker machines in pubs and clubs facilitate problem gambling in Australia. The building of new hotels and casinos has been described as "one of the most active construction markets in Australia"; for example, AUD$860 million was allocated to rebuild and expand the Star Complex in Sydney.[67]

A 2010 study, conducted in the Northern Territory by researchers from the Australian National University (ANU) and Southern Cross University (SCU), found that the proximity of a person's residence to a gambling venue is significant in terms of prevalence. Harmful gambling in the study was prevalent among those living within 100 metres of any gambling venue, and was over 50% higher than among those living ten kilometres from a venue. The study's data stated:

"Specifically, people who lived 100 metres from their favourite venue visited an estimated average of 3.4 times per month. This compared to an average of 2.8 times per month for people living one kilometre away, and 2.2 times per month for people living ten kilometres away".[68]

According to the Productivity Commission's 2016 report into gambling, 0.5% to 1% (80,000 to 160,000)[69] of the Australian adult population suffered with significant problems resulting from gambling. A further 1.4% to 2.1% (230 000 to 350 000) of the Australian adult population experienced moderate risks making them likely to be vulnerable to problem gambling.[70] Estimates show that problem gamblers account for an average of 41% of the total gaming machine spending.[70]

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Problem gambling - Wikipedia

Spiritual Enlightenment – The RuneScape Wiki

Quick guides provide a checklist of steps for completing a quest.

Spiritual Enlightenment is a part of the Tales of the Arc miniquest series.

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[[File:Quest.png|21px|link=]] Quests:
  • [[Spiritual Enlightenment|Spiritual Enlightenment]]
    • [[Impressing the Locals|Impressing the Locals]]

nCompleted the "Meet the Assassin" voyage from Player-owned portnn*90 [[File:Slayer-icon.png|21x21px|link=Slayer|alt=Slayer]] [[Slayer]]"}

To begin, speak to The Assassin (Ling) on the island of Aminishi. She asks for help finding the monk, Yulong, but keeps her reasons secret. Ling suggests fighting the Acolytes of Seiryu on the northern portion of Aminishi to obtain clues.

Killing any monks of Aminishi will allow you to receive the three books. The books are The Path of the Monk, The Path of the Elemental, and The Path of the Dragon. The books have a 1/16, 1/32, and 1/64 chance of being dropped respectively. As you obtain the books, read them to progress in the miniquest. Be sure to save at least a few of the Spirit dragon charms you obtain, as you will need them later.

The three types of monk are the Sotapanna, Sakadagami, and Anagami. They require 90 Slayer to damage. All three types of monks are weak to Air spells.

Once all three books have been obtained and read, return to the southern shore and speak to Ling. You must speak to Ling before you can interact with Yulong. Then, with a few Spirit dragon charms in your inventory, head to the centre of the island, near the Sakadagami. Interact with the dragon statue to be sent to the Spirit Realm. A Spirit dragon charm is consumed per minute spent in the Spirit Realm. Run to the southern shore of the island (where Ling stood before) and speak to Yulong. Charms aren't consumed while you're talking to him. You must decide to either tell Ling where he is or agree to keep him hidden.

Once you finish speaking to Yulong, return to the statue and exit the Spirit Realm. Run back to the beach and speak to Ling. Depending on your earlier choice, you will either reveal Yulong's location or keep it a secret. Ling admits that Yulong was not a target for her to assassinate, but rather a childhood friend and ex-member of the Death Lotus assassin. Finish your conversation with Ling to complete the mini-quest.

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More here:

Spiritual Enlightenment - The RuneScape Wiki

The 3 Stages Of Spiritual Enlightenment – In5D

Spiritual enlightenment is the fundamental goal of most spiritual practices that you undertake. Enlightenment marks the culminating point of your practice you feel unity of soul with everything, all the mental and physical engagements are left aside. Spiritual enlightenment is the possession of highly evolved souls. Spiritual masters from all over over the world experience spiritual enlightenment, and help others on their own paths.

Spiritual enlightenment is often categorized into levels for practical purposes. The highest stage of spiritual enlightenment marks the attainment of unity with God or being one with everything. But can still there are certain levels through which the individual needs to evolve. In a similar way that man has evolved from more primitive animals, the human conciousiness or soul also evolves. For our practical purpose, put them in stages and analyze the state of being in each stage:

At the very first level of enlightenment, the individual starts experiencing reality as it is. It means that your mind ceases to interfere with what you are experiencing. We are engaged in continuous talk, gossip, analyzing the environment around us, planning about future, or worrying about the past. When you are in a state of spiritual enlightenment you are completely in the present moment. You stop judging and labeling the world. Your mind is calm, quite and still. You are very awake, and aware of the current moment right now.

At the second stage of enlightenment, you feel apart of yourself in everything around you. You feel a connection with every object and individual in the world. The borders between yourself and the world around you dissipate. Your soul begins to merge with Supreme Soul. You feel that you are not individual anymore and not separate from anything. You feel that you are in everything and everything is just a part of the Supreme Soul from where you also have emerged. Many people describe this feelings of completeness and love.

The third stage of enlightenment, you no longer feel connected to everything but realize you are everything. You the experience the oneness of Creator Source and are not separate from anything in the universe. This stage of enlightenment is a direct experience of oneness.

Spiritual enlightenment is the fruit that sets you free, as you lose all wants and wishes to receive the fruits of your actions. You feel the bliss of completeness and true love. At first it gives you the feeling that you need Light. At the next stage, you feel that you are merging in Light. And in the final stage you and the Light are one.

source: http://www.spiritualnow.com/articles/19/1/What-is-Spiritual-Enlightenment/Page1.html

Gregg Prescott, M.S.Editor, In5D.com

It is important to remember that when it comes to spiritual enlightenment, you cannot enlighten anyone else for this is a sole (and soul) journey. You can always help others along their path or even light the candle that piques their curiosity, but the only one you can truly enlighten is yourself. When it comes to enlightening others, all you can do is to plant the seed and hope the garden is watered with knowledge.

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Tags: enlightenment, spiritual, spiritual enlightenment

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The 3 Stages Of Spiritual Enlightenment - In5D

Andrew Yang Rejects Support From White Nationalists …

$1,000 a month or mainstream conservatism? It focuses the mind like a laser:

Theres no indication that the campaign has courted that support, and when reached by The Verge, Yang unequivocally rejected it. I denounce and disavow hatred, bigotry, racism, white nationalism, anti-Semitism and the alt-right in all its many forms. Full stop, Yang said in a statement. For anyone with this agenda, we do not want your support. We do not want your votes. You are not welcome in this campaign.

As one of the first Asian American candidates for President in our history and the son of immigrants, I see racism and white nationalism as a threat to the core ideals of what it means to be an American, Yang continued. I have two young children who will grow up in this country. I know what that means.

There are some people who are mad about this.

Im not one of those people. Why on earth would I be mad about this? The GOP Congress has condemned White Nationalists at least three times since Charlottesville. If memory serves, I believe they have done it last week and at least twice so far this year alone. Donald Trump even said after the shooting in Pittsburgh that those seeking the Jews destruction, we will seek their destruction.

Im under no illusions that Andrew Yang, an Asian Democrat running in a Democratic primary, is a White Nationalist or Alt-Right candidate. He is a Green Nationalist. He wants to give everyone $1,000 a month. Im on board with that. And let me tell you, Green Nationalism is sounding a whole lot more attractive right now than four more years of cuckservatism.

I voted for Donald Trump because of immigration, trade, foreign policy and political correctness. Ive watched him and graded him every day for over two years. He has failed across the board on all of those issues. He has also repeatedly shown that he is untrustworthy. What ever came of his promises to end birthright citizenship, social media censorship or Antifa violence? Does he not realize what a massive bait and switch it was to endorse RAISING legal immigration?

Now, I am thinking less about trying to reform the GOP and save America the last two years has shown that Republicans are utterly unwilling to so much as even try to amend their legislative agenda to make it more populist than what I can get out of the rotten system. Im now going to vote on the basis on issues like bills, health care, student loan debt and the costs of education. Thats what I want to hear about. Everyone has those concerns, not just White Nationalists.

I dont want to hear the 1,000th podcast about Robert Mueller or the 5,000th episode of Hannity about Peter Strzok. I dont want to read or listen to anymore copes about how Trump can still turn this around or wildly unrealistic 4D Chess scenarios about how Trump is going to do this or that at some point in the future. In 2020, I want candidates to explain to me in clear, unambiguous language what they can do to improve the material standard of living of White Americans.

The GOP isnt going to build the border wall. It isnt even going to deport the illegal aliens that are already here. It isnt going to do anything about cultural decay. It certainly isnt going to end abortion. None of the social issues that conservatives run on are real. The only thing that matters is rewarding donors with the policies they wanted like tax cuts, deregulation, criminal justice reform, etc. Cuckservatism has nothing going for it.

Im so over pretending that anyone in Republican politics or mainstream conservatism shares my values. Look around and you will find that the Trump entourage from top to bottom is nothing but uninspiring grifters with stale rhetoric: Charlie Kirk, Candace Owens, Diamond and Silk, Mike Huckabee, Seb Gorka, etc. If you watched CPAC and still believe that any of these types are going to somehow turn the country around, I got a 30 foot Mexican border wall to sell you!

When the GOP is running in 2020 on Democrats are the real anti-Semites and theyre gonna take away our cheeseburgers, literal Burger Nationalism which went from being a meme last year into their actual messaging, it is best to just step aside and take the Yang bucks.

Note: I dont even believe we will get those Yang bucks. I just think it is a better idea than anything that I saw at CPAC.

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Andrew Yang Rejects Support From White Nationalists ...