An astronaut spotted SpaceX’s Starlink internet satellites from the International Space Station – CNBC

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A photo taken by an astronaut from the International Space Station on April 13, 2020.

NASA

An astronaut on the International Space Stationlast week captured a unique view of SpaceX's Starlink satellites photographing a group of the satellites in space, from space.

Starlink isSpaceX's plan to build a network of about 12,000 small satellites to provide high-speed internet to anywhere in the world.The company has launched 360 Starlink satellites in the past year and aims to begin offering early, limited service later in 2020.

The train of Starlink satellites that were photographed areSpaceX's fifth Starlink launch.

A cropped and edited photo shows the trail of Starlink satellites in this photo taken by an astronaut from the International Space Station on April 13, 2020.

NASA

Jonathan McDowell, an astronomer at the Harvard-Smithsonian Center for Astrophysics, shared a data visualization of the locations of the Starlink satellites when the photo was taken.

The location of SpaceX's Starlink satellites (red) compared to the International Space Station (blue) on April 13, 2020.

Jonathan McDowell

Starlink is an ambitious project that will require billions in capital to succeed, given the costs of building the required ground infrastructure in addition to the hardware and operating costs of the satellites in space.SpaceX has said it expects it will cost about $10 billion or more to build the Starlink network.

Starlink will make the company the world's largest satellite operator by number of spacecraft.If SpaceX can overcome the technological challenges of building and distributing this service, the company is optimistic on its potential demand and revenue. SpaceX CEOElon Muskin May told reportersthat Starlink could bring in revenue of $30 billion a year or about 10 times the highest annual revenue it expects from its core rocket business.

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Fresh fears of coronavirus on International Space Station as expert with link to astronauts deteriorates wit – The Sun

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THERE are fresh fears of coronavirus onboard the International Space Station after a top official who was close to astronauts has deteriorated with Covid-19.

Virus-struck Evgeniy Mikrin - deputy head of Energia Rocket and Space Corporation - travelled with another top official who met with three astronauts, and who now appears to be self-isolating.

Head of Roscosmos, Dmitry Rogozin, 56, formerly Putins deputy prime minister had met face to face with the two Russian cosmonauts and one US astronaut who flew to the ISS from Baikonur on 9 April.

He travelled to and from the lauch site with Evgeniy Mikrin - deputy head of Energia Rocket and Space Corporation - who is now seriously ill with coronavirus in Moscows top infectious diseases hospital after his condition deteriorated.

Rogozin shared a tweet today showing him attending a top meeting remotely, sparking fears he could be self-isolating with symptoms, although this hasn't been confirmed.

Russia today announced a record number of daily deaths - 60 - and 5,859 new cases, as the country also faced a threat from wildfires in nine regions with 70 houses destroyed in raging infernos.

Mikrin, 64, is known to have been in close contact with Rogozin on the Baikonur trip although unlike the Roscosmos chief, he was not face to face with the crew.

At the beginning of this week, his condition deteriorated and he was taken to hospital, reported Mosvoksky Komsomolets.

Mikrin flew to see the Soyuz-MS-16 cosmonauts off to the ISS on the same plane as the head of the state corporation Dmitry Rogozin who was then directly talking to cosmonauts and even gave them a traditional good luck kick right before they boarded the space ship.

After the launch it was announced Mikrin was self-isolating at home.

Rogozin yesterday announced that 71 Russian aerospace industry employees have been diagnosed with coronavirus - a figure that has doubled in six days.

The Moscow mayor Sergei Sobyanin hit back at claims that official figures for coronavirus did not tell the whole story.

And he claimed Russian big cities were doing better than in other countries where troops had been put on the streets.

"No one is hiding anything, this story is absolute nonsense, he said.

On the contrary, the more we know about those infected, the potentially infected, the easier it is to fight the infection.

He told Rossiya-24 television channel:"In our country, the situation is different. we test, we carry out as many tests as we have of them, regardless of whether someone has any clear symptoms, is seriously ill.

If they are in a risk group, we try to extend the testing to them.

He said: We have established an optimal self-isolation regime in Moscow which the residents - thank you very much - adhere to.

Most residents act very responsibly.

This allows us not to tighten the administrative measures.

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This regime is optimal for the situation in the city.

Elsewhere soft measures had proved inadequate and the authorities were forced to "deploy troops in the streets."

"We do not want this scenario," he said.

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Fresh fears of coronavirus on International Space Station as expert with link to astronauts deteriorates wit - The Sun

The International Space Station transits the sun – Boing Boing

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Astrophotographer Andrew McCarthy captured this amazing, rather alarming photograph of the International Space Station transiting the sun yesterday.

Thirty year ago today, the space shuttle Discovery carried the Hubble Space Telescope into orbit, opening up a new vista on our place in the universe. In celebration of the anniversary, NASA released this astounding Hubble image of a region where stars are born in the Large Magellanic Cloud, one of the closest galaxies to []

In their upcoming study, so far published on the preprint server arXiv and submitted to Physical Review Letters, Linden and his colleagues examined a decades worth of data from NASAs Fermi Gamma-ray Space Telescope to better analyze the suns emission of gamma raysthe universes most energetic form of electromagnetic radiation.

Right after astronauts Apollo 11 astronauts Neil A. Armstrong, Edwin E. Buzz Aldrin, and Michael Collins splashed down in the Pacific Ocean on July 24, 1969, they were brought aboard the USS Hornet (CVS-12) and immediately entered a Mobile Quarantine Facility (MQF) along with a NASA flight surgeon and recovery engineer. See below for a []

Considering the human races utter dependence on coffee, its no surprise that more than 40 percent of American homes have a single-cup coffee brewing system. Unfortunately, most of those machines take pods made from various plastic and aluminum materials that arent easily recyclable. And while 39,000 of those pods are made every minute worldwide, about []

While CBD is not a cure-all miracle drug, millions of users can be forgiven for feeling that way and singing its praises. CBDs direct medical impact still remains to be fully researched and documented, but those who have become believers in the non-psychoactive cannabis extract say the drug is a godsend, alleviating the symptoms of []

Were all getting pretty schooled in the fine art of DIY these days, even for stuff wed never have dreamed of doing ourselves just two months ago. There are services like housekeeping that we still hate. There are services like bartending that just work better in a group setting. Then there are beauty salons and []

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The International Space Station transits the sun - Boing Boing

That Time Swamp Thing Impregnated a Space-Station | Screen Rant – Screen Rant

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The Swamp Thingwas and remains one of the weirdest characters in the DC Universe, having gone on some of the most bizarre adventures imaginable while fighting the scariest villains DC has to offer. However, things got really outlandish when writer Alan Moore began his legendary run on the character in the '80s -- the strangest of all taking place when he was unwillingly forced to impregnate a sentient space station.

Created by writer Len Wein and artist Bernie Wrightson during the mid-1970s, Swamp Thing debuted as a man named Alec Holland. After being set on fire an explosion and covered in chemicals, Holland was forced to run into a nearby swamp, transforming him into the vegetative creature Swamp Thing. However, during his run the '80s, writer Alan Moore retconned Swamp Things origin so that he was a creature who had copied both memories and personality of Alec Holland after dying in the swamp. This meant that in reality, Swamp Thing was a sentient organism made completely of plants and was connected to an elemental force called the Green. Through the Green, Swamp Thing has the unique ability to control and create new bodies out of any form of plant life on any planet.

Related: How Swamp Thing DEMOLISHED Batman (and Almost Destroyed Gotham)

After having his consciousness expelled from the Earth by a frequency scrambler created by Lex Luthor (a villain to more than just Superman), Swamp Thing accidentally makes contact with a sentient space station made of cybernetic plant life, named Technis. After creating a body out of the station's vegetation, Swamp Thing was horrified to find his new body was mostly made of machinery -- which instantly gained the attention of Technis consciousness. After realizing Swamp Thing was made out of the same material as the station, Technis jumped at the opportunity to use Swamp Things new body. Ripping and clawing apart his half-mechanical body, Technis extracted genetic material and copied Swamp Thing's memories to impregnate itself. After going through such a horrific experience, Swamp Thing left his mechanical body to let his conciseness drift among the cosmos.

What is specifically terrifying and off-putting about this story from Saga of the Swamp Thing #60story is that its told from Techniss point of view, who acts as if this situation is somewhat romantic. This is made even more horrible by the fact that Swamp Thing doesnt consent to any of it; if anything, hes completely unaware of whats happening and sees it simply as a form of torture. Though Swamp Thing is in pain throughout the whole story, Technis claims to be doing it from a place of love. With all this in mind, one must wonder what Moore was intending to say. Perhaps this was a form of commentary on the relationship between technology and nature.

Regardless of Alan Moores intent, it remainsone of the strangest stories everpublished by DC Comics. Body horror was a huge theme during Moores run; however, thisstory brings it to such a terrifyingly sexual level that its almost hard to read today. Though theethical nature of Swamp Thing#60 is certainly divisive, it is also so bizarre that its practicallyimpossible to forget after reading.

More: Swamp Thing Season 2 Video Reveals Detailed Look At Floronic Man Design

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That Time Swamp Thing Impregnated a Space-Station | Screen Rant - Screen Rant

Striking view of Dubai’s Palm Jumeirah from space – The National

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The images were taken by a US astronaut from the International Space Station

Striking photos taken from space capture the Palm Jumeirah and the Dubai coastline.

Nasa astronaut Chris Cassidy shared the crystal clear images from the International Space Station showing the trunk and fronds of the distinctive UAE landmark.

Always an amazing view when you fly over #uae!! he posted on his Instagram account.

Mr Cassidy also wrote that it was inspiring to watch the first flight of Emirati astronaut Hazza Al Mansouri and acknowledged his colleagues at the Mohammed Bin Rashid Space Centre.

Spectacular images of #Dubai from space.

The images were shared by the Dubai Media Office.

Mr Al Mansouri made history as the first UAE citizen to complete a space mission when he was aboard the space station in September last year.

Mr Mansouri too had shared photos of the UAEs western coastline, images of Abu Dhabi city and his home town of Liwa.

"Despite being miles away, my heart longed for the warmth of this land," he had tweeted.

The six crew currently in the orbiting laboratory are scheduled to return to Earth in October and will conduct about 160 investigations in biology and technology development.

Updated: April 26, 2020 08:32 AM

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Striking view of Dubai's Palm Jumeirah from space - The National

Glaucoma Could Be Successfully Treated With Gene Therapy – Technology Networks

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A new study led by the University of Bristol has shown a common eye condition, glaucoma, could be successfully treated with a single injection using gene therapy, which would improve treatment options, effectiveness and quality of life for many patients.

Glaucoma affects over 64 million people worldwide and is a leading cause of irreversible blindness. It is usually caused by fluid building up in the front part of the eye, which increases pressure inside the eye and progressively damages the nerves responsible for sight. Current treatments include either eye drops, laser or surgery, all of which have limitations and disadvantages.

The research team led by academics at the Bristol Medical School: Translational Health Sciences tested a new approach that could provide additional treatment options and benefits. Their findings are published in the journalMolecular Therapy.

The researchers designed a gene therapy and demonstrated proof of concept using experimental mouse models of glaucoma and human donor tissue.

The treatment targeted part of the eye called the ciliary body, which produces the fluid that maintains pressure within the eye. Using the latest gene editing technology called CRISPR, a gene called Aquaporin 1 in the ciliary body was inactivated leading to reduced eye pressure.

Dr Colin Chu, Visiting Senior Research Fellow in theBristol Medical School: Translational Health Sciencesand corresponding author, said: "Currently there is no cure for glaucoma, which can lead to loss of vision if the disease is not diagnosed and treated early.

"We hope to advance towards clinical trials for this new treatment in the near future. If it's successful it could allow a long-term treatment of glaucoma with a single eye injection, which would improve the quality of life for many patients whilst saving the NHS time and money."

The academics are currently in discussion with industry partners to support further laboratory work and rapidly progress this new treatment option towards clinical trials.

Reference: Wu et al. (2020). Gene Therapy for Glaucoma by Ciliary Body Aquaporin 1 Disruption Using CRISPR-Cas9. Molecular Therapy.DOI: 10.1016/j.ymthe.2019.12.012.

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Glaucoma Could Be Successfully Treated With Gene Therapy - Technology Networks

Reversing diabetes with CRISPR and patient-derived stem cells – FierceBiotech

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Insulin injections cancontrol diabetes, but patients still experience serious complications such as kidney disease and skin infections. Transplanting pancreatic tissues containing functional insulin-producing beta cells is of limited use, because donors are scarce and patients must take immunosuppressant drugs afterward.

Now, scientists atWashington University in St. Louis havedeveloped a way to use gene editing system CRISPR-Cas9 to edit a mutation in human-induced pluripotent stem cells (iPSCs) and then turnthem into beta cells. When transplanted into mice, the cells reversed preexisting diabetes in a lasting way, according to results published in the journal Science Translational Medicine.

While the researchers used cells from patients with Wolfram syndromea rare childhood diabetes caused by mutations in the WFS1 genethey argue that the combination of a gene therapy with stem cells could potentially treat other forms of diabetes as well.

Virtual Clinical Trials Online

This virtual event will bring together industry experts to discuss the increasing pace of pharmaceutical innovation, the need to maintain data quality and integrity as new technologies are implemented and understand regulatory challenges to ensure compliance.

One of the biggest challenges we faced was differentiating our patient cells into beta cells. Previous approaches do not allow for this robust differentiation. We use our new differentiation protocol targeting different development and signaling pathways to generate our cells, the studys lead author, Kristina Maxwell, explained in a video statement.

Making pancreatic beta cells from patient-derived stem cells requires precise activation and repression of specific pathways, and atthe right times, to guide the development process. In a recent Nature Biotechnology study, the team described a successful method that leverages the link between a complex known as actin cytoskeleton and the expression of transcription factors that drive pancreatic cell differentiation.

This time, the researchers applied the technology to iPSCs from two patients with Wolfram syndrome. They used CRISPR to correct the mutated WFS1 gene in the cells and differentiated the edited iPSCs into fully functional beta cells.

After transplanting the corrected beta cells into diabetic mice, the animals saw their blood glucose drop quickly, suggesting the disease had been reversed. The effect lasted for the entire six-month observation period, the scientists reported. By comparison, those receiving unedited cells from patients were unable to achieve glycemic control.

RELATED:CRISPR Therapeutics, ViaCyte team up on gene-edited diabetes treatment

The idea of editing stem cells with CRISPR has already attracted interest in the biopharma industry. Back in 2018, CRISPR Therapeutics penned a deal with ViaCyte to develop off-the-shelf, gene-editing stem cell therapies for diabetes. Rather than editing iPSCs from particular patients themselves to correct a faulty gene, the pairs lead project used CRISPR to edit healthy cells so that they lackedthe B2M gene and expressed PD-L1 to protect against immune attack. The two companies unveiled positive preclinical data inSeptember.

Other research groups working on gene therapy or stem cells for diabetes include a Harvard University scientist and his startup Semma Therapeutics, whichdeveloped a method for selecting beta cells out of a mixture of cells developed from PSCs. Scientists at the University of Wisconsin-Madison recently proposed that removing the IRE1-alpha gene in beta cells could prevent immune T cells from attacking them in mice with Type 1 diabetes.

The Washington University team hopes its technology may help Type 1 diabetes patients whose disease is caused by multiple genetic and environmental factors as well as the Type 2 form linked to obesity and insulin resistance.

We can generate a virtually unlimited number of beta cells from patients with diabetes to test and discover new drugs to hopefully stop or even reverse this disease, Jeffrey Millman, the studys co-senior author, said in the video statement. Perhaps most importantly, this technology now allows for the potential use of gene therapy in combination with the patients own cells to treat their own diabetes by transplantation of lab-grown beta cells.

Link:

Reversing diabetes with CRISPR and patient-derived stem cells - FierceBiotech

Glaucoma can be successfully treated with gene therapy – International Business Times, Singapore Edition

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Hackers leak data related to WHO, Wuhan lab and Gates Foundation

A common eye condition, glaucoma, could be successfully treated with a single injection using gene therapy, which would improve treatment options, effectiveness and quality of life for many patients, say researchers.

Glaucoma affects over 64 million people worldwide and is a leading cause of irreversible blindness. It is usually caused by fluid building up in the front part of the eye, which increases pressure inside the eye and progressively damages the nerves responsible for sight.

Current treatments include either eye drops, laser or surgery, all of which have limitations and disadvantages. "At present, there is no cure for glaucoma, which can lead to loss of vision if the disease is not diagnosed and treated early," said study researcher Dr Colin Chu from the University of Bristol in the UK.

For the findings, published in the journal Molecular Therapy, the research team tested a new approach that could provide additional treatment options and benefits. The researchers designed a gene therapy and demonstrated proof of concept using experimental mouse models of glaucoma and human donor tissue.

The treatment targeted part of the eye called the ciliary body, which produces the fluid that maintains pressure within the eye. Using the latest gene-editing technology called CRISPR, a gene called Aquaporin 1 in the ciliary body was inactivated leading to reduced eye pressure.

"We hope to advance towards clinical trials for this new treatment in the near future. If it's successful it could allow a long-term treatment of glaucoma with a single eye injection, which would improve the quality of life for many patients whilst saving the NHS time and money," Chu said. The researchers are currently in discussion with industry partners to support further laboratory work and rapidly progress this new treatment option towards clinical trials.

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Glaucoma can be successfully treated with gene therapy - International Business Times, Singapore Edition

AskBio acquires BrainVectis to expand its gene therapy portfolio – News.MarketSizeForecasters.com

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Asklepios BioPharmaceutical, Inc. (AskBio), a prominent U.S.-based clinical-stage AAV gene therapy firm, has recently announced that it has acquired BrainVectis, a Paris-based gene therapy firm renowned for its work in neurodegenerative disorders, especially on therapies that regenerate brain cholesterol metabolism for patients suffering from Huntington's disease along with other disorders.

For the record, BrainVectis was initiated by Nathalie Cartier-Lacave, M.D., and has support and funding from Sorbonne University, the French Alternative Energies, and INSERM. Currently, Dr. Cartier-Lacave of Atomic Energy Commission (CEA) and her team are concentrating on developing gene therapies that increase the CYP46A1 enzymes expression in the brain.

Evidently, this enzyme is associated with numerous disorders where brain cholesterol metabolism dysfunction is concerned in the neurodegenerations pathology.

Sources cite that AskBio would leverage BrainVectis synthetic and capsid promotor design platforms and its capacity to advance the development of this platform and manufacturing solutions along with other BrainVectis projects.

Speaking on the move, Sheila Mikhail, CEO and Co-Founder, AskBio, said that the companys acquisition of BrainVectis provides it with a remarkable opportunity to work jointly while transforming patients lives.

Huntington's disease is one of the diseases that is irreversible and devastating and presently has no effective treatments. However, BrainVectis in-depth world-leading knowledge of neurodegenerative diseases including Huntingtons disease could allow AskBio to expand its portfolio for these diseases as well.

Prior to this news, AskBio had made headlines when it revealed that it has appointed Don Haut, Ph.D., as its new Chief Business Officer to handle business development execution and strategy.

Reportedly, Dr. Haut has over two decades of healthcare experience and was previously serving to Histogenics Inc. and Sherlock Biosciences as their Chief Business Officer.

Commenting on which, Mikhail said that Don would be a key addition to the company as he holds a wealth of business and strategy development experience within the medical technology and biotechnology fields. His expertise would help the company to effectively advance its existing platforms.

Source Credit: https://www.contractpharma.com/contents/view_breaking-news/2020-04-22/askbio-acquires-brainvectis/

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AskBio acquires BrainVectis to expand its gene therapy portfolio - News.MarketSizeForecasters.com

‘We’re really at a tipping point’: COVID-19 brings research into other medical conditions to a grinding halt – CBC.ca

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Ever since their son Michael was diagnosed with a rare genetic disorder, Terry and Georgia Pirovolakis have been racing to find a cure. They were getting close, and then everything came grinding to a halt.

"We had a whole bunch of researchers around the world doing different things. All of our research has basically stopped," says Terry Pirovolakis.

Michael is two-and-a-half years old and has spastic paraplegia type 50 (SPG-50), a rare neurodegenerative disease caused by a missing gene that is progressively robbing him of his ability to walk.

Over the past year, his parents have raised more than $1 million to help finance a clinical trial for custom gene therapy that promises to halt the disease. But the COVID-19 pandemic has paralyzed research around the world, and their hope along with it.

"It's hard to accept the fact that we were making so many gains," says Georgia Pirovolakis. "You know, we were hoping he would be walking by September."

Michael is just one of the many casualties of the global health crisis. From new gene therapies to help children like Michael, to the latest in cancer treatments, thousands of clinical trials deemed non-essential are on hold.

Brad Wouters is executive vice-president of Science and Research at Toronto's University Health Network, Canada's largest academic hospital. He says an example of the impact is a patient currently being treated for pancreatic cancer.

"He was part of a medical research study here that looked at the underlying genetics of that tumour, and that information revealed a potential new therapy that could be very effective for that patient in immunotherapy. But we only have access to that drug through a clinical trial. And so he won't get it."

Wouters says the only new research happening at the moment is around COVID-19. About 200 of UHN's researchers have pivoted to that, but thousands more risk losing their jobs, Wouters says, because in the past month alone UHN has lost $6 million in industry funding. It's why UHN is asking the federal government for help.

"We've been doing everything we can to try and support these jobs and support this research sector," says Wouters. "But it's over a month now, and we're really at a tipping point where we're going to see significant job losses if something can't be done."

Canada's $3-billion medical research industry relies on that brain trust, much of it made up of international students, says Martha Crago, vice-principal of Research and Innovation at McGill University.

"We wouldn't want to lose this wonderful set of brains coming into our country and helping bring solutions to the public domain," Crago says. "We need to do what we can to keep them."

The pandemic will be over at some point, Crago says, and those researchers will be needed to help regain lost scientific momentum.

Meanwhile, the Pirovolakis family fear they're running out of time.

All the therapies Michael has been doing to maintain the movement he has now, like physical and occupational therapy, have been cancelled. They're trying to improvise at home to keep him moving, and to keep their hope alive too.

The stalled research efforts means a cure for Michael may be delayed for up to a year. That could mean the difference between him ever walking or not.

"It means he's going to degrade," says Terry Pirovolakis. "The progression of the disease is going to kick in, he'll slowly become more and more paralyzed."

It's why the couple are trying to keep research into Michael's gene therapy going.

They're considering using money the family has raised so far to finance early toxicology tests on a potential treatment researchers in the U.S have already developed. They are also lobbying Canada's National Research Council to help develop a treatment or help with funding.

Georgia Pirovolakis says there are so many unknowns, and she can't bear to dwell on them.

"I just look at one day at a time. I'm not thinking about, you know, tomorrow. I'm not thinking about one month from now. I'm not thinking about the research stopping, him potentially not getting cured."

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'We're really at a tipping point': COVID-19 brings research into other medical conditions to a grinding halt - CBC.ca

ThermoGenesis and ImmuneCyte Joint Venture Developing Several Convalescent Plasma and Antibody Therapeutic Approaches Against COVID-19, Featured on…

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RANCHO CORDOVA, Calif., April 24, 2020 /PRNewswire/ --ThermoGenesis Holdings, Inc. (Nasdaq: THMO), a market leader in automated cell processing tools and services in the cell and gene therapy field, announced today that it was featured on multiple new outlets, including a FOX40 news segment titled, "Rancho Cordova Company Says It's Working on Potential Treatment for Coronavirus," regarding the ThermoGenesis and ImmuneCyte joint venture and its research collaborator's efforts toward developing a systemic antibody approaches against COVID-19, ranging from convalescent plasma therapy and polyclonal antibody, to high-affinity monoclonal antibody drug candidates.

Using the rapid IgM/IgG antibody detection technology currently marketed by the Company, along with its own proprietary multi-component automated cell separating system, ThermoGenesis is working towards developing strategies to identify and isolate polyclonal antibodies from the blood of individuals who have recovered from the disease using convalescent whole blood or plasma, which could then be used as a potential therapeutic treatment for patients with of COVID-19.

As previously announced, the Company's joint venture partner, ImmuneCyte, has acquired from its collaborators worldwide intellectual property of four high-affinity monoclonal antibody drug candidates against COVID-19virus. These high-affinity neutralizing monoclonal antibodies were also identified from convalescent whole blood from individuals who have recently recovered from COVID-19.

The FOX40 News is accessible via the link below:

The KCRA3 News is accessible via the link below:

The in-depth local Sacramento Bee news article is accessible via the link below:

Commenting on the recent new coverage Chris Xu, PhD, an immunologist and Chief Executive Officer of ThermoGenesis, said, "We are taking a systematic approach to address several critical unmet needs in the fight against COVID-19, namely rapid tests and effective therapies. By working closely with our global collaborators, we had a head start on this critical research." Dr. Xu also noted that the U.S. Food and Drug Administration is fast tracking therapeutic products related to SARS-CoV-2, which the Company hopes may ultimately include ThermoGenesis' various antibody therapeutic approaches.

Story continues

About ThermoGenesis Holdings, Inc.

ThermoGenesis Holdings, Inc. develops, commercializes and markets a range of automated technologies for CAR-T and other cell-based therapies. The Company currently markets a full suite of solutions for automated clinical biobanking, point-of-care applications, and automation for immuno-oncology, including its semi-automated, functionally-closed CAR-TXpressplatform, which streamlines the manufacturing process for the emerging CAR-T immunotherapy market. For more information about ThermoGenesis, please visit:www.thermogenesis.com.

About ImmuneCyte Life Sciences, Inc.

ImmuneCyte, a joint venture which is 19% owned by ThermoGenesis, develops and commercializes diagnostic and therapeutic technologies for COVID-19. The Company also provides clients the opportunity to bank their own immune cells when the cells are "healthy and unaffected" as a future resource for cellular immunotherapies, such as CAR-T. ImmuneCyte utilizes a proprietary CAR-TXpress platform, a GMP compliant close-system capable of automated separating and cryopreserving different components from blood, simultaneously. For more information about ImmuneCyte Life Sciences Inc., please visit: http://www.immunecyte.com.

Forward-Looking Statements

This press release contains "forward-looking statements" within the meaning of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements are not statements of historical facts, but rather reflect the current expectations of ThermoGenesis concerning future events and results. Forward-looking statements based on ThermoGenesis' current assumptions, expectations and beliefs are generally identifiable by use of words "may," "might," "will," "should," "expects," "plans," "anticipates," "believes," "estimates," "predicts," "potential" or "continue," or similar expressions and involve significant risks and uncertainties that could cause actual results, developments and business decisions to differ materially from those contemplated by these statements. Such forward-looking statements, including statements regarding the intended use of net proceeds from the registered direct offering as well as those factors concerning our expectations, involve risks, uncertainties and other factors, some of which are beyond our control, which may cause our actual results, performance or achievements, or industry results, to be materially different from any future results, performance, or achievements expressed or implied by such forward-looking statements. These risks, uncertainties and factors include, but are not limited to, market and other conditions, as well as those risk factors discussed in Item 1A of our most recent Annual Report on Form 10-K filed with the Securities and Exchange Commission ("SEC") as well as other documents that may be filed by ThermoGenesis from time to time with the SEC, which are available atwww.sec.gov. We undertake no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law. You are cautioned not to unduly rely on such forward-looking statements when evaluating the information presented in this press release.

Company Contact:Wendy Samford916-858-5191ir@thermogenesis.com

Investor Contact:Paula Schwartz,Rx Communications917-322-2216pschwartz@rxir.com

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SOURCE ThermoGenesis Holdings, Inc.

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Gene Therapy Market : Global Outlook and Forecast 2020-2025 – Surfacing Magazine

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ThisGlobalGene TherapyMarketprovides a detailed analysis of theGene Therapymarket based on segmentation such as applications, and geography and forecasts the market for 2020 to 2025. The globalGene Therapymarket is extremely fragmented. The report analyzes the markets competitive landscape and offers information on several field services manufacturers rivaling in the industry. Additionally, thisGene Therapymarket analysis report suggests strategies companies can follow and recommends key areas they should focus on, to make the most of upcoming growth opportunities.

DOWNLOAD FREE SAMPLE REPORT:https://www.fiormarkets.com/report-detail/376052/request-sample

Market Description:

To help clients improve their revenue shares in the market, this research report provides an analysis of theGene Therapymarkets competitive landscape and offers information on the products offered by various leading companies. Although the market share of this segment will decrease, it will continue to dominate the market throughout the forecast years. The market is in the growth phase, as well as the competition is expected to become less intense by the end of the forecast period. It also covers accurate predictions on upcoming trends and changes in consumer behavior and the growth of the industry across the key regions.

TheGene Therapymarket segmentation is based on the regions:North America, Europe, Asia Pacific, South America, and the Middle East and Africa. These regions will witness an increase in their market share and remain the market leader for the forecast period.

It has a detailed analysis of the major industry players to provide insights into their services, business overviews, agreements, key strategies, partnerships, new service launches, and expansions, collaborations and the competitive landscape associated with theGene Therapymarket. The analysis contains the key industry players:Spark Therapeutics LLC, Bluebird Bio, UniQure N.V., Juno Therapeutics, GlaxoSmithKline, Chiesi Farmaceutici S.p.A., Bristol Myers Squibb, Celgene Corporation, Human Stem Cell Institute, Voyager Therapeutics, Shire Plc, Sangamo Biosciences, Dimension Therapeutics and others.

BROWSE COMPLETE REPORT AND TABLE OF CONTENTS :https://www.fiormarkets.com/report/global-gene-therapy-market-by-type-germline-gene-376052.html

Exploring the Growth Structure of The Market:

The report contains detailed information on factors that will accelerate the growth of the market during the forecast period from 2020-2025 along with the CAGR of the market during the forecast period. However, comprehensive details on factors will challenge the growth of companies rivaling in the market. It consists of a precise estimation of the globalGene Therapymarket size and its contribution to the parent market as well as a thorough analysis of the markets competitive landscape and detailed information on several vendors.

It comprehensively segments theGene Therapymarket and provides the closest approximations of the revenue numbers for the overall market and its sub segments across major regions. It would help stakeholders understand their competitors better and gain more insights to enhance their positions in theGene Therapymarket. The competitive landscape section includes a competitor ecosystem, new service developments, partnerships, and acquisitions. It would help stakeholders understand the pulse of the market and provide information on the key market drivers, restraints, challenges, and opportunities.

Contact Us:Mark StoneSales ManagerPhone: (201) 465-4211Email:sales@fiormarkets.comWeb:www.fiormarkets.com

View More Information onGene TherapyMarket :https://www.marketwatch.com/press-release/global-gene-therapy-market-2020-overview-manufacturing-analysis-development-status-competitive-analysis-to-2025-2020-04-21

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Gene Therapy Market : Global Outlook and Forecast 2020-2025 - Surfacing Magazine

Charlotte de Witte bridges the gap between Techno and Trance with two-part remix treatment of Jerome Isma-Ae’s ‘Hold That Sucker Down’ -…

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MUMBAI: There arent a lot of artists out there who can turn one of dance musics greatest classics into a genre-crossing masterpiece, but Charlotte de Witte is clearly one of them and has outdone herself once more. Today, the widely acclaimed Techno starlet presented not one but two brand-new renditions of Jerome Isma-Aes Hold That Sucker Down, with both the Rave Remix and Trance Remix set to appease Techno lovers and Trance enthusiasts alike.

Already played by Armin van Buuren during his A State Of Trance 950 warm-up set, Charlotte de Wittes remix of Hold That Sucker Down is a timeless classic turned contemporary crowd favorite. Turning Jerome Isma-Aes spin on The O.T. Quartets 1994 original into a nostalgia-infused floor-thriller, the Belgian tastemaker does what she does best: crafting up records for the sole purpose of dance floor domination.

Charlotte de Witte: Remixing a classic is something that always feels extremely honorable and rewarding to me. While remixing Jerome Isma-Ae, I decided to aim for two different remixes. One would respect the massive trance lead and vibe of the original, while the other would be faster and more stripped down, bringing forward the techno that I love so much.

Charlotte de Witte is a DJ and producer whose surge on the scene has resulted in her being one of the most sought-after names in electronic music today. With highlight performances across the globe, Mixmag and DJ Mag covers, high-ranking positions in a multitude of charts and lists, and her ownership of one of the strongest social media profiles in music today, she confirms her status as a nouveaux techno royalty on a day-to-day basis. Through her boutique label KNTXT, label head Charlotte de Witte organizes events, releases music and curates radio shows with no intention of slowing down, showing to all that she is quite the force to be reckoned with.

The Rave and Trance Remix of Jerome Isma-Ae Hold That Sucker Down (Charlotte de Witte Remix) are out now on Armada Music.

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Charlotte de Witte bridges the gap between Techno and Trance with two-part remix treatment of Jerome Isma-Ae's 'Hold That Sucker Down' -...

20 Questions With Paul van Dyk: The Trance Icon on Growing Up in East Berlin & Why Social Distancing ‘Is Incor – Billboard

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Paul van Dyks name is synonymous with trance. A pioneer of the genre before it even had a name, the German producer and DJ established its characteristics with his early productions and remixes. Most notable of these is his track, For An Angel, and his remix of Humates Love Simulation at the start of the 90s.

With these productions and the rise of Stateside DJ culture, van Dyk shifted into international superstardom. Forbes named him one of the worlds greatest DJs in 2012. He occupied a top 20 spot in DJ Mags Top 100 DJs for 15 years, hitting No. 1 twice, in 2005 and 2006. When the Grammys introduced the best electronic/dance album category in 2005, van Dyks Reflections was nominated. (He won a Grammy in 2008, for his remix contribution to The Dark Knight soundtrack, which won best score soundtrack album for motion picture, television or other visual media.)

In the past 16 years, van Dyk has released nine artist albums and sold millions of records. His 10th LP, Guiding Light was set for release this spring, but due to the pandemic, van Dyk is instead releasing his fifth remix album, Escape Reality.Many years in the making and out on his own longstanding VANDIT Records,Escape Reality reimagines some of van Dyks most memorable songs into non-dancefloor versions better suited to the at-home listening audiences are presently confined to.

During quarantine, Van Dyk has also been giving fans a weekly livestream -- Sunday Sessions, at 7 p.m. CET, from his home in Berlin. This program is in addition to van Dyks VONYC weekly show on Dash Radio, which recently passed its 700th episode.Upon the release of Escape Reality, van Dyk discusses growing up in East Berlin, the resurgence of trance and shifting gears in these unprecedented times.

1. Where are you right now and what is the setting like?

In Berlin, at home, in my home office/studio, cant go anywhere. Im in a different room than where I do the livestreams -- but its in the same, lets say, facility.

2. What was the first album or piece of music you bought for yourself and what was the medium?

I grew up in East Germany, but my grandma was allowed to travel to the West. She smuggled a record back for me. It was the vinyl album of Orchestra Manoeuvres in the Darks [1980 synth-pop album]Organisation. It was extremely influential. Early electronic, but also melodies and poppy elements, the general imprint of what later came for me in music.

3. What was distinctive about where you grew up and/or where you spent the specific years that shaped you as a musician?

Where I lived in East Berlin was 600 meters away from the Berlin club, UFO. The Berlin Wall was between me and the club, which created a certain hunger to experience this music live. I was listening to the radio all the time and hearing about whats going on in the clubs in West Berlin, and I could never go. That energy and that vibe definitely had an impact on me. Music wasnt just a sound I was excited about. It was also the gateway to a free society for me. Listening to this music behind the Iron Curtain connected me to the world.

4. What did you parents do for a living when you were a kid and what do they think of what you do for a living now?

My mom was an interior designer. I had an apprenticeship in East Germany as a broadcast technician, which stopped when we moved to Hamburg when I was 17 and I started an apprenticeship as a carpenter. My mom raised me very grounded, to have a proper profession, to have a job. When I told her Im not going to do this carpenter thing anymore, Im going to do this music thing, she said she trusted me. The way she raised me, she was sure I wouldnt do this lighthearted.

5. What was the first track you made?

It was a remix for a project called Effective Force called Illuminate the Planet in 1993. The remix was called New World Order Mix, because I was a fan of New Order and because it was two years after The Wall went down and everything was different. My first own track is called My World in 1994. To me, all music fills the room. Trance music goes through the world, all the way to the horizon. Maybe that has to do with where I grew up and how I grew up. When you grow up in a confined space, the world and the universe is what you dream of.

6. What was the first thing you bought for yourself when you started making money from music?

I didnt have any money at all, so when I was booked to play my first paying show, I went to the promoter and asked him if he could pay me some of my fee upfront so I could buy some more records to play a better set.

7. What was your first ever gig?

At Tresor in Berlin. I wasnt paid for that. I was just invited to play in the beginning when nobody was there. That was my first gig in front of a few people. But my first real booking was at a club called Turbine in Berlin.

8. What moved you toward dance music as far as a particular club, party or raving experience?

When I was a kid, I used to listen to the West Berlin radio stations when I did my homework. When I heard The Smiths for the very first time, I thought, Wow, this is awesome, its so different. At the same time, I had this taste for electronic-sounding stuff like OMD and Depeche Mode and Yazoo. I started to listen to specialized radio shows and heard stuff we would call early house music. It was interesting, because there wasnt actually anyone singing and telling you to be sad or to be happy or whatever the lyrics might say. It was the instrumentation and the energy that moved me. That was so exciting to me, especially since I didnt speak any English anyway -- we learned Russian in school in East Berlin -- so I didnt understand what they were saying.

9. Do you remember how it felt when you got a reaction in terms of people actually dancing?

My first emotional memory is fear. I was a typical bedroom DJ. I was at home, never turning the music up really loud, turning the bass down. Then suddenly I was in the club, where I heard the same records very, very differently. I heard all these things that I was never able to hear before at home. It was frightening. The thing was, I believed so much in the music that I was playing that I didnt doubt that people would like it. At that age, when youre just beginning, youre so nave, you think this is the best music ever, everybody must love it. Until you realize a lot of people have different tastes and different approaches to things. No one left the club when I was playing. That made me happy and gave me hope.

10. If you had to recommend one album for someone to get introduced to dance music, what would you give them?

Gargantuan by ['90s progressive house duo] Spooky. They laid a phenomenal groundwork with this album in regards to sound and a different approach to music. Its a very inspirational record. In regards to production, BT Ima is phenomenal. It was because of that album that we got introduced and made music together.

11. What was the last text message you sent and to whom?

The last text message I sent was to my IT guy because one of my software plugins wouldnt work. There are these programs where you can remotely log into the studio system and go on to the computer and see the problem. I wanted to see if he could do that.

12. You were originally scheduled to release a different album, Guiding Light, this spring. What was the idea behind releasing the ambient remix album, Escape Reality, instead?

I was finalizing everything for Guiding Light, and at the same time, the lockdown became more and more intense. Im banging 138 BPM. Im really excited. I would love to go out on the weekend and play in front of people, see their reaction, but its not possible when everyone has to stay home.

Im a huge fan of straightforward club music, but thats not necessarily what Im listening to right now. I thought it would be a good moment in time to finish the Escape Reality project and release it now when people are posted at home and actually listening to and enjoying music. Releasing club music right now is like going fishing in a pond where there are no fish. You throw the bait in, but it cant be consumed when there is nothing there to consume it.

13. What was your intention with the creation of Escape Reality?

I compose a lot of music on keyboard or guitar with proper songwriting. In the clubbing context, sometimes the actual song is undermined by the electronics of the music. I wanted those tracks to feel like individual parts of the composition rather than the energetic vibe. Someone like Luke Howard or Niklas Paschburg, who make very reduced piano-based, electronic-influenced music that is meant to be sat down and listened to -- I find really inspiring, and thats what I tried to achieve.

14. What effect do you hope the album has on people during this specific point in time?

As the title says, maybe a little escape. Maybe sit and look out of the window and listen to the music and get some hope. It will be better. We just have to be patient. We have to get through this together. Maybe the whole album, or just one or two tracks will become something that give that little glimpse of hope in rather miserable times.

15. The general opinion is that this is a productive time for making music, without knowing when, or if, your music will ever be released. Does that feel true for you?

I would make music without it ever coming out. Thats one of the reasons why Escape Reality took so long. I was working on it whenever I felt like it. I finished each individual track without ever having a plan about if its going to be released or when it will be released. Every artist is different, so every approach to art is different.

16. Youve had your tour dates postponed indefinitely. What are some impacts of these changes?

The uncertainty, not just for me, but for everyone, is whats nerve-racking. For example, in Germany yesterday they said there are no big events allowed until the 31st of August. The next sentence was: "then we will see." It doesnt give you anything. The only way to stay sane is to be active and communicative. The term social distancing is incorrect. We have to distance ourselves physically, but, if anything, we should socially stay far closer together these days. We should be there for each other and communicate with each other.

17. You do a weekly livestream, Sunday Sessions. What do you hope your fans will get out of these?

My main aim for the people on there is that they all communicate with each other. They all logged on together, at the same time, a big community that is together, connected through the music. Im just the vehicle they use to communicate through and be together. Playing music is the only thing I can do right now and through that create a communication platform. It feels good to see people from all over the world talking to each other.

18. Youve always been active and articulate about politics. How do you feel you can use your position to create awareness and have influence?

The complexity of the world and especially the political decision-making process needs much more than [the number of characters you're allowed] on Twitter. It doesnt make much sense these days to use social media to make a statement. First, you will be ripped apart. No one takes the time anymore to really think twice about why I may have made a statement and what led me to think in a certain way. It seems that the world is conditioned to no longer read. I learned that it makes more sense to connect behind the scenes with politicians and decision makers to work on changing things and initiate a positive thinking process.

19. As a trance pioneer, what are your thoughts on its recent resurgence?

Trance was never gone. I love this music, and I listen to it every day. I hear all the amazing up-and-coming talent. To me, its still the most creative electronic music form -- because artisticallyyou have to be able to bring an idea across through a composition, not just a soundscape that is created by plucking on a filter. You have to be able to play a melody, to play chords and also to produce. It takes much more from someone to make this kind of music.

It goes back to my nave way of thinking when I started: "I love this music so much, everybody must love it." Its good for the musical genre as a whole that its coming back and gaining more popularity again. A young kid who starts making trance music, its not the latest, super-duper-popular stuff. They know theyre in a niche, and you know theyre in it for the music.

20. What piece of advice would you give to yourself at the beginning of your music career?

Dont take disappointment too close to heart. If youre a passionate musician, if youre a passionate DJ, one way or another, you will run into a situation where somebody rips you off or sidelines you or does other things to you. Dont take it to heart, and believe in your music.

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20 Questions With Paul van Dyk: The Trance Icon on Growing Up in East Berlin & Why Social Distancing 'Is Incor - Billboard

Above & Beyond’s Tony McGuiness re-creates the first episode of ‘Trance Around The World’ – We Rave You

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Tony McGuiness, British DJ and producer, one third of Above & Beyond, has shaken up the trance community with some amazing news last week. He announced that he will be recreating the very first episode of the signature Trance Around The World radio show, that aired for the first time in 2004. Livestreams have recently replaced parties and festivals due to the Coronavirus pandemic. Artists from all around the world are currently transforming their bedrooms and living rooms into trendy club settings and entertaining fans with their amazing performances.

Tony McGuiness took his time and prepared a special two hour set, mixing the original tracklist of the first Trance Around The World radio show on his Twitch account. Apparently the original episode was just a test broadcast and the tracks were unmixed and separately trimmed out in a playable list. Somehow Tony managed to save it on his card, just in case they might do something with it. It was streamed back in January 13th, 2004 onMinistry of Sound Radioand was never recorded or archived, so the re-do that McGuiness did was highly appreciated.The weekly Trance Around The World show aired between 2004 and 2012, attracting approximately 35 million listeners from more than 35 countries.

He started out this memorable set with a nostalgic remake of OceanLabs track Satellite, nicely mixing it into Filo & Peri Bangin Mix of Whirpools Under The Sun. Some other highlights of the set were definitelly Above & Beyond remix of Chakras I Am, Robert Nicksons remix ofEndresKallocain, Super8s Alba, Gabriel & Dresdens mix of Sarah McLahlans Fallen, Envios Touched By The Sun and much more. The full tracklist of the set can be found here.

TATW 001 was definitely a very important milestone for Above & Beyond, now the re-creation set is finally here and people can enjoy this masterpiece anywhere and anytime. Tony also hinted that he might be bringing back theTrance Around The World 002 next week, but for now we will just have to wait and see what happens.

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Above & Beyond's Tony McGuiness re-creates the first episode of 'Trance Around The World' - We Rave You

Charlotte de Witte Showcases Two Sides of Her Production Abilities With ‘Hold That Sucker Down’ Remixes – CULTR

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Widely acclaimed Techno starlet Charlotte de Witte presents not one but two brand-new renditions of Jerome Isma-Aes Hold That Sucker Down. The two versions come in the forms of a Rave Remix and Trance Remix set to appease Techno lovers and Trance enthusiasts alike.

Charlotte de Witte: Remixing a classic is something that always feels extremely honorable and rewarding to me. While remixing Jerome Isma-Ae, I decided to aim for two different remixes. One would respect the massive trance lead and vibe of the original, while the other would be faster and more stripped down, bringing forward the techno that I love so much.

Turning Jerome Isma-Aes spin on The O.T. Quartets 1994 original into a nostalgia-infused floor-thriller, the Belgian tastemaker does what she does best; crafting up records for the sole purpose of dance floor domination. Charlotte de Witte has further solidified herself as one of the most exciting techno projects right now and with these remixes, she has expanded her artistry to Armada and their fans, especially with her trance mix.

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Charlotte de Witte Showcases Two Sides of Her Production Abilities With 'Hold That Sucker Down' Remixes - CULTR

Trivecta Discusses the ‘Everyday’ EP and Connecting with Fans – EDM Identity

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It is hard to ignore the sheer talent that is Trivecta. This Florida-based producer has an incredible work ethic that shines bright with the number of genres that he is able to produce. Incorporating influences from melodic dubstep, trance, and drumstep theres no limit to the creativity he expresses in his music. Now, on the Everyday EP, Trivecta takes listeners on a journey and lets them in on his new genre he has coined called folk bass.

While he had blown away his fans with tracks like Island and Oxygen as of late, its clear that Trivecta saved his best production for his debut EP.Through the four tracks that make up this project he takes listeners on a journey filled with indie-folk chords and melodic bass-infusions, its something fresh, to say the least.

The intro track and Leave It All Behind is the perfect example of this new genre Trivecta has coined for himself. While Wasteland and Everyday fuse emotional vocals with thumping dance basslines. This EP is something that will instantly connect with old fans and new ones alike!

Ahead of the EP, Trivecta chatted with us about his process making the EP, his take on approaching collaborations, and his take on the Marvel Comic Universe films. So listen to Trivectas Everyday EP on Spotify below, download or stream the EP on your favorite platform, and read on for an interview with Trivecta himself!

Yeah! It actually differed a lot, thats a great question. For a long time, I have been in the melodic bass sphere. I felt that it was really fresh when it came out melodic bass music. But I feel like even in the past couple years, it could use a little burst, a little fresh injection of influence. Personally, I had been listening to a lot of indie-folk music like Of Monsters and Men and Mumford & Sons. I thought to myself, dude! This music is very immersive, this music takes me somewhere. Just like trance and melodic bass take me somewhere. There has to be a middle ground here!

That was the starting point of how I could figure out how to start to mold something that folks felt uniquely powerful. That laid the blueprint for this EP to be made.

It differs from track to track on the EP, but to answer your specific question about Leave It All Behind. I had been touring a lot (RIP touring for now) and started to get this feeling it was the first concentrated batch of touring that I had done on my own. You would be sort of nostalgic when youre out on the road, really far from home.

Sometimes those songs in the airport that they play over the speaker can be a little bit more effective when you havent seen your friends in a while. And I would hear some of this folk music on the radio in the airports actually, and there was actually one song I kept hearing at Tampa International Airport. I think it was by Manchester Orchestra. It just had this big acapella vocal hook, this big stack of vocals super nostalgic and super powerful and I was like man I want to do something like that! That sort of informed how I incorporated those influences in Leave It All Behind.

As far as collaborations for example, Wooli came at me and he was so pushy. He was like lets make something, lets make something. Finally, we got something together and that was one of my first real collabs I had done. Hes a really easy guy to collab with. Ever since then it has been easier. Its fun, man!

Seven Lions has been great to work with, we have a couple of other ones we are working on. A lot of the Ophelia artists are sort of cross-pollinating during this quarantine, so there will be a lot more collabs for sure.

I would love to work with Of Monsters and Men and Mumford & Sons in the future!

So Wooli had been working with a lot of stuff with Excision at the time, who I did not know personally yet. And Wooli and I started working on the tune Oxygen since he found the vocal for the tune, which was really nice. He was working on a bunch of stuff with Excision and he had a bunch of ideas for the tune too and we decided to work on the whole thing together. That was a pretty easy one to get done, that was one of the easier wrap-ups I have had for a tune. Everybody was on the same page. We all contributed and made it work!

Yeah, I do! There are a few things. One is whenever I start feeling inspired, I try to jot down a lot of sketches, rather than okay Im inspired, Im going to start one song and only work on one song. At any given time, I have at least a good ten tracks that I am actively thinking about or trying to get done. So if I have writers block, its like I am not coming up with anything creative, but I have songs that need tending to. I have songs that need to be tightened better, I have songs that need to sit better sonically, I have songs that need sound replacement. Things like that.

Another thing if I have writers block I will find music that really just inspires me. Especially if it is not EDM and just listen to it and find inspiration. Usually, something will come from that eventually.

There have been a few. Honestly, there are some that are more concrete. Like one was getting the hang of playing live shows. I went from a place where I thought I had all this cred, I had half a million listeners at the time online, but I would go play shows and no one knew who the hell I was. Thats when I realized its totally different spheres. That was definitely a big challenge to overcome that.

Lately, a struggle I have been having is the quarantine and finding creative ways for this EP to have its time of day and get its legs and is able to create experiences with the fans. Another one that feels overarching is the struggle of when you start off making live music online and you do not actually see these people. It can start to feel disconnected, for a while Trivecta and me, Sam, were such wildly different things. I was portraying a different person online and I didnt know any of my fans personally and it was all very disconnected. Im a goofy dude and the music was very serious, I didnt know how to connect the two, but lately more so things have been a lot more connected where it all feels like the same thing. Where people can go yeah hes a goofy dude, but the music is serious and thats okay. Through communicating with the fans at shows and online everything feels a lot more connected than ever. Thats been a struggle thats lately been a lot more together.

It feels like as soon as this all happened, I figured I was going to start streaming. Im a guitar teacher by day so Im used to communicating about music with people. So I figured I was going to set up everything Twitch, Discord, OBS.

Through doing that and going through unreleased tunes that I dont want to put out because they are so wildly different from what I do and showing my fans them on stream and they are like yo, we love this! My fans are already seeing that side, so I feel a lot more connected with them just about the material itself. Even through Discord and talking with them all the time and through streaming and talking with them all the time. Especially even with the Ophelia label group all of us have this WhatsApp and we chat all the time. So I feel closer to all of my close artist friends as well.

Its completely changed a lot of things, but some things are still the same. For example, we are still moving forward with the EP and we are still putting all of that out. It feels weird to feel like I just have arrived at this unique folk bass and Im putting it out there in the middle of a pandemic. Im not able to tour around it, unfortunately.

So everything has been clearly disrupted, but I think an interesting caveat to all of this, is that the board is shifting and the playing field is changing. I think that we may find that artists who have something to offer, whether its their personality or artists who are more focused on creative music versus artists who maybe arent making their own music and are just out there throwing parties every night and are now like oh no, what do I do now.

I feel like a lot of us are more engaged in the music and more engaged in the content. As long as they are down to communicate to the fans, I feel like guys like us are in a position to come out of this whole thing in better relative standing than where we started. Rather than trying to compete with all of these guys who are throwing parties every night, we may be able to leverage our creativity, music, and content during this time and give people things that they can connect with. Turn this into a net positive.

Oh, man! My secret okay, there are a couple of things. I like to get thick steaks because then I can really focus on how I want the middle to be cooked, compared to the outside. I need to get my middle to a nice medium rare and a hard sear on the outside and not compromise either of them.

Honestly, another secret is. and people sleep on this a damn good meat thermometer! People talk down on meat thermometers and youll find purists that dont like them and to me, its like producing music without using visual guides like spectrum analyzers. Every producer uses that stuff because it gives you another way of understanding what it is that you are doing. Meat thermometers are so cool because it allows me to know what temperature different parts of the steak are at. Thats great because I can really sear hard and not have to worry about all of that.

It also starts with the cut too! You have to select a nice cut. My favorite cuts to cook are typically a rib-eye or a filet or a strip. I love the fat content of the rib-eye. I love strips for sharing with people. I love a good filet because they are just so tender. It depends on the context!

I wasnt actually. I had no interest until I sprained my ankle and was in bed for a while. Then I figured I was just going to watch all the MCU (Marvel Comic Universe) movies and just see what this is about. As I was watching though I was like okay this good.okay this is pretty good.okay this is good! I was really buying in, but let me tell you, by the end, by the Infinity War and Endgame I was like dude! This is the craziest thing I have seen in my entire life. When I saw Infinity War and Endgame, it had completely validated everything I had seen.

To me it was the anti-Game of Thrones, I was so obsessed with GoT, but it was so clear they were trying to figure out what they were trying to do at the end. Whereas MCU, you really got this sense they knew where they were going. Everything led to that ending. I have never felt more engaged by any sort of media content as I felt watching Infinity War and Endgame.

After watching all of that, I would say its tough, I would say out of all of them I like a few of them for different reasons, but I would say the character whos lore and the world they live in I like the most would be Thor. I love Norse folk mythology and sort of having that aspect intertwined in the Thor universe I felt was really cool. Im a big Scarlet Witch guy too!

Oh, thats a good question. Let me think..dont leave it all behind! [Laughs]

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Trivecta Discusses the 'Everyday' EP and Connecting with Fans - EDM Identity

Quarantine curation: 12 new regional films that made it to streaming platforms – India Today

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The pandemic has brought our lives to a standstill and it might be a while before we could freely step out of our homes. The probability of spending our next few weeks indoors is high and, by now, many of us have lost our cool.

Thankfully, the online streaming platforms are dropping new releases every week, which you would have missed catching up in theatres this year. Some films, despite having good content, were not fortunate enough to have a long theatrical run. However, they are now available on OTT platforms, reaching a wider section of the audience.

We have compiled you a list of 12 new South Indian films, available on various streaming platforms, that might help you cheer up in quarantine. All these films made it to the big screen in 2020 - a few days before the shutdown.

Tamil

Film: Kannum Kannum KollaiyadithaalWhere to watch: Netflix

Two con artists fall in love with orphan girls and decide to settle down with them after performing one last heist. Trouble begins when they discover the identity of the women in their lives. Directed by Desingh Periyasamy, the film is a promising entertainer with some clever writing.

Here's the trailer:

Film: Dharala PrabhuWhere to watch: Amazon Prime

A fertility clinic doctor forces a young happy-go-lucky guy to take up the job of a sperm donor. Things fall apart when his life partner learns about his profession. Dharala Prabhu is the faithful Tamil remake of hit Hindi film, Vicky Donor. The film features Harish Kalyan and Tanya Hope in the lead roles.

Here's the trailer:

Film: DarbarWhere to watch: Amazon Prime

Adhithya Arunachalam, a ruthless cop, goes on a mission to clean up the drug mafia in Mumbai city. The process leads him to an unsolved case that shook the police department in the 90s. Starring Rajinikanth and Nayanthara in the lead, the film is a commercial cocktail of action and drama.

Here's the trailer:

Film: Oh My KadavulaeWhere to watch: Zee 5

A young man, who marries his childhood friend, lands in a family court asking for a divorce. What happens if he gets a golden ticket that helps him to rewrite his fate? Directed by debutant Ashwath Marimuthu, the film is a heartwarming love story with enjoyable moments.

Here's the trailer:

Telugu

Film: World Famous LoverWhere to watch: Netflix

A struggling writer, who gets dumped by his girlfriend, creates a world of his own and pens down some emotional love stories. His thoughts make him realise the mistakes he had made and repent for it. Directed by Kranthi Madhav, the film has Vijay Deverakonda in the lead.

Here's the trailer:

Film: MadhaWhere to watch: Amazon Prime

A proof-reader falls in love with a cinematographer unknowing of his devious plans. Can she escape the trap laid by him? Madha is a gripping thriller directed by Srividya Basawa. The film has won appreciations among the audience.

Here's the trailer:

Film: Ala VaikunthapurramulooWhere to watch: Netflix

Valmiki swaps his newborn baby with his boss Ramachandran's baby in a hospital. However, after 20 years, Bantu, who grows up in a middle-class family, realises that his real father is a multi-millionaire. What happens next form the crux of the story. The film has a little bit of everything - romance, action, comedy and emotions. Directed by Trivikram Srinivas, Allu Arjun plays the lead in the film.

Here's the trailer:

Film: Sarileru NeekevvaruWhere to watch: Amazon Prime

An army officer decides to confront a corrupt ruthless politician after realising that his colleague's family is in trouble. This Mahesh Babu's film is a commercial potboiler that often ladles out doses of patriotism. Directed by Anil Ravipudi, the film features Rashmika Mandanna as the female lead.

Here's the trailer:

Malayalam

Film: TranceWhere to watch: Amazon Prime

A motivational speaker, who loses his younger brother due to mental illness, takes up the job of a pastor to mint money. However, one of his live interviews on television puts him under trouble. Trance, is a psychological thriller, with some brilliant performances. Fahadh Fasil, Nazriya Nazim and Gautham Menon play the lead roles.

Here's the trailer:

Film: Varane AvashyamundWhere to watch: Netflix

Varane Avashymund is a feel-good film that revolves around the story of a single mother and her daughter. It's about how their lives take a turn after meeting a youngster and a middle-aged man who resides in their apartment. Directed by Anoop Sathyan, the film is Dulquer Salmaan's first production venture.

Here's the trailer:

Kannada

Film: DiaWhere to watch: Amazon Prime

Dia, a pretty young girl, falls head-over-heels in love with her college senior. However, her introverted nature puts her relationship in trouble. Would it be possible for her to move on from her past? Dia is a well-crafted film, with a lot of surprises in store for you.

Here's the trailer:

Film: Love MocktailWhere to watch: Amazon Prime

After rescuing a woman, Adi reminisces about his love life and tells her about all the heartbreaks he has endured in his quest to find true love. This film is fun-ride and lets us forget our own problems in life.

Here's the trailer:

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Quarantine curation: 12 new regional films that made it to streaming platforms - India Today

Glide Into the Weekend With Steny and Replay M’s Pulsating Deep House Single "Nightshift" – EDM.com

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Rising comboStenyand Swiss producerReplay Mhave joined forces for "Nightshift," an anthemic deep house tune out via Karonga Records.

With its pulsating bass lines and spacey pads, "Nightlife" is a hypnotic house number that harkens to the dark bliss of late-night Ibiza club revelry. Steny and Replay M did a fantastic job of maintaining the energy throughout, introducing subtle production techniques as the arrangement progresses. Crisp leads and driving, trance-inspired plucks take over after the break, building tension before eventually culminating in a synth-laden second drop, which is a refreshing change of pace on the one that precede it.

The two members of the Steny tandem are based in Switzerland and South Africa, respectively, but the artists collaborate frequently, building a unique chemistry over the years. This eventually led to a landmark signing with progressive house and trance heavyweightArmada.Their music has been supported by a slew of the industry's biggest players, includingLost Frequencies, Morgan Page, Lucas & Steve, and EDX, among many others.

International DJ Replay M has made a splash on the scene as well, making performances at The Street Parade, Openair Gampel, Oceanbeat Boat Ibiza, and Braslav Festival, among other notable shows. He has also received support from a number of electronic bigwigs, like Kris Kross Amsterdam, DJ Scene and Jan-Christian Zeller.

Facebook: facebook.com/stenymusicInstagram: instagram.com/stenymusicSoundCloud: soundcloud.com/steny-music

Facebook: facebook.com/djreplaymInstagram: instagram.com/replaymSoundCloud: soundcloud.com/replaym

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Glide Into the Weekend With Steny and Replay M's Pulsating Deep House Single "Nightshift" - EDM.com

Looking for options other than Holly, Bolly and Tolly to stream this lockdown? – Telegraph India

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From class conflict and hierarchy inSaurabh Bhave's Bonus, to Dia, athe mind-bending psychedelic trip of Trance, here are our picks:

Language: Telugu

Streaming on: Amazon Prime Video

An edge-of-the-seat watch, this February 2020 release ticks all the thriller boxes murder, mystery and macabre. Directed by newcomer Sailesh Kolanu, Hit stars Vishwaksen Naidu as a dynamic cop called Vikram who is battling post-traumatic stress disorder after an incident in his past has left him permanently scarred. The 128-minute box-office winner an acronym for Homicide Intervention Team, which Vikram is a part of starts off with a girl going mysteriously missing and then spins off into a rollercoaster ride that forces Vikram to confront his own demons.

Hit works because it remains taut for the most part, oscillating between a Se7en-styled investigative thriller and a police procedural, and doesnt pull any punches when it comes to showing stomach-churning stuff. The end may or may not work for you but the money shot in the films final moments sets the tone for at least a sequel, if not more films in the Hit franchise.

Language: Tamil

Streaming on: Amazon Prime Video

Released in theatres on the second Friday of March this year, the Tamil remake of Shoojit Sircars Vicky Donor has Harish Kalyan stepping into Ayushmann Khurranas shoes to play a young man who teams up with an infertility expert to turn into a sperm donor. Largely operating on the same beats as the 2012 Bolly original, Dharala Prabhu introduces minor tweaks in its plot and players in accordance with its milieu, but retains the froth and freshness that marked Vicky Donor. The film benefits from the comedic chemistry between Harishs Prabhu and Vivek (who plays Dr Kannadasan) and works, despite a meandering second half, on the strength of its light-hearted and optimistic look at taboo topics like infertility and sperm donation.

Language: Telugu

Streaming on: Netflix

Hitting theatres on Valentines Day this year, World Famous Lover as is evident from the title has heartthrob Vijay Deverakonda playing an intense lover, similar to the retrograde rebel he essayed in his breakout film Arjun Reddy. World Famous Lover that also stars Raashi Khanna and Aishwarya Rajesh, encapsulates many love stories in one and transitions between fantasy and reality, albeit with inconsistent results. Though the intention is clear the film strives to focus on the selflessness of love as seen through different characters in different circumstances the execution of what must have been a great idea on paper isnt as seamless. But whats not to love about a love story, especially in these times, and one which showcases the ever popular Deverakonda in a role he can now possibly play with his eyes closed.

Language: Marathi

Streaming on: Amazon Prime Video

Class conflict and social hierarchy explored winningly in the multiple Oscar-winning film Parasite is also the driving force behind Bonus, that hit theatres in end February. Saurabh Bhave directs this big story of small moments that tells the story of young Aditya (Gashmeer Mahajani) who accepts his grandfathers challenge of giving up his lavish life and living on meagre means after he refuses to pay bonus to his employees. A critique on class divide, Bonus works largely within the format of a fun watch, combining humour and romance. Though formulaic in parts, the film scores big on relatability.

Language: Malayalam

Streaming on: Amazon Prime Video

One of the most talked about films in recent times, Trance should make it to your watchlist simply for the fact that its frontlined by Fahadh Faasil. The actor whose given us films like Super Deluxe and Kumbalangi Nights is sensational in Trance. The February film a mind-bending, psychedelic trip that traces the transition of a small-time motivational speaker (Viju, played by Fahadh) into a televangelist who performs hoax miracles and helps his business grow into a global phenomenon Trance starts off strong and becomes increasingly shaky, but we recommend you catch it for Fahadhs uninhibited central act. Directed by Anwar Rasheed, Trance falters in parts the ending lacks a satisfactory payoff, especially given the film runs at a butt-numbing 170 minutes but is an avant-garde piece of filmmaking that deserves at least a one-time watch.

Language: Gujarati

Streaming on: Amazon Prime Video

If an easy-breezy watch is what you have your eye on, then look no further than this feel-good Gujarati film that traces its young protagonists rollercoaster ride through multiple relationships before he discovers the true meaning of love. Scoring big in the departments of music and cinematography, Luv Ni Love Storys is powered by Pratik Gandhis (who plays Luv) natural charm and a strong supporting cast that bring on the laughs as easily as tease a tear out of the viewer.

Language: Malayalam

Streaming on: Amazon Prime Video

Resting on a dialogue-driven narrative where the verbal is as impactful as the visual, this Malayalam film has Prithviraj and Biju Menon scorching the screen as sparring partners in this duel of ego and one-upmanship. A compelling look at misplaced machismo and toxic male entitlement, Ayyappanum Koshiyum the title is drawn from the names of the characters played by the two men in the middle released in February and received unanimously positive reviews, with critics praising it for its sharp story and its ability to engage the viewer consistently without resorting to gimmicks. Give the film a watch if you are a Prithviraj fan. And even if you arent.

Language: Tamil

Streaming on: Amazon Prime Video

Translating to burden in English, Baaram has received widespread critical acclaim, including a National Award. The mysterious death of a night watchman forms the bedrock of the February film both real and relevant directed by Priya Krishnaswamy, who also does the writing and editing duties here. Baaram doesnt lose sight of its strong emotional core despite its documentary-style look and feel. The film lays bare the practice of Thalaikoothal, a type of euthanasia that still has social sanction in some parts of Tamil Nadu. Fashioned as a thriller in parts, Baaram runs at a pacy 90 minutes and should make it to your watchlist if you are looking for something more than the usual light-hearted fare.

Language: Malayalam

Streaming on: Netflix

Honest and relevant, Vikruthi is a mirror of the times we live in, chronicling the downside of the obsession with social media. Translating to mischief, the film is sourced from a real incident and tells the story of a man who becomes the victim of a viral social media forward. What works for Vikruthi is the relatable way in which it tells its story and the non-judgmental stance it takes on to view its characters. Suraj Venjarammoodu and Soubin Shahir carry the film that released in October last year, winning us over with a mix of humour and heart.

Language: Kannada

Streaming on: Amazon Prime Video

A simple love story simply told is what makes Dia stand out at a time when audiences are being fed convoluted storylines in seemingly woke films which are anything but. This February film focuses on a love triangle and is a refreshing romance told from the point of view of the woman. An engaging blend of feel-good romance and the hopelessness that love sometimes brings in its wake, Dia powered by its emotional core and strong performances is worth a watch.

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Looking for options other than Holly, Bolly and Tolly to stream this lockdown? - Telegraph India