US Ideological Distribution, 2008

Mccain2008The Pew Research Center has presented a simple linear chart that places the ideology of the three Presidential contenders and the current President on a left-right scale, along with the median ideology of the voting public. A two-axis chart would be more informative, but this one-dimensional distribution reveals a great deal :


1) The center of gravity of the US public is significantly right of the center, no matter what leftists may say/wish.  McCain, thus, is far closer to the center of gravity than Bush, who in turn is closer than Obama or Clinton. The GOP is far less dependent on centrists to win elections than Democrats are.


2) The notion that McCain is 'not conservative enough' does not stand up to statistical evidence. Those who whine about McCain's support for amnesty of illegals or compromises on judicial appointments forget that even Ronald Reagan did three things that were not purely conservative.

a) Reagan granted amnesty to illegals in 1986


b) Reagan appointed two moderate Supreme Court Justices, Kennedy and O'Connor, and only one conservative, Scalia.


c) Reagan did increase income taxes, after first lowering them

No President will be purely conservative, nor should he/she be.  So I reject the initial conservative hostility to McCain (which seems to have somewhat abated). The job of a political party is to win elections, and the fact that Republicans span a wider ideological spectrum than Democrats should be a source of pride, which brings us to observation #3.


3) The Democratic Party has been enslaved by fringe leftists.  Obama and Clinton are nearly identical in ideology, yet very far to the left of the center of gravity.  The purple oval I have inserted, along with the question mark, represents a vacuum in the moderate left.  A large number of voters clearly reside there, but the Democratic party of today will not nominate someone who resides in the purple zone, leaving these voters as ideological orphans.  Thus, Clinton and Obama have to lie (assisted by a complicit leftist media) to appear more moderate than they are, and hope that the public doesn't figure that out.


Joseph Lieberman, the VP candidate against Bush/Cheney just seven years ago, was run out of the Democratic Party simply for not being opposed to bringing democracy to Iraq.  Bill Clinton's actions of supporting free trade agreements like NAFTA, sending troops to fight proto-Al-Qaeda terrorists in Somalia in 1993, reforming welfare, cutting taxes on capital gains in 1997, attacking Saddam Hussein to remove his WMD programs in 1998, etc. are all actions that the modern Democratic party would not take.


I am a political moderate, in that I care about only three issues.  These are, in order of importance to me :

a) aggresively fighting against terrorists and other enemies of democracy and women's rights,


b) the preservation of free market meritocracy, and the use of market forces to solve problems, and


c) a judicial system that punishes crime, instead of ignoring justice and proceeding to reward the criminal as a poster-child for some perverted cause.

I have a neutral/uninterested position on abortion, gay marriage, gun ownership, prayer in schools, and many other domestic issues.  Yet, I am considered 'right wing' by some extreme leftists, on account of holding the above three positions alone.  Until 2001, it did not even occur to me that only one of the two parties still advocates these three basic principles - I assumed that these were values held by any logical person.  I wish I had a true choice between two parties, but I don't.  In the words of once-Democrat Ronald Reagan, I did not move away from the Democratic Party, it moved away from me.


The moderate left died in 1968, when two of their most promising young leaders were assassinated.  Since then, Democrats have only won three of the last ten elections.  After the disaster of Jimmy Carter, Democrats never again won 50% of the popular vote in SEVEN attempts, while Republicans achieved this feat 4 times over that period (1980, 84, 88, 2004).  This is a truly shambolic performance from the Democrats of the modern era.  Jimmy Carter did more to ensure a generation of GOP dominance than Reagan, Gingrich, Limbaugh, or Rove ever could.


Furthermore, Democrats are not capable of getting a majority of voters who earn over $30,000 a year.  The middle class earning between $50,000 and $75,000 voted just 44% for Democrats.  A party that is soundly rejected by the middle class and upper class is not positioned for long-term success.


2008 is a year where more factors, from a weak economy to an unpopular incumbent, are working against Republicans than at any time since 1976.  Thus, Democrats should be in a position to win by a landslide, but even now are trailing in the polls, and have at best a 50/50 chance of winning the White House in November, with a nominee far more distant from the voting public than John McCain is.  Even if, say, Obama wins, he might repeat the Carter-esqe phenomenon of ensuring another generation of GOP dominance starting from 2012.  If 2008 is 1976, 2012 could be 1980.


Once again, the job of a political party is to attract the votes of 50% of the public, and Democrats can only hope to achieve this by fluke.  If Democrats want to become a national party again, they must move into the purple zone, period.  I sincerely want them to do this, as this will force the GOP to compete to become a better party as well, rather than stagnate into mediocrity with the knowledge that they only have to be better than the most pathetic of opponents.  


When will Democrats purge the leftists and move to the center?

Energy vs. Financials, A Divergence of Historical Extremes

Energy and Financials are both large sectoral components of the S&P500.  Yet the two have diverged immensely over the last 2 years.  Not since the technology bust at the start of the decade have any two sectors diverged so much from each other, and from the composite S&P500 index. 

XLE is an exchanged-traded fund for the Energy sector, while XLF is the equivalent for the Financial sector.  First, let us view a two-year chart : 

Xlexlf2_3

Energy has outperformed the S&P500 by an equal margin that Financials have lagged the S&P500 by.  Next, we can view a five-year chart :

Xlfxle_3

While Financials only began to fall away in 2007, Energy has gone so high above the composite market that it reminds one of the technology bubble of the late 1990s. 

It seems quite obvious here that while it is impossible to identify the exact top of the Energy run, or the exact bottom of the Financials correction, it would be very prudent to sell any existing holdings in Energy (or even short Energy if you have the appetite) and rotate the proceeds into Financials.  The gap could widen in the short term, but rarely do two sectors reach such extreme disparities that make a profitable trade so obvious. 

(crossposted on TechSector).

Reverend Jeremiah White,…I mean, Wright

WrightobamaThe Futurist, above all else, is devoted to bringing original ideas, observations, and analyses to the blogosphere.  The Jeremiah Wright controversy has been heavily analyzed from a mind-boggling array of angles.  Yet one noteworthy detail just has not emerged in the discussion.  Maybe, as an Indian-American, I am truly a third party, and what was utterly invisible to the two races involved in the discussion, was somehow the very first question that entered my mind. 

What immediately struck me is that Barack Obama, who is half Kenyan and half white, still has a darker skin tone than Jeremiah Wright.  Indeed, in Africa, Barack Obama himself would be considered white.  Could it be that less than half of Mr. Wright's ancestors are black? 

Halle_berry_in_hamburg_2004To be fair, one must examine additional datapoints.  Fortunately, this research exercise required no additional effort beyond what I was about to do anyway.  I proceeded to search for photographs of Halle Berry, known to have had one white parent, in order to assess her skin tone.  She, too, appears to be of a similar hue as Barack Obama, but distinctly darker than Wright.  Here is more video footage of Wright.  There just is not enough evidence to believe that even 50% of Mr. Wright's DNA originated from sub-Saharan Africa.  Clearly, more than 50% of his ancestry is white. 

Reverend Wright has built a career out of being a leader to a community from which less than 50% of his ancestry comes from, while condemning a race that apparently more than 50% of his ancestry comes from.  He could just as easily have been a pastor in a white community, where the average skin tone would be closer to his own.  White Americans have become so post-racial that it has entirely escaped their notice that the man can scarcely be considered black.  His defenders claim that his anger is a byproduct of the racism he experienced in the Jim Crow era, yet he is actively applying the one-drop rule to himself. 

It is curious that a man who refers to this country as the "U.S. of KKK-A", managed to attend the University of Chicago, and will soon reside in a 10,340 square foot mansion that his church has provided to him.  Most white people are not fortunate enough to live in homes of that size.  Indeed, most Harvard graduates don't manage to acquire such an impressive residence.  Far from shame America, he has demonstrated how generous, to the illogical extreme, this country is.  Nowhere else can someone with light skin pretend to be black, then condemn whites who are closer to his own skin color, and in the process achieve wealth from a nation while simultaneously condemning the same nation through the worst possible insults. 

It appears that Reverend Wright identified a profitable niche, positioned his career accordingly, and reaped a rich bounty.  As appalled as I am as an American, I am just as impressed as an entrepreneur. 

Only in America......

We shall close with a poll.  Choose multiple answers if desired (poll closed 4/21/08).

Wright

A Rebuttal to ‘Peak Oil’ Doomsday Predictions

At The Oil Drum, a detailed article by 'Gail the Actuary' speculates on how declining production of oil combined with rising demand will cause an economic catastrophe, leading to the global economy contracting so severely, that by 2040 it is much smaller than it is today.  The author actually believes that in 2040, most people will no longer be able to afford cars, electricity will be unreliable, and goods and services will be fewer and rarer than today. 


Another article submitted by an different contributor on The Oil Drum arrives at the same pessimistic conclusion, stating that 'economic growth will end one way or another'Most of the commenters on both articles are in a groupthink state of agreement that can best be described as a Maoist-Malthusian cult. 


I would normally not bother to rebut something like this, except that this particular essay is so stunningly wrong and annoyingly pessimistic, despite the seemingly meticulous research the author has conducted, that I am compelled to disect how insulated groupthink can spiral into a zone where even the most extreme conclusions are accepted. 


Note that I happen to be someone who actually does believe in Peak Oil theory, but that such a condition generates long-term positives that outweigh short-term negatives


The assumptions that the 'Peak Oil' doomsday scenario makes are :


1) That rising oil prices do not cause a long-term downward adjustment in demand.  Oil demand may be inelastic in the short-term, but in the long term, people will buy more efficient cars, carpool, ride bicycles, reduce discretionary trips, conduct more commerce online, etc.  To assume otherwise is to ignore the most basic law of economics.  This is before even accounting for the indirect benefits of declining oil demand such as a drop in traffic fatalities (which cost $2 million apiece to the economy), less wear and tear on roads and tires, less pollution, less real estate consumed by gas stations, less competition for parking spaces, etc. 


2) That rising grain prices will not move consumption away from increasingly expensive meat towards affordable grains, fruits, and vegetables, thereby reducing grain and water demand.  This, too, is economic illiteracy.  If the price of beef triples while the price of rice and potatoes does not, consumption patterns shift.   


3) That there will be very little technological innovation in alternative energy, automobile efficiency, batteries, or information technology from this point on.  In fact, there is innovation in all of those areas, so we have multiple layers of protection against the doomsday scenario, as detailed by these articles :


A Future Timeline for Energy


A Future Timeline for Automobiles


Batteries Set to Advance, Finally


Solar Energy Cost Curve


Terrorism, Oil, Globalization, and the Impact of Computing


4) That most economic growth is now in knowledge-based industries, which consume far less energy per dollar of output.  The US economy today produces twice the financial output per unit of oil consumption as it did in 1975, with information technology rising as a portion of total economic output. 


5) That a major economic downturn, featuring skyrocketing food prices for people in poorer countries, will somehow not translate to a lower birth rate that inhibits population growth and hence curbs demand, and that population projections will somehow not change. 


6) That there will be no humans living beyond the Earth (whether in orbit or on the Moon) by 2040.  The reason this point is relevant is because a society cannot advance in space travel without simultaneous advances in energy technology.  I say that advances in photovoltaic efficiency make Lunar colonies closer to viability by that time. 


7) That we are going to have over 30 years of negative growth in World GDP, despite not having had a single year of negative growth since 1973, and despite the trendline of growth solidly registering at 4.5% a year even today.  I happen to think that by 2040, the world economy will be 4 times larger than it is today.  Even the Great Depression was only 5 years of negative growth, followed by a recovery that elevated prosperity to levels higher than they were in 1929, at a time when World GDP was only at a trendline of 2% annual growth, or less than half the level of today.  Yet Gail the Actuary thinks car ownership will no longer be affordable to most people by 2040. 


Peak oil may be on the horizon, but the US economy has already adapted to oil at sustained prices of $70 or $80/barrel (which is the biggest story that no one is noticing yet), and will soon adapt to $100/barrel.  I want oil to hit a sustained $120/barrel by 2010 to start a virtuous cycle of technological and geopolitical chain reactions that make the world a better place in the long term.  If oil hits $200/barrel, that will cause a deep recession that could last several years, but after that point, we will have adapted out of the oil burden almost entirely, and World GDP growth will resume at 5% a year. 


Could I be wrong and they be right?  Well, let us first see if oil rises substantially above $120/barrel, and if that year has negative World GDP. 


Does anyone feel like defending the doomsday prediction from The Oil Drum?

Actuarial Escape Velocity

Every now and then, an obscure concept is so brilliantly encapsulated in a compact yet sublime term that it leaves the audience inspired enough to evangelize it. 

I have felt that way ever since I heard the words 'Actuarial Escape Velocity'.

For some background, please refer to an older article from early 2006, 'Are You Prepared to Live to 100?".  Notice the historical uptrend in human life expectancy, and the accelerating rate of increases.  For more, do also read the article "Are You Acceleration Aware?".

In analyzing the rate at which life expectancy is increasing in the wealthiest nations, we see that US life expectancy is now increasing by 0.2 years, every yearNotably, the death rates from heart disease and cancer have been dropping by a rapid 2-4% each year, and these two leading causes of death are quickly falling off, despite rising obesity and a worsening American diet over the same period.  Just a few decades ago, the rate on increase in life expectancy was slower than 0.2 years per year.  In the 19th century, even the wealthiest societies were adding well under 0.1 years per year.  But how quickly can the rate of increase continue to rise, and does it eventually saturate as each unit of gain becomes increasingly harder to achieve?

Two of the leading thinkers in the field of life extension, Ray Kurzweil and Aubrey de Grey, believe that by the 2020s, human life expectancy will increase by more than one year every year (in 2002 Kurzweil predicted that this would happen as soon as 2013, but this is just another example of him consistently overestimating the rate of change).  This means that death will approach the average person at a slower rate than the rate of technology-driven lifespan increases.  It does not mean all death suddenly stops, but it does mean than those who are not close to death do have a possibility of indefinite lifespan after AEV is reached.  David Gobel, founder of the Methuselah Foundation, has termed this as Actuarial Escape Velocity (AEV), essentially comparing the rate of lifespan extension to the speed at which a spacecraft can surpass the gravitiational pull of the planet it launches from, breaking free of the gravitational force.  Thus, life expectancy is currently, as of 2007 data, rising at 20% of Actuarial Escape Velocity.

I remain unconvinced that such improvements will be reached as soon as Ray Kurzeil and Aubrey de Grey predict.  I will be convinced after we clearly achieve 50% of AEV in developed countries, where six months are added to life expectancy every year.  It is possible that the interval between 50% and 100% of AEV comprises less than a decade, but I'll re-evaluate my assumptions when 50% is achieved. 

Serious research efforts are underway.  The Methuselah Mouse Prize will award a large grant to researchers that can demonstrate substantial increases in the lifespan of a mouse (more from The Economist).  Once credible gains can be demonstrated, funding for the research will increase by orders of magnitude. 

The enormous market demand for lifespan extension technologies is not in dispute.  There are currently 95,000 individuals in the world with a net worth greater than $30 million, including 1125 billionaires.  Accelerating Economic Growth is already growing the ranks of the ultrawealthy at a scorching pace.  If only some percentage of these individuals are willing to pay a large portion of their wealth in order to receive a decade or two more of healthy life, particularly since money can be earned back in the new lease on life, then such treatment already has a market opportunity in the hundreds of billions of dollars.  The reduction in the economic costs of disease, funerals, etc. are an added bonus.  Market demand, however, cannot always supercede the will of nature. 

This is only the second article on life extension that I have written on The Futurist, out of 154 total articles written to date.  While I certainly think aging will be slowed down to the extent that many of us will surpass the century mark, it will take much more for me to join the ranks of those who believe aging can be truly reversed.  To track progress in this field, keep one eye on the rate of decline in cancer and heart disease deaths, and another eye on the Methuselah Mouse Prize.  That such metrics are even advancing on a yearly basis is already remarkable, but monitoring anything more than these two measures, at this time, would be premature. 

So let's find out what the group prediction is, with a poll.  Keep in mind that most people are biased towards believing this date will fall within their own lifetimes :

When will Actuarial Escape Velocity be achieved for wealthy individuals?
2010-2020
2020-2030
2030-2040
2040-2050
2050 or later, if ever
  
Free polls from Pollhost.com

How Far Can ‘Medical Tourism’ Go?

Studying what lies beneath the surface of market forces can be fascinating.

BusinessWeek has a slideshow depicting major centers for medical tourism, as well as the cost savings of various procedures in relation to the US.  This got me thinking about several dimensions of this concept, particularly since healthcare is 15% of the US economy, yet is also the sector of the US economy, outside of government, where wastage and ineffeciencies are the greatest. 

Many procedures that cost $100,000 or more in the US can be done with equal competence for $10,000 in Thailand or India.  Normally, if something of comparable quality is available for just a tenth of the cost, demand migrates to the cheaper alternative in a huge torrent.  Even after accounting for travel costs, the gulf is immense.  Yet it appears that only a small percentage of US patients for cardiovascular surgery, joint replacements, etc. are going overseas for their operations.  Medical tourism will still only earn a miniscule $4 Billion in 2008 for India, Thailand, and Singapore combined, of which only one-third is from American patients.  Thus, only a fraction of a percent of the US, European, and Japanese healthcare sectors have been dented. 

This, of course, can be due to two reasons :

a) Fears about quality/safety, either real or perceived.

b) Net out-of-pocket cost to the patient still being lower in the US, due to insurance. 

Regarding quality, many of these surgeons are certified by US boards or even educated in US colleges, and accidents do not appear to happen at any greater rate than in the US.  At the same time, it is not possible to pursue malpractice suits against facilities in India or Thailand, which, while certainly an element of risk, itself is part of the reason for their lower price relative to the US.  It is inevitable that some mishap befalls an American patient in Asia, and the media latches onto the story for a week or more, reversing the market demand for medical tourism for years, even if the incidence of such tragedies may be no more than in US hospitals.  In fact, I am surprised it has not happened already. 

In terms of cost, that brings us to the elephant in the room, which is the revelation that it is not India or Thailand that are too cheap, but rather that US healthcare is too expensive to begin with.  I am no expert in this field, but it seems obvious that a lack of market forces in the value chain, a lack of regulation of lawsuits, the horrendous dietary habits of most Americans, and the tendency of consumers to not care about how much the insurance company pays are all contributory factors to what is arguably the greatest tragedy in US economic history.  Socializing the healthcare system will worsen it, for reasons too vast to delve into here.  It is true that many Canadians come to the US for urgent procedures that would require a 3-month wait in Canada. 

However, millions of Americans don't have health insurance at all, and while for some this is by choice, for some it is not.  For them, traveling abroad for a $10,000 heart procedure may be the only affordable option.  Even if the most experienced and well-frequented facilities are in India and Thailand, nearby options also exist in Jamaica and Costa Rica.  Over 20 other countries across Eastern Europe, Asia, and Latin America are also vying for a slice of the pie. 

As unintended consequences ripple through, herein lies the path to forcing some degree of reform of the US healthcare system.  As more Americans either choose or are forced to seek low-cost procedures abroad, even if it is only a small percentage American patients, this will compel insurance companies to include medical tourism options to patients.  The insurance company can offer their own version of malpractice insurance to the patient, cover all travel expenses for the patient and spouse, and even throw in a vacation package and cash incentive.  Even after all this, if the cost of the $10,000 procedure in India or Thailand has now risen to $30,000, it still outcompetes the $100,000 US alternative handily.  Some insurance companies are already starting this with enthusiasm, and before long, all insurance companies will effectively have to compete on this level

As the number of Americans combining surgeries with a tropical vacation becomes a small but significant percentage of the total patient pool, the US healthcare system will have no choice but to undertake the difficult reforms to bring costs down at a systemic level, thus benefiting even those Americans who refuse to go overseas, and even procedures that are not candidates for offshoring.  If software development can be outsourced to India where it is one fourth the cost, surgeries cannot expect to be perpetually immune to competition that is a tenth or twentieth of the cost.  Through some combination of tort reform, free-market principles, and preventative focus, US costs will gradually be brought down closer to a market rate.  Perhaps the US can comfortably sustain prices that are 3 times that of Thailand, but not 10 times.  This will be the next industry in the US that is forced to adapt. 

To review, the expected sequence of events is :

1) Americans with no insurance are forced to make a life or death decision to get their surguries abroad, where the service meets or exceeds their expectations. 

2) More insurance companies offer medical tourism with liability guarantees and cash/vacation incentives to American patients.  Only a small fraction of patients are adventurous enough to do this, but all insurance companies are compelled to offer these options.

3) Major centers for medical tourism, after a track record of about a decade, develop solid brands that can attract American patients. 

4) When we finally get to the point that 10% of Americans are traveling abroad for a wide array of procedures, the US will be forced to begin to take measures to reduce costs throughout the healthcare system.  Losing 10% of the market is all that it will take to force some positive changes.  This could begin to happen by 2020. 

Such a sequence of events, of course, will boost the US economy greatly.  Of the $2 Trillion mentioned above, as much as half of that, a whopping $1 Trillion or 7% of the US economy, is estimated to be wastage incurred due to a shortage of market forces in healthcare.  Imagine if that $1 Trillion could be redeployed elsewhere.  A person who saves $90,000 on a heart procedure can choose to use that money on emerging innovations in biotechnology that may be available in the 2020s, such as treatments to slow down or halt some aspects of aging

This is not going to be a trend that moves as quickly as some of the others discussed here on The Futurist.  But the economics involved are massive enough that it has certainly caught my eye.  Let's see what happens, both before and after the predicted media frenzy over a foreign medical mishap. 

Update (4/3/08) : Businessweek has an article on how technological advances in medical instrumentation are enabling some surgical procedures to be done with far tinier incisions.  Patients who previously would have to stay in the hospital for a week to recover now can leave in under a day. 

The article also mentions how hospitals are opposed to these technological advancements, as they reduce the number of days of revenue a hospital can collect while a patient recovers after surgury.  This anti-productive, entitlement mentality will hasten the downfall of the US healthcare cartel, as shorter recovery times due to smaller incisions will make a trip to a tech-friendly facility in Thailand or India even more compelling.  When the cost is a tenth and the recovery time is a fifth of what it would be in the US, how long before market forces dominate?

Nanotechnology in medicine


Nanotechnology is the science of maneuvering and modifying the structure and properties of matter at an atomic and molecular scale. Due to these manipulations, inert elements start to function as catalyst, and insoluble matter develop unique solubility capacity. Likewise, non-colloids begin exhibiting excellent colloidal properties and electrical non-conductors start conducting electricity. All these materials can be used for a vast variety of purposes in field as diverse as medicine, energy production and electronics.

In recent years, nanotechnology has found innumerable applications in the field of medicine — from drug delivery systems, nanorobots and cell repair machines to imaging, nanoparticles and nanonephrology. Owing to the extensive use of nanomaterials in medical equipments and devices, nanomedicine has become a significant branch of nanotechnology. Here are some important uses of nanotechnology in the field of medicine. All these things prove that nanotechnology will play a significant role in the future, and shows why is nanotechnology useful.

Drug delivery system and nanoparticles
The primary objective of the drug delivery system is to make the life-saving drug available in that part of the body where it is required the most. However, most of the time, these systems fail to work efficiently because the particles of the drug are too large for the cells to absorb, or they are insoluble or they have the potential to cause tissue damage. On the other hand, due to their exceedingly small size, nanoparticles are easily taken up by the cell. Moreover, they are completely soluble and they do not also damage the tissues. In nutshell, the efficiency of the drug delivery system can be increased several times by integrating nanoparticles with them.
Coupling of nanoparticles with biopharmaceuticals
Biopharmaceuticals are peptides or protein molecules that trigger multiple reactions in the human body. They are widely used in the treatment of life-threatening diseases like cancer. The effectiveness of biopharmaceuticals can be increased several times by coupling them with nanoparticles, which will proficiently deliver the peptides or proteins at the tumor site and in this manner cure cancer without causing extensive damage to the adjacent tissues and organs.

Nanotechnology and neuro-electronic devices
Neuro-electronic devices are unique machines based on nanotechnology that connect the nervous system with the computer. These devices not just detect and interpret the signals from the nervous system, but also control and respond to them. They can be used in the treatment of diseases that slowly and steadily decay the nervous system like multiple sclerosis.

Nanonephrology
This is a sub-branch of nanomedicine which is concerned with the detection and treatment of kidney diseases. Here various devices based on nanotechnology are used for the studying the different kidney processes and detecting disorders. Thereafter, nanoparticles and drug delivery system are used for curing the disorder.

Nanotechnology and cell repair machines
These cell repair machines use nanotechnology to penetrate into the cell and rectify disorders like DNA damage or enzyme deficiency. These machines are no bigger than a bacteria or virus.

Nanorobots
The entry of nanorobots will literally revolutionize the world of medicine. These miniature devices would not only be capable of entering into the body and detecting the diseases and infection, but they will also be capable of repairing internal injuries and wounds.

Nanotech and Cancer


Nanotechnology deals with manipulating the structure as well as properties of matter at the atomic and molecular level. As the result of this maneuvering, the properties of matter change dramatically. While some insoluble elements develop high solubility capacity, inert substances start exhibiting catalyst properties. Owning to their size and properties, nanomaterials are extensively used for the treatment of a number of diseases. Cancer is such a disease where nanotechnology can play a significant role.

Nanoparticles and nanorobots
Cancer is a condition where changes occur in a small percentage of cells and they start replicating interminably. Problems come to the fore only when the condition becomes unmanageable. The size of nanoparticles and nanorobots is exceedingly small, and because of this property, they can easily enter into the blood vessels, organs, tissues and even the cells of the body. Additionally, they can also find out those cells that are growing abnormally. Thus, they can play a decisive role in the detection of cancer at a very early stage.

Accurate drug delivery
Once the cancer has been detected, it becomes essential to treat it as quickly as possible. Most of the cancer treatment methods cause widespread damage because while eliminating the cancerous cells they also start acting upon the normal cells. Drug delivery systems that use nanoparticles can effectively treat cancer without damaging the surrounding cells and tissues. These nanoparticles are smaller than the body cells, and can easily carry the drug to that part of the body where the cancerous cells are located.

Biopharmaceuticals and cancer
Biopharmaceuticals are basically proteins molecules that trigger multiple reactions in the human body. They are widely used in the treatment of cancer. The effectiveness of these pharmaceuticals will increase several times if they are coupled with nanoparticles. The nanoparticles will carry the biopharmaceuticals directly to the tumor site without adversely affecting the cells and tissues that come in the way. In this manner, cancer would be cured and healthy cells will remain as such.

Cell repair machine and cancer treatment
Cancer primarily occurs due to mutation; the genetic information stored in the DNA is changed. As the result the affected cells divide continuously and cause the formation of tumors. The cell repair machine that is as small as a nanoparticle can easily penetrate into the cancerous cell and repair the damaged DNA. As the technique is completely non-invasive, therefore the normal cells remain unharmed.

History of nanotechnology


In 1974, Norio Taniguchi of the Tokyo Science University, defined the term nanotechnology for the first time. According to his definition, nanotechnology encompasses separating, processing, consolidating and deforming matter at atomic and molecular scales. Although the term nanotechnology got its definition in 1974, the actual concept was introduced way back in 1867, when James Clerk Maxwell proposed a minuscule entity called Maxwell’s Demon that was capable of handling individual molecules.
Richard Adolf Zsigmondy was the first person to observe and measure the dimensions of nanoparticles. He was also the first person to use nanometer for characterizing the size of the nanoparticles unambiguously. He determined that 1 nm was 1/1,000,000 millimeter. He also developed the first classification system that was based on size of the particle that ranged in nanometer.

In the 20th century several developments took place that helped in characterizing nanomaterials. Like in 1920, Irving Langmuir introduced the concept of monolayer, where a layer of material is just one molecule thick. He received a Nobel Prize for this concept.
In 1959, Richard Feynman, at a meeting of American Physical Society at Caltech, put forth a process that had the ability to control and modify individual atoms and molecules. He stated that by scaling down the dimensions of the atom, dramatic changes can be brought about in its properties. After the discourse, he announced two challenges; first was the construction of nanomotor, which achieved by William McLellan in 1960,and second involved the process of scaling down the letters of Britannica Encyclopedia to fit on the head of a pin; this task was accomplished by Tom Newman in 1985.
In 1965, Gordon Moore made an astounding prediction; he stated that the number of transistors that could fit in a specific area would double every 18 years for the next 10 years. Till this date the trend is continuing, from 2000 transistors in 4004 processors to 7,000,000,000 transistors in Core 2, and Gordon’s prediction is popularly known as Moore’s Law.
In 1974, Dr. Tuomu Suntola et al. patented the atomic layer deposition process. Through this process it became possible to deposit uniformly thin films, one atomic layer at one time. In the 1980s, nanotechnology no longer remained stochastic, but became deterministic. During this period, Dr. K. Eric Drexler advocated the significance of nanomaterials and devices.

So much of groundwork on nanotechnology made the process of production and implementation of nanomaterials relatively simple.

Where will medicine be 20 years from now


In today’s technological age, it seems advancements in all fields leap forward by the day. Medical technology certainly hasn’t been left out of the loop, and some of the breakthroughs in modern medicine have been quite revolutionary and had a huge impact. But where will the field of medicine be in 20 years from now? What major advancements are waiting just around the next corner? In this article we will consider just two of the biggest technologies that are emerging over the horizon.

Electronic Implants

We have computers everywhere these days, but it’s not just the ones on our desks that we use to surf the net. We have computer chips in washing machines and just about all of our other appliances too. In the realm of science fiction (all too often a prediction of future science) we have seen technologically enhanced humans with superhuman abilities but what if those technologies were real and used for medical purposes?
Scientists have been working for years on implementing a special kind of microchip known as a “neuroprosthetic chip” that can be implanted into the brain. This chip helps to decipher signals in the brain when the brain itself cannot, and to trigger the appropriate responses. For example, the chip could help to control epileptic seizures, or help a patient suffering with paralysis to control prosthetic limbs with thought alone.

Stem Cell Research

One of the most talked about areas of medical technology today is stem cell research. With the first human trials currently taking place to determine the safety of human treatment, stem cell technology may not be too far away. The basis of stem cell therapy is regenerative: stem cells help the body to form new cells and generate tissue. If we can harness the power of stem cells for medical use, we may be able to cure paralysis, blindness, heart disease and diabetes, treat stroke patients and repair damaged organs and tissues, helping the body to regenerate and cure itself. Some people are even optimistic that stem cell research could lead to curing cancer!
Stem cell research has been the subject of much controversy. The needed stem cells are actually taken from embryos developed using IVF techniques as there are often surplus embryos and these are donated for scientific use. The stem cells gathered in this way are generic and have no predetermined cell type, which enables scientists to force the stem cells to become a specific, needed type of cell that can be injected into a patient in need of them. The embryos are only a few days old and about the size of a full stop (period), but there are many who think that stem cell research is just plain wrong; that it is “playing God” with an unborn child. This may all change as new research shed light on the ability to use adult stem cells, but only time will tell.

Nanomedicine

Nanotechnology, especially nanomedicine, are advancing significantly day by day. Nanoparticles are being already used in many products (mainly in cosmetics), but other spheres such as pharmaceutics and general medicine are slowly applying nanotechnology standards.
Nanomedicine, along with stem cells research, will probably change the way the world sees medicine. Many experts predict that it will change everything.

This was just a brief look at what the future of medicine may hold for us, but with these and many more exciting technologies rapidly emerging that future certainly looks bright.

Quick blood tests by using a nanodevice


Scientists from the University of Southampton’s School of Electronics and Computer Science have gotten an assignment to create a special technique to produce nanowires, which would make mass production possible. The final goal is to be able to perform quick blood tests without the need to go to a laboratory.

The British researchers are using the standards that are currently being used in making television displays. The need for quick blood tests, which could be done during surgery, are in demand and would help significantly. Peter Ashburn, the leading researcher, said: “Standard clinical laboratory tests have limitations outside the laboratory, which can reduce the diagnostic impact of new protein biomarkers for complex conditions like cancer and chronic inflammation,” said Professor Ashburn. “One-dimensional nanostructures such as nanowires are ideal for diagnosis as they can be integrated into microfluidic chips that provide a complete sensor system.”

The research is supposed to end within three years.

Fluorescent molecules can be biomarkers


Scientists from the Pennsylvania State University have found that a high amount of fluorescent molecules that naturally reside in human’s body can be used as biomarkers for cancer.

NADH (nicotinamide adenine dinucleotide) is an enzyme found in mitochondria. “Dysfunctional enzymes in the mitochondria are known to be associated with serious health problems such as cancer and neurodegenerative diseases,” said Ahmed Heikal, one of the researchers. “By detecting the level of NADH and its distribution inside living cells, we should be able to monitor the mitochondrial activity and thus the integrity of any given cell, without adding potentially toxic dyes or actually destroying the cell.”

The main catch that scientists are working on is to be able to differentiate normal healthy cells from the “bad” cancer ones. Now, by using special techniques, they were able to make that happen.
“If we are given two live cells, one normal and the other cancerous, we could differentiate between the two with confidence,” said Heikal.

“Our method is not limited to detecting cancer. Other neurodegenerative diseases related to mitochondrial anomalies can also be detected with our method,” said Heikal. “We can also use our approach to quantify the efficiency of a new drug on manipulating the activities of mitochondrial enzymes associated with energy production in cells.”

Adopted from materials provided by psu.edu

Lasers can destroy cancer cells


Researchers from Rice University, led by Professor Yildiz Bayazitoglu, have performed a research which showed that by combining two lasers and pointing them to nanoparticles in order to heat them up, it is possible to destroy the “bad” tissue, with minimum damage to healthy cells.

Of course, lasers and nanoparticles are already used in nanomedicine for treating cancer — the technique is based on using nanoshells and heating them up by near-infrared laser.

The outcome of this research depends on the properties of nanoparticles — their light-scatter in particular. “We’re afraid that the nanoparticles located near the surface of a tumor will block a laser from reaching those at the center.”

The details are published in International Journal of Heat and Mass Transfer.

Adopted from materials provided by UPI.com

A new way of treating cancer on the way?


A team of scientists from the University of Toronto have found that, by modifying a protein that improves the process of preventing cancer growth, a new way of treating cancer is on the way. The protein they have been researching is called von Hippel-Lindau (VHL).

Tumors are known to have very low blood supply when they grow. Therefore, some parts — including the center of the tumor — have low levels of oxygen and are said to be hypoxic. Cells in these parts produce hypoxia-inducible factor (HIF) that makes it possible for them to keep on growing. Now, under normal conditions VHL degrades HIF — but VHL is deactivated when oxygen levels are low. So, in hypoxic regions of a tumour, just where VHL is needed to inhibit cancer, it is ineffective. That’s why scientists created a new type of VHL — a type that doesn’t stop working if oxygen levels are low.

“We have genetically removed the Achilles’ heel of VHL to permit unrestricted destruction of HIF,” said Michael Ohh, one of the researchers. “The level of HIF is usually very high under conditions of low oxygen but when we put in our bioengineered VHL its levels go right down to a level that would be comparable to that in normal oxygen levels.”

The details are published in EMBO Molecular Medicine.

Adopted from materials provided by the University of Toronto

Taiwan exploring how nanotech affects health


Taiwan, among other Asian countries, is heavily investing in nanotechnology — especially nanomedicine. They recognized the potential, and they’re jumping into it. However, they’re being cautious — National Cheng Kung University in Taiwan started a project which is supposed to explore the effects of nanotechnology on health.

The main goal of this research is to minimize the side effects caused by products based on nanotechnology. The officials in Taiwan reported that the value of products based on nanotechnology standards is over US$8.8 billion.
“Most of the simulation software currently used for nanotechnology research and its effect on the human body only supports the computation of either inorganic material or organic molecules. NCKU is the first institute to achieve a breakthrough that combines the simulation of organic and inorganic substances,” said Michael Lai, one of the researchers.

Is there an alternative to radiation


You may have heard that nanotechnology is already being applied in many industry branches, but probably the most promising subfield of nanotechnology is nanomedicine. Researchers from the University of Alberta, led by Jie Chen, are working on developing a new technique which would allow them to replace chemotherapy and radiation, thus “killing” all the side effects caused by these methods.

The researching crew is doing experiments with injected nanoparticles that contain a bamboo compound that is sensitive to ultrasound. “So when the ultrasound is used and treated or targeted towards these compounds, then you will activate and generate something which can destroy the cancer, so it’s much safer compared to the conventional radiation,” said Chen.

As always when new technologies arise, security concerns come in the way. “It has been shown in animal experiments for example that very small particles can overcome the intestinal barrier and can go into the bloodstream and can go into the organs,” said Herman Stamm, a member of European Commission’s Joint Research Center. What they worry about is that the injected nanoparticles don’t really destroy themselves. They can actually stay in your body and go somewhere where they are not intended to go. Of course, that can cause problems.

Adopted from materials provided by cbc.ca

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