30.11.2012 - (idw) Deutsches Zentrum fr Neurodegenerative Erkrankungen e.V. (DZNE)

Joint Press Release from the German Center for Neurodegenerative Diseases and the University Medical Center Gttingen

Researchers at the German Center for Neurodegenerative Diseases (DZNE) and the University Medical Center Gttingen (UMG) have identified an enzyme as a possible target for the treatment of Alzheimers disease. The protein known as HDAC6 impairs transport processes within the nerve cells. The scientists observed only mild symptoms of the disease in mice if the enzyme was not produced. They propose to block its activity in a targeted fashion to treat the disease. Scientists from the DZNE sites in Gttingen and Bonn, the UMG as well as from the US participated in this basic research project on Alzheimers disease. The study is published in "EMBO Molecular Medicine".

The researchers led by Prof. Andr Fischer, Department of Psychiatry and Psychotherapy at the University Medical Center Gottingen and Site Speaker of the DZNE in Gttingen, investigated mice with a modified genetic background. The animals showed behavioural disorders and brain deposits that are typically associated with Alzheimers disease. The researchers went a step further with a group of other animals by removing the genes responsible for the production of the HDAC6 enzyme (histone deacetylase 6). This intervention proved to be effective: while these mice also exhibited the pathological features of Alzheimers disease in the brain, their behaviour was significantly ameliorated. "The animals ability to learn and to find their spatial bearings was relatively normal", says Prof. Fischer. "Their cognitive abilities were fully comparable to those of healthy mice."

Improved cellular traffic

In the researchers view, this effect is at least partly attributable to the fact that important transport processes within the nerve cells are facilitated when the HDAC6 enzyme is not around. This meant in particular that the cells power plants, also known as "mitochondria", can travel to their final destinations. "It is known that in various neurodegenerative diseases cellular transport is no longer functional. The substances that are to be transported along axons are left behind", Fischer says. "Measures which improve trafficking seem to have a positive effect."

Possible target for therapy?

The researchers findings suggest that the HDAC6 enzyme could be a possible target for therapies against Alzheimers disease. However, treatments would require an active substance that can disable the enzyme in a targeted fashion. Unfortunately, the active substances known to date are too unspecific. Prof. Fischer explains that their application resembles a broad-spectrum treatment: "We dont know precisely what is the therapeutic effect of the inhibitors, since they simultaneously block several enzymes from the histone deacetylase family", he says. "And we still dont know enough about how the individual enzymes function".

Original publication: "Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimers disease", Nambirajan Govindarajan, Pooja Rao, Susanne Burkhardt, Farahnaz Sananbenesi, Oliver M. Schlter, Frank Bradke, Jianrong Lu, Andr Fischer, EMBO Molecular Medicine, online at: http://onlinelibrary.wiley.com/doi/10.1002/emmm.201201923/abstract

The German Center for Neurodegenerative Diseases (DZNE) investigates the causes of diseases of the nervous system and develops strategies for prevention, treatment and care. It is an institution of the Helmholtz Association of German Research Centres with sites in Berlin, Bonn, Dresden, Gttingen, Magdeburg, Munich, Rostock/Greifswald, Tbingen and Witten. The DZNE cooperates closely with universities, their clinics and other research facilities. Its cooperation partners in Gttingen are the Georg-August-University and the University Medical Center Gttingen. Website: http://www.dzne.de/en function fbs_click() {u=location.href;t=document.title;window.open('http://www.facebook.com/sharer.php?u='+encodeURIComponent(u)+'&t='+encodeURIComponent(t),'sharer','toolbar=0,status=0,width=626,height=436');return false;} html .fb_share_link { padding:2px 0 0 20px; height:16px; background:url(http://static.ak.facebook.com/images/share/facebook_share_icon.gif?6:26981) no-repeat top left; } Share on Facebook

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Molecular knock-out alleviates Alzheimers symptoms in mice