Medical researchers in Coventry have discovered a new treatment that could prevent the deaths of thousands of women in the developing world due to heavy blood loss after childbirth.
Postpartum haemorrhage (PPH) happens when the uterus fails to contract properly after childbirth and the mother loses 500mls or more of blood in the 24 hours after delivery.
PPH is responsible for maternal death in 1 in 1,000 deliveries in the developing world and, according to recent figures, PPH also complicates around 10 per cent of all births in England and Wales.
The research team, led by Warwick Medical School in Coventry, has identified a new drug target called Kir7.1, which when restrained induces an acute and sustained uterine contraction that could help treat cases of PPH. Their findings have been published in the journal EMBO Molecular Medicine.
Lead author Dr Andrew Blanks, associate professor in reproductive health at Warwick Medical School, says the discovery is significant because there are currently no drugs available that are effective at treating PPH.
He said: Often when a woman has been in labour for a long time, the uterus becomes exhausted and cannot contract as quickly as it should after delivery.
"Our treatment works via a separate mechanism of action to the drugs, oxytocics, that are currently used to induce labour.
"It bypasses the biochemical pathways which become exhausted and desensitised during a prolonged labour, we have demonstrated in principle that it should be more effective.
The research team, which included colleagues from Washington University, Vanderbilt University School of Medicine, Newcastle University, and University of Edinburgh, worked with Medical Research Council Technology to develop drugs to the new target.
View post:
Coventry medical researchers develop new treatment to prevent birth-related deaths
- "Shift Happens" - November 8th, 2009 [November 8th, 2009]
- Getting Started With Your Personal Statement - November 8th, 2009 [November 8th, 2009]
- I started this blog 1 year ago. I'm ready to become a medical doctor. - November 8th, 2009 [November 8th, 2009]
- Poll Results: "What is your GPA?" - November 8th, 2009 [November 8th, 2009]
- Why Ross University School of Medicine? - November 8th, 2009 [November 8th, 2009]
- Why Ross University? (Continued) - November 8th, 2009 [November 8th, 2009]
- Filling out applications with the last 4 years in mind. - November 8th, 2009 [November 8th, 2009]
- "Active and Passive Euthanasia" - November 8th, 2009 [November 8th, 2009]
- 300 Word Personal Statement - First Draft - November 8th, 2009 [November 8th, 2009]
- 300 Word Personal Statement - 2nd Draft - November 8th, 2009 [November 8th, 2009]
- "Where did you do EMT training at?" - November 8th, 2009 [November 8th, 2009]
- "is this jonathan that went to brazil in the summer of 2006?" - November 8th, 2009 [November 8th, 2009]
- First Application is Away - Ross University - November 8th, 2009 [November 8th, 2009]
- AMCAS—The American Medical College Application Service - November 8th, 2009 [November 8th, 2009]
- The Student Doctor Network - November 8th, 2009 [November 8th, 2009]
- Crime Incident - Public Safety Announcement: STUDENTS - November 8th, 2009 [November 8th, 2009]
- AMCAS Deadlines & Delays - Answered - November 8th, 2009 [November 8th, 2009]
- Headstart on Secondary Applications - The Student Doctor Network - November 8th, 2009 [November 8th, 2009]
- The Complete Medical School & Admissions Guide - Revisited - November 8th, 2009 [November 8th, 2009]
- Interview Status - Ross University - November 8th, 2009 [November 8th, 2009]
- Finished my first interview. - November 8th, 2009 [November 8th, 2009]
- "You have a 95% chance of acceptance..." - November 8th, 2009 [November 8th, 2009]
- "I was just wondering if I have to go to medical school i will have to start college allover again." - November 8th, 2009 [November 8th, 2009]
- Interview Feedback - Allopathic Medical Schools - Ross University School of Medicine (Dominica Caribbean) - November 8th, 2009 [November 8th, 2009]
- ACCEPTED! - November 8th, 2009 [November 8th, 2009]
- Step 1 Revisited - November 8th, 2009 [November 8th, 2009]
- A Few More Thoughts On Moving - November 8th, 2009 [November 8th, 2009]
- Update - November 8th, 2009 [November 8th, 2009]
- Closing In - November 8th, 2009 [November 8th, 2009]
- Internet/Computer Hell - November 8th, 2009 [November 8th, 2009]
- Back On The Net - November 8th, 2009 [November 8th, 2009]
- 1 More Day - November 8th, 2009 [November 8th, 2009]
- Loan Deferment Blog - November 8th, 2009 [November 8th, 2009]
- Graduated! - November 8th, 2009 [November 8th, 2009]
- What Happened? - November 8th, 2009 [November 8th, 2009]
- Interesting Case - November 8th, 2009 [November 8th, 2009]
- What Made Me Stupid? - November 8th, 2009 [November 8th, 2009]
- Blah. - November 8th, 2009 [November 8th, 2009]
- Call - November 8th, 2009 [November 8th, 2009]
- Medicine in the Media - November 8th, 2009 [November 8th, 2009]
- Was Medical School Worth It? - November 8th, 2009 [November 8th, 2009]
- Off I Go... - November 8th, 2009 [November 8th, 2009]
- Is It Worth It, Part 2 - November 8th, 2009 [November 8th, 2009]
- Oriented - November 8th, 2009 [November 8th, 2009]
- GLBT in Medical School - November 8th, 2009 [November 8th, 2009]
- GLBT in Residency Applications - November 8th, 2009 [November 8th, 2009]
- I Survived - November 8th, 2009 [November 8th, 2009]
- Reflections on the First Week - November 8th, 2009 [November 8th, 2009]
- All Good Things Must End - November 8th, 2009 [November 8th, 2009]
- The Lone Coyote is Back - November 8th, 2009 [November 8th, 2009]
- Pre-med student switches gears to teach in Chicago school - Chicago Tribune - March 8th, 2010 [March 8th, 2010]
- Old-school barbecue coming to spot near Fort Worth medical district - Fort Worth Star Telegram - March 8th, 2010 [March 8th, 2010]
- Nursing home drug use puts many at risk - Boston Globe - March 8th, 2010 [March 8th, 2010]
- Dr. Anita Figueredo, first female surgeon in San Diego, dies at 93 - Los Angeles Times - March 8th, 2010 [March 8th, 2010]
- Stimulus funds pay for monkey research in NC - MiamiHerald.com - March 8th, 2010 [March 8th, 2010]
- Medicine as an economic engine - Buffalo News - March 8th, 2010 [March 8th, 2010]
- UM medical school feels the squeeze - MiamiHerald.com - March 8th, 2010 [March 8th, 2010]
- HARVARD MEDICAL SCHOOL ADVISER Bell's palsy not as serious as it appears - Detroit Free Press - March 8th, 2010 [March 8th, 2010]
- Baylor medical school works to get back on track - Houston Chronicle - March 8th, 2010 [March 8th, 2010]
- From community college to Amherst College and Yale Medical School - WalletPop (blog) - March 8th, 2010 [March 8th, 2010]
- Man questions merit of coke monkey study - UPI.com - March 8th, 2010 [March 8th, 2010]
- School Board has questions it wants answered about onsite medical clinic - Terre Haute Tribune Star - March 9th, 2010 [March 9th, 2010]
- Stimulus Funds Pay for Monkey Research - NewsMax.com - March 9th, 2010 [March 9th, 2010]
- Babylon schools head: Teen's collapse unrelated to athletics - Newsday (subscription) - March 9th, 2010 [March 9th, 2010]
- Cost Of Medical School Rises In Recession - NPR - March 9th, 2010 [March 9th, 2010]
- Flu Shots in Children Help People of All Ages - New York Times - March 9th, 2010 [March 9th, 2010]
- A prescription for improving science education - Scope (blog) - March 9th, 2010 [March 9th, 2010]
- Live kidney donors do not die sooner: study - Reuters - March 9th, 2010 [March 9th, 2010]
- UW football player suspended after alleged assault - Seattle Post Intelligencer - March 10th, 2010 [March 10th, 2010]
- More Comparative Studies Needed to Guide Physicians Study finds less than a ... - ModernMedicine - March 10th, 2010 [March 10th, 2010]
- Conservationists worry about Mo. med school plan - KOAM-TV - March 10th, 2010 [March 10th, 2010]
- Dr. William D. Lynn - Baltimore Sun - March 10th, 2010 [March 10th, 2010]
- Suspect in North Dallas shootings became reclusive after parents died, family says - Dallas Morning News - March 10th, 2010 [March 10th, 2010]
- Drinkers Gain Less Weight - Harvard Crimson - March 10th, 2010 [March 10th, 2010]
- Long-Term Health Risks Low for Kidney Donors - WebMD - March 10th, 2010 [March 10th, 2010]
- School resource officer remains in critical condition - Middletown Journal - March 10th, 2010 [March 10th, 2010]
- New Lucian Leape Institute Report Finds That U.S. Medical Schools Are Falling ... - PR Newswire (press release) - March 10th, 2010 [March 10th, 2010]
- Dual degrees program expands for Mayo Medical School students - Post-Bulletin - March 10th, 2010 [March 10th, 2010]
- Comparative Effectiveness Research is a Must - TopNews United States - March 10th, 2010 [March 10th, 2010]
- Long Beach OKs medical pot ordinance - Contra Costa Times - March 10th, 2010 [March 10th, 2010]