Money saver while globe-trotting the world TRAVEL UNION – Baltic Times

How to globe-trot and not lose on international banking transaction fees and exchange rates? TRAVEL UNION, a Lithuania-based company, has the answer. The Baltic Times Magazine met with RamanoKorneu, CEO of the company, to learn more.

What was the start of TRAVEL UNION?

Our project appeared in 2018 in response to the problems that currently exist in the travel industry when travellers use the services of classical banks and different loyalty programmes. Every year more and more people travel abroad (by 2020, there will be about 1.6 billion tourists in the world annually visiting foreign countries) and usually lose quite a lot of money on international transaction fees and exchange rates, not to mention awkward services. Moreover, many travellers rarely choosethe same travel agencies, stay in the same hotels, tend to use various flight options, resulting in millions of loyalty programme cards for hotels and airlines in their pocket or device. Quite often points earned by them just burn out before they can beused. Therefore, the decision, in which you have one card that allows you to pay everywhere without commissions, send money in different currencies and at the same time earn non-burning and widely-convertible travel loyalty points seemed very timely.

The real action started when the professionals in finance, tourism and IT gathered together. The combination of knowledge and experience gave birth to a great business model and product concept.

What do you believe makes your product particularly attractive?

Travel Union was planned not just as a mobile banking app for customers, but as a single ecosystem for travellers and travel partners. This model gives us the opportunity to offer our clients the lowest cost possible, the best travel offers in the market and at the same time to participate in our unified loyalty program #Time. Our loyalty program #Time is unique because the points are non-burning and can be converted into cash, great offers of our partners, and points of other loyalty programs - so it is a great incentive to use particularly our mobile banking app.

The main advantage of all our products, mobile banking, online banking for business - they are extremely convenient to use, money-saving and secure.

One of the key elements of our ecosystem is our own payment system, which will allow us to overcome the limitations of off-the shelf payment gateways(high sign-up costs and fees for every transaction, inability to customize and add new features, etc.)and which we will be able to offer as a product to our travel partners and other merchants.

Who is your average client?

Our mobile banking app is created for families with children, travellers, and busy people. They are tech-savvy and cost-conscious that is why they would rather choose a digital bank with a convenient and intuitive app offering basic services for free than a traditional bank.

Our remotely on-boarded kid's accounts and free payment cards with parental control will allow parents to teach their kids about money in an increasingly cashless society and will help in a family routine.In other words, we build the product according to our pain points and willingness to help other families, who usually experience the same problems raising kids.

From the corporate side our clients are companies of the travel industry: hotels, airlines, travel agencies, online marketplaces, excursion companies, duty free shops etc. In order to create a strong merchant network and ensure high processing volume we are going to offerthem all the benefits of a travel-specialised payment system.

Has the year 2019 been successful to TRAVEL UNION in terms of growth and what are you aiming at in 2020?

2019 was essential for the growth of our business we took a big step from the development of an innovative and unique concept and building a scalable technology-based business model towards a well-equipped and adequately-prepared business ventureready for launch.

Asfortechnologicalpartnership, in 2019 wesigned contracts with proven technology service providers offering high-tech solutions for fintech companies and created a well-tuned operating model.

In the beginning of 2020, the focus will be placed on pilot testing of the mobile application and on-line bank for legal entities to see how people use the product and make necessary adjustments.

The beginning of 2020 will also be marked by obtaining the Electronic Money Institution license in Lithuania and acquiring early customerstravel partners and travellers using a broad partners network. We aim toget as many as 50 thousand retail customers on board and over 100 of travel-related legal entities over the year. Weall see huge opportunities that we do not want to miss!

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Money saver while globe-trotting the world TRAVEL UNION - Baltic Times

Treehouses, Glass Igloos and Other Out-of-This-World Spots to Lay Your Head – The New York Times

Gone are the days when a hotel meant simply a bed, a desk and perhaps a minibar. A new wave of accommodations has bumped traditional lodging out of the way by offering unique experiences that are endlessly, irresistibly Instagrammable. Want to cozy up in a glass igloo to watch the Northern Lights? Or hang on for dear life from the side of a cliff in a transparent capsule? You can do all that these days for a price, of course.

Africa is dotted with luxurious safari lodges for guests who want to get as close as possible to the continents incredible animal life. But some get you closer than others. At Mfuwe Lodge in Zambia, 18 chalets are arranged around two large lagoons, creating the perfect setting for watching elephants as they visit in the late afternoons.

But Africa isnt the only continent to offer such close encounters of the animal kind. The Jungle Bubbles, at the Anantara Golden Triangle Elephant Camp & Resort in Bangkok, offers resort guests the chance to spend a night in a transparent bubble, witnessing elephants pass by.

But if you live in the United States, you dont have to travel far to get close to animal life. At the Farm Sanctuary in Watkins Glen, N.Y., guests can reserve one of a handful of tiny houses and mingle with some of the 800 farm animals rescued from abuse and mistreatment.

Mfuwe Lodge, from $400 per person; Jungle Bubbles, doubles from $567 plus resort costs; Farm Sanctuary, doubles from $275 per night.

Regardless of where you are in the world, theres a good chance you can stay in a treehouse-style accommodation. At Anavilhanas Jungle Lodge in the Amazon region of Brazil, guests can find themselves cocooned in the canopy of the Amazon, high above the Rio Negro river. Up in the tall trees of the pine forests of Northern Sweden, the Treehotel posits guests in mirrored cubes and cabins perched in the treetops, one of which is even shaped like a U.F.O.

On the edge of Kruger National Park in South Africa, the new &Beyond Ngala Treehouse opens this month, giving guests a chance to take a game drive out to the treehouse where they spend the night up high in the bush in a private tower. A different kind of treehouse greets guests in Costa Rica at Hotel Costa Verde, where a decommissioned airplane was reconstructed in the jungle canopy, so that guests actually sleep in a plane in the jungle canopy. But some travelers want to go even higher than the treetops. At Skylodge Adventure Suites in Peru, guests arrive either by hiking over 1,300 feet or 400 meters up, or by zipping in like a superhero on a series of zip lines. The rooms themselves are transparent capsules hanging on the side of a mountain with panoramic views of the Sacred Valley.

Anavilhanas Jungle Lodge, from $325 per person for a panoramic suite; Treehotel, doubles from $540; &Beyond Ngala Treehouse, from $695 per person; Hotel Costa Verde, doubles from $260; Skylodge Adventure Suites, from $467 per person with transport.

Not into heights? You can always go deep thanks to lodging options that offer an underwater experience. At Conrad Maldives Rangali Island, guests can reserve the Muraka, a two-level hotel room that includes an infinity pool and also reaches 16 feet below sea level. At The Manta Resort, off the coast of Pemba near Zanzibar, a butler boats out to meet guests on their private underwater island. And in Key Largo, Fla., travelers with scuba certifications can dive down for a stay at Jules Undersea Lodge.

Conrad Maldives Rangali Island, from $9,999; The Manta Resort, doubles from $1,900 per night with three night minimum; Jules Undersea Lodge, singles from $675.

A new group of hotels that have cropped up in some of the worlds coldest places provides travelers the chance to experience hygge, the Danish concept of cozy contentment. At Cielo Glamping Maritime in New Brunswick, Canada, guests can cuddle up inside domes nestled in the forest, with clear sides for views of the snowy sunsets. Want to see the Northern Lights but dont want to feel cold? Kakslauttanen Arctic Resort in Finland is designed for you. Featuring glass igloos (for lying in bed to watch the lights) and snow igloos (caves dug out of a snow bank), it's the perfect place for fancy snow bunnies.

If you find yourself in the middle of the Gobi desert, stay warm under a camel-hair blanket in a traditional Mongolian tent (called a ger) at the eco-lodge, the Three Camel Lodge.

Cielo Glamping Maritime, doubles from $311 for two nights, Kakslauttanen Arctic Resort, glass igloos from $566; Three Camel Lodge, tents with full board, activities, and transfer from $1,000 per person.

And if animals, treehouses or the cold really arent appealing, you can always settle for royalty. You may have heard of the famed Taj Mahal Palace in Mumbai, India, the landmark hotel that since 1903 has signified luxury tourism. But you might not know that in Jaipur, India, you can reserve a room in a palace once home to the citys maharajah, Sujn Rajmahal Palace. And for some British royalty vibes, check into The Newt in Somerset, where you can roam the grounds of the manors English gardens and sip tea in your castle. Or for Scandinavian style galore, try Nimb Hotel in Copenhagen, a 1909 castle with exteriors inspired by Moorish architecture.

Taj Mahal Palace, doubles from $314; Sujn Rajmahal Palace, doubles from $771; The Newt in Somerset, doubles from $343; Nimb Hotel, doubles from $440.

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Treehouses, Glass Igloos and Other Out-of-This-World Spots to Lay Your Head - The New York Times

Free training on Travel & Tourism industry launched online by Global Travel and Tourism Partnership – Travel Daily News International

The Global Travel and Tourism Partnership (GTTP), is making its popular introduction to the travel and tourism industry educational curriculum available for free at FutureLearn, the leading social learning platform. The Introduction to the Travel & Tourism Industry: Passport to the World course provides learners with an understanding of the sector and its many exciting career opportunities. Endorsed by the Institute of Travel & Tourism, the eight week course started on February 10, 2020.

On the Passport to the World course, students will explore key brands and trends in travel and tourism and have the opportunity to share experiences and ideas with each other. They will learn about the structure of the Travel & Tourism industry and how it operates. The course attendees will gain insights into where people travel, how they get there, and what they do when they arrive. They will also explore hotel and hospitality business strategy, food, and how to harness the power of social media when traveling or working abroad.

GTTP is a reputed nonprofit that aims, with the support of global companies, at encouraging students to build a profession in the Travel and Tourism industry, a sector that supports one in 10 jobs (319 million) worldwide and generates 10.4% of the global GDP (source: World Travel and Tourism Council). The current Global Partners are: Amadeus, American Express Global Business Travel, Carlson Family Foundation, CWT, dnata, KDS, Marriott International, Travelport, The Travel Corporation, and World Travel and Tourism Council. Their executives serve on GTTPs Advisory Board.

Michel Taride, Chairman of the GTTP Advisory Board, and highly respected travel industry veteran, remarked: The Passport to the World curriculum provides students with fascinating insights into the travel and tourism industry and introduces them to the plethora of meaningful career opportunities at every step in the customer journey. The course content is continually enriched with contributions from industry players to ensure that it is up to date and relevant for learners around the world.

Dr Attila Horvth, a renowned educator, GTTP Hungary Director, and one of the course trainers, added that: The course launch on FutureLearn follows a highly successful online pilot that had strong interest from its 1,000 participants from 110 countries. The Passport to the World is suitable for both private study to assist in career planning, as well as for use by teachers in the classroom and new joiners to the industry.

The course can be accessed for free from February 10, 2020 for 10 weeks. Learners can join the course after February 10th at any time within the 10 week live period. The course upgrade for just 62 (UK pounds sterling) provides a print and digital Certificate of Achievement upon successful completion along with anytime access to this course for as long as its on FutureLearn.

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Free training on Travel & Tourism industry launched online by Global Travel and Tourism Partnership - Travel Daily News International

Worldwide Car Rental Market Insights, 2019-2024 – Expected to Generate Revenues of $122.6 Billion in the Coming Years – Yahoo Finance

DUBLIN, Feb. 10, 2020 /PRNewswire/ -- The "Car Rental Market Research Report: By Vehicle Type, Channel, Purpose, Usage, Geographical Outlook - Global Industry Analysis and Forecast to 2024" report has been added to ResearchAndMarkets.com's offering.

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The World Travel and Tourism Council reported that in 2018, a growth of 3.9% was witnessed by the global travel and tourism industry. It created more than 319 million jobs worldwide and amassed $8.8 trillion in 2018. This massive growth in the industry also boosted the growth of other related industries, such as car rental.

Nowadays, tourists prefer renting cars to explore a new place as it gives them the flexibility of planning their own itinerary without the fear of relying on public transport system. Car rental services allow customers to travel to their choice of places as per their convenience.

Further, the rising disposable income has also established the trend of more people taking short trips. Rather than taking their own vehicle, customers prefer renting cars; airport rentals are the most common as tourists rent a car immediately after landing in a new country and keep the car with them for the whole duration of their stay or drop them off at convenient drop-off points.

Witnessing a 7.9% CAGR, the car rental market is expected to generate a revenue of $122.6 billion in the coming years.

Car rental services are offered via three different vehicle types: luxury, executive, and economy. During 2014-2018, the economy vehicle type was used the most for car rental services. These cars are inexpensive and are smaller in size and have a seating capacity of four to five persons. Being smaller in size, these cars have a high fuel efficiency, which makes them a suitable option for rental services.

Further, amidst growing environmental concerns, these cars are witnessing a high demand as their impact on the environment is not as severe as other cars. In the coming years, the luxury cars are predicted to register a faster growth in demand, as the global disposable income is improving. These cars offer superior performance, comfort, and have better configuration.

One of the key trends in the car rental market is the deployment of electric vehicles for rental purposes. In wake of rising concerns about vehicular emission, governments of many countries are bringing in stringent regulatory policies to cut down on such emissions. From offering subsidies and incentives to creating awareness about the harmful effects of conventional energy sources on the environment, governments and various organizations are working toward popularizing the use of electric vehicles.

In Europe and the U.S., one of the rental companies, Sixt SE offers fully electric cars in the luxury segment, such as BMW i8, BMW i3, tesla Model X, and Tesla Model S. In India, in 2018, Zoomcar India Pvt Ltd. entered into a partnership with Mahindra & Mahindra Ltd for the deployment of electric cars for rental purposes.

The popularity of the internet has resulted in the development of the online or digital car rental system, which is helping the car rental sector become more organized. Online car rental allows the consumers to shortlist the car of choice, and make bookings well in advance without the hassle of visiting the office.

Further, majority of the companies have their own applications, which can be used by consumers to avail any assistance that they may need throughout the rental period. Therefore, the digitization of the car rental process has made it much safer, transparent, and cost-effective, which has been instrumental in making these services popular.

Key Topics Covered

Story continues

Chapter 1. Research Background1.1 Research Objectives1.2 Market Definition1.3 Research Scope1.3.1 Market Segmentation by Vehicle Type1.3.2 Market Segmentation by Channel1.3.3 Market Segmentation by Purpose1.3.4 Market Segmentation by Usage1.3.5 Market Segmentation by Region1.3.6 Analysis Period1.3.7 Market Data Reporting Unit1.3.7.1 Value1.4 Key Stakeholders

Chapter 2. Research Methodology

Chapter 3. Executive Summary

Chapter 4. Introduction4.1 Definition of Market Segments4.1.1 By Vehicle Type4.1.1.1 Economy4.1.1.2 Executive4.1.1.3 Luxury4.1.2 By Channel4.1.2.1 Online4.1.2.2 Offline4.1.3 By Purpose4.1.3.1 Business4.1.3.2 Personal4.1.4 By Usage4.1.4.1 Local4.1.4.2 Airport4.1.4.3 Outstation4.2 Value Chain Analysis4.3 Market Dynamics4.3.1 Trends4.3.1.1 Deployment of Electric Vehicles in Car Rental Services4.3.1.2 Growing Number of Partnerships4.3.2 Drivers4.3.2.1 Rise in the Travel and Tourism Industry4.3.2.2 Availability of a Convenient Mobility Option4.3.2.3 Increasing Concern Towards the Environment4.3.2.4 Impact Analysis of Drivers on Market Forecast4.3.3 Restraints4.3.3.1 Consumers' Willingness to Own a Car4.3.3.2 Low Internet Penetration4.3.3.3 Lack of Transparency in Pricing System4.3.3.4 Impact Analysis of Restraints on Market Forecast4.3.4 Opportunities4.3.4.1 Digitization of Car Rental System4.3.4.2 Long Term Car Rental Services4.4 Porter's Five Forces Analysis

Chapter 5. Global Market Size and Forecast5.1 By Vehicle Type5.2 By Channel5.3 By Purpose5.4 By Usage5.5 By Region

Chapter 6. North America Market Size and Forecast

Chapter 7. Europe Market Size and Forecast

Chapter 8. APAC Market Size and Forecast

Chapter 9. RoW Market Size and Forecast

Chapter 10. User Analysis10.1 North America10.1.1 Car Rental User Analysis10.1.1.1 By Gender10.1.1.2 By Usage10.1.1.3 By Rental Length10.1.2 Customers' Motivation10.1.3 Customer Behavior and Trends10.2 Europe10.3 APAC

Chapter 11. Competitive Landscape11.1 Market Share Analysis of Key Players11.2 Benchmarking of Key Players11.3 Strategic Developments of Key Players11.3.1 New Service Launch11.3.2 Mergers and Acquisitions11.3.3 Partnership11.3.4 Service Expansions11.3.5 Geographic Expansion11.3.6 Other Developments

Chapter 12. Company Profiles12.1 ANI Technologies Pvt. Ltd.12.1.1 Business Overview12.1.2 Product and Service Offerings12.2 Uber Technologies Inc.12.3 Beijing Xiaoju Technology Co. Ltd. (Didi Chuxing)12.4 Addison Lee Ltd.12.5 Shenzhou Youche (Fujian) Information Technology Co. Ltd. (UCAR)12.6 Hertz Global Holdings Inc.12.7 Avis Budget Group Inc.12.8 Enterprise Holdings Inc.12.9 Europcar Mobility Group S.A.12.10 Sixt SE12.11 Car2Go Ltd.12.12 Localiza Rent a Car S.A.

For more information about this report visit https://www.researchandmarkets.com/r/lbkgc5

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Worldwide Car Rental Market Insights, 2019-2024 - Expected to Generate Revenues of $122.6 Billion in the Coming Years - Yahoo Finance

Atlantis, the Palm prepares for record-breaking year ahead – Breaking Travel News

Upon completion of a three-year makeover, Atlantis, the Palm has reported record-breaking 2019 with an average occupancy of 90 per cent.

This increase in visits is a result of strong footfall from top source markets, as well as from diversified markets, and is in line with the tourism strategy set out by Dubai Tourism.

Significantly bookings from the UAE were up by 39 per cent, while Norway experienced a 24 per cent growth in bookings, China an increase of 16 per cent and Russia 14 per cent.

Closer to home, bookings from Saudi Arabia surged by 25 per cent, while bookings from the rest of the resorts top markets, including the UK, USA and India, remained robust.

Ahead of Expo 2020 we undertook a programme that has updated our property with contemporary flair, while staying true to the propertys iconic heritage.

Revamped and revitalised, it has been stylishly upgraded, while still keeping the soul of Atlantis alive, said Timothy Kelly, managing director, Atlantis Resorts & Residences.

We are maintaining our focus on customer needs and demands, and constantly evolving, ensuring that each and every experience is unique, with all our visitors making memories that last a lifetime.

Dubai welcomed 16.73 million visitors in 2019, with Atlantis, the Palms diversified portfolio ensuring that more than half a million of these visitors checked into the iconic resort.

With Dubai Expo 2020 projected to attract 25 million visitors over a period of six months, more than 70 per cent of visitors will be coming from outside the UAE, which will have a significant effect on Dubais hospitality industry and Atlantis, the Palm is ready for the influx.

With Dubai attracting more than 16 million tourists in 2019, more than half a million of these opted to stay at or visit Atlantis, The Palm, which is testament to the hard work that has been put in to revitalise the resort.

We fully expect the year ahead to be a buoyant one and we are looking forward to welcoming even more tourists in 2020, said Kelly.

Last year was transformative for the Atlantis, the Palm.

The hotel saw the completion of the refurbishment programme that has refreshed the entire resort.

Following a vigorous competition, UAE based architects WA were selected to refurbish the resorts rooms and suites, delivering a contemporary underwater design to provide a fresh look and feel in keeping with the resorts underwater theme.

Integrated technology with sound bars and touch screen panels, oversized flat television screens and bespoke chandeliers are just some of the stand-out features of the spruced up new suites.

The programme has also seen the introduction of four new restaurants including the incredibly successful launch of revolutionary entertainment destination Wavehouse, the opening of the globally celebrated Cantonese fine dining restaurant Hakkasan and the introduction of Atlantis, the Palms poolside burger concept Beach Buns.

November also saw the introduction of the cutting-edge beachside venue White Beach & Restaurant, the new Dubai hotspot complete with a stylish infinity pool for laid-back lounging, with majestic, uninterrupted views of the glittering city skyline.

Additionally, all-day-dining restaurant Kaleidoscope received a complete refurbishment in 2018.

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Capping an excellent year for Atlantis, the Palm in 2019, the location was recognised as both the Worlds Leading Landmark Resort and Worlds Leading Hotel Dining & Entertainment Experience by voters at the World Travel Awards.

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Atlantis, the Palm prepares for record-breaking year ahead - Breaking Travel News

Mexico City Is Proposing to Build One of the World’s Largest Urban Parks – Smithsonian.com

Walking along the edge of a seasonally dry lakebed on the eastern outskirts of Mexico City, there is near perfect silence except for the occasional airplane that flies overhead.

These planes flying out of a nearby airport are a reminder of the estimated US$13 billion international airport that had been planned and partially constructed on top of the seasonal wetlands native to this place. Then, in 2018, Mexicos new president, Andrs Manuel Lpez Obrador, canceled the project and moved forward with plans to construct what would be one of the worlds largest urban parks instead. Experts from around the world hope the project, if successful, will serve as an example to other cities of what is possible in the fight against climate change.

The size of the proposed park is nearly unfathomable from ground level, covering 12,300 hectares (30,394 acres) and stretching 16 kilometers (10 miles) from end to end. Thats about the size of 36 New York Central Parks or more than twice the size of Manhattan.

The government and the architect behind the park, known as Parque Ecolgico Lago de Texcoco, see great potential in the park particularly in the face of mounting water shortages, floods and climate change. They view this mega project as one that could turn back the clock on disruptions to the regions water systems dating back to Hernn Corts and the Spanish siege of Tenochtitlan in 1521.

The regions lakes were the primary source of freshwater during Aztec times, but the Spanish drained the valleys lakes after they took over the city of Tenochtitlan. This forced an independent Mexico centuries later to construct hundreds of miles of pipes to bring in roughly 30 percent of the citys water and to pump the rest from an underground aquifer. The city is now pumping water out of that aquifer twice as fast as water is returning via rainfall.

On the other side of the equation, the city, which has been largely paved over, floods for months during the rainy season.

The problem is we cannot turn 500 years of history and go 180 degrees overnight, says Mexico City architect Iaki Echeverra, executive director of the park project. Very few times you are offered the possibility that can have an impact that can really change things. If we manage to do this, it changes the direction of the history of the city and the valley.

The project is designed to be constructed in the basin of the former Lake Texcoco, which dried as Mexico City expanded into a megacity of more than 20 million people over the past two millennia. The area has not been inhabited and has been off-limits to the public due to annual flooding and infrastructure issues.

Echeverra is seeking to restore the vast majority of the area to its former state, including rejuvenating numerous lakes that were drained, as well as wetland areas. One of the goals of the project is to merge the concepts of public spaces and green infrastructure, providing hiking trails, sports courts and lakes for recreation, while bringing back the lakes to rebalance the Valley of Mexicos water system. That includes routing stormwater runoff into the wetlands and replenishing aquifers.

This is really the only space thats left [in the city] and its federal land and its untapped, Echeverra says. It was going to disappear. Right now theres a possibility to keep it, so we are really working hard to make this happen as soon as possible, to bring people here to understand that this is not a fantasy. This is something that can happen.

The government hopes to open up the first section of the park project by 2021, according to Echeverra. The architect, who grew up in Mexico City, says he is feeling the pressure from all angles to complete the project or get each component on the right path before the end of the current presidential administration in 2024.

People are expecting me to fail. A lot of people. For the right reasons, for the wrong reasons, for every reason, Echevarra says. Theres a lot of people betting this will not happen, so of course theres pressure.

In addition to the water-system goals of the park, the project team is planning for a significant solar power component and is considering wind and biofuels to offset maintenance costs.

I cannot afford the luxury of just going crazy on the beauty of this place like I used to, Echeverra says, referring to his previous work designing projects; now, as the director of the entire project, he has to worry about more than just design, such as costs and implementation. I have to give it the means to maintain itself, he says. The means to grow, the means for it not to disappear after this government is gone.

Echeverra had proposed a design for the park 10 years ago, but that plan was quashed to make way for the airport project.

We thought it was dead for sure and it suddenly comes back to life again. Im not mystical or anything, but its almost like the lake is refusing to die completely, Echeverra says. Its fighting. I think we had to get involved in that fight.

The governments decision to dedicate an enormous plot of land for natural area and green infrastructure so near the city center is a progressive one that experts say could affect the future of public spaces around the world.

If this is successful, a lot of people will go there and learn from it, says Steffen Lehmann, director of the University of Nevada, Las Vegas, School of Architecture and co-director of the interdisciplinary Urban Futures Lab. Cities are learning from each other. Cities are learning that they should share their best practices.

Lehmann, an internationally recognized architect and author on sustainable architecture and urban design, pointed to New Yorks High Line project and the High Line-ization of copycat parks around the world as an example.

Other world cities that have completed major urban parks in recent years include Seoul, Moscow and Singapore.

Its going to have a huge impact, Lehmann says of the upcoming Mexico City project. We need urban forests with climate change, and we need those parks to keep cities cool because of the urban island effect. Cities heat up and store and trap solar radiation and store heat like an oven. Its underestimated. Its a big silent killer.

The project will also capture carbon and mitigate air pollution.

Lehmann says there is an ongoing struggle against the privatization and urbanization of public space in cities around the world.

This is the kind of work that cities are hungry for. They are looking for ways to include good local governance practices and good water management practices, says Raul Pacheco-Vega, a water scholar at Centro de Investigacin y Docencia Econmicas, a Mexico City-based think tank. Here you kill three birds with one stone. You improve urban governance by providing more green space, you improve water management, and you showcase measures of adaptation to climate change.

Echevarra is directing the project for the National Water Commission (Conagua), and has gathered a diverse team of ecologists, architects, planners, landscapers, biologists and politicians to bring the project to life.

The first phase, restoring Lake Nabor Carrillo and building public sporting facilities in a portion adjacent to it, is expected to break ground in early 2020. That portion will also include a 10-kilometer (6-mile) running trail around the lake.

Eventually, the project will expand to the area where the airport had been partially built and involve restoring the Casa Colorada lake, which will flood the already-built runway and terminal foundations.

Theres a lot of things that have to happen over there, Echevarra says, referring to an ongoing legal battle over the canceled airport. Ive tried to keep a very cold mind about that. We have so much work to do without even touching that area. We will work on that. From a project stance, we will begin working as soon as its legally permitted.

The project is located roughly 10 miles (16 kilometers) from the citys Centro Histrico and is directly adjacent to some of the poorest neighborhoods in Mexico City, according to Echevarra.

It would be something of a life-changing situation if this space could be created and be next to what is the highest rate of crime and highest rate of poverty in the entire metropolitan region, he says.

The project currently is being funded completely by public money, according to Echevarra; but he says his team is looking into private funders for portions of the site, including the renewable energy production areas.

Preliminary studies required for the project were estimated at US$11.78 million, according to Conagua.

I think if we manage to do this, it would set a precedent for change worldwide, Echevarra says. Its such a large opportunity to do the right thing. If we manage to do it, everybody would be interested in it. We have to.

This piece was originally published on Ensia, a nonprofit media outlet published by the Institute on the Environment at the University of Minnesota.

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Mexico City Is Proposing to Build One of the World's Largest Urban Parks - Smithsonian.com

Who will speak at the WTTC Summit in Cancun? – eTurboNews | Trends | Travel News

After moving the 20th Global Summit of the World Travel & Tourism Council [WTTC] from Puerto Rico to Cancun, Quintana Roo, the organization unveiled the participation of known leaders in the travel and tourism industry.

They include Chris Nassetta, President and CEO of Hilton; Alex Zozaya, President of Apple Leisure Group; Kim Day, CEO of Denver Airport and Richard Fain, President and CEO of Royal Caribbean Cruises.

The summit will take place from 22-23 April 2020, at the Moon Palace Convention Centre in Cancun, Mexico.

The following speakers are already confirmed. China appears not to have a role in the summit this time. Participation from the Gulf region appears to be weak. The Arabian Travel Market in Dubai is taking place at the same time from 22-25 April.

Over the next several weeks, WTTC will be celebrating its 30th anniversary while also preparing for the 20th Global Summit in Cancun. The theme forthis years Summit; Making a Lasting Difference, will encourage delegates to discuss approaching the world differently, recognizing that what has got us to this point, will not work to tackle global challenges and incite positive change for the future.

WTTC is focused on the ways that the world is changing, and how this will initiate a change in how we travel, and how the Travel & Tourism sector operates. Digital transformation and the emergence of new technologies such as 5G, combined with global challenges such as climate change and geopolitical and economic crises, will turn the world on its head once more. With such rapid, dramatic and interlinked changes, WTTC and its Members must be sure to stay ahead of the curve.

The world is on the edge of fascinating social change, driven by huge technological advances, with every generation having to adapt to this new world. WTTC will be part of that social change and, at the Summit, we intend to outline how we will reflect new ways of thinking in the Travel & Tourism sector for the next decade.

We are very proud to be able to attract this prestigious global event to Quintana Roo, which will focus the attention of the global tourism leaders towards Cancun and Quintana Roo, as well as the whole country, said Carlos Joaquin Gonzalez, Governor of the State of Quintana Roo.

In Quintana Roo,we have the fortune of relying on tourism as one of the key pillars of investment, employment, and economic prosperity in coordination with government, businesses and the community. We have positioned ourselves as the leader in international arrivals in Mexico and Latin America.

Gloria Guevara, President & CEO, WTTC, said:

The WTTC Global Summit will be the most important Travel & Tourism event of 2020,and a fitting recognition of a sector which last year, contributed 10.4% to global GDP and supported 319 million jobs worldwide.

The 20th Global Summit will benefit and showcase not only Quintana Roo,but Mexico, and the whole region including US, Canada, Latin America and the Caribbean. Cancun is a global icon and I feel honored to host the most important Travel & Tourism event of the year in my home country. Our Summit is the place where the future of our sector is shaped, and we look forward to hearing the insight of so many industry leaders,as we welcome them to our stage.

eTurboNews is a media partner of the WTTC summit.

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Who will speak at the WTTC Summit in Cancun? - eTurboNews | Trends | Travel News

Ramsay World Travel on the move in Dunfermline – Dunfermline Press

RAMSAY World Travel are going places with a new shop set to open in Dunfermline.

Subway moved from Douglas Street into the Kingsgate Shopping Centre recently and the holiday firm are making the opposite journey, taking over the empty premises in Douglas Street.

Commercial manager Dave Terry said: "The new shop opens on Monday, February 17.

"It's a really good area; it's on the street from the bus station and the Kingsgate and two seconds from the High Street.

"I think that's going to be perfect; it's a bigger shop too so we can get more desks in.

"We will be recruiting, yes, we've got seven at the moment and will be moving up to 10 staff.

"Basically, the idea is to get more business which means more staff."

Asked why they were moving out of the Kingsgate, he explained: "We've bought the premises in Douglas Street.

"Our company policy now is to buy the premises where previously we've rented.

"We wanted to be out on the street and closer to the High Street too as it's better for us.

"Most of our shops are a hop, skip and a jump from the high street; it works for us as you don't have to pay the high costs but you get the benefits from it."

It's a financial commitment from Ramsay World Travel, who are investing in the town centre when others are moving out.

Mr Terry said the model works for them and added: "We get a lot of business from the website and from Facebook but the shops are our bread and butter.

"There are still a lot of people who want to come in, sit down and get some advice about booking their holiday.

"What advice can you give someone on a computer?

"How do they know they're getting the best deal or the best hotel?

"With us, they can ask questions and we have the knowledge to advise them.

"I know a lot of companies have moved completely onto the internet but we'll always have shops."

He added: "We've just had our accounts through which show our turnover has increased, year on year, for the 35th year in a row.

"What's it down to? Hard work I suppose.

"Every year since we started we've managed to increase the turnover and profits and this year was no exception."

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Ramsay World Travel on the move in Dunfermline - Dunfermline Press

Discover how Global Customized Travel Market Increase in need for business agility and faster operational decisions of Industry, Top key players like…

The Global Customized Travel Market report draws precise insights by examining the latest and prospective industry trends and helping readers recognize the products and services that are boosting revenue growth and profitability. The study performs a detailed analysis of all the significant factors, including drivers, constraints, threats, challenges, prospects, and industry-specific trends, impacting the market on a global and regional scale. Additionally, the report cites worldwide market scenario along with competitive landscape of leading participants.

Get Sample Copy of the Report @ https://www.reportsweb.com/inquiry&RW00013233484/sample

The Customized Travel market analysis is intended to provide all participants and vendors with pertinent specifics about growth aspects, roadblocks, threats, and lucrative business opportunities that the market is anticipated to reveal in the coming years. This intelligence study also encompasses the revenue share, market size, market potential, and rate of consumption to draw insights pertaining to the rivalry to gain control of a large portion of the market share.

Leading Players in the Customized Travel Market: DuVine Cycling & Adventure Co, TCS World Travel, Heritage Tours, INTRAV, Asia Transpacific Journeys, Mountain Lodges of Peru, Boundless Journeys, Backroads, VBT Bicycling & Walking Vacations, Classic Journeys, Tamarind Global, Gray & Co, Gojourney, Trip.me, Abercrombie & Kent, Journeys Within, Zicasso, Global Custom Travel and more

Competitive landscape

The Customized Travel Industry is extremely competitive and consolidated because of the existence of several established companies that are adopting different marketing strategies to increase their market share. The vendors engaged in the sector are outlined based on their geographic reach, financial performance, strategic moves, and product portfolio. The vendors are gradually widening their strategic moves, along with customer interaction.

Customized Travel Market Segmented by Region/Country: US, Europe, China, Japan, Middle East & Africa, India, Central & South America

For discount click here: https://www.reportsweb.com/inquiry&RW00013233484/discount

Type of Customized Travel Market:

Within 7 days

7-15 days

More than 15 days

Application of Customized Travel Market:

Sightseeing

Business Travel

Education

Others

Points Covered in the Report:

Access full Report Description, TOC, Table of Figure, Chart, etc. @ https://www.reportsweb.com/buy&RW00013233484/buy/2950

Thanks for reading this article; you can also customize this report to get select chapters or region-wise coverage with regions such as Asia, North America, and Europe.

Table of Content

Chapter 1: Industry Overview

Chapter 2: Customized Travel Market International and China Market Analysis

Chapter 3: Environment Analysis of Market.

Chapter 4: Analysis of Revenue by Classifications

Chapter 5: Analysis of Revenue by Regions and Applications

Chapter 6: Analysis of Customized Travel Market Revenue Market Status.

Chapter 7: Analysis of Industry Key Manufacturers

Chapter 8: Conclusion of the Customized Travel Market Industry Research Report.

Continued to TOC

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Wyndham Grand Algarve opens in Portugal | News – Breaking Travel News

Wyndham Grand Algarve has opened in the famous golf destination of Quinta do Lago, marking the brands debut in Portugal.

The hotel is nestled in the coveted resort, a world-famous golf and holiday destination, in the heart of the Ria Formosa Natural Park and within walking distance of Quinta do Lago beach.

It features 132 elegant suites with one or two bedrooms, luxury amenities, a balcony or terrace and complimentary Wi-Fi.

The property offers multiple dining options, a full-service spa, state-of-the-art fitness centre, indoor and outdoor pool, and kids clubs. Six renowned golf courses are nearby, as is Quinta do Lagos sports campus, which offers tennis, swimming, football and much more.

Wyndham Grand Algarve is located 25 minutes from Faro Airport and offers VIP transfers, making it an ideal getaway for international guests.

The debut is the latest in the brands recent expansion to more sought-after destinations around the world.

In 2019 alone, Wyndham Grand entered Georgia (Tbilisi), Croatia (Novi Vinodolski), the Greek Islands (Crete) and added other iconic properties in Turkey, California, Vietnam and Mexico.

Other top destinations for Wyndham Grand include Shanghai, Istanbul, Salzburg, Athens, Manama, Chicago, Orlando, amongst others.

Its future expansion plans include a pipeline of 20 additional hotels in various destinations, including St. Kitts and Nevis, Barbados, Belize and a new dual-branded Wyndham Grand and TRYP by Wyndham hotel in Miami, Florida.

Dimitris Manikis, managing director for EMEA, Wyndham Hotels & Resorts, said: We are thrilled to have expanded our upper-upscale offering for our guests travelling across EMEA.

From Georgia to Greece, Turkey and now Portugal, we now have even more options to suit our travellers needs combining one-of-a-kind experience with accessible luxury.

This stunning location in the Algarve is the perfect spot to introduce our iconic brand to Portugal.

With over 20 million overnight stays recorded in the first eleven months of 2019 alone, the Algarve continues to attract more travellers and we are delighted to expand our collection in Portugals southernmost region.

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Wyndham Grand Algarve opens in Portugal | News - Breaking Travel News

Inside the WTM London @ 40 – THISDAY Newspapers

For four decades, the World Travel Market has become a rendezvous for over 200 countries every year. As the largest travel expo in the world, it has helped to build many tourism businesses. Funke Olaode, who participated in the recent three-day expo held in Excel, East London, United Kingdom, finds out how the WTM has fared.

World Travel Market came to being 40 years ago when it held its first exhibition in 1979. And over the last 40 years, the WTM which is usually organized in London, United Kingdom has remained a melting point for over 200 countries, welcoming 51,500 senior travel industry professionals, government ministers, and international media who visit Excel-London every November, thereby generating around 4 billion of travel industry contacts.

The expansive exhibition center in Excel, Custom House in East London has become a mecca of sorts for tour operators, travels experts, and hospitality industry from around the world as they jostle for attention from visitors to catch a glimpse of what they can offer in their various countries.

From November 4 to 6, 2019, the world again converged on the British soil to rub minds together on how to take advantage of the platform and at the same time proffer the way forward for tourism and travels across the world as many nations prepare to diversify.

The 2019 exhibition was special as it marked the four decades of its establishment. In what one could tag a show of spectacular, various countries tried to outdo themselves with their breathtaking pavilions. Not knowing to things in half measure, the gulf country such as Saudi Arabia showcased one of the best pavilions while the Emirate and middle east consists of Dubai, Abu Dhabi, Oman, Jordan were on ground to treat the visitors to their hospitality as they offer goodies in different forms to visitors who had a brief stop at their domain. Their damsels were beauties to behold as they all dressed up in their various traditional attires. And of course, countries like the United States, Middle East, Asia, and Africa also put up electrifying pavilions.

How has WTM fared in the last 40 years? Has WTM lived up to expectations? To some experts, it has as many countries have continued to embrace tourism as the next cash cow to boost their GDP.

While some embark on advertisements in local and international media to showcase their tourism potential, the impact of this annual expo in using tourism as a vehicle to boost the nations economy cannot be over-emphasized as it brings face-to-face representatives of various countries and prospective tourists.

For instance, in a recent report, the United Arab Emirates (UAE) with its famed Abu Dhabi and Dubai sits atop over 93 billion barrels of crude oil. But as it stands today, the country has since put oil aside and embrace tourism is its cash cow.

With its less than six million population and a GDP per capita predicted to rise by 22 percent to just $75 in a few years time, Dubai, a city of superlatives, pristine beaches and an interesting mix of indoor and outdoor entertainments, has in the last few years been playing host to thousands of visitors from all over the world. Dubais ambition to become the worlds most visited city is obvious.Tourism is an important part of the Dubai governments strategy to maintain the flow of foreign cash into the emirate. As of 2013, Dubai was the fourth most visited city of the world based on air traffic and the fastest-growing, increasing by a 10.7 percent. Dubai attracts at least 14 million tourists in 2015. And by the end of 2015, the countrys gross domestic product stood at $340.8 billion. Towards the end of 2018, Dubai welcomed its 1 billion visitors to her domain. This feat was celebrated.

Another example of a nation that has shifted focus beyond oil and embrace tourism fully is Turkey. Istanbul welcomes thousands of visitors daily. Turkey is a nation straddling Eastern Europe and Western Asia with cultural connections to ancient Greek, Persian, Roman, Byzantine, and Ottoman empires. Cosmopolitan Istanbul, on the Bosporus Strait, is home to the iconic Hagia Sophia, with its soaring dome and Christian mosaics, the massive 17th-century Blue Mosque and the 1460 Topkap Palace the former home of sultans.

During this reporters visit to the ancient city in 2015, a tour guide at Hagia Sophia Mosque explained that an average 3,000 visitors converge at the iconic site daily at $10 per head.

About three years ago, Barbados celebrates its 50 years of independence. The Island was one of the first European colonies in the Caribbean that broke from the British rule on November 30, 1966. The last five decades have seen its tourism industry rise to overtake sugar production as the Islands major source of income.

The countries such as the Middle East, the Caribbean, and godfathers of destinations: the UK, the United States, Germany, even South Africa and Kenya have continued to position themselves as tourists havens and are raking multimillion dollars.

In recent times, Ethiopia, Rwanda Tanzania, Kenya, and The Gambia have demonstrated how lucrative travels and tourism are. The Gambia, with a population of about 1.849 million as of 2013 and over 30 top tourist attractions receives over 100,000 visitors a year and its tourism industry is the second-highest earner of foreign revenue.

In spite of domestic challenges back home, Kenya, Uganda, and Rwanda have not failed to take advantage of the WTM. The trio marketed themselves as a single destination for the first time at a joint stand during 2017 WTM London under the banner, Borderless Borders, One Destination. The single East Africa Tourist Visa, recently launched, enables travelers to visit Kenya, Uganda, and Rwanda under one visa.

South Africa is a popular tourist destination and the industry accounts for a substantial amount of the countrys revenue. According to the World Travel and Tourism Council, the tourism industry directly contributed ZAR 102 billion to South African GDP in 2012 and supports 10.3 percent of jobs in the country. Another important source of revenue is domestic tourism, which contributes 52 percent of total tourism consumption. The number of tourists that throng South Africa also reached the ten million mark in 2014.

However, West Africa still appears to lag behind and even below the average growth rate of tourism development in the Continent.

Commenting on how WTM, London has impacted professionals as well as stakeholders, Lagos based travels and aviation expert, Mr. Wole Shadare commended the visionary leadership of the WTM.

The Exhibition Centre is a massive edifice that attracts common interests. It is an avenue for stakeholders to keep up with the latest insights on travel. WTM London, the leading global event for the travel industry, is the must-attend four day business to business exhibition for the worldwide travel and tourism industry. For 40 years, the worlds largest travel trade show has performed creditably well and lived up to expectations. Year in year out, exhibitors from more than 200 countries pack into Excel London to conduct close to 4b deals that shape the future of travel.

On the failure of Nigeria to register its presence over the last five years, Shadare said it has raised a lot of concern. For five years running, the ability of Nigeria to take part in yearly World Travel Market in London and other places has raised a great concern of how the country has not taken the opportunity to market Nigeria vast tourism potentials. Not a few are surprised that the Federal or states government are not marketing Nigeria to the world like Egypt, South Africa, Rwanda, and Morocco are doing. This is a huge mistake because we could have used the opportunity to sell Nigeria to the outside world.

On how the platform has become his source of knowledge, initiator of Akwaaba Travels and Tourism and publisher of Travellers Magazine, Nkechi Uko, said WTM over the years had served as his personal training school.

Going down memory lane, Uko said, Nigeria made its maiden appearance sometimes in 1998 when British Airways took Four Nigerian Travel Agents Members of NANTA to London when the expo was still being held at Olympia. And over the years, it has become a pilgrimage for travel experts to strike a multi-million deals while many countries are using tourism to drive their economy.

As the world embraced tourism as an alternative source of income, unfortunately, Nigeria has taken a step backward over the last five years shying away from several attractive sites scattered across its 36 states. The question still remains. Will Nigeria reclaims her place among the comity of African nations in the coming years ahead? Only time will tell.

As the WTM enters its fifth decade, many hope it will keep the tempo going as many nations have come to see great potential in tourism, travels, and hospitality.

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Inside the WTM London @ 40 - THISDAY Newspapers

5 of the world’s best Ferris wheels – World First Travel Insurance

12 February 2020 08:59

Discover the world's best Ferris wheels

From the tallest to the brightest and a few in between, is there any better way to experience a new destination than from above? Discover new skylines around the world aboard these fantastic Ferris wheels...

Take a trip to Vienna and experience the world's oldest operating ferris wheel. First constructed in 1827, this world-famous wheel stands 65 metres tall over Prater amusement park, home to a number of other classic attractions such as carousels, a ghost train and hall of mirrors. Riesenra is open all year round, offering breathtaking views of the historic city from winter through summer.

If it's height that impresses you, head over to the Nevada desert for a ride on the aptly named High Roller, towering a huge 550 feet over the centre of the Las Vegas Strip. As the world's tallest observation wheel (at least for now), the High Roller offers riders 360 degree views of Las Vegas Valley. Some cabins even come with an open bar service!

Standing 100 metres high over Yokohama's Minato Mirai district, take to one of Cosmo Clock 21's 60 colourful gondolas and enjoy views of everything from Yokohama Landmark Tower and Yokohama Bay, to Mt. Fuji and the Shinjuku skyscrapers. If you're in the mood to ride twice, Cosmo is a must-see at night too, with the wheel itself illuminated by an incredible light show.

Definitely worth a visit is the Yongle Bridge Tianjin Eye, the only ferris wheel in the world built over water. Constructed on a bridge over the Hai River, the Tianjin Eye is a steady 20 to 40 minute ride depending on the weather, offering plenty of time to enjoy the surrounding scenery.

Step off at Santa Monica Pier to experience the world's only solar-powered Ferris wheel. Featuring more than 174,000 energy-efficient lights, this quirky attraction comes into its own after dark with dynamic, computer generated light shows offering dramatic entertainment to brighten your evening.

At World First we offer worldwide travel insurance so can enjoy the views, wherever your adventures take you.

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5 of the world's best Ferris wheels - World First Travel Insurance

Bioprocessing Summit Europe Highlights Innovations in Gene Therapy CMC and Manufacturing – Yahoo Finance

Spark Therapeutics, Ultragenyx and Others to Headline March 24-26 Meeting in Barcelona

With the global market for gene therapy expected to hit $13 billion (USD) by 2024 (Research And Markets), Bioprocessing Summit Europe is returning March 24-26, 2020 with its popular Gene Therapy CMC and Manufacturing track.

Expanding to a new venue to accommodate increased registrations, the meeting will take place at The Crowne Plaza Barcelona (Spain)Fira Center.

From the Plenary Keynote by Diane Blumenthal, PhD, Head, Technical Development, Spark Therapeutics, the first company to obtain approval of a gene-therapy product in the EU and US, to insights from Biogen, Sanofi, Vivet Therapeutics, Takeda and Ultragenyx, content will focus on accelerating therapies into the market.

"There is a real thirst for knowledge about how to rapidly deploy biologics while ensuring quality and cost-efficiency. This conference reveals the critical challenges facing the manufacture, analysis and control of these exciting new therapies," said Dan Barry, Senior Conference Director, CHI.

Among highlights:

The event will also include:

See bioprocessingeurope.com.

About Cambridge Healthtech InstituteCambridge Healthtech Institute (CHI), a division of Cambridge Innovation Institute, is the preeminent life science network for leading researchers and business experts from top pharmaceutical, biotech, CROs, academia, and niche service providers. CHI is renowned for its vast conference portfolio held worldwide including PepTalk, Molecular Medicine Tri-Conference, SCOPE Summit, Bio-IT World Conference & Expo, PEGS Summit, Drug Discovery Chemistry, Biomarker World Congress, World Pharma Week, The Bioprocessing Summit, Next Generation Dx Summit, Immuno-Oncology Summit, and Discovery on Target. CHI's portfolio of products include Cambridge Healthtech Institute Conferences, Barnett International, Insight Pharma Reports, Bio-IT World, Clinical Research News and Diagnostics World.

View source version on businesswire.com: https://www.businesswire.com/news/home/20200211006146/en/

Contacts

Dawn Ringel+1-781-449-8456, dawn@ringelpr.com

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Bioprocessing Summit Europe Highlights Innovations in Gene Therapy CMC and Manufacturing - Yahoo Finance

University of Minnesota Medical School Ranks 27th in 2019 NIH Rankings – Yahoo Finance

The U of M increases three spots in Blue Ridge Institute of Medical Research rankings

Minneapolis, MN, Feb. 12, 2020 (GLOBE NEWSWIRE) -- The Blue Ridge Institute for Medical Research recognizes the University of Minnesota Medical School as the 27th most funded institution by the National Institutes of Health (NIH) in the 2019 NIH rankings.

The University of Minnesota Medical School is ranked 27th nationally in this years rankings, improving from last years spot as 30th (and 33rd in 2017). In addition, five of the Medical Schools departments Biochemistry, Molecular Biology and Biophysics; Neuroscience; Family Medicine and Community Health; Pediatrics; and Rehabilitation Medicine ranked in the top 10 for department-specific rankings. Several other departments also improved rankings in 2019.

The continued progress of our medical school's climb in the NIH rankings reflects the incredible work taking place every day on our campus and in our healthcare facilities by our faculty, researchers and students, said University of Minnesota President Joan T.A. Gabel. We look forward to building on this sustained success as we seek to solve the most pressing healthcare issues here in Minnesota and around the world."

The NIH is the largest federal provider of basic research money to universities. Each year, the Blue Ridge Institute evaluates NIH data tables and ranks universities based on their annual NIH grant support. Improving the Medical School rankings is a top priority of the Board of Regents as a measure for advancing the University.

Rankings are good indicators of how we are building momentum at the Medical School, said Jakub Tolar, MD, PhD, Dean of the University of Minnesota Medical School and Vice President for Clinical Affairs. They help us recruit and retain our faculty, physicians, staff, and learners, generate community support, and most importantly build trust with our patients. We are grateful for the support of President Gabel and our Board of Regents, as well as the strong partnership we have with the State of Minnesota in advancing our mission.

About the University of Minnesota Medical School

The University of Minnesota Medical School is at the forefront of learning and discovery, transforming medical care and educating the next generation of physicians. Our graduates and faculty produce high-impact biomedical research and advance the practice of medicine. Visit med.umn.edu to learn how the University of Minnesota is innovating all aspects of medicine.

Naomi McDonaldUniversity of Minnesota Medical School6123019525naomim@umn.edu

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University of Minnesota Medical School Ranks 27th in 2019 NIH Rankings - Yahoo Finance

Study Shows That Caris Life Sciences’ ADAPT Biotargeting System Has Discovered Protein Expression Pattern Differences Between Two Prostate Cancer…

First time findings published in Nucleic Acids Research demonstrate the ability to differentiate exosomes from cancer cell subtypes from the same tumor type offering broad potential applications in biomarker discovery

IRVING, Texas, Feb. 12, 2020 /PRNewswire/ -- Caris Life Sciences, a leading innovator in molecular science focused on fulfilling the promise of precision medicine, today announced the publication of new data in Nucleic Acids Research,illustrating that use of the Company's proprietary ADAPT Biotargeting System can lead to the identification of differences in protein expression patterns between exosomes from two related prostate cancer cell lines, vertebral cancer of the prostate (VCaP) and lymph node cancer of the prostate (LNCaP).

Caris Life Sciences Logo (PRNewsfoto/Caris Life Sciences)

The paper, "ADAPT identifies an ESCRT complex composition that discriminates VCaP from LNCaP prostate cancer cell exosomes," also demonstrates that the ADAPT platform can be a powerful method that allows for the enrichment of polyligands that can distinguish even between different subpopulations of the same disease.

The results show that the ADAPT Biotargeting System has the resolution and sensitivity to discover differences in protein complexes using exosomes secreted by cancer cells from the same tumor type.

"The results of this research are highly significant in that they show that the ADAPT system can be deployed against multiple cancer types in various biological matrices and offers broad potential applications in biomarker discovery," said David Spetzler, M.S., Ph.D., M.B.A., President and Chief Scientific Officer of Caris Life Sciences, and an author of the study. "Further, we were able to show that in prostate cancer, ADAPT not only discriminated between cancer types but between subtypes of a specific lineage. We anticipate that this could potentially help inform treatment decisions based on the patient's specific molecular profile in prostate cancer and across a range of tumor types."

"The differences in the composition of the Endosomal Sorting Complex Required For Transport (ESCRT) pathway and associated complexes between exosomes derived from VCaP and LNCaP cells could point to them as novel biomarkers for these different prostate cancers," said Michael Famulok, Ph.D., University of Bonn (Germany), Life & Medical Sciences Institute (LIMES), Max Planck Fellow and co-author of the study. "We look forward to further investigating this potential and how the ADAPT system can be used to gain a greater understanding of the molecular composition of cells across tumor types."

The ADAPT Biotargeting System is Caris' proprietary unbiased profiling platform that uses a broad library of synthetically-manufactured molecules (aptamers) that bind to a wide range of biological targets and characterize complex biological systems in their native state, enabling them to profile biological samples at a systems-wide scale.

Thepaperwaspublishedonline on January 28 inNucleic Acids Research,andisavailableonlinehere and DOI:https://doi.org/10.1093/nar/gkaa034.

About Caris Life Sciences

Caris Life Sciences is a leading innovator in molecular science focused on fulfilling the promise of precision medicine through quality and innovation. The company's suite of market-leading molecular profiling offerings assesses DNA, RNA and proteins to reveal a molecular blueprint that helps physicians and cancer patients make more precise and personalized treatment decisions.

Story continues

Caris is also advancing precision medicine with Next Generation Profiling that combines its innovative service offerings, Caris Molecular Intelligence and ADAPT Biotargeting System, with its proprietary artificial intelligence analytics engine, DEAN, to analyze the whole exome, whole transcriptome and complete cancer proteome. This information, coupled with mature clinical outcomes on thousands of patients, provides unmatched molecular solutions for patients, physicians, payers and biopharmaceutical organizations.

Whole transcriptome sequencing with MI Transcriptome provides the most comprehensive and unique RNA analysis available on the market and covers all 22,000 genes, with an average of 60 million reads per patient, to deliver extremely broad coverage and high resolution into the dynamic nature of the transcriptome. Assessing the whole transcriptome allows us to dig deeper into the RNA universe to uncover and detect fusions, splice variants, and expression changes that provide oncologists with more insight and actionable information when determining treatment plans for patients.

Caris Pharmatech, a pioneer of the original Just-In-Time research system with the largest research-ready oncology network is changing the paradigm from the traditional physician outreach model to a real-time approach where patient identification is completed at the lab and the physician is informed so that the patient can be enrolled days earlier, and remain in the local physician's care, without having to travel to a large central trial site. This fundamentally redefines how pharmaceutical and biotechnology companies identify and rapidly enroll patients in precision oncology trials by combining Caris' highest quality industry leading large-scale molecular profiling services with Pharmatech's on-demand site activation and patient enrollment system.

Headquartered in Irving, Texas, Caris Life Sciences offers services throughout the U.S., Europe, Asia and other international markets. To learn more, please visitwww.CarisLifeSciences.comor follow us on Twitter (@CarisLS).

Media Contact:Lindsey BailysGCI Healthlindsey.bailys@gcihealth.com +1-212-798-9884

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Study Shows That Caris Life Sciences' ADAPT Biotargeting System Has Discovered Protein Expression Pattern Differences Between Two Prostate Cancer...

Myriad Genetics to Present at the SVB Leerink Global Healthcare Conference – Yahoo Finance

SALT LAKE CITY, Feb. 12, 2020 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (MYGN), a leader in molecular diagnostics and personalized medicine, announced that R. Bryan Riggsbee, president and CEO, is scheduled to present at the SVB Leerink Global Healthcare Conference at 10:30 a.m. EST on February 25, 2020 in New York City.

The presentation will be available to interested parties through a live audio webcast accessible through a link in the investor information section of Myriads website at http://www.myriad.com.

About Myriad GeneticsMyriad Genetics, Inc., is a leading precision medicine company dedicated to being a trusted advisor transforming patient lives worldwide with pioneering molecular diagnostics. Myriad discovers and commercializes molecular diagnostic tests that: determine the risk of developing disease, accurately diagnose disease, assess the risk of disease progression, and guide treatment decisions across six major medical specialties where molecular diagnostics can significantly improve patient care and lower healthcare costs. Myriad is focused on five critical success factors: building upon a solid hereditary cancer foundation, growing new product volume, expanding reimbursement coverage for new products, increasing RNA kit revenue internationally and improving profitability with Elevate 2020. For more information on how Myriad is making a difference, please visit the Company's website: http://www.myriad.com.

Myriad, the Myriad logo, BART, BRACAnalysis, Colaris, Colaris AP, myPath, myRisk, Myriad myRisk, myRisk Hereditary Cancer, myChoice, myPlan, BRACAnalysis CDx, Tumor BRACAnalysis CDx, myChoice CDx, EndoPredict, Vectra, GeneSight, riskScore Prolaris, ForeSight and Prequel are trademarks or registered trademarks of Myriad Genetics, Inc. or its wholly owned subsidiaries in the United States and foreign countries. MYGN-F, MYGN-G.

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It’s all in the delivery nanoparticle platform could transform medical treatments – Princeton University

Optimeos Life Sciences, a startup founded by two Princeton University faculty members, has reached agreements with six pharmaceutical companies to develop therapeutics using a Princeton-developed drug delivery technology. The collaborations have the potential to improve the effectiveness of medications for the treatment of diseases, ranging from cancer to diabetes.

Optimeos, founded in 2016 by Robert Prudhomme, professor of chemical and biological engineering, and Shahram Hejazi, a faculty memberinthe Keller Center for Innovation in Engineering Educationandelectrical engineering,focuses on bringing technology developed over 15 years in Prudhommes lab to market. The technology, called flash nanoprecipitation, enables the encapsulation of drugs into nanoscale particles that improve delivery and effectiveness.

The startupOptimeos,founded by two Princeton faculty members, has agreements with pharmaceutical companies to bring a nanoscale drug delivery system to market. Developed in Robert Prudhommes lab, the system is a vehicle for delivering medications to precise locations in the body or the interior of cells to treat myriad diseases, including cancer and diabetes. Shown is an artists rendering of Optimeos nanoparticle system.

Illustration by Rachel Davidowitz

The new venture extends the impact of the technology, which already is being used in a project with the Bill and Melinda Gates Foundation. The foundation awarded Prud'homme'slab a $1.2 million grant in 2016 to apply their technology to increase the effectiveness of drugs used in global health. Solutions for global health problems have to be low cost and robust, and the flash nanoprecipitation process is both. The method has been applied to three drugs sponsored by the Gates Foundation. The first was for a drug to treat diarrhea in infants caused by drinking polluted water, the second a tuberculosis drug, and the third a single-dose treatment for malaria.

Optimeos new agreements involve creating improved delivery methods for six different medicines. The names of the six biopharmaceutical companies are currently undisclosed due to the proprietary nature of the ventures. The targeted indications for the various projects are immuno-oncology, autoimmune diseases, diabetes, diseases of the central nervous system and ocular diseases.

These new projects address an inverse set of constraints to that of the Gates Foundation. With Gates, the goal is to take drugs that normally dissolve poorly in the body, because they are water-resistant, and use the delivery system to increase absorption. These projects also need the formulations to be inexpensive, as well as impervious to high humidity and other extreme storage conditions. In contrast, the drug companies working with Optimeos need methods for delivering highly soluble biologics a class of therapeutics including proteins, peptides and nucleic acids.The structural complexity of biologics imparts higher potency and greater specificity, which causes fewer side effects. However, biologics require delivery through frequent injections, and their activity is restricted to targets outside the walls of individual cells, unless sophisticated pharmaceutical formulations are used.

The future of therapeutics are potent biological drugs, many of which have delivery challenges with respect to how much drug needs to be delivered to exactly where in the body, while minimizing side effects, Hejazi said.

Optimeos is overcoming the limitations of biologics by encapsulating them into carefully designed nanoparticles that are 10-times smaller than a red blood cell, or into larger microparticles about the width of a human hair. Such particles have been difficult to manufacture in a reproducible and scalable way, until now.

To make these particles, Optimeos first creates primary nanoparticles in which the drug-filled core is covered by a skin of specially designed polymers. These primary nanoparticles can then be coated with additional polymers that are engineered to interact with specific tissues or cells in the body. These coated nanoparticles could deliver drugs to more precise locations in the body or into the interior of cells. Alternatively, the primary nanoparticles can be assembled into larger composites, much like a cluster of grapes. These microparticles slowly release the encapsulated therapeutic, over a period of weeks to months.

One use of these slow-releasing particles is in the treatment and management of diabetes. In 2019, Optimeos received funding through a National Science Foundation grant to develop a once-monthly injection of liraglutide, a non-insulin medicine used to treat type II diabetes and obesity. Liraglutide is currently administered by a daily injection. The Optimeos formulation aims to reduce the total amount of drug needed, reduce side effects and reduce the frequency of injections. These attributes enhance patient comfort, adherence to treatment regimens, quality of life, cost of care, as well as the medical outcomes, said Robert Pagels, director of R&D for the company and former graduate student of Prudhomme.(As a student in 2017, Pagels' pitch of the technology won first place at the Keller Center's annual Innovation Forum.)

What makes Optimeos approach novel is that the particles can be easily scaled to accommodate mass production needed for the marketplace. I would say none of the technologies out there that are being published on or worked on can be, in fact, scaled up," said Hejazi.

As the onetime head of the Kodak Molecular Imaging Group, now Carestream, Hejazi knew that a persistent problem in the marketplace is that many innovations in nanotechnology cannot be reproduced consistently at industrial scales. Flash nanoprecipitation and its corollary, called inverse flash nanoprecipitation, solve that problem, Hejazi said.

Most methods of creating nanoparticles require combining active ingredients in precise proportion to each other to create consistently sized nanoparticles. This can often be done effectively in small volumes in the laboratory, but cannot be translated to large-scale production. To solve this challenge, flash nanoprecipitation uses multiple, continuous, high-velocity streams containing the active ingredients that constantly combine at the correct proportions within specially engineered mixing chambers. To create more nanoparticles, the process can be left to run over longer time periods. To increase speed of production, the thickness of the streams can be increased, as long as they are in correct proportion to each other. In effect, it is an assembly line approach to mixing the agents.

Pictured at Princeton Innovation Center BioLabs, team members from left: Shahram Hejazi, Bumjun Kim, Robert Pagels, Robert Prud'homme, Chester Markwalter and Madeleine Armstrong.

I have always been passionate about solving health care problems, said Hejazi. Through his industrial contacts, he identified problems the technology could potentially solve. Once the researchers demonstrated that the technology could meet industry demands, the team filed a patent for inverse flash nanoprecipitation in 2016. This patent, written by Pagels and Prudhomme, details how the flash nanoprecipitation process can be used to encapsulate water-soluble drugs such as biologics. This was a major innovation first developed by Pagels in his doctoral research. He flipped the flash nanoprecipitation process (hence the term inverse) to encapsulate soluble drugs, rather than water-insoluble drugs. This made the technology applicable to biologics, and opened up this fast-growing market as a potential target.

Hejazis experience in industry and venture capital provided the vision that drove the founding of the company. Hejazi helped to raise capital, and the team formed a sponsored research agreement with Princeton to continue developing the technology at Princeton. Optimeos also hired recent graduates from Prudhommes lab to work in the company.

Prudhomme sees Optimeos bringing his scientific goals to fruition. My academic research has focused on understanding the fundamental principles behind polymer assembly and processing to enable us to make elegant nanoparticles, said Prudhomme.However, as an engineer, I also want to do something that can make an impact on human health, as opposed to just trying to do a one-shot thing that is beautiful and advances science.

Optimeos story is part of a wider effort at Princeton to move discoveries from University labs to the market and to benefit society more broadly.

The Office of Technology and Licensing at Princeton educates researchers in the steps needed to commercialize technologies and offers entrepreneurial resources, said Anthony J. Williams, new ventures associate in the office.

In recent years, the technology licensing office at Princeton has doubled the creation of startups growing out of faculty research.

Princeton and other universities have been commercializing research since the 1980s when the Bayh-Dole Act allowed institutions to market research that was funded through federal grants. Since then, some of the biggest entrepreneurial success stories at Princeton have been the drug Alimta, a highly effective drug for certain lung cancers, and a breakthrough that tripled the effectiveness of organic LEDs (OLEDS), a display technology now widely used in flat-screen televisions and smartphones.

Princeton isnt an ivory tower," said Williams. Princeton is developing a lot of innovative technologies and a lot of great inventions that can do good in the world.

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It's all in the delivery nanoparticle platform could transform medical treatments - Princeton University

No. 474: On molecular diagnostics, robo-busts and T Rex and happy birthday to the author of your youth – Innovate Long Island

Back stretch: Welcome to Wednesday, dear readers, and the clubhouse turn of our latest socioeconomic sprint.

Have you seen me: National Lost Penny Day on Lincolns birthday? Makes cents.

Its Feb. 12 out there, replete with offbeat observations: choose from National Lost Penny Day, National Plum Pudding Day and Valentines Hug Day, a cuddly precursor to the big lovers day.

They do: Speaking of lovers, its also a notable date for same-sex unions National Freedom to Marry Day, which was actually started by a law firm but earns a shoutout here.

Georgia on our mind: To our many readers in The Peach State, a joyous Georgia Day, recalling the Feb. 12, 1733, establishment of the then-Colonial province.

Sparta something big: Happy anniversary also to Michigan State University, home of the mighty Spartans, founded on this date in 1855.

Face it: Turning to sports innovations, to the delight of receivers and the chagrin of dentists, the catchers mask was patented by inventor Frederick Thayer on Feb. 12, 1878.

And it was this date in 1879 when North Americas first artificial ice-skating rink opened inside Madison Square Garden.

But whos counting: Thomas Edison racked up nine total patents on Feb. 12 four in 1884, two in 1889 and three in 1895, including his incandescent electric lamp.

Other notable innovators earning patent protections on this date include automotive and electronics icon James Packard, who landed the very first of his 43 patents this covering an Igniting Device for Hydrocarbon Engines on Feb. 12, 1901.

Use it or lose it: Fiji was the first nation to ratify the historic Paris Agreement on climate change.

A change is gonna come: And it was this date in 2016 when Fiji became the first nation to ratify the Paris Agreement, an environmental accord under the United Nations Framework Convention on Climate Change.

One-hundred-ninety-four other countries including the United States, albeit temporarily would follow.

Honestly: Happy birthday, Abe an imperfect man with an unerring sense of justice, a leader during a time of unparalleled crisis and an enduring tribute to the solemn weight and responsibility of the U.S. presidency, Abraham Lincoln would be 211 years old today.

Also born on Feb. 12 were the king of origin stories, English naturalist Charles Darwin (1809-1882); American paleontologist Barnum Brown (1873-1963), who discovered the first Tyrannosaurus Rex fossils and evidence of many other dinosaur species; American physicist and Nobel laureate Julian Schwinger (1918-1994), who helped square quantum mechanics with Einsteins theory of relativity; and Swedish actress Maud Adams (born 1945), still the only performer to play two different Bond girls in the long-running spy series.

Its me, Judy: Blume has beaten back critics with numerous awards and 82 million copies sold.

Full Blume: And take a bow, Judy Blume the beloved (and sometimes controversial) author of honest, timeless and influential adolescent fiction turns 82 today.

Give your first favorite writer, your fathers 1974 fantasy woman and all the other Feb. 12 innovators your best at editor@innovateli.com give us the story tips and calendar items, please and thank you.

About our sponsor:Farrell Fritz, a full-service law firm with 15 practice groups, advises startups on entity formation, founder and shareholder agreements, funding, executive compensation and benefits, licensing and technology transfer, mergers and acquisitions and other strategic transactions.The firms blog,New York Venture Hub, discusses legal and business issues facing entrepreneurs and investors.

BUT FIRST, THIS

Park place: Albanys investments in New Yorks state parks appear to be paying off, with Gov. Andrew Cuomo trumpeting a banner year in 2019 for statewide park attendance including turnout at several recently refurbished Long Island sites.

New Yorks state parks, historic sites, campgrounds and officially sanctioned hiking trails welcomed a record-breaking 77.1 million visitors in 2019, an estimated 4 percent increase (nearly 3 million visitors) from 2018 numbers, according to the governors office, which also counts a roughly 33 percent jump (about 19 million annual visits) since Cuomo took office in 2011.

Cuomo credited efforts like the $90 million NY Parks 2020 plan, which has brought facility upgrades to Bethpage State Park (where annual attendance grew by 18 percent in 2019), Sunken Meadow State Park (annual attendance up 13 percent) and a host of other state properties on and off Long Island. The NY Parks 2020 initiative has revitalized our state parks and historic sites, Cuomo said Tuesday. Tourism is booming in New York and these beautiful sites are drawing visitors to all corners of the state.

Jeff Boyd: Molecule man.

Atta Boyd: A renowned expert in cancer genetics and clinical molecular diagnostics has joined the Northwell Health Cancer Institute.

Boasting three decades-plus of cancer-research experience, Jeff Boyd has been named vice president and chief scientific officer of the Cancer Institute and director of its Center for Genomic Medicine. Boyd, who most recently served as associate deputy director of the Miami Cancer Institute at Baptist Health South Florida, also will become a professor at Cold Spring Harbor Laboratory and member of the CSHL Cancer Center.

His primary function at the Northwell Health Cancer Institute will be heading up a new, state-of-the-art Molecular Diagnostics Laboratory the perfect challenge for the veteran researcher, according to Northwell Health Senior VP and Cancer Institute Director Richard Barakat. Genomics has become an important piece to helping us understand the genetic roots of the various forms of cancer, Barakat said Tuesday. We are extremely fortunate to have an internationally known genomics expert such as Dr. Boyd join the Cancer Institutes leadership team.

TOP OF THE SITE

Made for walking: And thats just what this multifaceted boot camp will do, not only teaching learners to code but putting them on the path to 21st century employment.

Robo cop: If Long Island-based autodialer assassin Nomorobo was any closer to a new federal crackdown on illegal robocalls, it would need a badge.

Growing Hain: Discontinued operations are still a drag, but the bottom line is slowly brightening for Lake Success-based global distributor Hain Celestial.

VOICES

Going to extremes: Students on the educational extremes special-ed students needing the most help, high-achieving aces needing more challenges have it roughest in distant rural districts. Voices columnist and K-12 education ace Harry Aurora wants to bring the solution to them.

STUFF WERE READING

Start your engines: Forbes takes a spin on the future of automotive innovation.

Water works: Engadget dives into rainwater as a renewable energy source.

Weather (or not): Popular Mechanics reviews 150 years of forecasting innovations.

RECENT FUNDINGS

+ Outset Medical, a California-based medtech developing innovative hemodialysis systems, raised $125 million in Series E equity financing led by D1 Capital Partners, with participation from Fidelity Management and Research Company, Partner Fund Management, Perceptive Advisor and funds advised by T. Rowe Price Associates.

+ Accion Systems, a Massachusetts-based in-space propulsion system provider, raised $11 million in Series B funding co-led by Boeing HorizonX Ventures and Shasta Ventures.

+ Sonoma Biotherapeutics, a California- and Washington State-based company developing regulatory T cell therapies for autoimmune and degenerative diseases, raised $40 million in Series A financing. Backers included Lyell Immunopharma, ARCH Venture Partners, Milky Way Ventures and 8VC.

+ Houwzer, a Pennsylvania-based real estate brokerage, raised $9.5 million in Series A funding led by Edison Partners, with participation from Admiral Capital Group and real estate investor Ira Lubert, and new investors GO Philly Fund and Chestnut Street Ventures.

+ Lumos Diagnostics, a Florida-based healthcare company providing complete point-of-care diagnostic test solutions, closed a $15 million Series A funding round. Australian commercialization company Planet Innovation made the investment.

+ Suzy, a New York City-based consumer-insight platform, closed a $12 million Series C funding round led by Bertelsmann Digital Media Investments, with participation from Foundry Group and Triangle Peak Partners, and existing investors Tribeca Venture Partners and 35 Ventures.

BELOW THE FOLD

Rocks solid: Behold, the new whiskey rebellion.

Eat: The Mars menu may convince astronauts to stay home.

Drink: What whiskey can teach us about innovation.

Be merry: Does innovation create happiness, or vice versa? You decide.

For tomorrow we fly: With the help of the Regulatory & Government Relations Practice Group and all the other topflight resources waiting at Farrell Fritz, one of the amazing firms that support Innovate LI. Check them out.

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No. 474: On molecular diagnostics, robo-busts and T Rex and happy birthday to the author of your youth - Innovate Long Island

$3.75m awarded to transform the way ovarian cancer is treated – News – The University of Sydney

Cancer Council has awarded its annual $3.75 million Translational Program Grant to a research team led by Professor Anna deFazio from the University of Sydney, exploring how to better personalise ovarian cancer treatment for Australian women.

Professor Anna deFazio and her team will spend the next five years creating a process by which ovarian cancer patients can have their cancer comprehensively analysed to determine its molecular profile. If standard treatments are not effective, patients can be matched with an appropriate clinical trial, based on the individual characteristics of their tumour.

This will improve treatment outcomes by ensuring that treatment approaches offered to an ovarian cancer patient are those with the highest likelihood of being successful for their specific subtype of the disease.

Professor deFazio, who is the Sydney West Chair in Translational Cancer Research and co-director of the Centre for Cancer Research at the Westmead Institute for Medical Research (WIMR), is hopeful that this research will transform the way women with ovarian cancer are treated.

Many people dont know that ovarian cancer has the lowest survival rate of any womens cancer in Australia, said Professor deFazio, from the University of Sydney School of Medicine in the Faculty of Medicine and Health.

Currently, only around 45 percent of ovarian cancer patients will survive for five years. Unlike many other cancers, these survival odds have only slightly improved in the last two decades one of the main reasons for this is that each ovarian cancer differs significantly in its genetic and molecular make-up, which results in widely varied treatment outcomes.

Encouragingly, the last few years have seen a rapid expansion in the number and variety of targeted cancer treatment options."

We will work to provide the missing link in this treatment path, generating the data and processes to match patients with the ideal treatment for their cancer type, said Professor deFazio.

The University of Sydney-led team has assembled an expert team of researchers and clinicians to make this happen, including from WIMR, The Crown Princess Mary Cancer Centre, Westmead Hospital, the Prince of Wales Hospital, Royal Hospital for Women, Royal North Shore Hospital, Royal Prince Alfred Hospital, Chris OBrien Lifehouse, the University of Technology Sydney, the Childrens Medical Research Institute, and from interstate, the Peter MacCallum Cancer Centre, and overseas, from the National Cancer Institute in the United States.

To reach their goal, Professor deFazios team will analyse the molecular profile of more than 300 ovarian cancer patients in NSW to better understand the subsets of ovarian cancer and how each type responds to specific treatments. The team will also look at ways of more simply communicating complex molecular test results to the treating clinical team, so they are easier to interpret.

Finally, Professor deFazios team will use patient samples to print 3D models of ovarian tumours to test treatment approaches and help design new early phase clinical trials.

Professor Karen Canfell, Director of Research at Cancer Council NSW, is proud the organisation was able to fund such innovative research: We only award our Translational Program Grant to cancer research that will rapidly translate research discoveries into clinical practice and policy, she said.

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$3.75m awarded to transform the way ovarian cancer is treated - News - The University of Sydney

Discovery raises Prospect of Universal Cancer Therapy – Labmate Online

The use of T-cell therapies for cancer - where immune cells are removed, modified and returned to the patients blood to seek and destroy cancer cells includes the use of CAR-T treatments which are personalised to each patient; however, this is said to target only a few types of cancers and has not been successful for solid tumours, which make up the vast majority of cancers.

Researchers at Cardiff University have now discovered T-cells equipped with a new type of T-cell receptor (TCR) which identifies and kills most human cancer types.

Conventional T-cells can recognise small parts of cellular proteins bound to cell-surface molecules called human leukocyte antigen (HLA), allowing killer T-cells to see whats occurring inside the cells by scanning their surface. HLA varies widely between individuals which has created barriers to creation of a T-cell-based treatment that can target most cancers in all people.

Now the findings of the Cardiff study(1) describe a unique TCR that can recognise many types of cancer via a single HLA-like molecule called MR1. Unlike HLA, MR1 does not vary in the human population - meaning it is a hugely attractive new target for immunotherapies.

T-cells equipped with the new TCR were shown, in the lab, to kill lung, skin, blood, colon, breast, bone, prostate, ovarian, kidney and cervical cancer cells, while ignoring healthy cells.

Professor Andrew Sewell, lead author of the study and an expert in T-cells from Cardiff Universitys School of Medicine, said: Cancer-targeting via MR1-restricted T-cells is an exciting new frontier - it raises the prospect of a one-size-fits-all cancer treatment; a single type of T-cell that could be capable of destroying many different types of cancers across the population. Previously nobody believed this could be possible.

Experiments are under way to determine the precise molecular mechanism by which the new TCR distinguishes between healthy cells and cancer. The researchers believe it may work by sensing changes in cellular metabolism which causes different metabolic intermediates to be presented at the cancer cell surface by MR1.

The Cardiff group hope to trial this new approach in patients towards the end of this year following further safety testing. Professor Sewell said a vital aspect of this ongoing safety testing was to further ensure killer T-cells modified with the new TCR recognise cancer cells only.

"There are plenty of hurdles to overcome; however if this testing is successful, then I would hope this new treatment could be in use in patients in a few years time, he said.

Further information at http://www.cardiff.ac.uk

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Discovery raises Prospect of Universal Cancer Therapy - Labmate Online