What is precision medicine?

Precision medicine, also referred to as personalized medicine, is the opposite of a one-treatment-fits-all model, instead tailoring disease prevention, diagnosis and treatment based on a persons own genes or proteins as well as potentially their environment and lifestyle. According to the Precision Medicine Market Report 2022-2023, the increase in scope of application of precision medicine is expected to propel market growth as the leading precision medicine disease focus, oncology, is joined by immunology, central nervous system (CNS), respiratory and other diseases.

Specific to cancer, over the pastseveral decades, researchers, scientists and therapeutic manufacturers in oncology have significantlyimproved treatment outcomes by embracing this precision medicine approach, with some advancements even called revolutionary. Today, cancer patients often undergo molecular tests and genetic profiling to align the physicians treatment selection with the drug most likely to improve a particular patients prognosis. This recognizes that no two cancers are the same, no two patients are the same, and even within established categories, such as breast cancer, different therapeutics will benefit different individuals.

Advances made in oncology are setting a precedent for whats possible in personalized medicine scenarios in other areas and powerfully impacting what the future of tailored care will mean.

Industry visionaries focusing on other disease states and optimizing treatment outcomes are applying the learnings from cancer precision medicine to their own specialties. Rheumatology is one such field. As the prevalence of autoimmune conditions, currently estimated to affect about 3 percent of the US population, increases, it becomes more critical to address individual cases with effective treatments. Like cancer, the underlying factors and disease progression for autoimmune conditions such as lupus, rheumatoid arthritis (RA) and Sjogrens Syndrome vary among those afflicted, and so should the treatment approach.

What makes the promise of precision medicine so appealing to both physicians and patients with autoimmune conditions is that currently, especially for RA, successful treatment response rates to existing therapeutics vary widely and this may be due to physicians taking the one-medication-fits-all approach with first-line therapeutics.

An increase in treatment options for RA has emerged in recent years, particularly when it comesto the development of dozens oftargetedimmunomodulators (TIMs)across five main types of mechanisms of action. However, despite the growing number of TIMs approved to treat RA, drug selection remains a process driven by empirical physician judgment and influenced by insurers drug formulary rules. Phase 3 trials for virtually all RA drugs demonstrate a treatment ceiling whereby approximately 40 percent of patients do not achieve minimal response, and as many as 80 percent do not achieve a major treatment response.

By utilizing a more personalized approach to autoimmune conditions, starting with an accurate diagnosis, physicians can better inform patients and prescribe treatments that hold the most promise for individual symptom relief and in some cases, have the potential to halt disease progression.

Emerging, innovative diagnostic technology promises to change the current trial and errorof assigning treatment protocols for RA, fostering a breakthrough of the treatment response ceiling with drugs that are currently available. Taking a page from oncology, new molecular tests are now a viable option for linking individual patients to the targeted therapy that has the greatest potential for personalized clinical response.

Specific to RA, there are approximately 1.5 million people with the condition in the United States with about 120,000 new diagnoses each year. Targeted biologic therapies in RA are among the largest categories of therapeutic spending in the United States. So, while treatment options are widespread, the key to unlocking the potential of the most effective RA treatment for those affected is in molecular characterization of the synovium the portion of the joints where the drivers of RA damage/progression are present.

These tests, through synovial biopsies, will provide physicians a new approach to the traditional standard of care model. In addition to the obvious benefit of providing more targeted, effective solutions to patients, the tests will also save them time by mitigating repeated trial and error attempts with targeted biologics that leave RA patients without symptom relief while an effective drug is identified. As an example, a study published in Nature Medicine on May 19, 2022, demonstrated that molecular profiling of synovial joint tissue might greatly impact whether certain drug treatments would be effective in treating RA patients.

Furthermore, there is an additional cost benefit: personalized medicine in RA has the potential to reduce billions of dollars spent annually on drugs that do not yield adequate disease control.

Taking a lesson from other disease areas, the potential for innovative diagnostics and a precision medicine approach in treating a variety of autoimmune diseases, including RA, is becoming more and more of a reality and will pave a path to more positive patient outcomes.

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Unlocking the Power of Precision Medicine the Rheumatology Example - Technology Networks

A new study from Weill Cornell Medicine investigators shows that cultural values and social support may influence a caregivers burden, self-efficacy and depressive symptoms. These findings suggest interventions aimed at buffering the negative effects of care-related stress should reinforce the importance of social connections.

In a study reported in the July 2022 issue of the Journals of Gerontology: Series B, a team led by first author Dr. Francesca Falzarano, a postdoctoral fellow, and senior author Dr. Sara J. Czaja, professor of gerontology in medicine in the Division of Geriatrics and Palliative Medicine at Weill Cornell Medicine, examined racial and ethnic differences in familism -- a cultural value that centers around a sense of collectivism in the family -- and social support to better understand cross-cultural differences in caregiving outcomes.

Familism is a cultural justification to provide care, and there are three factors: family obligations, or how does your culture and your family structure influence your feelings of obligation to provide care? Perceived support, or what's a persons perception of support that they receive from their family. And then family as referents, which is being exposed to a family member providing care and using that as a model, Dr. Falzarano said.

The aging population, as well as the caregiving population, are becoming much more ethnically diverse in the United States, Dr. Czaja said. We know that there are cultural differences in ideas about caregiving and it's important to understand those differences in order to develop efficacious interventions.

The Weill Cornell researchers hypothesized that Hispanic and Black people would exhibit higher levels of familism and that familism would act as a buffer and mitigate care-related strain in these caregivers.

The literature is actually very mixed on whether familism is helpful, Dr. Falzarano said. But we thought individuals who might be high in familism -- particularly members of the Hispanic and Black groups -- might have more expansive social support networks, whether it be kin and non-kin relationships, that can aid in caregiving and lead to more positive caregiving appraisals, such as higher self-efficacy and reduced depression.

Their team collected data from 243 caregivers whose loved ones had Alzheimers disease or other related dementias (ADRD) -- a population of caregivers that tend to have higher degrees of feeling burdened and stressed. The caregivers, who ranged in age from 20 to 95, lived in the greater Miami region and were participants in the Caring for the Caregiver Network study, a study funded by the National Institutes of Health, which examined a culturally-tailored, technology-based psychosocial intervention.

This intervention was primarily delivered virtually and included caregiver skill building and support sessions, support groups, and enhanced access to resources, Dr. Czaja said.

Of the 243 participants, 55 were Black, 79 were white, and 109 were Hispanic. Researchers found that the Black and Hispanic participants reported higher familism compared with white participants. Black participants also reported higher levels of social support, which in turn predicted lower burden and depressive symptoms when compared with white participants.

Our hypotheses were largely maintained, which really highlights the criticality of this topic, Dr. Czaja said. Its vital for caregivers to know theyre not alone and they should not feel bad about needing or seeking support. And while family is important, we must also enhance support for individuals who do not have family. We must also define the term family broadly.

The team, which included Dr. Jerad Moxley, instructor of psychology in medicine, and Dr. Karl Pillemer, professor of gerontology in medicine at Weill Cornell Medicine and the Hazel E. Reed Professor in the Department of Human Development at Cornell University, also did an exploratory analysis with Hispanic participant acculturation, or assimilation to a new culture.

We didnt know what we were going to find, but our results showed that the greater number of years a Hispanic person spends in the United States, the lower they score on the familism scale, Dr. Falzarano said.

Since Hispanic is an umbrella term representative of many different cultures, values and belief systems, the Weill Cornell researchers are collaborating with Dr. Andrs Losada Baltar, a professor at Universidad Rey Juan Carlos in Madrid, to see if their model replicates in a Spanish sample of caregivers.

We will compare our Hispanic subsample with a subsample of dementia caregivers from Spain, Dr. Falzarano said. And so, we're continuing to further parse apart these different groups, their cultural beliefs and how that impacts their caregiving outcomes.

In the future, the Weill Cornell researchers also hope to expand their research to first-generation caregivers and members of other racial or ethnic groups.

Overall, our findings show that a one-size-fits-all approach to interventions is not efficacious, Dr. Czaja said.

Many Weill Cornell Medicine physicians and scientists maintain relationships and collaborate with external organizations to foster scientific innovation and provide expert guidance. The institution makes these disclosurespublic to ensure transparency. For this information, see profile for Dr. Sara Czaja.

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Family and Social Support May Influence Caregiver Stress and Depression - Weill Cornell Medicine Newsroom

A thirst for knowledge, love of teaching, and affinity for adventure guided the career of Robert Noiva a scientist and educator critical to the foundation and future of OUWB.

Now, Noiva, Ph.D., is slowing down a little, at least after retiring from OUWB.

For the school, Noivas most recent titles were associate dean for Graduate Studies and Community Integration, and associate professor, Department of Foundational Medical Studies.

Now, Noiva plans to focus on his titles of retiree, Washingtonian, husband, father, and especially, grandfather.

I wont miss budget meetings, annual performance evaluations, and all of that paperwork stuff, he said. But I will miss the interaction with the studentsthats whats fun and inspiring.

Colleagues likeJudith Venuti, Ph.D., professor emeritus, OUWB. said his commitment to education has always been evident in his work, and will continue to show as OUWB evolves.

Bob was instrumental in helping OUWB get off the ground and was a strong leader with great organizational skills and vast expertise in medical education, said Venuti.

Duane Mezwa, M.D., Stephan Sharf Dean, OUWB, recently shared similar sentiments about Noiva.

Bob Noiva brought a wealth of expertise and knowledge in the field of medical education when he arrived at our new medical school more than 10 years ago, said Mezwa. We are grateful that he accepted the challenge and excelled at shaping medical education at OUWB.

Strong role models as teachers

Noiva grew up in Hartford, Connecticut, as one of five children in his family.

He excelled in math and science and enjoyed problem-solving. Noiva also understood from a young age the importance of good mentors.

When youre a student and in a classroom, I think you can identify when theres a genuine sense of commitment by the instructorthat they care about you learning, he said. I think thats one of the things that probably motivates many of us that have gotten into academicswe had strong role models as teachers.

Noiva would go on to attend Michigan State University and earn a bachelors in biochemistry.

It was really appealing to me to be doing something in chemistry related to human health, he said.

Between his sophomore and junior years at MSU, Noiva began dating a classmate named Nancy. Post-graduation, the couple married and relocated to Hartford. Nancy worked at Oak Hill School for the Blind and Robert worked in the pathology department at Hartford Hospital.

As in high school, Noiva said he had great mentors who encouraged him to go further specifically to get a Ph.D.

I told them that I didnt know about graduate schools or how to even do that, he said.

His mentors helped him identify programs, including one at Creighton University. He wrote the school a two-page letter introducing himself, highlighting his experience, talking about his plans, and asking for an application.

They called me and said Can you be out here in two weeks? he said. Thats how I ended up in Omaha.

The willingness to take on the challenge was very similar to how he ended up at OUWB.

When I have an opportunity, I go for it, he said. Weve always been willing to do things that are a little adventuresome.

Its about being empathic

Noiva did his postdoc in Houston, Texas, at M.D. Anderson Cancer Center, for three years.

By then, in addition to his experience in clinical settings, he had built up a solid teaching portfolio.

Much of it happened at Creighton, where graduate students were required to serve as teaching assistants. He also tutored for a summer program at Creighton for remediating medical students from across the U.S.

(Those experiences) really helped me to be a good teacher, he said.

After M.D. Anderson, Noiva took his first faculty position at University of South Dakota Sanford School of Medicine a week after the Noivas daughter, Jennifer, was born.

At South Dakota, he continued refining and improving his skills as an educator. Senior faculty were required to mentor anyone who took on a new teaching role.

Equally vital, he said, was a never-ending quest to learn, adapt, and improve through professional development. And he always drew on his own experiences as a student.

Its about being empathic, he said. That if you know what you wanted as a student and perhaps sometimes didnt get, you think to yourself Im not going to do that to these students.

Noiva spent 18 years in South Dakota.

A different medical school

In the early 2010s, Noiva decided to once again take a chance this time on Lake Erie College of Osteopathic Medicine, a medical school in Erie, Pennsylvania. He was there for a year before the dream opportunity to come to Oakland University William Beaumont School of Medicine.

I dont think youre given many opportunities to start with a blank slate and do what you want to do, said Noiva.

But thats exactly what he got when Noiva decided to join the team launching OUWB.

He worked with OUWB Founding Dean Robert Folberg, M.D., and others, to create the schools blueprint a plan that very much relied on getting the right people in place.

They had a great idea of making this a medical school that was going to be different, he said. Having a faculty that was really going to be focused on student successwas attractive to a number of people.

Noiva said things really started to get exciting as new educators joined OUWB. He recruited Venuti, whom he had worked with at M.D. Anderson.

Nelia Afonso, M.D., assistant dean for Community Integration & Outreach and professor, Department of Foundational Medical Studies, joined the team.

Others did, too, such as David Thomas, Ph.D., who now serves as associate dean for Preclinical Education, along with Barbara Joyce, Ph.D., Rick Sabina, Ph.D., and William Forbes, D.D.S.

Noiva credits Christina Grabowski, Ph.D., former assistant dean of Admissions, for recruiting OUWBs first class of 50 that had an entrepreneurial spirit and sought to embody what the school was all about.

Noiva said he regretted not having the opportunity to thank the many other colleagues at OU that helped make OUWB a success, including dedicated educators that emphasized a student-centered approach in their teaching; key staff and faculty important in creating and shaping the OUWB curriculum; outstanding clinician educators; and those who demonstrated the importance to addressing health and wellness disparities in the community.

It wasnt the administration that made this work, he said. It was faculty and staff driven.

In reflection, Noiva called his time at OUWB a wonderful opportunity.

But now hes onto new wonderful opportunities and adventures.

During a recent session called Five Easy Lessons I Learned to Improve My Teaching, Noiva explained that he and Nancy are moving to a Seattle suburb.

He talked about spending more time doing the little things simply reading for pleasure or going to baseball games.

Then there are the bigger things spending more time with his daughter.

And then theres perhaps the biggest thing the one thing that made him emotional in talking about retirement spending time with his grandson, Caspian.

Whenever he sees me, he smiles, said Noiva, his voice cracking. So thats all.

For more information, contact Andrew Dietderich, marketing writer, OUWB, at adietderich@oakland.edu.

To request an interview, visit the OUWB Communications & Marketingwebpage.

NOTICE: Except where otherwise noted, all articles are published under aCreative Commons Attribution 3.0 license. You are free to copy, distribute, adapt, transmit, or make commercial use of this work as long as you attribute Oakland University William Beaumont School of Medicine as the original creator and include a link to this article.

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Noiva retires from Oakland University William Beaumont School of Medicine - News at OU

At the age 18 while hooked up to monitors in a hospital bed and believing he was going to die of a severe allergic reaction, Bernie Ranchero, MD, MBA, confessed to his pastor he struggled with his sexuality and that he was gay. Growing up in a conservative religious family during the 80s and90s while the AIDs epidemic was shaping public perceptions of homosexuality had affected how he saw himself and made him want to hide who he was. It would be many years after his deathbed confession for the physician to fully come to terms with his identity and to become accepting of his own self-worth.

When I was 31 years old, Dr. Ranchero said, I reconciled my faith and sexuality, and I came to the realization that I was not an abomination. I had to overcome my own bias I had toward myself.

Overcoming his personal struggles and hearing of his patients medical experiences in rural Illinois drives him to address the challenges those in the LGBTQIA+ community face. Dr. Ranchero a Carle Illinois College of Medicine clinical assistant professor, the Coles County Public Health Department medical director and a practicing family medicine physician presented Killing me softly. Discrimination and inequality in medicine in a recent education series on gender inclusive care.

Dr. Ranchero discussed how shame and fear of discrimination can be barriers to care among the LGBTQIA+ community, especially for those in areas lacking diversity. Being different can mean being treated differently, even in the healthcare setting.

"Ive had numerous discussions with patients about this. They dont even want to call an ambulance because they fear being judged. They're talking to a nurse, to a tech, or provider and they're called by that dead name. When we call them the dead name their old name that person has to come out all over again, Dr. Ranchero said. They have to experience that shame again.

When treating someone whose experienced discrimination, you can gauge the severity almost as you would with physical burns.

Have they experienced a superficial burn or is it a fourth degree burn and they don't even know the limb is burnt off because theyre so hurt? Dr. Ranchero said, We need to be aware of where that patient is and acknowledge that.

Dr. Ranchero stressed having a climate of dignity and respect, so patients can be themselves.

Set the tone for your clinic, for your practice and your colleagues. What kind of environment are you going to have the first time you meet someone you're unsure of their gender or you don't know their sexual identity?Reassuring the patient theyre in a safe space is a start. But making a connection with the patient will help establish trust. Dr. Ranchero recommends asking how they wish to be addressed and if they feel comfortable sharing their story.

And rather than assuming a transgender pediatric patient isnt capable of making important healthcare decisions, Dr. Ranchero said, We as providers need to ask, Tell me about your journey, about your history. From that, we can gather their insight, their judgment and thought processes.

RN Program Manager of Carle Faith Community Health, Gregory Scott, MS, RN, recognizes how important it is to connect with patients and try to understand their experience with a mindset of whole-person care mind/body/spirit.

We get so focused on the clock Ive got 15 minutes with you thats treating the clock and not the person, Scott said. Take a moment to listen and honestly hear what theyre dealing with.

Dr. Ranchero noted that a common challenge for providers is helping to motivate LGBTQIA+ patients seemingly indifferent to their health. In some cases, this stems from the patients diminished sense of self-worth.

They don't see that their life is worth it and that's where we must begin, Dr. Ranchero said. We say, No, you're a person and youre worth the time and effort. I care about you and your health.

This was something even Dr. Ranchero needed to hear to combat his own self-loathing and feelings of worthlessness.

I stand up for them because someone needed to stand up for me and say, Bernie, you're worthy. You're worthy of medicine, you're worthy of good care and you're worthy of love. And we as providers need to share that compassion for our LGBTQIA patients.

Though even providers who want to be compassionate, fair and respectful can be influenced by unconscious biases.

Our unconscious thought might go against what we know and verbalize. Inside, bias still plays a role, Dr. Ranchero said. But we need to meet patients where they are and not ask them to come to our values and culture.

Scott has noticed how bias can affect patient outcomes and care.

When patients sense our bias, they may never come back, Scott said. We see this escalation of chronic conditions that arent managed well, and patients who dont receive regular annual visits because at some point, they endured a negative experience or trauma.

Giving patients the care they need and treating them with respect is a duty Dr. Ranchero holds sacred.

The most defining moments in my life are when Ive received healing be it physical, psychological, emotional, cognitive, or spiritual. Those are powerful moments. As healers, were called to be conduits, or pathways, for others to receive healing.

Categories: Culture of Quality, Redefining Healthcare, Community

Tags: gender, inclusivity, physicians

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Worthy of medicine, worthy of good care and worthy of love | Carle.org - Carle Health

Sixers managing partner Joshua Harris and his wife Marjorie have announced a new initiative where they will invest $1 million in companies funded by the Penn Medicine-Wharton Fund for Health. The goal of this undertaking is to improve the livelihood of Philadelphians while focusing on the social determinants of health.

More info from the Sixers is available below:

Philanthropists Josh Harris, managing partner of the Philadelphia 76ers, and his wife, Marjorie Harris, plan to invest $1 million in companies funded by the Penn Medicine Wharton Fund for Health, a collaboration between Penn Medicine and the Wharton Social Impact Initiative of the University of Pennsylvanias Wharton School that invests in early-stage businesses working to improve the social determinants of health of economically disadvantaged Philadelphians. The initiative was first announced in August 2021, with initial plans for a $5 million investment over the following three years.

We are thrilled to continue collaborating with Penn Medicine through the Fund for Health to improve the health of Philadelphia communities, particularly underserved communities that may not have access to the same resources, said Josh Harris, Managing Partner of the Philadelphia 76ers. There are so many factors that contribute to overall health and well-being the goal of this initiative is to invest in innovative companies that are directly addressing the issues that lead to health inequities and support them as they scale.

Social determinants of health include issues such as food insecurity and lack of access to quality healthcare or stable housing, which affect a wide range of health risks and outcomes. Philadelphia County is among the hardest hit cities in the nation by the toll of these disparities, with more than 25 percent of residents living in poverty, 20 percent coping with food insecurity, and nearly 15 percent of its residents uninsured, according to Penn Medicines 2019 Community Health Needs Assessment report.

No ones zip code should determine whether they're able to live a healthy life, but tackling longstanding, systemic problems requires a creative approach and diverse expertise two factors which were at the foundation of our creation of the Fund for Health, said University of Pennsylvania Health System CEO Kevin B. Mahoney. We can make an even greater impact when like-minded collaborators who share this mission also decide, following their own diligence, to make follow-on investments. I am thrilled Josh and Marjorie Harris will be joining forces with us in this way to propel our vision to improve the social determinants of health in our city.

The four companies who this far have received funding are Kinvolved, Lula, Uptrust and RecoveryLink:

Kinvolved, a leader in developing communications software to reduce absenteeism inunderserved school districts, which has subsequently been acquired by PowerSchool, acloud-based K-12 educational software provider.

Lula, which provides a platform and support for small, often family-owned conveniencestories pharmacies and other brick-and-mortar stores to deliver to customers via appslike DoorDash, Grubhub, and Uber EATS.

Uptrust, a customer relationship management tool that helps keep people out of thecriminal justice system by avoiding unnecessary technical violations, like missing courtdates or probation appointments.

RecoveryLink, a telehealth and electronic recovery records platform that improves theavailability and delivery of recovery support services to people experiencing substanceuse and mental health disorders.

This continues a pre-existing relationship between the Harris' philanthropy efforts and and Penn Medicine that previously helped deploy COVID-19 antibody testing to Philadelphia doctors and nurses early in the pandemic.

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Josh and Marjorie Harris announce new funding initiative with Penn Medicine - PhillyVoice.com

Taya Glotzer, M.D., FACC, FHRS, honored at the New Jersey Heart Ball on June 10

Taya Glotzer, M.D., FACC, FHRS, has been named the American Heart Associations (AHA) 2022 Researcher of the Year. The award is given to a researcher who is performing cutting-edge research in the field of heart disease and/or stroke.

Research is a cornerstone of the American Heart Association and acknowledging individuals who are making advancements is very important to us, said Peter Cary, executive director for the New Jersey region with the AHA. Dr. Glotzer and her work deserve recognition, and we are so thankful for her dedication to help people live longer, healthier lives.

Dr. Glotzer, who is a professor of medicine at the Hackensack Meridian School of Medicine and the director of Cardiac Research at Hackensack University Medical Center, received the award at the American Heart Association's annual gala, the New Jersey Heart Ball, on June 10.

Dr. Glotzer is one of our supremely talented researcher-physicians, said Robert C. Garrett, CEO of Hackensack Meridian Health. We applaud her achievement.

We are so proud of Dr. Glotzers contributions to the great science and innovation driven by our network, said Ihor Sawczuk, M.D., FACS, president of Academics, Research and Innovation for Hackensack Meridian Health. Our program to promote clinicians engaging in research continues to pay dividends for our patients - and national organizations are noticing.

Widely published and invited regularly by organizations including the American College of Cardiology, American Heart Association, Heart Rhythm Society, and the European Society of Cardiology to present nationally and internationally, Dr. Glotzer has had a longstanding interest in the prevention of stroke, and in investigating the relationship between atrial fibrillation (AF) and stroke.

She published one of the first papers identifying the association of cardiac implanted device detected AF with poor clinical outcomes; stroke and death, in 2003. Dr. Glotzer was the primary investigator of a landmark trial (TRENDS), which showed that a device detected AF longer than 5.5 hours in the recent 30 days doubles the risk of stroke. She was part of the writing group for the Heart Rhythm Society Expert Consensus Statement on Remote Monitoring, and for the European Heart Rhythm Association consensus document on Device Detected Subclinical AF.

In response to the pandemic, Hackensack University Medical Center launched a COVID-specific cardiology research group, of which Dr. Glotzer is a member. The group is collaborating to shed light on COVIDs effect on the heart and blood vessels. In this capacity, Dr. Glotzer found abnormalities on admission EKGs that predicted poor outcomes in patients hospitalized with COVID-19. She presented her findings at the Heart Rhythm Societys 2021 Annual Scientific Sessions.

Dr. Glotzer received her medical degree from the New York University School of Medicine in 1987, and did her residency, cardiology fellowship, and electrophysiology fellowship at NYU Langone Medical Center. She is board certified in clinical cardiac electrophysiology. She has been director of Cardiac Research at Hackensack University Medical Center since 2005, in addition to the full-time practice of cardiac electrophysiology at Hackensack University Medical Center. She is a fellow of the American College of Cardiology, and a fellow of the Heart Rhythm Society. I love seeing and treating my patients, some of whom Ive known for 20 years, Dr. Glotzer said. I feel privileged to be able to take care of them.

For information about Hackensack Meridian Healths cardiovascular services, visit http://www.hackensackmeridianhealth.org/en/Services/Heart-Care. For information about the Hackensack Meridian School of Medicine, visit http://www.hmsom.org/.

ABOUT HACKENSACK MERIDIAN SCHOOL OF MEDICINE

The Hackensack Meridian School of Medicine, the first private medical school in New Jersey in more than 50 years, welcomed its first class of students in 2018 to its On3 campus in Nutley and Clifton. Hackensack MeridianHealthassumed its independent operation in July 2020. The schools vision is that each person in New Jersey, and in the United States, regardless of race or socioeconomic status, will enjoy the highest levels of wellness in an economically and behaviorally sustainable fashion. The Schools unique curriculum focuses on linking the basic science with clinical relevance, through an integrated curriculum in a team-oriented, collaborative environment. The school prides itself on outreach, through programs like the Human Dimension, which is active in communities across New Jersey.

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Hackensack Meridian School of Medicine Professor and Director of Cardiac Research at Hackensack University Medical Center Named American Heart...

PRAIRIE DU SAC, Wis., June 28, 2022 /PRNewswire/ -- Mueller Sports Medicine, a trusted leader in sports medicine for more than 60 years,has introduced the 'SKY ANKLE STABILIZER'.

The SKY Stabilizer is uniquely engineered to aid in promoting a more stable positioning range, thereby reducing potential for serious injury that could lead to chronic ankle instability.

The SKY Stabilizer, represents remarkably radical out-of-the-box vision and engineering aimed at providing featherlight and streamlined support to athletes with healthy ankles and want to keep them that way.

Ankle sprains are the #1 sport injury and often it only takes a couple of sprains to weaken an ankle joint such that CAI (chronic ankle instability) becomes a significant risk.

Highly specific and refined, the SKY Stabilizer was born from Mueller's focus upon the biomechanics and causal factors of inversion sprains among athletes focused upon jumping vertically, such as basketball and volleyball players. Research revealed an unrecognized opportunity to enhance ankle protection by lessening the tendency for these athletes to let their feet drop while airborne. This in turn helps keep the ankle in a more stable landing posture and less susceptible to dangerous hyper-ranging in scenarios when they land awkwardly, such as on another player's foot.

The SKY Stabilizer is uniquely engineered to aid in promoting a more stable positioning range, thereby reducing potential for serious injury that could lead to chronic ankle instability.The Sky Ankle Stabilizer represents Mueller's disruptive forward thinking,"said John Cayer, President of Mueller Sports Medicine. "It's a radical departure from the traditional approaches to ankle protection.We want athletes to focus on the game without worry of ankle injury."

Mueller's approach is unique because the SKY, 'feels almost invisible', while wearing it. Many athletes tend to forget they have it on.

ABOUT MUELLER SPORTS MEDICINE

Mueller Sports Medicine, Inc. was founded more than 60 years ago by former University of Wisconsin basketball player turned registered pharmacist, Curt Mueller, who coined the term "sports medicine." The company was based on developing better products to protect athletes from injury and enhance their performance and has expanded into the overall health and wellness segment for all audiences.

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Mueller, which continues to be a family-owned company, was the first company to offer knee braces with the patented Triaxial Hinge (U.S. Patent Nos. 4,726,362 and 4,573,455) designed to properly track the knee joint and provide near-normal motion. Other products include HydraCinn fabric, a moisture-management system that is soft, comfortable, durable and breathable for long term use, Mueller Green, an earth-friendly line of braces and supports, and Mueller TYPHOON Kinesiology Tape, featuring a revolutionary wave pattern adhesive that moves with the skin and muscles. Other brands include Sport Care, Thor, Omniforce, PFTape, Hot Stuff, Hg80 featuring HydraCinn fabric , Stickum, MTape, ProStrips, Athletic Care, Recoil and Quench Gum.

The extensive line of sports medicine products can be found in more than 100 countries.www.muellersportsmed.com.

Cision

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MUELLER SPORTS MEDICINE LAUNCHES THE 'SKY STABILIZER', A REVOLUTIONARY APPROACH TO PROTECTING HEALTHY ANKLES - Yahoo Finance

As the Indian rupee has continued to plunge against the dollar amid weakness in domestic shares, this has led to a sharp rise in the cost of medicine in the country. According to a report by Live Hindustan, Livemint's sister publication, the prices of medicines have increased by 30% in Uttarakhand. Most of the new batches of medicines available at medical stores are coming with inflated prices in the hilly state, the daily noted.

Pramod Kalani, Head of the Drug Manufacturing Association, said that the raw material of medicines is becoming increasingly expensive in the international market. Due to the strengthening of the dollar against the rupee, the prices of raw materials are also increasing, he said.

The raw material of Paracetamol, which was earlier 5,000 per kg, has now reached 9,000 per kg. Because of this, companies have had to increase the prices of some medicines.

Manish Nanda, Head of the Wholesale Chemist Association, said that in the last month, the price of medicines has increased by 10 to 30%.

State Drug Controller Tajbar Jaggi admitted that drug makers are increasing the prices of medicines because of the hike in crude oil prices. However, he said that the prices of the scheduled medicines which come under price control cannot be increased.

Increase in drug prices

Medicine old rates new rates

Sugar Injection (Ryzodeg) 1024 1126

Sugar Injection (Lentus) 722 794

Sugar medicine (Glycomet) 155 170

Liver Medicine (Udiliv) 580 694

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From BP to sugar, medicines get expensive by up to 30% in this state | Mint - Mint

New Jersey, United States This Nuclear Medicine Market research examines the state and future prospects of the Nuclear Medicine market from the perspectives of competitors, regions, products, and end Applications/industries. The Worldwide Nuclear Medicine market is segmented by product and Application/end industries in this analysis, which also analyses the different players in the global and key regions.

The analysis for the Nuclear Medicine market is included in this report in its entirety. The in-depth secondary research, primary interviews, and internal expert reviews went into the Nuclear Medicine reports market estimates. These market estimates were taken into account by researching the effects of different social, political, and economic aspects, as well as the present market dynamics, on the growth of the Nuclear Medicine market.

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Key Players Mentioned in the Nuclear Medicine Market Research Report:

General Electric Co., Bayer AG, Lantheus Medical Imaging Medtronic and Cardinal Health Inc.

The Porters Five Forces analysis, which explains the five forces: customers bargaining power, distributors bargaining power, the threat of substitute products, and degree of competition in the Nuclear Medicine Market, is included in the report along with the market overview, which includes the market dynamics. It describes the different players who make up the market ecosystem, including system integrators, middlemen, and end-users. The competitive environment of the Nuclear Medicine marketis another major topic of the report. For enhanced decision-making, the research also provides in-depth details regarding the COVID-19 scenario and its influence on the market.

Nuclear MedicineMarket Segmentation:

Nuclear Medicine Market, By Type

Diagnostic Therapeutic

Nuclear Medicine Market, By Modality

SPECT PET Alpha-emitters Beta-emitters Brachytherapy

Nuclear Medicine Market, By Application

Oncology Cardiology Neurology Thyroid

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Nuclear Medicine Market Report Scope

Key questions answered in the report:

1. Which are the five top players of the Nuclear Medicine market?

2. How will the Nuclear Medicine market change in the next five years?

3. Which product and application will take a lions share of the Nuclear Medicine market?

4. What are the drivers and restraints of the Nuclear Medicine market?

5. Which regional market will show the highest growth?

6. What will be the CAGR and size of the Nuclear Medicine market throughout the forecast period?

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Nuclear Medicine Market Size, Scope and Forecast | General Electric Co., Bayer AG, Lantheus Medical Imaging Medtronic and Cardinal Health Inc. ...

Dear Colleagues,

We are pleased to share with you that Mary E. Klotman, MD, has been reappointed for a second five-year term as dean of the Duke University School of Medicine, vice chancellor for health affairs at Duke University, and chief academic officer for Duke University Health System. Her new term begins on July 1, 2022.

Dr. Klotman has led Duke University School of Medicine through one of the most challenging eras in our more than 90-year history. Thanks to her leadership and to the extraordinary contributions of our faculty and staff, it will also be remembered for its remarkable achievements. Dr. Klotman was first appointed dean of the Duke University School of Medicine in 2017, after serving for nearly seven years with distinction as the chair of Dukes Department of Medicine. Over the past five years, under the leadership of Dean Klotman and in partnership with chairs, center and institute directors, faculty, providers, students, and staff, the School of Medicine has made significant advances in fulfilling the schools priority missions of excellence in patient care, discovery and its translation, education, and community health improvement.

From the outset, Dean Klotman has embraced a One Duke philosophy and commitment to support and service for faculty, staff and students to ensure their success and the continued prominence of the School of Medicine. Currently ranked sixth among all medical schools in the nation for research and third for NIH funding, the school is home to an outstanding community of faculty, staff, students who are recognized nationally as innovators and leaders, and honored for their achievements.

Dean Klotman led the School of Medicine during the COVID-19 pandemic as faculty, staff and students pivoted to focus on urgent needs, making transformative contributions in treatment, testing and surveillance, vaccine development, mitigation and safety guidance, curriculum and training, and community partnerships.

In 2020, under Dr. Klotmans leadership and in partnership with hundreds offaculty, staff, and students, the school began development of its first strategic plan to dismantle racism and advance equity, diversity and inclusion as part of Moments to Movement. Officially launched in 2021, the plan reflects the schools commitment to tangible and sustainable change institutionally and in our broader communities.

In 2021, the School of Medicine, in partnership with Duke University Health System and the PDC, launched a clinical enterprise strategic plan. In spring 2022, a key milestone of that plan was achieved with a formal agreement to create a new integrated clinical practice - to ensure Duke Healths continued leadership in clinical excellence and support of the academic mission.

Dean Klotmans commitment to scientific excellence is reflected in efforts to retain and recruit outstanding research faculty and provide ongoing support to the research community. During her tenure, eight new faculty scholars have been recruited as part of the Duke Science and Technology initiative, and, since 2017, the School of Medicine has constructed new state-of-the-art research facilities including the Chesterfield Building, the Medical Science Research Building (MSRB) III, and Dukes first research campus in Research Triangle Park: Duke Research & Discovery@RTP.

A national leader in science and academic medicine, Dean Klotman is a member of the National Academy of Medicine and a fellow in the American Academy of Arts and Sciences. She is past president of the Association of American Physicians and past president of the Association of Professors of Medicine. A widely-acknowledged authority on HIV, Dean Klotman and her lab are focused specifically on HIV-associated kidney disease. Most recently, she and her team have been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine.

We could not be more pleased to have Dr. Klotman at the helm of the School of Medicine. Please join us in congratulating her on this well-deserved reappointment.

Sincerely,

A. Eugene Washington, MDChancellor for Health Affairs, Duke UniversityPresident and CEO, Duke University Health System

Sally Kornbluth, PhDProvost, Duke University

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Dr. Mary Klotman Reappointed Dean of the School of Medicine - Duke Today

In the future, when ordering a shot of whiskey, the customer might ask the bartender to remove an edible fluorescent silk tag that could be found floating inside, even though it is safe to consume. This little silk tag, with a QR code, is a security measure that could reveal if the whiskey is fake or not.

Simply using a smartphone to scan the tag, which was developed by biomedical engineers from Purdue University and the National Institute of Agricultural Sciences in South Korea, could confirm the drinks authenticity.

Jungwoo Leem, a postdoctoral research associate and Young Kim, both of Purdues Weldon School of Biomedical Engineering, are part of a global research team that has developed an edible QR code on the tag made of specialised silk which could help consumers detect fake whiskey.

There are, of course, no tags currently placed in bottles of whiskey. But this new anti-counterfeiting technology, published in the journal ACS Central Science, could be a step toward not only finding a solution for the alcohol industry but also addressing fake medications.

Some liquid medicines contain alcohol. We wanted to test this first in whiskey because of whiskeys higher alcohol content, said Kim, associate head for research and an associate professor at Purdue. Researchers apply alcohol to silk proteins to make them more durable. Because they tolerate alcohol, the shape of the tag can be maintained for a long time.

Kim has worked on anticounterfeit measures such as cyber-physical watermarks or tags made of fluorescent silk proteins. The tags have a code activated with a smartphone to confirm the authenticity of a product.

The code on the fluorescent silk tag is the equivalent of a 2D barcode or QR code and is not visible to the naked eye. The tags are also edible, causing no issues if a person swallowed it while downing a shot of whiskey. The tags have not affected the taste of the whiskey.

Kim and Leem said making the tags involves processing fluorescent silk cocoons from specialized silkworms to create a biopolymer, which can be formed into a variety of patterns to encode the information. They placed tags in various brands and price points of whiskey over a 10-month period and were able to continually activate the tags and codes with a smartphone app.

Alcohol spirits are vulnerable to counterfeiting. There are a lot of fake whiskeys being sold, said Leem, referencing other studies mentioned in the journal article about the economic cost and loss of purchasing fake alcoholic spirits, including how 18% of adults in the United Kingdom experienced purchasing counterfeit alcoholic spirits.

Online pharmacies sell controlled substances to teens. People can buy counterfeit opioids easily. This work is extremely important for patients and buyers in addressing this issue, Kim said. If you have this technology on or in your medicines, you can use your smartphone to authenticate. We want to empower patients to be aware of this issue. We want to work with pharmaceutical companies and alcohol producers to help them address this issue.

Kim said the tags are an additional authentication mechanism for marked safety seals on bottles or pills and could help by being placed in high-dollar bottles of alcohol or individually on expensive medications.

This article was created in collaboration with AIPIA (the Active and Intelligent Packaging Industry Association). Packaging Europe and AIPIA are joining forces to bring news and commentary about the active and intelligent packaging landscape to a larger audience. To learn more about this partnership, click here.

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Edible silk tag can prove your alcohol or medicine is authentic - Packaging Europe

Egoitz Bengoetxea IguaranGetty Images

Aiming for 50 ground-to-over-shoulders is a daunting task, but this workout ups the ante by throwing in a little extra. Start a running clock and do one press-up and one body-weight squat at the start of every minute, before racking up as many reps as you can with the D-ball. Each new minute, add an additional rep to both moves. Can you make it to 50 lifts before the 60 secs are swallowed up by body-weight moves?

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Hit the deck and assume a strong plank position with hands stacked beneath your shoulders. Lower your chest to the ground before driving back up explosively. Next, jump to your feet, place them shoulder- width apart and drop down into a deep squat. Stand back up with intent and get ready to ball.

With a press-up and squat in the bag, stand over your ball, squat and roll it from side to side, working your hands underneath. Drive through your feet to deadlift the ball before dropping it into your lap and squatting down. From here, wrap your arms around it and stand, using your momentum to roll it up and over your shoulder. Repeat, keeping an eye on the clock.

Work your way through as many D-ball reps as possible until the clock rolls over into a new minute. At this point, drop your ball and make your way to the floor for another round of press-ups. This time, hit two reps before standing tall and hitting two squats. Grab your ball and immediately get back to work, racking up those reps. Try not to lose count

Keep chipping away at those 50 reps. As each new minute rolls around, stop for the scheduled press-ups and squats, adding an additional rep every 60 secs, before recommencing the ball games. As time ticks on, the body-weight work is going to eat further into each minute, not only leaving you less time to get that ball up, but also compounding the fatigue on your upper body and legs. Can you beat the clock?

This content is created and maintained by a third party, and imported onto this page to help users provide their email addresses. You may be able to find more information about this and similar content at piano.io

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Blast Calories In This Medicine Ball Finisher - Men's Health

The sweltering summer heat is upon us. We often think of the basics for our kids, like sunscreen and a water bottle. But when the temperatures rise, knowing how to spot the signs of heat exhaustion and heat stroke is critical to their health and safety.

Heat exhaustion and heat stroke exist on a spectrum of heat-related illnesses, ranging from mild and treatable at home to an extreme emergency. Both share related symptoms, but there are some differences.

"Symptoms in children may be more difficult to identify as they can't always tell us what they are feeling, says Amber Brown Keebler, MD, Nebraska Medicine pediatrician. "Risk of heat exhaustion and heat stroke is increased with prolonged exercise, particularly in hot environments and prolonged exposure to hot and humid temperatures. If the signs and symptoms are identified, it is important to cool down their body temperature immediately."

Causes of heat-related illness:

Symptoms of heat exhaustion are essential to recognize as they can lead to a more dangerous, life-threatening form of heat illness called heat stroke. Seek medical attention if symptoms are severe or do not improve with intervention within 30 minutes.

Heat stroke (or sunstroke) is a life-threatening emergency that occurs when the body creates more heat than it can release. Heat stroke must be treated immediately. The signs of heat stroke may look similar to heat exhaustion but with a few differentiations:

If you suspect your child has heat stroke, call 911 or go to the emergency room immediately.

Heat illnesses are nothing to ignore or push through. Babies, children, and older adults are at the most significant risk. Heat exhaustion and heat stroke are preventable with the proper safety actions:

Read more about children staying hydrated while playing sports, summer injury prevention tips and ways to keep your summer safe.

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Heat exhaustion and heat stroke in children: Symptoms and prevention - Nebraska Medicine

One of USC Dornsife's most distinguished alumni, Joseph Medicine Crow was a renowned Native American historian, the last war chief of the Apsalooke (Crow) Nation and the recipient of a Presidential Medal of Freedom. In April, USC honored him by officially naming a historic campus building after him.

Serving as a U.S. Army scout during World War II, Joseph Medicine Crow was rounding a corner in a small French town when he collided with a strapping, young German soldier. Medicine Crow, who was wearing war paint beneath his uniform and had a yellow eagle feather concealed inside his helmet, was not a big man, but he didnt shoot the enemy. Instead, he disarmed the German with a boot thrust. Throwing his own rifle aside, he overpowered the larger man in hand-to-hand combat. While Medicine Crow was choking him, the Germans eyes rolled back in his head and he gasped Mama, Mama. Recounting the tale many years later, Medicine Crow said the soldiers plea brought him to his senses.

I let go of him and got my rifle back and he became my prisoner, he told his son, Ronald Medicine Crow. We sat down, away from all the shouting and fighting, and I shared a cigarette with him.

This exploit is a perfect illustration of not only Medicine Crows bravery, but also his profound humanity a quality that brought him some of the worlds highest honors, as well as the respect of all who met him.

A Lifetime of Honors

One of USC Dornsifes most distinguished alumni, Joseph Medicine Crow was a renowned Native American historian and writer, the last war chief of the Apsalooke (Crow) Nation and its first member to earn a masters degree. In 2009, President Barack Obama honored him with the nations highest civilian honor, thePresidential Medal of Freedom, in recognition of his military service and contributions to Native American history. The previous year, he was awarded a Bronze Star and theLgion dHonneur Frances highest order of merit for his service in World War II.

According to Crow tradition, a warrior must fulfill four requirements to be named a war chief. Medicine Crow accomplished all four during WWII: leading a successful war party, touching an enemy soldier without killing him, disarming an enemy soldier, and capturing an enemys horse. Indeed, among his war exploits, Medicine Crow is credited with capturing 50 horses from a Nazi SS camp and successfully leading a team of soldiers to dynamite German artillery.

He also claimed to be the first Allied soldier to land in Nazi Germany after his captain ordered him to leap over the narrow stream that marked the Siegfried Line separating the country from France a feat for which he was later congratulated by General Omar Bradley, one of General Dwight Eisenhowers right-hand men.

An All-Round Man

Born into the Whistling Waters clan on the Crow Reservation in Lodge Grass, Montana, in 1913, Medicine Crow came from a distinguished lineage: His paternal grandfather was the eminent Chief Medicine Crow and his step-father was the son of White Man Runs Him one of George Armstrong Custers four personal scouts at the Battle of Little Bighorn.

Medicine Crow was raised by his grandparents, who immersed him in Crow traditions, inculcating stamina and tribal skills.

His Grandfather Yellowtail trained him in the old warrior ways, Ronald Medicine Crow says. In wintertime, they chopped a hole in the ice and took a refreshing morning plunge. Then Yellowtail told him to run a hundred yards in the snow barefoot. In summer and fall, Dad learned hunting and tracking skills.

My father was raised as a farm boy, rancher, outdoorsman, hunter, cowboy, jockey and exercise boy he was an all-round man.

During his formative years, Joseph Medicine Crow was also absorbing the history of his tribe. When elders gathered at the sweat lodge, telling stories of intertribal warfare and mythological heroes, Medicine Crow, who served as their water boy, was listening and taking mental note.

This early knowledge forged a lifelong love of Native American history. Widely recognized as the last person to have heard accounts of theBattle of Little Bighorndirectly from participants in the 1876 conflict and a naturally gifted storyteller in his own right, Medicine Crow grew up to be revered as one of the most influential and knowledgeable carriers of his peoples oral history.

After WWII, he became tribal historian for the Apsalooke (Crow) Tribal Council, documenting his peoples traditions and daily life in several books, includingFrom the Heart of the Crow Country: The Crow Indians Own Stories(Crown, 1992).

Perseverance Pays Off

Unable to speak English as a young child, Medicine Crows formal education got off to a rough start when he struggled to pronounce excuse me to his teachers satisfaction after suffering a bout of hiccups on his first day. She made him don a dunces cap and sent him to the sand box to play with wooden blocks. This treatment continued for his first two years of school.

From eighth grade through his first two years of college, Medicine Crow attended Bacone College in Oklahoma, becoming a star pitcher for the baseball team and excelling at javelin. He became an accomplished musician, learning to play six instruments saxophone, clarinet, flute, piano, accordion and the Indian hand drum.

In high school, he also began to study seriously, competing with a friend to get top grades.

Thats how he came from being in the sandbox with a dunces cap to being an A student and making the honor roll, Ronald Medicine Crow says.

Joseph Medicine Crow pursued his studies at Linfield College in Oregon before arriving at USC Dornsife in 1938 on a scholarship. He earned his masters inanthropologywith anarchaeologyminor in 1939. His thesis, The Effects of European Culture Contacts Upon the Economic, Social and Religious Life of the Crow Indians, is regarded as the seminal scholarly work on the topic.

By the early 1940s, Medicine Crow had completed the coursework to earn a PhD at USC Dornsife, but determined to serve his country, he joined the U.S. Army in 1942. USC awarded him an honorary doctorate of humane letters in 2003 one of four honorary doctorates he received during his lifetime.

Upon returning home from WWII, Medicine Crow started a successful career as a land appraiser for the Bureau of Indian Affairs. There he put his archaeology training at USC to good use, surveying land to ensure no sacred burial sites or artifacts were disturbed by development.

Peace Chief

Saddened by the anti-Native American discrimination he witnessed, he hit upon the idea of creating a Miss Indian America pageant to help promote unity between the white and Indian people. Held during the All-American Indian Days an annual celebration of Native American culture and another initiative of Medicine Crow to foster positive relations the pageant was a success. It changed the climate, and pretty soon we were more than welcome to come into town and do business, says Ronald Medicine Crow.

Joseph Medicine Crow showed a lifelong commitment to education, teaching in the Department of Crow Studies at Montanas Little Big Horn College. A middle school in Billings, Montana, was named after him.

And in 2000, the war chief who was also a devout Baptist who taught a mens Sunday school class performed the opening song for the United Nations summit conference for spiritual and religious leaders.

Ronald Medicine Crow says his father was profoundly influenced by Christianity and did his best to live a good life and be a role model for young and old alike.

My father said, I live in two worlds: the Indian world and the white world. There is a middle line that joins those two worlds together. I walk that line and take whats good from both.

Dad was a humanist who loved all people, even his enemies, He was a man of dignity, but a humble man. He didnt hold grudges. He was forgiving and positive. And people loved him for that.

A Trailblazer and A Role Model

Medicine Crow died on April 2, 2016, at age 102. State officials attended his funeral, and tributes poured in from all over the world, including from Obama.

The tributes continued even after Medicine Crows death.

This year, on April 16, USC honored the USC Dornsife alumnus by officially naming a historic campus building after him. TheDr. Joseph Medicine Crow Center for International and Public Affairsis located at the heart of USCs University Park campus, its tower topped by one of the universitys most visible and recognizable landmarks the stylized globe. The center is home to many USC Dornsife departments, including anthropology,art history,political science and international relations.A scholarship program for Native Americans will also be established in his name.

In her speech at the naming ceremony, USC Dornsife Dean Amber D. Miller paid tribute to Medicine Crow, describing him as a bridgebuilder.

He connected new generations with stories of their past, helped communities overcome intolerance toward indigenous peoples, and found ways to link the Crow peoples cultural traditions with the opportunities of modern society, she said.

Joe Medicine Crow was also known for being a generous mentor he was patient and encouraging and eager to invest in others. Most importantly, he showed how to live through his actions.S.B.

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Profile: The War Chief Who Became a Peace Chief > News > USC Dornsife - USC Dornsife College of Letters, Arts and Sciences

The below clickable headlines link directly to outside media outlets, which featured UNC School of Medicine faculty during the past week, starting Friday June 17, 2022.

16 Healthcare Innovators That You Should Know Dr. Samantha Meltzer-Brody (Forbes)

How to Keep Yourself and Loved Ones Safe as Heat Waves Scorch the Country Dr. David Berkoff (Everyday Health)

A Happy Cancer Story Dr. Hanna Sanoff (AMAC)

Anorexia Nervosa: More Than Just a Psychological Disorder? Dr. Cynthia Bulik (Psychology Today)

Be prepared if your child gets sick on vacation Dr. Anita Skariah, Dr. Priyanka Rao (WRAL)

California thinks it can be an abortion sanctuary in a post-Roe nation. These battlegrounds tell a different story Dr. Amy G. Bryant (Rome News-Tribune)

Triangle families plan to vaccinate young kids this week with new FDA authorization Dr. David Wohl (WTVD)

A new generation of weight loss drugs makes bold promises, but who really wins? Dr. John Buse (Quartz)

Study led by UNC Lineberger finds diagnostic mammography results varied across racial and ethnic groups Dr. Sarah Nyante (CBS 17)

Fighting startup failure: Innovate Carolina rolls out a venture studio approach Carol Lewis (WRAL Tech Wire)

Are you ready to catch COVID again? 1 in 9 cases in June is a reinfection Dr. David Wohl (WNCT)

Do race and ethnicity impact the accuracy of diagnostic mammograms? Dr. Sarah J. Nyante (Health Imaging)

CDC recommends all children under 5 receive COVID-19 vax, shipments expected to arrive in Wake on Monday Dr. Matthew Vogt (WRAL)

Why the world of LGBTQ health doesnt fit under a single label Tonia Poteat (American Heart Association)

Apex 1-year-old finishes a year of chemotherapy Dr. Gerardo Quezada (WRAL Go Ask Mom)

This Cancer Treatment Has a 100 Percent Success Rate, Study Says Dr. Hanna Sanoff (Best Life)

Different brands, doses, schedules and what parents need to know about COVID-19 vaccines for babies, young kids Dr. David Weber (WNCN)

Only a quarter of eligible NC kids receive COVID vaccine, data shows Dr. David Wohl (WTVD)

Diagnostic mammogram accuracy varies across racial, ethnic groups Dr. Sarah J. Nyante (Healio)

Slowly, Then All at Once Dr. Shekinah Elmore (UNC Endeavors)

Vaccines for children under 5: Experts answer parents questions Dr. Tom Belhorn, Dr. Zach Willis (WRAL)

Feelings of detachment predict worse mental health outcomes after trauma Dr. Samuel McLean (Science Daily)

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Newsworthy from the School of Medicine, Week of June 17 - June 23 | Newsroom - UNC Health and UNC School of Medicine

The Canadian Hockey League announced Tuesday the Order of Selections for the 2022 CHL Import Draft, to be held online Friday, July 1 at 9:00 a.m. MT.

The Medicine Hat Tigershold the first-overall selection, to be followed by the Ontario Hockey Leagues Saginaw Spirit and the Quebec Major Junior Hockey Leagues Cape Breton Eagles.

Medicine Hat will select first overall in the CHL Import Draft for the second time in franchise history. The Tigers drafted Czech defenceman Vladimir Sicak with the first pick in the 1998 CHL Import Draft; Sicak went on to skate in 105 WHL regular season games with Medicine Hat from 1998-2000.

The Tigers are the first WHL Club to select first overall in the CHL Import Draft since the Swift Current Broncos selected Finnish defenceman Kasper Puutio in 2019.

Each of the 60 CHL Clubs are permitted to make a maximum of two selections in the 2022 CHL Import Draft.

2022 CHL Import Draft WHL Selections

Round One1. Medicine Hat Tigers4. Tri-City Americans7. Victoria Royals10. Vancouver Giants13. Spokane Chiefs16. Prince George Cougars19. Calgary Hitmen22. Swift Current Broncos25. Regina Pats28. Prince Albert Raiders31. Lethbridge Hurricanes34. Brandon Wheat Kings37. Saskatoon Blades40. Moose Jaw Warriors43. Kelowna Rockets46. Seattle Thunderbirds49. Red Deer Rebels52. Portland Winterhawks55. Kamloops Blazers57. Everett Silvertips59. Edmonton Oil Kings60. Winnipeg ICE

Round One61. Medicine Hat Tigers64. Tri-City Americans67. Victoria Royals70. Vancouver Giants73. Spokane Chiefs76. Prince George Cougars79. Calgary Hitmen82. Swift Current Broncos85. Regina Pats88. Prince Albert Raiders91. Lethbridge Hurricanes94. Brandon Wheat Kings97. Saskatoon Blades100. Moose Jaw Warriors103. Kelowna Rockets106. Seattle Thunderbirds109. Red Deer Rebels112. Portland Winterhawks115. Kamloops Blazers117. Everett Silvertips119. Edmonton Oil Kings120. Winnipeg ICE

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Medicine Hat Tigers to select first overall in 2022 CHL Import Draft WHL Network - Western Hockey League

You may think its a no-brainer that people want to live longer. Butnearly half of Americans said that whether theyd like to live past 100 depends on whether they are in pain or able to do so independentlywhen polled by Axios in 2018.

Thats why longevity, at least how its spoken about in the sphere of wellness, is not just about existing as long as you possibly canits about preserving your quality of life throughout your old age. And longevity medicine is interested in accomplishing both of these tasks.

Longevity medicine is a fast-evolving subspecialty of preventative precision medicinemeaning its focused on customizing health plans for patients in order to stave off common-killers like cancer, diabetes, and heart disease.

What separates longevity medicine from traditional care, is that it is powered by cutting-edge research and recent advancements in artificial intelligence. This combo has allowed longevity experts to learn more about the science of aging over the last decade than was discovered in the entire span of human history that came before.

Another distinguishing characteristic is that longevity medicine considers aging a condition that can and should be treated, whereas in traditional healthcare spaces, aging has always been seen as an inevitability.

Though it has skyrocketed in hype and funding in recent years, longevity medicine is still in its infancy. In fact, physicians and scientists partnered to launch the first-ever longevity medicine course for physicians in March. The course was designed to make the core concepts of longevity available to the practicing medical community, so that, when this kind of care becomes available in a clinical setting, physicians will be able to offer it to their patients right away.

Even though the course is designed to be taught to medical professionals, we took a look at the learning materials and gleaned what the future holds for longevity medicine.

The last 10 years have seen huge advancements in machine learning, a part of artificial intelligence where a computer algorithm can synthesize complex datasets and improve automatically as it is exposed to more information. This has coincided with the rise of longevity medicine and has assisted researchers in learning more about cross-species aging patterns. Artificial intelligence has also prompted the development of deep learning aging clocks, a technology that is able to target and analyze biomarkers of aging.

Speaking of which, longevity experts are rapidly expanding their knowledge of these signifiers. A biomarker is something that is measurable and can indicate the state of your health. When you have your blood pressure taken or your cholesterol levels analyzed at your yearly physical, that is your doctor using biomarkers to learn more about your body.

The science of biomarkers for aging is central to longevity medicine but is still in the research-an- development stage. Grey hair and wrinkles are not the kind of biomarkers theyre looking forthey want to find something on the cellular level that gives an indication of how your body is aging and, more specifically, the rate at which your body is aging. Right now, there are multiple kinds of data that can be used to predict age, like gene expression, your microbiome, and certain kinds of imaging data.

In order to understand geroprotectors, we have to talk about senescence. Senescence is what is happening inside the body when we age: Our cells stop dividing and become dysfunctional, prompting the decline of organ health and the familiar deterioration associated with growing older.

A geroprotector is a compound that can stop or reverse this process of cellular aging. Studies have suggested different nutrients like melatonin, carnosine, and metformin could operate as geroprotectors in animals, but more research is needed before this kind of treatment is available to human patients.

Oh hi! You look like someone who loves free workouts, discounts for cutting-edge wellness brands, and exclusive Well+Good content. Sign up for Well+, our online community of wellness insiders, and unlock your rewards instantly.

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These Are the Core Concepts of Longevity MedicineAKA How Were Going to Live Longer and Better - Well+Good

Yale researchers expand their work on long COVID in conjunction with Survivor Corps to study how vaccinations are affecting long COVID symptoms.

Yash Roy 11:45 pm, Nov 28, 2021

Contributing Reporter

Jessai Flores

Researchers at the Yale School of Medicine are currently engaged in a year-long study to investigate the long-term effects of COVID-19, colloquially termed long COVID.

Symptoms of long COVID include fatigue, shortness of breath, difficulty concentrating, sleep disorders, fevers, anxiety and depression, all of which can persist for months after initially contracting and recovering from COVID-19. In recent months, professors and community members at the School of Medicine have turned their focus towards the condition, according to professor of medicine Harlan Krumholz. A study currently underway aims to track the long-term implications of COVID-19 vaccines on previously infected individuals who continue to suffer from long COVID.

What were trying to do is bring together the best of clinical and epidemiologic science with basic biological science and to then make some kinds of conclusions about what it is that people are experiencing [with long COVID], Krumholz said. What are the factors that seem to be associated with better or worse trajectories? And what are the underlying biological factors that seem to be underlying some of these syndromes [with long COVID]?

Krumholz explained that Yale researchers started their inquiry into long COVID with research conducted in February by Albert Ko, professor of epidemiology at the Yale School of Public Health. Ko started to develop large scale studies of healthcare workers, and collect both blood and information about [them] from the outset. The aim of this study was to determine the long-term effects of COVID-19.

For the study, Yale researchers turned to Akiko Iwasaki, professor of immunobiology and molecular, cellular and developmental biology and of epidemiology at the School of Medicine, and also partnered with Survivor Corps, the largest COVID-19 survivor organization in the United States.

[Our] goal is to try to understand the disease pathogenesis behind long COVID, Iwasaki said. And the tool that were using is to really leverage the changes in the immune responses that occur after vaccination. [Vaccinations] are therapy or intervention where people have reported significant changes in their symptoms. The vaccines themselves arent going to be a cure for the long COVID, but its a means for us to learn about how the vaccine might improve somebodys symptoms. And so we can emulate that better with a more appropriate therapy.

The study has tested five different hypotheses on why long COVID exists, according to Iwasaki. Among them is the viral reservoir hypothesis, in which infectious particles or remnants of the virus persist in the bodies of people afflicted with long COVID. The second is that autoimmune diseases are triggered by COVID-19. The third centers around microbiomes and the balance of good and bad bacteria in the body. The fourth stems from unrepaired tissue damage, and the fifth focuses on the reactivation of previous viruses, like herpes. While there are five distinct hypotheses, Iwasaki explained that the underlying reasons for long COVID might be a combination of these.

According to Diana Berrent, founder of Survivor Corps, she and Iwasaki began to work together to study long COVID in people who had been vaccinated after connecting over social media.

It started off as a Twitter conversation, Berrent explained. The study was eventually launched in the spring and was completed over the summer as a longitudinal study [a study that observes variables over a long period of time]. So, this is an example of citizens and scientists working together to make science go at little warp speed.

According to Iwasaki, the partnership with Survivor Corps helped facilitate enrollment in the study, since at the time of her February conversation with Berrent the organization already had about 100,000 members who had been infected with COVID-19.

The first stage of the vaccination study concluded this summer. Due to recent impositions of vaccine mandates throughout the U.S., the researchers are expanding upon their existing research by increasing the number of individuals in the study and watching their symptoms through the end of next May.

According to Daisy Massey 19, clinical research affiliate at the medical school, the research focuses on the patterns of how vaccinations are changing immune systems and affecting long COVID.

By looking in such detail at the immune system during these immune assays [a procedure that records a response to a given stimulation], the goal is to look for patterns continuously in the people we study and eventually hopefully being able to test hypotheses that we developed together, Massey told the News. The stage were at right now is weve had the first wave of people go through. But with the vaccine mandate, were actually coming up with more people who are planning now to get vaccinated so we are starting to come together and do analyses now.

According to Krumholz, the studies larger implications are the development strategies that have the power to unlock a lot of secrets about whats causing these problems [with long COVID].

Survivor Corps was founded in 2021 to bring COVID-19 survivors together.

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Yale researchers unlock secrets through study of long-term effects of COVID-19 - Yale Daily News

In this episode of The Vet Blast Podcast, Dr Adam Christman is joined by Brendan Lynch, VP of digital strategy and client experience at VCA Animal Hospitals, who discloses not only why innovation matters but also how technology can advance the profession to new heights.

According to Brendan Lynch, VP of digital strategy and client experience at Veterinary Center of America Inc. (VCA) Animal Hospitals, the pandemic brought increased patient demands and higher client expectations with simultaneous veterinary staff shortages, empathy fatigue, and burnout across teams. Ergo, now more than ever innovative change is essential for veterinary professionals to stay healthy and to maintain a prosperous profession.

I believe that its time to evolve, adapt and find new and better ways to do things that help our veterinary teams, our clients, and their pets, he told Adam Christman, DVM, MBA, in this episode of The Vet Blast Podcast.

Lynch then described the efforts VCA has made to adapt practice operations during the pandemic and beyond, including how this has benefited clients and veterinary staff alike.

One of the things that I think was exciting that [VCA] leaned into a lotis our digital abilities to improve access to care, increase convenience, and streamline the operational workflows," Lynch said. "We saw close to 50,000 clients use our telehealth services with 165% increase from before the pandemic and then we had sent and received over 11 million text messages between our hospital teams and clients and this was just in 2020 alone.

Weve been seeing this adoption continue to accelerate going into 2021 which has been a great opportunity to help us streamline the experience for our clients and associatesThis year to date, weve conducted or completed close to 2 million mobile payments transactions," he added.

Listen to the full podcast below for more on the strides VCA has been making in veterinary practice innovation.

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Episode 71: The advancements and innovations in veterinary medicine - DVM 360

Scientists have been trying to trace the actual origins of the virus that causes COVID-19 for a while now. For a time, some thought that it was possibly partially engineered as part of a lab experiment but theres some new information in now that points toward the origins being at a live animal market.

Dr. Keith Jerome, head of UW Virology, told Seattles Morning News that he thinks this is going to be the next chapter in a story thats going to go on for a while.

We want to understand where the virus came from because wed like to be able to prevent it next time, Jerome said. If it came from a market with live animals, thats important to know for controlling it. And of course were interested in, did it come from a lab? Because thats also a really bad thing and we need to know.

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The latest findings on the origins are in a new paper from an evolutionary biologist at the University of Arizona named Michael Worobey. Worobey basically looked through as much data as he could find and tried to piece together what happened around the Wuhan market in China, Jerome said.

The idea was that maybe we were kind of tricked by this market thing because the word got out that it was coming from the market, Jerome explained. We looked there hard and thats where we found all the cases. Basically, [Worobey] looked at cases that were found before word got out. So trolled around different hospitals and essentially found that of about 20 early patients, 10 had something to do with this market, particularly places that had some live animals. Its something called a raccoon dog, and they can carry coronaviruses, so it sort of fit that the market was there.

[Worobey] also found out a little bit more about this so-called first patient that kind of made all this complicated because there was an idea that this 41 year old man had COVID on Dec. 8 and was the first case, Jerome continued. It turns out that on Dec. 8, what he actually had was some tooth problems and his COVID symptoms started on the 16th. So he wasnt the first case.

Thats important to mention and to know, Jerome says, because that man had nothing to do with the market. So now, this puts the first case as a vendor at the market on Dec. 11.

Thats the earliest case we know, Dr. Jerome said. It makes us think that the market is more likely the start of this. In my opinion, its certainly not a cut and dried case. And thats why I say, I think we may get some more chapters as people keep looking at this and try to figure this out we sort of peel back the layers of this onion.

The situation is China is very different than that of the United States, Jerome noted when asked if there are people at the live animal markets looking for the next virus. While there are U.S. scientists, and people in the media, and people who work independently and get to disagree, have their own ideas, and research them to get the truth, Jerome points out that things are a lot more controlled in China.

There are no samples from those animals, for example, those were all destroyed, he said. The area where they were was all disinfected before any sampling was done. So we really dont know for sure it was just done differently.

So while there are these groups of people looking out for the next virus, Jerome says theyre probably not able to do it as well as they could in another setting.

As for how COVID-19 got to humans, the hypothesis is still that the virus got between bats.

We know that bats carry coronaviruses, and we know that bats have coronaviruses that are very, very similar to SARS-CoV-2, but there are some important differences, Dr. Jerome said. So the prevailing idea has been that there must have been some sort of intermediate species that it went from the bat, into something, and then into people. Was it the raccoon dog? You can make a nice story of it. Is there proof? No.

You have lots and lots of these animals in a confined area, Jerome added. Maybe one has been, lets just say as a hypothetical, its been exposed to a bat. Now these raccoon dogs are housed together by a vendor, theyre passing it between each other. The vendor is caring for them, handling them, and so forth. So is the vendor bitten by them, licked by them, just breathing the air? Those are the big questions we really dont know.

I think live markets are inherently dangerous for this sort of thing this is a recurring story, Jerome said. Im not sure that theres a way to make these live markets be safe ideas, frankly. I think its a very difficult thing.

That said, this is not something that would be likely to happen to an individual pet.

It seems very, very unlikely, Jerome said. Is it impossible? No. But I wouldnt worry about about a bat biting my dog. That is that is the last thing virus or not that Im going to worry about for the rest of the day, Jerome said.

Since the vaccine came out, there have been a bunch of new therapeutic drugs for people who either didnt get vaccinated or who have breakthrough infections, or for whatever reason.

I think its a huge deal, Jerome said about the medications. Weve seen the hesitation around the vaccine. I mean, my goodness, the easiest way for this or most health conditions is to prevent them first. Usually thats what people argue for. But weve seen a lot of hesitancy around vaccine, unfortunately.

And once you get COVID, youve heard these stories, people want to get the vaccine and its too late at that point, he added. Then youve got things like the monoclonal antibodies and so forth that are incredibly expensive and you have to get an IV.

These new drugs are exciting, Jerome says, because they work well and theyre pills.

In the early data, they prevent the risk of hospitalization depending on the drug between 50 and 90%. So they keep people out of the hospital, and they keep them from dying, he said.

This, Jerome noted, is a huge advantage for breakthrough cases, people who havent been vaccinated, and especially for people across the world in places where they still dont have access to vaccines.

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As far as when to take the pill, Jerome says sooner is better for almost any antiviral.

Were thinking around the first four or five days after symptoms start, and sooner is better, he said. I think what youre going to see is these get approved and really rolled out widely. If people are in an elevated risk for COVID, theyve got a cough, theyve got some reason to think about that they may have COVID, get that test. And if its positive, you can get on these drugs and hopefully prevent this from becoming a life-threatening illness, which it certainly can today.

To clarify, these will be prescription drugs, not provided over the counter.

Listen to Seattles Morning News weekday mornings from 5 9 a.m. on KIRO Radio, 97.3 FM. Subscribe to thepodcast here.

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UW Medicines head of Virology: Live market more likely the start of COVID - MyNorthwest.com