Encanto and 10 Other Disney Animated Movies That Are Secretly Superhero Films – IGN SOUTH EAST ASIA

Its no secret that superheroes are all the rage in Hollywood right now, especially at Disney, which owns the mighty Marvel roster of characters as well as certain Fox assets like Kingsman, Alita and even Captain Underpants. The Mouse House has also produced their own homegrown cape and tights epics like Pixars two Incredibles films, but have they been producing more stealth entries in the superhero genre all along?

We say yes, and this week Walt Disney Pictures is providing Exhibit A to our assertion with the enchanting fantasy Encanto (read our review). The new animated film follows a Colombian family called the Madrigals who, after a terrible tragedy, were gifted a magical candle that grants powers to each of the newborn children over three generations. That is, it grants powers to all except our lead protagonist Mirabel Madrigal (voiced by Stephanie Beatriz), who stands by and watches her fellow family members flex their super strength (her sister Luisa), healing powers (her mother Julieta), weather control (her aunt Pepa), psychic ability (her uncle Bruno), communication with animals (little cousin Antonio), enhanced hearing (cousin Dolores), or the ability to grow beautiful flowers with a hand gesture (her sister Isabela).

Encanto deftly tracks Mirabels journey of self-discovery as she tries to keep her family together when cracks in the magic begin to occur. While the film has been described since its production announcement in 2016 as having elements of magical realism, comic book fans would not be faulted for finding correlations to superheroes like Storm, Professor X, Animal Man, Daredevil or even Poison Ivy. We even got to ask the movies co-writer/co-director Charise Castro Smith about the parallels between Encanto and other superhero properties.

It's funny, people have been making that comparison, Smith told IGN exclusively. From the inside it doesn't feel that way. From the inside it feels very much like a story about a family a lot like mine. A family with a lot of internal pressures and a lot of love. People who can do extraordinary things, people who have secrets. So yes, the characters in this movie do have superpowers, which is a really cool, interesting element, but I think what I gravitate towards the most is just the relatable family dynamics and sibling relationships. My own relationship with my grandparents, both of them, was a big element that I tried to bring into this story. So sure, yeah, Luisa is totally a superhero!

Luisas super ability to literally carry around a church or village bridge may seem like feats for Superman, but she and the other Madrigals are not alone in the annals of Disney history for seeming to possess superhero traits. Here are 10 other films from the studio that would totally fit the bill of being superhero movies

The tagline of 1978s Superman was Youll believe a man can fly. But what about an elephant? Granted, if you apply the definition of a superhero as any being with extraordinary abilities then just about every animal who ever walked on four legs and spoke in a Disney movie would fall under that category. Yet the character of orphaned Dumbo is exceptional even within the world of the film, as his ability to use his gigantic ears to fly distinguishes him from other circus elephants. He doesnt use this ability to fight crime but to get a Hollywood contract, which is well-deserved and probably what a modern flying elephant would do too.

Another character with the ability to fly is the famed boy who never grew up, Peter Pan. J. M. Barries character from the 1904 play Peter and Wendy checks all the boxes for superhero-dom: Sustained flight? Check. Colorful tights? Check. Immortality? Check. Kid sidekick? Heck, hes got his own gang of Lost Boys. Fights bad guys with strange disfigurements? Yes, Captain Hook definitely qualifies. Cool vehicle? Dudes got his own flying ship! If you need a comic-book corollary, you can look no further than Sprite from Marvel Studios recent Eternals, who in the comics is intended to have actually been Barries inspiration for Peter Pan after Sprite showed off to him one night in 1901.

Like Peter Pan, the title magical nanny played so memorably by Julie Andrews also has the ability to fly, but additionally boasts the power to speak with animals, telekinesis and reality manipulation. Shes also pretty good at transporting herself and others into imaginary worlds rendered in glorious 2D animation. One might say she is "practically perfect in every way." She even got that most superheroic of things, a sequel, with 2018s Mary Poppins Returns where Emily Blunt portrayed her.

Another Disney movie directed by Robert Stevenson (who also helmed Mary Poppins) and featuring a combination of live-action and animation was Bedknobs and Broomsticks, which was sort of a proto-Harry Potter. It stars Angela Lansbury as the good witch Miss Eglantine Price, who uses her magical abilities to fight Nazis during World War II. Shes a bit like John Constantine if he was a dowdy woman who adopted some war orphans. Its also possible she became a mystery writer in coastal Maine later in life, but that remains unconfirmed. The one aspect that separates her from Mary Poppins is she is a witch-in-training, so many of her spells backfire, but she is nevertheless formidable.

Based on the traditional fairy tale that was so memorably adapted by Jean Cocteau in 1946 as La belle et la bte, this 90s classic had the distinction of being the first full-length animated feature to be nominated for a Best Picture Oscar. It follows the beautiful bookworm Belle who frees her father by taking his place as the title Beasts prisoner, then comes down with a serious case of Stockholm syndrome for the hairy monster who was once a prince before he was transformed by an enchantress. This curse turned him into the Beast, but also gifted him with enhanced strength, speed, agility, durability, healing and senses, not to mention some sweet claws and fangs. Stan Lee and Jack Kirby were not feeling super creative when it came time to christen Marvels own blue-tinged version of the character: Hank McCoy, whose nickname on the X-Men team is Beast!

Both Marvel and DC have their own version of the Greek mythological hero, and Hercules papa Zeus was even featured briefly in Zack Snyders Justice League (both the 2017 and 2021 versions). Of course, the Disney version of the super strong hero was more a full-of-himself lunkhead than his comic book counterpart, who in recent years has been outed as gay in the Marvel 616 timeline and is dating a certified Guardian of the Galaxy named Marvel Boy. Still, a guy who principally rescues damsels in distress and fights monsters sounds like a superhero in our book.

This one is cheating slightly, as Edgar Rice Burroughs creation has its roots in the same early 20th century pulp novels that later inspired comic-book superheroes like Batman, The Shadow, etc. The very idea of a feral child raised by apes and being an expert hunter with great dexterity instantly brings to mind Wolverine. In many ways the Wolverine of the films led a kind of wild existence before he was civilized by Professor X, much the same way Jane Porter civilizes Tarzan.

Its fitting that Elsa, loosely based on the titular character from Hans Christian Andersons fable The Snow Queen, was originally envisioned by the filmmakers as the straight-up villain of the film since she has so many similarities to DC Comics baddie Mr. Freeze. Yet she also closely resembles Marvels mutant hero Bobby Drake/Iceman in her ability to conjure and manipulate ice and snow into weapons, shields, escape routes, etc. The fact that her uncontrolled abilities are turning her kingdom of Arendelle into a veritable snowpocalypse goes hand-in-hand with typical X-Men-style drama, i.e. a mutants emotions cause their powers to get so out of hand that they wind up harming or almost harming a ton of peeps. Luckily, Elsa learns to Let It Go proper, and by the sequel Frozen II has mostly mastered her abilities.

Like Mirabel from Encanto, the title Polynesian princess of Moana may not have much in the way of powers, but her sidekick on her journey -- the shape-shifting demigod of the wind and sea and master of sailing named Maui -- certainly qualifies. The fact that he is played with gusto by living superhero Dwayne Johnson only adds to that heroic charisma. Maui is also a bit of a selfish douche, but eventually answers the call of heroism in order to restore the heart of the giant goddess Te Fiti, and fights a ton of big sea monsters along the way. The big guy also has immortality and sentient tattoos, which at a certain point is almost gilding the lily but who are we to complain? Although hes not a comic book-accurate representation, Mauis fellow Pacific Islander Jason Momoa certainly bears some resemblance as Aquaman with his numerous tattoos and overall heroic reluctance.

The Southeast Asian hero Raya is a girl right after Frank Millers heart. Shes badass, excels at martial arts and hand-to-hand combat as well as weapons like swords and sticks, and rides a big bug/armadillo creature named Tuk Tuk just like Millers beautiful assassin Elektra! Okay, maybe Elektra never rode a giant bug-thing, but the similarities are definitely there. Raya is part of the street-level superhero tradition where the persons natural talents and skills more than make up for their lack of standard powers. There is a magical gem at the center of the story with some degree of true power, but its really mostly a MacGuffin to take Raya on her heros journey.

What other Disney characters are secretly superheroes? Lets discuss in the comments!

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Encanto and 10 Other Disney Animated Movies That Are Secretly Superhero Films - IGN SOUTH EAST ASIA

Solar Eclipse 2021: Everything that you need to know – Hindustan Times

The last solar eclipse of the year will take place on 4th December, Saturday. This day will be the new moon day of Krishna Paksha of Margashirsha month. Here are all the details relating to the eclipse.

When it will take place?

The Solar Eclipse will start on December 4 at 10:59 am, and will continue till 03:07 in the afternoon.

Will it be visible in India?

The Solar Eclipse will be visible in Antarctica, South Africa, Southern regions of Atlantic, Australia, and South America, but not in India.

What is the importance of this Solar Eclipse?

The second Solar Eclipse will occur on the Amavasya in the Hindu month of Kartik during the Vikram Samvat 2078 and will mostly impact the natives of Scorpio zodiac sign and those born in Anuradha and Jyeshta Nakshatra.

This will be the last eclipse of this year. This Solar Eclipse comes two weeks after the partial lunar eclipse of November 19. It will be a total eclipse. When the Moon completely covers the surface of the Sun while forming a straight alignment with the Earth and the Sun, it is known as a Total Solar Eclipse.

What is Sutak Kaal?

Sutak Kaal is considered to be a certain time period observed before the Solar Eclipse, which is considered to be inauspicious. According to the Sanatan Dharma, it is the period when the Earth remains under severe contamination due to the malefic influence of Solar Eclipse. In order to get rid of such effects, several religious precautions are necessary to be followed.

The Sutak Kaal during the Solar Eclipse in 2021 depends entirely on the time of eclipse. As per the Panchanga, the Sutak Kaal begins four phases before the time of occurrence of a Solar Eclipse. According to the Hindu Panchaga, there are eight phases or pahars from sunrise to sunset in total, out of which four pahars or twelve hours prior, the Sutak Kaal begins and ends with the end of the Eclipse.

Do we need to observe Sutak Kaal in India?

This eclipse will not be visible in India. Hence, the Sutak Kaal and its impact will not be religiously observed as well. However, Indians staying in South Africa, Southern regions of Atlantic, Australia, and South America should adhere to the Sutak Kaal.

Any remedies we need to perform on the day of the eclipse?

One should avoid undertaking any important activity during the duration of the eclipse. In addition, it is advised to offer water to Sun and chant Aditya Hridya Stotra. One can also donate copper, jaggery, wheat or ghee to a temple.

Do pregnant women need to take any precautions?

Yes, pregnant women are advised to take precautions as the eclipse is believed to impact new life. During this time, the pregnant women should avoid going out of their houses and witnessing the eclipse in any way. During the period of Sutak Kaal on the day of eclipse, women they should refrain from performing tasks like sewing, embroidery, cutting, peeling and cleaning. They should also avoid using knives and needles during the period of the solar eclipse.

What is the mythological significance of Solar Eclipse?

In vedic astrology, the Solar Eclipse is connected to the legend of Rahu and Ketu. According to Matsya Purana, when the amrit or nectar of immortality was extracted from the ocean during the Samudra Manthan, a war began between the Gods and Demons or Asuras since both of them wanted to consume it. In the midst of all, a demon named Swarbhanu planned to consume the nectar by hiding among the Gods. But during all of this, Lord Surya and Lord Chandra revealed his reality by catching him.

As soon as this trick played by the Asura Swarbhanu became known to Lord Vishnu, he became angry and separated his head and torso with his Sudarshan Chakra. But since Swarbhanu had tasted the Amrit, he did not die. Instead, his head was named Rahu, whereas his torso became Rahu. Hence, as a result of his vengeance, every year Rahu covers the Moon and the Sun and causes the phenomenon of Solar Eclipse.

--------------------------------------------

Neeraj Dhankher

(Corporate Astrologer, Founder - Astro Zindagi)

Email:info@astrozindagi.in, neeraj@astrozindagi.in

Url:www.astrozindagi.in

Contact: Noida: +919910094779

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Solar Eclipse 2021: Everything that you need to know - Hindustan Times

Frozen for the future: Does Minnesota have any cryonics …

A number of Minnesotans have made plans to be frozen, and a passionate group of cryonics enthusiasts is trying to ease the transition.

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Minnesotans are used to life in subzero temperatures, but what about death?

Reader Sharon Carlson wanted to know if Minnesota is home to any cryonics facilities, where bodies are kept frozen until theoretical future technology is able to reanimate them. She posed the question to Curious Minnesota, the Star Tribune's reader-powered reporting project.

"I'm just kind of having a hard time with the idea of dying," said the 62-year-old Andover resident. "I'm not philosophical I'm kind of pissed off about it."

There are actually only two cryonics facilities in the nation, in Arizona and Michigan. But a number of Minnesotans have made plans to be frozen, and a passionate group of cryonics enthusiasts is trying to ease the transition from life to long-term storage.

Minnesota Cryonics Rapid Response counts about two dozen members. Most if not all have signed up to spend their postmortem days in large freezers at either the Cryonics Institute (CI) in Clinton Township, Mich., or the Alcor Life Extension Foundation in Scottsdale, Ariz.

When a member dies, time is of the essence.

Other Rapid Response members must stabilize the body as quickly as possible, usually by packing it in ice. The body must be kept cold until it can be shipped to CI or Alcor, where it will be "vitrified" at about 320 degrees below zero Fahrenheit in a vacuum-sealed tube of liquid nitrogen. The response team may administer anti-coagulants to keep the blood from thickening after death.

"Our biggest expense last year was about $150 for ice," said Chris Petersen of Minneapolis, a board member of the rapid response group. "Knowing where your closest 24-hour gas station with an ice freezer has turned out to be a big role."

'Freeze Hank'

Last year, the group launched a GoFundMe fundraiser to help get one of their members, Hank, to the Michigan facility after his death. The "Freeze Hank" campaign didn't raise much only about $2,300. But when Hank died earlier this year, members successfully preserved his body and got it to Michigan.

The primary goal of the fundraiser was to raise money for long-term needs such as an emergency vehicle and monitors that could alert the group when a member's vital functions are failing. They also hope to develop educational materials for paramedics, funeral homes and hospitals, to teach them how to process the body of someone who wants cryonic preservation.

Freezing and reanimation is a frequent theme of Hollywood, playing a prominent role in movies like "Captain America," "Demolition Man" and "Austin Powers."In fact, many of the members of the Rapid Response group were first drawn to cryonics through sci-fi.

"I've always liked the harder part of sci-fi, where the science is plausible," Petersen said. He admits that when he first heard about cryonics, "I thought it sounded kind of quacky."

But Petersen and others maintain that what seems out of the realm of possibility today may be routine in the future. Nobody thought humans could fly; then the Wright brothers did it. A century ago, nobody would have believed a heart transplant was possible, yet today they're not even newsworthy.

Advances in cellular and molecular science are opening doors to medical advances that would have been unheard of even a decade ago, said Dennis Kowalski, president of CI. Scientists routinely freeze and thaw human eggs, sperm, embryos and tissue samples with no ill effects. Who's to say a whole body couldn't be frozen and thawed successfully?

"I don't believe we're at the zenith of human technological knowledge," Kowalski said. "We're going to be smarter in the future than we are today."

Health care of the future

CI has about 200 bodies in vitrification right now, Kowalski said, along with about 200 pets. Walt Disney is not among them, despite rumors that the famed animator had his head frozen after death a rumor Kowalski said is false.

But there is at least one famous person at his facility, Kowalski said, although he can't reveal who it is.

CI, which is a nonprofit organization, requires a donation of $28,000 to be stored at the facility indefinitely, Kowalski said. Many members donate more, with the money often coming from life insurance policies. The institute invests the donations in mutual funds, which are expected to provide money to keep the facility operating into the future.

Of course, if you're frozen after dying of cancer, you will still have a cancer-ridden body when you wake up.

"The issue is when you wake up, they have to fix what killed you," said Gene Shaver of St. Louis Park, another rapid response team member. But that's where members believe science will find a way.

"Let's be very honest here," Petersen said. "This is a long shot that we're doing. But if humanity and civilization is still around 500 or 1,000 years from now, if they have the technology to bring someone back to life, they probably have the technology to do nanotechnology or gene therapy" to treat the cause of death.

And for cryonics advocates, that long shot is better than nothing at all.

As Kowalski put it: "I can be sure that if you don't try, you're going to be worm dirt."

If you'd like to submit a Curious Minnesota question, fill out the form below:

Read more Curious Minnesota stories:

How many people live their entire life in Minnesota?

How did early settlers survive their first Minnesota winters?

What's the truth behind Minnesota's Kensington Runestone?

Who is the oldest living Minnesotan and what is their story?

Are Minnesota's health care costs really the highest in the nation?

Where does Twin Cities electricity come from and how is it delivered to homes?

Correction: Previous versions of this article misspelled Chris Petersens name.

John Reinan is a news reporter covering Greater Minnesota and the Upper Midwest. For the Star Tribune, he's also covered the western Twin Cities suburbs, as well as marketing, advertising and consumer news. He's been a reporter for more than 20 years and also did a stint at a marketing agency.

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Frozen for the future: Does Minnesota have any cryonics ...

Five-Step Guide to Becoming a Sponsored Poker Player – PokerTube

08:3424 Nov

One of the most popular games in the world, poker, is a phenomenon in many countries, with the United States leading the way. Not only do people love playing Texas Holdem in their spare time, but they also enjoy watching poker matches when the top professionals compete.

That is why the top players can not only earn outstanding prize money for winning tournaments, but have the chance to grab lucrative sponsorships from companies that want players to help promote their brands.

If you try your hand at poker and discover that you have a real talent for this game, then you may want to work on making a career out of the game. Below is a five-step guide that explains how you can become a sponsored poker player.

Becoming a poker player when you are new to the game is a big hurdle, but one that you can get over. Start by learning the basics of poker, master the various hands, understand gamesmanship and winning techniques, and then test your hand at gameplay.

When you are at a level where you are confident about beating good players, set up a place where you can put out poker content on the internet. There are countless ways to post videos, including YouTube and various gaming streaming websites. Live-streaming is usually a better bet when you want to gain a following, as people can interact with you in real-time.

A lot of the most popular poker players in the world who have significant sponsorships got them as a result of their exploits on sites like Twitch, YouTube, and recently Facebook Gaming. By establishing such a platform, you become a lot more attractive to any company that may want to offer you a sponsorship.

Establishing a large following is a very good start if you aspire to have a career as a professional poker player. One way to take your brand over the edge is to gain a following in one or two specific demographics, as that will help you gain sponsorships.

Companies have a very good understanding of who does and does not buy their products. While an aspiring poker player may be lucky enough to gain sponsorship from a mega-corporation that has products appealing to nearly all demographics, most such sponsorships come from small and mid-sized companies.

If a poker player can show that they get a lot of views on Twitch and Facebook, but also that most of these views are from men aged 18-30, they are in a very good position. That demographic would be very appealing to companies that have products to market to men in that age group.

Poker players are not unique from other entertainers and gamers in online spaces. They must often tread a very fine line between showboating and demonstrating arrogance, and remaining humble and relatable.

The everyman approach can work wonders when you are attempting to gain a following on Twitch. Even as you win poker tournaments and showcase your skills, remaining humble helps you attract an audience. Eventually, you may want to shift gears ever so slightly.

Showboating and talking up your wins can be helpful when you want to gain sponsorships. Companies want to partner with entertainers and gamers who are willing to put themselves out there. If you talk yourself up, your fanbase will do the same, and that further raises your profile.

Ensure that you tread the fine line between the occasional boast and display of justified arrogance, and the off-putting cockiness that may turn brands away from you.

The moment you open yourself up to scrutiny over the internet, you must forget about the notion of privacy. Whether you are streaming on Twitch, recording a video to post on YouTube, posting a photo on Instagram, or tweeting about a news article on Twitter, you are now a public figure.

Conduct yourself with that in mind during any interaction, especially online. Even if you are in a private chat with another person, you must be careful about what you say. Any statement that is deemed offensive or inappropriate could cause problems for your personal brand, which is problematic for getting sponsorships.

Even if you are lucky enough to secure backing from one or multiple companies, do not let your guard down. Speak your mind and show your personality, but remember that people are always waiting for high profile gamers and entertainers to slip up. Do not give anyone the opportunity to cause problems that could threaten your livelihood.

Someone who has ambitions of becoming a professionally sponsored poker player must prove themselves in tournaments. Even with a decent following on Twitch and other platforms, most companies want to support winners in the long term. That is why poker players, who go many years without a tournament win, can fall off the radar.

Having an appealing personality and marketing yourself will get you very far in this profession. Winning is what takes you over the top, and establishes you as a pro poker player who can match up against the very best. Those are the players any company would want to represent.

Do not despair if you are not already at this level. Many poker players spend years improving their game before they can win big money tournaments. Continue to persevere with your game, play against opponents of different styles, and understand your weaknesses as well. Then you can elevate your game and gain the attention of companies for sponsorships.

Having a career playing poker is not easy, and you must have real talent to succeed in this profession. Not only do you have to spend countless hours perfecting your game, but you do need moments of luck to come away with big winnings at tournaments.

One of the ways to earn and save more money as a poker player is by securing a sponsorship. Having a company that pays you money each month or year helps you become less reliant on winning tournaments to stay afloat.

Even though you must continue to compete and excel to retain and gain sponsorships, you can make more money through this method compared to tournament prize money.

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Five-Step Guide to Becoming a Sponsored Poker Player - PokerTube

The Biggest Bubble in Poker History Bursts in Episode #8 of Triton Million – PokerNews.com

November 28, 2021PokerNews Staff

In 2019, 27 amateurs and 27 of the worlds best pros competed in the biggest buy-in event in history. Now, the Triton Million - A Helping Hand for Charity poker tournament is being released as a 10-episode series on Triton Poker's YouTube Channel.

A total of 54 players stumped up the seven-figure entry fee with 50,000 of each buy-in going to benefit 15 different charities. As a result, this saw 2.7 million going to a plethora of good causes as well as generating a staggering 54 million ($73,993,800) pound prize pool.

Here's a look at five of either the biggest or most interesting hands from the eighth episode, which can be viewed in full below.

With blinds at 50,000/100,000/100,000, Nick Petrangelo opened to 200,000 from a stack of 2,500,000, with the in early position, and received two callers in the shape of Vivek Rajkumar holding the chip lead and the in the cutoff, and Chin Wei Lim with the , and 2,400,000 in the big blind.

The deck kept it low with a flop of , but it handed Rajkumar a flush draw. Wei Lim checked, Petrangelo bet 250,000, and Rajkumar raised to 650,000. Wei Lim folded and Petrangelo moved all in for his tournament life, which Rajkumar called.

Petrangelo needed to avoid a diamond or an ace but failed when the hit the turn at the first hurdle. The completed the action, and Petrangelo departed a few places shy of the money.

With blinds still at 50,000/100,000/100,000, Igor Kurganov found the in the hijack and moved all in for 1,300,000. Bill Perkins called for 1,200,000 with the in the cutoff, and after everyone folded,it was down to the first bubble hand of the event.

The entire room crowded around the table as the dealer fanned the on the flop to give Perkins a middle set. Kurganovs odds rose from 7% to 25% picking up flush and straight outs on a turn, but the on the river enabled Perkins to float on a pink cloud to the final table and leave Kurganov with chip dust.

A few hands later, and Kurganov earned the unwanted tag of losing the biggest bubble hand in poker history after his lost out to the of Rajkumar.

With blinds at 60,000/120,000/120,000, Winfred Yu moved all in for 600,000 in the cutoff holding the and received a call from the big stack, Rajkumar, who had the in the big blind.

Yu maintained his lead on the flop, but Rajkumar overtook him with the top pair after the hit the turn.

Yu left the tournament in 11th place for 1,100,000 after the completed the action on the river.

With blinds at 60,000/120,000/120,000, Chin Wei Lim moved all in for 1,650,000 from the hijack with the , and Bryn Kenney called with the in the big blind.

Kenney needed to flop something to oust the dangerous Lim from the contest, and the gave him everything with a Broadway straight. Lim needed the board to pair on the turn to give him any chance of survival, which happened when the appeared.

Lim needed either a five or a ten to pip Kenney and stave off elimination, but instead, the hit the river to send Lim out in 10th place, receiving 1,100,000 in winnings.

With blinds at 60,000/120,000/120,000, Chan Wai Leong moved all in for 2,600,000 in the small blind holding the , and after some deliberation, Timothy Adams made the call with the covering stack in the big blind holding the dominating . The board ran out , Adams won the hand, and the Triton Million had its final eight players.

Coverage of the 50,000 Triton Million Charity event continues at - million.triton-series.com.

*Images courtesy of Triton Poker/Joe Giron

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The Biggest Bubble in Poker History Bursts in Episode #8 of Triton Million - PokerNews.com

Why are poker players obsessed with CryptoPunk NFTs? – Coin Rivet

Non-fungible tokens (NFTs) appear to be returning from a recent lull with jaw-dropping valuations and volume spikes on platforms like OpenSea as several top poker players lead the charge.

The likes of CryptoPunks and Bored Ape Yacht Club now have price floors of 100ETH ($440,000) and 45ETH ($198,000) respectively, while new play to earn NFTs like Wolf Game boast a market cap of more than $380 million.

NFTs are arguably the most divisive investment assets, some believe that they are a gimmick and a bubble that will die out, whilst others claim they are the future of art and gaming.

One industry that has endorsed NFTs with open arms is poker. High stakes players like Mike McDonald, Jeff Gross, Dan Smith and Ryan Daut all have Crypto Punks worth around $400,000 as their Twitter profile pictures, with Bill Perkins sporting a World of Women NFT.

Poker and NFTs are the perfect fusion. Naturally, poker players like to take risks, even the best player in the world is at risk of losing serious capital if they get stung by an opponents one-out river card, but the key to profitability is being plus EV (Expected Value) over time.

Investments in things like NFTs are a store of value to poker players. Given that its a very novel industry, NFT collectibles like CryptoPunks are expected to soar even more in value to a point where only the worlds elite can afford to buy one.

This, ultimately, is the crux of it all. NFTs have become a status symbol Jay Z, Wolf of Wall Street (Jordan Belfort) and Jason Derulo all have CryptoPunks as their Twitter profile pictures in what is often described as the ultimate flex.

As the world thrusts itself further into the daunting reality of a digital dystopia, there really is no better way of flaunting wealth and status than through an 8-bit retro avatar that is valued at half a million dollars.

It also boils down to simple supply and demand theory. Currently, out of 10,000 CryptoPunks zero of them are listed for sale on OpenSea.

If a young poker player wins a few million from a tournament, in the past they might have bought themselves a new Audemars Piguet watch for $100,000. Now, the goalposts have shifted $500,000 CryptoPunks are the desirable asset as ridiculous as that may seem.

For more iGaming news, click here.

Disclaimer: The views and opinions expressed by the author should not be considered as financial advice. We do not give advice on financial products.

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Why are poker players obsessed with CryptoPunk NFTs? - Coin Rivet

By the Numbers: 17 Years of the World Series of Poker (WSOP) at the Rio – PokerNews.com

November 25, 2021Jon Sofen

The poker world has reached the end of an era with the World Series of Poker (WSOP) concluding its final bracelet event at the Rio All-Suite Hotel & Casino.

Next summer, the series will move down the road to the Las Vegas Strip, the first time the WSOP will take place anywhere but the Rio since 2004, when it was hosted at Binion's downtown.

On June 3, 2005, Anthony Nguyen shipped the $500 Casino Employees No-Limit Hold'em tournament, the first bracelet ever won at the Rio, owned at the time by Harrah's Entertainment, which later became Caesars Entertainment. Allen Cunningham was the first player to win an open bracelet event at the near-Strip property, having taken down a $1,500 NLH tournament two days after Nguyen's win.

The final bracelet won at the Rio, out of the 1,030 total awarded, occurred on Tuesday, with Boris Kolev winning Event #88: $5,000 8-Handed No-Limit Hold'em, exactly 6,019 days since the off-Strip casino first opened its doors to the World Series of Poker.

In between the first champion and the last winner there have been more memorable moments than we can count. But we did dig up some interesting stats on the WSOP during the Rio era, starting with the G.O.A.T. of the WSOP, Phil Hellmuth, who is unsurprisingly the only player to win more than five bracelets at the Caesars-owned resort.

Hellmuth, who won his 16th bracelet last month in Event #31: $1,500 No-Limit 2-7 Lowball Draw, collected six shiny gold bracelets at the Rio. Four others won five, and they are listed as follows:

Doyle Brunson and Johnny Chan's greatest accomplishments were behind them by the time the WSOP left Binion's following the 2004 series. But they each made history at the mega resort.

During the first month the series took place at the Rio in 2005, Chan became the first player ever to reach 10 bracelets when he shipped a $2,500 pot-limit hold'em tournament. Four days later, Brunson reached the double-digit bracelet plateau by taking down a $5,000 no-limit hold'em event. Neither player has since won a WSOP title, although they both still compete in the occasional bracelet event.

Hellmuth would catch up the following summer in a $1,000 no-limit hold'em tournament, and then win his 11th in 2007, a record no one else has since achieved. Phil Ivey is the only other player to win 10 bracelets, but only four occurred at the Rio. The Poker Hall of Famer won his 10th in 2014 when he took down a $1,500 8-game mix tournament.

There are two ways to analyze Daniel Negreanu's performance in bracelet events at the Rio. The first is for those who look at championships as the measuring stick for player success. And the other looks at the overall body of work (titles, final table appearances, cashes, awards, etc.).

Since 2008, Negreanu hasn't won a single bracelet at the Rio, although he won two overseas in 2013. But he's reached 26 final tables two in the past few days at the Las Vegas casino over that span, which is impressive in itself. The GGPoker ambassador won his lone bracelet at the Rio in 2008, and has since gone 0-7 when heads-up for a bracelet.

Daniel Negreanu's Most Mind-Boggling WSOP Stat at the Rio

Roland Israelashvili has produced one of the most intriguing poker careers ever. With 304 cashes in WSOP and WSOP Circuit events, he holds the all-time record, but he's never won a bracelet, although he does have eight circuit rings.

At the Rio, Israelashvili racked up 131 cashes, more than anyone in history. But he did so without winning a bracelet, never reaching heads-up for a bracelet, and only reaching three final tables. He's the consummate min-casher, perhaps even more so than Allen Kessler.

Winning poker's most prestigious annual event doesn't necessarily mean you're a great player. Since 2005, the WSOP has crowned 17 different world champions, and only four of those winners have multiple bracelets Joe Cada (4), Joe McKeehen (3), Jonathan Duhamel (3), and Greg Merson (2).

In total, the WSOP champs in the Rio era have won just eight bracelets outside of the Main Event. Going back even further, none of the champs from 2002-2004 Robert Varkonyi, Chris Moneymaker, or Greg Raymer have won a second bracelet. Times sure have changed since the 1990s and earlier when Main Event champs were often multiple-time bracelet winners.

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By the Numbers: 17 Years of the World Series of Poker (WSOP) at the Rio - PokerNews.com

AEX celebrates its 8th anniversary with ‘Texas Hold’em Poker’ competition – AMBCrypto News

AEX celebrated its 8th anniversary with the 2nd edition of the Texas Holdem Poker Tournament for its users. The tournament was live between 16 November-22 November and have users a chance to win 1 BTC without having to put in any deposit.

The AEX team created the platform in order to provide cryptocurrency enthusiasts a discussion space wherein they can know more about crypto and the market while also getting a chance to trade.

Texas Holdem Poker

Every player gets 3000 points at the start of the game for free and the game sets in a resurrection mechanism. Whenever a player has less than 100 points, they enter the resurrection state and have to complete tasks to get back in the game.

The competition had 2 stages the first called the Texas Championship live from 16 November to 22 November. The second stage of the competition is called the Claim Time and will be live from 23 November to 29 November 2021.

In addition to this, there are jackpot rewards which are divided into The Today Jackpot and the Total Prize Pool. A 20% share of the betting fee and 50 points are charged as a handling fee for each game. 60% of the handling fee gets destroyed every day while a 25% share goes to the Total Jackpot and the remaining 15% to the Today Jackpot.

About AEX

AEX was founded in 2013 and is operated by Bit World Investments Limited. The platform is one of the oldest digital asset exchanges and has evolved from being an original transaction matchmaker to a global digital asset management service provider over time.

The platform has been an advocate of safe investment and sound appreciation in the past 8 years. AEX has fiat currency trading, spot trading, contract trading, lending, DeFi mining, staking, and finance.

AEX has been able to maintain and provide its users with competitive trading, DeFi mining, and much more through bull-bear shifts, policy changes, and much more. It was the first exchange to introduce DOGE, XRP, BTS, XEM, XLM and ARDR in 2013. This helped users unlock the price potential that other cryptocurrencies carried while a lot of exchanges at the time only recognized BTC.

With the 8th anniversary, AEX intends to provide users with the chance to gain access to mainstream cryptocurrency for free.

Advantages and core values

Some of the core values of the AEX platform are:

Conclusion

AEX has a record of 8+ years of safe operation with a cumulative userbase of more than 1 million. The exchange has 300+ trading pairs listed with a 92.3 billion cumulative savings amount.

AEX is one of the leading digital asset exchanges that has been a part of the crypto space for a long time evolving with the space. The Texas Holdem Poker competition gives users a chance to be a part of the 8th-anniversarycelebration of the platform.

AEX Second Global Texas Holdem Competition ended successfully, giving away a total of about $800,000 worth of airdrop benefits, including 1BTC, 55,000 USDT, and millions of GATs, benefiting over 10,000 users.

The top three players in the individual points ranking were occupied by players from China, Ukraine, and Singapore, who won 1 BTC, 5,000 USDT, and 3,000 USDT respectively as superb prizes.

The domiciles of players ranked from 4 to 10 cover countries or regions such as Russia, the UK, Hong Kong, China, and Singapore, and they all received 1,000 USDT.

For more information on AEX, please check out their official website.

Disclaimer: This is a paid post and should not be treated as news/advice.

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AEX celebrates its 8th anniversary with 'Texas Hold'em Poker' competition - AMBCrypto News

The Time Is (Still) Now For Change In The Poker Hall of Fame – PocketFives

I also wanted to say that there are so many deserving nominees who have worked hard to earn a place in the Hall of Fame. More and more great players and builders are starting to turn 40 years old. I really hope that the World Series of Poker begins to induct a couple more nominees each year. Eli Elezra, 2021 Poker Hall of Fame inductee.

For the second year in a row, just a single person was inducted into the Poker Hall of Fame. This year, it was Eli Elezra, noted high-stakes cash game pro and four-time WSOP bracelet winner. By all accounts, for his contribution and achievements in the game, Elezras inclusion in the Hall is well deserved. But in his brief speech in the Brazilia Room, after thanking his mentors and recounting his journey, Elezra took a moment to acknowledge the other deserving nominees with a hope that they, like him, may also have the opportunity to be so honored.

Its a hope thats shared by many who follow the Poker Hall of Fame. In 2020, it came a bit of a surprise that the PHOF opted to reduce the already low number of two inductees to a single person, citing a return to the Poker Hall of Fames roots and the benefit of time as reasons to keep the election process as elite as it is.

We like tradition, WSOP Executive Director Ty Stewart said in 2020. One per year is the way it was for the majority of the Poker Hall of Fames history. A single inductee seems to promote the prestige of the honor. Most of the finalists these past few years are very young men. I would hope and assume they will all get inducted eventually.

What a difference a year makes. Even when the voting process allowed for two persons per year, the thought that the bottleneck of bringing valued figures of poker into the Hall of Fame was not ready for the flood of future poker greats, inspired by the poker boom.

Looking ahead, without change, the Poker Hall of Fame may keep its elitist status but will forgo its credibility. A Hall of Fame isnt about the number of people in it, its about accomplishments. And nearly two decades after a poker explosion extended the love for the game around the world, continuing to cut off more-than-deserving players and builders, makes the Hall look and feel like an old-school popularity contest rather than a celebration of those who have made the game great.

That point has never been better illustrated than this year at the 2021 World Series of Poker when players, far younger than the 40 year age requirement, have added bracelets to their resume that reflect the numbers that, as of right now, are part of a legitimate Hall of Fame career.

Take a look at the accomplishments of Shaun Deeb, Brian Hastings, and Brian Rast, all three of which earned their fifth career bracelet this fall. Rast, who will turn 40 before the next Hall of Fame nomination process, has made it well-known that the Hall of Fame is on his radar as what he expects to be his next accomplishment and will most certainly be considered next year.

Really, the number one thing at this point is kind of just making the Poker Hall of Fame. I mean, I feel like, I think Ive done enough in my career Rast said immediately after his fifth win. And hes not out of line in that thinking. In addition to collecting bracelets, Rast also has more than $22 million in live career tournament earnings, good for 24th on the All-Time Money List, and has been known to play cash games at some of the highest stakes available.

Those three five-time bracelet winners are followed closely by a swarm of top-tier names, all of whom earned their fourth this series. Adrian Mateos, Ben Yu, Anthony Zinno, Brian Yoon, John Monnette, Benny Glaser, Farzad Bonyadi, Adam Friedman, Kevin Gerhart, and 2021 WSOP Player of the Year Josh Arieh all have great cases for future consideration. The four-time bracelet winner club increased by 33% in just one series and, coincidentally, its the same number of bracelets that Eli Elezra has to his credit upon induction.

Of course, bracelets alone are by no means the only criteria for being inducted, but they do play a big role. Currently, respect at the highest stakes and, honestly, popularity among the 32 living members of the Hall of Fame (or those who have the most influence within that group) is perhaps even more important under the current system. But with that said, its clear that not only is there incredible talent on the rise, but the bar for what its going to take in the future to not only get nominated but get elected is also climbing higher.

With so much talent rising and becoming eligible over the next five years two things are clear: the first is that the time for the Poker Hall of Fame to adapt to how much bigger the game of poker is today is here. In fact, its been here. Also, secondly, should the Hall not adapt, people who were once thought to be a lock for the Hall of Fame one day will be frozen out far longer than they deserve to be due to the pressure of escalating poker resume requirements to be considered by the public for the nomination process as well as for the voters themselves.

For example, take a look at the case for Mike The Mouth Matusow. Matusows resume looks incredibly close to that of Elezras in terms of his bracelet count and his time spent on poker television. It wouldnt be tough to argue that, in terms of notoriety, Matusows influence on the game of poker far outshines many of the more recent inductees. His brash, polarizing personality has been ever-present on the poker landscape since the early 2000s, and, like him or not, hes been an ambassador for the everyman and a persistent presence on poker television.

But at 53 years old, Matusow doesnt appear to be any closer to an induction into the Hall today from the day he became eligible. In 2020, when the votes cast were made public, Matusow received the third-lowest total votes. Perhaps its because the mouth hes so famous for is a turn-off for those casting the votes. But as Hall of Famer Daniel Negreanu has said many times the Poker Hall of Fame isnt designated for just the nice guys.

If it were, well Matt Savage wouldnt still be waiting. But even after his sixth nomination, Savage one of the most influential tournament directors in the game is still on the sidelines and, like Matusow, will soon be facing the robust resumes of elite players. But hes also contending with the perceived notion that, if theres only one spot open, its best not to use it for a builder or someone who has simply advanced the game as opposed to someone who crushes in it.

To further that point, it seemed like when PokerStars founder Isai Scheinberg was first nominated in 2020 he would be a first-ballot Hall of Famer. He, along with his son Mark, took online poker to the masses, helped amplify the Moneymaker effect, and not for nothing was the architect to bail out thousands of players from the implosion of Full Tilt Poker (something that likely keeps surefire Hall of Fame member Chris Ferguson on the outside, perhaps never to get in). But Scheinberg, even after clearing up all legal ramifications in regards to Black Friday, is not only not a first ballot member, hes now been passed over twice.

Its easy to see a few of these names and, perhaps, argue that they actually dont belong. That what they have contributed or achieved doesnt warrant inclusion. But its hard to ignore that the impact of poker on the worldwide community is also not well-reflected in the Hall of Fame. Recent nominees including Chris Bjorn, Thor Hansen, and Bruno Fitoussi all deserve another look for their contributions to poker.

The end result is a Poker Hall of Fame that looks trapped in time and out of touch with modern poker. But heres the hope moving forward: as the World Series of Poker leaves the Rio and begins a new era on the strip, perhaps there is a new era of change for the Poker Hall of Fame on the horizon. Not one that loosens the requirements by any means, but, as Elezra said in his speech, acknowledges that there are many deserving people from both the player and builder category who deserve to have the doors of the Hall open while they still around to enjoy being a part of it.

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The Time Is (Still) Now For Change In The Poker Hall of Fame - PocketFives

October Online Poker Revenue Remains Steady in PA and NJ, Online Gambling Revenues Soar – CardsChat.com

While gambling revenue in Pennsylvania continues to soar, online poker is hanging steady in the gambling slipstream.

According to the Pennsylvania Gaming Control Boards report for October, gambling revenues hit a record-high of $425,916,762, beating the watermark set in July by $3 million.

Out of that, the four online poker rooms pulled in $2.8 million, a blip down from $2.92 million they generated in September.

BetMGM and Borgata, which operate using PartyPokers software, saw slight increases while WSOP and PokerStars revenue slightly declined from September.

The WSOPs October revenue was affected by unmet guarantees in more than a dozen tournaments spread in its Fall Online Championship Series. The shortfalls forced the operator to add more than $285K to prize pools throughout the month. The same series also ran on WSOP.com in New Jersey and Nevada, which share player pools with one another, and whose tournaments met all but one of their guarantees.

Its the third full month with all four poker rooms operating. PokerStars had a monopoly from November 2019 until Borgata and BetMGM went live in the Spring this year, followed by WSOP in July.

After gambling revenue surpassed the $400 million mark in July, Pennsylvania Gaming Control Board Executive Director Kevin OToole said he expects the trend to continue thanks to online table games and slots, which passed $70 million in revenue itself.

The online gaming revenue total for October, which includes online poker but not online sportsbooks, hit $103 million across 10 casinos a 72% increase compared to October 2020. Four brick-and-mortar casinos are partners with the states online poker sites, including Hollywood Casino at Penn National, which partners with BetMGM, Rivers Casino, which partners with Borgata, Mt. Airy whos partnered with PokerStars, and Harrahs, which is partners with WSOP.com.

The states gaming report outlines how online gambling has been a goldmine for these casinos, particularly Hollywood Casino, which pulled in $20 million in October; only $303K of that revenue came from online poker, however. Rivers online revenue is second in the state at $26 million, but only $108K of those monies came from online poker.

Mt. Airy generated $5.3 million in online gambling revenue, of which $1.8 million came from PokerStars. Harrahs generated $2.6 million in online revenue in October, of which, $587K came from poker.

Like its neighbor to the West, New Jersey saw a slight dip in poker revenue in October, taking in $2.4 million throughout the month, which is $100K less than the state booked in September. Even so, the states revenue remains steady for the year, according to the New Jersey Division of Gaming Enforcements iGaming report for October.

After cracking the $1 million revenue mark in September, BetMGM/Borgata took the biggest step back, falling $88K short of its September number. Only WSOP, possibly thanks to the online bracelet events that ran on Sundays throughout the month, made slight gains.

Including online poker, online gambling revenue for October was $127 million, up $5 million from September. The statestotal gross fromgambling was $448.7 million.The casinos doing a booming business with their online table games and slots, while online poker remains a niche offering.

Resorts Digital Gaming, which partners with PokerStars, pulled in $29 million in online gambling revenue for October, with just $623K of that coming from poker. For Caesars/WSOP.com, total online revenue was $8 million, with just about 10% coming from poker. Meanwhile, Borgatas online gambling revenue tally hit nearly $39 million, with only $933K coming from poker.

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Bob Pajich

Bob Pajich is a poker news reporter, creative writer, and poker player who never met suited connectors he didn't like.

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October Online Poker Revenue Remains Steady in PA and NJ, Online Gambling Revenues Soar - CardsChat.com

Police probe ‘strip poker’ footage of cops after officers filmed in flat without consent – Scottish Daily Record

Police Scotland have launched a probe after footage of serving officers allegedly playing a game of strip poker has been circulated online.

The vile video, which was taken without the consent of those involved, is said to have been filmed in the quiet town of Campbeltown, Argyll, on Monday night.

Footage seen by the Daily Record appears to show the group, involving three male cops and one female within a private flat as they are filmed from another property across the street.

It has been shared widely on social media with those who filmed it claiming the cops were performing 'sex acts'.

But a source close to the investigation told the Record it was a game of strip poker after a night of drinking and that those who have filmed it could now be on the wrong side of the law.

The source said: "Whatever you think about what the officers were doing, they were behind closed doors, in a private home, and were all consenting participants in what went on.

"They didn't consent to being filmed. They couldn't, as they didn't even know it was happening.

"Recording people in intimate situations without their consent is a criminal offence and can carry a jail term.

"It's also against the law to share or distribute this illegally obtained footage.

"Whoever is responsible for filming and sharing the video should be worried, they're probably going to be facing at least two charges when the case gets to court."

Recording people without their knowledge or consent is a crime under under Sections 9(1) and (4) of the Sexual Offences (Scotland) Act 2009.

Disclosure of an intimate photograph or film is also a crime under Section 1 (2) of the Abusive Behaviour and Sexual Harm (Scotland) Act 2016.

No police officers have been suspended.

A Police Scotland spokesperson said that the probe was at an early stage.

She said: "We are aware of reports of mobile phone footage being shared online. Enquiries are at an early stage."

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Police probe 'strip poker' footage of cops after officers filmed in flat without consent - Scottish Daily Record

The EndBoss Takes It All – MIT Grad Ishaan Chugh Reveals What Its Like To Win Pokers Top Spot! – News18

Last couple of months have been captivating for the Indian sports fans with back-to-back cricketing action. Whats more interesting is the fact that how Indians are opening to various categories of sports. One of the rising stars in that segment is the mind sports of Poker. It enjoys a wide following across western countries including US, UK, Canada, Germany, Spain, and France. Poker is fast picking up in India and has seen an exponential growth in the last few years. Given the rising popularity of the game, Poker tournaments have become a regular offering on various poker platforms. However, there is one tournament that stands out in creating massive buzz amongst the online gamers.

Bringing true justice to its name, the EndBoss is Indias single biggest poker tournament by far and offers a staggering prize of 5 Crore. Introduced in the year 2020, the first edition of EndBoss saw Pune based Abhishek Maheshwari clinching the title.

The much-anticipated 2021 edition of the tournament kicked off on October 20th. 31-year-old Delhi-based MIT graduate Ishaan Chugh came triumphant over 4,816 entries.

While the Massachusetts Institute of Technology (MIT) alumni has been playing poker since 2008, Ishaan feels special about this win which also awarded him a prize amount of 70 Lakh.

70-Lakh is no small amount. So, I am thrilled!" said Chugh, ecstatic about his competition-smashing victory. So, if youre thinking, what were the chances?, Chugh provides some insight. He attributes his success to his strategy of focusing on the hand in front of him, avoiding emotional decisions, and navigating game fatigue well. While I did my best to avoid the tough spots, things worked out, and the right cards fell my way," he adds.

Talking about his origin story in an interview with Poker commentator Aditya Wadhwani, Chugh shares that his brother introduced him to poker in 2008. He says he started playing for fun before upping the challenge to playing for real money online and playing with other friends from MIT."

He reveals how his experience playing across different circles gave him insight into how other people play and how small decision calls can add up throughout the game. The EndBoss witnessed more than 4800 entries across five qualifying rounds, but only about 600 players made the cut and continued on to the final, also known as Day 2.

Currently estimated at 400-Crore, the online poker industry is only set to skyrocket in the next five years. According to the estimates by KPMG, the Indian online gaming enterprise is projected to develop at a CAGR of 22 % to attain 11,880 Cr by 2023, making it a lucrative front runner in the race for top new sources of revenue.

The EndBoss tournament is hosted by PokerBaazi.com, an indigenous platform that leads the Indian poker industry today. The platform, known for its award winning mobile app, available for Android and iOS, has been a key accelerator in the poker space. It is also accredited for hosting Indias flagship poker series, the National Poker Series. Platforms like these and inspiring stories of people like Chugh will be influential in taking Poker to a larger space in India.

This is a partnered post.

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The EndBoss Takes It All - MIT Grad Ishaan Chugh Reveals What Its Like To Win Pokers Top Spot! - News18

Xiaomi Read Mode: tricks to get the most out of it – InTallaght

Xiaomi always tries to surprise users, especially with different tricks and settings that they can use on their mobiles.

It goes without saying that MIUI is one of the most complete and capable customization layers in terms of Android devices, and today you will learn about a special function called Read Mode, in addition to some special tricks to get the most out of it.

Speaking fully about this tool, it is a configuration designed to cause the least possible effect of visual fatigue when using the mobile. This is especially applicable to situations where dark environments and during night hours.

This is something that, without a doubt, will benefit those who expose themselves for long periods to the light of the screen, which can be detrimental to visual health in the medium and long term. So then, below you will see the steps to activate the aforementioned function, as well as some tricks that you can configure later.

Enter the application Setting. In the third block of apps, look for the one of Screen. Access the second option that says Reading mode. Activate the function.

Now, the extra tools come within the option of Program, located one box below. By activating it, you will be able to access both the Night reading, such as Customize the schedule, leaving specific hours in which you want the function is activated and deactivated.

In addition to these settings, you can also manage a slider bar at the bottom of the window, which adjust the intensity of the filter which is applied when the reading mode is active. Keep in mind that a higher intensity of it will give less mental fatigue when viewing the screen, although this could make the interface less realistic.

Finally, another trick that can make it easier for you to activate the function, goes through add your quick access to the drop-down bar of settings. You can achieve it in less than a minute if you do this:

Unfold your bar Quick Settings, sliding your finger down. Find and click on the box that indicates Edit.

Among the options that are shown to you, locate the function of Reading mode, press and hold its icon and then upload it with all the others.

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Xiaomi Read Mode: tricks to get the most out of it - InTallaght

Party will use a special app to manage the MCD Badlaav Campaign: Gopal Rai – News Nation

New Delhi :

With the MCD elections around the corner, the Aam Aadmi Party is preparing for a large-scale MCD Badlaav Campaign which will be launched on 2nd December, Party State Convenor Gopal Rai informed. Different responsibilities have been assigned to the office-bearers of the party for this. The preparations for the Badlaav campaign started on 27th November.

A special app will be used to upload all the campaign details. Gopal Rai added that an in-charge would be appointed in each division who would be responsible for conducting the MCD Badlaav Campaign. On 5th December, teams in every division of Delhi will launch the MCD Badlaav Campaign at the ground level by placing tables. AAP National Secretary Pankaj Gupta said that their main aim is to have at least one in-charge in every division. Senior Aam Aadmi Party leader Gopal Rai addressed a virtual meeting on Friday. He said, In view of the MCD elections, we are going to launch a big membership drive soon.

In this MCD Badlaav Campaign, we will upload the data through a special app to streamline the data and for efficient work. The training for this app will be given by Pankaj Gupta Ji, Adil Ji, and Anuj Ji at the party office on November 27. Yesterday, the district teams of the Partys State Organisation, observers, and the speaker and organization ministers from each assembly were trained at the party office on how to carry the MCD Badlaav Campaign forward. He continued, For 4 days, between 28th November to 1st December, a planning meeting in all the Vidhan Sabha will be fixed by every Lok Sabha and District Presidents.

Meetings will be held after discussion with the MLAs and other people present there. Two things have to be completed in that meeting. One, about who will be in charge of the change campaign from each of our Mandals. When I am talking about the in-charge, it is to be kept in mind that this post will be in addition to the Mandal President. They could be an office-bearer of the Legislative Assembly or a ward-level office-bearer or a Vidhansabha-level office-bearer of the Centre.

Two, those who are our responsible colleagues, who are working in other positions, also have to be made in charge of the board. Their responsibility is to successfully complete the MCD change campaign. Giving more information about the launch of MCD Badlaav Campaign, Gopal Rai said, Everyone will be given complete training on the app, how to operate the app and how to upload the data on it in a meeting. These meetings will be held on 28th, 29th, 30th, and 1st. On 2nd December, we will launch this at the Central level. In this, everyone from the high-level people to the Mandal President will be called to the party office. So by calling all those people who are in charge of the Mandals and those who are becoming Mandal President, we will launch this MCD Badlaav Campaign before the central media on 2nd December.

After this, on December 5, our desks will be set up in every Mandal. If 5th is a Sunday, then on that day in every division of Delhi, our teams will launch this change campaign at the ground level by setting up desks. He continued, At the launch, all the party members, all the MLAs, all the councilors, all the frontal office-bearers, wherever they are, will be taking up their responsibilities in the campaign and playing their respective roles.

They will get the design of posters and hoardings before the central launch on the 2nd and our outdoor campaign to put up posters and hoardings in all the Legislative Assemblies will be completed before the 2nd day. So in this, we will add new members. After the MCD Badlaav Campaign, all the organization ministers will meet the new members of MCD Badlaav Campaign booth-wise and give them responsibility so that those people can also become a part of our organization active in this.

He said, This is a major campaign, so we want every booth to have at least 4-5 lanes, so we have to decide through this MCD Badlaav Campaign that we have at least 8-10 people in every street. These people will further our campaign and its awareness in their respective streets, to ensure good connectivity. We will try to recognise our correct and potential new members. They can be identified according to the streets.

So that later we will be able to make them the organization officers at the level of that street through which we will conduct further activities. AAP National Secretary Pankaj Gupta said, As Gopal Ji said that we have to reach every street, every gully, and our effort is to ensure that enough people take charge and be appointed to oversee the efforts. We have to add so many people that there are about 50 names on every page in every booth.

Out of them at least two people should be the ones to whom we can give responsibility. This is our aim. This time we will go ahead keeping this in mind because every time we try to access different divisions, booths get blocked. That's why Arvind Ji has given a special responsibility that we can go beyond the booth to reach even smaller groups of people. We will come up with a good name for that too. You have to take responsibility to think of a name.

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Party will use a special app to manage the MCD Badlaav Campaign: Gopal Rai - News Nation

Events for children, teens, adults at the library – The Herald-Times

Monroe County Public Library provides opportunities for local residents to read, learn, connect and create. The downtown library is at 303 E. Kirkwood Ave. and the Ellettsville branch is at 600 W. Temperance St. All events are free of charge. Event funding is provided by the Friends of the Library foundation.

Curious about the Ellettsville Teen Space, but you arent a teen? Patrons of all ages are invited to check it out on the fourth Saturday of every month there's a DIY design studio, video games, virtual reality, and more! Its noon-6 p.m. Saturday at the Ellettsville branch library.

Discover why yoga is such a powerful tool for keeping you healthy in body, mindand spirit! In this all-levels class, beginners safely learn the basics, while more experienced students take their practice to a deeper level. This event is suitable for people of all ages and most physical abilities. For ages 16 and up. Its noon-1 p.m. Saturday in meeting room B at the Ellettsville Branch Library. Please register at mcpl.info/calendar.

Join Maqub Reese, founder and CEO of Tribe Consulting, LLC and associate director for the Kelley Office of Diversity Initiatives, to explore your identities and learn what it means to be anti-racist during this engaging interactive workshop. You'll also learn about racial literacy, and global, national and local leaders who are Black, Indigenous andothe people of color and their intersections. For ages 7-12. Its 1-3 p.m. Saturday in meeting room 1B and 1C combo at the downtown library. Register at mcpl.info/calendar.

Join the library staff as they create a safe space to discuss books written by and for LGBTQ+ individuals. In November and December, youll discuss "We Do This 'Til We Free Us: Abolitionist Organizing and Transforming Justice," by Mariame Kaba. Its 6-7 p.m. Monday on Zoom. For ages 16 and older. Register for the Zoom link and book by emailing Linds Badger at lindsey@middlewayhouse.org.

Books on Tap is the book club with a twist! Enjoy fantastic drinks, a comfortable atmosphereand great discussion on a compelling book. Each registered participant will receive a drink recipe that goes with the months book selection. This months selection is Binti by Nnedi Okorafor, winner of the Hugo Award and the Nebula Award for best novella! For ages 21 and older. Its 6:30-8 p.m. Monday on Zoom Register at mcpl.info/calendar for the Zoom link and a copy of the book (if you need one). November and December will also include discussion on what types of books you want to read in 2022 make sure to attend if you want to influence the book selections. Visit mcpl.info/bookclub for other book clubs and titles.

Drop in for free one-on-one help with math and science-related assignments arithmetic,algebra, geometry, trigonometry, calculus, physics, chemistryand ISTEP and SAT review. For middle school and high school students only. Its 7-8:45 p.m. Monday in program room 2B at the downtown library.

Join in the fun with stories, songs, puppets and more to encourage the development of early literacy skills in young children, using the guidelines from the Every Child Ready to Read program. For ages 3-6 and caregivers, but all are welcome. Its 10-10:45 a.m. Tuesday in the childrens program room at the main library. Register at mcpl.info/calendar.

Come to chat about relationships, dating, and other tough topics, stay for the tacos! For ages 12-19. Its 4-5 p.m. Tuesday in Ellettsville meeting room a. Drop in.

Using 3D-modeling software (like the free and user-friendly Tinkercad), you can turn digital designs into real-world physical objects come design your own keychain! The library will guide you through the creative process, then print it! For ages 12-19. Its 4-5 p.m. Tuesday in The Ground Floor teen space at the downtown library. Drop in. Please note, 3D printing takes time you will need to return to the library at a later date to pick up your creation. Single color prints only.

Prenatal yoga is a gentle exercise that supports your changing body's needs, builds strengthand deepens awareness of your mind, body, and connection with your baby. For pregnant adults. Its 7-8 p.m. Tuesday in the childrens program room at the downtown library. Register at mcpl.info/calendar.

Create an original one-page comic to share with the community and enter to win one of 20 gift cards to Vintage Phoenix Comic Books! Categories are available for kids ages 7-11 and teens ages 12-19. Upload your comic to mcpl.info/comic by Tuesdayto enter the contest! Please note: All comics must be appropriate for all ages comics that do not meet this guideline will not be shared.

Families with kids from infants to age 3 can play, sing, read and talk together with other little ones then enjoy toy time. Its 9:30-10:15 a.m. (birth-18 months) and 10:30-11:15 a.m. (18 months-3 years) Wednesday in the childrens program room at the downtown library. Register at mcpl.info/calendar.

Drop in, adventure through fantastic realms, then leave when you want! These sessions of Dungeons and Dragons are designed to be short, fun, and evolving adventures that anyone can play. All skill levels are welcome! For ages 12-19. Its 4-5 p.m. Wednesday in meeting room 1Bat the downtown library.

Give back to the library by shopping at the bookstore! All movies and music at the Friends of the Library Bookstore are half price in November. The sale includes DVDs, CDs, LPs, tapes, and Blu-Rays. The Bookstore also offers unique gifts for library supporters, including masks, T-shirts, notecards, tote bags, and more! The bookstore is open 11 a.m.-7 p.m. Tuesday and Thursday; 11 a.m.-5 p.m. Friday and Saturday; and 1 p.m.-5 p.m. Sunday. Visit mcpl.info/bookstore for more information.

This is a sampling of this weeks library events. For the full calendar, visit mcpl.info/events.

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Events for children, teens, adults at the library - The Herald-Times

The global genome editing/genome engineering market is expected to reach USD 11.7 billion by 2026 from USD 5.1 billion in 2021, at a CAGR of 18.2% -…

during the forecast period. The growth of the genome editing/genome engineering market is expected to be driven by the rise in government funding and growth in the number of genomics projects, increased application areas of genomics, and the introduction of CRISPR-Cas9 for genome engineering.

New York, Nov. 25, 2021 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Genome Editing/Genome Engineering Market by Technology, Product & Service, Application, End user - Global Forecast to 2026" - https://www.reportlinker.com/p05220258/?utm_source=GNW

The services segment accounted for the highest growth rate in the genome editing/genome engineering market, by product & service, during the forecast periodIn 2020, the services segment accounted for the highest growth rate.The genomic editing/genome engineering services market is segmented into sequencing services; data analysis; bioinformatics services; and other services, such as informatics, clean up, gene expression, and DNA synthesis services.

Most companies in the services sector offer all these services.Although the services segment represents a major part of the market, some end users have in-house sequencing and bioinformatics capabilities.

Service providers possess highly advanced and multiple sequencing platforms and make use of high-quality consumables/kits. They also have multiple sequencing platforms, which enables these service providers to choose the most appropriate system to solve the scientific challenges of their customers and promptly deliver high-quality sequencing at a low cost.

The CRISPR segment accounted for the largest share of the application segment, by technology, in the genome editing/genome engineeringIn 2020, the CRISPR technology accounted for the largest share.Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is a revolutionary tool used to edit genes in a way that resembles traditional GMO techniques.

The use of the Cas9 enzymes differentiates CRISPR from other forms of genetic modification.The ease of use associated with CRISPR technology gives it a significant advantage over ZFN and TALEN, especially in generating a large set of vectors to target numerous sites or even genome-wide libraries.

Another potential advantage of CRISPR is its ability to use multiple guide RNA parallelly to target multiple sites simultaneously in the same cell. This makes it easier to mutate multiple genes at once or engineer precise deletions in a genomic region.

Asia Pacific: The fastest-growing region in the genome editing/genome engineering marketThe genome editing/genome engineering market is segmented into North America, Europe, Asia Pacific, Latin America (LATAM) and Middle East and Africa (MEA). Increasing government support, and developing R&D infrastructure Increasing investments in research and rising number of applications of gene synthesis for genetic engineering of cells and tissues of organisms are the major factors fueling the growth of the genome editing/genome engineering market in the Asia Pacific region.

The primary interviews conducted for this report can be categorized as follows: By Respondent: Supply Side- 70% and Demand Side 30% By Designation: C-level - 55%, D-level - 20%, and Others - 25% By Region: North America -50%, Europe -20%, Asia-Pacific -20%, RoW -10%

List of Companies Profiled in the Report: Thermo Fisher Scientific (US) Merck KGaA (Germany) GenScript China) Sangamo Therapeutics (US) Lonza (Switzerland) Editas medicine (US) CRISPR Therapeutics Tecan Life sciences (Switzerland) Precision biosciences (US) Agilent technologies (Switzerland) PerkinElmer (US) Cellectis SA (France) Intellia Therapeutics (US) Bluebird Bio (US) Regeneron Pharmaceuticals (US) Synthego (US) Vigene Biosciences (US) Beam Therapeutics (US) Integrated DNA Technologies (US) New England Biolabs (US) Origene Technologies (US) Transposagen Biopharmaceuticals (US) Creative Biogene (US) Recombinetics (US) Caribou Biosciences (US)

Research Coverage:This report provides a detailed picture of the genome editing/genome engineering market.It aims at estimating the size and future growth potential of the market across different segments such as the product, application, end user and region.

The report also includes an in-depth competitive analysis of the key market players along with their company profiles recent developments and key market strategies.

Key Benefits of Buying the Report:The report will help market leaders/new entrants by providing them with the closest approximations of the revenue numbers for the overall genome editing/genome engineering market and its subsegments.It will also help stakeholders better understand the competitive landscape and gain more insights to better position their business and make suitable go-to-market strategies.

This report will enable stakeholders to understand the markets pulse and provide them with information on the key market drivers, restraints, challenges, trends, and opportunities.Read the full report: https://www.reportlinker.com/p05220258/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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The global genome editing/genome engineering market is expected to reach USD 11.7 billion by 2026 from USD 5.1 billion in 2021, at a CAGR of 18.2% -...

With this New Technology, 3D Printing Comes to Life Literally. – News @ Northeastern – News@Northeastern

If humans are to live on Mars or the moon one day, well need to be able to construct buildings to live, sleep, eat, and work in space. The way to do that, space agencies have said, is to 3D-print habitats or their components. But hauling enough of the Earth-derived materials used for most 3D printing from our planet to another celestial body isnt a feasible option.

Biology could solve that problem, says Neel Joshi, associate professor of chemistry and chemical biology at Northeastern. And Joshis team may have devised just the technology for the job: a 3D-printable material that is alive.

Like a tree has cells embedded within it and it goes from a seed to a tree by assimilating resources from its surroundings in order to enact these structure-building programs, what we want to do is a similar thing, but where we provide those programs in the form of DNA that we write and genetic engineering, Joshi says.

The researchers have figured out how to program the bacterium Escherichia coli, also known as E. coli, to produce an entirely biological ink which can be used to 3D-print solid structures. That microbial ink, which is described in a paper published Tuesday in the journal Nature Communications, has yet to be tested on a cosmic scale, but the scientists have used the gelatinous material to print small shapes, such as a circle, a square, and a cone. They have also successfully programmed it to build materials with specified attributes with other applications that could be useful in medicine.

Neel Joshi, associate professor of chemistry and chemical biology, works on programmable microbial ink for 3D printing of living materials, in the Mugar Life Sciences building. Photos by Matthew Modoono/Northeastern University

We want to use living cells, microbes, as factories to make useful materials, says Avinash Manjula-Basavanna, a postdoctoral fellow in Joshis laboratory and co-lead author on the new paper. The idea, he says, is to harness the properties that are unique to the materials that make up living things for a spectrum of purposes, ranging from therapeutic to industrial.

Think about it as a platform for building many different things, not just bricks for building buildings or construction, Joshi says. He explains the work by comparing it to the way a polymer chemist considers how to devise plastic materials that can serve distinct purposes. Some plastics are hard and retain their shape, while others are stretchy and soft.

Biology is able to do similar things, Joshi says. Think about the difference between hair, which is flexible, and horns on a deer or a rhino or something. Theyre made of similar materials, but they have very different functions. Biology has figured out how to tune those mechanical properties using a limited set of building blocks.

The particular natural building block the scientists are taking advantage of is a protein produced by the bacterium E. coli. The material, called Curli fibers, is produced by the bacterial cells as they attach to a surface and to one another to form a community. The same properties that make the Curli fibers a sort of glue for the bacteria also make it an attractive material for microbial engineers like Joshi and his colleagues.

The researchers 3D-printed small shapes using the microbial ink that they developed from the bacterium Escherichia coli, also known as E. coli. Image courtesy of Duraj-Thatte et al., Nature Communications

To make the microbial link, the scientists started by culturing genetically engineered E. coli in a flask. They fed the bacteria nutrients so that they would multiply, and as they divided they would produce the desired polymers, the Curli fibers. Then, the researchers filtered out the gelatinous polymers and fed that material into a 3D printing apparatus as the microbial ink.

Microbes have been used to make the ink for 3D printing before, but, Joshi and Manjula-Basavanna say, what sets this microbial ink apart is that it is not blended with anything else. Their gel is entirely biological.

One of the perks of a truly living material is that it is, in fact, alive, Manjula-Basavanna says. And that means that it can do what living things can do, such as heal itself, the way skin does. In the right conditions, the cells in the microbial gel could simply make more of itself.

Its not necessarily always growing, Joshi says. For example, if the cells were left alive in the small cone that the team made from the microbial gel, if you were to take that whole cone and dunk it into some glucose solution, the cells would eat that glucose and they would make more of that fiber and grow the cone into something bigger, he says. There is the option to leverage the fact that there are living cells there. But you can also just kill the cells and use it as an inert material.

While the initial gel is made entirely from genetically engineered E. coli, the researchers also tried mixing the ink with other genetically engineered microbes with the goal of using the 3D-printed materials for specific purposes. Thats how they made a material that could deliver an anticancer drug, which it released when it encountered a specific chemical stimulus. In another experiment, they also programmed another material to trap the toxic chemical Bisphenol A (BPA) when it encountered BPA in the environment.

You could think about taking a bottle cap and printing our material on the inside of it so that if there was BPA around, it would be sucked up by that and not be in your drink, Joshi says.

This study was simply a proof-of-concept endeavor, but Joshi sees this microbial ink as opening a door to all kinds of possibilities for building things with biology.

If there is a way to manufacture in a more sustainable manner, its going to involve using living cells, he says. This is advancing more towards that type of paradigm of building things with living cells.

For media inquiries, please contact Marirose Sartoretto at m.sartoretto@northeastern.edu or 617-373-5718.

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With this New Technology, 3D Printing Comes to Life Literally. - News @ Northeastern - News@Northeastern

You Should Be Afraid of the Next Lab Leak – The New York Times

I asked Davey, as well as Elke Mhlberger, another researcher at NEIDL, if they were ever fearful. Once they became comfortable with the pressurized suits, they said, they experienced a kind of joy in the privileges of the work, as well as confidence in containment measures. To Mhlberger, in fact, working in a Level 2 or Level 3 facility feels riskier than being in a Level 4 lab, where the safety protocol is so stringent; the day before she gave birth to her second son, she told me, she spent the morning working with the Ebola virus in a Level 4 lab. Once inside, there are no cellphones, no email, no small talk only the pathogens and the white noise of air swirling around her ears. Its really very relaxing, she said. Her work is focused on the planets most formidable threats, she acknowledged. But it is in many ways an escape from the world itself.

Is that world better off with or without high-containment biolabs? Its a question not easily resolved. The work that goes on inside them involves a nontrivial degree of risk, which is why NEIDL, with its vaults and barricades and bulwarks including its operational protocols resembles a modern-day citadel. Yet no amount of engineering, infrastructural or human, can reduce to zero the chance of bad things coming out of biolabs. On the other hand, without them, we would lack all sorts of treatments for diseases like Covid-19 and Ebola. For now, the world seems to agree that we need these facilities.

Next summer, the C.D.C. will break ground on a new high-containment laboratory complex on its campus in Atlanta. One ambition is to supplement an aging biolab with a five-story, state-of-the-art facility that includes two Level 3 suites and six Level 4 suites. These will be largely dedicated to studying viruses with more fearsome fatality rates: Ebola, Nipah, Marburg, Chapare. Construction will take about three years, followed by a two-year commissioning process to ensure safety expectations are met. The cost has been reported to be at least $350 million a significant jump from the $280 million (adjusted for inflation) that built the NEIDL facilities. Melissa Pearce, who will oversee the new lab, told me that she and her C.D.C. colleagues have toured North American facilities in recent years to survey current best practices and design ideas.

Ideas that are too new wont necessarily be adopted. When youre designing a Biosafety Level 4, the thought of using new technology tends to give you pause, Pearce told me. Its like the first year of a brand-new model of a car you tend to not want to buy that, because there are probably some bugs that need to get worked out. So, many of the improvements in Atlanta are likely to be incremental. Some of the researchers on the planning team believe that the spaces in current Level 4 labs are too narrow, for example, so there will be more room within new suites for workers to move around freely. A new chemical shower off the hallway will allow the staff to sanitize equipment more efficiently.

To talk to people at the C.D.C. is to be struck by how close to the next pandemic they think we might be and how important, should a little-known infectious agent again explode in the general population, the research done on exotic viruses in containment there and elsewhere will be in directing us toward therapies or a cure. Thats the expectation at NEIDL, too, where Mhlberger has recently been working with the Lloviu virus, a relative of Ebola, which was first identified in bats in Eastern Europe 10 years ago. A group in rural Hungary extracts small amounts of blood from local bat colonies, searching for Lloviu. If the virus is present, the group sequences and sends the genetic information to her. She then compares its viral properties with other pathogens to better understand potential dangers. We dont know yet whether it causes disease in humans or not, she said. But if it causes disease, about 200 million people live in the area where these bats roam.

When I asked Joel Montgomery, the head of the viral special pathogens branch at the C.D.C., whether our awareness of new pathogens is a result of improved surveillance or of more viruses having increased opportunities to jump into humans, he seemed to think both factors were responsible. The ability to test new viruses, thanks to nucleic-acid-sequencing capabilities, is far better than it was 10 or 20 years ago. But I think we are interacting with our environment much more now than we have before, and just the sheer number of people on the planet has increased, he said, which also affects population densities. And so were going to see outbreaks epidemics, pandemics happening more frequently. It most certainly will happen.

Our high-containment facilities, moreover, may have to deal with threats hatched in labs as well as what comes from nature. Take, for example, pox diseases. The C.D.C.s campus in Atlanta is home to one of two Level 4 labs left in the world that harbors the live variola virus, which causes smallpox and was declared eradicated globally in 1980. (The other cache is in Russia.) Victoria Olson, a deputy director of lab science and safety at the C.D.C., told me that the lab keeps samples because studies using a live virus could help scientists develop diagnostics, treatments and vaccines should smallpox re-emerge, or should a similar poxvirus appear. Monkey pox, which has caused recent outbreaks in Africa, where it has a fatality rate of 10 percent, is already a serious concern; Alaska pox was just identified in 2015. More alarming, perhaps, is the potential that someone outside the world of known biolabs might cook up a version of a poxvirus, using the tools of genetic engineering. Smallpox had an average case-fatality rate of about 30 percent; Americans have not been immunized against it since 1972. A synthetic smallpox or even a synthetic super smallpox, which could be deadlier than the original is not much of an intellectual leap.

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You Should Be Afraid of the Next Lab Leak - The New York Times

Global Cell Therapy Markets Report 2021-2030: Cell Therapy Markets According to Therapeutic Areas, Technologies, & Companies – PRNewswire

DUBLIN, Nov. 24, 2021 /PRNewswire/ -- The "Cell Therapy - Technologies, Markets and Companies" report from Jain PharmaBiotech has been added to ResearchAndMarkets.com's offering.

This report describes and evaluates cell therapy technologies and methods, which have already started to play an important role in the practice of medicine. Hematopoietic stem cell transplantation is replacing the old fashioned bone marrow transplants. The role of cells in drug discovery is also described. Cell therapy is bound to become a part of medical practice.

Stem cells are discussed in detail in one chapter. Some light is thrown on the current controversy of embryonic sources of stem cells and comparison with adult sources. Other sources of stem cells such as the placenta, cord blood and fat removed by liposuction are also discussed. Stem cells can also be genetically modified prior to transplantation.

Cell therapy technologies overlap with those of gene therapy, cancer vaccines, drug delivery, tissue engineering, and regenerative medicine. Pharmaceutical applications of stem cells including those in drug discovery are also described. Various types of cells used, methods of preparation and culture, encapsulation, and genetic engineering of cells are discussed. Sources of cells, both human and animal (xenotransplantation) are discussed. Methods of delivery of cell therapy range from injections to surgical implantation using special devices.

Cell therapy has applications in a large number of disorders. The most important are diseases of the nervous system and cancer which are the topics for separate chapters. Other applications include cardiac disorders (myocardial infarction and heart failure), diabetes mellitus, diseases of bones and joints, genetic disorders, and wounds of the skin and soft tissues.

Regulatory and ethical issues involving cell therapy are important and are discussed. The current political debate on the use of stem cells from embryonic sources (hESCs) is also presented. Safety is an essential consideration of any new therapy and regulations for cell therapy are those for biological preparations.

The cell-based markets was analyzed for 2020, and projected to 2030. The markets are analyzed according to therapeutic categories, technologies and geographical areas. The largest expansion will be in diseases of the central nervous system, cancer and cardiovascular disorders. Skin and soft tissue repair, as well as diabetes mellitus, will be other major markets.

The number of companies involved in cell therapy has increased remarkably during the past few years. More than 500 companies have been identified to be involved in cell therapy and 317 of these are profiled in part II of the report along with tabulation of 306 alliances. Of these companies, 171 are involved in stem cells.

Profiles of 73 academic institutions in the US involved in cell therapy are also included in part II along with their commercial collaborations. The text is supplemented with 67 Tables and 26 Figures. The bibliography contains 1,200 selected references, which are cited in the text.

Markets and Future Prospects for Cell Therapy

Key Topics Covered:

Part I: Technologies, Ethics & Regulations

Executive Summary

1. Introduction to Cell Therapy

2. Cell Therapy Technologies

3. Stem Cells

4. Clinical Applications of Cell Therapy

5. Cell Therapy for Cardiovascular Disorders

6. Cell Therapy for Cancer

7. Cell Therapy for Neurological Disorders

8. Ethical, Legal and Political Aspects of Cell therapy

9. Safety and Regulatory Aspects of Cell Therapy

Part II: Markets, Companies & Academic Institutions

10. Markets and Future Prospects for Cell Therapy

11. Companies Involved in Cell Therapy

12. Academic Institutions

13. References

For more information about this report visit https://www.researchandmarkets.com/r/lbqs59

Media Contact:

Research and Markets Laura Wood, Senior Manager [emailprotected]

For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900

U.S. Fax: 646-607-1904 Fax (outside U.S.): +353-1-481-1716

SOURCE Research and Markets

http://www.researchandmarkets.com

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Global Cell Therapy Markets Report 2021-2030: Cell Therapy Markets According to Therapeutic Areas, Technologies, & Companies - PRNewswire

Synthetic biology can benefit all of us, an expert explains – World Economic Forum

The bioeconomy covers all sectors and systems that rely on biological resources (animals, plants, microorganisms, and derived biomass, including organic waste) as well as their functions and principles. It includes and interlinks economic and industrial sectors such as food, health, chemicals, materials, energy and services that use biological resources and processes.

It is anticipated that the world will face increased competition for limited and finite natural resources given a growing population, increasing pressure on our food and health systems, and climate change and associated environmental degradation decimating our primary production systems.

Synthetic biology is an emerging field which applies engineering principles to the design and modification of living systems, thus underpinning and accelerating technological advances with clear potential to provide impact at scale to the global economy. Manufacturers are turning towards this method to efficiently produce high performance, sustainable products.

A recent McKinsey report anticipates applications from this bio revolution could have a direct global impact of up to $4 trillion per year over the next 10-20 years, enabling production of 60% physical inputs to the global economy, and addressing 45% of the worlds current disease burden. However, for synthetic biology applications to reach their full potential, its critical to ensure that access and development of knowledge in this sector, along with the relevant research tools, are distributed in low resource contexts. This can help to avoid the technology being centered solely in advanced, resource rich economies and widening inequalities in the global bioeconomy.

Dr. Jenny Molloy, Senior Research Associate at the Department of Chemical Engineering and Biotechnology, University of Cambridge, studies the role and impact of open approaches to intellectual property for a sustainable and equitable bioeconomy.

Her work focuses on better understanding problems facing researchers accessing biological research tools in low resource contexts, particularly Latin America and Africa. Her team develops innovative technologies for local, distributed manufacturing of enzymes to improve access and build capacity for biological research. The broader aim of her research is to contextualize open source approaches to biotechnology within current narratives of innovation and the bioeconomy policy agenda. She is also a member of the World Economic Forum Global Future Council on Synthetic Biology.

We discussed new developments, challenges, and her ideal scenario for the bioeconomy policy agenda for the next 10 years. Here's what she said:

Realizing that the current system of how we fund, reward, publish and disseminate science, and how we balance public and private interests in technology is quite recent and could be changed.

Originally, I worked on advocacy for open data and open science (which fortunately is now much more mainstream within research culture), and then my introduction specifically to bioeconomy policies came when I worked on genetic modification of dengue mosquitoes for my doctorate. This put me right at the intersection of global health, synthetic biology, and the bioeconomy in a field nested in a complex tangle of ethics, regulation, responsible innovation, and public opinion.

At the same time, I was contributing to projects on open science for development and getting more interested in how to make access to science, innovation, and its benefits truly global. Everything started pointing to the imperative of working to ensure that we collectively build a global bioeconomy that is equitable and economically and environmentally sustainable.

Id say the ability to de novo synthesise DNA at scale and precisely edit it. When I was trying to genetically engineer mosquitoes, constructing DNA modules was laborious and it was really a roll of the dice as to where in the genome that DNA would end up. Having more affordable ways to write as well as read DNA with increased elegance, precision editing of CRISPR has enabled exciting advances to address so many global challenges: from drug discovery to crop improvement.

That is why I find enabling tools and technologies so exciting: they underpin innovation and users will deliver applications that the original developers didnt dream about. A lot of my work focuses on how to ensure that these developments reach all scientists and not only those in high income countries.

I would say the perception and narrative that is strongly embedded in biotechnology at all levels that open source means uncommercialisable.

Unfortunately, this leads to an unwillingness to creatively explore openness as one possibility within a whole range of Intellectual Property (IP) strategies. I wish people knew to ask, What impact do I want to achieve in the world and to what extent can protecting or openly sharing this technology get me there?. Sometimes, youll land back on patenting everything because the promise of a monopoly is required to unlock sufficiently risk tolerant investment. That is OK!

However, the answer is likely more nuanced when your goal is also environmental or social impact or where you have a user community that could contribute back significant innovations or for many other reasons. Teslas patent pledge in 2014 was likely partially because their success depends on public and private investment in infrastructure like charging stations, so while sharing their technology might allow competitors to get to market faster, that could increase the number of electric cars on the road and the interests of electric car drivers and industry. All this nuance gets missed if you dont ask the question.

One of the best sources of knowledge in biotechnology is, perhaps somewhat ironically, published patents! Developing and emerging economies have immense freedom to apply this knowledge commercially as very few biotech patents have been filed in the Global South while many more have expired and entered the public domain.

However, there are major challenges to making that knowledge used and useful, including having enough people skilled in the art and providing an enabling environment - well equipped labs, reliable supply chains, responsive regulation and funding. Open source approaches play an important role here because beyond open licensing they also encourage collaborative development and sharing of know how, which is essential to overcome barriers to building capacity and innovation.

The application of precision medicine to save and improve lives relies on good-quality, easily-accessible data on everything from our DNA to lifestyle and environmental factors. The opposite to a one-size-fits-all healthcare system, it has vast, untapped potential to transform the treatment and prediction of rare diseasesand disease in general.

But there is no global governance framework for such data and no common data portal. This is a problem that contributes to the premature deaths of hundreds of millions of rare-disease patients worldwide.

The World Economic Forums Breaking Barriers to Health Data Governance initiative is focused on creating, testing and growing a framework to support effective and responsible access across borders to sensitive health data for the treatment and diagnosis of rare diseases.

The data will be shared via a federated data system: a decentralized approach that allows different institutions to access each others data without that data ever leaving the organization it originated from. This is done via an application programming interface and strikes a balance between simply pooling data (posing security concerns) and limiting access completely.

The project is a collaboration between entities in the UK (Genomics England), Australia (Australian Genomics Health Alliance), Canada (Genomics4RD), and the US (Intermountain Healthcare).

For example, basic laboratory equipment like incubators are typically no longer protected by IP but you will rarely find full assembly and repair instructions online: open hardware projects provide this and bring together communities of developers and manufacturers to enable local manufacturing. Access to enzymes is an almost ubiquitous challenge in the Global South and while many useful enzymes are now in the public domain, it can be time consuming to find the DNA and protocols to express them.

Open toolkits like the Research in Diagnostics DNA Collection designed by my lab and many collaborators and distributed through the Free Genes project at Stanford provides a ready to go solution that with the correct manufacturing practices, quality management systems and regulatory approvals could also be used for diagnostics kits. Local manufacturing of molecular diagnostics is a possibility we are exploring with collaborators in Cameroon and Ghana, for example through the AfriDx project funded by EDCTP.

A great example of an open project that has already had a direct impact on scientific progress is the Structural Genomics Consortium, a public-private-partnership which has openly released data, materials and research tools for drug discovery against medically relevant human protein structures to academia and industry for around 20 years, resulting in thousands of collaborations and scientific papers and over 1500 protein structures entering the public domain. The leaders of the consortium continue to push the model further, for example launching pharma companies that aim to apply an open approach to drug discovery for rare childhood cancers.

Realizing that the current system of how we fund, reward, publish and disseminate science and how we balance public and private interests in technology is quite recent and could be changed.

My ideal scenario is that the global bioeconomy policy agenda is truly global, so that over the next 10 years countries in the Global South, that host so much of the biodiversity that is fuelling the bioeconomy, are able to shape that agenda, to level up innovation capacities, and to benefit from the bioeconomy on their own terms.

My advice to global leaders and policymakers is to ensure that all countries get a seat at the table and focus on building out more than local or regional policies but also systems for international governance that can adapt to the extraordinary pace of technical and social change in the bioeconomy.

The Global Future Council on Synthetic Biology has focused a lot of our attention on how to embed the values of sustainability, equity, humility and solidarity into the future bioeconomy policy agenda, providing a compass rather than a map, because we think this is important to ensure that synthetic biology is being harnessed to create a world in which we want to live.

Written by

Abhinav Chugh, Acting Content and Partnerships Lead, World Economic Forum

The views expressed in this article are those of the author alone and not the World Economic Forum.

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Synthetic biology can benefit all of us, an expert explains - World Economic Forum