The fight against drug-resistant pathogens remains an intense one. While the Centers for Disease Controls (CDC) 2019 biggest threats report reveals an overall decrease in drug-resistant microbe-related deaths as compared to its previous report (2013) the agency also cautions that new forms of drug-resistant pathogens are still emerging.
Meanwhile, the options for treating infections by these germs are diminishing, confirming doctors and scientists worries about the end of the age of antibiotics.
We knew it was going to be a problem early on, said UC Santa Barbara chemistry and biochemistry professor Irene Chen. Basically as soon as penicillin was discovered, a few years later it was reported that there was a resistant organism. Thanks to factors such as horizontal gene transfer and rapid reproduction, organisms such as Gram-negative bacteria are able to evolve faster than we can produce antibiotics to control them.
So Chen and her research group are seeking alternatives to antibiotics, in a growing effort to head off the tide of incurable bacterial infections. In their work, the group has turned to bacteriophages, a naturally occurring group of viruses that colonize on bacteria.
Thats their natural function, really, to grow on and kill bacteria, said Chen, author of a paper that appears in the Proceedings of the National Academy of Sciences. By taking advantage of the bacteriophages ability to home in on specific bacteria without damaging the rest of the microbiome, the researchers were able to use a combination of gold nanorods and near-infrared light to destroy even multidrug-resistant bacteria without antibiotics.
Phage therapy isnt new, Chen said. In fact, it has been used in the former Soviet Union and Europe for about a century, though they are seen largely as last-resort alternatives to antibiotics. Among the unresolved issues of phage therapy is the incomplete characterization of the phages biology a biology that could allow for unintended consequences due to the phages own rapid evolution and reproduction, as well as potential toxins the viruses may carry. Another issue is the all-or-nothing aspect of phage therapy, Chen added.
Its difficult to analyze the effect of a phage treatment, she said. You might see it completely work or you might see it completely fail, but you dont have the kind of dose response you want.
To surmount these challenges, the Chen lab developed a method of controlled phage therapy.
What we did was to conjugate the phages to gold nanorods, she explained. These phanorods were applied to bacteria on in-vitro cultures of mammalian cells and then exposed to near-infrared light.
Conjugated to phages,gold nanorods find their target: a bacterial cell wall
Photo Credit: COURTESY IMAGE
When these nanorods are photo-excited, they translate the energy from light to heat, Chen said, and that creates very high local temperatures.
The heat is enough to kill the bacteria, and it also kills the phages, preventing any unwanted further evolutions. The result is a guided missile of targeted phage therapy that also allows for dosage control. The lab found success in destroying E. coli, P. aeruginosa and V. cholerae human pathogens that cause acute symptoms if left unchecked. They also were able to successfully destroy X. campestris, a bacteria that causes rot in plants.
In a collaboration with UC Santa Barbara mechanical engineer Beth Pruitt, the lab determined that while the heat successfully destroyed bacteria and phage, more than 80% of the mammalian cell culture underneath the bacteria biofilm survived.
Bacteria under fire: Green bacteria are alive, while the red ones are dead
Photo Credit: COURTESY IMAGE
This issue of whether it damages mammalian tissues is very important, Chen said. Work in nanotechnology and nanomedicine treating bacterial infections indicates that when its non-targeted, it really does burden the surrounding tissues.
The lab plans to investigate other possible phages to counter other bacteria, possibly engineering a photothermal method that could treat multiple bacterial infections.
Research on this study was conducted also by UCSB postdoctoral fellow Huan Peng (lead author), Raymond E. Borg and Liam P. Dow.
Read the original post:
- INBRAIN Neuroelectronics receives funding to push forward the development of graphene-based implants for brain disorders - Graphene-Info - June 14th, 2020
- Nanotechnology for Healthcare Market Global Competitions and Business Outlook 2020 to 2026 - News Collective - June 14th, 2020
- Combination Therapy of Lung Cancer Using Layer-by-Layer Cisplatin Prod | DDDT - Dove Medical Press - June 14th, 2020
- Medical Biomimetics - Market Research | Recent Trends and Growth Forecast 2025 - CueReport - June 14th, 2020
- 'Laser tweezers' in nano lab used in search for drug to prevent COVID-19 replication - The Province - May 3rd, 2020
- Missouri Indian American Professor Develops Disinfecting Tunnel to Kill Viral Infections Using Silver Nano-particles - India West - May 3rd, 2020
- Triple Negative Breast Cancer Treatment Market to Grow at Stellar CAGR Double In% During the Forecast Period 2026 - Cole of Duty - May 3rd, 2020
- PDF | What Is The Impact Of COVID 19 On Nano-Silicon Dioxide Market? | Eon Market Research Analysis Report 2020 - MR Invasion - May 3rd, 2020
- What is Nanomedicine? : Center for Nanomedicine - March 31st, 2020
- Nanomedicine | medicine | Britannica - March 31st, 2020
- Nano Medicine: Meaning, Advantages and Disadvantages - March 31st, 2020
- Nanomedicine: Nanotechnology, Biology and Medicine ... - March 31st, 2020
- What Might be the Best Way to Delivery Nanoparticle Therapy for Cancer? - Genetic Engineering & Biotechnology News - March 31st, 2020
- Nano Healthcare Technology For Medical Equipment Market Business Opportunities, 2020 Trends, Challenges and Standardization, Research, Key Players and... - March 31st, 2020
- Global Healthcare Nanotechnology Market 2019 Present Status and Future Opportunities by Major Companies Typs and Applications 2024 - The Fuel Fox - March 31st, 2020
- Nanobiotix 2019 Q4 and Annual Revenues - BioSpace - February 29th, 2020
- Dying Of Flu, College Student Used Cellphone To Call 911. He Died When Police Couldn't Find His Location. - Kaiser Health News - February 29th, 2020
- Clene Nanomedicine Announces First Patient Dosed in the RESCUE-ALS Clinical Trial for the Treatment of Amyotrophic Lateral Sclerosis (ALS) with Lead... - January 25th, 2020
- Modifying ICCA with Trp-Phe-Phe to Enhance in vivo Activity and Form N | IJN - Dove Medical Press - January 25th, 2020
- Biomedical Applications of Zeolitic Nanoparticles, with an Emphasis on | IJN - Dove Medical Press - January 25th, 2020
- Nanocarriers for Stroke Therapy: Advances and Obstacles in Translating | IJN - Dove Medical Press - January 25th, 2020
- Healthcare Nanotechnology (Nanomedicine) Market Share, Size, Future Demand, Global Research, Top Leading Player, Emerging Trends and Forecast to 2015 ... - January 25th, 2020
- Advancells Group & IFC Concluded their 3-Day Workshop on Regenerative Medicine - Business Wire India - January 25th, 2020
- I asked Tanzanians about studying in China: here's what they said - The Conversation Africa - January 25th, 2020
- The Future Of Nano Medicine - January 19th, 2020
- New Approaches in Breast Cancer Therapy Through Green Nanotechnology a | IJN - Dove Medical Press - January 19th, 2020
- Controlled phage therapy hints at future alternative to antibiotics - New Atlas - January 19th, 2020
- Most engineered nanoparticles enter tumours through cells not between them, U of T researchers find - News@UofT - January 19th, 2020
- Canterbury father and son's invention will revolutionise medical treatment - Stuff.co.nz - December 28th, 2019
- Rewind 2019: A Look Back at Significant Developments in Indian Science This Year - The Weather Channel - December 27th, 2019
- Electroplating method makes conductive nanostraws for injecting into and sampling from cells - Chemical & Engineering News - December 3rd, 2019
- Protein-Protected Metal Nanoclusters That Behave Like Natural Enzymes - Advanced Science News - December 3rd, 2019
- Design and Synthesis of Gold-Gadolinium-Core-Shell Nanoparticles as Co | IJN - Dove Medical Press - December 3rd, 2019
- Biochips Technologies, Companies, Applications & Markets, 2028 - 94 Companies are Included Along with a Listing of 121 Collaborations Between... - December 3rd, 2019
- Invicro LLC Joins Accenture's INTIENT Network to Help Advance Innovation in Drug Discovery and Scientific Research - BioSpace - December 3rd, 2019
- Nanoparticle therapy shows promise for treatment of rare cancer - The Brown Daily Herald - November 22nd, 2019
- At 9.6% CAGR, Healthcare Nanotechnology Market Global Industry to Reach Valuation over 306100 Million USD by 2025 - Markets Gazette 24 - November 22nd, 2019
- Nanotherapies for Rheumatoid Arthritis: Advantages, Challenges, and Future Direction - Rheumatology Advisor - November 22nd, 2019
- World Pancreatic Cancer Day: increasing awareness and inspiring action - UNSW Newsroom - November 22nd, 2019
- Bankrupt biopharmas are rare. 2019 has some worried that's changing. - BioPharma Dive - November 22nd, 2019
- Healthcare Nanotechnology Market Needs and Demand Analysis 2019 to 2025 - The Chicago Sentinel - November 13th, 2019
- Medical equipment to be infection-free now, says study - Zee News - November 12th, 2019
- Advances in nanomedicine for the treatment of ankylosing spondylitis | IJN - Dove Medical Press - November 1st, 2019
- Market Share in Nanotechnology and Nanomedicine for Treatment of Viral Infections Could Reach Tens of Billion Dollars - P&T Community - November 1st, 2019
- A highly biocompatible and intravenous injectable hafnium oxide nanocrystal synthesized to enhance radiaotherapy efficacy for cancer treatment -... - November 1st, 2019
- Doheny and UCLA Stein Eye Institutes Welcome Kaustabh Ghosh, PhD, to the Scientific and Clinical Research Faculty - PRNewswire - November 1st, 2019
- SUNY Potsdam chemistry professor awarded grant from National Institutes of Health - NNY360 - October 1st, 2019
- Improving 131I Radioiodine Therapy By Hybrid Polymer-Grafted Gold Nano | IJN - Dove Medical Press - October 1st, 2019
- MagForce AG to host Lunch Symposium on Local Therapies in Malignant Gliomas during the 19th European Congress of Neurosurgery (EANS2019) - BioSpace - October 1st, 2019
- Synthetic networks with tunable responsiveness, biodegradation, and molecular recognition for precision medicine applications - Science Advances - October 1st, 2019
- Self-Assembly Of Retinoid Nanoparticles For Melanoma Therapy | IJN - Dove Medical Press - October 1st, 2019
- Nanomanipulator Market Upcoming Trends, Revenue, Key Manufactures and Competitive Analysis till 2025 - One Digi Click - October 1st, 2019
- First-of-its-kind trial in ALS spurs hope for brutal disease - BioPharma Dive - October 1st, 2019
- FBI Investigation Targets Trump Booster Peter Thiel’s VC Firm - September 14th, 2019
- YouTube Influencers Are Mentally Collapsing From Stress - September 14th, 2019
- Watch SpaceX Test Its Crew Dragon’s Escape System - September 14th, 2019
- MIT Team “Accidentally” Invents Blackest Material in Existence - September 14th, 2019
- A Driver Tricked Uber’s Algorithm, Sexually Assaulted a Passenger - September 14th, 2019
- Toyota Wants to Slather Solar Panels All Over Its Prius Hybrid - September 14th, 2019
- A Runaway Star Is Escaping a Black Hole at 1.2 Million MPH - September 14th, 2019
- Putin Critic Uses Drone to Save Hard Drives Before Police Raid - September 14th, 2019
- Airbus Planes Will Track How Often Passengers Go to the Bathroom - September 14th, 2019
- Watch a Robot Fish Fly by Shooting Water out of Its Rear - September 14th, 2019
- Residents Are Trying to Flee Russian Town Where Snow Turned Black - September 14th, 2019
- This Startup Will Send DNA From Your Spit to the Moon for $99 - September 14th, 2019
- Horrifying Study: Corpses Thrash Around For a Year After Death - September 14th, 2019
- French Gov Official Warns Facebook: Libra Is Not Welcome Here - September 14th, 2019
- Watch a Tesla Model X Blast Through Deep Flood Waters - September 14th, 2019
- Milky Way’s Giant Black Hole Lets out Two Giant, Radioactive Burps - September 14th, 2019
- Instagram Keeps Accidentally Flagging Fish Photos as Offensive - September 14th, 2019
- MIT Community Horrified by Famed Researcher’s Epstein Outburst - September 14th, 2019
- Unlike MIT, Harvard Cut Off Epstein Donations After Conviction - September 14th, 2019
- Can You Tell Which of These Models Is CGI? - May 28th, 2019
- We Asked an AI to Finish Real Elon Musk Tweets - May 28th, 2019
- Watch a Super-Strong Robot Dog Pull a Three-Ton Airplane - May 28th, 2019
- Asteroid Flying by Earth Is so Big It Has Its Own Moon - May 28th, 2019
- United Nations: Siri and Alexa Are Encouraging Misogyny - May 28th, 2019
- New Law Could End Robocalling Once and For All - May 28th, 2019
- Scientists Set New Temperature Record for Superconductivity - May 28th, 2019
- Elevate Your Leadership and Grow Your Business at Your Clouds Can 2019 - May 28th, 2019