McMaster University, Hamilton, Ontario, Canada (D.Z., J.B., K.C., K.M., B.S., Y.L., G.H.G.)

Dalhousie University, Halifax, Nova Scotia, Canada (B.C.J.)

Jagiellonian University Medical College, Krakw, Poland (M.M.B.)

Iberoamerican Cochrane Centre Barcelona, Biomedical Research Institute San Pau (IIB Sant Pau), Barcelona, Spain (C.V., M.R., P.A.)

University of British Columbia, Vancouver, British Columbia, Canada (D.S.)

University of Toronto, Toronto, Ontario, Canada (A.A.)

Clinica Las Americas, Medellin, Colombia (A.M.Z.)

Chosun University, Gwangju, Republic of Korea (M.A.H.)

Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, the Netherlands (R.W.V.)

Institute of Science and Technology, Universidade Estadual Paulista, So Jos dos Campos, So Paulo, Brazil (R.E.)

Acknowledgment: The authors thank Thomasin Adams-Webber (Hospital for Sick Children) for her help designing our search strategy.

Disclosures: Dr. El Dib received a So Paulo Research Foundation (FAPESP) (2018/11205-6) scholarship and funding from the National Council for Scientific and Technological Development (CNPq) (CNPq 310953/2015-4) and the Faculty of Medicine, Dalhousie University. Authors not named here have disclosed no conflicts of interest. Disclosures can also be viewed at http://www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-0622.

Editors' Disclosures: Christine Laine, MD, MPH, Editor in Chief, reports that her spouse has stock options/holdings with Targeted Diagnostics and Therapeutics. Darren B. Taichman, MD, PhD, Executive Editor, reports that he has no financial relationships or interests to disclose. Cynthia D. Mulrow, MD, MSc, Senior Deputy Editor, reports that she has no relationships or interests to disclose. Jaya K. Rao, MD, MHS, Deputy Editor, reports that she has stock holdings/options in Eli Lilly and Pfizer. Catharine B. Stack, PhD, MS, Deputy Editor, Statistics, reports that she has stock holdings in Pfizer, Johnson & Johnson, and Colgate-Palmolive. Christina C. Wee, MD, MPH, Deputy Editor, reports employment with Beth Israel Deaconess Medical Center. Sankey V. Williams, MD, Deputy Editor, reports that he has no financial relationships or interests to disclose. Yu-Xiao Yang, MD, MSCE, Deputy Editor, reports that he has no financial relationships or interest to disclose.

Reproducible Research Statement:Study protocol: Available at PROSPERO (CRD42017074074). Statistical code and data set: Available from Dr. Johnston (e-mail, bjohnston@dal.ca).

Corresponding Author: Bradley C. Johnston, PhD, Department of Community Health and Epidemiology, Dalhousie University, Centre for Clinical Research, Room 404, 5790 University Avenue, Halifax, Nova Scotia B3H 1V7, Canada; e-mail, bjohnston@dal.ca.

Current Author Addresses: Ms. Zeraatkar, Ms. Bartoszko, nad Drs. Sadeghirad and Guyatt: Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada.

Dr. Johnston: Department of Community Health and Epidemiology, Dalhousie University, Centre for Clinical Research, Room 404, 5790 University Avenue, Halifax, Nova Scotia, B3H 1V7, Canada.

Dr. Cheung: 114 Loganberry Crescent, Toronto, Ontario M2H 3H1, Canada.

Dr. Bala: Jagiellonian University Medical College, 7 Kopernika Street, 31-034 Krakw, Poland.

Ms. Valli and Drs. Rabassa and Alonso-Coello: Iberoamerican Cochrane Centre, Instituto de Investigacin Biomdica de Sant Pau (IIB Sant Pau-CIBERESP), Carrer de Sant Antoni Maria Claret 167, Barcelona 08025, Spain.

Dr. Sit: University of British Columbia, 107-1165 West 13th Avenue, Vancouver, British Columbia V6H 1N4, Canada.

Mr. Milio: 592 Regal Place, Waterloo, Ontario N2V 2G3, Canada.

Dr. Agarwal: Department of Medicine, University of Toronto, Suite RFE 3-805, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.

Mr. Lee: 30 White Lodge Crescent, Richmond Hill, Ontario L4C 9A1, Canada.

Ms. Zea: Clinica Las Americas, Diagonal 75B N. 2A-80/140, Medellin, Colombia.

Dr. Han: Department of Preventive Medicine, College of Medicine, Chosun University, 309 Philmun-daero, Dong-gu, Gwangju 61452, Korea.

Dr. Vernooij: Department of Research, Netherlands Comprehensive Cancer Organisation, Godebaldkwartier 419, Utrecht 3511 DT, the Netherlands.

Dr. El Dib: Institute of Science and Technology, So Jos dos Campos, Avenida Engenheiro Francisco Jos Longo, 777, Jardim So Dimas, So Paulo 12245-000, Brazil.

Author Contributions: Conception and design: D. Zeraatkar, B.C. Johnston, M.M. Bala, P. Alonso-Coello, G.H. Guyatt, R. El Dib.

Analysis and interpretation of the data: D. Zeraatkar, B.C. Johnston, M.M. Bala, M. Rabassa, D. Sit, M.A. Han, P. Alonso-Coello, G.H. Guyatt, R. El Dib.

Drafting of the article: B.C. Johnston, R. El Dib.

Critical revision of the article for important intellectual content: D. Zeraatkar, B.C. Johnston, M.M. Bala, D. Sit, B. Sadeghirad, A.M. Zea, Y. Lee, M.A. Han, R.W.M. Vernooij, P. Alonso-Coello, G.H. Guyatt, R. El Dib.

Final approval of the article: D. Zeraatkar, B.C. Johnston, J. Bartoszko, K. Cheung, M.M. Bala, C. Valli, M. Rabassa, D. Sit, K. Milio, B. Sadeghirad, A. Agarwal, A.M. Zea, Y. Lee, M.A. Han, R.W.M. Vernooij, P. Alonso-Coello, G.H. Guyatt, R. El Dib.

Provision of study materials or patients: B.C. Johnston, R. El Dib.

Administrative, technical, or logistic support: D. Zeraatkar, B.C. Johnston, R. El Dib.

Collection and assembly of data: D. Zeraatkar, B.C. Johnston, J. Bartoszko, K. Cheung, M.M. Bala, C. Valli, M. Rabassa, D. Sit, K. Milio, B. Sadeghirad, A. Agarwal, A.M. Zea, Y. Lee, M. Han, R.W.M. Vernooij, R. El Dib.

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