Geneticist Dr. Kat Arney explores the stories of two women one a scientist fascinated by dancing mice, the other a seamstress with a deadly family legacy who made significant contributions to our understanding of cancer as a disease driven by genetic changes. Yet while their work paved the way for lifesaving screening programs for families, it was used by some as justification for eugenics the idea of removing genetic defectives from the population.
Born in Minnesota in 1879, Maud Slye was a cancer pathologist who dedicated her career to studying patterns of cancer inheritance in more than 150,000 mice. But as well as being a dedicated scientist (as well as a part-time poet), she was also wedded to eugenic ideas, suggesting that If we had records for human beings comparable to those for mice, we could stamp out cancer in a generation. At present, we take no account at all of the laws of heredity in the making of human young. Do not worry about romance. Romance will take care of itself. But knowledge can be applied even to romance.
While her ideas were controversial, Slyes work earned her a gold medal from the American Medical Society in 1914 and from the American Radiological Association in 1922. She was also awarded the Ricketts Prize from the University of Chicago in 1915 and an honorary doctorate from Brown University in 1937. She was even nominated for a Nobel prize in 1923.
Over the decades since Slyes death in 1954, weve come to understand that the hereditary aspects of cancer susceptibility are much more complicated than she originally suggested, although her work was vital in establishing inherited gene variations as an essential thread of cancer research.
Running parallel to Slyes work in mice was the research carried out by Aldred Warthin, a doctor working at the University of Michigan in Ann Arbor. One day in 1895, a chance meeting between Warthin and a local seamstress, Pauline Gross, set the two of them off on a 25-year-long quest to understand why so many members of Paulines family had died from cancer at a young age.
Pauline spent years compiling detailed family histories, enabling Warthin to trace the pattern of inheritance through Family G, as it became known. Like Slye, Warthin was a fan of eugenic ideas, describing Paulines family as an example of progressive degenerative inheritance the running-out of a family line through the gradual development of an inferior stock.
He was also quoted as saying in a 1922 lecture: Today it is recognized that all men are not born equal. We are not equal so far as the value of our bodily cells is concerned.
Perhaps as a direct result of growing public concern about eugenics, Warthins work fell out of favor. Paulines detailed genealogy lay undisturbed in a closet in the university until the 1960s, when American doctor Henry Lynch and social worker Anne Krush rediscovered her work and continued extending and investigating Family G.
Nearly a decade on from that first meeting between Pauline and Warthin, researchers finally pinned down the underlying genetic cause of this deadly legacy: an inherited variant of the MSH2 gene, which normally repairs mismatched DNA strands. Today, members of Family G and others around the world carrying dangerous variants in mismatch repair genes can undergo genetic testing, with a range of preventative and screening options available.
The story of Pauline and Family G, and the impact that their genetic legacy has had on the family down the generations, is beautifully told in the book Daughter of Family G, a memoir by Ami McKay.
Full transcript, links and references available online atGeneticsUnzipped.com
Genetics Unzippedis the podcast from the UKGenetics Society,presented by award-winning science communicator and biologistKat Arneyand produced byFirst Create the Media.Follow Kat on Twitter@Kat_Arney,Genetics Unzipped@geneticsunzip,and the Genetics Society at@GenSocUK
Listen to Genetics Unzipped onApple Podcasts(iTunes)Google Play,Spotify,orwherever you get your podcasts
See the rest here:
- Anton Chaitkin: the British Monarchy & Euthanasia - November 8th, 2009 [November 8th, 2009]
- Rate the The Mental Hygiene Society - Yale University connection - November 8th, 2009 [November 8th, 2009]
- Len Horowitz files pandemic charges against Rockefeller - November 8th, 2009 [November 8th, 2009]
- Judge Napolitano on Forced Vaccinations in Massachusetts - November 8th, 2009 [November 8th, 2009]
- Joseph Moshe (MOSSAD Microbiologist): “Swine flu vaccine is bioweapon” - November 8th, 2009 [November 8th, 2009]
- Canadian study that suggests seasonal flu shots raise a person's risk of catching swine flu - November 8th, 2009 [November 8th, 2009]
- Doctor Admits Vaccine Is More Deadly Than Swine Flu Itself & Will Not Give It To His Kids - November 8th, 2009 [November 8th, 2009]
- Ineffectiveness And Dangers Of Flu Shots - November 8th, 2009 [November 8th, 2009]
- Maafa 21 - November 8th, 2009 [November 8th, 2009]
- Doctors Concerned FluMist Vaccine Could Spread Live H1N1 Virus - November 8th, 2009 [November 8th, 2009]
- Martial Law Soon - November 8th, 2009 [November 8th, 2009]
- Humanity's Greatest Challenge - Fear or Love - November 8th, 2009 [November 8th, 2009]
- Does the Vaccine Matter? - November 8th, 2009 [November 8th, 2009]
- Ten questions about flu vaccines that doctors and health authorities refuse to answer - November 8th, 2009 [November 8th, 2009]
- Swear NO Oaths (UNDERSTANDING JURISDICTION) - November 8th, 2009 [November 8th, 2009]
- WARNING! Goodbye U.S Sovereignty... Hello One World Government ! - November 8th, 2009 [November 8th, 2009]
- Glenn Beck interviews Lord Monckton on the Soviet style takeover of America by the NWO & BHO - November 8th, 2009 [November 8th, 2009]
- TAVISTOCK - THE BEST KEPT SECRET IN AMERICA - November 8th, 2009 [November 8th, 2009]
- Become a Free Man { SUI JURIS } - November 8th, 2009 [November 8th, 2009]
- The Income Tax Trial of the Century - November 8th, 2009 [November 8th, 2009]
- Gary Null Speaking Out Against vaccines at the NYS Assembly Hearing | 10-13-2009 - November 8th, 2009 [November 8th, 2009]
- WHO memos 1972 explains how to turn vaccines into a means of killing - November 8th, 2009 [November 8th, 2009]
- The Swine Flu (aka 'H1N1) That's Not A Flu At All - November 8th, 2009 [November 8th, 2009]
- Lord Christopher Monchton, 3rd Viscount Monckton of Brenchley, answers critics of his claim that Obama intends to cede U.S. sovereignty - November 8th, 2009 [November 8th, 2009]
- Swine Flu Government Data Scam Government using fraud to generate flu hysteria - November 8th, 2009 [November 8th, 2009]
- The Strecker Memorandum video - November 8th, 2009 [November 8th, 2009]
- United States Patent 4,647,773 Gallo -Continuous production of retroviruses - November 8th, 2009 [November 8th, 2009]
- DEPARTMENT OF DEFENSE APPROPRIATIONS FOR 1970 : The funding of the Bio-terrorism AIDS virus - November 8th, 2009 [November 8th, 2009]
- The Merchants of AIDS - full article - November 8th, 2009 [November 8th, 2009]
- Another Tool of Eugenics: Fluoride - November 8th, 2009 [November 8th, 2009]
- 1988: Dr. Jonathan Mann : Killed in Plane Crash - November 8th, 2009 [November 8th, 2009]
- Boyd Graves: Interview with Alex Jones - November 8th, 2009 [November 8th, 2009]
- Boyd Graves: Letter to Ninth Circuit Court - November 8th, 2009 [November 8th, 2009]
- Gallo and Litton Bionetics: Creators of Aids - November 8th, 2009 [November 8th, 2009]
- This site is being developed - November 8th, 2009 [November 8th, 2009]
- 2002: Eleven microbiologists mysteriously dead over the span of just five months - November 8th, 2009 [November 8th, 2009]
- Kissinger, Eugenics and Nazis - November 8th, 2009 [November 8th, 2009]
- July 27, 1990: Aids is man-made - By William Cooper [Killed by Law enforcement in 2001] - November 8th, 2009 [November 8th, 2009]
- The Merchants of aids - November 8th, 2009 [November 8th, 2009]
- Why we should not trust the health market. - November 8th, 2009 [November 8th, 2009]
- Dr. David James preview - conscious media network - November 8th, 2009 [November 8th, 2009]
- AIDS HIV BAYER CORPORATION HEMOPHELIA TAINTED BLOOD SUPPLY - November 8th, 2009 [November 8th, 2009]
- Ugandians not dying fast enough. International Eugenists (Aids experts) want them to engage in casual sex - November 8th, 2009 [November 8th, 2009]
- Proof that AIDS was engineered to kill primarily blacks - November 8th, 2009 [November 8th, 2009]
- In lies we Trust. The history of American Bioterrorism - November 8th, 2009 [November 8th, 2009]
- Dallas: A possible Aids Cure? - November 8th, 2009 [November 8th, 2009]
- Glutathione Accelerator - Any Good? - November 8th, 2009 [November 8th, 2009]
- Dr. Boyd Ed Graves International AIDS activist dies age 57 - November 8th, 2009 [November 8th, 2009]
- Genocide in Progress with novel flu virus. - November 8th, 2009 [November 8th, 2009]
- Genocide in Progress with new flu virus- CDC is suspect - November 8th, 2009 [November 8th, 2009]
- Vaccines: The Bargain Basement Technology of the 20th Century - December 13th, 2009 [December 13th, 2009]
- Anthrax - as American as Apple Pie. Eustace Mullins - December 13th, 2009 [December 13th, 2009]
- Swine flu: Some pregnant women shunning H1N1 vaccine - December 13th, 2009 [December 13th, 2009]
- CFR lies to get You to take the Shot - December 13th, 2009 [December 13th, 2009]
- US spraying Ukraine?? - December 13th, 2009 [December 13th, 2009]
- Eustace Mullins: Murder By Injection - December 13th, 2009 [December 13th, 2009]
- Microbiologist nabbed by FBI after warning us that vaccine is a bioweapon deployment - December 13th, 2009 [December 13th, 2009]
- Airplanes sprayed mysterious substance over Ukraine days before pneumonic plague outbreak - December 13th, 2009 [December 13th, 2009]
- NIH Whistleblower Alexander S. Jones: Deadly Flu Spreads Across Ukraine - December 13th, 2009 [December 13th, 2009]
- RBD Change D225G in Ukraine Lungs Raises Concerns - December 13th, 2009 [December 13th, 2009]
- Young Boy in Agony After AH1N1 Nasal Flu Mist - December 13th, 2009 [December 13th, 2009]
- Unconfirmed Reports of Large Numbers of Deaths from the Vaccine in the Ukraine - December 13th, 2009 [December 13th, 2009]
- Vaccinations are Causing Impaired Blood Flow (Ischemia), Chronic Illness, Disease and Death for us All - December 13th, 2009 [December 13th, 2009]
- British scientists suspect that swine flu virus has mutated in Ukraine. - December 13th, 2009 [December 13th, 2009]
- Vaccination: Federal Health Agencies Continue to Deceive Americans - December 13th, 2009 [December 13th, 2009]
- Ukraine plagues and now heavy supply and personnel movement in and out of US Deep Underground Military Bases (DUMBs) - December 13th, 2009 [December 13th, 2009]
- College Students Getting Smarter, Shunning H1N1 Vaccine - December 13th, 2009 [December 13th, 2009]
- Deeper down the rabbit hole - December 13th, 2009 [December 13th, 2009]
- Ukraine Pneumonic Plague Research Nov 2009 - December 13th, 2009 [December 13th, 2009]
- Keiser on 'Tsunami alert': Dubai debt crisis awakes storm? - December 13th, 2009 [December 13th, 2009]
- Christopher Story - EU Corruption - December 13th, 2009 [December 13th, 2009]
- John Harris - Undermining Democracy - December 13th, 2009 [December 13th, 2009]
- The first case of HIV/AIDS cure and no mention in the media. Why? - December 13th, 2009 [December 13th, 2009]
- What is AIDS? - January 7th, 2010 [January 7th, 2010]
- Europe to Investigate the UN Over “Pandemic” Scam - February 13th, 2010 [February 13th, 2010]
- Nuke @ Olympics ????? - February 13th, 2010 [February 13th, 2010]
- Intelligent Anti-Fluoride Statement - Dr. J. William Hirzy - February 24th, 2010 [February 24th, 2010]
- Testimony [4-9] Fluoride's Definitive Medical Indictment - February 24th, 2010 [February 24th, 2010]
- History Lesson - March 10th, 2010 [March 10th, 2010]
- As the Bank System fails so will society - March 13th, 2010 [March 13th, 2010]