John Bennett Jr. sat in a cushioned chair, stretched out his left arm and watched as Blanca Steffens filled a vial with his blood on a recent afternoon inside the clinical lab at AtlantiCare Physician Group Primary Care Plus in Northfield.
With just a little bit of that blood, researchers and geneticists with Geisinger Healths MyCode project will be able to tell Bennett whether his DNA carries genetic markers for certain diseases and health conditions.
The field of genomics has grown by leaps and bounds, and the testing once reserved for a select few has become available on a large scale. Dubbedprecision or predictive medicine, researchers hope to use genetic information to improve disease prevention, treatment and outcomes.
Rather than waiting for people to get sick, we can identify risks in people earlier and may prevent them from getting sick, said Andrew Faucett, director of policy and education in Geisingers Office of the Chief Scientific Officer. Its less expensive to keep someone healthy than it is to care for them sick.
Pennsylvania-based Geisinger launched MyCode in 2014 across its system of heath providers and hospitals, and now works with Regeneron Genetics Center. MyCode came to AtlantiCare locations and patients one year after it merged with Geisinger in 2015.
Faucett, also a professor atGeisinger Commonwealth School of Medicine, said theprogram has enrolled more than 150,000 patients, more than 10,000 of whom are from AtlantiCare.
Officials say the program intends to eventually include 250,000 enrollees. DNA has been analyzed so far for about 60 percent of participants as of Aug. 1, MyCode reports show.
Bennett, 55, of Somers Point, had read about the rise of genetic testing in medicine and had a family member who had it done years ago, so he jumped at the chance to participate in MyCode when the opportunity came, he said.
Anything to do to help with medical research and Im in, he said.
By collecting and analyzing genetic data from more than 150,000 people, Faucett said, researchers will be able to conduct comprehensive studies on how diseases can affect large populations.
For health providers and their patients, test results can provide information about a persons risk of developing certain disorders, such as cancers or cardiovascular conditions. Results can lead to discussions about medical care decisions with doctors and genetic counselors.
Scientists with the National Human Genome Research Institute completed sequencing of the human genome, or the complete human set of genetic instructions, in April 2003.
Experts can now look at someones DNA to see if their genetic coding has irregularities. A gene change can confirm if a person already has a disease, may develop a disease or is at risk of passing along a genetic disorder to his or her children.
Genetics can tell if a woman has a BRCA-1 or -2 gene mutation, which puts her at an increased risk for breast cancer, Faucett said. Now, she can use mammograms or preventative surgery to avoid cancer, or an advanced case.
Before genetic testing was more accessible to the general population, it was used primarily for patients at risk of rare conditions, such as Huntingtons disease, sickle cell disease, cystic fibrosis and others.
The MyCode program looks for variations in 76 genes associated with 27 clinically actionable disorders, or medical issues that can be prevented or managed better with knowledge of the gene mutation. The program does not test for Alzheimers disease or some rare conditions like those mentioned previously.
Faucett said preventive measures and sometimes treatment can be a one-size-fits-all approach, similar to how adults are generally recommended for colonoscopies starting at age 50, or women for mammograms starting at age 40 or 45.
But if someone has an identified gene mutation for colon or breast cancer, testing may be recommended at earlier ages. Faucett said genetic results for one person may also influence other family members to be more aware that they too may be more susceptible to these disorders.
Jessica Romanowski, research consenter for the MyCode program at AtlantiCare, explained to Bennett that it could take several months for his results. If there is a gene variation, Romanowski said, researchers will notify his primary care physician, who will schedule a follow-up with Bennett.
If they are gung-ho for research, (patients) are usually really supportive about participating, she said. Also, people want to know how it will benefit them. Some want to know about privacy and what will happen with their DNA. Patient privacy and confidentiality are very important to us.
A patients genetic information and results for the research end of things is identified only by a number, Faucett said. When variations are identified, researchers directly contact the patient's physician.
Under the program's current list of medically actionable diseases, Faucett said, about 3.5 percent of patients will get a call from their physicians with a positive, or gene-variation, result.
Because it is a research program, there is no cost to participate for patients who consent at any AtlantiCare Physician Group primary care location, the obstetrics and gynecology office or AtlantiCare Health Park, both in Egg Harbor Township. More specialty locations are being added, AtlantiCare officials said.
Faucett said much remains to be discovered in genomics, but Geisinger plans to use collected data to more precisely understand diseases, which may lead to solutions on how to better prevent or predict their occurrence in people.
Sometime in next five to 20 years, having your genes looked at will be part of normal care, he said. "Theres still a lot to learn how to use those results, but were learning. Its very exciting.
Follow this link:
MyCode genetics program brings predictive medicine to South Jersey - Press of Atlantic City
- Yes, But. The Annotated Atlantic. - November 7th, 2009 [November 7th, 2009]
- Health Insurance Benefit Costs by Region - November 8th, 2009 [November 8th, 2009]
- For an Operator, Please Press... - November 8th, 2009 [November 8th, 2009]
- Pollyanna With a Pen: Maine Governor Signs 18 New Health Care Bills into Law - November 8th, 2009 [November 8th, 2009]
- AMA Sounds the Alarm, Medicare Making Yet Another Attempt to Cut Reimbursement - November 8th, 2009 [November 8th, 2009]
- Mass Governor Asks Blue Cross to Keep Higher Employer Contribution - November 8th, 2009 [November 8th, 2009]
- Lifespan and Care New England Plan Monopoly (Again) - November 8th, 2009 [November 8th, 2009]
- Dirigo Health: Con Artists, Liars, and Thieves? - November 8th, 2009 [November 8th, 2009]
- New Orleans: Health Challenges - November 8th, 2009 [November 8th, 2009]
- August a Flurry of Activity - November 8th, 2009 [November 8th, 2009]
- Maine's Dirigo Health Savings One-Third of Original Estimate - November 8th, 2009 [November 8th, 2009]
- “Methodolatry”: My new favorite term for one of the shortcomings of evidence-based medicine - November 8th, 2009 [November 8th, 2009]
- Suzanne Somers’ Knockout: Dangerous misinformation about cancer (part 1) - November 8th, 2009 [November 8th, 2009]
- A science-based blog about GMO - November 8th, 2009 [November 8th, 2009]
- A Not-So-Split Decision - November 8th, 2009 [November 8th, 2009]
- Military Medicine in Iraq - November 8th, 2009 [November 8th, 2009]
- The effective wordsmithing of Amy Wallace - November 8th, 2009 [November 8th, 2009]
- A Science Lesson from a Homeopath and Behavioral Optometrist - November 8th, 2009 [November 8th, 2009]
- Join CFI in opposing funding mandates for quackery in health care reform - November 8th, 2009 [November 8th, 2009]
- Mainstreaming Science-Based Medicine: A Novel Approach - November 8th, 2009 [November 8th, 2009]
- Those who live in glass houses… - November 8th, 2009 [November 8th, 2009]
- J.B. Handley of the anti-vaccine group Generation Rescue: Misogynistic attacks on journalists who champion science - November 8th, 2009 [November 8th, 2009]
- When homeopaths attack medicine and physics - November 8th, 2009 [November 8th, 2009]
- The cancer screening kerfuffle erupts again: “Rethinking” screening for breast and prostate cancer - November 8th, 2009 [November 8th, 2009]
- All Medicines Are Poison! - November 8th, 2009 [November 8th, 2009]
- When Loud Wins: Will Your Tax Dollars Pay For Prayer? - November 8th, 2009 [November 8th, 2009]
- It’s All in Your Head - November 8th, 2009 [November 8th, 2009]
- The Skeptical O.B. joins the Science-Based Medicine crew - November 8th, 2009 [November 8th, 2009]
- The Tragic Death Toll of Homebirth - November 8th, 2009 [November 8th, 2009]
- What’s the right C-section rate? Higher than you think. - November 8th, 2009 [November 8th, 2009]
- Recombinant Human Antithrombin – Milking Nanny Goats for Big Bucks - December 13th, 2009 [December 13th, 2009]
- Does C-section increase the rate of neonatal death? - December 13th, 2009 [December 13th, 2009]
- Man in Coma 23 Years – Is He Really Conscious? - December 13th, 2009 [December 13th, 2009]
- Why Universal Hepatitis B Vaccination Isn’t Quite Universal - December 13th, 2009 [December 13th, 2009]
- Ontario naturopathic prescribing proposal is bad medicine - December 13th, 2009 [December 13th, 2009]
- Naturopaths and the anti-vaccine movement: Hijacking the law in service of pseudoscience - December 13th, 2009 [December 13th, 2009]
- The Institute for Science in Medicine enters the health care reform fray - December 13th, 2009 [December 13th, 2009]
- Neti pots – Ancient Ayurvedic Treatment Validated by Scientific Evidence - December 13th, 2009 [December 13th, 2009]
- Early Intervention for Autism - December 13th, 2009 [December 13th, 2009]
- A temporary reprieve from legislative madness - December 13th, 2009 [December 13th, 2009]
- A critique of the leading study of American homebirth - December 13th, 2009 [December 13th, 2009]
- Lose those holiday pounds - December 13th, 2009 [December 13th, 2009]
- Endocrine disruptors—the one true cause? - December 13th, 2009 [December 13th, 2009]
- Acupuncture for Chronic Prostatitis/Chronic Pelvic Pain Syndrome - December 13th, 2009 [December 13th, 2009]
- Evidence in Medicine: Experimental Studies - December 13th, 2009 [December 13th, 2009]
- Midwives and the assault on scientific evidence - December 13th, 2009 [December 13th, 2009]
- The Mammogram Post-Mortem - December 13th, 2009 [December 13th, 2009]
- An Influenza Recap: The End of the Second Wave - December 13th, 2009 [December 13th, 2009]
- The End of Chiropractic - December 13th, 2009 [December 13th, 2009]
- Cell phones and cancer again, or: Oh, no! My cell phone’s going to give me cancer! (revisited) - December 20th, 2009 [December 20th, 2009]
- Another wrinkle to the USPSTF mammogram guidelines kerfuffle: What about African-American women? - December 20th, 2009 [December 20th, 2009]
- Acupuncture, the P-Value Fallacy, and Honesty - December 20th, 2009 [December 20th, 2009]
- The One True Cause of All Disease - December 20th, 2009 [December 20th, 2009]
- Communicating with the Locked-In - December 20th, 2009 [December 20th, 2009]
- Are the benefits of breastfeeding oversold? - December 20th, 2009 [December 20th, 2009]
- Measles - December 20th, 2009 [December 20th, 2009]
- Radiation from medical imaging and cancer risk - December 21st, 2009 [December 21st, 2009]
- Multiple Sclerosis and Irrational Exuberance - December 21st, 2009 [December 21st, 2009]
- Medical Fun with Christmas Carols - December 22nd, 2009 [December 22nd, 2009]
- Lithium for ALS – Angioplasty for MS - December 23rd, 2009 [December 23rd, 2009]
- “Toxins”: the new evil humours - December 24th, 2009 [December 24th, 2009]
- 2009’s Top 5 Threats To Science In Medicine - December 24th, 2009 [December 24th, 2009]
- Buteyko Breathing Technique – Nothing to Hyperventilate About - December 26th, 2009 [December 26th, 2009]
- The Graston Technique – Inducing Microtrauma with Instruments - December 29th, 2009 [December 29th, 2009]
- The “pharma shill” gambit - December 29th, 2009 [December 29th, 2009]
- Ginkgo biloba – No Effect - December 30th, 2009 [December 30th, 2009]
- Oppose “Big Floss”; practice alternative dentistry - January 1st, 2010 [January 1st, 2010]
- Causation and Hill’s Criteria - January 3rd, 2010 [January 3rd, 2010]
- The life cycle of translational research - January 10th, 2010 [January 10th, 2010]
- The anti-vaccine movement strikes back against Dr. Paul Offit - January 10th, 2010 [January 10th, 2010]
- Osteoporosis Drugs: Good Medicine or Big Pharma Scam? - January 10th, 2010 [January 10th, 2010]
- Acupuncture for Hot Flashes - January 10th, 2010 [January 10th, 2010]
- The case for neonatal circumcision - January 10th, 2010 [January 10th, 2010]
- A victory for science-based medicine - January 10th, 2010 [January 10th, 2010]
- James Ray and testosterone replacement therapy (TRT) - January 10th, 2010 [January 10th, 2010]
- The Water Cure: Another Example of Self Deception and the “Lone Genius” - January 12th, 2010 [January 12th, 2010]
- Be careful what you wish for, Dr. Dossey, you just might get it - January 13th, 2010 [January 13th, 2010]
- You. You. Who are you calling a You You? - January 15th, 2010 [January 15th, 2010]
- The War on Salt - January 16th, 2010 [January 16th, 2010]
- Is breech vaginal delivery safe? - January 16th, 2010 [January 16th, 2010]