What is Transcranial Magnetic Stimulation (TMS)?

What is Transcranial Magnetic Stimulation (TMS)?

The basics of TMS:

TMS is a neuromodulatory technique which applies magnetic pulses to the brain via a coil. An electric current is delivered to the coil, which acts as the magnetic field generator in the procedure. The generated magnetic field inducesan electrical current in the brain. Different coil types are used to elicit different magnetic field patterns, and using more focal points can elicit a deeper magnetic field to stimulate deeper cortical layers. Stimulation is typically applied at a sufficient intensity to trigger action potentials in proximate neurons. For example, TMS over the motor cortex can result in a finger twitch. Applying several pulses of TMS in a row is called repetitive TMS or rTMS. The timing of the pulses can determine how the brain changes in response. rTMS can sometimes disrupt how a brain region is working, leading to what is called a functional lesion. This selective interference gives it credence in therapies aiming to modulate the relative excitability of a brain region. Additionally, when combined with other neuroimaging techniques, TMS can be used to map behavior related circuitry with spatial and temporal precision.1 rTMS can lead to lasting changes in brain function which is why it is used for treatment. Long-term potentiation (LTP) and long-term depression (LTD) are the implicated cellular mechanisms behind rTMS. Some areas TMS is currently being explored include: stroke rehabilitation, parkinsons, depression, migraine, pain management, and auditory hallucination.

What is the TMS device look like?

A TMS stimulator is the size of mini-fridge and has a power cable. It will have various controls on it to adjust stimulation parameters such as pulse intensity, number of pulses, and pulse frequency. The coil looks like one or more loops. For example, a figure-8 coil is two touching loops. A cable connects the coil to the stimulator. The coil is held over the head (the part to be stimulated) by the hand of the operator, or by a mechanical arm.

Credit: Harvard TMS Course

What does TMS feel like? What are the side-effects?

Repetitive TMS is a noninvasive form of brain stimulation used for depression. Unlike vagus nerve stimulation or deep brain stimulation, rTMS does not require surgery or implantation of electrodes. And, unlike electroconvulsive therapy (ECT), rTMS doesnt cause seizures or require sedation with anesthesia. According to Mayo Clinic2, rTMS is generally considered safe and well-tolerated. However, it can cause some side effects.

Common side-effects effects of TMS stimulation are related to discomfort on the scalp. This discomfort should go away after the TMS session. Rarely, someone might faint or have a seizure while undergoing stimulation. Other potential side effects include: a transient confusion related to disruptions in cognition, hearing, or vision.

Side effects are generally mild to moderate and improve shortly after an individual session and decrease over time with additional sessions. According to Mayo Clinic, side effects may include:

Your doctor can adjust the level of stimulation to reduce symptoms or may recommend that you take an over-the-counter pain medication before the procedure.

Serious side effects are rare. According to Mayo Clinic, uncommon side effects may include:

More study is needed to determine whether rTMS may have any long-term side effects.

Where can I get TMS?

In the United State rTMS has been approved by the FDA for the treatment of some kinds of depression. You can use the free tool below to find doctors and clinicswho provide TMS treatment:

Find a TMS Provider

Credit: Magstim

References:

1Siebner, H. R., Bergmann, T. O., Bestmann, S., Massimini, M., Johansen-Berg, H., Mochizuki, H., & Pascual-Leone, A. (2009). Consensus paper: combining transcranial stimulation with neuroimaging.Brain stimulation,2(2), 58-80.

2Mayo Clinic Staff. (2018, November 27). Transcranial magnetic stimulation. Retrieved February 4, 2019, from https://www.mayoclinic.org/tests-procedures/transcranial-magnetic-stimulation/about/pac-20384625

More:

What is Transcranial Magnetic Stimulation (TMS)?

Posted in Tms

Transcranial Magnetic Stimulation (TMS) at The Johns …

TMS is a non-invasive method of brain stimulation that relies on electromagnetic induction using an insulated coil placed over the scalp, focused on an area of the brain thought to play a role in mood regulation. The coil generates brief magnetic pulses, which pass easily and painlessly through the skull and into the brain. The pulses generated are of the same type and strength as those generated by magnetic resonance imaging (MRI) machines. When these pulses are administered in rapid succession, it is referred to as repetitive TMS or rTMS, which can produce longer lasting changes in brain activity.

rTMS has been shown to be a safe and well-tolerated procedure that can be an effective treatment for patients with depression who have not benefitted from antidepressant medications or cannot tolerate antidepressant medications due to side-effects.TMS was FDA-cleared in 2008 and now is widely available at clinics and hospitals across the country.

We are pleased to announce that the Johns Hopkins Brain Stimulation Program is now offering Deep Transcranial Magnetic Stimulation (dTMS) utilizing the H-coil, which is a novel rTMS tool that enables direct stimulation of deeper and larger brain volumes. This coil is designed to affect extensive neuronal pathways, including deeper cortical regions and fibers targeting subcortical regions, without a significant increase in the electric field induced in superficial cortical layers (Levkovitz et al., 2015).

In addition to dTMS, the Brain Stimulation program continues to offer conventional TMS using the figure-of-8 coil.

rTMS therapy is not appropriate for all patients. Before scheduling you for treatment, you must first be evaluated by one of our TMS psychiatrists to determine if rTMS would be safe and appropriate for you.

If you reside locally and are interested in being evaluated for outpatient rTMS treatment, or to learn more about our program, please contactMichael Tibbs.

Sample TMS consent formPatient metal screening form

Read the rest here:

Transcranial Magnetic Stimulation (TMS) at The Johns ...

Posted in Tms

Bonafont Launching Transplaces Advanced Software-as-a …

DALLAS--(BUSINESS WIRE)--Transplace, the premier provider of logistics technology and services, today announced a new contract with Bonafont, a healthy water bottle brand in the Danone global food and beverage portfolio, for its state-of-the-art Transportation Management System (TMS). Transplaces TMS will allow real-time visibility into the leading Mexican water brands entire transportation network. The TMS presents comprehensive data, such as track-and-trace of shipments throughout Mexico, transportation service metrics, and other critical business intelligence to speed decision-making, improve supply chain strategies, and address Bonafonts role in Danones unwavering commitment to sustainable business practices.

We chose to partner with Transplace because of their great success with other major corporations here in Mexico, said Pedro Urow, Mexico VP of Operations at Bonafont. We have seen impressive examples of the ways Transplace has lowered logistics costs and increased fleet utilization by maximizing vehicle capacity and eliminating empty kilometers. Transplace will automate our data entry and manual processes to save time and labor costs, while increasing efficiencies across our transportation network.

Transplace offers an award winning, multitenant TMS as a software-as-a-service (SaaS) product or as part of a managed transportation solution. The Transplace TMS offers a combination of power, scalability, integration, and affordability, allowing shippers to rapidly deploy the platform to reduce transportation costs, improve service levels, automate processes, streamline execution, and lower operational risk. The dynamic dashboards provide key performance indicators, along with a graphical 360-degree view of all shipments at all times. With Transplaces TMS, Bonafont will improve overall on-time pick-up, along with delivery and tender acceptance levels. The comprehensive, cloud-based TMS spans the core functionality of planning, execution, and settlement across all modes with strong analytics, performance management, and optimization.

We have over 700 team members in our Mexico operations who understand the nuances of each region and local market to drive successful logistics strategies, said Frank McGuigan, CEO of Transplace. As a part of Danone, we know Bonafont is committed to reducing its carbon footprint, and we look forward to supporting their sustainability efforts. Our TMS will optimize Bonafonts dedicated fleets, boost transportation network performance, and streamline supply chain management.

Connect with a Transplace expert to learn more about innovations in logistics management services in North America and Europe: transplace.com/transplace-contact.

About Transplace

Transplace is a technology and services company that hosts a proprietary logistics platform and provides engineering and execution services for global shippers. The platform and service offering deliver process automation, network optimization, and transparency driving an improved service and cost position. Transplace also provides value-added services through our strategic capacity services business (truck brokerage and intermodal) and our border management business, which includes customs brokerage and logistics services on the Mexican border. With over 1,000 customers and $11 billion of Freight Under Management (FUM) in North America alone, and a growing client base in Europe, Transplace continues to deliver the intelligent solutions that grow and differentiate the supply chains of its customers. To learn more visit http://www.transplace.com or follow us on Twitter and LinkedIn.

Follow the company on Twitter, Facebook and the Transplace Industry Blog:https://twitter.com/transplace https://www.facebook.com/transplace/ https://blog.transplace.com/

Go here to read the rest:

Bonafont Launching Transplaces Advanced Software-as-a ...

Posted in Tms

Strategy Systems Expands Integration with Trucker Tools, adds Book It Now to TMS Platform – DC Velocity

RESTON, VA and BENTONVILLE, AR JULY 9, 2020 Trucker Tools today announced that Strategy Systems has gone live with Trucker Tools Book It Now automated load-booking for carriers, adding to its portfolio of integrations with the company and enhancing the digital freight management tools and resources available to customers of its flagship StrategyLive TMS platform.

Bentonville, Arkansas-based Strategy Systems provides StrategyLive, a complete, cloud-based, integrated portfolio of software applications and services for freight brokerages firms. Its designed to streamline the full cycle of freight management processes from carrier search and load entry to tracking, billing, payroll, mapping, carrier qualification and digital carrier relationship management. For mid- to small trucking fleets the company also provides a suite of software tools for managing the everyday tasks of running a trucking company.

Trucker Tools provides the Smart Capacity suite of real-time shipment visibility, trip planning, freight-matching, digital document management and automated booking tools for freight brokers, independent owner-operators and small-fleet truckload carriers

With the launch of Book It Now, Strategy Live expands its collaboration with Trucker Tools. The company previously had integrated and embedded into its StrategyLive TMS platform, Trucker Tools Smart Capacity predictive freight-matching and carrier management module, as well as its automated truckload shipment visibility and real-time, en-route load tracking solutions.

All are integrated with the Trucker Tools Mobile Driver App, the truckload industrys most popular smartphone-based digital management resource, which in addition to Book It Now, has 17 of the most-sought after features and functions drivers want for managing their business while on the road. The app has been downloaded and installed by nearly 950,000 independent owner-operators and is actively used by some 140,000 micro-carrier fleets. Book It Now, Smart Capacity and the GPS time-stamped shipment visibility features are fully embedded within Strategy Systems TMS.

We find more and more that small fleets and independent operators, who are the backbone of the truckload market, want to cut down on phone calls and texts, and use more simplified, automated tools to manage the booking and broker engagement process, said Dave Stevens, vice president, Strategy Systems. Book it Now was designed with this goal in mind. It complements our earlier integrations and provides a faster and easier transaction process which benefits both drivers and StrategyLive customers.Strategy Systems has been a clear leader providing superior transportation management software solutions for the mid-sized broker and small-fleet market, noted Prasad Gollapalli, founder and chief executive of Trucker Tools. We are proud to yet again expand our relationship, supporting their platform with complementary applications that increase the productivity and value of their solutions, and enable even better driver engagement.

Some 90 percent of truckload market carriers are independent owner-operators and small fleets of 10 trucks or less. The multi-functional, GPS-enabled multi-party mobile app is available for both Android- and Apple-powered smartphones and is provided free of charge to independent truckers and small fleets.

For more information, visit http://www.strategysystems.com or http://www.truckertools.com

About Trucker Tools: Trucker Tools, based in Reston, Va., is the leading provider of trip planning, shipment visibility, predictive freight matching and automated booking solutions for the transportation industry. Its ground-breaking Smart Capacity platform uses accurate, real-time data and powerful algorithms to optimally match freight by predicting when and where capacity will become available, days in advance. The companys popular driver smartphone app has been downloaded by some 900,000 owner operators and small-carrier fleets to access information and services conveniently while on the road. Included in the smartphone app is Book it Now, the industrys first digital load booking app that automates and streamlines the load search and booking process for drivers and brokers, saving time and money. Trucker Tools load tracking solution is a robust feature in the app that connects drivers with carriers and freight brokers, automating the provision and collection of real-time shipment tracking and eliminating manual check calls. Visit Trucker Tools at http://www.truckertools.com or contact us directly at: sales@truckertools.com.

Media Contact: Gary Frantz, Trucker Tools, (925) 594-1434. gary@gnfcomms.com

Visit link:

Strategy Systems Expands Integration with Trucker Tools, adds Book It Now to TMS Platform - DC Velocity

Posted in Tms

Texas Motor Speedway ready to welcome fans back to the racetrack – WFAA.com

Gov. Greg Abbott's executive order allows the track to operate at 50 percent capacity this weekend when it hosts the OReilly Auto Parts 500.

Leaders at the Texas Motor Speedway are excited about the return to the racetrack. Gov. Greg Abbott's executive order allows the track to operate at 50 percent capacity this weekend when it hosts the OReilly Auto Parts 500.

Our sport just lends itself to be able to do this, whereas other sports, football and hockey and basketball, may have some problems because of the physical, body to body contact, Texas Motor Speedway president Eddie Gossage said.

We have a plan that we developed with the help of medical care professionals. We submitted it to the state, they reviewed it at the Department of Health and they like the plan, Gossage said. "They agree with this. Its a good solid plan to make sure were taking care of the fans."

The track is taking a number of precautions, including spacing out seats to ensure no one is close to anyone outside their household. Masks are required by anyone 10 years old and older. TMS has posted nearly 10,000 signs reminding fans of the importance of social distancing.

Given the size of the venue, Gossage is hopeful the weekend will be very safe.

You can fit four-and-a-half footprints of the Cowboys stadium in our infield, Gossage said. Thats how big it is.

Abbott signed off on the race, allowing for fans in a recent executive order.

"Texans are eager for sporting and entertainment events to return, and this is a great step towards that goal," Abbott wrote. "As we continue to open Texas, it is essential that we do so in a way that keeps Texans safe and limits the spread of COVID-19. Texas Motor Speedway has put a tremendous amount of work, time, and energy into ensuring that this race meets all the necessary safety and health standards, and I applaud them for this effort.

Gossage said as long as fans help them out, things will work out well.

Do your part and be personally responsible as well and this will be just fine, Gossage said. If people will follow directions it will work just fine everybody will be just great.

More on WFAA:

Read the original post:

Texas Motor Speedway ready to welcome fans back to the racetrack - WFAA.com

Posted in Tms

Global Talent Management Software (TMS) Expected to Reach Highest CAGR by 2025| COVID-19 Impact Analysis: Cornerstone Ondemand, IBM, Lumesse, Oracle,…

This detailed and well synchronized research report about the Talent Management Software (TMS) market is the most significant, up-to-date, ready-to-refer research analysis that allows readers to draw substantial market specific cues that eventually remain crucial growth influencers in the Talent Management Software (TMS) market , more specifically under the influence of COVID-19 implications that have visibly impacted normal industry process in multiple ways, leaving a trail of tangible implications.

This well-conceived, well-compiled and thoroughly documented research report on the Talent Management Software (TMS) market is dedicated to offer a detailed output to mirror the impact analysis rendered by the COVID-19 outbreak since the turn of 2020. Thus, this thorough, meticulously crafted research report is in place to aid vital market specific decisions amongst relevant stakeholders who remain key influencers in directing favorable growth trajectory in the Talent Management Software (TMS) market more specifically under the influence of COVID-19 outbreak and concomitant developments, affecting the Talent Management Software (TMS) market in a myriad tangible ways.

This study covers following key players:Cornerstone OndemandIBMLumesseOraclePeoplefluentSkillsoftSabaSAP SuccessfactorsTalentsoftHalogen

Request a sample of this report @ https://www.orbismarketreports.com/sample-request/61728?utm_source=Puja

The report is mindfully designed to influence impeccable business discretion amongst notable stakeholders in the Talent Management Software (TMS) market, comprising research analysts, suppliers, market players and participants, notable industry behemoths and the like who remain visibly influenced by the ongoing market developments especially under the influence of COVID-19 implications. The report is targeted to offer report readers with essential data favoring a seamless interpretation of the Talent Management Software (TMS) market. The report also incorporates ample understanding on numerous analytical practices such as SWOT and PESTEL analysis to source optimum profit resources in Talent Management Software (TMS) market.

Access Complete Report @ https://www.orbismarketreports.com/global-talent-management-software-tms-market-size-status-and-forecast-2019-2025?utm_source=Puja

Market segment by Type, the product can be split into Professional ServicesTraining And EducationSupport And Maintenance

Market segment by Application, split into BFSIHealthcareIT And TelecomRetailManufacturingEducationGovernmentMedia And Entertainment

The report in its subsequent sections also portrays a detailed overview of competition spectrum, profiling leading players and their mindful business decisions, influencing growth in the Talent Management Software (TMS) market.In this latest research publication on the Talent Management Software (TMS) market, a thorough overview of the current market scenario has been portrayed, in a bid to aid market participants, stakeholders, research analysts, industry veterans and the like to borrow insightful cues from this ready-to-use market research report, thus influencing a definitive business discretion.

Some Major TOC Points:1 Report Overview2 Global Growth Trends3 Market Share by Key Players4 Breakdown Data by Type and ApplicationContinued

Besides assessing details pertaining to production, distribution and sales value chain, this detailed research output on the key-word market specifically highlights crucial developments across regions and vital countries, also lending a decisive understanding of the upcoming development scenario likely to be witnessed in the Talent Management Software (TMS) market in the near future.

Therefore, to enable and influence a flawless market specific business decision, aligning with the best industry practices, this specific research report on the Talent Management Software (TMS) market also lends a systematic rundown on vital growth triggering elements comprising market opportunities and barrier analysis.

For Enquiry before buying report @ https://www.orbismarketreports.com/enquiry-before-buying/61728?utm_source=Puja

About Us : With unfailing market gauging skills, has been excelling in curating tailored business intelligence data across industry verticals. Constantly thriving to expand our skill development, our strength lies in dedicated intellectuals with dynamic problem solving intent, ever willing to mold boundaries to scale heights in market interpretation.

Contact Us : Hector CostelloSenior Manager Client Engagements4144N Central Expressway,Suite 600, Dallas,Texas 75204, U.S.A.Phone No.: USA: +1 (972)-362-8199 | IND: +91 895 659 5155

Go here to read the rest:

Global Talent Management Software (TMS) Expected to Reach Highest CAGR by 2025| COVID-19 Impact Analysis: Cornerstone Ondemand, IBM, Lumesse, Oracle,...

Posted in Tms

Idiotic political turf war puts lives at risk: Letters to the editor – Echo Pilot

Lawmakers should not question science amid pandemic.

I found myself totally dismayed upon reading "Mask mandate reignites turf war" in the Erie Times-News on July 3. The article quoted some state representatives as stating, "We live in a free society, people can make decisions for themselves" and "I feel it is up to your personal choice whether or not to abide by this mandate."

Overall, I can agree with these statements with the huge exception that this mindset is promoting many people to buck wearing masks in public, encouraging people to potentially infect all of the people around them.

The article also stated, "Five House Republicans issued a statement questioning the science behind using a mask to contain the virus." This even raises my concern as to the level of intelligence in our House of Representatives. I dont feel anyone has the right to potentially pass along COVID-19, possibly leading to the serious illness and even death of others.

Wearing masks does not prevent the wearer from getting COVID-19, but does help stop the spread to others. If it were the other way around, fine, do whatever you want, but who wouldnt even voluntarily wear a mask to protect others? Unfortunately, the self-centered and severely partisan society we live in today seems more important than showing respect and kindness to others.

They are placing peoples health and even lives at risk in fighting this idiotic political turf war. Shame on these state representatives and all of the people refusing to wear a mask in public.

Gay Marie Catania, Erie

We express our faith best

through words and deeds

I agree with Charles Adamzycks recent letter. Sharing the love of Jesus by our actions and words are the best ways to share our faith. But this is not a forum to preach.

Brennan Manning said that the greatest cause of atheism are Christians who honor him with their lips but not with their lives. That is what people find unbelievable. But in my letters that the editors of the Erie Times-News graciously allow me to share, I try to show that faith and science can coexist.

I try to influence those who are sitting on the fence, so to speak. And yes, maybe I can influence atheists because their souls matters to me. Lee Stroebel, author of "The Case for Christ" and "The Case for Faith," was an atheist who investigated the claims made by Christians.

He came to the conclusion that there is a creator and that he became a man to lead us back to our true home.

There are clues to Gods existence that support my faith, but in reality Ive experienced Gods presence, his overwhelming love, answered prayers and even miracles. I would like to encourage anyone who doubts their faith to investigate the clues of a creator and of the empty tomb.

By the way, the song "Amazing Grace" was written by John Newton, a former atheist. I dont understand why mankind prefers the created over the creator and the temporary over the eternal.

We can see whats happening in society today. Mankind is deciding what is moral without knowing the moral lawgiver (God). The world needs to turn to God for healing.

Dave Heintzel, Erie

To defeat Trumpism, we

must defeat Mike Kelly

As the HMS Trump begins its overdue and well-deserved descent to the bottom of the sea (attaching the "USS" designation to the name feels wrong, even in jest), some elected GOP officeholders are finally showing signs of donning life jackets and jumping ship.

Its not yet clear how the U.S. representative for Pennsylvanias 16th District, our Mike Kelly, is going to play this. Studying the worsening polls, he may try to recast himself as an independent sort, radiating moderation and common sense.

If he goes this route, dont be fooled. Mike Kelly is not one of those reluctant supporters of Donald Trump, duty-bound to respect his partys choice. Kelly has always been full-bore MAGA, an early and painfully visible toady. Kelly is Trump; Trump is Kelly.

I subscribe to the notion that it wont be enough to merely defeat Trumpism in November. It must be sunk with an overwhelming and historic defeat. If not, the vestiges of Trumpism always with us will remain lurking just below the surface.

The Democrats have nominated an excellent first-time candidate to run for the 16th District seat. Please vote for Kristy Gnibus on Nov. 3 and send Trump, Kelly and Trumpism back to the muddy bottom of the American psyche, where they belong.

Richard Boler, Erie

Originally posted here:

Idiotic political turf war puts lives at risk: Letters to the editor - Echo Pilot

Meet The AI Designed To Help Humans, Not Replace Them – Forbes

ASAPP founder Gustavo Sapoznik developed software that trains customer-service reps to be radically more productive, winning the young startup an $800 million valuation.

If youve ever felt your blood boil after sitting on hold for 40 minutes before reaching an agent . . . who then puts you back on hold, consider that its often even worse on the other end of the line. A customer-service representative for JetBlue, for instance, might have to flip rapidly among a dozen or more computer programs just to link your frequent-flier number to a specific itinerary.

Imagine that cognitive load, while you have someone screaming at you or complaining about some serious problem, and youre swiveling between 20 screens to see which one you need to be able to help this person, says Gustavo Sapoznik, 34, the founder and CEO of ASAPP, a New York Citybased developer of AI-powered customer-service software.

Sapoznik remembers just such a scene while shadowing a call-center agent at a very large company (he wont name names), watching the worker navigate a Frankenstack patchwork of software, entering a callers information into six different billing systems before locating it. That was an eye-opening moment.

The problem has only gotten worse during the pandemic. Call centers for banks, finance companies, airlines and service companies are being overrun. Call volumes for ASAPPs customers have spiked between 200% and 900% since the crisis began, according to Sapoznik. Making call centers work isnt the sexiest use of cutting-edge AI, but its a lucrative one.

If we can automate half of this thing away, we can get to the same place by making people twice as productive.

According to estimates from Forrester Research, global revenues for call centers are around $15 billion a year. In all, ASAPP has raised $260 million at a recent valuation of $800 million, per data from Pitchbook. Silicon Valley heavy hitters including Kleiner Perkins chairman John Doerr and former Cisco CEO John Chambers are on ASAPPs board, along with Dave Strohm of Greylock and March Capitals Jamie Montgomery. Clients include JetBlue, Sprint and satellite TV provider Dish, all of whom who sign up for multiyear contracts contributing to ASAPPs estimated $40 million in revenue, according to startup tracker Growjo.

ASAPP has drawn this investor interest by flipping AI on its head. For years engineers have perfected artificial intelligence to perform repetitive tasks better than humans. Rather than having people train AI systems to replace them, ASAPP makes AI that trains people to be radically more productive.

Pure automation capabilities are [used] out of an imperative to reflect costs, but at the expense of customer experience. Theyve been around for 20 or 30 years but they havent really solved much of the problem, Sapoznik says. ASAPPs thinking: If we can automate half of this thing away, we can get to the same place by making people twice as productive.

The company is a standout on Forbes second annual AI 50 list of up-and-coming companies to watch, rated highly for its use of artificial intelligence as a core attribute by an expert panel of judges. Its focus on using AI to keep humans in the loop is also what sets ASAPP apart, although its competing in the same call-center sandbox as fellow AI 50 listees Observe.ai of San Francisco and Cresta, which is chaired by AI legend Sebastian Thrun, the Stanford professor who greenlit Googles self-driving car program.

ASAPPs focus is natural language processing and converting speech to text using proprietary technology developed by a group led by a found- ing member of the speech team for Apples Siri. Its software then displays suggested responses or relevant resources on a call-center agents screen, minimizing the need to toggle between applications. Sapoznik and his engineers also studied the most effective human representatives, trying to replicate their expertise into ASAPP software via machine learning. That software then coaches call-center staff on effective ways to respond to customer queries and tracks down critical information. If a caller asks how to cancel a flight, for example, ASAPP software automatically pulls up helpful documents for the agent to browse. If a customer reads a 16-digit account number, its instantly transcribed and displayed on the agents screen for easy reference.

When things go right, companies using ASAPP technology see the number of calls successfully handled per hour increase from 40% to more than 150%. That can mean lower stress for call- center workers, which in turn reduces the high turnover associated with that line of work.

A licensed pilot with a fondness for classical music who studied math at the University of Chicago, Sapoznik first applied his coding skills to his familys real estate and financial business in Miami. Id been doing some work in investments where you build machine-learning product capabilities to trade the markets. The impact there is that theres a number that goes up or goes down, he says. Merely making money didnt excite him.

Sapoznik hopes that optimizing call centers is just a start for ASAPP, which he founded in 2014. Hes actively searching for similar gigantic-size business opportunities with brokenness and tons of interesting data. He thinks ASAPP can do that because its built like a research organization80% of its 300 employees are researchers or engineers.

The exciting thing about ASAPP is not so much what theyre going after now, but whether or not they can go beyond that, says Forrester analyst Kjell Carlsson. They, like so many of us, see the incredible potential of [using] natural language processing for augmented intelligence.

Summarizing ASAPPs potential, Sapoznik draws on his experience as a pilotin aviation, automation has steadily transformed the cock- pit. Its increased safety from a pretty dramatic perspective, and it hasnt gotten rid of pilots yet, he says. Its just taken away chunks of their workloads.

Get Forbes' daily top headlines straight to your inboxfor news on the world's most important entrepreneurs and superstars, expert career advice, and success secrets.

Go here to see the original:

Meet The AI Designed To Help Humans, Not Replace Them - Forbes

Carnegie Mellons robotic painter is a step toward AI that can learn art techniques by watching people – VentureBeat

Take the latest VB Survey to share how your company is implementing AI today.

Can a robot painter learn from observing a human artists brushstrokes? Thats the question Carnegie Mellon University researchers set out to answer in a study recently published on the preprint server Arxiv.org. They report that 71% of people found the approach the paper proposes successfully captured characteristics of an original artists style, including hand-brush motions, and that only 40% of that same group could discern the brushstrokes drawn by the robot.

AI art generation has been exhaustively explored. An annual international competition RobotArt tasks contestants with designing artistically inclined AI systems. Researchers at the University of Maryland and Adobe Research describe an algorithm called LPaintB that can reproduce hand-painted canvases in the style of Leonardo da Vinci, Vincent van Gogh, and Johannes Vermeer. Nvidias GauGAN enables an artist to lay out a primitive sketch thats instantly transformed into a photorealistic landscape via a generative adversarial AI system. And artists including Cynthia Hua have tapped Googles DeepDream to generate surrealist artwork.

But the Carnegie Mellon researchers sought to develop a style learner model by focusing on the techniques of brushstrokes as intrinsic elements of artistic styles. Our primary contribution is to develop a method to generate brushstrokes that mimic an artists style, they wrote. These brushstrokes can be combined with a stroke-based renderer to form a stylizing method for robotic painting processes.

The teams system comprises a robotic arm, a renderer that converts images into strokes, and a generative model to synthesize the brushstrokes based on inputs from an artist. The arm holds a brush that it dips into buckets containing paints and puts the brush to canvas, cleaning off the extra paint between strokes. The renderer uses reinforcement learning to learn to generate a set of strokes based on the canvas and a given image, while the generative model identifies the patterns of an artists brushstrokes and creates new ones accordingly.

To train the renderer and generative models, the researchers designed and 3D-printed a brush fixture equipped with reflective markers that could be tracked by a motion capture system. An artist used it to create 730 strokes of different lengths, thicknesses, and forms on paper, which were indexed in grid-like sheets and paired with motion capture data.

In an experiment, the researchers had their robot paint an image of the fictional reporter Misun Lean. They then tasked 112 respondents unaware of the images authorship 54 from Amazon Mechanical Turk and 58 students at three universities to determine whether a robot or a human painted it. According to the results, more than half of the participants couldnt distinguish the robotic painting from an abstract painting by a human.

In the next stage of their research, the team plans to improve the generative model by developing a stylizer model that directly generates brushstrokes in the style of artists. They also plan to design a pipeline to paint stylized brushstrokes using the robot and enrich the learning dataset with the new samples. We aim to investigate a potential artists input vanishing phenomena, the coauthors wrote. If we keep feeding the system with generated motions without mixing them with the original human-generated motions, there would be a point that the human-style would vanish on behalf of a new generated-style. In a cascade of surrogacies, the influence of human agents vanishes gradually, and the affordances of machines may play a more influential role. Under this condition, we are interested in investigating to what extent the human agents authorship remains in the process.

Excerpt from:

Carnegie Mellons robotic painter is a step toward AI that can learn art techniques by watching people - VentureBeat

Op-ed: Hyperwar is coming. America needs to bring AI into the fight to win with caution – CNBC

A People's Liberation Army Navy fleet including the aircraft carrier Liaoning, submarines, vessels and fighter jets takes part in a review in the South China Sea on Apr. 12, 2018.

Visual China Group | Getty Images

The United States recently sent two aircraft carrier strike groups into the South China Sea in a show of military strength. The move of multiple American warships is in reaction to China holding military exercises in international waters that are contested by Vietnam and the Philippines. The stand-off raises global tensions at a time when each superpower has developed advanced technological capabilities in terms of artificial intelligence, remote imaging, and autonomous weapons systems. It is important officials in each nation understand how emerging technologies speed up decision-making but through crisis acceleration run the risk of dangerous miscalculation.

Harkening back to Prussian general and military theorist Carl von Clausewitz's famous work"On War," military doctrine the world over has been rooted in an understanding of the ever-changing character of war, the ways in which war manifests in the real world, and the never-changing nature of war, those abstractions that differentiate war from other acts namely its violent, political, and interactive elements. Military scholars and decision makers alike have discussed and debated these definitions time and time again, with the character of war often being defined by the technologies of the day, and the nature of war being articulated as the human element of armed conflict.

With the advent of AI and other emerging technologies, though, these time-honored definitions are likely to change. At a fundamental level, battle, war, and conflict are time-competitive processes. From time immemorial, humans have sought to be faster in the ultimate competition of combat, in an absolute as well as in a relative sense. And in that regard, AI will dramatically change the speed of war. It will not only enhance the human role in conflict, but will also leverage technology as never before. For not only is technology changing, the rate of that alteration is accelerating.

This is the central issue before us for armed conflict, and the side that can create, master, and leverage an equilibrium between the nature of war and the character of war, especially within the new environment of AI, data analytics, and supercomputing, will inevitably prevail in conflict. In a geopolitical environment increasingly defined by new and emerging technologies, national defense stands as one of the most consequential areas of development for the 21st century. It is important to assess the revolutionary impacts of artificial intelligence and other emerging technologies on nearly every facet of national security and armed conflict, including the accelerated pace of warfare and the critical role of continued human control.

AI, once fully realized, has the potential to be one of the single greatest force multiplier for military and security forces in human history.

Ultimately, there are significant opportunities to deploy AI-based tools, as well as major rising threats that need to be considered and addressed. A variety of technologies can improve decision-making, speed, and scalability some to a dizzying degree. But, as with so many other AI applications, policy and operational shifts are necessary to facilitate the proper integration and innovation of these emerging technologies and make sure they strengthen, not weaken, leadership capacity, general readiness, and performance in the field.

Throughout human history, militaries have operated as the most overt political tool available to governments and society. Clausewitz himself famously wrote, "War is a continuation of politics by other means." And while modern security forces play a variety of interchangeable roles (peacekeeping, stabilization, and national defense), they invariably represent the threat of violence the "mailed fist" purpose-built to ensure a particular outcome.

With this as context, it is no surprise that the ability to assure outcomes and plan for all contingencies, violent or otherwise, takes up a significant portion of military leadership and military strategists' time and energy. Here, through anything from predictive analytics to lightning-fast target acquisition, AI, once fully realized, has the potential to be one of the single greatest force multiplier for military and security forces in human history.

Indeed, as noted in a Congressional Research Service report: "AI has the potential to impart a number of advantages in the military context, [though] it may also introduce distinct challenges. AI technology could, for example, facilitate autonomous operations, lead to faster, more informed military decision-making, and increase the speed and scale of military action. However, it may also be unpredictable or vulnerable to unique forms of manipulations."

Rather than constituting a single weapon system itself, AI is instead being built into a wide variety of weapons systems and core infrastructure. Tanks, artillery, aircraft, submarines versions of each can already detect objects and targets on their own and maneuver accordingly.

Alan Radecki | U.S. Navy | Northrop Grumman | Getty Images

The interim report of the U.S. National Security Commission on Artificial Intelligence warns that:

"How the United States adopts AI will have profound ramifications for our immediate security, economic well-being, and position in the world. Developments in AI cannot be separated from the emerging strategic competition with China and developments in the broader geopolitical landscape. We are concerned that America's role as the world's leading innovator is threatened. We are concerned that strategic competitors and non-state actors will employ AI to threaten Americans, our allies, and our values. We know strategic competitors are investing in research and application. It is only reasonable to conclude that AI-enabled capabilities could be used to threaten our critical infrastructure, amplify disinformation, and wage war."

AI's role in the military and on the battlefield is thus one of catalytic power, both for good and ill. Yet, the strength of AI does not manifest in the way a bomb or new weapons platform might perform or act. Its utility is much broader. As noted by Brookings Institution scholar Chris Meserole, AI is being deployed in myriad ways by the American military: "Rather than constituting a single weapon system itself, AI is instead being built into a wide variety of weapons systems and core infrastructure. Tanks, artillery, aircraft, submarinesversions of each can already detect objects and targets on their own and maneuver accordingly."

This dynamic becomes particularly clear within the context of the spectrum of conflict modern militaries deal with today, notably hybrid conflict. Looking ahead, it will also define warfare of the future, namely through what John Allen and Amir Husain have coined as "hyperwar." The distinctions between hybrid warfare and hyperwar are important. As noted in a recent NATO report: "Hybrid threats combine military and non-military as well as covert and overt means, including disinformation, cyber attacks, economic pressure, deployment of irregular armed groups and use of regular forces. Hybrid methods are used to blur the lines between war and peace, and attempt to sow doubt in the minds of target populations."

Russian servicemen operate an S-400 Triumf anti-aircraft missile system on combat duty in the Kaliningrad Region in 2019. The system is designed to repel any contemporary aerospace attack, such as stealth and fighter aircraft, bombers, cruise and ballistic missiles, drones and hypersonic targets.

Vitaly Nevar | TASS | Getty Images

In this environment, AI can super-charge an adversary's ability to sow chaos in the battlespace and incorporate deception and surprise into their tactics in new and novel ways. By contrast, hyperwar may be defined as a type of conflict where human decision-making is almost entirely absent from the observe-orient-decide-act (OODA) loop, a popular framework developed by U.S. Air Force Colonel John Boyd for training individuals to make time-sensitive decisions as quickly as possible, especially when there is limited time to gather information. As a consequence, the time associated with an OODA cycle will be reduced to near-instantaneous responses.

The implications of these developments are many and game changing, ranging across the spectrum from advanced technological modernization to how leaders in the era of hyperwar are recruited, educated and trained. The topics of speed, efficiency, and accuracy as well as the necessity for human control of AI-powered military capabilities represent the heart of the issue in the current AI-national security debate.

With U.S. and Chinese forces maneuvering in the relatively tight operational environment of the South China Sea, reaction times are already short. As more sophisticated AI eventually enables faster and more comprehensive intelligence collection and analysis, rapid decision support, and even wide area target acquisition, we could see a premium being placed on "going first" and not risk being caught flat-footed. While AI has the capacity to magnify military capabilities and accelerate the speed of conflict, it can also be inherently destabilizing.

Now is the time for the U.S. and China to have the hard conversations about norms of behavior in an AI enabled, hyperwar environment. With both sides moving rapidly to field arsenals of hypersonic weapons, action and reaction times will become shorter and shorter and the growing imbalance of the character and nature of war will create strong incentives, in moments of intense crisis, for conflict not peace. This is foreseeable now, and demands the engagement of both powers to understand, seek, and preserve the equilibrium that can prevent the sort of miscalculation and high-speed escalation to the catastrophe that none of us wants.

ByJohn R. Allen, a retired four-star military general and Brookings Institution president, and Darrell West, vice president of governance studies at Brookings. This article is excerpted from their forthcomingTurning Point: Policymaking in the Era of Artificial Intelligence.

Link:

Op-ed: Hyperwar is coming. America needs to bring AI into the fight to win with caution - CNBC

World’s First AI Therapist, SARAH, is Born. – PRNewswire

NEW YORK, July 14, 2020 /PRNewswire/ -- In times of uncertainty, fear, anxiety, and stress are natural responses to real or perceived threats. Faced with the new realties, of today's current environment, an idea was born. SARAH the AI Therapist, where users can engage 24/7 to seek comfort, advice and inspire confidence by positively influencing their lives, particularly when suffering from psychological and mental health issues. Unlike chat bots, SARAH'sartificial intelligence allows it to become personal with its users, improving its responsiveness as time progresses. Unique features include the ability to recall previous conversations, detect emotions by sound vibration and calm users down by providing solutions. By listening and understanding SARAH can provide counseling therapy and optimize users' schedules through a reminder and track feature.

SARAH can help individuals, couples, and families within multiple fields of Therapy, from depression to PTSD and from couples counseling to children's psychology. Moreover, SARAH can advise its users on the ways they can improve their relationship with themselves as well as pointers on how they can finally rid themselves of their negative habits and replace them with positive ones.

Mental health is a serious issue and with ever-increasing pressure on our daily lives symptoms and signs ofdepression, anxiety, and fear are not going away. Since the beginning of the COVID-19 pandemic and isolation efforts in March, people everywhere have been reporting increasing pressure on their mental health. Whether it is because they are now out of employment or fear losing their job, people are struggling to piece together money to pay bills. The continuous onslaught of worry and insecurity is leading to greater psychological issues than ever before.

There is so much SARAH can contribute and Founder, Alireza Dehghanis very excited about this. "This is an opportunity for all of us to make a difference by joining a cause and contributing back to society."

SARAH has started a crowdfundingcampaign on Indiegogoand funds will be used to advance Dehghan's dream of providing affordable on-demand therapy to all those in need."In an ideal world, everyone should have easy, affordable access to mental health care professionals and be able to properly treat their maladies" states Dehghan.

Subscriptions are available at a 65% discount whereby sponsors can help by donating a subscription to a mentally ill person or families struggling with the repercussions of COVID-19.

Media Contact

Alireza DehghanPhone Number: +1 (917)-936-2030Email: [emailprotected]

Related Images

sarah.png SARAH The world's first AI therapist

Related Links

Indiegogo campaign

Instagram

SOURCE SARAH AI

Originally posted here:

World's First AI Therapist, SARAH, is Born. - PRNewswire

Lunit Expands Collaboration with GE Healthcare to Advance AI Adoption – Imaging Technology News

July 14, 2020Lunit, a leading medical AI startup, announced the expansion of its collaboration with GE Healthcare. This collaboration between GE Healthcare and Lunit will help make AI algorithms more accessible to clinicians, alleviate clinical strain and streamline workflows supporting better patient outcomes.

GE Healthcare recently introduced itsThoracic Care Suitefeaturing a collection of eight artificial intelligence (AI) algorithms fromLunit INSIGHT CXR.The AI Suite quickly analyzes chest x-ray findings and flags abnormalities to radiologists for review, including pneumonia, which may be indicative of COVID-19 as well as tuberculosis, lung nodulesand other radiological findings.

This collaboration between GE Healthcare and Lunit is one of the first of its kind to bring commercially available AI products from a medical AI startup to an existing X-ray equipment manufacturer making Lunit INSIGHT CXR available via Thoracic Care Suite to GE Healthcares thousands of global fixed, mobile, and R&F X-ray customers at point of sale.

As a startup company, our vision is to have AI to be recognized as the new standard of care, said Brandon Suh, CEO of Lunit. We have been applying our AI into various types of medical images. Among them, Lunit INSIGHT CXR is one of our major products that has been commercialized since a few years ago. To have our AI made available with a market-leading vendor like GE Healthcare especially as part of the Thoracic Care Suite is a significant advancement in delivering solutions to various customers within GE Healthcares install base and bringing us all one step closer to embracing AI as a part of todays standard of care. We will continue to push forward and cooperate with market leaders through extended partnerships and collaborations, increasing the number of global use cases of our AI.

Lunits original algorithm, Lunit INSIGHT CXR, is designed to provide accurate and instant analysis of chest x-ray images by mapping the location of the findings and displaying the scored calculation of its actual existence. In a COVID-19 setting, Lunit INSIGHT CXR can be useful in quickly identifying high-risk cases as well as monitoring patients progression and regression of mild respiratory symptoms. The algorithm performs at 97-99% accuracy rate (Area Under the Curve - AUC), and according to studies published in Radiologyand JAMA Network Open, a physician can see their performance increase up to 20% upon interpreting with the assistance of Lunits AI.

Like Lunit, GE Healthcare is committed to developing and providing AI solutions to help alleviate our customers most pressing challenges, says Katelyn Nye, General Manager of GE Healthcare mobile X-ray and AI products. Weve watched Lunits success closely over the past several years and are excited to marry our expertise as a well-established x-ray manufacturer with the nimbleness of a startup like Lunit. We believe that by featuring Lunit INSIGHT CXR as a part of our Thoracic Care Suite we can meet our customers most pressing needs and expand AI adoption in healthcare.

Lunit is also actively working with GE Healthcare to integrate its AI solutions into GEsEdison Open AI Orchestrator, an algorithm management solution to help physicians and healthcare organizations work more efficiently and effectively. Available via a standalone server or integrated into GE Healthcares Centricity Picture Archiving and Communication System (PACS) and Enterprise Imaging System (EIS), these algorithms can help clinicians manage chest radiography reading more efficiently, improve clinicians workflow and provide a more native reading experience. Once complete, this offering will help reduce the complexity of implementing and managing multiple systems and algorithms as well as provide an easy way for organizations to adopt and explore AI.

Additionally, Lunit is an innovator under GE Healthcares Edison Developer Program, which helps healthcare providers gain easier access to market-ready algorithms and applications such as Lunit INSIGHT CXR by directly integrating these technologies into existing workflows. As such, Lunit and GE Healthcare are actively working to deliver novel and targeted deep-learning technology for healthcare systems via Edison, GE Healthcares secure intelligence platform.

For more information: http://www.lunit.io

More:

Lunit Expands Collaboration with GE Healthcare to Advance AI Adoption - Imaging Technology News

Adobe tests an AI recommendation tool for headlines and images – TechCrunch

Team members at Adobe have built a new way to use artificial intelligence to automatically personalize a blog for different visitors.

This tool was built as part of the Adobe Sneaks program, where employees can create demos to show off new ideas, which are then showcased (virtually, this year) at the Adobe Summit. While the Sneaks start out as demos, Adobe Experience Cloud Senior Director Steve Hammond told me that 60% of Sneaks make it into a live product.

Hyman Chung, a senior product manager for Adobe Experience Cloud, said that this Sneak was designed for content creators and content marketers who are probably seeing more traffic during the coronavirus pandemic (Adobe says that in April, its own blog saw a 30% month-over-month increase), and who may be looking for ways to increase reader engagement while doing less work.

So in the demo, the Experience Cloud can go beyond simple A/B testing and personalization, leveraging the companys AI technology Adobe Sensei to suggest different headlines, images (which can come from a publishers media library or Adobe Stock) and preview blurbs for different audiences.

Image Credits: Adobe

For example, Chung showed me a mocked-up blog for a tourism company, where a single post about traveling to Australia could be presented differently to thrill-seekers, frugal travelers, partygoers and others. Human writers and editors can still edit the previews for each audience segment, and they can also consult a Snippet Quality Score to see the details behind Senseis recommendation.

Hammond said the demo illustrates Adobes general approach to AI, which is more about applying automation to specific use cases rather than trying to build a broad platform. He also noted that the AI isnt changing the content itself just the way the content is promoted on the main site.

This is leveraging the creativity youve got and matching it with content, he said. You can streamline and adapt the content to different audiences without changing the content itself.

From a privacy perspective, Hammond noted that these audience personas are usually based on information that visitors have opted to share with a brand or website.

Read more:

Adobe tests an AI recommendation tool for headlines and images - TechCrunch

Discover the Power of VUNO’s AI Solutions at ECR 2020 – WFMZ Allentown

SEOUL, South Korea, July 14, 2020 /PRNewswire/ -- VUNO Inc., South Korean artificial intelligence (AI) developerannounced that it will attend the European Congress of Radiology 2020 (ECR 2020)to be held fromJuly 15 to July 19, 2020 to showcase the power of its flagship AI radiology solutions that have recently received the CE mark.As part of its ambitious plan to go global, VUNO is set to seize this opportunity to further expand its networks with sales prospects and business partners from all around the world.

ECR, one of the leading events in the field of radiology, will be joined by industry experts, medical & healthcare professionals, modality manufacturers and solutions developers, etc. In the light of the COVID 19 epidemic, the congress organizers have decided to opt for an online-only event. With about 2,100 leading industry representatives onboard, the exhibition of ECR 2020 can be accessed from 08:00 a.m. July 15 to 21, until 11:55 p.m. CEST. Free registration & participation is available on the ECR 2020 Virtual Exhibition website. (https://ecr2020.expo-ip.com/).

VUNO's exhibition at the event will include VUNO MedLungCT AI that detects, locates, and quantifies pulmonary lung nodules on CT images, VUNO Med-Chest X-Ray that assists in the chest X-ray readings of common thoracic abnormalities on chest radiographs. VUNO Med-DeepBrain is a diagnostic supporting tool for degenerative brain diseases through brain parcellation & quantification on brain MR images.

On top of the three solutions to be showcased at this event, VUNO has two other solutions that have gained CE certifications recently- VUNO Med-BoneAge and VUNO Med Fundus AI. All these five products are now available to be marketed in countries where CE marking is acceptable.

VUNO Med solutions are designed to be agnostic to any devices and any environments offering seamless integration with any PACS and/or EMR systems. They are offered via cloud servers allowing users to analyze images anytime, anywhere with access to the Internet. They are also available through on-premise installations as well.

VUNO has the highest number of clients with more than120 medical institutions in Korea alone. With its huge successes under its belt rooted in the proven effectiveness and safety through clinical trials and practices, the company is embarking on a new endeavor to proclaim its technical prowess in overseas markets now by signing partnerships with global healthcare giants like M3, a SONY subsidiary and Japan's largest data platform company.

For more detailed information on VUNO, visit https://www.vuno.co/.

Read the original:

Discover the Power of VUNO's AI Solutions at ECR 2020 - WFMZ Allentown

AI.Reverie wins contract to improve navigation capabilities for USAF – Airforce Technology

]]> AI.Reverie has secured SBIR Phase 2 contract from AFWERX. Credit: Markus Spiske on Unsplash.

Sign up here for GlobalData's free bi-weekly Covid-19 report on the latest information your industry needs to know.

AI.Reverie has secured Phase 2 Small Business Innovation Research (SBIR) contract from AFWERX for the US Air Force (USAF).

Under the $1.5m contract, AI.Reverie will build artificial intelligence (AI) algorithms and improve navigation capabilities supporting the 7th Bomb Wing at Dyess Air Force Base (AFB).

The company will use synthetic data to train and improve the accuracy of vision algorithms for navigation through its Rapid Capabilities office.

Synthetic data or computer-generated images are economical and can be generated faster than hand-labelled photos, solving the limitations associated with real data.

The advanced technology creates vision algorithms needed to save lives during operations.

Phase 2 SBIR contract awarded to AI.Reverie follows its co-publication with the IQT Lab CosmiQ Works that highlighted the value of synthetic data to train computer vision algorithms.

Furthermore, the research partners released RarePlanes for academic and commercial use with open dataset of real and synthetic overhead imagery.

USAF Major Anthony Bunker said: As the world has gotten smaller, the ability to navigate based on visual terrain features has become an ever-increasing challenge.

Computer vision algorithms can be trained to recognise these world-wide terrain features by ingesting large amounts of diverse data.

We are excited to collaborate with AI.Reverie to improve navigation capabilities given the companys ability to generate fully annotated data at scale with its synthetic data platform.

In May this year, AI.Reverie and Green Revolution Cooling (GRC) secured AFWERX SBIR Phase I contract from the USAF. The contract was for enhancing computer vision models for the US Department of Defense (DoD).

See the article here:

AI.Reverie wins contract to improve navigation capabilities for USAF - Airforce Technology

The journey that organizations should embark on to realize the true potential of AI – The Indian Express

New Delhi | Updated: July 13, 2020 4:33:10 pm

Implementing Artificial Intelligence (AI) in an organization is a complex undertaking as it involves bringing together multiple stakeholders and different capabilities. Many companies make the mistake of treating AI as a pure play technology implementation project and hence end up encountering many challenges and complexities peculiar to AI. There are three big reasons for increased complexity in an AI program implementation (1) AI is a portfolio based technology (example, comprising sub-categories such as Natural Language Processing (NLP), Natural Language Generation (NLG), Machine Learning) as compared to many standalone technology solutions (2) These sub-category technologies (example, NLP) in turn have many different products and tool vendors with their own unique strengths and maturity cycles (3) These sub-category technologies (example, NLG) are specialists in their functionality and can solve certain specific problems only (example, NLG technology helps create written texts similar to how a human would create it). Hence, organizations need to do three important things Define Ambitious and Achievable Success Criteria, Develop the Right Operating Rhythm, and Create and Celebrate Success Stories to realize the true potential of AI.

Most companies have very narrow or ambiguous success criteria definition of their AI program. These success criteria are not defined holistically and hence may end up providing sub-optimal benefits to the organization. We suggest that the success criteria of an AI program need to not only be ambitious, achievable, and actionable but also tightly integrated with the overall key strategic objectives and priorities of the organization. For example, a bank which is trying to reduce the number of customer complaints and improve the customer experience as key strategic goals can benefit immensely from integrating AI program goals with the goals of this important program (example, leverage machine learning and analytics to analyze past complaints data and better understand customer complaints patterns and journeys and decision points). This interlocking of success criteria will help AI program leaders with the right yardsticks to align and measure their progress and contribution. Additionally, it also helps them get the right visibility and sponsorship at the senior leadership levels in the organization that further improves the chances of success of the AI program.

Also Read: Can Humans and AI coexist to create a hyper-productive HumBot organisation?

A successful AI program requires four key ingredients Right Data, Diverse Skills, Scalable Infrastructure and Seamless Stakeholder Alignment. It is said that Data is the food of an AI program and hence having the right data (example, the volume of data, type of data, and quality of data) at the right time is critical to ensure AI programs have the required fuel and energy to complete their intended journey. While good AI skills are in short supply, leveraging constructs such as having a Nimble CoE (Centers of Expertise) increases chances of optimal utilization of these rare and expensive skills across the organization. Finally, getting various important stakeholders (example, Global Process Owners, IT Leaders, Internal Control & Risks, Continuous Improvement, and HR) seamlessly work together is important to reduce friction and increase AI program velocity.

Also Read:With the power of AI, India can reimagine delivery of public services

It is said that success breeds more success. While AI programs typically focus a lot on efficiency and productivity improvements, many AI programs also generate significant non-direct-quantifiable benefits (for example, improvement in stakeholder experience, improvement in employee engagement and morale). A recent Deloitte survey indicates that 44 per cent organizations felt AI has increased the quality of their products/services while 35 per cent organizations found that AI has enabled them to make better decisions in their organizations. Successful companies find a way to identify these simple, holistic stories and narrate them compellingly and consistently in multiple forums at all levels in their organizations. Humans, by design, are inspired better by stories (than by just numbers) and hence creating a powerful story that combines the quantifiable (example, number of hours saved) with other benefits (example, better decision making ability) can galvanize the entire organization and facilitate rapid and increased adoption of AI at all levels and in all units of the organization.

The revered Chinese saint, Lao Tzu, once famously remarked that A journey of thousand miles begins with a single step. The AI journey in an organization is no exception. While AI implementations are typically more complex and nuanced, companies can leverage the 3-pronged approach mentioned above to realize the true and full potential of AI. While a successful AI program implementation can bestow significant financial benefits on an organization, it also activates the divine journey of freeing up humans to do what they do best leverage their sophisticated brains to introspect, explore, learn, love, empathize and solve the most intricate and defining problems of our generations.

The authors are Ravi Mehta, Partner; Sushant Kumaraswamy, Director; Sudhi. H, Associate Director; and Prashant Kumar, Senior Consultant, Deloitte India.

The Indian Express is now on Telegram. Click here to join our channel (@indianexpress) and stay updated with the latest headlines

For all the latest Technology News, download Indian Express App.

IE Online Media Services Pvt Ltd

Continue reading here:

The journey that organizations should embark on to realize the true potential of AI - The Indian Express

Global Plaque Psoriasis Treatment Market to Witness Rapid Development During the Period 2017 2025 – Jewish Life News

Plaque psoriasis is a chronic, autoimmune inflammatory disorder which leads to overproduction of skin cells. The skin is characterized by inflamed, raised, scaly, red plaques and lesion. The intensity and frequency of psoriasis are affected by environmental factors such as sun exposure, smoking, HIV infection, and alcoholism. Metabolic syndrome and cardiovascular disease are common in psoriasis patients. Psoriasis increases the chances of myocardial infarction in younger psoriasis patients by three folds.

Moreover, severe psoriasis leads to 3.5 years reduced life expectancy in males relative to individuals without psoriasis. Psoriasis arthritis is a distinct syndrome which occurs in one-third of psoriasis patient with the onset of rheumatic arthritis.

Psoriasis plaque are distinguished by three features, an infiltrate featuring T-cells, the extravagant growth of poorly differentiated keratinocytes and the presence of dilated dermal blood vessels. Most of the introduced therapies for psoriatic were developed as to target T-cells or their inflammatory mediators including cytokines, receptors, and ligands.

Plaque Psoriasis Treatment Market: Dynamics

The demand for plaque psoriasis treatment market is expected to boom with the increasing number of pipeline psoriasis molecule and the number of biologics being launched. Janssen Biotec is seeking for the market approval of Guselkumab. The molecule is in the Phase III trial as a subcutaneous administered therapy for the treatment of plaque psoriasis.

Moreover, Gelantin Therapeutics Inc. announced positive data from its phase 2 study of its drug GR-MD-02 to treat moderate-to-severe plaque psoriasis. The company is now seeking for strategic partnership for its drug development program.

The advent of biologics has also shifted the preference from systemic therapy to meet the existing need. The systemic therapy suppresses the entire immune system as the clinician needs to do routine laboratory monitoring because of myelosuppression, hematologic side effects and increased renal and liver toxicity. Moreover, the systemic therapy is also contraindicated in nursing mothers, pregnant women, and individuals with kidney and liver diseases.

Around 125 million people worldwide have psoriasis out of which 80%, have plaque psoriasis. The need for safe plaque psoriasis therapy in children is essential as about one-third of the psoriasis cases are in children. Etanercept was approved by the DA as an extended indicated for children of age 4 and above.

To remain ahead of your competitors, request for a sample [emailprotected]

https://www.persistencemarketresearch.com/samples/16069

Plaque Psoriasis TreatmentMarket: Segmentation

On the basis therapy the plaque psoriasis treatment market can be segment as:

Phototherapy and systemic therapy should only be used in cases where a topical treatment is inadequate. Novel systemic treatments are now being introduced where a range of biologics are sed. The mode of treatment follows a psoriasis treatment ladder. Initially, topical treatment is given, if the skin fails to respond then phototherapy is given. The third step involves the use of systemic treatment which may be through the administration of pills or injection.

On the basis drug class the plaque psoriasis treatment market can be segment as:

To receive extensive list of important regions, Request Methodology here @

https://www.persistencemarketresearch.com/methodology/16069

TNF- inhibitor was the first class of biologics which were successful in delivering the treatment while still maintaining the safety profile. Enbrel was the first molecule to be approved followed by Remicade and Humira. The introduction of these molecules increased the overall sales of the psoriasis drugs and also increased the physicians comfort and familiarity.

Plaque Psoriasis TreatmentMarket: Region-wise Outlook

North America region dominates the plaque psoriasis market owing to the increasing approval of pipeline drugs and supplemental biologics. In November 2016, the FDA approved supplemental biologics license for the use of Etanercept for children aged four and older having moderate-to-severe plaque psoriasis. The approval is the first of its kind indicated for the treatment of adults with moderate-to-severe plaque psoriasis. Amgen had performed a year-long phase 3 study and 5-year open-label extension testing for the approval.

AsiaPacific is expected to be the fastest-growing region owing to the huge population base and changing lifestyle habits such as smoking. Moreover, the global market players are also exploring the developing market. Novartis launched its Cosentyx in Japan for the treatment of psoriasis arthritis in adults who are not adequately responding to systemic therapy.

You Can Request for TOC Here @

https://www.persistencemarketresearch.com/toc/16069

Plaque Psoriasis TreatmentMarket: Market Players

Company manufacturer is converting innovative research into a new therapy by constantly investing in research activities. The number of drugs approved for plaque psoriasis is constantly increasing the number of treatment options for the physician and patients. Eli Lillys interleukin inhibitor was approved by the FDA, second molecule to be approved after Novartis Cosentyx.

Some of the plaque psoriasis treatment market contributors are Allergan, Johnson and Johnson, Amgen, Abbvie, Eli Lilly, Dermira Inc., Novartis, Galectin Therapeutics, Cellceutix Corporation and Biogen Inc., Bayer.

Read more:

Global Plaque Psoriasis Treatment Market to Witness Rapid Development During the Period 2017 2025 - Jewish Life News

Sorting Out the Many Mimickers of Psoriasis – Medscape

Of the many psoriasis mimicker clinicians are likely to encounter, atopic dermatitis is likely the most common one, especially the nummular eczema variant form.

"It has an earlier age of onset, usually in infancy, and can occur with the atopic triad that presents with asthma and seasonal allergies as well,"Israel David "Izzy" Andrews, MD, said at the virtual Pediatric Dermatology 2020: Best Practices and Innovations Conference. "There is typically a very strong family history, as this is an autosomal dominant condition, and it's far more common than psoriasis. The annual incidence is estimated to be 10%-15% of pediatric patients. It has classic areas of involvement depending on the age of the patient, and lesions are intensely pruritic at all times. There is induration and crust, but it's important to distinguish crust from scale. Whereas crust is dried exudate, and scale is usually secondary to a hyperproliferation of the skin. Initially, treatments (especially topical) are similar and may also delay the formalized diagnosis of either of the two."

Another psoriasis mimicker, pityriasis rosea, is thought to be secondary to human herpesvirus 6 or 7 infection, said Dr. Andrews, of the department of dermatology at Phoenix Children's Hospital. It typically appears in the teens and tweens and usually presents as a large herald patch or plaque on the trunk. As the herald patch resolves, smaller lesions will develop on the trunk following skin folds. "It's rarely symptomatic and it's very short-lived, and clears within 6-12 weeks," Dr. Andrews noted. "It can present with an inverse pattern involving the face, neck, and groin, but sparing the trunk. This variant, termed inverse pityriasis rosea, can be confused with inverse psoriasis, which has a similar distribution. However, the inverse pattern of pityriasis rosea will still resolve in a similar time frame to its more classic variant."

Pityriasis lichenoides can also be mistaken for psoriasis. The acute form can present with erythematous, scaly papules and plaques, but lesions are often found in different phases of resolution or healing. "This benign lymphoproliferative skin disorder can be very difficult to distinguish from psoriasis and may require a biopsy to rule in or out," Dr. Andrews said. "It can last months to years and there are few treatments that are effective. It is typically nonresponsive to topical steroids and other treatments that would be more effective for psoriasis, helping to distinguish the two. It is thought to exist in the spectrum with other lymphoproliferative diseases including cutaneous T-cell lymphoma [CTCL]. However, there are only a few cases in the literature that support a transformation from pityriasis lichenoides to CTCL."

Seborrheic dermatitis is more common than atopic dermatitis and psoriasis, but it can be mistaken for psoriasis. It is caused by an inflammatory response secondary to overgrowth of Malassezia yeast and has a bimodal age distribution. "Seborrheic dermatitis affects babies, teens, and tweens, and can persist into adulthood," he said. "Infants with cradle cap usually resolve with moisturization, gentle brushing, and occasional antifungal shampoos." Petaloid seborrheic dermatitis can predominately involve the face with psoriatic-appearing induration, plaques, and varying degrees of scales. "In skin of color, this can be confused with discoid lupus, sarcoidosis, and psoriasis, occasionally requiring a biopsy to distinguish," said Dr. Andrews, who is also an assistant professor of pediatrics at the Mayo Clinic College of Medicine and Science in Scottsdale, Ariz.

Another psoriasis mimicker, pityriasis amiantacea, is thought to be a more severe form of seborrheic dermatitis. It presents with concretions of scale around hair follicles that are highly adherent and are sometimes called sebopsoriasis. "It may be associated with cutaneous findings of psoriasis elsewhere, but may also be found with secondarily infected atopic dermatitis and tinea capitis; however, in my clinical experience, it is most often found in isolation," he said. "There may be a seasonal association with exacerbation in warm temperatures, and treatment often consists of humectants like salicylic acid for loosening scale, topical steroids for inflammation, and gentle combing out of scale."

Infections can also mimic psoriasis. For example, tinea infections are often misdiagnosed as eczema or psoriasis and treated with topical steroids. "This can lead to tinea incognito, making it harder to diagnose either condition without attention to detail," Dr. Andrews said. "On the body, look for expanding lesions with more raised peripheral edges, and central flattening, giving a classic annular appearance. It's also important to inquire about family history and contacts including pets, contact sports/mat sports (think yoga, gymnastics, martial arts), or other contacts with similar rashes." Work-up typically includes a fungal culture and starting empiric oral antifungal medications. "It is important to be able to distinguish scalp psoriasis from tinea capitis to prevent the more inflammatory form of tinea capitis, kerion (a deeper more symptomatic, painful and purulent dermatitis), which can lead to permanent scarring alopecia," he said.

Bacterial infections can also mimic psoriasis, specifically nonbullous impetigo and ecthyma, the more ulcerative form of impetigo. The most frequent associations are group AStreptococcus, methicillin-susceptibleStaphylococcus aureusand methicillin-resistantS. aureus.

Dr. Andrews closed his presentation by noting that tumor necrosis factoralpha inhibitorinduced psoriasiform drug eruptions can occur in psoriasis-naive patients or unmask a predilection for psoriasis in patients with Crohn's disease, juvenile idiopathic arthritis, or other autoinflammatory or autoimmune conditions. "They may improve with continued treatment and resolve with switching treatments," he said. "Early biopsy in psoriasiform drug eruptions can appear like atopic dermatitis on pathology. When suspecting psoriasis in a pediatric patient, it is important to consider the history and physical exam as well as family history and associated comorbidities. While a biopsy may aide in the work-up, diagnosis can be made clinically."

Dr. Andrews reported having no financial disclosures.

This article originally appeared onMDedge.com.

See the rest here:

Sorting Out the Many Mimickers of Psoriasis - Medscape

India clears a psoriasis drug for COVID-19, and a tiny US biotech’s shares soar – BioPharma Dive

Dive Brief:

The battle against the new coronavirus is being waged on multiple fronts, from vaccines to prevent infection to other drugs meant to treat and manage COVID-19's many complications.

One of those complications is an overactive immune response, seemingly similar to cytokine release syndrome or CRS, which can cause potentially deadly damage to the lungs or other organs.

Researchers and scientists have been testing other anti-inflammatory drugs against that damaging immune response,but thus far have yet to succeed. The Sanofi and Regeneron arthritis drug Kevzara has failed to deliver a clear benefit in clinical trials, while a similar drug from Roche came up short in a small Italian study after flashing promise earlier.

A larger, more rigorous Actemra trial is still underway, as are tests of the cancer therapies Jakafi and Calquence.

The only drug that has conclusively been shown to reduce death in a large trial of hospitalized COVID-19 patients is the steroid dexamethasone.

But that study, called RECOVERY, didn't look at whether patients where suffering from immune responses characteristic of CRS.Indeed, the mass repurposing of drugs to target COVID-19 related CRS has alarmed some experts, fearful of causing more harm than good.

A JAMAeditorial published in late June highlighted that what is being defined as "cytokine storm" isn't fully understood, and treating those patients with drugs that indiscriminately suppress the immune system "raises concerns about impaired clearance of SARS-CoV-2 and increased risk for secondary infections."

Yet Indian drugmaker Biocon, the developer of plaque psoriasis drug called itolizumab, has claimed success in a study of 30 patients hospitalized with COVID-19 who have CRS and moderate to severe acute respiratory distress syndrome. Bioconreported that in a controlled trial, all 20 people who got itolizumab and standard treatment recovered. Three of the 10 on standard treatment alone died. Decreases in various key markers of inflammation as well as measures of oxygen levels were seen in itolizumab patients as well, according to the company.

Biocon has not provided specifics yet, however, making its claims impossible to fully assess. Still, the results were encouraging enough for the Indian government to clear use of itolizumab in very sick COVID-19 patients. That, along with additional data being generated in Cuba, where the drug was discovered, "could pave the way for discussions with regulators and other government agencies to pursue clinical development and funding in the U.S.," wrote SVB Leerink analyst Thomas Smith.

Results from an open-label, uncontrolled 24-patient study in Cuba currently under a peer review at the journal Immunity & Ageing found that itolizumab appeared to significantly reduce levels of the inflammatory protein IL-6 in the blood. The Cuban government in May also credited the use of itolizumab for an apparent reduction in deaths from COVID-19 among its citizens, though those results didn't come from a randomized, controlled trial.

Unlike Actemra and Kevzara, which inhibit an inflammatory protein called IL-6, Itolizumab blocks CD6, a protein found on the surface of many immune cells, among them effector T cells that drive inflammation in a variety of diseases. The drug was approved in India in 2013 to treat chronic plaque psoriasis under the brand name Alzumab. Equillium has since licensed rights in the U.S., Canada, New Zealand and Australia and has been aiming to develop it for a number of inflammatory conditions like asthma and lupus.

In light of the news from India, Equillium said it plans to ask the Food and Drug Administration to start a global randomized trial of itolizumab. Equillium shares more than doubled, to over $8 apiece, though that's still less than the $14 per share price at which the company went public in 2018.

Equillium had to stall testing of itolizumab which it calls EQ001 due to the pandemic. But it said Monday that those trials have now resumed.

Excerpt from:

India clears a psoriasis drug for COVID-19, and a tiny US biotech's shares soar - BioPharma Dive

SkinBioTherapeutics targets the promising skin microbiome market – Proactive Investors UK

The life sciences firm studies how to enhance and reintroduce the good bacteria on the skin

() has set out to make the skin feel and look better by studying the bacteria that live on its surface.

While most people know about the importance of having a healthy gut microbiome, the benefits of reinforcing good bacteria [probiotics] to the skin are yet to be discovered by the wider public.

But its a promising path: according to a Fortune Business Insights, the global probiotics market will reach US$74.7bn by the end of 2025 and the skin is going to be at the forefront of this growth.

The life sciences firm was spun out from () in 2015 and Opti remains the majority shareholder with a 29.8% stake.

SkinBioTherapeutics proprietary technology SkinBiotix is patented in various countries and based on studies conducted by Catherine ONeill and Andrew McBain at The University of Manchester.

The AIM-listed company is exploring five avenues of development: medical biotics; pharmabiotics; access biotics; cosmetics; and cleanbiotics.

Medical focuses on wound healing while pharma is analysed for prescribed treatment for skin conditions.

The two have a longer development path due to the regulatory hurdles to be crossed.

Access biotics, though, has recently passed major milestone through a partnership with Dutch firm Winclove Probiotics to develop a food supplement to alleviate symptoms of psoriasis.

The product, called AxisBiotix, may be ready for the shelves within a year.

The pair, which started collaborating in February, have already came up with the first formulation and are ready to enter a study on humans eight months ahead of schedule.

The whole access biotics project is to look at the pathways, what happens in the gut and how it manifests on the skin, so there are multiple places we could have started from, eczema, acne or psoriasis, chief executive Stuart Ashman told Proactive.

We chose psoriasis because its a particularly aggressive condition, it affects about 3% of the global population and there is no cure.

Many sufferers have had to enter complete coronavirus isolation because they take immunosuppressants to control the psoriasis outbreaks.

During a global pandemic the last thing in the world is suppress your immune system, you actually want that firing on all cylinders, so we firmly believe that its very, very important to get this into the community as quickly as possible, Ashman added.

Elsewhere,Ashmans team have been working with speciality chemical producer () since November to design and manufacture ingredients for the cosmetics market.

The initial target was enhancing the barrier effect of the skin to stop infections, but during the human safety studies the researchers came across significant anti-ageing indications, too.

The life sciences firm is providing its technology to the FTSE 100 companys unit Sederma, while SkinBioTherapeutics gets access to Sedermas huge base of customers, including prestigious brands such as Chanel, Garnier and LOreal.

Sederma has slowly restarted operations following a halt at the beginning of lockdowns, though there has been no material delay on their joint work.

Finally, infection control in both the home and the hospital environment has also taken on a new degree of urgency following the COVID-19 outbreak.

The skin is a very complicated surface, but it is just a surface, so we are doing the same thing on a non-living surfaces such as an operating table or bedsheets, explained Ashman.

In this application, the scientists are looking at how they can prevent the latching of bad bacteria onto surfaces.

Looking at the numbers, SkinBioTherapeutics is currently in the research and development phase, so its still pre-revenue.

First sales are estimated to come in around two years, which would be November 2021 for the deal with Croda and February 2022 for Winclove, although the timeline for the latter has now compressed significantly.

Cash at the end of June was around 2.1mln.

At current cash burn we do have a two-year window however, as we commence commercialisation and we start new rapid access trials, we will start burning cash a little faster, Ashman concluded.

Its going to be very busy. Regardless of what Covid-19 throws at us, we are looking to find all routes possible to get this psoriasis product into the hands of those that need it and progress on the other areas.

At 19.4p, the company is valued at 25mln.

More here:

SkinBioTherapeutics targets the promising skin microbiome market - Proactive Investors UK