University of Toronto researchers have discovered that an active rather than passive process dictates which nanoparticles enter solid tumours, upending decades of thinking in the field of cancer nanomedicine and pointing toward more effective nanotherapies.
The prevailing theory in cancer nanomedicine an approach that enables more targeted therapies than standard chemotherapy has been that nanoparticles mainly diffuse passively into tumours through tiny gaps between cells in the endothelium, which lines the inner wall of blood vessels that support tumour growth.
The researchers previously showed thatless than one per centof nanoparticle-based drugs typically reach their tumour targets. In the current study, they found that among nanoparticles that do penetrate tumours, more than 95 per cent pass through endothelial cells not between gaps among those cells.
Our work challenges long-held dogma in the field and suggests a completely new theory, saysAbdullah Syed, a co-lead author on the study and post-doctoral researcher in the lab ofWarren Chan, a professor at theInstitute of Biomaterials and Biomedical Engineeringand theDonnelly Centre for Cellular and Biomolecular Research.
We saw many nanoparticles enter the endothelial cells from blood vessels and exit into the tumour in various conditions. Endothelial cells appear to be crucial gatekeepers in the nanoparticle transport process.
The findings were recently published in thejournalNature Materials.
From left to right: U of T researchers Jessica Ngai, Shrey Sindhwani, Abdullah Syed and Benjamin Kingston (photo by Qin Dai)
Syed compares nanoparticles to people trying to get into popular restaurants on a busy night. Some restaurants dont require a reservation, while others have bouncers who check if patrons made reservations, he says. The bouncers are a lot more common than researchers thought, and most places only accept patrons with a reservation.
The researchers established that passive diffusion was not the mechanism of entry with multiple lines of evidence. They took over 400 images of tissue samples from animal modelsand saw few endothelial gaps relative to nanoparticles. They observed the same trend using 3D fluorescent imaging and live-animal imaging.
Similarly, they found few gaps between endothelial cells in samples from human cancer patients.
The group then devised an animal model that completely stopped the transportation of nanoparticles through endothelial cells. This allowed them to isolate the contribution of passive transport via gaps between endothelial cells, which proved to be miniscule.
The researchers posit several active mechanisms by which endothelial cells might transport nanoparticles into tumours, including binding mechanisms, intra-endothelial channels and as-yet undiscovered processes all of which they are investigating.
Meanwhile, the results have major implications for nanoparticle-based therapeutics.
These findings will change the way we think about delivering drugs to tumours using nanoparticles, saysShrey Sindhwani, also a co-lead author on the paper and an MD/PhD student in the Chan lab. A better understanding of the nanoparticle transport phenomenon will help researchers design more effective therapies.
The research included collaborators from U of Ts department of physics in the Faculty of Arts & Science, Cold Spring Harbor Laboratory In New York and the University of Ottawa. The study was funded by the Canada Research Chairs Program, Canadian Cancer Society, Natural Sciences and Engineering Research Council of Canadaand the Canadian Institutes of Health Research.
- INBRAIN Neuroelectronics receives funding to push forward the development of graphene-based implants for brain disorders - Graphene-Info - June 14th, 2020
- Nanotechnology for Healthcare Market Global Competitions and Business Outlook 2020 to 2026 - News Collective - June 14th, 2020
- Combination Therapy of Lung Cancer Using Layer-by-Layer Cisplatin Prod | DDDT - Dove Medical Press - June 14th, 2020
- Medical Biomimetics - Market Research | Recent Trends and Growth Forecast 2025 - CueReport - June 14th, 2020
- 'Laser tweezers' in nano lab used in search for drug to prevent COVID-19 replication - The Province - May 3rd, 2020
- Missouri Indian American Professor Develops Disinfecting Tunnel to Kill Viral Infections Using Silver Nano-particles - India West - May 3rd, 2020
- Triple Negative Breast Cancer Treatment Market to Grow at Stellar CAGR Double In% During the Forecast Period 2026 - Cole of Duty - May 3rd, 2020
- PDF | What Is The Impact Of COVID 19 On Nano-Silicon Dioxide Market? | Eon Market Research Analysis Report 2020 - MR Invasion - May 3rd, 2020
- What is Nanomedicine? : Center for Nanomedicine - March 31st, 2020
- Nanomedicine | medicine | Britannica - March 31st, 2020
- Nano Medicine: Meaning, Advantages and Disadvantages - March 31st, 2020
- Nanomedicine: Nanotechnology, Biology and Medicine ... - March 31st, 2020
- What Might be the Best Way to Delivery Nanoparticle Therapy for Cancer? - Genetic Engineering & Biotechnology News - March 31st, 2020
- Nano Healthcare Technology For Medical Equipment Market Business Opportunities, 2020 Trends, Challenges and Standardization, Research, Key Players and... - March 31st, 2020
- Global Healthcare Nanotechnology Market 2019 Present Status and Future Opportunities by Major Companies Typs and Applications 2024 - The Fuel Fox - March 31st, 2020
- Nanobiotix 2019 Q4 and Annual Revenues - BioSpace - February 29th, 2020
- Dying Of Flu, College Student Used Cellphone To Call 911. He Died When Police Couldn't Find His Location. - Kaiser Health News - February 29th, 2020
- Clene Nanomedicine Announces First Patient Dosed in the RESCUE-ALS Clinical Trial for the Treatment of Amyotrophic Lateral Sclerosis (ALS) with Lead... - January 25th, 2020
- Modifying ICCA with Trp-Phe-Phe to Enhance in vivo Activity and Form N | IJN - Dove Medical Press - January 25th, 2020
- Biomedical Applications of Zeolitic Nanoparticles, with an Emphasis on | IJN - Dove Medical Press - January 25th, 2020
- Nanocarriers for Stroke Therapy: Advances and Obstacles in Translating | IJN - Dove Medical Press - January 25th, 2020
- Healthcare Nanotechnology (Nanomedicine) Market Share, Size, Future Demand, Global Research, Top Leading Player, Emerging Trends and Forecast to 2015 ... - January 25th, 2020
- Advancells Group & IFC Concluded their 3-Day Workshop on Regenerative Medicine - Business Wire India - January 25th, 2020
- I asked Tanzanians about studying in China: here's what they said - The Conversation Africa - January 25th, 2020
- The Future Of Nano Medicine - January 19th, 2020
- New Approaches in Breast Cancer Therapy Through Green Nanotechnology a | IJN - Dove Medical Press - January 19th, 2020
- Controlled phage therapy hints at future alternative to antibiotics - New Atlas - January 19th, 2020
- A New Old Therapy - The UCSB Current - January 19th, 2020
- Canterbury father and son's invention will revolutionise medical treatment - Stuff.co.nz - December 28th, 2019
- Rewind 2019: A Look Back at Significant Developments in Indian Science This Year - The Weather Channel - December 27th, 2019
- Electroplating method makes conductive nanostraws for injecting into and sampling from cells - Chemical & Engineering News - December 3rd, 2019
- Protein-Protected Metal Nanoclusters That Behave Like Natural Enzymes - Advanced Science News - December 3rd, 2019
- Design and Synthesis of Gold-Gadolinium-Core-Shell Nanoparticles as Co | IJN - Dove Medical Press - December 3rd, 2019
- Biochips Technologies, Companies, Applications & Markets, 2028 - 94 Companies are Included Along with a Listing of 121 Collaborations Between... - December 3rd, 2019
- Invicro LLC Joins Accenture's INTIENT Network to Help Advance Innovation in Drug Discovery and Scientific Research - BioSpace - December 3rd, 2019
- Nanoparticle therapy shows promise for treatment of rare cancer - The Brown Daily Herald - November 22nd, 2019
- At 9.6% CAGR, Healthcare Nanotechnology Market Global Industry to Reach Valuation over 306100 Million USD by 2025 - Markets Gazette 24 - November 22nd, 2019
- Nanotherapies for Rheumatoid Arthritis: Advantages, Challenges, and Future Direction - Rheumatology Advisor - November 22nd, 2019
- World Pancreatic Cancer Day: increasing awareness and inspiring action - UNSW Newsroom - November 22nd, 2019
- Bankrupt biopharmas are rare. 2019 has some worried that's changing. - BioPharma Dive - November 22nd, 2019
- Healthcare Nanotechnology Market Needs and Demand Analysis 2019 to 2025 - The Chicago Sentinel - November 13th, 2019
- Medical equipment to be infection-free now, says study - Zee News - November 12th, 2019
- Advances in nanomedicine for the treatment of ankylosing spondylitis | IJN - Dove Medical Press - November 1st, 2019
- Market Share in Nanotechnology and Nanomedicine for Treatment of Viral Infections Could Reach Tens of Billion Dollars - P&T Community - November 1st, 2019
- A highly biocompatible and intravenous injectable hafnium oxide nanocrystal synthesized to enhance radiaotherapy efficacy for cancer treatment -... - November 1st, 2019
- Doheny and UCLA Stein Eye Institutes Welcome Kaustabh Ghosh, PhD, to the Scientific and Clinical Research Faculty - PRNewswire - November 1st, 2019
- SUNY Potsdam chemistry professor awarded grant from National Institutes of Health - NNY360 - October 1st, 2019
- Improving 131I Radioiodine Therapy By Hybrid Polymer-Grafted Gold Nano | IJN - Dove Medical Press - October 1st, 2019
- MagForce AG to host Lunch Symposium on Local Therapies in Malignant Gliomas during the 19th European Congress of Neurosurgery (EANS2019) - BioSpace - October 1st, 2019
- Synthetic networks with tunable responsiveness, biodegradation, and molecular recognition for precision medicine applications - Science Advances - October 1st, 2019
- Self-Assembly Of Retinoid Nanoparticles For Melanoma Therapy | IJN - Dove Medical Press - October 1st, 2019
- Nanomanipulator Market Upcoming Trends, Revenue, Key Manufactures and Competitive Analysis till 2025 - One Digi Click - October 1st, 2019
- First-of-its-kind trial in ALS spurs hope for brutal disease - BioPharma Dive - October 1st, 2019
- FBI Investigation Targets Trump Booster Peter Thiel’s VC Firm - September 14th, 2019
- YouTube Influencers Are Mentally Collapsing From Stress - September 14th, 2019
- Watch SpaceX Test Its Crew Dragon’s Escape System - September 14th, 2019
- MIT Team “Accidentally” Invents Blackest Material in Existence - September 14th, 2019
- A Driver Tricked Uber’s Algorithm, Sexually Assaulted a Passenger - September 14th, 2019
- Toyota Wants to Slather Solar Panels All Over Its Prius Hybrid - September 14th, 2019
- A Runaway Star Is Escaping a Black Hole at 1.2 Million MPH - September 14th, 2019
- Putin Critic Uses Drone to Save Hard Drives Before Police Raid - September 14th, 2019
- Airbus Planes Will Track How Often Passengers Go to the Bathroom - September 14th, 2019
- Watch a Robot Fish Fly by Shooting Water out of Its Rear - September 14th, 2019
- Residents Are Trying to Flee Russian Town Where Snow Turned Black - September 14th, 2019
- This Startup Will Send DNA From Your Spit to the Moon for $99 - September 14th, 2019
- Horrifying Study: Corpses Thrash Around For a Year After Death - September 14th, 2019
- French Gov Official Warns Facebook: Libra Is Not Welcome Here - September 14th, 2019
- Watch a Tesla Model X Blast Through Deep Flood Waters - September 14th, 2019
- Milky Way’s Giant Black Hole Lets out Two Giant, Radioactive Burps - September 14th, 2019
- Instagram Keeps Accidentally Flagging Fish Photos as Offensive - September 14th, 2019
- MIT Community Horrified by Famed Researcher’s Epstein Outburst - September 14th, 2019
- Unlike MIT, Harvard Cut Off Epstein Donations After Conviction - September 14th, 2019
- Can You Tell Which of These Models Is CGI? - May 28th, 2019
- We Asked an AI to Finish Real Elon Musk Tweets - May 28th, 2019
- Watch a Super-Strong Robot Dog Pull a Three-Ton Airplane - May 28th, 2019
- Asteroid Flying by Earth Is so Big It Has Its Own Moon - May 28th, 2019
- United Nations: Siri and Alexa Are Encouraging Misogyny - May 28th, 2019
- New Law Could End Robocalling Once and For All - May 28th, 2019
- Scientists Set New Temperature Record for Superconductivity - May 28th, 2019
- Elevate Your Leadership and Grow Your Business at Your Clouds Can 2019 - May 28th, 2019