Laxmi Bhatta,1 Linda Leivseth,2 Xiao-Mei Mai,1 Anne Hildur Henriksen,3,4 David Carslake,5,6 Yue Chen,7 Arnulf Langhammer,8,* Ben Michael Brumpton4,5,9,*
1Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology, Trondheim, Norway; 2Centre for Clinical Documentation and Evaluation (SKDE), Northern Norway Regional Health Authority, Troms, Norway; 3Department of Circulation and Medical Imaging, NTNU Norwegian University of Science and Technology, Trondheim, Norway; 4Clinic of Thoracic and Occupational Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; 5Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; 6Population Health Sciences, University of Bristol, Bristol, UK; 7School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada; 8HUNT Research Centre, Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology, Levanger, Norway; 9K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology, Trondheim, Norway
*These authors contributed equally to this work
Correspondence: Laxmi BhattaDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU Norwegian University of Science and Technology, P.O. Box 8905, MTFS, Trondheim NO-7491, NorwayEmail laxmi.bhatta@ntnu.no
Purpose: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) has published three classifications of COPD from 2007 to 2017. No studies have investigated the ability of these classifications to predict COPD-related hospitalizations. We aimed to compare the discrimination ability of the GOLD 2007, 2011, and 2017 classifications to predict COPD hospitalization and all-cause mortality.Patients and Methods: We followed 1300 participants with COPD aged 40 years who participated in the HUNT Study (1995 1997) through to December 31, 2015. Survival analysis and time-dependent area under receiver operating characteristics curves (AUC) were used to compare the discrimination abilities of the GOLD classifications.Results: Of the 1300 participants, 522 were hospitalized due to COPD and 896 died over 20.4 years of follow-up. In adjusted models, worsening GOLD 2007, GOLD 2011, or GOLD 2017 categories were associated with higher hazards for COPD hospitalization and all-cause mortality, except for the GOLD 2017 classification and all-cause mortality (ptrend=0.114). In crude models, the AUCs (95% CI) for the GOLD 2007, GOLD 2011, and GOLD 2017 for COPD hospitalization were 63.1 (58.7 66.9), 60.9 (56.1 64.4), and 56.1 (54.0 58.1), respectively, at 20-years follow-up. Corresponding estimates for all-cause mortality were 57.0 (54.8 59.1), 54.1 (52.1 56.0), and 52.6 (51.0 54.3). The differences in AUCs between the GOLD classifications to predict COPD hospitalization and all-cause mortality were constant over the follow-up time.Conclusion: The GOLD 2007 classification was better than the GOLD 2011 and 2017 classifications at predicting COPD hospitalization and all-cause mortality.
Keywords: GOLD grades, ABCD groups, COPD hospitalization, mortality, area under curve, AUC
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.
Read the original post:
GOLD Classifications, COPD Hospitalization, and All-Cause Mortality in | COPD - Dove Medical Press
- "Shift Happens" - November 8th, 2009 [November 8th, 2009]
- Getting Started With Your Personal Statement - November 8th, 2009 [November 8th, 2009]
- I started this blog 1 year ago. I'm ready to become a medical doctor. - November 8th, 2009 [November 8th, 2009]
- Poll Results: "What is your GPA?" - November 8th, 2009 [November 8th, 2009]
- Why Ross University School of Medicine? - November 8th, 2009 [November 8th, 2009]
- Why Ross University? (Continued) - November 8th, 2009 [November 8th, 2009]
- Filling out applications with the last 4 years in mind. - November 8th, 2009 [November 8th, 2009]
- "Active and Passive Euthanasia" - November 8th, 2009 [November 8th, 2009]
- 300 Word Personal Statement - First Draft - November 8th, 2009 [November 8th, 2009]
- 300 Word Personal Statement - 2nd Draft - November 8th, 2009 [November 8th, 2009]
- "Where did you do EMT training at?" - November 8th, 2009 [November 8th, 2009]
- "is this jonathan that went to brazil in the summer of 2006?" - November 8th, 2009 [November 8th, 2009]
- First Application is Away - Ross University - November 8th, 2009 [November 8th, 2009]
- AMCAS—The American Medical College Application Service - November 8th, 2009 [November 8th, 2009]
- The Student Doctor Network - November 8th, 2009 [November 8th, 2009]
- Crime Incident - Public Safety Announcement: STUDENTS - November 8th, 2009 [November 8th, 2009]
- AMCAS Deadlines & Delays - Answered - November 8th, 2009 [November 8th, 2009]
- Headstart on Secondary Applications - The Student Doctor Network - November 8th, 2009 [November 8th, 2009]
- The Complete Medical School & Admissions Guide - Revisited - November 8th, 2009 [November 8th, 2009]
- Interview Status - Ross University - November 8th, 2009 [November 8th, 2009]
- Finished my first interview. - November 8th, 2009 [November 8th, 2009]
- "You have a 95% chance of acceptance..." - November 8th, 2009 [November 8th, 2009]
- "I was just wondering if I have to go to medical school i will have to start college allover again." - November 8th, 2009 [November 8th, 2009]
- Interview Feedback - Allopathic Medical Schools - Ross University School of Medicine (Dominica Caribbean) - November 8th, 2009 [November 8th, 2009]
- ACCEPTED! - November 8th, 2009 [November 8th, 2009]
- Step 1 Revisited - November 8th, 2009 [November 8th, 2009]
- A Few More Thoughts On Moving - November 8th, 2009 [November 8th, 2009]
- Update - November 8th, 2009 [November 8th, 2009]
- Closing In - November 8th, 2009 [November 8th, 2009]
- Internet/Computer Hell - November 8th, 2009 [November 8th, 2009]
- Back On The Net - November 8th, 2009 [November 8th, 2009]
- 1 More Day - November 8th, 2009 [November 8th, 2009]
- Loan Deferment Blog - November 8th, 2009 [November 8th, 2009]
- Graduated! - November 8th, 2009 [November 8th, 2009]
- What Happened? - November 8th, 2009 [November 8th, 2009]
- Interesting Case - November 8th, 2009 [November 8th, 2009]
- What Made Me Stupid? - November 8th, 2009 [November 8th, 2009]
- Blah. - November 8th, 2009 [November 8th, 2009]
- Call - November 8th, 2009 [November 8th, 2009]
- Medicine in the Media - November 8th, 2009 [November 8th, 2009]
- Was Medical School Worth It? - November 8th, 2009 [November 8th, 2009]
- Off I Go... - November 8th, 2009 [November 8th, 2009]
- Is It Worth It, Part 2 - November 8th, 2009 [November 8th, 2009]
- Oriented - November 8th, 2009 [November 8th, 2009]
- GLBT in Medical School - November 8th, 2009 [November 8th, 2009]
- GLBT in Residency Applications - November 8th, 2009 [November 8th, 2009]
- I Survived - November 8th, 2009 [November 8th, 2009]
- Reflections on the First Week - November 8th, 2009 [November 8th, 2009]
- All Good Things Must End - November 8th, 2009 [November 8th, 2009]
- The Lone Coyote is Back - November 8th, 2009 [November 8th, 2009]
- Pre-med student switches gears to teach in Chicago school - Chicago Tribune - March 8th, 2010 [March 8th, 2010]
- Old-school barbecue coming to spot near Fort Worth medical district - Fort Worth Star Telegram - March 8th, 2010 [March 8th, 2010]
- Nursing home drug use puts many at risk - Boston Globe - March 8th, 2010 [March 8th, 2010]
- Dr. Anita Figueredo, first female surgeon in San Diego, dies at 93 - Los Angeles Times - March 8th, 2010 [March 8th, 2010]
- Stimulus funds pay for monkey research in NC - MiamiHerald.com - March 8th, 2010 [March 8th, 2010]
- Medicine as an economic engine - Buffalo News - March 8th, 2010 [March 8th, 2010]
- UM medical school feels the squeeze - MiamiHerald.com - March 8th, 2010 [March 8th, 2010]
- HARVARD MEDICAL SCHOOL ADVISER Bell's palsy not as serious as it appears - Detroit Free Press - March 8th, 2010 [March 8th, 2010]
- Baylor medical school works to get back on track - Houston Chronicle - March 8th, 2010 [March 8th, 2010]
- From community college to Amherst College and Yale Medical School - WalletPop (blog) - March 8th, 2010 [March 8th, 2010]
- Man questions merit of coke monkey study - UPI.com - March 8th, 2010 [March 8th, 2010]
- School Board has questions it wants answered about onsite medical clinic - Terre Haute Tribune Star - March 9th, 2010 [March 9th, 2010]
- Stimulus Funds Pay for Monkey Research - NewsMax.com - March 9th, 2010 [March 9th, 2010]
- Babylon schools head: Teen's collapse unrelated to athletics - Newsday (subscription) - March 9th, 2010 [March 9th, 2010]
- Cost Of Medical School Rises In Recession - NPR - March 9th, 2010 [March 9th, 2010]
- Flu Shots in Children Help People of All Ages - New York Times - March 9th, 2010 [March 9th, 2010]
- A prescription for improving science education - Scope (blog) - March 9th, 2010 [March 9th, 2010]
- Live kidney donors do not die sooner: study - Reuters - March 9th, 2010 [March 9th, 2010]
- UW football player suspended after alleged assault - Seattle Post Intelligencer - March 10th, 2010 [March 10th, 2010]
- More Comparative Studies Needed to Guide Physicians Study finds less than a ... - ModernMedicine - March 10th, 2010 [March 10th, 2010]
- Conservationists worry about Mo. med school plan - KOAM-TV - March 10th, 2010 [March 10th, 2010]
- Dr. William D. Lynn - Baltimore Sun - March 10th, 2010 [March 10th, 2010]
- Suspect in North Dallas shootings became reclusive after parents died, family says - Dallas Morning News - March 10th, 2010 [March 10th, 2010]
- Drinkers Gain Less Weight - Harvard Crimson - March 10th, 2010 [March 10th, 2010]
- Long-Term Health Risks Low for Kidney Donors - WebMD - March 10th, 2010 [March 10th, 2010]
- School resource officer remains in critical condition - Middletown Journal - March 10th, 2010 [March 10th, 2010]
- New Lucian Leape Institute Report Finds That U.S. Medical Schools Are Falling ... - PR Newswire (press release) - March 10th, 2010 [March 10th, 2010]
- Dual degrees program expands for Mayo Medical School students - Post-Bulletin - March 10th, 2010 [March 10th, 2010]
- Comparative Effectiveness Research is a Must - TopNews United States - March 10th, 2010 [March 10th, 2010]
- Long Beach OKs medical pot ordinance - Contra Costa Times - March 10th, 2010 [March 10th, 2010]