The term Nootropic was introduced in the early 1970s. Often referred to as cognitive enhancers or smart drugs, nootropics are compounds that are used to improve cognitive functions, such as attention, learning, concentration, memory, motivation, and problem solving. While all substances classified as nootropics demonstrate some form of mental enhancement, they all do so in unique ways, through different pathways and mechanisms in the body.[1,2]
The following list briefly covers the most common ingredients that appear in nootropic supplements. If you are interested in learning more, each ingredient has its own page providing further details.
Racetams are cognitive enhancers commonly used to treat a wide variety of neurological and neurodegenerative disorders.
This specific family of drugs branched off from the original "godfather" of nootropics, piracetam, which was discovered in the 1960's. Since then, the racetam family has expanded exponentially.
Nootropics were officially identified as a new class of drugs in 1972 when they were described as compounds that share the same essential characteristics as piracetam. Later, the definition of what constitutes a nootropic was changed. No longer was the compound necessarily required to resemble piracetam.[1,73]
Some of the popular members of the racetam family include:[74]
It has been documented that phenylpiracetam has a broader range of application, and is more powerful overall, than piracetam.[75,76]
Racetam uses:
They have also been shown to exhibit positive effects in regards to memory and learning [77, 78, 79, 80, 81, 82, 83, 84]
Noopept is an amino acid analogue that is very similar to piracetam, but is taken in far lower doses, and has shown to yield less side effects.
It increases the ability learn and remember information, and works by bettering your AMPA and NMDA Glutamatergic receptors, nerve growth factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), and acetylcholine levels.
You can read more about it on our Noopept "mega-post" on the blog.
Bacopa monnieri is a perennial plant that has a rich history in Ayurvedic medicine, where it is categorized as an herb that "assists the mind, and enhances awareness," according to several sources.
In Ayurveda, the traditional Hindu medicinal system based on the idea of balance in bodily systems using herbs, diet, and yogic breathing, it is commonly known as Brahmi, is used to treat depression, insomnia, epilepsy, and schizophrenia.[8] Various studies support the cognitive enhancing effects demonstrated by Bacopa, especially memory and attention.[9,10,11]
Choline is an essential nutrient required for healthy brain function. It can be synthesized by the body in small amounts, and up until recently, scientists believed that the body could compensate for choline deficits through other nutrients.
It is now accepted that choline is essential and needs to be consumed through diet or supplementation.[12,13] A number of studies have also verified choline's cognitive benefits. [14,15]
DMAE, which is sometimes referred to as deanol, is a precursor to choline. It allows the brain to optimize the production of acetylcholine, a primary neurotransmitter involved in cognitive functions, such as learning and memory.[16,17,18] One study found DMAE useful in helping learning disabled children.[19] A handful of other studies on rodents have shown that it has beneficial effects on memory.[20,21]
Any nootropic effects derived from ginkgo biloba comes from the plant's leaves.
Much of the research surrounding the ginkgo biloba herb is based on a standardized extract derived from the ginkgo leaf.
Ginkgo biloba is one of the best selling herbal supplements is in Europe and the United States. Traditionally, it has been used to improve memory and treat blood disorders. These benefits have been confirmed, to some degree, in modern studies.[22]
Some scientific literature claims that ginkgo biloba may have the potential to enhance mental function in younger people.[23] There is even more evidence that it can provide some amount of relief to individuals suffering from Alzheimer's.[24,25,26]
Ginseng is a highly sought after and extremely expensive medicinal herb. The root is the part most commonly used. Ginseng must be cultivated for at least five years before being harvested. Because of this, top quality roots can sell for upwards of $10,000.
There are three different plants referred to as ginseng:
*Siberian ginseng is not actually related to ginseng at all, it is commonly known as eleuthero.
When panax ginseng is heat dried, it is considered red ginseng. When it is dried naturally, it is called white ginseng. In Traditional Chinese Medicine (TCM) both versions of panax have unique benefits.[27,28,29,30] American and panax ginseng are rich in a saponin called ginsenoside, which has been used effectively to protect against neuronal damage that impairs learning and memory.[31,32] A double blind, placebo-controlled study found that red panax ginseng was effective at improving cognitive function.[33]
Huperzine A is a potent compound that belongs to the same class of chemicals as caffeine and cocaine, known as alkaloids. It is sold over the counter as a brain booster because of its potential for enhancing mental function. Studies have suggested that it may improve memory, and it is commonly used to treat Alzheimer's disease and other similar conditions.[34,35,36]
Idebenone, a synthetic analogue of CoQ10, is a powerful antioxidant that may protect against nerve damage in the central nervous system (CNS). This compound has been studied for its neuroprotective properties and has been considered effective against age-related cognitive disorders.[37-41]
Inositol, unofficially known as vitamin B8, is a naturally occuring isomer of glucose. High concentrations of inositol are found in heart and brain tissue. It plays important roles in a number of regulatory mechanisms in the body, especially in relation to muscle and nerve tissue. It's also key to proper functioning of cell membranes.
Inositol is present in food in three forms:
Inositol is sometimes recommended for Alzheimer's disease, obsessive compulsive disorder (OCD), attention deficit disorder (ADD), depression, and bipolar disorder.[42-45] Additionally, some studies on animals demonstrate possible memory related cognitive benefits.[46,47]
NADH is considered to be a vitamin B3 co-enzyme.[48] Research suggests that it might be effective at preserving, and even enhancing, cognitive function.[49] It also appears to play major roles in longevity and several age-associated diseases, including neurodegenerative disease.[50] Additionally, there is some evidence supporting its potentially protective effects against a broad range of cognitive disorders, including stroke and Alzheimer's disease.[51,52,53] Deficiency in NADH has been linked directly to the disease pellagra.[54] There is also some proof that it may be helpful in treating chronic fatigue syndrome.[55]
SNS Nutrition's Phenibut-XT promotes relaxation and is known for its nootropic effects.
Phenibut is classified as a neuropsychotropic drug that offers nootropic effects. In Russia, it is widely used to relieve tension, anxiety, depression, post traumatic stress, stuttering, and fear. It has also been used to improve sleep in some patients.[57]
The nootropic effects of phenibut have further been backed by animal studies, especially in regards to memory and learning.[57,58]
Phosphatidylserine belongs to the class of chemical compounds known as phospholipids. It's an essential component in all cells, specifically, the cell membrane (the "skin" of the cell). Research suggests that phosphatidylserine may be helpful in treating declining mental function and depression in the elderly.[59-63]
Also known as nicotinoyl-GABA, or pikamilon, picamilon has been shown to restore GABA receptors in rat brains.[65]
Picamilon appears to have a high bioavailability, and it is able to cross the blood-brain barrier.[66] One study on rats demonstrated potential benefits on short-term memory and learning.[67] It is speculated that some of the benefits attributed to picamilon might be linked with its ability to increase blood supply to the brain.[68]
PQQ, also known as methoxatin, was first recognized as an enzyme co-factor in methylotropic bacteria. There are some reported benefits from PQQ supplementation related to immune, antioxidant, and cognitive functions.[69] PQQ has also been shown to increase nerve growth factor and protect against neurodegeneration.[70-72]
Schisandra is a fruiting vine native to eastern Asia. The small red berries produced by this infamous medicinal herb contain a lignan called schizandrin.[85,86] which has been fairly well studied for its possible mental health benefits. It's speculated that schizandrin's cognitive-enhancing potential could be due to its powerful antioxidant and neuroprotective properties.[87-92]
Vinpocetine is an alkaloid that provides very promising neuroprotective effects. It has been regarded as a full-fledged nootropic because of its ability to improve both short and long-term memory, and increases alertness. It is suspected that vinpocetine acts as a cognitive enhancer through a number of mechanisms. One of the most prominent is its ability to enhance blood flow to the brain.[94-98] One study even described it as "Viagra for the brain."[95]
Adequate amounts of key vitamins and minerals are critical for supporting proper brain function, specifically cognition. Additionally, nutritional deficits may greatly impair mental performance.[99] Vitamin K, in particular, has been gaining attention for it's potential role in brain health and cognition.[100,101]
Fish oil is rich in essential fatty acids (EFAs). Scientific literature acknowledges the fact that EFAs play an important role in brain health. The body cannot produce essential fatty acids on its own, they must be consumed through diet and/or supplementation.[102,103]
Pro athletes are not permitted to use adrafinil.
Adrafinil is considered a "pro-drug" to modafinil, which is only available by prescription. In other words, adrafinil is metabolized (converted by the body) into modafinil.
Both of these compounds are metabolized into modafinilic acid. Adrafinil is relatively understudied, but because both convert into the same active component, studies done on modafinil are commonly cited for adrafinil.[3,4]
These studies provide evidence supporting the pro-cognitive effects of modafinil and describe it as a psychostimulant.[5] One study was able to demonstrate that modafinil, combined with cognitive training, greatly enhanced learning capability in healthy volunteers.[6] Another study established that modafinil has definite cognitive-enhancing properties in young, healthy individuals.[7] Despite being classified as a legal substance, in 2004, the World Anti-Doping Agency (WADA) banned athletes from using adrafinil.[4]
There is a wealth of evidence demonstrating ALCAR's positive effects on brain function and cognition. Many of these benefits have been associated with its neuroprotective, antioxidant qualities and its ability to enhance the production of adenosine triphosphate (ATP).[104, 105, 106, 107, 108, 109, 110]
Some nootropics, when taken at doses higher than the tolerable upper intake level (UL), can cause minor side effects, such as diarrhea, headache, nausea, and digestive discomfort. Even when there is no UL, there's still a chance that you may experience adverse effects.
You should know that not all nootropics have been studied adequately in regards to their long term safety. In order to minimize the chances of experiencing side effects, you should always use supplements responsibly, making sure you read the label and use the product as instructed. Also, talk to your health care provider before starting any new type of supplementation or fitness regimen.
Many of the studies done regarding the efficacy of nootropics were done with specific clinical applications in mind. While some studies were conducted using healthy volunteers, a bulk of them were on subjects that were suffering with cognitive disorders of various types and degrees. This makes it unclear as to how nootropics might affect the general population.
Building your supplement regimen around a sound diet is of the utmost importance. Studies validate the impact that diet has on cognitive function.[124] Whole food sources should always be your go-to choice when available and substituting supplements for whole food is not advisable.
Make PricePlow your number-one source for all things health and fitness. We make it easy and convenient to compare prices on your favorite supplements. Also, you will find honest, third-party reviews and free product guides that are packed with thoroughly researched and up-to-date information.
See the rest here:
Nootropics: Cognitive Brain Enhancers to get Focused
- Brain Center - Research News and brain Supplement Reviews - December 12th, 2016 [December 12th, 2016]
- Buy Noopept Powder | View Noopept Reviews and Benefits - December 14th, 2016 [December 14th, 2016]
- Racetam - Wikipedia - December 15th, 2016 [December 15th, 2016]
- Nootropics from Nature - niume.com - December 17th, 2016 [December 17th, 2016]
- Nootrobox - Official Site - December 18th, 2016 [December 18th, 2016]
- What Are Nootropics? A Guide to Nootropic Supplements - December 26th, 2016 [December 26th, 2016]
- Nootropic Supplements [Smart Drugs] Simple Nootropics Guide - December 27th, 2016 [December 27th, 2016]
- 13 Nootropics to Unlock Your True Brain - blog.bulletproof.com - January 3rd, 2017 [January 3rd, 2017]
- Nootropics | The Biohacker Guide by Nootrobox - January 3rd, 2017 [January 3rd, 2017]
- About Us - Nootropics.com - January 17th, 2017 [January 17th, 2017]
- Silicon Valley's 'nootropic' smart drugs a big business - Daily Sabah - February 7th, 2017 [February 7th, 2017]
- How to target a niche market at a small business - Telegraph.co.uk - February 8th, 2017 [February 8th, 2017]
- Global Nootropics Market has been expected to grow at CAGR 17.9% CAGR during 2016-2024- Credence Research - PDF Devices - February 14th, 2017 [February 14th, 2017]
- Onnit Earth Grown Nutrients All-In-One Daily Greens Mix Review - BarBend (blog) - February 15th, 2017 [February 15th, 2017]
- Need Some Energy Or Some Better Sleep? The Mad Scientists at Nootrobox Can Help - Magnetic Magazine (blog) - February 16th, 2017 [February 16th, 2017]
- Elevacity Introduces Smart Coffee: "Elevate" - Press Release ... - Digital Journal - February 18th, 2017 [February 18th, 2017]
- Elevacity Introduces Smart Coffee: Elevate - Satellite PR News (press release) - February 20th, 2017 [February 20th, 2017]
- The Nootropics Guy | Testing and Reviewing Nootropics - February 20th, 2017 [February 20th, 2017]
- NEU Brings Nootropics to Energy Shots - BevNET.com - February 21st, 2017 [February 21st, 2017]
- Nootropedia Launches Flagship Brain Conference | Benzinga - Benzinga - March 3rd, 2017 [March 3rd, 2017]
- Le-Vel's new premium nootropic capsule designed to support, optimize mental capabilities - Yahoo Finance - March 7th, 2017 [March 7th, 2017]
- Hacking the Human Body with the CEO of Nootrobox - Paste Magazine - March 7th, 2017 [March 7th, 2017]
- Why Would People Without Diabetes Monitor Their Blood Sugar? - A Sweet Life - March 8th, 2017 [March 8th, 2017]
- Sharp & Energized! IMPRESS! Dietary Supplement for Men Unleashes Nootropic Power of Cereboost from Naturex - Digital Journal - April 8th, 2017 [April 8th, 2017]
- Take a Chill Pill (How to Relax in the Modern Age) - Huffington Post - April 8th, 2017 [April 8th, 2017]
- Brief Guide To Nootropic Supplements - Serie A Weekly - June 6th, 2017 [June 6th, 2017]
- Best Nootropics Smart Pills - Serie A Weekly - June 6th, 2017 [June 6th, 2017]
- How Do Various Nootropics Work? - Serie A Weekly - June 6th, 2017 [June 6th, 2017]
- Information On Nootropics - Serie A Weekly - June 12th, 2017 [June 12th, 2017]
- Best Nootropics for Sale in 2017 | Reviews and Comparison - June 20th, 2017 [June 20th, 2017]
- Nootropics Market Is Predicted To Hit USD 6059.4 Mn By 2024, Expanding At A CAGR Of 17.9% From 2016 To 2024. - Technorati - June 23rd, 2017 [June 23rd, 2017]
- The Ultimate Guide To Nootropics | Supplement Critique - June 23rd, 2017 [June 23rd, 2017]
- Medical Q&A: So-called smart drugs can turn out to be a dumb idea - Sarasota Herald-Tribune - June 27th, 2017 [June 27th, 2017]
- Duke Neuroscientist: Brain Augmentation Will Allow Us to Make a New Kind of Human - Futurism - July 3rd, 2017 [July 3rd, 2017]
- Nootrobox is now HVMN and will sell biohacking products beyond nootropics - TechCrunch - July 3rd, 2017 [July 3rd, 2017]
- The Top 5 Nootropic Supplements of 2017 Health Ranks - July 4th, 2017 [July 4th, 2017]
- NITROvit 2017 - Brain Enhancement Memory and Focus Pills - July 5th, 2017 [July 5th, 2017]
- Buying a boost: Smart drugs on campus - Emerald Media - Oregon Daily Emerald - July 15th, 2017 [July 15th, 2017]
- NETCENTS Integrates Top Tier Merchants Within the Nutraceutical Sector - Canada NewsWire (press release) - July 20th, 2017 [July 20th, 2017]
- Every Entrepreneur Needs Flow. Nootropics Can Get You There. - Entrepreneur - July 20th, 2017 [July 20th, 2017]
- Nootropics | Our Favorite Nootropics Supplements - July 20th, 2017 [July 20th, 2017]
- True Focus Review (UPDATED 2017): Don't Buy Before You Read This! - Diets In Review (blog) - July 26th, 2017 [July 26th, 2017]
- Nootropics: How Smart Can You Get on Smart Drugs? - Brain Blogger (blog) - July 26th, 2017 [July 26th, 2017]
- Is Qualia Revolutionary or Just Another Nootropic? - HuffPost - August 1st, 2017 [August 1st, 2017]
- New study into 'smart drugs' in the finance industry - Investment Magazine - August 4th, 2017 [August 4th, 2017]
- Pimp my Brain: The Quest for Intelligence - TG Daily (blog) - August 4th, 2017 [August 4th, 2017]
- Nootropic Effects of Psychedelic and Addictive Substances - Brain Blogger (blog) - August 4th, 2017 [August 4th, 2017]
- Smart drugs in financial services: A growing trend? - Professional Planner - August 7th, 2017 [August 7th, 2017]
- Labdoor Special Report: We Tested the Infowars Supplements - Markets Insider - August 11th, 2017 [August 11th, 2017]
- Could new dietary supplements boost brain power? - WNDU-TV - August 12th, 2017 [August 12th, 2017]
- NootroNerd Website Offers Comprehensive Articles About Nootropics and Cognitive Enhancement Methods - Digital Journal - August 25th, 2017 [August 25th, 2017]
- 4 Biohacking Facts You Should Know About in 2017 - Techzone360 - August 25th, 2017 [August 25th, 2017]
- Best Supplements For Your Brain: 4 Nootropics That Work Like ... - February 11th, 2018 [February 11th, 2018]
- Best Supplements For Your Brain: 4 Nootropics That Work ... - February 23rd, 2018 [February 23rd, 2018]
- nootropics / smart drugs - March 26th, 2018 [March 26th, 2018]
- NootropicsDepot - Official Site - April 3rd, 2018 [April 3rd, 2018]
- Modafy Brain Stack | Accelerated Nootropics Formula - April 29th, 2018 [April 29th, 2018]
- Noopept | Smarter Nootropics - July 6th, 2018 [July 6th, 2018]
- About - Pure Nootropics - August 19th, 2018 [August 19th, 2018]
- Buy Bulk Nootropics Online at SmartPowders.com - August 19th, 2018 [August 19th, 2018]
- Nootropics Supply | Smart Drugs & Racetams - September 6th, 2018 [September 6th, 2018]
- Ranking the best nootropics of 2018 - BodyNutrition - September 16th, 2018 [September 16th, 2018]
- What are Nootropics? - Smart Drug Smarts | Fuel Your ... - September 17th, 2018 [September 17th, 2018]
- Lithium Orotate Nootropics Expert - October 9th, 2018 [October 9th, 2018]
- Thrive Naturals Super Brain Renew Review | Brain Supplement ... - October 12th, 2018 [October 12th, 2018]
- Pure Nootropics Review - Are They Reliable? - November 3rd, 2018 [November 3rd, 2018]
- Buy the Best Nootropics in Europe - Mind Nutrition Research - November 3rd, 2018 [November 3rd, 2018]
- Top Nootropics 2018 (200% Increased Productivity) - November 3rd, 2018 [November 3rd, 2018]
- Nootropics & Smart Drug Reviews - November 3rd, 2018 [November 3rd, 2018]
- Nootroo - The Gold Standard In Nootropics - November 8th, 2018 [November 8th, 2018]
- The Complete Introduction To Nootropics, From Beginner To ... - December 11th, 2018 [December 11th, 2018]
- Best Nootropics 2018 (Updated) Nootropics Expert - January 16th, 2019 [January 16th, 2019]
- The Big List of Nootropics | Braintropic - April 6th, 2019 [April 6th, 2019]
- The Complete Introduction To Nootropics, From Beginner To Expert - April 6th, 2019 [April 6th, 2019]
- Nootropics r/Nootropics - reddit - April 6th, 2019 [April 6th, 2019]
- What are "Nootropics"? - Smart Drug Smarts - April 20th, 2019 [April 20th, 2019]
- Best Nootropics 2019 (Updated from 2018) Nootropics Expert - April 29th, 2019 [April 29th, 2019]
- What are Nootropics? | Braintropic - June 3rd, 2019 [June 3rd, 2019]
- Best Nootropics (Smart Drugs) to Unlock Your True Brain - June 3rd, 2019 [June 3rd, 2019]
- Biohacking: The Art and Science of Upgrading the Human Being - Interesting Engineering - September 21st, 2019 [September 21st, 2019]