How Do We Terraform Mars? – Universe Today

As part of our continuing Definitive Guide To Terraforming series, Universe Today is happy to present our guide to terraforming Mars. At present, there are several plans to put astronauts and ever settlers on the Red Planet. But if we really want to live there someday, were going to need to do a complete planetary renovation. What will it take?

Despite having a very cold and very dry climate not to mention little atmosphere to speak of Earth and Mars have a lot in common. These include similarities in size, inclination, structure, composition, and even the presence of water on their surfaces. Because of this, Mars is considered a prime candidate for human settlement; a prospect that includes transforming the environment to be suitable to human needs (aka. terraforming).

That being said, there are also a lot of key differences that would make living on Mars, a growing preoccupation among many humans (looking at you, Elon Musk and Bas Lansdorp!), a significant challenge. If we were to live on the planet, we would have to depend rather heavily on our technology. And if we were going to alter the planet through ecological engineering, it would take a lot of time, effort, and megatons of resources!

The challenges of living on Mars are quite numerous. For starters, there is the extremely thin and unbreathable atmosphere. Whereas Earths atmosphere is composed of 78% nitrogen, 21% oxygen, and trace amounts of other gases, Mars atmosphere is made up of 96% carbon dioxide, 1.93% argon and 1.89% nitrogen, along with trace amounts of oxygen and water.

Mars atmospheric pressure also ranges from 0.4 0.87 kPa, which is the equivalent of about 1% of Earths at sea level. The thin atmosphere and greater distance from the Sun also contributes to Mars cold environment, where surface temperatures average 210 K (-63 C/-81.4 F). Add to this the fact that Mars lacks a magnetosphere, and you can see why the surface is exposed to significantly more radiation than Earths.

On the Martian surface, the average dose of radiation is about 0.67 millisieverts (mSv) per day, which is about a fifth of what people are exposed to here on Earth in the course of a year. Hence, if humans wanted to live on Mars without the need for radiation shielding, pressurized domes, bottled oxygen, and protective suits, some serious changes would need to be made. Basically, we would have to warm the planet, thicken the atmosphere, and alter the composition of said atmosphere.

In 1951, Arthur C. Clarke wrote the first novel in which the terraforming of Mars was presented in fiction. Titled The Sands of Mars, the story involves Martian settlers heating up the planet by converting Mars moon Phobos into a second sun, and growing plants that break down the Martians sands in order to release oxygen.

In 1984, James Lovelock and Michael Allaby wrote what is considered by many to be one of the most influential books on terraforming. Titled The Greening of Mars, the novel explores the formation and evolution of planets, the origin of life, and Earths biosphere. The terraforming models presented in the book actually foreshadowed future debates regarding the goals of terraforming.

In 1992, author Frederik Pohl released Mining The Oort, a science fiction story where Mars is being terraformed using comets diverted from the Oort Cloud. Throughout the 1990s, Kim Stanley Robinson released his famous Mars Trilogy Red Mars, Green Mars, Blue Mars which centers on the transformation of Mars over the course of many generations into a thriving human civilization.

In 2011, Yu Sasuga and Kenichi Tachibana produced the manga series Terra Formars, a series that takes place in the 21st century where scientists are attempting to slowly warm Mars. And in 2012, Kim Stanley Robinson released 2312, a story that takes place in a Solar System where multiple planets have been terraformed which includes Mars (which has oceans).

Over the past few decades, several proposals have been made for how Mars could be altered to suit human colonists. In 1964, Dandridge M. Cole released Islands in Space: The Challenge of the Planetoids, the Pioneering Work, in which he advocated triggering a greenhouse effect on Mars. This consisted of importing ammonia ices from the outer Solar System and then impacting them on the surface.

Since ammonia (NH) is a powerful greenhouse gas, its introduction into the Martian atmosphere would have the effect of thickening the atmosphere and raising global temperatures. As ammonia is mostly nitrogen by weight, it could also provide the necessary buffer gas which, when combined with oxygen gas, would create a breathable atmosphere for humans.

Another method has to do with albedo reduction, where the surface of Mars would be coated with dark materials in order to increase the amount of sunlight it absorbs. This could be anything from dust from Phobos and Deimos (two of the darkest bodies in the Solar System) to extremophile lichens and plants that are dark in color. One of the greatest proponents for this was famed author and scientist, Carl Sagan.

In 1973, Sagan published an article in the journal Icarus titled Planetary Engineering on Mars, where he proposed two scenarios for darkening the surface of Mars. These included transporting low albedo material and/or planting dark plants on the polar ice caps to ensure they absorbed more heat, melted, and converted the planet to more Earth-like conditions.

In 1976, NASA officially addressed the issue of planetary engineering in a study titled On the Habitability of Mars: An Approach to Planetary Ecosynthesis. The study concluded that photosynthetic organisms, the melting of the polar ice caps, and the introduction of greenhouse gases could all be used to create a warmer, oxygen and ozone-rich atmosphere.

In 1982, Planetologist Christopher McKay wrote Terraforming Mars, a paper for the Journal of the British Interplanetary Society. In it, McKay discussed the prospects of a self-regulating Martian biosphere, which included both the required methods for doing so and ethics of it. This was the first time that the word terraforming was used in the title of a published article, and would henceforth become the preferred term.

This was followed in 1984 by James Lovelock and Michael Allabys book, The Greening of Mars. In it, Lovelock and Allaby described how Mars could be warmed by importing chlorofluorocarbons (CFCs) to trigger global warming.

In 1993, Mars Society founder Dr. Robert M. Zubrin and Christopher P. McKay of the NASA Ames Research Center co-wrote Technological Requirements for Terraforming Mars. In it, they proposed using orbital mirrors to warm the Martian surface directly. Positioned near the poles, these mirrors would be able to sublimate theCO2 ice sheet and contribute to global warming.

In the same paper, they argued the possibility of using asteroids harvested from the Solar System, which would be redirected to impact the surface, kicking up dust and warming the atmosphere. In both scenarios, they advocate for the use of nuclear-electrical or nuclear-thermal rockets to haul all the necessary materials/asteroids into orbit.

The use of fluorine compounds super-greenhouse gases that produce a greenhouse effect thousands of times stronger than CO has also been recommended as a long term climate stabilizer. In 2001, a team of scientists from the Division of Geological and Planetary Sciences at Caltech made these recommendations in the Keeping Mars warm with new super greenhouse gases.

Where this study indicated that the initial payloads of fluorine would have to come from Earth (and be replenished regularly), it claimed that fluorine-containing minerals could also be mined on Mars. This is based on the assumption that such minerals are just as common on Mars (being a terrestrial planet) which would allow for a self-sustaining process once colonies were established.

Importing methane and other hydrocarbons from the outer Solar System which are plentiful on Saturns moon Titan has also been suggested. There is also the possibility of in-situ resource utilization (ISRU), thanks to the Curiosity rovers discovery of a tenfold spike of methane that pointed to a subterranean source. If these sources could be mined, methane might not even need to be imported.

More recent proposals include the creation of sealed biodomes that would employ colonies of oxygen-producing cyanobacteria and algae on Martian soil. In 2014, the NASA Institute for Advanced Concepts (NAIC) program and Techshot Inc. began work on this concept, which was named the Mars Ecopoiesis Test Bed. In the future, the project intends to send small canisters of extremophile photosynthetic algae and cyanobacteria aboard a rover mission to test the process in a Martian environment.

If this proves successful, NASA and Techshot intend to build several large biodomes to produce and harvest oxygen for future human missions to Mars which would cut costs and extend missions by reducing the amount of oxygen that has to be transported. While these plans do not constitute ecological or planetary engineering, Eugene Boland (chief scientist of Techshot Inc.) has stated that it is a step in that direction:

Ecopoiesis is the concept of initiating life in a new place; more precisely, the creation of an ecosystem capable of supporting life. It is the concept of initiating terraforming using physical, chemical and biological means including the introduction of ecosystem-building pioneer organisms This will be the first major leap from laboratory studies into the implementation of experimental (as opposed to analytical) planetary in situ research of greatest interest to planetary biology, ecopoiesis and terraforming.

Beyond the prospect for adventure and the idea of humanity once again embarking on an era of bold space exploration, there are several reasons why terraforming Mars is being proposed. For starters, there is concern that humanitys impact on planet Earth is unsustainable, and that we will need to expand and create a backup location if we intend to survive in the long run.

This school of though cites things like the Earths growing population which is expected to reach 9.6 billion by mid-century as well as the fact that by 2050, roughly two-thirds of the worlds population is expected to live in major cities. On top of that, there is the prospect of severe Climate Change, which according to a series of scenarios computed by NASA could result in life becoming untenable on certain parts of the planet by 2100.

Other reasons emphasize how Mars lies within our Suns Goldilocks Zone (aka. habitable zone), and was once a habitable planet. Over the past few decades, surface missions like NASAs Mars Science Laboratory (MSL) and its Curiosity rover have uncovered a wealth of evidence that points to flowing water existing on Mars in the deep past (as well as the existence of organic molecules).

In addition, NASAs Mars Atmosphere and Volatile EvolutioN Mission (MAVEN) (and other orbiters) have provided extensive information on Mars past atmosphere. What they have concluded is that roughly 4 billion years ago, Mars had abundant surface water and a thicker atmosphere. However, due to the loss of Mars magnetosphere which may have been caused by a large impact or rapid cooling of the planets interior the atmosphere was slowly stripped away.

Ergo, if Mars was once habitable and Earth-like, it is possible that it could be again one day. And if indeed humanity is looking for a new world to settle on, it only makes sense that it be on one that has as much in common with Earth as possible. In addition, it has also been argued that our experience with altering the climate of our own planet could be put to good use on Mars.

For centuries, our reliance on industrial machinery, coal and fossil fuels has had a measurable effect Earths environment. And whereas this has been an unintended consequence of modernization and development here on Earth; on Mars, the burning of fossil fuels and the regular release of pollution into the air would have a positive effect.

Other reasons include expanding our resources base and becoming a post-scarcity society. A colony on Mars could allow for mining operations on the Red Planet, where both minerals and water ice are abundant and could be harvested. A base on Mars could also act as a gateway to the Asteroid Belt, which would provide us with access to enough minerals to last us indefinitely.

Without a doubt, the prospect of terraforming Mars comes with its share of problems, all of which are particularly daunting. For starters, there is the sheer amount of resources it would take to convert Mars environment into something sustainable for humans. Second, there is the concern that any measure undertaken could have unintended consequences. And third, there is the amount of time it would take.

For example, when it comes to concepts that call for the introduction of greenhouse gases to trigger warming, the quantities required are quite staggering. The 2001 Caltech study, which called for the introduction of fluorine compounds, indicated that sublimating the south polar CO glaciers would require the introduction of approximately 39 million metric tons of CFCs into Mars atmosphere which is three times the amounts produced on Earth between 1972 and 1992.

Photolysis would also begin to break down the CFCs the moment they were introduced, which would necessitate the addition of 170 kilotons every year to replenish the losses. And last, the introduction of CFCs would also destroy any ozone that was produced, which would undermine efforts to shield to surface from radiation.

Also, the 1976 NASA feasibility study indicated that while terraforming Mars would be possible using terrestrial organisms, it also recognized that the time-frames called for would be considerable. As it states in the study:

No fundamental, insuperable limitation of the ability of Mars to support a terrestrial ecology is identified. The lack of an oxygen-containing atmosphere would prevent the unaided habitation of Mars by man. The present strong ultraviolet surface irradiation is an additional major barrier. The creation of an adequate oxygen and ozone-containing atmosphere on Mars may be feasible through the use of photosynthetic organisms. The time needed to generate such an atmosphere, however, might be several millions of years.

The study goes on to state that this could be drastically reduced by creating extremophile organisms specifically adapted for the harsh Martian environment, creating a greenhouse effect and melting the polar ice caps. However, the amount of time it would take to transform Mars would still likely be on the order of centuries or millennia.

And of course, there is the problem of infrastructure. Harvesting resources from other planets or moons in the Solar System would require a large fleet of space haulers, and they would need to be equipped with advanced drive systems to make the trip in a reasonable amount of time. Currently, no such drive systems exist, and conventional methods ranging from ion engines to chemical propellants are neither fast or economical enough.

To illustrate, NASAs New Horizons mission took more than 11 years to get make its historic rendezvous with Pluto in the Kuiper Belt, using conventional rockets and the gravity-assist method. Meanwhile, the Dawn mission, which relied relied on ionic propulsion, took almost four years to reach Vesta in the Asteroid Belt. Neither method is practical for making repeated trips to the Kuiper Belt and hauling back icy comets and asteroids, and humanity has nowhere near the number of ships we would need to do this.

On the other hand, going the in-situ route which would involve factories or mining operations on the surface to release CO, methane or CFC-containing minerals into the air would require several heavy-payload rockets to get all the machinery to the Red Planet. The cost of this would dwarf all space programs to date. And once they were assembled on the surface (either by robotic or human workers), these operations would have to be run continuously for centuries.

There is also several questions about the ethics of terraforming. Basically, altering other planets in order to make them more suitable to human needs raises the natural question of what would happen to any lifeforms already living there. If in fact Mars does have indigenous microbial life (or more complex lifeforms), which many scientists suspect, then altering the ecology could impact or even wipe out these lifeforms. In short, future colonists and terrestrial engineers would effectively be committing genocide.

Given all of these arguments, one has to wonder what the benefits of terraforming Mars would be. While the idea of utilizing the resources of the Solar System makes sense in the long-run, the short-term gains are far less tangible. Basically, harvested resources from other worlds is not economically viable when you can extract them here at home for much less. And given the danger, who would want to go?

But as ventures like MarsOne have shown, there are plenty of human beings who are willing to make a one-way trip to Mars and act as Earths first-wave of intrepid explorers. In addition, NASA and other space agencies have been very vocal about their desire to explore the Red Planet, which includes manned missions by the 2030s. And as various polls show, public support is behind these endeavors, even if it means drastically increased budgets.

So why do it? Why terraform Mars for human use? Because it is there? Sure. But more importantly, because we might need to. And the drive and the desire to colonize it is also there. And despite the difficulty inherent in each, there is no shortage of proposed methods that have been weighed and determined feasible.In the end, all thats needed is a lot of time, a lot of commitment, a lot of resources, and a lot of care to make sure we are not irrevocably harming life forms that are already there.

But of course, should our worst predictions come to pass, we may find in the end that we have little choice but to make a home somewhere else in the Solar System. As this century progresses, it may very well be Mars or bust!

We have written many interesting articles about terraforming here at Universe Today. Heres The Definitive Guide To Terraforming, Could We Terraform the Moon?, Should We Terraform Mars?, How Do We Terraform Venus?, and Student Team Wants to Terraform Mars Using Cyanobacteria.

Weve also got articles that explore the more radical side of terraforming, like Could We Terraform Jupiter?, Could We Terraform The Sun?, and Could We Terraform A Black Hole?

Astronomy Cast also has good episodes on the subject, like Episode 96: Humans to Mar, Part 3 Terraforming Mars

For more information, check out Terraforming Mars at NASA Quest! and NASAs Journey to Mars.

And if you like the video, come check out our Patreon page and find out how you can get these videos early while helping us bring you more great content!

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How Do We Terraform Mars? - Universe Today

What is Terraforming? – Terraforming Mars – sites.google.com

Terraforming

The term "terraforming" was originally coined by author Jack Williamson in the early 1940's. Literally, the term means "Earth forming" or "Earth shaping". Terraforming refers to engineering any celestial body (planet, moon, asteroid, etc.) to resemble Earth, generally through the manipulation of temperature, atmosphere, topography, and ecology. "Planetary engineering" is another term that is frequently associated with, and substituted for, terraforming. However, technically speaking, planetary engineering is seen more broadly as the application of technology in altering the properties of a planet, while terraforming is a more specified process of planetary engineering which focuses on altering extraterrestrial terrain to be more like that on Earth.

With current technology and future technological promise, altering small portions of a planet's environment and sustaining them in a desired condition is plausible through the implementation of machinery, technology, and other commodities supplied from Earth. However, the ideal goal of terraforming would be to create an aerobic environment that is capable of sustaining plant and animal life naturally- removing, or at least diminishing, the need for the input of Earthly materials and constant monitoring. The first step to attain this end product involves the development of a stable, enduring ecosystem, a process known as ecopoiesis. Robert Haynes, who coined the term, states, "Ecopoiesis is now used in literature to describe the implantation of a pioneering, and hence microbial, ecosystem on a planet, either as an end itself, or as an initial stage in a more lengthy process of terraforming. Ecopoiesis is a more modest aim, with less of the speculative extravagance associated with terraforming." Ecopoiesis alone would not be sufficient in creating an environment in which humans or animals could survive outdoors however, which is why terraforming must be used in conjunction with the process of ecopoiesis in order to create a sustainable, Earth-like environment. In respect to the planet Mars- the focus of this website- there are five explicit steps that must be carried out before the processes of ecopoiesis, and consequently, terraforming can be attempted/completed. The steps are as follows:

There are a variety of proposed methods to attain these five necessary alterations. These are defined, discussed, compared, and contrasted in depth in the "Real World Application" and "Literary Portrayal" tabs.

Terraforming goes beyond the physical act of altering a planet. It allows us a certain amount of inquisition into the human psyche as well. Why do we have the desire to terraform?Ever since the beginning of time, humans have had an instinctive drive to conquer the unknown, and refashion it to fit our modes of thinking. We see this throughout all of history- the expansion of countries through the conquest and colonization of foreign populace is not a new concept to the human race. With the emergence of planetary colonization in the science fiction genre came a new form of an almost intergalactic imperialism. Humans could now impose our will across the universe. Narrowing the focus of this idea from populations, countries, and even planets, to environments, and we can see how terraforming embodies the human drive for conquest, expansion, and assimilation.

The process of terraforming is highly controversial andentails a vast number of political and ethical questions. Ethically, the question of if we even have the right to impose our will on another planet is central when thinking about terraforming. Furthermore, are we justified in attempting to make another planet more like our own, or should we instead take an approach that embraces the planet's own ecology/ natural environment? And if we plan on using terraforming to sustain human life on Mars, can we free ourselves from the harmful tendencies toward ecological destruction we have imposed on our own planet? Or will the terraforming of Mars ultimately lead to its degradation through human destruction as well?

Politically, if terraforming leads to planetary colonization on Mars, what form of government should exist? Who has the right to live on the planet? Should it eventually become independent of Earth?Furthermore, the cost of terraforming would be immense, and the payoff, if any, could take thousands of years. Who would fund this daring process? And is it worth the economic strain if there will be no short term payoff within our lifetime?

There's also the debate on resources and technology. While we currently don't have the advanced technologies imagined by some scientists for the completion of a terraforming project, some believe we should begin the project now and trust that these technologies will emerge with time. There are others, however, who believe we should wait until we definitely have the necessary technologies before embarking on this gargantuan undertaking.We will take a look at some of the opposing viewpoints of the moral, political, and technical debates on terraforming, in both literature and the real world, in the "Real World Application" and"Literary Portrayal"tabs.

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What is Terraforming? - Terraforming Mars - sites.google.com

How Terraforming Mars Will Work | HowStuffWorks

We have been going to space for decades now, but until the year 2000, those stays in orbit were always temporary. However, when three astronauts moved into the International Space Station (ISS) for a four-month stay, it marked the beginning of a decade and a half of a permanent human presence in space. The arrival of these three astronauts at the ISS on Nov. 2, 2000, sparked one NASA official to remark, "We're going into space forever with people first circling this globe, and then we're going to Mars...."

Why would we ever want to go to Mars? As pictures beamed back from planetary probes and rovers since 1964 have shown, Mars is a desolate, lifeless planet with seemingly little to offer humans. It has a very thin atmosphere and no signs of existing life -- but Mars does hold some promise for the continuation of the human race. There are more than six billion people on Earth, and that number continues to grow unabated. This overcrowding, or the possibility of planetary disaster, will force us to eventually consider new homes in our solar system, and Mars may have more to offer us than the photos of its barren landscape now show.

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How Terraforming Mars Will Work | HowStuffWorks

Sea – Wikipedia

Large body of salt water

The sea in a general sense refers to the ocean or world ocean, the body of salty water that covers approximately 71% of the Earth's surface. Used in a particular sense the word sea refers to particular seas either as second-order sections of the ocean, such as the Mediterranean Sea, or as certain large, entirely landlocked, saltwater lakes, such as the Caspian Sea. The sea moderates Earth's climate and has important roles in the water, carbon, and nitrogen cycles. Humans harnessing and studying the sea have been recorded since ancient times, and evidenced well into prehistory, while its modern scientific study is called oceanography. The most abundant solid dissolved in seawater is sodium chloride. The water also contains salts of magnesium, calcium, potassium, and mercury, amongst many other elements, some in minute concentrations. Salinity varies widely, being lower near the surface and the mouths of large rivers and higher in the depths of the ocean; however, the relative proportions of dissolved salts vary little across the oceans.

Winds blowing over the surface of the sea produce waves, which break when they enter the shallow water near land. Winds also create surface currents through friction, setting up slow but stable circulations of water throughout the oceans. The directions of the circulation are governed by several factors including the shapes of the continents and Earth's rotation (through the Coriolis effect). Deep-sea currents, known as the global conveyor belt, carry cold water from near the poles to every ocean. Tides, the generally twice-daily rise and fall of sea levels, are caused by Earth's rotation and the gravitational effects of the Moon and, to a lesser extent, of the Sun. Tides may have a very high range in bays or estuaries. Submarine earthquakes arising from tectonic plate movements under the oceans can lead to destructive tsunamis, as can volcanoes, huge landslides, or the impact of large meteorites.

A wide variety of organisms, including bacteria, protists, algae, plants, fungi, and animals, lives in the sea, which offers a wide range of marine habitats and ecosystems, ranging vertically from the sunlit surface and shoreline to the great depths and pressures of the cold, dark abyssal zone, and in latitude from the cold waters under polar ice caps to the warm waters of coral reefs in tropical regions. Many of the major groups of organisms evolved in the sea and life may have started there.

The sea provides substantial supplies of food for humans, mainly fish, but also shellfish, mammals and seaweed, whether caught by fishermen or farmed underwater. Other human uses of the sea include trade, travel, mineral extraction, power generation, warfare, and leisure activities such as swimming, sailing, and scuba diving. Many of these activities create marine pollution. The sea has been an integral element for humans throughout history and culture.

The sea is the interconnected system of all the Earth's oceanic waters, including the Atlantic, Pacific, Indian, Southern and Arctic Oceans.[1] However, the word "sea" can also be used for many specific, much smaller bodies of seawater, such as the North Sea or the Red Sea. There is no sharp distinction between seas and oceans, though generally seas are smaller, and are often partly (as marginal seas or particularly as the Mediterranean sea) or wholly (as inland seas) enclosed by land.[2] However, an exception to this is the Sargasso Sea which has no coastline and lies within a circular current, the North Atlantic Gyre.[3]:90 Seas are generally larger than lakes and contain salt water, but the Sea of Galilee is a freshwater lake.[4][a] The United Nations Convention on the Law of the Sea states that all of the ocean is "sea".[8][9][b]

Earth is the only known planet with seas of liquid water on its surface,[3]:22 although Mars possesses ice caps and similar planets in other solar systems may have oceans.[11] Earth's 1,335,000,000 cubic kilometers (320,000,000cumi) of sea contain about 97.2 percent of its known water[12][c] and cover approximately 71 percent of its surface.[3]:7[17] Another 2.15% of Earth's water is frozen, found in the sea ice covering the Arctic Ocean, the ice cap covering Antarctica and its adjacent seas, and various glaciers and surface deposits around the world. The remainder (about 0.65% of the whole) form underground reservoirs or various stages of the water cycle, containing the freshwater encountered and used by most terrestrial life: vapor in the air, the clouds it slowly forms, the rain falling from them, and the lakes and rivers spontaneously formed as its waters flow again and again to the sea.[12]

The scientific study of water and Earth's water cycle is hydrology; hydrodynamics studies the physics of water in motion. The more recent study of the sea in particular is oceanography. This began as the study of the shape of the ocean's currents[18] but has since expanded into a large and multidisciplinary field:[19] it examines the properties of seawater; studies waves, tides, and currents; charts coastlines and maps the seabeds; and studies marine life.[20] The subfield dealing with the sea's motion, its forces, and the forces acting upon it is known as physical oceanography.[21] Marine biology (biological oceanography) studies the plants, animals, and other organisms inhabiting marine ecosystems. Both are informed by chemical oceanography, which studies the behavior of elements and molecules within the oceans: particularly, at the moment, the ocean's role in the carbon cycle and carbon dioxide's role in the increasing acidification of seawater. Marine and maritime geography charts the shape and shaping of the sea, while marine geology (geological oceanography) has provided evidence of continental drift and the composition and structure of the Earth, clarified the process of sedimentation, and assisted the study of volcanism and earthquakes.[19]

A characteristic of seawater is that it is salty. Salinity is usually measured in parts per thousand ( or per mil), and the open ocean has about 35 grams (1.2oz) solids per litre, a salinity of 35. The Mediterranean Sea is slightly higher at 38,[22] while the salinity of the northern Red Sea can reach 41.[23] In contrast, some landlocked hypersaline lakes have a much higher salinity, for example the Dead Sea has 300 grams (11oz) dissolved solids per litre (300).

While the constituents of table salt (sodium and chloride) make up about 85 percent of the solids in solution, there are also other metal ions such as magnesium and calcium, and negative ions including sulphate, carbonate, and bromide. Despite variations in the levels of salinity in different seas, the relative composition of the dissolved salts is stable throughout the world's oceans.[24][25] Seawater is too saline for humans to drink safely, as the kidneys cannot excrete urine as salty as seawater.[26]

Although the amount of salt in the ocean remains relatively constant within the scale of millions of years, various factors affect the salinity of a body of water.[27] Evaporation and by-product of ice formation (known as "brine rejection") increase salinity, whereas precipitation, sea ice melt, and runoff from land reduce it.[27] The Baltic Sea, for example, has many rivers flowing into it, and thus the sea could be considered as brackish.[28] Meanwhile, the Red Sea is very salty due to its high evaporation rate.[29]

Sea temperature depends on the amount of solar radiation falling on its surface. In the tropics, with the sun nearly overhead, the temperature of the surface layers can rise to over 30C (86F) while near the poles the temperature in equilibrium with the sea ice is about 2C (28F). There is a continuous circulation of water in the oceans. Warm surface currents cool as they move away from the tropics, and the water becomes denser and sinks. The cold water moves back towards the equator as a deep sea current, driven by changes in the temperature and density of the water, before eventually welling up again towards the surface. Deep seawater has a temperature between 2C (28F) and 5C (41F) in all parts of the globe.[30]

Seawater with a typical salinity of 35 has a freezing point of about 1.8C (28.8F).[citation needed] When its temperature becomes low enough, ice crystals form on the surface. These break into small pieces and coalesce into flat discs that form a thick suspension known as frazil. In calm conditions this freezes into a thin flat sheet known as nilas, which thickens as new ice forms on its underside. In more turbulent seas, frazil crystals join into flat discs known as pancakes. These slide under each other and coalesce to form floes. In the process of freezing, salt water and air are trapped between the ice crystals. Nilas may have a salinity of 1215, but by the time the sea ice is one year old, this falls to 46.[31]

The amount of oxygen found in seawater depends primarily on the plants growing in it. These are mainly algae, including phytoplankton, with some vascular plants such as seagrasses. In daylight the photosynthetic activity of these plants produces oxygen, which dissolves in the seawater and is used by marine animals. At night, photosynthesis stops, and the amount of dissolved oxygen declines. In the deep sea, where insufficient light penetrates for plants to grow, there is very little dissolved oxygen. In its absence, organic material is broken down by anaerobic bacteria producing hydrogen sulphide.[32]

Climate change is likely to reduce levels of oxygen in surface waters, since the solubility of oxygen in water falls at higher temperatures.[33] Ocean deoxygenation is projected to increase hypoxia by 10%, and triple suboxic waters (oxygen concentrations 98% less than the mean surface concentrations), for each 1C of upper ocean warming.[34]

The amount of light that penetrates the sea depends on the angle of the sun, the weather conditions and the turbidity of the water. Much light gets reflected at the surface, and red light gets absorbed in the top few metres. Yellow and green light reach greater depths, and blue and violet light may penetrate as deep as 1,000 metres (3,300ft). There is insufficient light for photosynthesis and plant growth beyond a depth of about 200 metres (660ft).[35]

Over most of geologic time, the sea level has been higher than it is today.[3]:74 The main factor affecting sea level over time is the result of changes in the oceanic crust, with a downward trend expected to continue in the very long term.[36] At the last glacial maximum, some 20,000 years ago, the sea level was about 125 metres (410ft) lower than in present times (2012).[37]

For at least the last 100 years, sea level has been rising at an average rate of about 1.8 millimetres (0.071in) per year.[38] Most of this rise can be attributed to an increase in the temperature of the sea due to climate change, and the resulting slight thermal expansion of the upper 500 metres (1,600ft) of water. Additional contributions, as much as one quarter of the total, come from water sources on land, such as melting snow and glaciers and extraction of groundwater for irrigation and other agricultural and human needs.[39]

Wind blowing over the surface of a body of water forms waves that are perpendicular to the direction of the wind. The friction between air and water caused by a gentle breeze on a pond causes ripples to form. A strong blow over the ocean causes larger waves as the moving air pushes against the raised ridges of water. The waves reach their maximum height when the rate at which they are travelling nearly matches the speed of the wind. In open water, when the wind blows continuously as happens in the Southern Hemisphere in the Roaring Forties, long, organised masses of water called swell roll across the ocean.[3]:8384[40][41][d] If the wind dies down, the wave formation is reduced, but already-formed waves continue to travel in their original direction until they meet land. The size of the waves depends on the fetch, the distance that the wind has blown over the water and the strength and duration of that wind. When waves meet others coming from different directions, interference between the two can produce broken, irregular seas.[40] Constructive interference can cause individual (unexpected) rogue waves much higher than normal.[42] Most waves are less than 3m (10ft) high[42] and it is not unusual for strong storms to double or triple that height;[43] offshore construction such as wind farms and oil platforms use metocean statistics from measurements in computing the wave forces (due to for instance the hundred-year wave) they are designed against.[44] Rogue waves, however, have been documented at heights above 25 meters (82ft).[45][46]

The top of a wave is known as the crest, the lowest point between waves is the trough and the distance between the crests is the wavelength. The wave is pushed across the surface of the sea by the wind, but this represents a transfer of energy and not a horizontal movement of water. As waves approach land and move into shallow water, they change their behavior. If approaching at an angle, waves may bend (refraction) or wrap rocks and headlands (diffraction). When the wave reaches a point where its deepest oscillations of the water contact the seabed, they begin to slow down. This pulls the crests closer together and increases the waves' height, which is called wave shoaling. When the ratio of the wave's height to the water depth increases above a certain limit, it "breaks", toppling over in a mass of foaming water.[42] This rushes in a sheet up the beach before retreating into the sea under the influence of gravity.[40]

A tsunami is an unusual form of wave caused by an infrequent powerful event such as an underwater earthquake or landslide, a meteorite impact, a volcanic eruption or a collapse of land into the sea. These events can temporarily lift or lower the surface of the sea in the affected area, usually by a few feet. The potential energy of the displaced seawater is turned into kinetic energy, creating a shallow wave, a tsunami, radiating outwards at a velocity proportional to the square root of the depth of the water and which therefore travels much faster in the open ocean than on a continental shelf.[47] In the deep open sea, tsunamis have wavelengths of around 80 to 300 miles (130 to 480km), travel at speeds of over 600 miles per hour (970km/hr)[48] and usually have a height of less than three feet, so they often pass unnoticed at this stage.[49] In contrast, ocean surface waves caused by winds have wavelengths of a few hundred feet, travel at up to 65 miles per hour (105km/h) and are up to 45 feet (14 metres) high.[49]

As a tsunami moves into shallower water its speed decreases, its wavelength shortens and its amplitude increases enormously,[49] behaving in the same way as a wind-generated wave in shallow water, but on a vastly greater scale. Either the trough or the crest of a tsunami can arrive at the coast first.[47] In the former case, the sea draws back and leaves subtidal areas close to the shore exposed which provides a useful warning for people on land.[50] When the crest arrives, it does not usually break but rushes inland, flooding all in its path. Much of the destruction may be caused by the flood water draining back into the sea after the tsunami has struck, dragging debris and people with it. Often several tsunami are caused by a single geological event and arrive at intervals of between eight minutes and two hours. The first wave to arrive on shore may not be the biggest or most destructive.[47]

Wind blowing over the surface of the sea causes friction at the interface between air and sea. Not only does this cause waves to form but it also makes the surface seawater move in the same direction as the wind. Although winds are variable, in any one place they predominantly blow from a single direction and thus a surface current can be formed. Westerly winds are most frequent in the mid-latitudes while easterlies dominate the tropics.[51] When water moves in this way, other water flows in to fill the gap and a circular movement of surface currents known as a gyre is formed. There are five main gyres in the world's oceans: two in the Pacific, two in the Atlantic and one in the Indian Ocean. Other smaller gyres are found in lesser seas and a single gyre flows around Antarctica. These gyres have followed the same routes for millennia, guided by the topography of the land, the wind direction and the Coriolis effect. The surface currents flow in a clockwise direction in the Northern Hemisphere and anticlockwise in the Southern Hemisphere. The water moving away from the equator is warm, and that flowing in the reverse direction has lost most of its heat. These currents tend to moderate the Earth's climate, cooling the equatorial region and warming regions at higher latitudes.[52] Global climate and weather forecasts are powerfully affected by the world ocean, so global climate modelling makes use of ocean circulation models as well as models of other major components such as the atmosphere, land surfaces, aerosols and sea ice.[53] Ocean models make use of a branch of physics, geophysical fluid dynamics, that describes the large-scale flow of fluids such as seawater.[54]

Surface currents only affect the top few hundred metres of the sea, but there are also large-scale flows in the ocean depths caused by the movement of deep water masses. A main deep ocean current flows through all the world's oceans and is known as the thermohaline circulation or global conveyor belt. This movement is slow and is driven by differences in density of the water caused by variations in salinity and temperature.[55] At high latitudes the water is chilled by the low atmospheric temperature and becomes saltier as sea ice crystallizes out. Both these factors make it denser, and the water sinks. From the deep sea near Greenland, such water flows southwards between the continental landmasses on either side of the Atlantic. When it reaches the Antarctic, it is joined by further masses of cold, sinking water and flows eastwards. It then splits into two streams that move northwards into the Indian and Pacific Oceans. Here it is gradually warmed, becomes less dense, rises towards the surface and loops back on itself. It takes a thousand years for this circulation pattern to be completed.[52]

Besides gyres, there are temporary surface currents that occur under specific conditions. When waves meet a shore at an angle, a longshore current is created as water is pushed along parallel to the coastline. The water swirls up onto the beach at right angles to the approaching waves but drains away straight down the slope under the effect of gravity. The larger the breaking waves, the longer the beach and the more oblique the wave approach, the stronger is the longshore current.[56] These currents can shift great volumes of sand or pebbles, create spits and make beaches disappear and water channels silt up.[52] A rip current can occur when water piles up near the shore from advancing waves and is funnelled out to sea through a channel in the seabed. It may occur at a gap in a sandbar or near a man-made structure such as a groyne. These strong currents can have a velocity of 3ft (0.9m) per second, can form at different places at different stages of the tide and can carry away unwary bathers.[57] Temporary upwelling currents occur when the wind pushes water away from the land and deeper water rises to replace it. This cold water is often rich in nutrients and creates blooms of phytoplankton and a great increase in the productivity of the sea.[52]

Tides are the regular rise and fall in water level experienced by seas and oceans in response to the gravitational influences of the Moon and the Sun, and the effects of the Earth's rotation. During each tidal cycle, at any given place the water rises to a maximum height known as "high tide" before ebbing away again to the minimum "low tide" level. As the water recedes, it uncovers more and more of the foreshore, also known as the intertidal zone. The difference in height between the high tide and low tide is known as the tidal range or tidal amplitude.[58][59]

Most places experience two high tides each day, occurring at intervals of about 12 hours and 25 minutes. This is half the 24 hours and 50 minute period that it takes for the Earth to make a complete revolution and return the Moon to its previous position relative to an observer. The Moon's mass is some 27million times smaller than the Sun, but it is 400 times closer to the Earth.[60] Tidal force or tide-raising force decreases rapidly with distance, so the moon has more than twice as great an effect on tides as the Sun.[60] A bulge is formed in the ocean at the place where the Earth is closest to the Moon, because it is also where the effect of the Moon's gravity is stronger. On the opposite side of the Earth, the lunar force is at its weakest and this causes another bulge to form. As the Moon rotates around the Earth, so do these ocean bulges move around the Earth. The gravitational attraction of the Sun is also working on the seas, but its effect on tides is less powerful than that of the Moon, and when the Sun, Moon and Earth are all aligned (full moon and new moon), the combined effect results in the high "spring tides". In contrast, when the Sun is at 90 from the Moon as viewed from Earth, the combined gravitational effect on tides is less causing the lower "neap tides".[58]

A storm surge can occur when high winds pile water up against the coast in a shallow area and this, coupled with a low pressure system, can raise the surface of the sea at high tide dramatically.

The Earth is composed of a magnetic central core, a mostly liquid mantle and a hard rigid outer shell (or lithosphere), which is composed of the Earth's rocky crust and the deeper mostly solid outer layer of the mantle. On land the crust is known as the continental crust while under the sea it is known as the oceanic crust. The latter is composed of relatively dense basalt and is some five to ten kilometres (three to six miles) thick. The relatively thin lithosphere floats on the weaker and hotter mantle below and is fractured into a number of tectonic plates.[61] In mid-ocean, magma is constantly being thrust through the seabed between adjoining plates to form mid-oceanic ridges and here convection currents within the mantle tend to drive the two plates apart. Parallel to these ridges and nearer the coasts, one oceanic plate may slide beneath another oceanic plate in a process known as subduction. Deep trenches are formed here and the process is accompanied by friction as the plates grind together. The movement proceeds in jerks which cause earthquakes, heat is produced and magma is forced up creating underwater mountains, some of which may form chains of volcanic islands near to deep trenches. Near some of the boundaries between the land and sea, the slightly denser oceanic plates slide beneath the continental plates and more subduction trenches are formed. As they grate together, the continental plates are deformed and buckle causing mountain building and seismic activity.[62][63]

The Earth's deepest trench is the Mariana Trench which extends for about 2,500 kilometres (1,600mi) across the seabed. It is near the Mariana Islands, a volcanic archipelago in the West Pacific. Its deepest point is 10.994 kilometres (nearly 7 miles) below the surface of the sea.[64]

The zone where land meets sea is known as the coast and the part between the lowest spring tides and the upper limit reached by splashing waves is the shore. A beach is the accumulation of sand or shingle on the shore.[65] A headland is a point of land jutting out into the sea and a larger promontory is known as a cape. The indentation of a coastline, especially between two headlands, is a bay, a small bay with a narrow inlet is a cove and a large bay may be referred to as a gulf.[66] Coastlines are influenced by a number of factors including the strength of the waves arriving on the shore, the gradient of the land margin, the composition and hardness of the coastal rock, the inclination of the off-shore slope and the changes of the level of the land due to local uplift or submergence. Normally, waves roll towards the shore at the rate of six to eight per minute and these are known as constructive waves as they tend to move material up the beach and have little erosive effect. Storm waves arrive on shore in rapid succession and are known as destructive waves as the swash moves beach material seawards. Under their influence, the sand and shingle on the beach is ground together and abraded. Around high tide, the power of a storm wave impacting on the foot of a cliff has a shattering effect as air in cracks and crevices is compressed and then expands rapidly with release of pressure. At the same time, sand and pebbles have an erosive effect as they are thrown against the rocks. This tends to undercut the cliff, and normal weathering processes such as the action of frost follows, causing further destruction. Gradually, a wave-cut platform develops at the foot of the cliff and this has a protective effect, reducing further wave-erosion.[65]

Material worn from the margins of the land eventually ends up in the sea. Here it is subject to attrition as currents flowing parallel to the coast scour out channels and transport sand and pebbles away from their place of origin. Sediment carried to the sea by rivers settles on the seabed causing deltas to form in estuaries. All these materials move back and forth under the influence of waves, tides and currents.[65] Dredging removes material and deepens channels but may have unexpected effects elsewhere on the coastline. Governments make efforts to prevent flooding of the land by the building of breakwaters, seawalls, dykes and levees and other sea defences. For instance, the Thames Barrier is designed to protect London from a storm surge,[67] while the failure of the dykes and levees around New Orleans during Hurricane Katrina created a humanitarian crisis in the United States.

The sea plays a part in the water or hydrological cycle, in which water evaporates from the ocean, travels through the atmosphere as vapour, condenses, falls as rain or snow, thereby sustaining life on land, and largely returns to the sea.[68] Even in the Atacama Desert, where little rain ever falls, dense clouds of fog known as the camanchaca blow in from the sea and support plant life.[69]

In central Asia and other large land masses, there are endorheic basins which have no outlet to the sea, separated from the ocean by mountains or other natural geologic features that prevent the water draining away. The Caspian Sea is the largest one of these. Its main inflow is from the River Volga, there is no outflow and the evaporation of water makes it saline as dissolved minerals accumulate. The Aral Sea in Kazakhstan and Uzbekistan, and Pyramid Lake in the western United States are further examples of large, inland saline water-bodies without drainage. Some endorheic lakes are less salty, but all are sensitive to variations in the quality of the inflowing water.[70]

Oceans contain the greatest quantity of actively cycled carbon in the world and are second only to the lithosphere in the amount of carbon they store.[71] The oceans' surface layer holds large amounts of dissolved organic carbon that is exchanged rapidly with the atmosphere. The deep layer's concentration of dissolved inorganic carbon is about 15 percent higher than that of the surface layer[72] and it remains there for much longer periods of time.[73] Thermohaline circulation exchanges carbon between these two layers.[71]

Carbon enters the ocean as atmospheric carbon dioxide dissolves in the surface layers and is converted into carbonic acid, carbonate, and bicarbonate:[74]

It can also enter through rivers as dissolved organic carbon and is converted by photosynthetic organisms into organic carbon. This can either be exchanged throughout the food chain or precipitated into the deeper, more carbon rich layers as dead soft tissue or in shells and bones as calcium carbonate. It circulates in this layer for long periods of time before either being deposited as sediment or being returned to surface waters through thermohaline circulation.[73]

The oceans are home to a diverse collection of life forms that use it as a habitat. Since sunlight illuminates only the upper layers, the major part of the ocean exists in permanent darkness. As the different depth and temperature zones each provide habitat for a unique set of species, the marine environment as a whole encompasses an immense diversity of life.[75] Marine habitats range from surface water to the deepest oceanic trenches, including coral reefs, kelp forests, seagrass meadows, tidepools, muddy, sandy and rocky seabeds, and the open pelagic zone. The organisms living in the sea range from whales 30 metres (100ft) long to microscopic phytoplankton and zooplankton, fungi, and bacteria. Marine life plays an important part in the carbon cycle as photosynthetic organisms convert dissolved carbon dioxide into organic carbon and it is economically important to humans for providing fish for use as food.[76][77]:204229

Life may have originated in the sea and all the major groups of animals are represented there. Scientists differ as to precisely where in the sea life arose: the Miller-Urey experiments suggested a dilute chemical "soup" in open water, but more recent suggestions include volcanic hot springs, fine-grained clay sediments, or deep-sea "black smoker" vents, all of which would have provided protection from damaging ultraviolet radiation which was not blocked by the early Earth's atmosphere.[3]:138140

Marine habitats can be divided horizontally into coastal and open ocean habitats. Coastal habitats extend from the shoreline to the edge of the continental shelf. Most marine life is found in coastal habitats, even though the shelf area occupies only 7 percent of the total ocean area. Open ocean habitats are found in the deep ocean beyond the edge of the continental shelf. Alternatively, marine habitats can be divided vertically into pelagic (open water), demersal (just above the seabed) and benthic (sea bottom) habitats. A third division is by latitude: from polar seas with ice shelves, sea ice and icebergs, to temperate and tropical waters.[3]:150151

Coral reefs, the so-called "rainforests of the sea", occupy less than 0.1 percent of the world's ocean surface, yet their ecosystems include 25 percent of all marine species.[78] The best-known are tropical coral reefs such as Australia's Great Barrier Reef, but cold water reefs harbour a wide array of species including corals (only six of which contribute to reef formation).[3]:204207[79]

Marine primary producers plants and microscopic organisms in the plankton are widespread and very essential for the ecosystem. It has been estimated that half of the world's oxygen is produced by phytoplankton.[80][81] About 45 percent of the sea's primary production of living material is contributed by diatoms.[82] Much larger algae, commonly known as seaweeds, are important locally; Sargassum forms floating drifts, while kelp form seabed forests.[77]:246255 Flowering plants in the form of seagrasses grow in "meadows" in sandy shallows,[83] mangroves line the coast in tropical and subtropical regions[84] and salt-tolerant plants thrive in regularly inundated salt marshes.[85] All of these habitats are able to sequester large quantities of carbon and support a biodiverse range of larger and smaller animal life.[86]

Light is only able to penetrate the top 200 metres (660ft) so this is the only part of the sea where plants can grow.[35] The surface layers are often deficient in biologically active nitrogen compounds. The marine nitrogen cycle consists of complex microbial transformations which include the fixation of nitrogen, its assimilation, nitrification, anammox and denitrification.[87] Some of these processes take place in deep water so that where there is an upwelling of cold waters, and also near estuaries where land-sourced nutrients are present, plant growth is higher. This means that the most productive areas, rich in plankton and therefore also in fish, are mainly coastal.[3]:160163

There is a broader spectrum of higher animal taxa in the sea than on land, many marine species have yet to be discovered and the number known to science is expanding annually.[88] Some vertebrates such as seabirds, seals and sea turtles return to the land to breed but fish, cetaceans and sea snakes have a completely aquatic lifestyle and many invertebrate phyla are entirely marine. In fact, the oceans teem with life and provide many varying microhabitats.[88] One of these is the surface film which, even though tossed about by the movement of waves, provides a rich environment and is home to bacteria, fungi, microalgae, protozoa, fish eggs and various larvae.[89]

The pelagic zone contains macro- and microfauna and myriad zooplankton which drift with the currents. Most of the smallest organisms are the larvae of fish and marine invertebrates which liberate eggs in vast numbers because the chance of any one embryo surviving to maturity is so minute.[90] The zooplankton feed on phytoplankton and on each other and form a basic part of the complex food chain that extends through variously sized fish and other nektonic organisms to large squid, sharks, porpoises, dolphins and whales.[91] Some marine creatures make large migrations, either to other regions of the ocean on a seasonal basis or vertical migrations daily, often ascending to feed at night and descending to safety by day.[92] Ships can introduce or spread invasive species through the discharge of ballast water or the transport of organisms that have accumulated as part of the fouling community on the hulls of vessels.[93]

The demersal zone supports many animals that feed on benthic organisms or seek protection from predators and the seabed provides a range of habitats on or under the surface of the substrate which are used by creatures adapted to these conditions. The tidal zone with its periodic exposure to the dehydrating air is home to barnacles, molluscs and crustaceans. The neritic zone has many organisms that need light to flourish. Here, among algal encrusted rocks live sponges, echinoderms, polychaete worms, sea anemones and other invertebrates. Corals often contain photosynthetic symbionts and live in shallow waters where light penetrates. The extensive calcareous skeletons they extrude build up into coral reefs which are an important feature of the seabed. These provide a biodiverse habitat for reef dwelling organisms. There is less sea life on the floor of deeper seas but marine life also flourishes around seamounts that rise from the depths, where fish and other animals congregate to spawn and feed. Close to the seabed live demersal fish that feed largely on pelagic organisms or benthic invertebrates.[94] Exploration of the deep sea by submersibles revealed a new world of creatures living on the seabed that scientists had not previously known to exist. Some like the detrivores rely on organic material falling to the ocean floor. Others cluster round deep sea hydrothermal vents where mineral-rich flows of water emerge from the seabed, supporting communities whose primary producers are sulphide-oxidising chemoautotrophic bacteria, and whose consumers include specialised bivalves, sea anemones, barnacles, crabs, worms and fish, often found nowhere else.[3]:212 A dead whale sinking to the bottom of the ocean provides food for an assembly of organisms which similarly rely largely on the actions of sulphur-reducing bacteria. Such places support unique biomes where many new microbes and other lifeforms have been discovered.[95]

Humans have travelled the seas since they first built sea-going craft. Mesopotamians were using bitumen to caulk their reed boats and, a little later, masted sails.[96] By c. 3000 BC, Austronesians on Taiwan had begun spreading into maritime Southeast Asia.[97] Subsequently, the Austronesian "Lapita" peoples displayed great feats of navigation, reaching out from the Bismarck Archipelago to as far away as Fiji, Tonga, and Samoa.[98] Their descendants continued to travel thousands of miles between tiny islands on outrigger canoes,[99] and in the process they found many new islands, including Hawaii, Easter Island (Rapa Nui), and New Zealand.[100]

The Ancient Egyptians and Phoenicians explored the Mediterranean and Red Sea with the Egyptian Hannu reaching the Arabian Peninsula and the African Coast around 2750 BC.[101] In the first millennium BC, Phoenicians and Greeks established colonies throughout the Mediterranean and the Black Sea.[102] Around 500 BC, the Carthaginian navigator Hanno left a detailed periplus of an Atlantic journey that reached at least Senegal and possibly Mount Cameroon.[103][104] In the early Mediaeval period, the Vikings crossed the North Atlantic and even reached the northeastern fringes of North America.[105] Novgorodians had also been sailing the White Sea since the 13th century or before.[106] Meanwhile, the seas along the eastern and southern Asian coast were used by Arab and Chinese traders.[107] The Chinese Ming Dynasty had a fleet of 317 ships with 37,000 men under Zheng He in the early fifteenth century, sailing the Indian and Pacific Oceans.[3]:1213 In the late fifteenth century, Western European mariners started making longer voyages of exploration in search of trade. Bartolomeu Dias rounded the Cape of Good Hope in 1487 and Vasco da Gama reached India via the Cape in 1498. Christopher Columbus sailed from Cadiz in 1492, attempting to reach the eastern lands of India and Japan by the novel means of travelling westwards. He made landfall instead on an island in the Caribbean Sea and a few years later, the Venetian navigator John Cabot reached Newfoundland. The Italian Amerigo Vespucci, after whom America was named, explored the South American coastline in voyages made between 1497 and 1502, discovering the mouth of the Amazon River.[3]:1213 In 1519 the Portuguese navigator Ferdinand Magellan led the Spanish Magellan-Elcano expedition which would be the first to sail around the world.[3]:1213

As for the history of navigational instrument, a compass was first used by the ancient Greeks and Chinese to show where north lies and the direction in which the ship is heading. The latitude (an angle which ranges from 0 at the equator to 90 at the poles) was determined by measuring the angle between the Sun, Moon or a specific star and the horizon by the use of an astrolabe, Jacob's staff or sextant. The longitude (a line on the globe joining the two poles) could only be calculated with an accurate chronometer to show the exact time difference between the ship and a fixed point such as the Greenwich Meridian. In 1759, John Harrison, a clockmaker, designed such an instrument and James Cook used it in his voyages of exploration.[108] Nowadays, the Global Positioning System (GPS) using over thirty satellites enables accurate navigation worldwide.[108]

With regards to maps that are vital for navigation, in the second century, Ptolemy mapped the whole known world from the "Fortunatae Insulae", Cape Verde or Canary Islands, eastward to the Gulf of Thailand. This map was used in 1492 when Christopher Columbus set out on his voyages of discovery.[109] Subsequently, Gerardus Mercator made a practical map of the world in 1538, his map projection conveniently making rhumb lines straight.[3]:1213 By the eighteenth century better maps had been made and part of the objective of James Cook on his voyages was to further map the ocean. Scientific study has continued with the depth recordings of the Tuscarora, the oceanic research of the Challenger voyages (18721876), the work of the Scandinavian seamen Roald Amundsen and Fridtjof Nansen, the Michael Sars expedition in 1910, the German Meteor expedition of 1925, the Antarctic survey work of Discovery II in 1932, and others since.[19] Furthermore, in 1921, the International Hydrographic Organization (IHO) was set up, and it constitutes the world authority on hydrographic surveying and nautical charting.[110] A fourth edition draft was published in 1986 but so far several naming disputes (such as the one over the Sea of Japan) have prevented its ratification.

Scientific oceanography began with the voyages of Captain James Cook from 1768 to 1779, describing the Pacific with unprecedented precision from 71 degrees South to 71 degrees North.[3]:14 John Harrison's chronometers supported Cook's accurate navigation and charting on two of these voyages, permanently improving the standard attainable for subsequent work.[3]:14 Other expeditions followed in the nineteenth century, from Russia, France, the Netherlands and the United States as well as Britain.[3]:15 On HMS Beagle, which provided Charles Darwin with ideas and materials for his 1859 book On the Origin of Species, the ship's captain, Robert FitzRoy, charted the seas and coasts and published his four-volume report of the ship's three voyages in 1839.[3]:15 Edward Forbes's 1854 book, Distribution of Marine Life argued that no life could exist below around 600 metres (2000 feet). This was proven wrong by the British biologists W. B. Carpenter and C. Wyville Thomson, who in 1868 discovered life in deep water by dredging.[3]:15 Wyville Thompson became chief scientist on the Challenger expedition of 18721876, which effectively created the science of oceanography.[3]:15

On her 68,890-nautical-mile (127,580km) journey round the globe, HMS Challenger discovered about 4,700 new marine species, and made 492 deep sea soundings, 133 bottom dredges, 151 open water trawls and 263 serial water temperature observations.[111] In the southern Atlantic in 1898/1899, Carl Chun on the Valdivia brought many new life forms to the surface from depths of over 4,000 metres (13,000ft). The first observations of deep-sea animals in their natural environment were made in 1930 by William Beebe and Otis Barton who descended to 434 metres (1,424ft) in the spherical steel Bathysphere.[citation needed] This was lowered by cable but by 1960 a self-powered submersible, Trieste developed by Jacques Piccard, took Piccard and Don Walsh to the deepest part of the Earth's oceans, the Mariana Trench in the Pacific, reaching a record depth of about 10,915 metres (35,810ft),[112] a feat not repeated until 2012 when James Cameron piloted the Deepsea Challenger to similar depths.[113] An atmospheric diving suit can be worn for deep sea operations, with a new world record being set in 2006 when a US Navy diver descended to 2,000 feet (610m) in one of these articulated, pressurized suits.[114]

At great depths, no light penetrates through the water layers from above and the pressure is extreme. For deep sea exploration it is necessary to use specialist vehicles, either remotely operated underwater vehicles with lights and cameras or crewed submersibles. The battery-operated Mir submersibles have a three-person crew and can descend to 20,000 feet (6,000m). They have viewing ports, 5,000-watt lights, video equipment and manipulator arms for collecting samples, placing probes or pushing the vehicle across the sea bed when the thrusters would stir up excessive sediment.[115]

Bathymetry is the mapping and study of the topography of the ocean floor. Methods used for measuring the depth of the sea include single or multibeam echosounders, laser airborne depth sounders and the calculation of depths from satellite remote sensing data. This information is used for determining the routes of undersea cables and pipelines, for choosing suitable locations for siting oil rigs and offshore wind turbines and for identifying possible new fisheries.[116]

Ongoing oceanographic research includes marine lifeforms, conservation, the marine environment, the chemistry of the ocean, the studying and modelling of climate dynamics, the air-sea boundary, weather patterns, ocean resources, renewable energy, waves and currents, and the design and development of new tools and technologies for investigating the deep.[117] Whereas in the 1960s and 1970s research could focus on taxonomy and basic biology, in the 2010s attention has shifted to larger topics such as climate change.[118] Researchers make use of satellite-based remote sensing for surface waters, with research ships, moored observatories and autonomous underwater vehicles to study and monitor all parts of the sea.[119]

"Freedom of the seas" is a principle in international law dating from the seventeenth century. It stresses freedom to navigate the oceans and disapproves of war fought in international waters.[120] Today, this concept is enshrined in the United Nations Convention on the Law of the Sea (UNCLOS), the third version of which came into force in 1994. Article 87(1) states: "The high seas are open to all states, whether coastal or land-locked." Article 87(1) (a) to (f) gives a non-exhaustive list of freedoms including navigation, overflight, the laying of submarine cables, building artificial islands, fishing and scientific research.[120] The safety of shipping is regulated by the International Maritime Organization. Its objectives include developing and maintaining a regulatory framework for shipping, maritime safety, environmental concerns, legal matters, technical co-operation and maritime security.[121]

UNCLOS defines various areas of water. "Internal waters" are on the landward side of a baseline and foreign vessels have no right of passage in these. "Territorial waters" extend to 12nautical miles (22kilometres; 14miles) from the coastline and in these waters, the coastal state is free to set laws, regulate use and exploit any resource. A "contiguous zone" extending a further 12nautical miles allows for hot pursuit of vessels suspected of infringing laws in four specific areas: customs, taxation, immigration and pollution. An "exclusive economic zone" extends for 200nautical miles (370kilometres; 230miles) from the baseline. Within this area, the coastal nation has sole exploitation rights over all natural resources. The "continental shelf" is the natural prolongation of the land territory to the continental margin's outer edge, or 200 nautical miles from the coastal state's baseline, whichever is greater. Here the coastal nation has the exclusive right to harvest minerals and also living resources "attached" to the seabed.[120]

Control of the sea is important to the security of a maritime nation, and the naval blockade of a port can be used to cut off food and supplies in time of war. Battles have been fought on the sea for more than 3,000 years. In about 1210 B.C., Suppiluliuma II, the king of the Hittites, defeated and burned a fleet from Alashiya (modern Cyprus).[122] In the decisive 480 B.C. Battle of Salamis, the Greek general Themistocles trapped the far larger fleet of the Persian king Xerxes in a narrow channel and attacked vigorously, destroying 200 Persian ships for the loss of 40 Greek vessels.[123] At the end of the Age of Sail, the British Royal Navy, led by Horatio Nelson, broke the power of the combined French and Spanish fleets at the 1805 Battle of Trafalgar.[124]

With steam and the industrial production of steel plate came greatly increased firepower in the shape of the dreadnought battleships armed with long-range guns. In 1905, the Japanese fleet decisively defeated the Russian fleet, which had travelled over 18,000 nautical miles (33,000km), at the Battle of Tsushima.[125] Dreadnoughts fought inconclusively in the First World War at the 1916 Battle of Jutland between the Royal Navy's Grand Fleet and the Imperial German Navy's High Seas Fleet.[126] In the Second World War, the British victory at the 1940 Battle of Taranto showed that naval air power was sufficient to overcome the largest warships,[127] foreshadowing the decisive sea-battles of the Pacific War including the Battles of the Coral Sea, Midway, the Philippine Sea, and the climactic Battle of Leyte Gulf, in all of which the dominant ships were aircraft carriers.[128][129]

Submarines became important in naval warfare in World War I, when German submarines, known as U-boats, sank nearly 5,000 Allied merchant ships,[130] including the RMS Lusitania, which helped to bring the United States into the war.[131] In World War II, almost 3,000 Allied ships were sunk by U-boats attempting to block the flow of supplies to Britain,[132] but the Allies broke the blockade in the Battle of the Atlantic, which lasted the whole length of the war, sinking 783 U-boats.[133] Since 1960, several nations have maintained fleets of nuclear-powered ballistic missile submarines, vessels equipped to launch ballistic missiles with nuclear warheads from under the sea. Some of these are kept permanently on patrol.[134][135]

Sailing ships or packets carried mail overseas, one of the earliest being the Dutch service to Batavia in the 1670s.[136] These added passenger accommodation, but in cramped conditions. Later, scheduled services were offered but the time journeys took depended much on the weather. When steamships replaced sailing vessels, ocean-going liners took over the task of carrying people. By the beginning of the twentieth century, crossing the Atlantic took about five days and shipping companies competed to own the largest and fastest vessels. The Blue Riband was an unofficial accolade given to the fastest liner crossing the Atlantic in regular service. The Mauretania held the title with 26.06 knots (48.26km/h) for twenty years from 1909.[137] The Hales Trophy, another award for the fastest commercial crossing of the Atlantic, was won by the United States in 1952 for a crossing that took three days, ten hours and forty minutes.[138]

The great liners were comfortable but expensive in fuel and staff. The age of the trans-Atlantic liners waned as cheap intercontinental flights became available. In 1958, a regular scheduled air service between New York and Paris taking seven hours doomed the Atlantic ferry service to oblivion. One by one the vessels were laid up, some were scrapped, others became cruise ships for the leisure industry and still others floating hotels.[139]

Maritime trade has existed for millennia. The Ptolemaic dynasty had developed trade with India using the Red Sea ports and in the first millennium BC the Arabs, Phoenicians, Israelites and Indians traded in luxury goods such as spices, gold, and precious stones.[140] The Phoenicians were noted sea traders and under the Greeks and Romans, commerce continued to thrive. With the collapse of the Roman Empire, European trade dwindled but it continued to flourish among the kingdoms of Africa, the Middle East, India, China and southeastern Asia.[141] From the 16th to the 19th centuries, over a period of 400 years, about 1213million Africans were shipped across the Atlantic to be sold as slaves in the Americas as part of the Atlantic slave trade.[142][143]:194

Large quantities of goods are transported by sea, especially across the Atlantic and around the Pacific Rim. A major trade route passes through the Pillars of Hercules, across the Mediterranean and the Suez Canal to the Indian Ocean and through the Straits of Malacca; much trade also passes through the English Channel.[144] Shipping lanes are the routes on the open sea used by cargo vessels, traditionally making use of trade winds and currents. Over 60 percent of the world's container traffic is conveyed on the top twenty trade routes.[145] Increased melting of Arctic ice since 2007 enables ships to travel the Northwest Passage for some weeks in summertime, avoiding the longer routes via the Suez Canal or the Panama Canal.[146]Shipping is supplemented by air freight, a more expensive process mostly used for particularly valuable or perishable cargoes. Seaborne trade carries more than US$4 trillion worth of goods each year.[147] Bulk cargo in the form of liquids, powder or particles are carried loose in the holds of bulk carriers and include crude oil, grain, coal, ore, scrap metal, sand and gravel.[148] Other cargo, such as manufactured goods, is usually transported within standard sized, lockable containers, loaded on purpose-built container ships at dedicated terminals.[149] Before the rise of containerization in the 1960s, these goods were loaded, transported and unloaded piecemeal as break-bulk cargo. Containerization greatly increased the efficiency and decreased the cost of moving goods by sea, and was a major factor leading to the rise of globalization and exponential increases in international trade in the mid-to-late 20th century.[150]

Fish and other fishery products are among the most widely consumed sources of protein and other essential nutrients.[151] In 2009, 16.6% of the world's intake of animal protein and 6.5% of all protein consumed came from fish.[151] In order to fulfill this need, coastal countries have exploited marine resources in their exclusive economic zone, although fishing vessels are increasingly venturing further afield to exploit stocks in international waters.[152] In 2011, the total world production of fish, including aquaculture, was estimated to be 154million tonnes, of which most was for human consumption.[151] The harvesting of wild fish accounted for 90.4million tonnes, while annually increasing aquaculture contributes the rest.[151] The north west Pacific is by far the most productive area with 20.9 million tonnes (27 percent of the global marine catch) in 2010.[151] In addition, the number of fishing vessels in 2010 reached 4.36 million, whereas the number of people employed in the primary sector of fish production in the same year amounted to 54.8 million.[151]

Modern fishing vessels include fishing trawlers with a small crew, stern trawlers, purse seiners, long-line factory vessels and large factory ships which are designed to stay at sea for weeks, processing and freezing great quantities of fish. The equipment used to capture the fish may be purse seines, other seines, trawls, dredges, gillnets and long-lines and the fish species most frequently targeted are herring, cod, anchovy, tuna, flounder, mullet, squid and salmon. Overexploitation has become a serious concern; it does not only cause the depletion of fish stocks, but also substantially reduce the size of predatory fish populations.[153] It has been estimated that "industrialized fisheries typically reduced community biomass by 80% within 15 years of exploitation."[153] In order to avoid overexploitation, many countries have introduced quotas in their own waters.[154] However, recovery efforts often entail substantial costs to local economies or food provision.

Artisan fishing methods include rod and line, harpoons, skin diving, traps, throw nets and drag nets. Traditional fishing boats are powered by paddle, wind or outboard motors and operate in near-shore waters. The Food and Agriculture Organization is encouraging the development of local fisheries to provide food security to coastal communities and help alleviate poverty.[155]

About 79million tonnes (78M long tons; 87M short tons) of food and non-food products were produced by aquaculture in 2010, an all-time high. About six hundred species of plants and animals were cultured, some for use in seeding wild populations. The animals raised included finfish, aquatic reptiles, crustaceans, molluscs, sea cucumbers, sea urchins, sea squirts and jellyfish.[151] Integrated mariculture has the advantage that there is a readily available supply of planktonic food in the ocean, and waste is removed naturally.[156] Various methods are employed. Mesh enclosures for finfish can be suspended in the open seas, cages can be used in more sheltered waters or ponds can be refreshed with water at each high tide. Shrimps can be reared in shallow ponds connected to the open sea.[157] Ropes can be hung in water to grow algae, oysters and mussels. Oysters can be reared on trays or in mesh tubes. Sea cucumbers can be ranched on the seabed.[158] Captive breeding programmes have raised lobster larvae for release of juveniles into the wild resulting in an increased lobster harvest in Maine.[159] At least 145 species of seaweed red, green, and brown algae are eaten worldwide, and some have long been farmed in Japan and other Asian countries; there is great potential for additional algaculture.[160] Few maritime flowering plants are widely used for food but one example is marsh samphire which is eaten both raw and cooked.[161] A major difficulty for aquaculture is the tendency towards monoculture and the associated risk of widespread disease. Aquaculture is also associated with environmental risks; for instance, shrimp farming has caused the destruction of important mangrove forests throughout southeast Asia.[162]

Use of the sea for leisure developed in the nineteenth century, and became a significant industry in the twentieth century.[163] Maritime leisure activities are varied, and include self-organized trips cruising, yachting, powerboat racing[164] and fishing;[165] commercially organized voyages on cruise ships;[166] and trips on smaller vessels for ecotourism such as whale watching and coastal birdwatching.[167]

Sea bathing became the vogue in Europe in the 18th century after Dr. William Buchan advocated the practice for health reasons.[168] Surfing is a sport in which a wave is ridden by a surfer, with or without a surfboard. Other marine water sports include kite surfing, where a power kite propels a rider on a board across the water,[169] windsurfing, where the power is provided by a fixed, manoeuvrable sail[170] and water skiing, where a powerboat is used to pull a skier.[171]

Beneath the surface, freediving is necessarily restricted to shallow descents. Pearl divers can dive to 40 feet (12m) with baskets to collect oysters.[172] Human eyes are not adapted for use underwater but vision can be improved by wearing a diving mask. Other useful equipment includes fins and snorkels, and scuba equipment allows underwater breathing and hence a longer time can be spent beneath the surface.[173] The depths that can be reached by divers and the length of time they can stay underwater is limited by the increase of pressure they experience as they descend and the need to prevent decompression sickness as they return to the surface. Recreational divers restrict themselves to depths of 100 feet (30m) beyond which the danger of nitrogen narcosis increases. Deeper dives can be made with specialised equipment and training.[173]

The sea offers a very large supply of energy carried by ocean waves, tides, salinity differences, and ocean temperature differences which can be harnessed to generate electricity.[174] Forms of sustainable marine energy include tidal power, ocean thermal energy and wave power.[174][175] Electricity power stations are often located on the coast or beside an estuary so that the sea can be used as a heat sink. A colder heat sink enables more efficient power generation, which is important for expensive nuclear power plants in particular.[176]

Tidal power uses generators to produce electricity from tidal flows, sometimes by using a dam to store and then release seawater. The Rance barrage, 1 kilometre (0.62mi) long, near St Malo in Brittany opened in 1967; it generates about 0.5 GW, but it has been followed by few similar schemes.[3]:111112

The large and highly variable energy of waves gives them enormous destructive capability, making affordable and reliable wave machines problematic to develop. A small 2 MW commercial wave power plant, "Osprey", was built in Northern Scotland in 1995 about 300metres (1000ft) offshore. It was soon damaged by waves, then destroyed by a storm.[3]:112

Offshore wind power is captured by wind turbines placed out at sea; it has the advantage that wind speeds are higher than on land, though wind farms are more costly to construct offshore.[177] The first offshore wind farm was installed in Denmark in 1991,[178] and the installed capacity of worldwide offshore wind farms reached 34 GW in 2020, mainly situated in Europe.[179]

The seabed contains large reserves of minerals which can be exploited by dredging. This has advantages over land-based mining in that equipment can be built at specialised shipyards and infrastructure costs are lower. Disadvantages include problems caused by waves and tides, the tendency for excavations to silt up and the washing away of spoil heaps. There is a risk of coastal erosion and environmental damage.[180]

Seafloor massive sulphide deposits are potential sources of silver, gold, copper, lead and zinc and trace metals since their discovery in the 1960s. They form when geothermally heated water is emitted from deep sea hydrothermal vents known as "black smokers". The ores are of high quality but prohibitively costly to extract.[181]

There are large deposits of petroleum, as oil and natural gas, in rocks beneath the seabed. Offshore platforms and drilling rigs extract the oil or gas and store it for transport to land. Offshore oil and gas production can be difficult due to the remote, harsh environment.[182] Drilling for oil in the sea has environmental impacts. Animals may be disorientated by seismic waves used to locate deposits, and there is debate as to whether this causes the beaching of whales.[183] Toxic substances such as mercury, lead and arsenic may be released. The infrastructure may cause damage, and oil may be spilt.[184]

Large quantities of methane clathrate exist on the seabed and in ocean sediment, of interest as a potential energy source.[185] Also on the seabed are manganese nodules formed of layers of iron, manganese and other hydroxides around a core. In the Pacific these may cover up to 30 percent of the deep ocean floor. The minerals precipitate from seawater and grow very slowly. Their commercial extraction for nickel was investigated in the 1970s but abandoned in favour of more convenient sources.[186] In suitable locations, diamonds are gathered from the seafloor using suction hoses to bring gravel ashore. In deeper waters, mobile seafloor crawlers are used and the deposits are pumped to a vessel above. In Namibia, more diamonds are now collected from marine sources than by conventional methods on land.[187]

The sea holds large quantities of valuable dissolved minerals.[188] The most important, Salt for table and industrial use has been harvested by solar evaporation from shallow ponds since prehistoric times. Bromine, accumulated after being leached from the land, is economically recovered from the Dead Sea, where it occurs at 55,000 parts per million (ppm).[189]

Desalination is the technique of removing salts from seawater to leave fresh water suitable for drinking or irrigation. The two main processing methods, vacuum distillation and reverse osmosis, use large quantities of energy. Desalination is normally only undertaken where fresh water from other sources is in short supply or energy is plentiful, as in the excess heat generated by power stations. The brine produced as a by-product contains some toxic materials and is returned to the sea.[190]

Several nomadic indigenous groups in Maritime Southeast Asia live in boats and derive nearly all they need from the sea. The Moken people live on the coasts of Thailand and Burma and islands in the Andaman Sea.[191] The Bajau people are originally from the Sulu Archipelago, Mindanao and northern Borneo.[citation needed] Some Sea Gypsies are accomplished free-divers, able to descend to depths of 30 metres (98ft), though many are adopting a more settled, land-based way of life.[192][193]

The indigenous peoples of the Arctic such as the Chukchi, Inuit, Inuvialuit and Yup'iit hunt marine mammals including seals and whales,[194] and the Torres Strait Islanders of Australia include the Great Barrier Reef among their possessions. They live a traditional life on the islands involving hunting, fishing, gardening and trading with neighbouring peoples in Papua and mainland Aboriginal Australians.[195]

The sea appears in human culture in contradictory ways, as both powerful but serene and as beautiful but dangerous.[3]:10 It has its place in literature, art, poetry, film, theatre, classical music, mythology and dream interpretation.[196] The Ancients personified it, believing it to be under the control of a being who needed to be appeased, and symbolically, it has been perceived as a hostile environment populated by fantastic creatures; the Leviathan of the Bible,[197] Scylla in Greek mythology,[198] Isonade in Japanese mythology,[199] and the kraken of late Norse mythology.[200]

The sea and ships have been depicted in art ranging from simple drawings on the walls of huts in Lamu[196] to seascapes by Joseph Turner. In Dutch Golden Age painting, artists such as Jan Porcellis, Hendrick Dubbels, Willem van de Velde the Elder and his son, and Ludolf Bakhuizen celebrated the sea and the Dutch navy at the peak of its military prowess.[201][202] The Japanese artist Katsushika Hokusai created colour prints of the moods of the sea, including The Great Wave off Kanagawa.[3]:8

Music too has been inspired by the ocean, sometimes by composers who lived or worked near the shore and saw its many different aspects. Sea shanties, songs that were chanted by mariners to help them perform arduous tasks, have been woven into compositions and impressions in music have been created of calm waters, crashing waves and storms at sea.[203]:48

As a symbol, the sea has for centuries played a role in literature, poetry and dreams. Sometimes it is there just as a gentle background but often it introduces such themes as storm, shipwreck, battle, hardship, disaster, the dashing of hopes and death.[203]:45 In his epic poem the Odyssey, written in the eighth century BC,[204] Homer describes the ten-year voyage of the Greek hero Odysseus who struggles to return home across the sea's many hazards after the war described in the Iliad.[205] The sea is a recurring theme in the Haiku poems of the Japanese Edo period poet Matsuo Bash ( ) (16441694).[206] In the works of psychiatrist Carl Jung, the sea symbolizes the personal and the collective unconscious in dream interpretation, the depths of the sea symbolizing the depths of the unconscious mind.[207]

Human activities affect marine life and marine habitats through overfishing, habitat loss, the introduction of invasive species, ocean pollution, ocean acidification and ocean warming. These impact marine ecosystems and food webs and may result in consequences as yet unrecognised for the biodiversity and continuation of marine life forms.[208]

Seawater is slightly alkaline and had an average pH of about 8.2 over the past 300 million years.[209] More recently, climate change has resulted in an increase of the carbon dioxide content of the atmosphere; about 3040% of the added CO2 is absorbed by the oceans, forming carbonic acid and lowering the pH (now below 8.1[209]) through a process called ocean acidification.[210][211][212] The pH is expected to reach 7.7 (representing a 3-fold increase in hydrogen ion concentration) by the year 2100, which is a significant change in a century.[213][e]

One important element for the formation of skeletal material in marine animals is calcium, but calcium carbonate becomes more soluble with pressure, so carbonate shells and skeletons dissolve below its compensation depth.[215] Calcium carbonate also becomes more soluble at lower pH, so ocean acidification is likely to have profound effects on marine organisms with calcareous shells, such as oysters, clams, sea urchins, and corals,[216] because their ability to form shells will be reduced,[217] and the carbonate compensation depth will rise closer to the sea surface. Affected planktonic organisms will include the snail-like molluscs known as pteropods, and single-celled algae called coccolithophorids and foraminifera. All of these are important parts of the food chain and a diminution in their numbers will have significant consequences. In tropical regions, corals are likely to be severely affected as it becomes more difficult to build their calcium carbonate skeletons,[218] in turn adversely impacting other reef dwellers.[213]

The current rate of ocean chemistry change appears to be without precedent in Earth's geological history, making it unclear how well marine ecosystems will be able to adapt to the shifting conditions of the near future.[219] Of particular concern is the manner in which the combination of acidification with the expected additional stressors of higher temperatures and lower oxygen levels will impact the seas.[220]

Many substances enter the sea as a result of human activities. Combustion products are transported in the air and deposited into the sea by precipitation. Industrial outflows and sewage contribute heavy metals, pesticides, PCBs, disinfectants, household cleaning products and other synthetic chemicals. These become concentrated in the surface film and in marine sediment, especially estuarine mud. The result of all this contamination is largely unknown because of the large number of substances involved and the lack of information on their biological effects.[221] The heavy metals of greatest concern are copper, lead, mercury, cadmium and zinc which may be bio-accumulated by marine organisms and are passed up the food chain.[222]

Much floating plastic rubbish does not biodegrade, instead disintegrating over time and eventually breaking down to the molecular level. Rigid plastics may float for years.[223] In the centre of the Pacific gyre there is a permanent floating accumulation of mostly plastic waste[224] and there is a similar garbage patch in the Atlantic.[225] Foraging sea birds such as the albatross and petrel may mistake debris for food, and accumulate indigestible plastic in their digestive systems. Turtles and whales have been found with plastic bags and fishing line in their stomachs. Microplastics may sink, threatening filter feeders on the seabed.[226]

Most oil pollution in the sea comes from cities and industry.[227] Oil is dangerous for marine animals. It can clog the feathers of sea birds, reducing their insulating effect and the birds' buoyancy, and be ingested when they preen themselves in an attempt to remove the contaminant. Marine mammals are less seriously affected but may be chilled through the removal of their insulation, blinded, dehydrated or poisoned. Benthic invertebrates are swamped when the oil sinks, fish are poisoned and the food chain is disrupted. In the short term, oil spills result in wildlife populations being decreased and unbalanced, leisure activities being affected and the livelihoods of people dependent on the sea being devastated.[228] The marine environment has self-cleansing properties and naturally occurring bacteria will act over time to remove oil from the sea. In the Gulf of Mexico, where oil-eating bacteria are already present, they take only a few days to consume spilt oil.[229]

Run-off of fertilisers from agricultural land is a major source of pollution in some areas and the discharge of raw sewage has a similar effect. The extra nutrients provided by these sources can cause excessive plant growth. Nitrogen is often the limiting factor in marine systems, and with added nitrogen, algal blooms and red tides can lower the oxygen level of the water and kill marine animals. Such events have created dead zones in the Baltic Sea and the Gulf of Mexico.[227] Some algal blooms are caused by cyanobacteria that make shellfish that filter feed on them toxic, harming animals like sea otters.[230] Nuclear facilities too can pollute. The Irish Sea was contaminated by radioactive caesium-137 from the former Sellafield nuclear fuel processing plant[231] and nuclear accidents may also cause radioactive material to seep into the sea, as did the disaster at the Fukushima Daiichi Nuclear Power Plant in 2011.[232]

The dumping of waste (including oil, noxious liquids, sewage and garbage) at sea is governed by international law. The London Convention (1972) is a United Nations agreement to control ocean dumping which had been ratified by 89 countries by 8 June 2012.[233] MARPOL 73/78 is a convention to minimize pollution of the seas by ships. By May 2013, 152 maritime nations had ratified MARPOL.[234]

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Brevard Zoo Sea Turtle Healing Center Prepares for 200th Turtle Release …

turtle set to be returned to the ocean at 11:30 a.m.BREVARD ZOO: We are thrilled to share with you that our Sea Turtle Healing Center is gearing up to release its 200th sea turtle. Sub-adult green sea turtle Hope is set to be returned to the ocean on Wednesday, January 25 at 11:30 a.m. at Lori Wilson Park in Cocoa Beach following a successful rehabilitation stint at our Healing Center. (Brevard Zoo image)

By Brevard Zoo

BREVARD COUNTY, FLORIDA We are thrilled to share with you that our Sea Turtle Healing Center is gearing up to release its 200th sea turtle.

Sub-adult green sea turtle Hope is set to be returned to the ocean on Wednesday, January 25 at 11:30 a.m. at Lori Wilson Park in Cocoa Beach following a successful rehabilitation stint at our Healing Center.

To mark this extra special occasion, were planning our biggest release celebration to date.

Green sea turtle Hope is a sub-adult green sea turtle that was found in Indian River County.

Our Healing Center actually receives about 18 percent of its patients from this county!

Volunteers with Coastal Connections, a nonprofit that works to protect sea turtles and their habitats, responded to Hopes stranding and brought them to the Healing Center on November 19 helped in part by the Sea Turtle Preservation Society.

Our Healing Center team found that Hope was extremely buoyant making her unable to dive. A sea turtle who is unable to dive may find it difficult to avoid predators, boats, and other hazards.

To get a full look at Hopes health, the green sea turtle received radiographs, blood evaluation, physical examination, antibiotics, fluid therapy, and a CT scan at Rockledge Regional Medical Center. Hope was treated for an inflammation of the digestive tract.

Hope will be remembered by our Healing Center team as a sassy sub-adult with a great fight or flight instinct. This turtle is ready to go home to the ocean!

The theme for this release is a quote from marine biologist Sylvia Earle, No water, no life. No blue, no green. Were encouraging all release attendees to wear blue or green to celebrate Hopes return.

To celebrate Hopes release, a special presentation of Brevard Zoos Turtle Tech initiative will take place just before the release at 10:30 a.m. on January 25.

One of Turtle Techs goals is to develop and advance technologies, including unmanned drone flights, which will lead to a better understanding of the sea turtle species here in Florida and around the world.

One of these unmanned flights or Beyond Visual Line of Site (BLVOS) flights will take place by our Turtle Tech partner Embry-Riddle Aeronautical University where they will video of Hopes release.

This project is a collaboration among the Brevard Zoo, local engineers, Florida universities, Brevard County Public Schools, and other organizations, and is supported by a generous grant from the Northrop Grumman Foundation.

This release is open to the public, meaning you can witness Hope being returned to the ocean! Join us on Wednesday, January 25 at Lori Wilson Park in Cocoa Beach for this special sendoff.

Please note that we plan to have this turtles flippers in the water at 11:30 a.m. If you plan to attend, we suggest getting there early.

Not only will this help you secure parking and a spot on the beach, but it will also give you time to check out some of the awesome informational tables set up.

Hope will be released on the North side of Lori Wilson Park, but we would encourage those attending to utilize both the North and South parking lots.

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King tides to bring extremely high sea levels, but is flooding again a …

A second round of king tides land this weekend, with high tides nearing 7 feet. The National Weather Service has issued warnings for low-lying areas along Orange and Los Angeles counties through Monday morning.

The morning high tides could result in minor tidal overflow, bringing some ponding of sea water to vulnerable areas, including parking lots at low-lying beach areas, a coastal hazard advisory says.

Beach goers walk across the groomed beach just north of the Seal Beach Pier in Seal Beach on Friday morning, January 20, 203. A round of high tides are expected to hit this weekend which could mean some flooding in lower locations along the coast. (Photo by Mark Rightmire, Orange County Register/SCNG)

Beach goers take in the view of ships offshore from the sand berm put in place to protect homes and streets from flooding just south of the Seal Beach Pier in Seal Beach on Friday morning, January 20, 203. A round of high tides are expected to hit this weekend which could mean some flooding in lower locations along the coast. (Photo by Mark Rightmire, Orange County Register/SCNG)

A woman walks along the groomed beach in Seal Beach on Friday morning, January 20, 203. A round of high tides are expected to hit this weekend which could mean some flooding in lower locations along the coast. (Photo by Mark Rightmire, Orange County Register/SCNG)

Gulls take to the air as a beach goer takes video of their flight on the beach in Seal Beach on Friday morning, January 20, 203. A round of high tides are expected to hit this weekend which could mean some flooding in lower locations along the coast. (Photo by Mark Rightmire, Orange County Register/SCNG)

The good news is the surf will be small, unlike a week ago when high tide and big surf combined to cause damage along the coast.

Significant damage to roads or structures is not expected, National Weather Service officials said.

The morning high tides are expected to hit 6.96 feet around 8 a.m. on Saturday and 6.93 feet at about 8:50 a.m. on Sunday. On the flip side, extreme low tides will see the ocean recede to negative levels in the afternoon hours, leaving more sand space and a great opportunity to explore tide pools throughout the region.

Trouble areas during high tide this weekend could include Surfside and Sunset Beach, Newport Beach, the Malibu coast and Los Angeles County beaches, the National Weather Service warned.

A parade of storms, a big westerly swell and higher tide events already caused problems at several beaches in recent weeks.

The road and a restroom building continue to be a concern at Point Dume, as well as a landslide area below Palos Verdes Estates, and crews will be closely monitoring things this weekend, said Nicole Mooradian, spokesperson for Los Angeles County Department of Beaches & Harbors.

Beachgoers should be mindful of sharp drop-offs at the tideline due to sand erosion and check where the nearest open lifeguard tower is, because some have been moved to protect them from flooding, Mooradian noted.

The Roundhouse Aquarium is hosting a King Tide Watch at the end of the Manhattan Beach Pier from 8:30 to 9:15 a.m. on Sunday, Jan. 22, to help community and climate scientists document the natural phenomenon.

The idea is to capture photos of the oceans tide at the precise moment of the most intense gravitational force on the ocean, organizers said. Discussions about the relationship between sea level rise and climate change will take place.

The gathering is part of a larger effort called the California King Tides Project to document the impact of the higher tides on the coastline.

King tides refer to the years highest tides in winter months, which are a natural, predictable phenomenon that pushes tides one to two feet higher than an average high tide.

Scientists predict this will be what daily tides are like in the next few decades because of sea level rise.

Photographing these extreme high tides brings attention to the impact of climate change and helps California plan for a future when todays king tide is an everyday occurrence, the California King Tides Project said in an announcement.

The project encourages citizen scientists to get involved and says their photos are used by state and local officials, as well as climate change researchers, to validate sea level rise models and assess local flood vulnerabilities.

For past king tides photos, information on how to upload your own photos, local king tide times, local community events and resources for educators teaching about climate change, go to coastal.ca.gov/kingtides.

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King tides to bring extremely high sea levels, but is flooding again a ...

A man accidentally drifted out to sea with only ketchup and seasonings …

A 47-year-old man was working on his boat in St. Maarten in December when the weather suddenly churned and he drifted out to sea. He soon became lost and now, weeks later has been found off the coast of Colombia with only ketchup and seasonings helping to keep him nourished.

The Colombian Navy announced Wednesday that they rescued the man, identified as Elvis Francois of Dominica, about 120 nautical miles away from Puerto Bolvar in the Caribbean Sea. They responded to the stranded man after learning that there was an adrift sailboat with the word "HELP" spelled out on the boat's hull.

The navy said that Francois informed them he had been near Saint Maarten in the Antilles islands making repairs on his boat when weather conditions worsened and he was suddenly dragged out to sea. Authorities said that Francois' navigation skills were not keen, making him lost and disoriented.

"I tried to [go] back to port, but I lost track because it took me a while to mount the sail and fix the sail," Francois said in a video released by the Navy. "...I call my friends, my coworkers. They tried to contact me, but they lost service. There was nothing else I could do than sit down and wait."

That's when he decided to write out a call for help on the back of the boat.

"I had no food, just a bottle of ketchup that was on the boat, garlic powder and Maggi [soup]," he said. "So, I mixed it up with some water so I had this to survive for 24 days in the sea."

Upon rescue, Francois was taken to the Port of Cartagena to receive medical care and begin procedures to return to Dominica, the navy said. Colombian Army Commander Captain Carlos Urano Montes said that he "was found to be in good health."

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A man accidentally drifted out to sea with only ketchup and seasonings ...

Sea gnawing away at Karnataka beaches, coasts

Express News Service

KARWAR/UDUPI(KARNATAKA: Sea erosion is increasing every year on the West Coast, particularly in Uttara Kannada, where it was so far considered not a serious issue. While experts say the erosion is due to global warming, beaches will soon be lost and thousands of fishermen will be badly affected. They have stressed on proper long-term planning to protect the coast and its economy.

In mid-2022, the people at Thappalakere village in Bhatkal of Uttara Kannada district made it to the headlines when they approached the Human Rights Commission, demanding a solution to theirannual problem sea erosion. They have been suffering because for the last 4-5 years. The problem became so severe that Chief Minister Basavraj Bommai, scheduled to visit here, cancelled his trip on being advised against it, as sea erosion has severely damaged roads, making them unmotorable.

Taranath Rathod, Superintendent Engineer, Department of Ports, says, Thappalakere is a low-lying area and houses get flooded during monsoon. They faced severe problems as everything got washed away. We have now proposed a `11 crore project to address the issue here. The erosion has been most severe at the river mouths, like Pavinkurve, where River Venkatapura joins the Arabian Sea and Thappalakere.

The menace is increasing in recent years, say officials and experts. Uttara Kannada district had remained unaffected for a long time. Erosion occurs during monsoon when sea levels increase. There is no erosion when beaches have sand deposits. Due to various reasons, these deposits have reduced drastically, including due to extraction of sand, construction of vented dams and other aspects, says Rathod.

ALSO READ|Disappearing beaches: Loss of a crucial buffer along coast hurting Kerala

He points out that encroachment on beaches is another reason for erosion, and happens mostly in Dakshina Kannada and Udupi, where people live near beaches.Shivakumar Haragi, Assistant Professor, Department of Marine Biology, Karnataka University, Dharwad, points out that changes in the rainfall pattern due to climate change, in turn due to global warming, is the major reason for erosion as the intensity of the rainfall is heavier. As a result, the sand does not deposit and the erosion increases.

Livelihoods affectedThe erosion has already affected the livelihoods of thousands of fishermen and is bound to worsen further. This year, during monsoon, hundreds of boats were washed away both in Kundapur and Bhatkal. This is what happens if the sea erosion becomes severe, says Haragi. He adds that over 20,000 fishermens families will be hit badly in Uttara Kannada as most of them here are traditional fishermen who anchor their boats and dump their nets, motors and fishing gear on the shores.

However the silver lining is that Uttara Kannada is not as densely populated as the other two coastal districts, Udupi and Dakshina Kannada. Sea erosion is a major threat to the people living along the coast of Udupi and Dakshina Kannada districts. Sea walls have been constructed in many places along the 95 km coastline of Udupi and Dakshina Kannada since the early 2000s. But the permanent measures are still to be put in place.

ALSO READ|Waves take awaybig slice of Tamil Naducoastline:Report

Some measures at workHalealive area in Koteshwara Gram Panchayat in Kundapur taluk of Udupi district, seashore residents have sought protection from sea incursion by constructing a permanent barrier. Despite our request, no steps have been taken and the shoreline is eroding every year, the locals say. The `300 crore funding by Asian Development Bank to construct sea walls has not yielded satisfactory results.

A study by the Department of Applied Mechanics and Hydraulics, National Institute of Technology Karnataka, Surathkal, Mangaluru, states that around 46 km of the total 95 km coastline in Udupi and Dakshina Kannada is in the critical erosion category. 59 per cent is at very high risk, 7 percent at high risk, 4 percent moderate and 30 percent vulnerable.

Karnataka State Minister for Fisheries, Ports and Inland Water Transport S Angara says that at some places like Uchila near Ullal of Dakshina Kannada district, sea wave breakers have been installed. This technology is suitable and can be used on an experimental basis in some places.

At Maravanthe in Udupi district, duck foot technology may be implemented on an experimental basis. Later based on the success rate, the two different technologies may be introduced in other parts, he said, examining suggestions from experts. The total financial implications of the two projects is yet to be known.

One estimate states that the sea wave breaker project costs `25 crore to cover 1 km of seashore. Angara says it has been implemented at Nellikunnu in Kasaragod, Kerala. UK Yoosuf, a Kasaragod businessman, has pitched the idea of introducing the technology. A project proposal has been submitted to Bommai, who has forwarded it to the Chief Secretary to check its feasibility.

ALSO READ|Uppada Beach Road closed due to high tides, coastal erosion

Though Prof Haragi suggests that green wall protection is the most suited to prevent erosion, the port department seems not optimistic. Haragi emphasises that proper planning and management will be helpful. We must identify vulnerable areas, manage them in consultation with locals and take long-term measures. The sea wall is highly unscientific.

There needs to be proper planning and advanced technology. We have to have a long-term planning of shoreline management (artificial green belt creation) and wherever immediate measures are taken, it should be done scientifically. Maravanthe is the best example of long-term planning and a permanent solution, he said.

Development in Western Ghats hit

The Western Ghatshas reduced the pace of development in the region which has marginally helpedto naturally preventsea erosion

Low populationdensity has checkedthe mega populationon the beaches of the west coast

The erosion is due to global warming,which has affected the rainfall pattern

Ports and break waters which are major players in preventing sea erosion are very limited in numbers, particularly in Uttara Kannada

Many ports, both fishing and commercial, are being planned under the Sagarmala project which hints that sea erosionis bound to increase in the future

See the article here:

Sea gnawing away at Karnataka beaches, coasts

Mesothelioma – Symptoms and causes – Mayo Clinic

Overview

Malignant mesothelioma (me-zoe-thee-lee-O-muh) is a type of cancer that occurs in the thin layer of tissue that covers the majority of your internal organs (mesothelium).

Mesothelioma is an aggressive and deadly form of cancer. Mesothelioma treatments are available, but for many people with mesothelioma, a cure isn't possible.

Doctors divide mesothelioma into different types based on what part of the mesothelium is affected. Mesothelioma most often affects the tissue that surrounds the lungs (pleura). This type is called pleural mesothelioma. Other, rarer types of mesothelioma affect tissue in the abdomen (peritoneal mesothelioma), around the heart and around the testicles.

Mesothelioma care at Mayo Clinic

Signs and symptoms of mesothelioma vary depending on where the cancer occurs.

Pleural mesothelioma, which affects the tissue that surrounds the lungs, causes signs and symptoms that may include:

Peritoneal mesothelioma, which occurs in tissue in the abdomen, causes signs and symptoms that may include:

Signs and symptoms of other types of mesothelioma are unclear, since these forms of the disease are very rare.

Pericardial mesothelioma, which affects tissue that surrounds the heart, can cause signs and symptoms such as breathing difficulty and chest pains.

Mesothelioma of tunica vaginalis, which affects tissue surrounding the testicles, may be first detected as swelling or a mass on a testicle.

See your doctor if you have signs and symptoms that worry you. Signs and symptoms of mesothelioma aren't specific to this disease and, due to the rarity of mesothelioma, are more likely to be related to other conditions. If any persistent signs and symptoms seem unusual or bothersome, ask your doctor to evaluate them. Tell your doctor if you've been exposed to asbestos.

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In general, cancer begins when a series of changes (mutations) happens in a cell's DNA. The DNA contains the instructions that tell a cell what to do. The mutations tell the cell to grow and multiply out of control. The abnormal cells accumulate and form a tumor.

It isn't clear what causes the initial genetic mutations that lead to mesothelioma, though researchers have identified factors that may increase the risk. It's likely that cancers form because of an interaction between many factors, such as inherited conditions, your environment, your health conditions and your lifestyle choices.

Most mesotheliomas are thought to be related to asbestos exposure. Asbestos is a mineral that's found naturally in the environment. Asbestos fibers are strong and resistant to heat, making them useful in a wide variety of applications, such as in insulation, brakes, shingles, flooring and many other products.

When asbestos is broken up, such as during the mining process or when removing asbestos insulation, dust may be created. If the dust is inhaled or swallowed, the asbestos fibers will settle in the lungs or in the stomach, where they can cause irritation that may lead to mesothelioma. Exactly how this happens isn't understood. It can take 20 to 60 years or more for mesothelioma to develop after asbestos exposure.

Most people with asbestos exposure never develop mesothelioma. This indicates that other factors may be involved in determining whether someone gets mesothelioma. For instance, you could inherit a predisposition to cancer or some other condition could increase your risk.

Factors that may increase the risk of mesothelioma include:

As pleural mesothelioma spreads in the chest, it puts pressure on the structures in that area. This can cause complications, such as:

Reducing your exposure to asbestos may lower your risk of mesothelioma.

Most people with mesothelioma were exposed to the asbestos fibers at work. Workers who may encounter asbestos fibers include:

Ask your employer whether you have a risk of asbestos exposure on the job.

Follow all safety precautions in your workplace, such as wearing protective equipment. You may also be required to shower and change out of your work clothes before taking a lunch break or going home. Talk to your doctor about other precautions you can take to protect yourself from asbestos exposure.

Older homes and buildings may contain asbestos. In many cases, it's more dangerous to remove the asbestos than it is to leave it intact. Breaking up asbestos may cause fibers to become airborne, where they can be inhaled. Consult experts trained to detect asbestos in your home. These experts may test the air in your home to determine whether the asbestos is a risk to your health. Don't attempt to remove asbestos from your home hire a qualified expert.

Oct. 11, 2022

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Mesothelioma - Symptoms and causes - Mayo Clinic

Mesothelioma Cancer | Causes, Diagnosis, Life Expectancy & Treatment

Common Tests for Diagnosing Mesothelioma

Before performing a tissue biopsy to diagnose mesothelioma, doctors may check for abnormalities. This process may involve various tests, like bloodwork and imaging scans.

Doctors often use imaging scans in the initial stages of a mesothelioma diagnosis. These tests commonly include CT scans, MRIs and X-rays. Scans, like a chest X-ray, can help doctors determine the extent and location of tumors. Doctors may also use imaging to see how far the disease has progressed.

Each scan has different benefits and limitations. Depending on each case, doctors may recommend more than one type of imaging scan. After a diagnosis, doctors may again use these tests to help determine the stage of the disease, monitor spread and check for any fluid buildup.

Biopsies are an important step in diagnosing and treating mesothelioma. A biopsy, which removes tissue or fluid for testing, is the only way to diagnose mesothelioma. Imaging scans and other tests can play a role in the diagnosis process, but only biopsy testing can be conclusive. A biopsy can also help determine important disease factors, like cell type.

A biopsy is often performed with a needle that extracts a fluid or tissue sample. After the procedure, a pathologist will analyze the sample. Some biopsy methods are less invasive than others.

Blood tests measure indicators of mesothelioma, called biomarkers, in a blood sample. Doctors may combine bloodwork with a biopsy to confirm a mesothelioma diagnosis. Blood tests alone cannot diagnose mesothelioma.

MESOMARK is a blood test that has approval for some mesothelioma monitoring. While other tests may identify general cancer indicators, MESOMARK is specific to mesothelioma indicators. Advances in blood test methods may someday support earlier mesothelioma diagnosis.

Staging is another important step in the initial diagnostic process. After confirming a mesothelioma diagnosis, doctors often go on to estimate its stage. The most common mesothelioma staging method is the tumor node metastasis (TNM) staging system. Stages range from early stages (1 and 2) to later stages (3 and 4).

More:

Mesothelioma Cancer | Causes, Diagnosis, Life Expectancy & Treatment

Mesothelioma – Wikipedia

Mesothelioma is a type of cancer that develops from the thin layer of tissue that covers many of the internal organs (known as the mesothelium).[9] The most common area affected is the lining of the lungs and chest wall.[1][3] Less commonly the lining of the abdomen and rarely the sac surrounding the heart,[10] or the sac surrounding the testis may be affected.[1][11] Signs and symptoms of mesothelioma may include shortness of breath due to fluid around the lung, a swollen abdomen, chest wall pain, cough, feeling tired, and weight loss.[1] These symptoms typically come on slowly.[2]

More than 80% of mesothelioma cases are caused by exposure to asbestos.[3] The greater the exposure the greater the risk.[3] As of 2013, about 125 million people worldwide have been exposed to asbestos at work.[12] High rates of disease occur in people who mine asbestos, produce products from asbestos, work with asbestos products, live with asbestos workers, or work in buildings containing asbestos.[3] Asbestos exposure and the onset of cancer are generally separated by about 40 years.[3] Washing the clothing of someone who worked with asbestos also increases the risk.[12] Other risk factors include genetics and infection with the simian virus 40.[3] The diagnosis may be suspected based on chest X-ray and CT scan findings, and is confirmed by either examining fluid produced by the cancer or by a tissue biopsy of the cancer.[2]

Prevention focuses on reducing exposure to asbestos.[4] Treatment often includes surgery, radiation therapy, and chemotherapy.[5] A procedure known as pleurodesis, which involves using substances such as talc to scar together the pleura, may be used to prevent more fluid from building up around the lungs.[5] Chemotherapy often includes the medications cisplatin and pemetrexed.[2] The percentage of people that survive five years following diagnosis is on average 8% in the United States.[6]

In 2015, about 60,800 people had mesothelioma, and 32,000 died from the disease.[7][8] Rates of mesothelioma vary in different areas of the world.[3] Rates are higher in Australia, the United Kingdom, and lower in Japan.[3] It occurs in about 3,000 people per year in the United States.[13] It occurs more often in males than females.[3] Rates of disease have increased since the 1950s.[3] Diagnosis typically occurs after the age of 65 and most deaths occur around 70 years old.[3] The disease was rare before the commercial use of asbestos.[3]

Symptoms or signs of mesothelioma may not appear until 20 to 50 years (or more) after exposure to asbestos. Shortness of breath, cough, and pain in the chest due to an accumulation of fluid in the pleural space (pleural effusion) are often symptoms of pleural mesothelioma.[14]

Mesothelioma that affects the pleura can cause these signs and symptoms:[14]

In severe cases, the person may have many tumor masses. The individual may develop a pneumothorax, or collapse of the lung. The disease may metastasize, or spread to other parts of the body.[citation needed]

The most common symptoms of peritoneal mesothelioma are abdominal swelling andpain due to ascites (a buildup of fluid in the abdominal cavity). Other features may include weight loss, fever, night sweats, poor appetite, vomiting, constipation, and umbilical hernia.[15] If the cancer has spread beyond the mesothelium to other parts of the body, symptoms may include pain, trouble swallowing, or swelling of the neck or face. These symptoms may be caused by mesothelioma or by other, less serious conditions.[citation needed]

Tumors that affect the abdominal cavity often do not cause symptoms until they are at a late stage. Symptoms include:[citation needed]

Pericardial mesothelioma is not well characterized, but observed cases have included cardiac symptoms, specifically constrictive pericarditis, heart failure, pulmonary embolism, and cardiac tamponade. They have also included nonspecific symptoms, including substernal chest pain, orthopnea (shortness of breath when lying flat), and cough. These symptoms are caused by the tumor encasing or infiltrating the heart.[10]

In severe cases of the disease, the following signs and symptoms may be present:[7]

If a mesothelioma forms metastases, these most commonly involve the liver, adrenal gland, kidney, or other lung.[16]

Working with asbestos is the most common risk factor for mesothelioma.[17] However, mesothelioma has been reported in some individuals without any known exposure to asbestos. Tentative evidence also raises concern about carbon nanotubes.[18][19]

The incidence of mesothelioma has been found to be higher in populations living near naturally occurring asbestos. People can be exposed to naturally occurring asbestos in areas where mining or road construction is occurring, or when the asbestos-containing rock is naturally weathered. Another common route of exposure is through asbestos-containing soil, which is used to whitewash, plaster, and roof houses in Greece.[12] In central Cappadocia, Turkey, mesothelioma was causing 50% of all deaths in three small villagesTuzky, Karain, and Sarhdr. Initially, this was attributed to erionite. Environmental exposure to asbestos has caused mesothelioma in places other than Turkey, including Corsica, Greece, Cyprus, China, and California.[12][20][21] In the northern Greek mountain town of Metsovo, this exposure had resulted in mesothelioma incidence around 300 times more than expected in asbestos-free populations, and was associated with very frequent pleural calcification known as Metsovo lung.[22][23]

The documented presence of asbestos fibers in water supplies and food products has fostered concerns about the possible impact of long-term and, as yet, unknown exposure of the general population to these fibers.[24]

Exposure to talc is also a risk factor for mesothelioma; exposure can affect those who live near talc mines, work in talc mines, or work in talc mills.[25]

In the United States, asbestos is considered the major cause of malignant mesothelioma[26] and has been considered "indisputably"[27] associated with the development of mesothelioma. Indeed, the relationship between asbestos and mesothelioma is so strong that many consider mesothelioma a "signal" or "sentinel" tumor.[28][29][30][31] A history of asbestos exposure exists in most cases.

Pericardial mesothelioma may not be associated with asbestos exposure.[10]

Asbestos was known in antiquity, but it was not mined and widely used commercially until the late 19th century. The dangers were not unknown in antiquity. Pliny the Elder, a Roman author and naturalist, observed that quarry slaves from asbestos mines tended to die young.[32] Its use greatly increased during World War II. Since the early 1940s, millions of American workers have been exposed to asbestos dust. Initially, the risks associated with asbestos exposure were not publicly known. However, an increased risk of developing mesothelioma was later found among naval personnel (e.g., Navy, Marine Corps, and Coast Guard), shipyard workers, people who work in asbestos mines and mills, producers of asbestos products, workers in the heating and construction industries, and other tradespeople. Today, the official position of the U.S. Occupational Safety and Health Administration (OSHA) and the U.S. EPA is that protections and "permissible exposure limits" required by U.S. regulations, while adequate to prevent most asbestos-related non-malignant disease, are not adequate to prevent or protect against asbestos-related cancers such as mesothelioma.[33] Likewise, the British Government's Health and Safety Executive (HSE) states formally that any threshold for exposure to asbestos must be at a very low level and it is widely agreed that if any such threshold does exist at all, then it cannot currently be quantified. For practical purposes, therefore, HSE assumes that no such "safe" threshold exists. Others have noted as well that there is no evidence of a threshold level below which there is no risk of mesothelioma.[34] There appears to be a linear, doseresponse relationship, with increasing dose producing increasing risk of disease.[35] Nevertheless, mesothelioma may be related to brief, low level or indirect exposures to asbestos.[27] The dose necessary for effect appears to be lower for asbestos-induced mesothelioma than for pulmonary asbestosis or lung cancer.[27] Again, there is no known safe level of exposure to asbestos as it relates to increased risk of mesothelioma.

The time from first exposure to onset of the disease, is between 25 and 70 years.[36] It is virtually never less than fifteen years and peaks at 3040 years.[27][37] The duration of exposure to asbestos causing mesothelioma can be short. For example, cases of mesothelioma have been documented with only 13 months of exposure.[38][39]

Exposure to asbestos fibers has been recognized as an occupational health hazard since the early 20th century. Numerous epidemiological studies have associated occupational exposure to asbestos with the development of pleural plaques, diffuse pleural thickening, asbestosis, carcinoma of the lung and larynx, gastrointestinal tumors, and diffuse malignant mesothelioma of the pleura and peritoneum. Asbestos has been widely used in many industrial products, including cement, brake linings, gaskets, roof shingles, flooring products, textiles, and insulation.[40]

Commercial asbestos mining at Wittenoom, Western Australia, took place from 1937 to 1966. The first case of mesothelioma in the town occurred in 1960. The second case was in 1969, and new cases began to appear more frequently thereafter. The lag time between initial exposure to asbestos and the development of mesothelioma varied from 12 years 9 months up to 58 years.[41] A cohort study of miners employed at the mine reported that 85 deaths attributable to mesothelioma had occurred by 1985. By 1994, 539 reported deaths due to mesothelioma had been reported in Western Australia.[citation needed]

Occupational exposure to asbestos in the United States mainly occurs when people are maintaining buildings that already have asbestos. Approximately 1.3 million US workers are exposed to asbestos annually; in 2002, an estimated 44,000 miners were potentially exposed to asbestos.[25]

Family members and others living with asbestos workers have an increased risk of developing mesothelioma, and possibly other asbestos-related diseases.[11][42][43] This risk may be the result of exposure to asbestos dust brought home on the clothing and hair of asbestos workers via washing a worker's clothes or coming into contact with asbestos-contaminated work clothing.[12][25] To reduce the chance of exposing family members to asbestos fibres, asbestos workers are usually required to shower and change their clothing before leaving the workplace.[citation needed]

Many building materials used in both public and domestic premises prior to the banning of asbestos may contain asbestos. Those performing renovation works or DIY activities may expose themselves to asbestos dust. In the UK, use of chrysotile asbestos was banned at the end of 1999. Brown and blue asbestos were banned in the UK around 1985. Buildings built or renovated prior to these dates may contain asbestos materials.[44]

Therefore, it is a legal requirement that all who may come across asbestos in their day-to-day work have been provided with the relevant asbestos training.

In a recent research carried on white American population in 2012, it was found that people with a germline mutation in their BAP1 gene are at higher risk of developing mesothelioma and uveal melanoma.[45]

Erionite is a zeolite mineral with similar properties to asbestos and is known to cause mesothelioma.[11] Detailed epidemiological investigation has shown that erionite causes mesothelioma mostly in families with a genetic predisposition.[12][20][21] Erionite is found in deposits in the Western United States, where it is used in gravel for road surfacing, and in Turkey, where it is used to construct homes. In Turkey, the United States, and Mexico, erionite has been associated with mesothelioma and has thus been designated a "known human carcinogen" by the US National Toxicology Program.[21]

In rare cases, mesothelioma has also been associated with irradiation of the chest or abdomen, intrapleural thorium dioxide (thorotrast) as a contrast medium, and inhalation of other fibrous silicates, such as erionite or talc.[11][25] Some studies suggest that simian virus 40 (SV40) may act as a cofactor in the development of mesothelioma.[25] This has been confirmed in animal studies,[46][47] but studies in humans are inconclusive.[46][48][49]

The mesothelium consists of a single layer of flattened to cuboidal cells forming the epithelial lining of the serous cavities of the body including the peritoneal, pericardial and pleural cavities. Deposition of asbestos fibers in the parenchyma of the lung may result in the penetration of the visceral pleura from where the fiber can then be carried to the pleural surface, thus leading to the development of malignant mesothelial plaques. The processes leading to the development of peritoneal mesothelioma remain unresolved, although it has been proposed that asbestos fibers from the lung are transported to the abdomen and associated organs via the lymphatic system. Additionally, asbestos fibers may be deposited in the gut after ingestion of sputum contaminated with asbestos fibers.[citation needed]

Pleural contamination with asbestos or other mineral fibers has been shown to cause cancer. Long thin asbestos fibers (blue asbestos, amphibole fibers) are more potent carcinogens than "feathery fibers" (chrysotile or white asbestos fibers).[27] However, there is now evidence that smaller particles may be more dangerous than the larger fibers. They remain suspended in the air where they can be inhaled, and may penetrate more easily and deeper into the lungs. "We probably will find out a lot more about the health aspects of asbestos from [the World Trade Center attack], unfortunately," said Dr. Alan Fein, chief of pulmonary and critical-care medicine at North Shore-Long Island Jewish Health System.[50]

Mesothelioma development in rats has been demonstrated following intra-pleural inoculation of phosphorylated chrysotile fibers. It has been suggested that in humans, transport of fibers to the pleura is critical to the pathogenesis of mesothelioma. This is supported by the observed recruitment of significant numbers of macrophages and other cells of the immune system to localized lesions of accumulated asbestos fibers in the pleural and peritoneal cavities of rats. These lesions continued to attract and accumulate macrophages as the disease progressed, and cellular changes within the lesion culminated in a morphologically malignant tumor.[citation needed]

Experimental evidence suggests that asbestos acts as a complete carcinogen with the development of mesothelioma occurring in sequential stages of initiation and promotion. The molecular mechanisms underlying the malignant transformation of normal mesothelial cells by asbestos fibers remain unclear despite the demonstration of its oncogenic capabilities (see next-but-one paragraph). However, complete in vitro transformation of normal human mesothelial cells to a malignant phenotype following exposure to asbestos fibers has not yet been achieved. In general, asbestos fibers are thought to act through direct physical interactions with the cells of the mesothelium in conjunction with indirect effects following interaction with inflammatory cells such as macrophages.[citation needed]

Analysis of the interactions between asbestos fibers and DNA has shown that phagocytosed fibers are able to make contact with chromosomes, often adhering to the chromatin fibers or becoming entangled within the chromosome.[51] This contact between the asbestos fiber and the chromosomes or structural proteins of the spindle apparatus can induce complex abnormalities. The most common abnormality is monosomy of chromosome 22. Other frequent abnormalities include structural rearrangement of 1p, 3p, 9p and 6q chromosome arms.[citation needed]

Common gene abnormalities in mesothelioma cell lines include deletion of the tumor suppressor genes:[citation needed]

Asbestos has also been shown to mediate the entry of foreign DNA into target cells. Incorporation of this foreign DNA may lead to mutations and oncogenesis by several possible mechanisms:[citation needed]

Several genes are commonly mutated in mesothelioma, and may be prognostic factors. These include epidermal growth factor receptor (EGFR) and C-Met, receptor tyrosine kinases which are overexpressed in many mesotheliomas. Some association has been found with EGFR and epithelioid histology but no clear association has been found between EGFR overexpression and overall survival. Expression of AXL receptor tyrosine kinase is a negative prognostic factor. Expression of PDGFRB is a positive prognostic factor.[60] In general, mesothelioma is characterized by loss of function in tumor suppressor genes, rather than by an overexpression or gain of function in oncogenes.[61]

As an environmentally triggered malignancy, mesothelioma tumors have been found to be polyclonal in origin, by performing an X-inactivation based assay on epitheloid and biphasic tumors obtained from female patients.[62] These results suggest that an environmental factor, most likely asbestos exposure, may damage and transform a group of cells in the tissue, resulting in a population of tumor cells that are, albeit only slightly, genetically different.[63]

Asbestos fibers have been shown to alter the function and secretory properties of macrophages, ultimately creating conditions which favour the development of mesothelioma. Following asbestos phagocytosis, macrophages generate increased amounts of hydroxyl radicals, which are normal by-products of cellular anaerobic metabolism. However, these free radicals are also known clastogenic (chromosome-breaking)and membrane-active agents thought to promote asbestos carcinogenicity. These oxidants can participate in the oncogenic process by directly and indirectly interacting with DNA, modifying membrane-associated cellular events, including oncogene activation and perturbation of cellular antioxidant defences.[citation needed]

Asbestos also may possess immunosuppressive properties. For example, chrysotile fibres have been shown to depress the in vitro proliferation of phytohemagglutinin-stimulated peripheral blood lymphocytes, suppress natural killer cell lysis and significantly reduce lymphokine-activated killer cell viability and recovery. Furthermore, genetic alterations in asbestos-activated macrophages may result in the release of potent mesothelial cell mitogens such as platelet-derived growth factor (PDGF) and transforming growth factor- (TGF-) which in turn, may induce the chronic stimulation and proliferation of mesothelial cells after injury by asbestos fibres.[citation needed]

Diagnosis of mesothelioma can be suspected with imaging but is confirmed with biopsy. It must be clinically and histologically differentiated from other pleural and pulmonary malignancies, including reactive pleural disease, primary lung carcinoma, pleural metastases of other cancers, and other primary pleural cancers.[11]Primary pericardial mesothelioma is often diagnosed after it has metastasized to lymph nodes or the lungs.[10]

Diagnosing mesothelioma is often difficult because the symptoms are similar to those of a number of other conditions. Diagnosis begins with a review of the patient's medical history. A history of exposure to asbestos may increase clinical suspicion for mesothelioma. A physical examination is performed, followed by chest X-ray and often lung function tests. The X-ray may reveal pleural thickening commonly seen after asbestos exposure and increases suspicion of mesothelioma.[14] A CT (or CAT) scan or an MRI is usually performed. If a large amount of fluid is present, abnormal cells may be detected by cytopathology if this fluid is aspirated with a syringe.[10] For pleural fluid, this is done by thoracentesis or tube thoracostomy (chest tube); for ascites, with paracentesis or ascitic drain; and for pericardial effusion with pericardiocentesis. While absence of malignant cells on cytology does not completely exclude mesothelioma, it makes it much more unlikely, especially if an alternative diagnosis can be made (e.g., tuberculosis, heart failure).[citation needed] However, with primary pericardial mesothelioma, pericardial fluid may not contain malignant cells and a tissue biopsy is more useful in diagnosis.[10] Using conventional cytology diagnosis of malignant mesothelioma is difficult, but immunohistochemistry has greatly enhanced the accuracy of cytology.[citation needed]

Generally, a biopsy is needed to confirm a diagnosis of malignant mesothelioma. A doctor removes a sample of tissue for examination under a microscope by a pathologist. A biopsy may be done in different ways, depending on where the abnormal area is located. If the cancer is in the chest, the doctor may perform a thoracoscopy. In this procedure, the doctor makes a small cut through the chest wall and puts a thin, lighted tube called a thoracoscope into the chest between two ribs. Thoracoscopy allows the doctor to look inside the chest and obtain tissue samples. Alternatively, the cardiothoracic surgeon might directly open the chest (thoracotomy). If the cancer is in the abdomen, the doctor may perform a laparoscopy. To obtain tissue for examination, the doctor makes a small incision in the abdomen and inserts a special instrument into the abdominal cavity. If these procedures do not yield enough tissue, an open surgical procedure may be necessary.[citation needed]

Immunohistochemical studies play an important role for the pathologist in differentiating malignant mesothelioma from neoplastic mimics, such as breast or lung cancer that has metastasized to the pleura. There are numerous tests and panels available, but no single test is perfect for distinguishing mesothelioma from carcinoma or even benign versus malignant. The positive markers indicate that mesothelioma is present; if other markers are positive it may indicate another type of cancer, such as breast or lung adenocarcinoma. Calretinin is a particularly important marker in distinguishing mesothelioma from metastatic breast or lung cancer.[11]

There are three main histological subtypes of malignant mesothelioma: epithelioid, sarcomatous, and biphasic. Epithelioid and biphasic mesothelioma make up approximately 75-95% of mesotheliomas and have been well characterized histologically, whereas sarcomatous mesothelioma has not been studied extensively. Most mesotheliomas express high levels of cytokeratin 5 regardless of subtype.[11]

Epithelioid mesothelioma is characterized by high levels of calretinin.[11]

Sarcomatous mesothelioma does not express high levels of calretinin.[11]

Other morphological subtypes have been described:

Staging of mesothelioma is based on the recommendation by the International Mesothelioma Interest Group.[64] TNM classification of the primary tumor, lymph node involvement, and distant metastasis is performed. Mesothelioma is staged IaIV (one-A to four) based on the TNM status.[64][65]

Mesothelioma can be prevented in most cases by preventing exposure to asbestos. The US National Institute for Occupational Safety and Health maintains a recommended exposure limit of 0.1 asbestos fiber per cubic centimeter.[25]

There is no universally agreed protocol for screening people who have been exposed to asbestos. Screening tests might diagnose mesothelioma earlier than conventional methods thus improving the survival prospects for patients. The serum osteopontin level might be useful in screening asbestos-exposed people for mesothelioma. The level of soluble mesothelin-related protein is elevated in the serum of about 75% of patients at diagnosis and it has been suggested that it may be useful for screening.[66] Doctors have begun testing the Mesomark assay, which measures levels of soluble mesothelin-related proteins (SMRPs) released by mesothelioma cells.[67]

Mesothelioma is generally resistant to radiation and chemotherapy treatment.[68] Long-term survival and cures are exceedingly rare.[11] Treatment of malignant mesothelioma at earlier stages has a better prognosis. Clinical behavior of the malignancy is affected by several factors including the continuous mesothelial surface of the pleural cavity which favors local metastasis via exfoliated cells, invasion to underlying tissue and other organs within the pleural cavity, and the extremely long latency period between asbestos exposure and development of the disease. The histological subtype and the patient's age and health status also help predict prognosis. The epithelioid histology responds better to treatment and has a survival advantage over sarcomatoid histology.[69]

The effectiveness of radiotherapy compared to chemotherapy or surgery for malignant pleural mesothelioma is not known.[70]

Surgery, by itself, has proved disappointing. In one large series, the median survival with surgery (including extrapleural pneumonectomy) was only 11.7 months.[71] However, research indicates varied success when used in combination with radiation and chemotherapy (Duke, 2008), or with one of the latter. A pleurectomy/decortication is the most common surgery, in which the lining of the chest is removed. Less common is an extrapleural pneumonectomy (EPP), in which the lung, lining of the inside of the chest, the hemi-diaphragm and the pericardium are removed.[citation needed] In localized pericardial mesothelioma, pericardectomy can be curative; when the tumor has metastasized, pericardectomy is a palliative care option. It is often not possible to remove the entire tumor.[10]

For patients with localized disease, and who can tolerate a radical surgery, radiation can be given post-operatively as a consolidative treatment. The entire hemithorax is treated with radiation therapy, often given simultaneously with chemotherapy. Delivering radiation and chemotherapy after a radical surgery has led to extended life expectancy in selected patient populations. It can also induce severe side-effects, including fatal pneumonitis.[72] As part of a curative approach to mesothelioma, radiotherapy is commonly applied to the sites of chest drain insertion, in order to prevent growth of the tumor along the track in the chest wall.[citation needed]

Although mesothelioma is generally resistant to curative treatment with radiotherapy alone, palliative treatment regimens are sometimes used to relieve symptoms arising from tumor growth, such as obstruction of a major blood vessel. Radiation therapy, when given alone with curative intent, has never been shown to improve survival from mesothelioma. The necessary radiation dose to treat mesothelioma that has not been surgically removed would be beyond human tolerance.[citation needed] Radiotherapy is of some use in pericardial mesothelioma.[10]

Chemotherapy is the only treatment for mesothelioma that has been proven to improve survival in randomised and controlled trials. The landmark study published in 2003 by Vogelzang and colleagues compared cisplatin chemotherapy alone with a combination of cisplatin and pemetrexed (brand name Alimta) chemotherapy in patients who had not received chemotherapy for malignant pleural mesothelioma previously and were not candidates for more aggressive "curative" surgery.[73] This trial was the first to report a survival advantage from chemotherapy in malignant pleural mesothelioma, showing a statistically significant improvement in median survival from 10 months in the patients treated with cisplatin alone to 13.3 months in the group of patients treated with cisplatin in the combination with pemetrexed and who also received supplementation with folate and vitamin B12. Vitamin supplementation was given to most patients in the trial and pemetrexed related side effects were significantly less in patients receiving pemetrexed when they also received daily oral folate 500mcg and intramuscular vitamin B12 1000mcg every 9 weeks compared with patients receiving pemetrexed without vitamin supplementation. The objective response rate increased from 20% in the cisplatin group to 46% in the combination pemetrexed group. Some side effects such as nausea and vomiting, stomatitis, and diarrhoea were more common in the combination pemetrexed group but only affected a minority of patients and overall the combination of pemetrexed and cisplatin was well tolerated when patients received vitamin supplementation; both quality of life and lung function tests improved in the combination pemetrexed group. In February 2004, the United States Food and Drug Administration (FDA) approved pemetrexed for treatment of malignant pleural mesothelioma.[74] However, there are still unanswered questions about the optimal use of chemotherapy, including when to start treatment, and the optimal number of cycles to give.[citation needed] Cisplatin and pemetrexed together give patients a median survival of 12.1 months.[11]

Cisplatin in combination with raltitrexed has shown an improvement in survival similar to that reported for pemetrexed in combination with cisplatin, but raltitrexed is no longer commercially available for this indication. For patients unable to tolerate pemetrexed, cisplatin in combination with gemcitabine or vinorelbine is an alternative, or vinorelbine on its own, although a survival benefit has not been shown for these drugs. For patients in whom cisplatin cannot be used, carboplatin can be substituted but non-randomised data have shown lower response rates and high rates of haematological toxicity for carboplatin-based combinations, albeit with similar survival figures to patients receiving cisplatin.[75] Cisplatin in combination with premetrexed disodium, folic acid, and vitamin B12 may also improve survival for people who are responding to chemotherapy.[76]

In January 2009, the United States FDA approved using conventional therapies such as surgery in combination with radiation and or chemotherapy on stage I or II Mesothelioma after research conducted by a nationwide study by Duke University concluded an almost 50 point increase in remission rates.[citation needed]

In pericardial mesothelioma, chemotherapy typically adriamycin or cisplatin is primarily used to shrink the tumor and is not curative.[10]

Treatment regimens involving immunotherapy have yielded variable results. For example, intrapleural inoculation of Bacillus Calmette-Gurin (BCG) in an attempt to boost the immune response, was found to be of no benefit to the patient (while it may benefit patients with bladder cancer). Mesothelioma cells proved susceptible to in vitro lysis by LAK cells following activation by interleukin-2 (IL-2), but patients undergoing this particular therapy experienced major side effects. Indeed, this trial was suspended in view of the unacceptably high levels of IL-2 toxicity and the severity of side effects such as fever and cachexia. Nonetheless, other trials involving interferon alpha have proved more encouraging with 20% of patients experiencing a greater than 50% reduction in tumor mass combined with minimal side effects.[citation needed]

In October 2020, the FDA approved the combination of nivolumab (Opdivo) with ipilimumab (Yervoy) for the first-line treatment of adults with malignant pleural mesothelioma (MPM) that cannot be removed by surgery.[74] Nivolumab and ipilimumab are both monoclonal antibodies that, when combined, decrease tumor growth by enhancing T-cell function.[74] The combination therapy was evaluated through a randomized, open-label trial in which participants who received nivolumab in combination with ipilimumab survived a median of 18.1 months while participants who underwent chemotherapy survived a median of 14.1 months.[74]

Hyperthermic intrathoracic chemotherapy is used in conjunction with surgery,[77] including in patients with malignant pleural mesothelioma.[78] The surgeon removes as much of the tumor as possible followed by the direct administration of a chemotherapy agent, heated to between 40 and 48C, in the abdomen. The fluid is perfused for 60 to 120 minutes and then drained. High concentrations of selected drugs are then administered into the pleural cavity. Heating the chemotherapy treatment increases the penetration of the drugs into tissues. Also, heating itself damages the malignant cells more than the normal cells.[citation needed]

Multimodal therapy, which includes a combined approach of surgery, radiation or photodynamic therapy, and chemotherapy, is not suggested for routine practice for treating malignant pleural mesothelioma.[79] The effectiveness and safety of multimodal therapy is not clear (not enough research has been performed) and one clinical trial has suggested a possible increased risk of adverse effects.[79]

Large series of examining multimodality treatment have only demonstrated modest improvement in survival (median survival 14.5 months and only 29.6% surviving 2 years).[71] Reducing the bulk of the tumor with cytoreductive surgery is key to extending survival. Two surgeries have been developed: extrapleural pneumonectomy and pleurectomy/decortication. The indications for performing these operations are unique. The choice of operation namely depends on the size of the patient's tumor. This is an important consideration because tumor volume has been identified as a prognostic factor in mesothelioma.[80] Pleurectomy/decortication spares the underlying lung and is performed in patients with early stage disease when the intention is to remove all gross visible tumor (macroscopic complete resection), not simply palliation.[81] Extrapleural pneumonectomy is a more extensive operation that involves resection of the parietal and visceral pleurae, underlying lung, ipsilateral (same side) diaphragm, and ipsilateral pericardium. This operation is indicated for a subset of patients with more advanced tumors, who can tolerate a pneumonectomy.[82]

Mesothelioma usually has a poor prognosis. Typical survival despite surgery is between 12 and 21 months depending on the stage of disease at diagnosis with about 7.5% of people surviving for 5 years.[83]

Women, young people, people with low-stage cancers, and people with epithelioid cancers have better prognoses.[11] Negative prognostic factors include sarcomatoid or biphasic histology, high platelet counts (above 400,000), age over 50 years, white blood cell counts above 15.5, low glucose levels in the pleural fluid, low albumin levels, and high fibrinogen levels. Several markers are under investigation as prognostic factors, including nuclear grade, and serum c-reactive protein. Long-term survival is rare.[60]

Pericardial mesothelioma has a 10-month median survival time.[10]

In peritoneal mesothelioma, high expression of WT-1 protein indicates a worse prognosis.[11]

Although reported incidence rates have increased in the past 20 years, mesothelioma is still a relatively rare cancer. The incidence rate varies from one country to another, from a low rate of less than 1 per 1,000,000 in Tunisia and Morocco, to the highest rate in Britain, Australia and Belgium: 30 per 1,000,000 per year.[84] For comparison, populations with high levels of smoking can have a lung cancer incidence of over 1,000 per 1,000,000. Incidence of malignant mesothelioma currently ranges from about 7 to 40 per 1,000,000 in industrialized Western nations, depending on the amount of asbestos exposure of the populations during the past several decades.[85] Worldwide incidence is estimated at 1-6 per 1,000,000.[11] Incidence of mesothelioma lags behind that of asbestosis due to the longer time it takes to develop; due to the cessation of asbestos use in developed countries, mesothelioma incidence is expected to decrease.[25] Incidence is expected to continue increasing in developing countries due to continuing use of asbestos.[11] Mesothelioma occurs more often in men than in women and risk increases with age, but this disease can appear in either men or women at any age. Approximately one fifth to one third of all mesotheliomas are peritoneal.[citation needed] Less than 5% of mesotheliomas are pericardial. The prevalence of pericardial mesothelioma is less than 0.002%; it is more common in men than women. It typically occurs in a person's 50s-70s.[10][86]

Between 1940 and 1979, approximately 27.5 million people were occupationally exposed to asbestos in the United States.[87] Between 1973 and 1984, the incidence of pleural mesothelioma among Caucasian males increased 300%. From 1980 to the late 1990s, the death rate from mesothelioma in the USA increased from 2,000 per year to 3,000, with men four times more likely to acquire it than women.[citation needed] More than 80% of mesotheliomas are caused by asbestos exposure.[11]

The incidence of peritoneal mesothelioma is 0.53.0 per million per year in men, and 0.22.0 per million per year in women.[88]

Mesothelioma accounts for less than 1% of all cancers diagnosed in the UK, (around 2,600 people were diagnosed with the disease in 2011), and it is the seventeenth most common cause of cancer death (around 2,400 people died in 2012).[89]

The connection between asbestos exposure and mesothelioma was discovered in the 1970s. In the United States, asbestos manufacture stopped in 2002. Asbestos exposure thus shifted from workers in asbestos textile mills, friction product manufacturing, cement pipe fabrication, and insulation manufacture and installation to maintenance workers in asbestos-containing buildings.[25]

Mesothelioma, though rare, has had a number of notable patients:

Although life expectancy with this disease is typically limited, there are notable survivors. In July 1982, Stephen Jay Gould, a well-regarded paleontologist, was diagnosed with peritoneal mesothelioma. After his diagnosis, Gould wrote "The Median Isn't the Message",[98] in which he argued that statistics such as median survival are useful abstractions, not destiny. Gould lived for another 20 years, eventually succumbing to cancer not linked to his mesothelioma.

Some people who were exposed to asbestos have collected damages for an asbestos-related disease, including mesothelioma. Compensation via asbestos funds or class action lawsuits is an important issue in law practices regarding mesothelioma.[citation needed]

The first lawsuits against asbestos manufacturers were in 1929. Since then, many lawsuits have been filed against asbestos manufacturers and employers, for neglecting to implement safety measures after the links between asbestos, asbestosis, and mesothelioma became known (some reports seem to place this as early as 1898). The liability resulting from the sheer number of lawsuits and people affected has reached billions of dollars.[99] The amounts and method of allocating compensation have been the source of many court cases, reaching up to the United States Supreme Court, and government attempts at resolution of existing and future cases. However, to date, the US Congress has not stepped in and there are no federal laws governing asbestos compensation.[100]In 2013, the "Furthering Asbestos Claim Transparency (FACT) Act of 2013" passed the US House of representatives and was sent to the US Senate, where it was referred to the Senate Judiciary Committee.[101] As the Senate did not vote on it before the end of the 113th Congress, it died in committee. It was revived in the 114th Congress, where it has not yet been brought before the House for a vote.[102][needs update]

The first lawsuit against asbestos manufacturers was brought in 1929. The parties settled that lawsuit, and as part of the agreement, the attorneys agreed not to pursue further cases. In 1960, an article published by Wagner et al. was seminal in establishing mesothelioma as a disease arising from exposure to asbestos.[103] The article referred to over 30 case studies of people who had had mesothelioma in South Africa. Some exposures were transient and some were mine workers. Before the use of advanced microscopy techniques, malignant mesothelioma was often diagnosed as a variant form of lung cancer.[104] In 1962, McNulty reported the first diagnosed case of malignant mesothelioma in an Australian asbestos worker.[105] The worker had worked in the mill at the asbestos mine in Wittenoom from 1948 to 1950.[citation needed]

In the town of Wittenoom, asbestos-containing mine waste was used to cover schoolyards and playgrounds. In 1965, an article in the British Journal of Industrial Medicine established that people who lived in the neighbourhoods of asbestos factories and mines, but did not work in them, had contracted mesothelioma.[citation needed]

Despite proof that the dust associated with asbestos mining and milling causes asbestos-related disease, mining began at Wittenoom in 1943 and continued until 1966. In 1974, the first public warnings of the dangers of blue asbestos were published in a cover story called "Is this Killer in Your Home?" in Australia's Bulletin magazine. In 1978, the Western Australian Government decided to phase out the town of Wittenoom, following the publication of a Health Dept. booklet, "The Health Hazard at Wittenoom", containing the results of air sampling and an appraisal of worldwide medical information.[citation needed]

By 1979, the first writs for negligence related to Wittenoom were issued against CSR and its subsidiary ABA, and the Asbestos Diseases Society was formed to represent the Wittenoom victims.[citation needed]

In Leeds, England the Armley asbestos disaster involved several court cases against Turner & Newall where local residents who contracted mesothelioma demanded compensation because of the asbestos pollution from the company's factory. One notable case was that of June Hancock, who contracted the disease in 1993 and died in 1997.[106]

The WT-1 protein is overexpressed in mesothelioma and is being researched as a potential target for drugs.[11]

There are two high-confidence miRNAs that can potentially serve as biomarkers of asbestos exposure and malignant mesothelioma. Validation studies are needed to assess their relevance.[citation needed]

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Mesothelioma - Wikipedia

Mesothelioma Cancer: Symptoms, Life Expectancy, Risk Factors … – asbestos

Key Facts About Mesothelioma

Mesothelioma is a type of cancer that develops in the mesothelium, a layer of protective tissue that covers the majority of internal organs.

Treatments are available to extend life expectancy and improve quality of life, but there is no cure for mesothelioma.

Tumor location determines the four types of mesothelioma.

Forms on the membrane or soft tissue lining, called the pleura, that covers the lungs. Accounts for the majority of all mesothelioma cases.

Forms on the tunica vaginalis or membrane that covers the testes. The rarest type of mesothelioma, representing less than 1% of cases.

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Asbestos causes mesothelioma. The carcinogen is the primary proven cause of the disease. Asbestos-related diseases may occur after repeated use of asbestos-contaminated products, such as talc and older construction materials.

This cancer begins to develop when a person inhales or swallows asbestos fibers. The fibers become lodged in the soft lining of the lungs, abdomen or heart. Over time, tumors form on the damaged tissue, leading to mesothelioma.

Most people exposed to asbestos will not develop mesothelioma. However, some factors place specific people more at risk than others.

Mesothelioma tumors develop in the lining of the lungs, abdomen or heart.

People who handled or were around asbestos for prolonged periods of time have the highest risk of developing mesothelioma. Those in close contact with exposed workers are also at risk.

Workers in construction jobs, firefighters and auto mechanics are among the top high-risk jobs.

Service people were exposed to high levels of asbestos because it was used in all military branches.

Women, children and other household members exposed to asbestos fibers on a workers clothing, hair or skin.

Symptoms of mesothelioma include dry cough, shortness of breath and respiratory complications. Other symptoms, which typically vary by type of mesothelioma, appear when tumors spread, grow and press against the chest wall and the abdominal cavity.

Talking to a doctor about your symptoms can lead to an early mesothelioma diagnosis, allowing for more treatment options. Mesothelioma symptoms appear like other, more common cancers and illnesses, and misdiagnosis is common. Its essential to be aware of your history of asbestos exposure and discuss it with your doctor as soon as possible.

Doctors use several procedures and tests to diagnose mesothelioma, but only a biopsy can confirm a mesothelioma diagnosis. A mesothelioma diagnosis in the early stages of cancer improves a patients eligibility for more treatment options.

Patients can expect to undergo several imaging scans, blood tests and biopsy procedures after their mesothelioma diagnosis. These tests help doctors confirm a mesothelioma diagnosis and determine cancer location, stage and cell type.

Most people initially undergo a basic chest X-ray to check for any abnormalities. If an abnormal growth or fluid around the lung is detected, doctors will recommend a more detailed imaging scan such as a PET scan, CT scan or MRI.

If cancer is suspected, doctors will recommend taking a sample of tissue, which is also known as a biopsy. Doctors use this tissue sample to definitively confirm the presence of malignant mesothelioma cells.

Blood tests may be used but do not confirm the presence of mesothelioma. Researchers are evaluating if blood tests can aid in the early diagnosis of at-risk former asbestos workers.

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The three cell types of mesothelioma are epithelioid, sarcomatoid and biphasic. They are named for the characteristics of cells within tumors. Epithelioid is the most common and responds well to many treatments. Sarcomatoid and biphasic are rarer and more resistant to therapies.

These cells are the most responsive to treatment. This type of mesothelioma accounts for 70% of mesothelioma diagnoses. It also leads to improved prognosis and life expectancy.

Cells of this type are least responsive to treatment. Patients with these cell types have poorer diagnoses and shorter life expectancies. This mesothelioma type accounts for 10% of all cases.

This is a combination of epithelioid and sarcomatoid cells. Its less responsive to treatment. Prognosis and life expectancy depend on the ratio of both cell types. It accounts for 30% to 40% of cases.

Staging tracks malignant mesothelioma tumor growth and helps doctors make treatment plans and predict patient prognoses. The stages of mesothelioma range from 1 to 4 and are based on tumor size and location.

Early-stage mesothelioma is more confined to one site, while late-stage mesothelioma shows tumors spreading beyond the chest or abdominal cavity. Staging is an integral part of determining treatment.

The four stages of mesothelioma are used to determine cancer progression and available treatment options.

Tumors have spread from the original location into adjacent structures, and the median life expectancy is 20 months.

Cancer has spread into regional lymph nodes, and the median life expectancy is 17.9 months.

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The standard treatment for mesothelioma may include surgery, chemotherapy, radiation or multimodal therapy. Doctors develop a treatment plan based on cancer type, location and stage.

A multimodal or multidisciplinary approach involves a combination of multiple treatments, such as surgery and chemotherapy, in a specific order based on the cancer stage.

Extrapleural pneumonectomy (lung removal) or pleurectomy and decortication (pleura removal) are mesothelioma surgeries that offer patients the best chance of survival.

More than 70% of mesothelioma patients undergo chemotherapy. These potent drugs shrink tumors and kill cancer cells but also have numerous side effects.

Doctors can administer mesothelioma radiation therapy at any cancer stage, often combined with surgery and chemotherapy. Radiation reduces pain and slows tumor growth.

Mesothelioma immunotherapy drugs control cancer growth using cells from the immune system. Immunotherapy eligibility and success rates vary for each patient.

The FDA-approved TTFields involves a battery-operated device worn on the skin in combination with chemotherapy to limit cancer growth.

Some patients may be eligible for mesothelioma clinical trials that test newer therapies. Though not every mesothelioma treatment is suitable for each patient, most patients can benefit from palliative care to help manage symptoms.

Because mesothelioma is a rare type of cancer, many patients are misdiagnosed or do not have access to specialized care. Finding a local mesothelioma treatment center is the best way to benefit from the latest therapies and improve a mesothelioma prognosis.

Mesothelioma cancer centers across the U.S. employ the top mesothelioma doctors who have years of experience treating patients, improving their prognoses and extending their life expectancies.

Top mesothelioma doctors across the U.S. include:

The life expectancy for mesothelioma patients is about 12 months with treatment. About 10% of patients with pleural mesothelioma and 65% with peritoneal mesothelioma live for five years or longer. Prognosis refers to the overall outlook of a patients cancer based on their response to treatment.

Alongside cancer treatments, a healthier lifestyle and nutrient-rich diet can improve the quality of life with a malignant mesothelioma diagnosis. For example, quitting smoking and receiving flu and pneumonia vaccinations improves lung function and overall health.

Learn about healthy eating with mesothelioma and take control of your diet. Get quick and easy recipes to ease cancer symptoms.

Many free resources, such as medical webinars and support groups, help patients and families better understand and cope after a diagnosis. General support options, caregiver resources and financial assistance can lower your familys emotional, physical and monetary burden.

Mesothelioma is a rare cancer that commonly develops in the thin tissue lining the lungs or abdomen. What makes this cancer unique is that it is caused almost exclusively by inhaling or ingesting asbestos fibers.

The terms mesothelioma and malignant mesothelioma usually refer to the cancerous and aggressive form of the disease. Non-cancerous or benign mesothelioma tumors can also occur throughout the body but do not spread as quickly and do not typically return after surgery.

Mesothelioma is not a form of lung cancer. While both are types of cancer, mesothelioma grows on the pleura lining the outside of the lungs, diaphragm and chest cavity. Lung cancer develops within the lung space. Both diseases share similar symptoms, such as shortness of breath and chest pain, and can occur after inhaling asbestos fibers.

Asbestos is the only proven cause of mesothelioma. The primary risk factor for mesothelioma is asbestos exposure from serving in the military or working jobs that involve handling products contaminated with asbestos.

Mesothelioma is incurable, though researchers continue investigating new therapy options in clinical trials. Some patients live several years beyond the average life expectancy, and recent treatment advancements, such as immunotherapy, provide patients hope for an eventual cure.

You may be eligible to seek compensation for mesothelioma from asbestos trust funds, lawsuits or VA claims. Financial assistance helps cover the cost of treatment expenses and lost wages. Speaking with a mesothelioma lawyer is the best way to learn about your legal options if you or a loved one has been diagnosed with mesothelioma.

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Dying from Mesothelioma | What to Expect and How to Support

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Due to the aggressive nature of mesothelioma, it is fatal for most patients. Patients and families should be aware of supportive care treatment options and other resources to prioritize symptom management and offer some relief. Knowing what to expect at the end of life can help relief anxiety and fear.

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Mesothelioma is an aggressive cancer that typically spreads rapidly and is mainly considered incurable. This means that for most patients, it is terminal. Some people may live with cancer for a few years, and some may even go into remission, but the general prognosis is poor.

The average mesothelioma life expectancy across the board is just 15 months. This includes all types of mesothelioma, diagnosed at any stage and for patients of all ages. Most will face dying from mesothelioma.

By stage IV, advanced metastatic has a greater effect on organs, leading to more symptoms, such as fatigue, pain, and weight loss. The symptoms of this late-stage mesothelioma include:

End-stage cancer can be very painful, but palliative care relieves most of this pain. When death is close at hand, most cancer patients experience certain symptoms in addition to those characteristics of the specific cancer type:

In the final days and hours of life, many patients stop eating or drinking. They often become withdrawn and unresponsive. They may be sleeping most of the time, finding it difficult to stay awake.

Most patients die from mesothelioma in stage 4, when the cancer has spread to other parts of the body and caused extensive damage.

Late-stage cancer causes organs to fail, impairs the immune system, causes malnutrition and wasting, and can even result in a coma. The actual cause of death at the end of mesothelioma is likely several factors, such as infections and organ failure.

Palliative care was once thought to be the same as hospice and giving up. It is not the same as hospice, and palliative care now has a vital role along with the oncology team during treatment.

More people are now aware of the benefits of incorporating palliative care at the time of diagnosis and continue through the treatment course. The primary role of palliative care is to focus on complex symptom management and ensure treatment decisions align with the patients goals for therapy.

Palliative care is any treatment that helps to improve the patients quality of life. A patients preference should always be prioritized in decisions regarding palliative care. Sometimes that even includes no treatment and focusing on symptom management alone.

Some options for end-stage mesothelioma patients include:

Medical care at the end of life is important, but so are other types of care. Therapy and counseling, and spiritual guidance bring comfort to many patients as they are dying. It is important to ask patients what kind of support they want and what they do not want.

Loved ones can support the patient in important ways. Simply being there is often comforting. Talk to the patient, touch them, read to them, watch movies, or sit together.

If they can still talk, let them express their feelings and any fears they have about dying. Dont avoid difficult subjects. Talk about memories and happy times, but be prepared to talk about tough things too.

It is also important to help your loved one make decisions during this time. You can bring them some relief by helping with practical things, like money or legal decisions. Work with financial counselors or a trusted lawyer to make this easier for both of you.

Designate a Medical Power of Attorney (MPOA) who can make medical decisions on behalf of the patient if they are unable to do so.

As a loved one is dying from mesothelioma, the family needs support as well. One of the best things you can do for your own mental health is to be there for your loved one. Provide the support and comfort they need as they choose it.

Family and loved ones can also benefit from therapy. Grief begins before your loved one passes away, and talking about it to a mental health professional is helpful. You may also find comfort in a support group for grieving. Listening to and sharing with people going through similar experiences helps you feel less alone and less afraid.

Technically speaking, hospice care provides palliative treatments for those with a terminal illness thought to have less than six months to live. The focus is on making patients feel better, so things such as chemotherapy and radiation will stop. It is possible to enroll and unenroll should that be the choice.

Your loved one may choose to receive care at home, known as home hospice care, or stay in a hospice facility with 24-hour care and supervision. At home, the primary caregiver is usually a family member with support from the medical staff.

Hospice care tries to meet all the needs of the patients through a team of professionals:

Hospice provides palliative medical care, alternative therapies, counseling, spiritual guidance, and recreation. Hospice teams may also include legal and financial professionals to help families make critical end-of-life decisions.

Daily activities such as bathing, dressing, or wound care are typically done by family members, with nursing staff coming out a few times a week, depending on the needs.

Hospice care benefits both patients and their families. With a care team taking charge, the pressure is taken off the family. The team offers options and guidance, and the patient and family can make more informed decisions with more confidence.

It is also important to understand that hospice is not just for patients in their final days or weeks of life. Medicare allows for hospice care for patients expected to live six months or less. Being in hospice may seem scary initially, but it can also provide great comfort and relief.

Yes, doctors can make mistakes when diagnosing mesothelioma and when determining a cause of death. However, it is more likely that mesothelioma is underreported as a cause of death. A pathologist might mistake a mesothelioma cause of death for lung cancer or another similar illness.

A study of cancer registry entries and causes of death found that this does happen frequently. The researchers compared deceased people diagnosed with mesothelioma during their lives with their death certificates.

They found that 10% of death certificates were incorrect. These certificates listed lung cancer, another cancer, or another cause of death when they should have listed mesothelioma.

Besides wanting to know what happened to your loved one, an accurate cause of death has practical implications. Most cases of mesothelioma are related to occupational asbestos exposure. For families to seek justice and get compensation from those responsible, they need proof of the cause of death.

If you feel uncomfortable or unsure about the cause of death listed on a death certificate, talk to a lawyer. You can challenge the cause of death, but you have to go through the proper channels, which vary by state. A lawyer will make sure you have the best chance of success and that you do everything correctly.

Facing death head-on isnt easy, but it is inevitable for patients dying of mesothelioma and their families. As the loved one of a patient with mesothelioma, know what to expect, what you can do to support them, and help them make decisions in their best interest.

Anne Courtney has a Doctor of Nursing Practice degree and is an Advanced Oncology Certified Nurse Practitioner. She has years of oncology experience working with patients with malignant mesothelioma, as well as other types of cancer. Dr. Courtney currently works at University of Texas LIVESTRONG Cancer Institutes.

References

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Dying from Mesothelioma | What to Expect and How to Support

Mesothelioma: Types, Causes, Symptoms & Treatment – Cleveland Clinic

OverviewCaused by exposure to chemicals like asbestos, mesothelioma affects the tissue that covers your organs.What is mesothelioma?

Mesothelioma refers to tumors that develop in the mesothelium, a type of tissue that makes up the lining of cavities or hollows that protect and surround certain organs. This tissue forms:

Most people think of cancer of the pleura when they hear the word mesothelioma. This type of mesothelioma is related to exposure to asbestos and is often cancerous.

There are different ways to refer to mesothelioma. One way is to determine if the tumor is cancerous (malignant mesothelioma) or not cancerous (benign mesothelioma). Other types refer back to the cavities formed by mesothelial tissue and are called:

Mesothelioma may also be divided into groups based on the type of cell that creates the tumor. These types are:

Mesothelioma is associated with exposure to asbestos, a naturally occurring mineral used in many industries. Its use is now regulated in the U.S. and safety measures are in place, but this hasnt always been true. People who were exposed 20 to 40 years ago are only now being diagnosed.

More men than women are affected by mesothelioma, at a rate of 3 to 1. Men in their 50s to their 70s represent most of the diagnoses.

Workers in the following industries were, and possibly still are, more at risk due to increased exposure to asbestos products:

Military veterans may have been exposed in many ways at military bases, on ships and in construction.

In childhood mesothelioma, asbestos doesnt seem to be an issue. Children who have had earlier types of cancer and have been treated with radiation therapy have a higher risk of developing mesothelioma.

Mesothelioma is considered a rare illness. Currently, there are an estimated 3,000 to 4,000 new cases of mesothelioma in the U.S. each year. Of the total, there are about 2,500 cases of malignant pleural mesothelioma.

You can have mesothelioma without symptoms, and you can have different symptoms depending on the type of mesothelioma you have. If you have any of the types of mesothelioma, its possible to have:

In adults, the main cause of mesothelioma is past exposure to asbestos fibers and dust. Between 70% and 80% of people with mesothelioma were exposed to asbestos, mostly through work. It takes over 20 years for symptoms to develop.

In smaller numbers, people have developed mesothelioma after exposure to similar minerals like silica and erionite. Erionite is a type of mineral (zeolite) thats been linked to mesothelioma.

Scientists are also investigating whether your genes contribute to your risk of developing mesothelioma. This is because only a small number of people who have been exposed to asbestos have developed mesothelioma.

Scientists are also looking into other causes, including exposure to chemicals, having viral infections and having radiation. Additionally, radiation therapy is associated with childhood mesothelioma.

Your healthcare provider will take your medical history and do a physical examination. Hearing your symptoms and listening to your chest will provide the first clues. Your provider will probably order a series of tests to make their diagnosis. These tests may include:

Treating mesothelioma depends on what type you have. Treatment is different for benign (noncancerous) mesothelioma than it is for malignant mesothelioma.

Benign mesothelioma tumors arent cancerous and dont spread (metastasize) to other parts of your body. They can grow in the pleura, in your abdomen and in the reproductive organs of men and women. Typically, your healthcare provider will remove them in a surgical procedure. They usually dont come back if they are completely removed. Some providers might suggest further treatment with chemotherapy in the case of some types of benign mesothelioma.

After youve been diagnosed with mesothelioma, your healthcare provider will use the information they have to assess how far the disease has progressed. This assessment is called staging and refers to cancers. Higher staging numbers typically mean that the disease has progressed, such as Stage III or Stage IV disease.

The most common type of cancerous mesothelioma is malignant pleural mesothelioma. But for all types of malignant mesothelioma, your options may include surgery, with or without chemotherapy or other therapies, or chemotherapy, radiation therapy and other types of therapy without surgery.

If your provider stages your tumor and youre able to have surgery, youll have surgery to remove the tumor. However, less than 33% of people with malignant pleural mesothelioma can have this type of surgery. You may or may not have chemotherapy or radiation therapy as well.

If you cant have surgery, the tumor is treated with chemotherapy and/or radiation. You may have an option to try treatments that are being studied, such as biologic agents and antiangiogenic therapies. Antiangiogenic treatments try to destroy cancer by making sure it doesnt have a blood supply.

Even though surgery and chemotherapy might be the best course of treatment, they may have complications such as:

The best way to prevent mesothelioma is to avoid asbestos and other harmful minerals. If you must be around asbestos, be sure to follow the guidelines for protective masks and clothing.

The prognosis for any type of malignant mesothelioma is poor. Many people die in the first four to six months after diagnosis and most by 12 months after diagnosis. However, some people have lived longer than that and a rare few were alive at the five-year mark.

If youve been treated for malignant melanoma, your mesothelioma specialist will probably want to see you on a specific schedule. Youll also want to see your primary care provider too. These providers will monitor your overall health and may do tests to see if cancer returns.

Ask, too, about ways to improve your life if you're having side effects of chemotherapy and radiation. There may be more options than you think.

Make sure that you know when you should contact a healthcare provider immediately for instance, if you have a fever or extreme dizziness. Then, follow those suggestions. Its always OK to contact your provider with any questions you might have.

Benign mesothelioma, or mesothelioma that isnt cancerous, isnt fatal. However, malignant mesothelioma is almost always fatal.

Part of the reason that malignant mesothelioma is so deadly is that it grows without symptoms for years. Another reason is that current treatment options arent that successful at treating the disease.

There are many different types of mesothelioma, so life expectancy estimates vary. And people are all different in terms of age, general health and other medical conditions. As always, youll probably have better results if mesothelioma is found early and treated as vigorously as possible.

A note from Cleveland Clinic

If you are someone who used to work with asbestos and you have trouble breathing, make the call to your healthcare provider to get checked out. If you do find out you have mesothelioma, work with your healthcare team to develop a plan for each type of possible outcome. This can mean getting as much information as you can and speaking to family and friends about whats going on. You might find it useful to join a support group or get some counseling. You might want to be involved in clinical studies if you can. Your healthcare team will provide support and information.

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Mesothelioma: Types, Causes, Symptoms & Treatment - Cleveland Clinic

What is cloud computing? Everything you need to know now

Cloud computing is an abstraction of compute, storage, and network infrastructure assembled as a platform on which applications and systems can be deployed quickly and scaled on the fly. Crucial to cloud computing is self-service: Users can simply fill in a web form and get up and running.

The vast majority of cloud customers consume public cloud computing services over the internet, which are hosted in large, remote data centers maintained by cloud providers. The most common type of cloud computing, SaaS (software as service), delivers prebuilt applications to the browsers of customers who pay per seat or by usage, exemplified by such popular apps as Salesforce, Google Docs, or Microsoft Teams. Next in line is IaaS (infrastructure as a service), which offers vast, virtualized compute, storage, and network infrastructure upon which customers build their own applications, often with the aid of providers API-accessible services.

When people casually say the cloud, they most often mean the big IaaS providers: AWS (Amazon Web Services), Google Cloud, or Microsoft Azure. All three have become gargantuan ecosystems of services that go way beyond infrastructure: developer tools, serverless computing, machine learning services and APIs, data warehouses, and thousands of other services. With both SaaS and IaaS, a key benefit is agility. Customers gain new capabilities almost instantly without capital investment in hardware or softwareand they can instantly scale the cloud resources they consume up or down as needed.

Way back in 2011, NIST posted a PDF that divided cloud computing into three service modelsSaaS, IaaS, and PaaS (platform as a service)the latter a controlled environment within which customers develop and run applications. These three categories have largely stood the test of time, although most PaaS solutions now make themselves available as services within IaaS ecosystems rather than presenting themselves as their own clouds.

Two evolutionary trends stand out since NISTs threefold definition. One is the long and growing list of subcategories within SaaS, IaaS, and PaaS, some of which blur the lines between categories. The other is the explosion of API-accessible services available in the cloud, particularly within IaaS ecosystems. The cloud has become a crucible of innovation where many emerging technologies appear first as services, a big attraction for business customers who understand the potential competitive advantages of early adoption.

This type of cloud computing delivers applications over the internet, typically with a browser-based user interface. Today, the vast majority of software companies offer their wares via SaaSif not exclusively, then at least as an option.

The most popularSaaS applications for business can be found in Googles G Suite and Microsofts Office 365; most enterprise applications, including giant ERP suites from Oracle and SAP, come in both SaaS and on-prem versions. SaaS applications typically offer extensive configuration options as well as development environments that enable customers to code their own modifications and additions. They also enable data integration with on-prem applications.

At a basic level,IaaS cloud providers offer virtualized compute, storage, and networking over the internet on a pay-per-use basis. Think of it as a data center maintained by someone else, remotely, but with a software layer that virtualizes all those resources and automates customers ability to allocate them with little trouble.

But thats just the basics. The full array of services offered by the major public IaaS providers is staggering:highly scalable databases, virtual private networks,big dataanalytics, developer tools,machine learning, application monitoring, and so on.Amazon Web Serviceswas the first IaaS provider and remains the leader, followed by Microsoft Azure,Google Cloud Platform, Alibaba Cloud, andIBM Cloud.

PaaS provides sets of services and workflows that specifically target developers, who can use shared tools, processes, and APIs to accelerate the development, testing, and deployment of applications. Salesforces Heroku and Salesforce Platform (formerly Force.com) are popular public cloud PaaS offerings; Cloud Foundry and Red Hats OpenShift can be deployed on premises or accessed through the major public clouds. For enterprises, PaaS can ensure that developers have ready access to resources, follow certain processes, and use only a specific array of services, while operators maintain the underlying infrastructure.

FaaS, the cloud version of serverless computing, adds another layer of abstraction to PaaS, so that developers are completely insulated from everything in the stack below their code. Instead of futzing with virtual servers, containers, and application runtimes, developers upload narrowly functional blocks of code, and set them to be triggered by a certain event (such as a form submission or uploaded file). All the major clouds offer FaaS on top of IaaS: AWS Lambda,Azure Functions, Google Cloud Functions, and IBM Cloud Functions. A special benefit of FaaS applications is that they consume no IaaS resources until an event occurs, reducing pay-per-use fees.

A private cloud downsizes the technologies used to run IaaS public clouds into software that can be deployed and operated in a customers data center. As with a public cloud, internal customers can provision their own virtual resources to build, test, and run applications, with metering to charge back departments for resource consumption. For administrators, the private cloud amounts to the ultimate in data center automation, minimizing manual provisioning and management. VMware provides the most popular commercial private cloud software, while OpenStack is the open source leader.

Note, however, that the private cloud does not fully conform to the definition of cloud computing. Cloud computing is a service. A private cloud demands that an organization build and maintain its own underlying cloud infrastructure; only internal users of a private cloud experience it as a cloud computing service.

A hybrid cloud is the integration of a private cloud with a public cloud. At its most developed, the hybrid cloud involves creating parallel environments in which applications can move easily between private and public clouds. In other instances, databases may stay in the customer data center and integrate with public cloud applicationsor virtualized data center workloads may be replicated to the cloud during times of peak demand. The types of integrations between private and public cloud vary widely, but they must be extensive to earn a hybrid cloud designation.

Just as SaaS delivers applications to users over the internet, public APIs offer developers application functionality that can be accessed programmatically. For example, in building web applications, developers often tap into the Google Maps API to provide driving directions; to integrate with social media, developers may call upon APIs maintained by Twitter, Facebook, or LinkedIn. Twilio has built a successful business delivering telephony and messaging services via public APIs. Ultimately, any business can provision its own public APIs to enable customers to consume data or access application functionality.

Data integration is a key issue for any sizeable company, but particularly for those that adopt SaaS at scale. iPaaS providers typically offer prebuilt connectors for sharing data among popular SaaS applications and on-premises enterprise applications, though providers may focus more or less on business-to-business and e-commerce integrations, cloud integrations, or traditional SOA-style integrations. iPaaS offerings in the cloud from such providers as Dell Boomi, Informatica, MuleSoft, and SnapLogic also let users implement data mapping, transformations, and workflows as part of the integration-building process.

The most difficult security issue related to cloud computing is the management of user identity and its associated rights and permissions across private data centers and pubic cloud sites. IDaaS providers maintain cloud-based user profiles that authenticate users and enable access to resources or applications based on security policies, user groups, and individual privileges. The ability to integrate with various directory services (Active Directory, LDAP, etc.) and provide single sign-on across business-oriented SaaS applications is essential. Okta is the clear leader in cloud-based IDaaS; CA, Centrify, IBM, Microsoft, Oracle, and Ping provide both on-premises and cloud solutions.

Collaboration solutions such as Slack and Microsoft Teams have become vital messaging platforms that enable groups to communicate and work together effectively. Basically, these solutions are relatively simple SaaS applications that support chat-style messaging along with file sharing and audio or video communication. Most offer APIs to facilitate integrations with other systems and enable third-party developers to create and share add-ins that augment functionality.

Key providers in such industries as financial services, health care, retail, life sciences, and manufacturing provide PaaS clouds to enable customers to build vertical applications that tap into industry-specific, API-accessible services. Vertical clouds can dramatically reduce the time to market for vertical applications and accelerate domain-specific B-to-B integrations. Most vertical clouds are built with the intent of nurturing partner ecosystems.

The most widely accepted definition of cloud computing means that you run your workloads on someone elses servers, but this is not the same as outsourcing. Virtual cloud resources and even SaaS applications must be configured and maintained by the customer. Consider these factors when planning a cloud initiative.

Objections to the public cloud generally begin with cloud security, although the major public clouds have proven themselves much less susceptible to attack than the average enterprise data center.

Of greater concern is the integration of security policy and identity management between customers and public cloud providers. In addition, government regulation may forbid customers from allowing sensitive data off premises. Other concerns include the risk of outages and the long-term operational costs of public cloud services.

The bar to qualify as a multicloud adopter is low: A customer just needs to use more than one public cloud service. However, depending on the number and variety of cloud services involved, managing multiple clouds can become quite complex from both a cost optimization and technology perspective.

In some cases, customers subscribe to multiple cloud services simply to avoid dependence on a single provider. A more sophisticated approach is to select public clouds based on the unique services they offer and, in some cases, integrate them. For example, developers might want to use Googles TensorFlow machine learning service on Google Cloud Platform to build AI-driven applications, but prefer Jenkins hosted on the CloudBees platform for continuous integration.

To control costs and reduce management overhead, some customers opt for cloud management platforms (CMPs) and/or cloud service brokers (CSBs), which let you manage multiple clouds as if they were one cloud. The problem is that these solutions tend to limit customers to such common-denominator services as storage and compute, ignoring the panoply of services that make each cloud unique.

You often see edge computing described as an alternative to cloud computing. But it is not. Edge computing is about moving compute to local devices in a highly distributed system, typically as a layer around a cloud computing core. There is typically a cloud involved to orchestrate all the devices and take in their data, then analyze it or otherwise act on it.

The clouds main appeal is to reduce the time to market of applications that need to scale dynamically. Increasingly, however, developers are drawn to the cloud by the abundance of advanced new services that can be incorporated into applications, from machine learning to internet of things (IoT) connectivity.

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What is cloud computing? Everything you need to know now

What is Private Cloud? | IBM

Private cloud is a cloud computing environment dedicated to a single customer. It combines many of the benefits of cloud computing with the security and control of on-premises IT infrastructure.

Private cloud (also known as an internal cloud or corporate cloud) is a cloud computing environment in which all hardware and software resources are dedicated exclusively to, and accessible only by, a single customer. Private cloud combines many of the benefits of cloud computingincluding elasticity, scalability, and ease of service deliverywith the access control, security, and resource customization of on-premises infrastructure.

Many companies choose private cloud over public cloud (cloud computing services delivered over infrastructure shared by multiple customers) because private cloud is an easier way (or the only way) to meet their regulatory compliance requirements. Others choose private cloud because their workloads deal with confidential documents, intellectual property, personally identifiable information (PII), medical records, financial data, or other sensitive data.

By building private cloud architecture according to cloud native principles, an organization gives itself the flexibility to easily move workloads to public cloud or run them within a hybridcloud (mixed public and private cloud) environment whenever theyre ready.

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What is Private Cloud? | IBM

What is a Private Cloud – Definition | Microsoft Azure

The private cloud is defined as computing services offered either over the Internet or a private internal network and only to select users instead of the general public. Also called an internal or corporate cloud, private cloud computing gives businesses many of the benefits of apublic cloud- including self-service, scalability, and elasticity - with the additional control and customization available from dedicated resources over a computing infrastructure hosted on-premises. In addition, private clouds deliver a higher level of security and privacy through both company firewalls and internal hosting to ensure operations and sensitive data are not accessible to third-party providers. One drawback is that the companys IT department is held responsible for the cost and accountability of managing the private cloud. So private clouds require the same staffing, management, and maintenance expenses as traditional datacenter ownership.

Two models for cloud services can be delivered in a private cloud. The first isinfrastructure as a service (IaaS)that allows a company to use infrastructure resources such as compute, network, and storage as a service. The second isplatform as a service (PaaS)that lets a company deliver everything from simple cloud-based applications to sophisticated-enabled enterprise applications. Private clouds can also be combined with public clouds to create ahybrid cloud, allowing the business to take advantage ofcloud burstingto free up more space and scale computing services to the public cloud when computing demand increases.

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What is a Private Cloud - Definition | Microsoft Azure

80 Best Cloud Computing Blogs and Websites – Feedspot Blog

1. CloudTech

Bristol, England, UKCovers SaaS news, cloud computing jobs, virtualization strategy, cloud apps and enterprise IT, private and public cloud, system security, cloud apps, CRM, and cloud communications. Cloud Tech provides the latest insight that enables CIOs to make informed decisions about IT strategy. cloudcomputing-new.. 24.3K 3 posts / week Get Email Contact

An expert's opinion, the best way to defend against scam spam, trending articles, and technology innovation of the Cloud Computing industry. CIOReview is a technology magazine that talks about enterprise solutions. cloud.cioreview.com 2K 4 posts / day Get Email Contact

USTechRepublic provides IT professionals with a unique blend of original content, peer-to-peer advice from the largest community of IT leaders. This section of the TechRepublic blog features Cloud content, resources, thought leadership, and expert guidance. techrepublic.com/t.. 921.7K 7 posts / week Get Email Contact

Seattle, Washington, USLatest news and information on AWS. Amazon Web Services offers reliable, scalable, and inexpensive cloud computing services. aws.amazon.com/blo.. 831.3K 9 posts / month Nov 2004 Get Email Contact

Vancouver, British Columbia, CanadaCovers cloud computing, SaaS, Big Data, Wearable Tech, and the Internet of Everything news and information. CloudTweaks connects brands to an influential audience made of business owners and managers of growing businesses, entrepreneurs, and early adopters. Also in Cloud Computing Magazines cloudtweaks.com 4.3K 1 post / week Get Email Contact

Redmond, Washington, USThe latest Azure news, product updates, and announcements from Azure experts. Azure is an open and flexible cloud computing platform created by Microsoft. Also in Microsoft Blogs, Microsoft Azure Blogs azure.microsoft.co.. 665.7K 12 posts / month Sep 2008 Get Email Contact

Palo Alto, California, USThe blog about VMware cloud services, products, news, and updates. VMware is a cloud computing and virtualization technology company that provides cloud solutions. blogs.vmware.com/c.. 371.9K 9 posts / month Get Email Contact

Seattle, Washington, USA blog about building scalable and robust distributed systems. Authored by Werner Vogels, a Chief Technology Officer at Amazon.com. allthingsdistribut.. 1 post / month Get Email Contact

This section of our blog features articles that have to do exclusively with cloud computing. Cisco is the worldwide leader in IT, networking, and cybersecurity solutions. blogs.cisco.com/cloud 2M 369.3K 2 posts / month Get Email Contact

Get the latest cloud insights, news, and recommendations from the HPE GreenLake blog. Hewlett Packard Enterprise is an industry-leading enterprise technology company that simplifies Hybrid IT community.hpe.c.. 300.1K 1 post / week Dec 2020 Get Email Contact

Mountain View, California, USGoogle Cloud Platform's blog contains hundreds of articles written by Google cloud experts and actually dates back to 2008. This vast blog discusses the products, customers, and technical features of Google's cloud solution, while articles can range from product blurbs to extremely detailed technical explanations. cloud.google.com/blog 1.2M 30 posts / month Get Email Contact

San Francisco, California, USThis section of the website features articles that have to do exclusively with cloud computing news. InfoWorld is a technology media company that provides analysis and hands-on expertise in the form of reviews and how-to articles. infoworld.com/cate.. 74.3K 4 posts / week Get Email Contact

Find cloud computing News, how-tos, features, reviews, and videos on Computerworld. computerworld.com/.. 906.9K 1 post / month Get Email Contact

San Mateo, California, USSnowflake's blog Inside the Cloud Data gives you details about around the company, thought leadership, their product and technology, data warehousing, and much more. Snowflake's founders engineered Snowflake to power the Data Cloud, where thousands of organizations have seamless access to explore, share, and unlock the true value of their data. Also in Data Engineering Blogs, Data Warehousing Blogs snowflake.com/blog 13.5K 2 posts / week Get Email Contact

London, England, UKCompare the Cloud is the web's premier resource for researching cloud computing and associated technologies ranging from AI to Machine learning and IoT. comparethecloud.net 381 2 posts / week Get Email Contact

Singapore, Singapore, SingaporeThe Cloud Security Alliance (CSA) leads the industry in offering cloud security-specific research, education, certification, events, and best practices. cloudsecurityallia.. 1.9K 6 posts / week Get Email Contact

Norwalk, Connecticut, USCovers the latest expert news, reviews & resources tailored specifically for Cloud Computing. TMCnet is the leading resource in VoIP, IP, Communications, CallCenters, CRM, & Telecom. cloud-computing.tm.. 858 13 posts / month Get Email Contact

The Diversity Limited blog is written by Ben Kepes, who is a technology evangelist, investor, commentator, and business advisor. The blog provides great analysis of all the latest cloud-related tech news and commentary on newly released business software. Despite being a one-man show, the blog includes hundreds of articles and is sometimes updated a few times a day. diversity.net.nz 2.7K 1.4K 1 post / week Get Email Contact

Pompano Beach, Florida, USBoost your business with additional pace using application hosting services from Ace Cloud Hosting. Best advice, research, how-tos, and insights to help your accounting and cloud technology practices. ACE is a renowned Cloud Solutions Provider and has established itself as a leader in Application Hosting, Managed Security Services, Public Cloud, and Hosted Virtual Desktop Solutions. acecloudhosting.co.. 545 10 posts / week Get Email Contact

London, England, UKOur aim is to assist IT professionals to navigate an increasingly cluttered information landscape by understanding the real issues and consistently delivering relevant, high-quality content to enrich knowledge and expertise. Subscribe us to keep up with latest Cloud Computing Articles from ComputerworldUK computerworld.com/.. 3K 1 post / week Get Email Contact

Berlin, GermanyCovers best news, articles, tips & reviews all around the cloud. Cloudwards reviews software & privacy tools to keep your data and identity safe. cloudwards.net/art.. 625 9 posts / week Get Email Contact

SwitzerlandCharbel Nemnom is a Cloud Solutions Architect and Microsoft MVP and a totally fan of the latest's IT platform solutions. Keep up with updates on data center management solutions and a lot more. charbelnemnom.com 193 116 1 post / day Get Email Contact

Boston, Massachusetts, USRick's Cloud is a Cloud Computing Blog by Rick Blaisdell. rickscloud.com 1 post / week Get Email Contact

San Francisco, California, USStay up-to-date on the latest technology trends and best practices on everything cloud with technical cloud feature announcements, industry trends, and training material. Cloud Academy is a technology training platform for enterprise multi-cloud infrastructure. cloudacademy.com/blog 18K 6 posts / month Get Email Contact

USFounded in 2011 as one of the world's first cloud-to-cloud backup services for Google Apps and Salesforce, CloudAlly led the industry and pioneered the first commercially available Microsoft Office 365 cloud backup in 2014. The blog provides cloud to cloud backup solutions for Office 365, G Suite, Sharepoint, Box. cloudally.com/blog 4 posts / month Get Email Contact

Orlando, Florida, USBuild5Nines is your trusted source for cloud and enterprise technology information and all the tutorials, articles and videos are focused on helping you to be more productive with it. build5nines.com 2 posts / week Get Email Contact

Montreal, Quebec, CanadaThis blog includes launches, basic cloud computing articles, and any news or updates on their CloudConsole. VEXXHOST is a leading Canadian OpenStack cloud infrastructure as a service (IaaS) provider for private, public, and hybrid clouds. vexxhost.com/blog 991 1.1K 1 post / quarter Get Email Contact

Wales, UKMy name is John Lunn and I am a Microsoft Technical Architect focussed on Microsoft's Cloud Services of Azure and M365 for BT Enterprise who are my full time employer. I have always been a Science and Technology enthusiast, so working with Technology is a great way to get paid to do your hobby! I have over 20 years working experience within IT ranging from analyst to developer, from consulting to architecture. jonnychipz.com/blo.. 1 post / week Jan 2014 Get Email Contact

Kolkata, West Bengal, IndiaWelcome to CloudKatha - A platform, where we will be sharing our experience of designing, developing, and deploying applications into the AWS cloud environment. Also in AWS Blogs cloudkatha.com 214 4 posts / month Jul 2020 Get Email Contact

Maharashtra, IndiaBlazeclan is a born-in-cloud, strategic partner of choice to organizations that want to deliver business excellence using the cloud as a tool. Read the Blazeclan Blog for new ideas, the latest updates, and discussion around cloud computing from leading industry experts. blazeclan.com/blog 1.5K 1 post / week Get Email Contact

CanadaCovers cloud technology insights from cloud experts. WatServ is an IT solutions provider that helps clients digitally transform their business through cloud technologies and managed services. watserv.com/blog 69 2 posts / week Get Email Contact

Bangalore, Karnataka, IndiaStay up-to-date on the latest technology trends and best practices on Amazon Web Services (AWS). Also read articles and resources on AWS Digital transformation. Rapyder Cloud Solutions is Cloud Company, with expertise in Cloud Computing Solutions, Big Data, Marketing & Commerce, DevOps and Managed Service. rapyder.com/blogs 1.2K 3 posts / month Apr 2017 Get Email Contact

Los Angeles, California, USWe are a CIO strategic advisory firm leading companies through business and digital transformation while leveraging emerging technologies. AVOA is a research and advisory services firm that works with both enterprise end-users and vendors focusing on the intersection of business & technology. Also in CIO Blogs avoa.com 2 posts / week Get Email Contact

Chandler, Arizona, USBlog Posts and Technical Articles from Cloud Computing Technologies on topics of Agile Software Development, Microservices, and Kubernetes. cloudcomputingtech.. 1 post / week Get Email Contact

Herndon, Virginia, USIdexcel is a professional IT services and AWS cloud consulting company specializing in aws cloud services, application services and data services. idexcel.com/blog 1.8K 9 posts / year Jun 2014 Get Email Contact

Updates on enterprise insights, agile business, digital reimagination, and assurance from the cloud leader. Suneratech is a leading cloud-based platforms and enterprise solutions provider specializing in Oracle applications and technologies. suneratech.com/blog 2K 4 posts / quarter Feb 2016 Get Email Contact

ItalySilvio Di Benedetto is founder and CEO at Inside Technologies. He provides latest insight on Microsoft, Azure, Windows Server, Active Directory, Data Protection Manager, Veeam Backup & Replication, Virtualization, Windows Server 2016. His experience includes leading and managing process and operations for different kind of projects. silviodibenedetto.com 91 2 posts / quarter Get Email Contact

IndiaEverything you want to know about cloud and virtualization. Keep yourself updated with the latest cloud technologies. cloudwithease.com 9.3K 13 posts / month Get Email Contact

Posts about Cloud written by Tech Wizard (Sukhija Vikas) techwizard.cloud/c.. 1.8K 2 posts / month May 2010 Get Email Contact

Anto Online, the anything Cloud related blog! Learn about PHP, Linux, AWS and more. anto.online 1 post / month Apr 2018 Get Email Contact

At Devrims official blog, we cover all relevant Cloud Industry news, insights, App tutorials, tips, and useful resources for our users & readers. Devrims is an Aggregator of the Website Hosting Solutions with an advanced Managed Cloud Hosting Platform where users can host their websites on their Own Terms. devrims.com/blog 96 1 post / month Get Email Contact

SingaporeWe are cloud thinkers, engineers and transformation enablers. Having pioneered cloud transformation and migration projects for multi-billion dollar businesses across the globe, we bring you the best of cloud practices, frameworks and domain knowledge. We are cloud thinkers, engineers and transformation enablers. As a born-in-cloud company, everyone in the team thinks 'cloud-first'. 1cloudhub.com/blog 2 posts / month Get Email Contact

San Jose, California, USCisco is the worldwide technology leader that has been making the Internet work. Our people, products, and partners help society securely connect and seize tomorrow's digital opportunity today. Follow to keep up with cloud computing articles from Cisco. blogs.cisco.com/ta.. 2M 377.2K Jun 2010 Get Email Contact

Armonk, New York, USThoughts on Cloud is a leading source of insights, news and analysis for the cloud community, presented by IBM and powered by exclusive commentary from IBM thought leaders and industry experts, along with curated, relevant cloud computing news from around the globe. Also in IBM Blogs ibm.com/blogs/clou.. 241.4K Jun 2011 Get Email Contact

USThe blog covers a range of topics, including Amazon AWS, Azure, Cloud Hosting, Windows Cloud Servers, Windows VPS Hosting, and Hosting Enhancements. Applied Innovations is a cloud services provider specializing in Microsoft server cloud technologies. appliedi.net/blog 1.6K Get Email Contact

Washington, District of Columbia, USCloud Pundit is the blog of Lydia Leong, who covers cloud computing for Gartner as a Distinguished Analyst. This in-depth blog often discusses the findings and opinions that Lydia generates from her professional analyses, and is updated approximately once a month. cloudpundit.com 3 posts / year Get Email Contact

Virginia, USKevin Jackson is a renowned thought leader, speaker, and consultant for cloud-related technologies and business strategies. Kevin's blog discusses issues related to cloud computing and cyber security, and includes news on product launches, acquisition, and conferences. kevinljackson.blog.. Get Email Contact

West Rockport, Maine, USThe innovative THINKstrategies blog is written by Jeff Kaplan, who is its Managing Director. A leading expert in cloud computing, Jeff is a frequent guest blogger and keynote speaker on SaaS, managed services, and IOT. Also in CRM Blogs, SAAS Blogs thinkstrategies.co.. Get Email Contact

Boston, Massachusetts, USBlog posts cover industry news, cloud security, enterprise cloud storage, cloud backup, and product updates. Nasuni is the leading provider of cloud file services. nasuni.com/blog 2.1K 12 posts / year Get Email Contact

Seattle, Washington, USLearn all about Kubernetes vs Docker, K8S concepts, cloud security & compliance, and everything on Managed Kubernetes. Magalix is a cloud security enabler, leveraging security-as-code and compliance-as-code, to embed security at every stage of the software development lifecycle. magalix.com/blog 1.2K 30 posts / year Get Email Contact

USCloud Management Insider (CMI) is a community platform to keep you updated about all the disruptions happening in cloud domain. CMI exists with the sole purpose of simplifying the complex cloud ecosystem. The hunger for learning everything about Cloud; and delivering that information in the best possible way is what drives us. This is what gets us out of bed every morning and makes us hustle. cloudmanagementins.. 563 35 Get Email Contact

Atlanta, Georgia, USWe empower purposeful, performance-driven IT transformation through our portfolio of high-density colocation, managed cloud hosting, and network services. Check out quality cloud related articles here. inap.com/blog/cate.. 1.2K Get Email Contact

Cloud business reviews, trends, solutions, applications and services. cbrdigital.com 205 3 posts / year Get Email Contact

Athens, Attiki, GreeceKeep up with articles from George Markou. markou.me 5 posts / year Apr 2016 Get Email Contact

Los Angeles, California, USArticles to learn about cloud computing, VPS tips & tricks, Linux apps, and OS distros. SkySilk is a cloud services company that offers custom VPS solutions. skysilk.com/blog 2.8K Get Email Contact

Princeton, New Jersey, USThe industry's keenest insights on all news related to contemporary cloud computing. cloud-computing-to.. 3K Get Email Contact

Miami, Florida, USitopia is an automation & orchestration platform built for Google Cloud. We simplify the delivery and management of remote desktops & apps on any device itopia.com/blog 2 posts / year Get Email Contact

IndiaWe help businesses stay ahead of the curve by building solutions that enable smarter convergence of technology. indiqus.com/blog 8 posts / year Get Email Contact

AustraliaThis section of the FileWhopper Blog contains articles with reviews and fresh news on cloud storage services. FileWhopper is an online service that lets users quickly and safely transfer large files and folders over the internet. filewhopper.com/bl.. 131 Get Email Contact

Austin, Texas, USVirtasant is a leading provider of cloud, product development, and outsourcing services. We're all about the cloud. We were built in the cloud, and we function fully in the cloud. We have thousands of passionate architects, engineers, and creators working to help companies and people thrive in the cloud. With so much expert knowledge around cloud transformation, engineering, cloud architecture, cloud optimization, project management, remote work, and diversity - we have a lot to say. virtasant.com/blog 2 posts / month Jan 2020 Get Email Contact

UKContent on this site covers Cloud and all its variations of SaaS, PaaS, IaaS, Public, Private & Hybrid and its uses such as IOT (Internet of Things) and a little on sales sometimes. cloudmatters.cloud 1 post / quarter Feb 2016 Get Email Contact

GreeceStefanos Evangelou is a Cloud Computing consultant, trainer and author. Follow to get updates from this blog. stefanos.cloud/blog 29 posts / year Get Email Contact

cloudmantra is a 'born in the cloud' company that brings power of the cloud to organizations and consumers. As a leading technology services company, cloudmantra brings cutting-edge yet meaningful products & services to business and consumers globally. cloudmantra.net/blogs 360 1 post / year Get Email Contact

Amsterdam, Noord-Holland, NetherlandsThe Cloud Navigator brings diverse perspectives on the world of emerging technologies powered by the Cloud that grows in impact every day. thecloudnavigator.com 42 Get Email Contact

The cloud blog is a place where you can find all the information related to cloud transformation into the real world. thecloudblog.in Get Email Contact

CloudStack-Group solves the toughest challenges by providing unmatched services in strategy, consulting, digital, technology, and operations. We are your Cloud Experts. Cloudstack-Group, your technology partner on the journey from the data center to cloud. cloudstackgroup.co.. 962 1 post / year Get Email Contact

Nthacloud provides enterprise class private cloud technology at a per user price including hardware, operating software, support, internet service, remote desktop, data protection, and compliance requirements all for a fixed monthly price. nthacloud.com/blog 65 Get Email Contact

More Bloggers and Journalists covering Cloud Computing

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Austin, Texas, USRCR Wireless News has been providing wireless and mobile industry news, insights, and analysis to mobile and wireless industry professionals, decision-makers, policymakers, analysts and investors. Our mission is to connect, globally and locally, mobile technology professionals and companies online, in person, in print and on video. rcrwireless.com 5.9K Equinix CEO: The service provider world is very different Making sure you are really getting 5G (Reader Forum) Singularities in cellular (Analyst Angle)

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80 Best Cloud Computing Blogs and Websites - Feedspot Blog

Who Coined ‘Cloud Computing’? | MIT Technology Review

OSullivan thinks it could have been his ideaafter all, why else would he later try to trademark it? He was also a constant presence at Compaqs Texas headquarters at the time. OSullivan located a daily planner, dated October 29, 1996, in which he had jotted down the phrase Cloud Computing: The Cloud has no Borders following a meeting with Favaloro that day. That handwritten note and the Compaq business plan, separated by two weeks, are the earliest documented references to the phrase cloud computing that Technology Review was able to locate.

There are only two people who could have come up with the term: me, at NetCentric, or George Favaloro, at Compaq or both of us together, brainstorming, says OSullivan.

Both agree that cloud computing was born as a marketing term. At the time, telecom networks were already referred to as the cloud; in engineering drawings, a cloud represented the network. What they were hunting for was a slogan to link the fast-developing Internet opportunity to businesses Compaq knew about. Computing was bedrock for Compaq, but now this messy cloud was happening, says Favaloro. And we needed a handle to bring those things together.

Their new marketing term didnt catch fire, howeverand its possible others independently coined the term at a later date. Consider the draft version of a January 1997 Compaq press release, announcing its investment in NetCentric, which described the deal as part of a strategic initiative to provide Cloud Computing to businesses. That phrase was destined to be ages ahead of its time, had not Compaqs internal PR team objected and changed it to Internet computing in the final version of the release.

In fact, Compaq eventually dropped the term entirely, along with its plans for Internet software. That didnt matter to Favaloro. Hed managed to point Compaq (which later merged with HP) toward what became a huge business selling servers to early Internet providers and Web-page hosters, like UUNet. Its ridiculous now, but the big realization we had was that there was going to be an explosion of people using servers not on their premises, says Favaloro. I went from being a heretic inside Compaq to being treated like a prophet.

For NetCentric, the cloud-computing concept ended in disappointment. OSullivan gave up using the term as he struggled to market an Internet fax serviceone app the spotty network cloud of the day could handle. Eventually, the company went belly up and closed its doors. We got drawn down a rathole, and we didnt end up launching a raft of cloud computing apps thats something that sticks with me, says OSullivan, who later took a sabbatical from the tech world to attend film school and start a nonprofit to help with the reconstruction of Iraq.

Favaloro now heads an environmental consulting firm in Waltham, Massachussetts. What is remarkable, he says, is that the cloud he and OSullivan imagined 15 years ago has become a reality. I now run a 15-person company and, in terms of making us productive, our systems are far better than those of any of big company. We bring up and roll out new apps in a matter of hours. If we like them, we keep them, if not, we abandon them. We self-administer, everything meshes, we have access everywhere, its safe, its got great uptime, its all backed up, and our costs are tiny, says Favaloro. The vision came true.

Excerpt from:

Who Coined 'Cloud Computing'? | MIT Technology Review

Introduction to Cloud Computing – Apprenda

Cloud computing consists of three distinct types of computing services delivered remotely to clients via the internet. Clients typically pay a monthly or annual service fee to providers, to gain access to systems that deliver software as a service, platforms as a service and infrastructure as a service to subscribers. Clients who subscribe to cloud computing services can reap a variety of benefits, depending on their particular business needs at a given point in time. The days of large capital investments in software and IT infrastructure are now a thing of the past for any enterprise that chooses to adopt the cloud computing model for procurement of IT services. The ability to access powerful IT resources on an incremental basis is leveling the playing field for small and medium sized organizations, providing them with the necessary tools and technology to compete in the global marketplace, without the previously requisite investment in on premise IT resources. Clients who subscribe to computing services delivered via the cloud are able to greatly reduce the IT service expenditures for their organizations; and gain access to more agile and flexible enterprise level computing services, in the process.

Saas (Software as a Service) provides clients with the ability to use software applications on a remote basis via an internet web browser. Software as a service is also referred to as software on demand.

Clients can access SaaS applications from anywhere via the web because service providers hostapplications and their associated data at their location. The primary benefit of SaaS, is a lower cost of use, since subscriber fees require a much smaller investment than what is typically encountered under the traditional model of software delivery. Licensing fees, installation costs, maintenance fees and support fees that are routinely associated with the traditional model of software delivery can be virtually eliminated by subscribing to the SaaS model of software delivery. Examples of SaaS include: Google Applications and internet based email applications like Yahoo! Mail, Hotmail and Gmail.

PaaS (Platform as a Service) provides clients with the ability to develop and publish customizedapplications in a hosted environment via the web. It represents a new model for software developmentthat is rapidly increasing in its popularity. An example of PaaS is Salesforce.com. PaaS provides aframework for agile software development, testing, deployment and maintenance in an integratedenvironment. Like SaaS, the primary benefit of PaaS, is a lower cost of use, since subscriber fees require a much smaller investment than what is typically encountered when implementing traditional tools for software development, testing and deployment. PaaS providers handle platform maintenance and system upgrades, resulting in a more efficient and cost effective solution for enterprise softwaredevelopment.

IaaS (Infrastructure as a Service) allows clients to remotely use IT hardware and resources on a pay-as-you-go basis. It is also referred to as HaaS (hardware as a service). Major IaaS players include companies like IBM, Google and Amazon.com. IaaS employs virtualization, a method of creating and managing infrastructure resources in the cloud. IaaS provides small start up firms with a major advantage, since it allows them to gradually expand their IT infrastructure without the need for large capital investments in hardware and peripheral systems.

Originally posted here:

Introduction to Cloud Computing - Apprenda