Induced pluripotent stem cell – Wikipedia

Pluripotent stem cell generated directly from a somatic cell

Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell. The iPSC technology was pioneered by Shinya Yamanaka's lab in Kyoto, Japan, who showed in 2006 that the introduction of four specific genes (named Myc, Oct3/4, Sox2 and Klf4), collectively known as Yamanaka factors, encoding transcription factors could convert somatic cells into pluripotent stem cells.[1] He was awarded the 2012 Nobel Prize along with Sir John Gurdon "for the discovery that mature cells can be reprogrammed to become pluripotent."[2]

Pluripotent stem cells hold promise in the field of regenerative medicine.[3] Because they can propagate indefinitely, as well as give rise to every other cell type in the body (such as neurons, heart, pancreatic, and liver cells), they represent a single source of cells that could be used to replace those lost to damage or disease.

The most well-known type of pluripotent stem cell is the embryonic stem cell. However, since the generation of embryonic stem cells involves destruction (or at least manipulation)[4] of the pre-implantation stage embryo, there has been much controversy surrounding their use. Patient-matched embryonic stem cell lines can now be derived using somatic cell nuclear transfer (SCNT).

Since iPSCs can be derived directly from adult tissues, they not only bypass the need for embryos, but can be made in a patient-matched manner, which means that each individual could have their own pluripotent stem cell line. These unlimited supplies of autologous cells could be used to generate transplants without the risk of immune rejection. While the iPSC technology has not yet advanced to a stage where therapeutic transplants have been deemed safe, iPSCs are readily being used in personalized drug discovery efforts and understanding the patient-specific basis of disease.[5]

Yamanaka named iPSCs with a lower case "i" due to the popularity of the iPod and other products.[7][8][9][10][dubious discuss]

In his Nobel seminar, Yamanaka cited the earlier seminal work of Harold Weintraub on the role of myoblast determination protein 1 (MyoD) in reprogramming cell fate to a muscle lineage as an important precursor to the discovery of iPSCs.[11]

iPSCs are typically derived by introducing products of specific sets of pluripotency-associated genes, or "reprogramming factors", into a given cell type. The original set of reprogramming factors (also dubbed Yamanaka factors) are the transcription factors Oct4 (Pou5f1), Sox2, Klf4 and cMyc. While this combination is most conventional in producing iPSCs, each of the factors can be functionally replaced by related transcription factors, miRNAs, small molecules, or even non-related genes such as lineage specifiers.[12]It is also clear that pro-mitotic factors such as C-MYC/L-MYC or repression of cell cycle checkpoints, such as p53, are conduits to creating a compliant cellular state for iPSC reprograming .[13]

iPSC derivation is typically a slow and inefficient process, taking 12 weeks for mouse cells and 34 weeks for human cells, with efficiencies around 0.010.1%. However, considerable advances have been made in improving the efficiency and the time it takes to obtain iPSCs. Upon introduction of reprogramming factors, cells begin to form colonies that resemble pluripotent stem cells, which can be isolated based on their morphology, conditions that select for their growth, or through expression of surface markers or reporter genes.

Induced pluripotent stem cells were first generated by Shinya Yamanaka's team at Kyoto University, Japan, in 2006.[1] They hypothesized that genes important to embryonic stem cell (ESC) function might be able to induce an embryonic state in adult cells. They chose twenty-four genes previously identified as important in ESCs and used retroviruses to deliver these genes to mouse fibroblasts. The fibroblasts were engineered so that any cells reactivating the ESC-specific gene, Fbx15, could be isolated using antibiotic selection.

Upon delivery of all twenty-four factors, ESC-like colonies emerged that reactivated the Fbx15 reporter and could propagate indefinitely. To identify the genes necessary for reprogramming, the researchers removed one factor at a time from the pool of twenty-four. By this process, they identified four factors, Oct4, Sox2, cMyc, and Klf4, which were each necessary and together sufficient to generate ESC-like colonies under selection for reactivation of Fbx15.

In June 2007, three separate research groups, including that of Yamanaka's, a Harvard/University of California, Los Angeles collaboration, and a group at MIT, published studies that substantially improved on the reprogramming approach, giving rise to iPSCs that were indistinguishable from ESCs. Unlike the first generation of iPSCs, these second generation iPSCs produced viable chimeric mice and contributed to the mouse germline, thereby achieving the 'gold standard' for pluripotent stem cells.

These second-generation iPSCs were derived from mouse fibroblasts by retroviral-mediated expression of the same four transcription factors (Oct4, Sox2, cMyc, Klf4). However, instead of using Fbx15 to select for pluripotent cells, the researchers used Nanog, a gene that is functionally important in ESCs. By using this different strategy, the researchers created iPSCs that were functionally identical to ESCs.[14][15][16][17]

Reprogramming of human cells to iPSCs was reported in November 2007 by two independent research groups: Shinya Yamanaka of Kyoto University, Japan, who pioneered the original iPSC method, and James Thomson of University of Wisconsin-Madison who was the first to derive human embryonic stem cells. With the same principle used in mouse reprogramming, Yamanaka's group successfully transformed human fibroblasts into iPSCs with the same four pivotal genes, Oct4, Sox2, Klf4, and cMyc, using a retroviral system,[18] while Thomson and colleagues used a different set of factors, Oct4, Sox2, Nanog, and Lin28, using a lentiviral system.[19]

Obtaining fibroblasts to produce iPSCs involves a skin biopsy, and there has been a push towards identifying cell types that are more easily accessible.[20][21] In 2008, iPSCs were derived from human keratinocytes, which could be obtained from a single hair pluck.[22][23] In 2010, iPSCs were derived from peripheral blood cells,[24][25] and in 2012, iPSCs were made from renal epithelial cells in the urine.[26]

Other considerations for starting cell type include mutational load (for example, skin cells may harbor more mutations due to UV exposure),[20][21] time it takes to expand the population of starting cells,[20] and the ability to differentiate into a given cell type.[27]

[citation needed]

The generation of induced pluripotent cells is crucially dependent on the transcription factors used for the induction.

Oct-3/4 and certain products of the Sox gene family (Sox1, Sox2, Sox3, and Sox15) have been identified as crucial transcriptional regulators involved in the induction process whose absence makes induction impossible. Additional genes, however, including certain members of the Klf family (Klf1, Klf2, Klf4, and Klf5), the Myc family (c-myc, L-myc, and N-myc), Nanog, and LIN28, have been identified to increase the induction efficiency.

Although the methods pioneered by Yamanaka and others have demonstrated that adult cells can be reprogrammed to iPS cells, there are still challenges associated with this technology:

The table on the right summarizes the key strategies and techniques used to develop iPS cells in the first five years after Yamanaka et al.'s 2006 breakthrough. Rows of similar colors represent studies that used similar strategies for reprogramming.

One of the main strategies for avoiding problems (1) and (2) has been to use small molecules that can mimic the effects of transcription factors. These compounds can compensate for a reprogramming factor that does not effectively target the genome or fails at reprogramming for another reason; thus they raise reprogramming efficiency. They also avoid the problem of genomic integration, which in some cases contributes to tumor genesis. Key studies using such strategy were conducted in 2008. Melton et al. studied the effects of histone deacetylase (HDAC) inhibitor valproic acid. They found that it increased reprogramming efficiency 100-fold (compared to Yamanaka's traditional transcription factor method).[42] The researchers proposed that this compound was mimicking the signaling that is usually caused by the transcription factor c-Myc. A similar type of compensation mechanism was proposed to mimic the effects of Sox2. In 2008, Ding et al. used the inhibition of histone methyl transferase (HMT) with BIX-01294 in combination with the activation of calcium channels in the plasma membrane in order to increase reprogramming efficiency.[43] Deng et al. of Beijing University reported in July 2013 that induced pluripotent stem cells can be created without any genetic modification. They used a cocktail of seven small-molecule compounds including DZNep to induce the mouse somatic cells into stem cells which they called CiPS cells with the efficiency at 0.2% comparable to those using standard iPSC production techniques. The CiPS cells were introduced into developing mouse embryos and were found to contribute to all major cells types, proving its pluripotency.[44][45]

Ding et al. demonstrated an alternative to transcription factor reprogramming through the use of drug-like chemicals. By studying the MET (mesenchymal-epithelial transition) process in which fibroblasts are pushed to a stem-cell like state, Ding's group identified two chemicals ALK5 inhibitor SB431412 and MEK (mitogen-activated protein kinase) inhibitor PD0325901 which was found to increase the efficiency of the classical genetic method by 100 fold. Adding a third compound known to be involved in the cell survival pathway, Thiazovivin further increases the efficiency by 200 fold. Using the combination of these three compounds also decreased the reprogramming process of the human fibroblasts from four weeks to two weeks.[46][47]

In April 2009, it was demonstrated that generation of iPS cells is possible without any genetic alteration of the adult cell: a repeated treatment of the cells with certain proteins channeled into the cells via poly-arginine anchors was sufficient to induce pluripotency.[48] The acronym given for those iPSCs is piPSCs (protein-induced pluripotent stem cells).

Another key strategy for avoiding problems such as tumorgenesis and low throughput has been to use alternate forms of vectors: adenovirus, plasmids, and naked DNA or protein compounds.

In 2008, Hochedlinger et al. used an adenovirus to transport the requisite four transcription factors into the DNA of skin and liver cells of mice, resulting in cells identical to ESCs. The adenovirus is unique from other vectors like viruses and retroviruses because it does not incorporate any of its own genes into the targeted host and avoids the potential for insertional mutagenesis.[43] In 2009, Freed et al. demonstrated successful reprogramming of human fibroblasts to iPS cells.[49] Another advantage of using adenoviruses is that they only need to present for a brief amount of time in order for effective reprogramming to take place.

Also in 2008, Yamanaka et al. found that they could transfer the four necessary genes with a plasmid.[35] The Yamanaka group successfully reprogrammed mouse cells by transfection with two plasmid constructs carrying the reprogramming factors; the first plasmid expressed c-Myc, while the second expressed the other three factors (Oct4, Klf4, and Sox2). Although the plasmid methods avoid viruses, they still require cancer-promoting genes to accomplish reprogramming. The other main issue with these methods is that they tend to be much less efficient compared to retroviral methods. Furthermore, transfected plasmids have been shown to integrate into the host genome and therefore they still pose the risk of insertional mutagenesis. Because non-retroviral approaches have demonstrated such low efficiency levels, researchers have attempted to effectively rescue the technique with what is known as the PiggyBac Transposon System. Several studies have demonstrated that this system can effectively deliver the key reprogramming factors without leaving footprint mutations in the host cell genome. The PiggyBac Transposon System involves the re-excision of exogenous genes, which eliminates the issue of insertional mutagenesis.[citation needed]

In January 2014, two articles were published claiming that a type of pluripotent stem cell can be generated by subjecting the cells to certain types of stress (bacterial toxin, a low pH of 5.7, or physical squeezing); the resulting cells were called STAP cells, for stimulus-triggered acquisition of pluripotency.[50]

In light of difficulties that other labs had replicating the results of the surprising study, in March 2014, one of the co-authors has called for the articles to be retracted.[51] On 4 June 2014, the lead author, Obokata agreed to retract both the papers [52] after she was found to have committed 'research misconduct' as concluded in an investigation by RIKEN on 1 April 2014.[53]

MicroRNAs are short RNA molecules that bind to complementary sequences on messenger RNA and block expression of a gene. Measuring variations in microRNA expression in iPS cells can be used to predict their differentiation potential.[54] Addition of microRNAs can also be used to enhance iPS potential. Several mechanisms have been proposed.[54] ES cell-specific microRNA molecules (such as miR-291, miR-294 and miR-295) enhance the efficiency of induced pluripotency by acting downstream of c-Myc.[55] microRNAs can also block expression of repressors of Yamanaka's four transcription factors, and there may be additional mechanisms induce reprogramming even in the absence of added exogenous transcription factors.[54]

Induced pluripotent stem cells are similar to natural pluripotent stem cells, such as embryonic stem cells, in many aspects, such as the expression of certain stem cell genes and proteins, chromatin methylation patterns, doubling time, embryoid body formation, teratoma formation, viable chimera formation, and potency and differentiability, but the full extent of their relation to natural pluripotent stem cells is still being assessed.[1]

Gene expression and genome-wide H3K4me3 and H3K27me3 were found to be extremely similar between ES and iPS cells.[56][citation needed] The generated iPSCs were remarkably similar to naturally isolated pluripotent stem cells (such as mouse and human embryonic stem cells, mESCs and hESCs, respectively) in the following respects, thus confirming the identity, authenticity, and pluripotency of iPSCs to naturally isolated pluripotent stem cells:

Recent achievements and future tasks for safe iPSC-based cell therapy are collected in the review of Okano et al.[67]

The task of producing iPS cells continues to be challenging due to the six problems mentioned above. A key tradeoff to overcome is that between efficiency and genomic integration. Most methods that do not rely on the integration of transgenes are inefficient, while those that do rely on the integration of transgenes face the problems of incomplete reprogramming and tumor genesis, although a vast number of techniques and methods have been attempted. Another large set of strategies is to perform a proteomic characterization of iPS cells.[58] Further studies and new strategies should generate optimal solutions to the five main challenges. One approach might attempt to combine the positive attributes of these strategies into an ultimately effective technique for reprogramming cells to iPS cells.

Another approach is the use of iPS cells derived from patients to identify therapeutic drugs able to rescue a phenotype. For instance, iPS cell lines derived from patients affected by ectodermal dysplasia syndrome (EEC), in which the p63 gene is mutated, display abnormal epithelial commitment that could be partially rescued by a small compound.[68]

An attractive feature of human iPS cells is the ability to derive them from adult patients to study the cellular basis of human disease. Since iPS cells are self-renewing and pluripotent, they represent a theoretically unlimited source of patient-derived cells which can be turned into any type of cell in the body. This is particularly important because many other types of human cells derived from patients tend to stop growing after a few passages in laboratory culture. iPS cells have been generated for a wide variety of human genetic diseases, including common disorders such as Down syndrome and polycystic kidney disease.[69][70] In many instances, the patient-derived iPS cells exhibit cellular defects not observed in iPS cells from healthy subjects, providing insight into the pathophysiology of the disease.[71] An international collaborated project, StemBANCC, was formed in 2012 to build a collection of iPS cell lines for drug screening for a variety of disease. Managed by the University of Oxford, the effort pooled funds and resources from 10 pharmaceutical companies and 23 universities. The goal is to generate a library of 1,500 iPS cell lines which will be used in early drug testing by providing a simulated human disease environment.[72] Furthermore, combining hiPSC technology and small molecule or genetically encoded voltage and calcium indicators provided a large-scale and high-throughput platform for cardiovascular drug safety screening.[73][74][75][76]

A proof-of-concept of using induced pluripotent stem cells (iPSCs) to generate human organ for transplantation was reported by researchers from Japan. Human 'liver buds' (iPSC-LBs) were grown from a mixture of three different kinds of stem cells: hepatocytes (for liver function) coaxed from iPSCs; endothelial stem cells (to form lining of blood vessels) from umbilical cord blood; and mesenchymal stem cells (to form connective tissue). This new approach allows different cell types to self-organize into a complex organ, mimicking the process in fetal development. After growing in vitro for a few days, the liver buds were transplanted into mice where the 'liver' quickly connected with the host blood vessels and continued to grow. Most importantly, it performed regular liver functions including metabolizing drugs and producing liver-specific proteins. Further studies will monitor the longevity of the transplanted organ in the host body (ability to integrate or avoid rejection) and whether it will transform into tumors.[77][78] Using this method, cells from one mouse could be used to test 1,000 drug compounds to treat liver disease, and reduce animal use by up to 50,000.[79]

In 2021, a switchable Yamanaka factors-reprogramming-based approach for regeneration of damaged heart without tumor-formation was demonstrated in mice and was successful if the intervention was carried out immediately before or after a heart attack.[80]

Embryonic cord-blood cells were induced into pluripotent stem cells using plasmid DNA. Using cell surface endothelial/pericytic markers CD31 and CD146, researchers identified 'vascular progenitor', the high-quality, multipotent vascular stem cells. After the iPS cells were injected directly into the vitreous of the damaged retina of mice, the stem cells engrafted into the retina, grew and repaired the vascular vessels.[81][82]

Labelled iPSCs-derived NSCs injected into laboratory animals with brain lesions were shown to migrate to the lesions and some motor function improvement was observed.[83]

Beating cardiac muscle cells, iPSC-derived cardiomyocytes, can be mass-produced using chemically defined differentiation protocols.[84][85] These protocols typically modulate the same developmental signaling pathways required for heart development .[86] These iPSC-cardiomyocytes can recapitulate genetic arrhythmias and cardiac drug responses, since they exhibit the same genetic background as the patient from which they were derived.[87][88][89]

In June 2014, Takara Bio received technology transfer from iHeart Japan, a venture company from Kyoto University's iPS Cell Research Institute, to make it possible to exclusively use technologies and patents that induce differentiation of iPS cells into cardiomyocytes in Asia. The company announced the idea of selling cardiomyocytes to pharmaceutical companies and universities to help develop new drugs for heart disease.[90]

On March 9, 2018, the Specified Regenerative Medicine Committee of Osaka University officially approved the world's first clinical research plan to transplant a "myocardial sheet" made from iPS cells into the heart of patients with severe heart failure. Osaka University announced that it had filed an application with the Ministry of Health, Labor and Welfare on the same day.

On May 16, 2018, the clinical research plan was approved by the Ministry of Health, Labor and Welfare's expert group with a condition.[91][92]

In October 2019, a group at Okayama University developed a model of ischemic heart disease using cardiomyocytes differentiated from iPS cells.[93]

Although a pint of donated blood contains about two trillion red blood cells and over 107 million blood donations are collected globally, there is still a critical need for blood for transfusion. In 2014, type O red blood cells were synthesized at the Scottish National Blood Transfusion Service from iPSC. The cells were induced to become a mesoderm and then blood cells and then red blood cells. The final step was to make them eject their nuclei and mature properly. Type O can be transfused into all patients. Human clinical trials were not expected to begin before 2016.[94]

The first human clinical trial using autologous iPSCs was approved by the Japan Ministry Health and was to be conducted in 2014 at the Riken Center for Developmental Biology in Kobe. However the trial was suspended after Japan's new regenerative medicine laws came into effect in November 2015.[95] More specifically, an existing set of guidelines was strengthened to have the force of law (previously mere recommendations).[96] iPSCs derived from skin cells from six patients with wet age-related macular degeneration were reprogrammed to differentiate into retinal pigment epithelial (RPE) cells. The cell sheet would be transplanted into the affected retina where the degenerated RPE tissue was excised. Safety and vision restoration monitoring were to last one to three years.[97][98]

In March 2017, a team led by Masayo Takahashi completed the first successful transplant of iPS-derived retinal cells from a donor into the eye of a person with advanced macular degeneration.[99] However it was reported that they are now having complications.[100] The benefits of using autologous iPSCs are that there is theoretically no risk of rejection and that it eliminates the need to use embryonic stem cells. However, these iPSCs were derived from another person.[98]

New clinical trials involving iPSCs are now ongoing not only in Japan, but also in the US and Europe.[101] Research in 2021 on the trial registry Clinicaltrials.gov identified 129 trial listings mentioning iPSCs, but most were non-interventional.[102]

To make iPSC-based regenerative medicine technologies available to more patients, it is necessary to create universal iPSCs that can be transplanted independently of haplotypes of HLA. The current strategy for the creation of universal iPSCs has two main goals: to remove HLA expression and to prevent NK cells attacks due to deletion of HLA. Deletion of the B2M and CIITA genes using the CRISPR/Cas9 system has been reported to suppress the expression of HLA class I and class II, respectively. To avoid NK cell attacks. transduction of ligands inhibiting NK-cells, such as HLA-E and CD47 has been used.[103] HLA-C is left unchanged, since the 12 common HLA-C alleles are enough to cover 95% of the world's population.[103]

A multipotent mesenchymal stem cell, when induced into pluripotence, holds great promise to slow or reverse aging phenotypes. Such anti-aging properties were demonstrated in early clinical trials in 2017.[104] In 2020, Stanford University researchers concluded after studying elderly mice that old human cells when subjected to the Yamanaka factors, might rejuvenate and become nearly indistinguishable from their younger counterparts.[105]

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Induced pluripotent stem cell - Wikipedia

Twenty-fifth Amendment to the United States Constitution

1967 amendment enumerating presidential succession

The Twenty-fifth Amendment (Amendment XXV) to the United States Constitution deals with presidential succession and disability.

It clarifies that the vice president becomes president if the president dies, resigns, or is removed from office, and establishes how a vacancy in the office of the vice president can be filled.It also provides for the temporary transfer of the president's powers and duties to the vice president, either on the initiative of the president alone or on the initiative of the vice president together with a majority of the president's cabinet. In either case, the vice president becomes acting president until the presidential powers and duties are returned to the president.

The amendment was submitted to the states on July 6, 1965, by the 89th Congress and was adopted on February 10, 1967, the day that the requisite number of states (38) had ratified it.[1]

Section 1. In case of the removal of the President from office or of his death or resignation, the Vice President shall become President.

Section 1 clarifies that in the enumerated situations the vice president becomes president, instead of merely assuming the powers and duties of the presidency as acting president.[2] It operates automatically, without needing to be explicitly invoked.[3]:108

Section 2. Whenever there is a vacancy in the office of the Vice President, the President shall nominate a Vice President who shall take office upon confirmation by a majority vote of both Houses of Congress.

Section 2 provides a mechanism for filling a vacancy in the vice presidency. Before the Twenty-fifth Amendment, a vice presidential vacancy continued until a new vice president took office at the start of the next presidential term; the vice presidency had become vacant several times due to death, resignation, or succession to the presidency, and these vacancies had often lasted several years.[2]

Section 3. Whenever the President transmits to the President pro tempore of the Senate and the Speaker of the House of Representatives his written declaration that he is unable to discharge the powers and duties of his office, and until he transmits to them a written declaration to the contrary, such powers and duties shall be discharged by the Vice President as Acting President.

Section 3 allows for the voluntary transfer of presidential authority to the vice president (for example, in anticipation of a medical procedure) by the president declaring in writing to be unable to discharge the powers and duties of the presidency. The vice president then assumes those powers and duties as acting president;[note 1] the vice president does not become president and the president remains in office, although without authority. The president regains those powers and duties upon declaring, in writing, to be again able to discharge them.[3]:112-3

Section 4. Whenever the Vice President and a majority of either the principal officers of the executive departments or of such other body as Congress may by law provide, transmit to the President pro tempore of the Senate and the Speaker of the House of Representatives their written declaration that the President is unable to discharge the powers and duties of his office, the Vice President shall immediately assume the powers and duties of the office as Acting President.

Thereafter, when the President transmits to the President pro tempore of the Senate and the Speaker of the House of Representatives his written declaration that no inability exists, he shall resume the powers and duties of his office unless the Vice President and a majority of either the principal officers of the executive department[note 2][7] or of such other body as Congress may by law provide, transmit within four days to the President pro tempore of the Senate and the Speaker of the House of Representatives their written declaration that the President is unable to discharge the powers and duties of his office. Thereupon Congress shall decide the issue, assembling within forty-eight hours for that purpose if not in session. If the Congress, within twenty-one days after receipt of the latter written declaration, or, if Congress is not in session, within twenty-one days after Congress is required to assemble, determines by two-thirds vote of both Houses that the President is unable to discharge the powers and duties of his office, the Vice President shall continue to discharge the same as Acting President; otherwise, the President shall resume the powers and duties of his office.[8]

Section 4 addresses the case of a president who is unable to discharge the powers and duties of the presidency but cannot, or does not, execute the voluntary declaration contemplated by Section3.[3]:117 It allows the vice president, together with a "majority of either the principal officers of the executive departments or of such other body as Congress may by law provide",[note 3] to issue a written declaration that the president is unable to discharge his duties. Immediately upon such a declaration being sent to Congress, the vice president becomes acting president[note 4]while (as with Section3) the president remains in office, albeit temporarily divested of authority.[9]

John Feerick, the principal drafter of the amendment,[3]:xii,xx[4]:5[10] writes that Congress deliberately left the terms unable and inability undefined "since cases of inability could take various forms not neatly fitting into [a rigid] definition... The debates surrounding the Twenty-fifth Amendment indicate that [those terms] are intended to cover all cases in which some condition or circumstance prevents the President from discharging his powers and duties..."[3]:112A survey of scholarship on the amendment found

no specific threshold medical or otherwise for the "inability" contemplated in Section4. The framers specifically rejected any definition of the term, prioritizing flexibility. Those implementing Section4 should focus on whether in an objective sense taking all of the circumstances into account the President is "unable to discharge the powers and duties" of the office. The amendment does not require that any particular type or amount of evidence be submitted to determine that the President is unable to perform his duties. While the framers did imagine that medical evidence would be helpful to the determination of whether the President is unable, neither medical expertise nor diagnosis is required for a determination of inability... To be sure, foremost in [the minds of the framers] was a physical or mental impairment. But the text of Section4 sets forth a flexible standard intentionally designed to apply to a wide variety of unforeseen emergencies.[4]:7,20

Among potential examples of such unforeseen emergencies, legal scholars have listed kidnapping of the president and "political emergencies" such as impeachment.Traits such as unpopularity, incompetence, impeachable conduct, poor judgment, or laziness might not in and of themselves constitute inability, but should such traits "rise to a level where they prevented the President from carrying out his or her constitutional duties, they still might constitute an inability, even in the absence of a formal medical diagnosis." In addition, a president who already manifested disabling traits at the time he or she was elected is not thereby immunized from a declaration of inability.[4]:21n63,22n67

The "principal officers of the executive departments" are the fifteen Cabinet members enumerated in the United States Code at 5U.S.C.101:[11][12]

Acting secretaries can participate in issuing the declaration.[3]:117-8[4]:13

If the president subsequently issues a declaration claiming to be able, then a four-day period begins during which the vice president remains acting president.[3]:118-9[4]:38n137If by the end of this period the vice president and a majority of the "principal officers" have not issued a second declaration of the president's inability, then the president resumes his powers and duties; but if they do issue a second declaration within the four days, then the vice president remains acting president while Congress considers the matter. Then if within 21 days the Senate and the House determine, each by a two-thirds vote, that the president is unable, then the vice president continues as acting president; otherwise the president resumes his powers and duties.[note 5]

Section 4's requirement of a two-thirds vote of the House and a two-thirds vote of the Senate is more strict than the Constitution's requirement for impeachment and removal of the president for "high crimes and misdemeanors" a majority of the House followed by two-thirds of the Senate.[3]:120n[14][15][16]In addition, an impeached president retains his authority unless and until the Senate votes to remove him or her at the end of an impeachment trial; in contrast, should Congress be called upon to decide the question of the president's ability or inability under Section4, presidential authority remains in the hands of the vice president (as acting president) unless and until the question is resolved in the president's favor.[3]:11820

ArticleII, Section1, Clause6 of the Constitution reads:

In Case of the Removal of the President from Office, or of his Death, Resignation, or Inability to discharge the Powers and Duties of the said Office, the Same shall devolve on the Vice President...

This provision is ambiguous as to whether, in the enumerated circumstances, the vice president becomes the president, or merely assumes the "powers and duties" of the presidency. It also fails to define what constitutes inability, or how questions concerning inability are to be resolved.[17] The Twenty-fifth Amendment addressed these deficiencies.[2] The ambiguities in ArticleII, Section1, Clause6 of the Constitution regarding death, resignation, removal, or disability of the president created difficulties several times:

The 1951 novel The Caine Mutiny and its 1954 film version influenced the drafters of the amendment. John D. Feerick told The Washington Post in 2018 that the film was a live depiction of the type of crisis that could arise "if a president ever faced questions about physical or mental inabilities but disagreed completely with the judgment", which was not dealt with in the Constitution. Lawmakers and lawyers drafting the amendment wanted no such "Article 184 situation" as depicted in the film, in which the Vice President of the U.S. or others could topple the President by merely saying that the President was "disabled".[25]

In 1963, Senator Kenneth Keating of New York proposed a Constitutional amendment which would have enabled Congress to enact legislation providing for how to determine when a president is unable to discharge the powers and duties of the presidency, rather than, as the Twenty-fifth Amendment does, having the Constitution so provide.[26]:345 This proposal was based upon a recommendation of the American Bar Association in 1960.[26]:27

The text of the proposal read:[26]:350

In case of the removal of the President from office or of his death or resignation, the said office shall devolve on the Vice President. In case of the inability of the President to discharge the powers and duties of the said office, the said powers and duties shall devolve on the Vice President, until the inability be removed. The Congress may by law provide for the case of removal, death, resignation or inability, both of the President and Vice President, declaring what officer shall then be President, or, in case of inability, act as President, and such officer shall be or act as President accordingly, until a President shall be elected or, in case of inability, until the inability shall be earlier removed. The commencement and termination of any inability shall be determined by such method as Congress shall by law provide.

Senators raised concerns that the Congress could either abuse such authority,[26]:30 or neglect to enact any such legislation after the adoption of this proposal.[26]:3435 Tennessee senator Estes Kefauver, the Chairman of the Senate Judiciary Committee's Subcommittee on Constitutional Amendments, a long-time advocate for addressing the disability question, spearheaded the effort until he died in August 1963.[26]:28 Senator Keating was defeated in the 1964 election, but Senator Roman Hruska of Nebraska took up Keating's cause as a new member of the Subcommittee on Constitutional Amendments.[24]

By the 1960s, medical advances had made increasingly plausible that an injured or ill president might live a long time while incapacitated. The assassination of John F. Kennedy in 1963 underscored the need for a clear procedure for determining presidential disability,[27] particularly since the new president, Lyndon Johnson, had once suffered a heart attack[28] and with the office of vice president to remain vacant until the next term began on January 20, 1965 the next two people in the line of succession were the 71-year-old speaker of the House John McCormack[27][29] and the 86-year-old Senate president pro tempore Carl Hayden.[27][29] Senator Birch Bayh succeeded Kefauver as Chairman of the Subcommittee on Constitutional Amendments and set about advocating for a detailed amendment dealing with presidential disability.[27]

On January 6, 1965, Senator Birch Bayh proposed S.J. Res.1 in the Senate and Representative Emanuel Celler (Chairman of the House Judiciary Committee) proposed H.J. Res.1 in the House of Representatives. Their proposal specified the process by which a president could be declared "unable to discharge the powers and duties of his office", thereby making the vice president an acting president, and how the president could regain the powers of their office. Also, their proposal provided a way to fill a vacancy in the office of vice president before the next presidential election. This was as opposed to the KeatingKefauver proposal, which neither provided for filling a vacancy in the office of vice president prior to the next presidential election, nor provided a process for determining presidential disability. In 1964, the American Bar Association endorsed the type of proposal which Bayh and Celler advocated.[26]:348350 On January 28, 1965, President Johnson endorsed S.J. Res.1 in a statement to Congress.[24] Their proposal received bipartisan support.[5]:6

On February 19, the Senate passed the amendment, but the House passed a different version of the amendment on April13. On April22 it was returned to the Senate with revisions.[24] There were four areas of disagreement between the House and Senate versions:

On July 6, after a conference committee ironed out differences between the versions,[30] the final version of the amendment was passed by both Houses of the Congress and presented to the states for ratification.[26]:354358

Nebraska was the first state to ratify, on July12, 1965, and ratification became complete when Nevada became the 38th state to ratify, on February10, 1967.[note 6]

When President Lyndon B. Johnson underwent planned surgery in 1965, he was unable to temporarily transfer power to Vice President Hubert H. Humphrey because ratification remained incomplete. On February23, 1967, at the White House ceremony certifying the ratification, Johnson said:

It was 180 years ago, in the closing days of the Constitutional Convention, that the Founding Fathers debated the question of Presidential disability. John Dickinson of Delaware asked this question: "What is the extent of the term 'disability' and who is to be the judge of it?" No one replied. It is hard to believe that until last week our Constitution provided no clear answer. Now, at last, the 25th amendment clarifies the crucial clause that provides for succession to the Presidency and for filling a Vice Presidential vacancy.[33]

On October 10, 1973, Vice President Spiro Agnew resigned; two days later President Richard Nixon nominated Representative Gerald Ford to replace Agnew as new vice president pursuant to Section2. Ford was confirmed by the Senate and the House on November27 and December6 respectively, and sworn in December6.[34]

On August 9, 1974 Nixon resigned and Ford became president under Section1; Ford is the only president to have been elected neither president nor vice president.[35]The office of vice president was thus again vacant, and on August20 President Ford nominated former New York governor Nelson Rockefeller.[3]:167169 Rockefeller was confirmed by the Senate and the House on December 10 and 19 respectively, and sworn in December 19.[3]:186187

Feerick writes that the Twenty-fifth Amendment helped pave the way for Nixon's resignation during the Watergate scandal. Nixon and Agnew were Republicans, and in the months immediately following Agnew's resignation, with the vice presidency empty, removal or resignation of Nixon would have transferred the presidential powers to House Speaker Carl Albert, a Democrat. But once Ford (a Republican) became vice president under Section 2, removal of Nixon became more palatable because it would, now, not result in a change in the party holding the presidency, and therefore "the momentum for exposing the truth about Nixon's involvement in Watergate increased."[3]:158

On December 22, 1978, President Jimmy Carter considered invoking Section3 in advance of hemorrhoid surgery.[36] Since then, presidents Ronald Reagan, George H. W. Bush, Bill Clinton, and Barack Obama also considered invoking Section3 at various times without doing so.[37]

On July 12, 1985, President Ronald Reagan underwent a colonoscopy and was diagnosed with bowel cancer. He elected to have the lesion removed immediately,[38] and consulted with White House counsel Fred Fielding about whether to invoke Section3, and in particular about whether doing so would set an undesirable precedent. Fielding and White House Chief of Staff Donald Regan recommended that Reagan transfer power, and two letters were drafted: one specifically invoking Section3, the other mentioning only that Reagan was mindful of its provisions. On July 13, Reagan signed the second letter[39] before being placed under general anesthesia for a colectomy,[40] and Vice President George H. W. Bush was acting president from 11:28a.m. until 7:22p.m., when Reagan transmitted a letter declaring himself able to resume his duties.[41]

In the Fordham Law Review, commentator John Feerick asserted that although Reagan disclaimed any use of the Twenty-fifth Amendment in his letter (likely out of "fear of the reaction of the country and the world to a 'President' who admitted to being disabled, and concern ... [over] set[ting] a harmful precedent"), he followed the process set forth in Section3. Furthermore, Feerick noted that "no constitutional provision except the Twenty-Fifth Amendment would have allowed" him to designate the vice president as acting president. Reagan later stated in a memoir that he had, in fact, invoked the Twenty-fifth Amendment.[42]

On June 29, 2002, President George W. Bush explicitly invoked Section3 in temporarily transferring his powers to Vice President Dick Cheney before undergoing a colonoscopy, which began at 7:09a.m. Bush awoke about forty minutes later, but did not resume his presidential powers until 9:24a.m. to ensure any aftereffects had cleared.[39][43] According to his staff, Acting President Cheney held his regular national security and homeland security meetings with aides at the White House, but made no appearances and took no recorded actions while being acting president.[43]

In the view of commentator Adam Gustafson, this confident application of Section3 "rectified" President Reagan's "ambivalent invocation" and provided an example of a "smooth and temporary transition" under Section3 that paved the way for future applications. Together with the 2007 invocation, it established the reasonableness of invocation for relatively minor inabilities, promoting continuity in the Executive Branch.[44]

On July 21, 2007, Bush again invoked Section3 before another colonoscopy. Cheney was acting president from 7:16a.m. until 9:21a.m.[39] During that time, Vice President Cheney (as acting president) remained at home.[44] This 2007 invocation and the 2002 invocation received relatively little attention in the press overall.[44]

On November 19, 2021, President Joe Biden temporarily transferred his powers and duties to Vice President Kamala Harris before undergoing a colonoscopy, making her acting president from 10:10 a.m. until 11:35 a.m.[45][46] Harris is the first woman to hold the powers and duties of the U.S. presidency.[47][48]

Section 4 has never been invoked, though on several occasions its use was considered.

Following the attempted assassination of Ronald Reagan on March30, 1981, Vice President George H. W. Bush did not assume the presidential powers and duties as acting president. Reagan had been rushed into surgery with no opportunity to invoke Section3; Bush did not invoke Section4 because he was on a plane at the time of the shooting, and Reagan was out of surgery by the time Bush landed in Washington.[49] In 1995, Birch Bayh, the primary sponsor of the amendment in the Senate, wrote that Section4 should have been invoked.[50] Physician to the President Daniel Ruge, who supervised Reagan's treatment immediately after the shooting, said he had erred by not having Reagan invoke Section3 because the president needed general anesthesia and was in an intensive care unit.[51]

From the end of the 1980s onwards, Reagan's political opponents alleged that he showed signs of dementia.[52] According to Reagan biographer Edmund Morris, staffers to White House chief of staff Howard Baker intended to use their first meeting with Reagan in 1987 to evaluate whether he was "losing his mental grip". However, Reagan "came in stimulated by the press of all these new people and performed splendidly".[53][54][55]

Reagan was diagnosed with Alzheimer's disease in 1994, five years after leaving office.[56] The president told neurosurgeon Daniel Ruge, according to Ruge in 1980, that he expected doctors to test his memory, and promised to resign if it deteriorated. After the 1994 diagnosis, Ruge said he never found any sign of Alzheimer's while talking to him almost every day from 1981 to 1985.[51]

After President Donald Trump dismissed FBI director James Comey in May 2017, acting FBI director Andrew McCabe claimed that Deputy Attorney General Rod Rosenstein held high-level discussions within the Justice Department about approaching Vice President Mike Pence and the Cabinet about possibly invoking Section4.[57] Miles Taylor, who anonymously authored "I Am Part of the Resistance Inside the Trump Administration" and A Warning, also wrote that he and other aides considered approaching Pence to invoke the Twenty-fifth Amendment.[58] A spokesperson later said that Rosenstein denied pursuing the Twenty-fifth Amendment, and Pence strongly denied considering invoking Section4.[58][59] On March 15, 2019, Senator Lindsey Graham stated the Senate Judiciary Committee would investigate the discussions and seek related documents.[60]

After the storming of the United States Capitol on January 6, 2021, President Trump was accused of having incited the incident,[61][62][63] leading to several calls for Section4 to be invoked. Proponents included Representatives Ted Lieu and Charlie Crist, former Defense Secretary William Cohen, and the National Association of Manufacturers (which asked Vice President Pence to "seriously consider" invoking the amendment).[64] By evening, some of Trump's Cabinet members were also reportedly considering invoking Section4.[65] In a New York magazine article, law professor Paul Campos also supported using Section4 "immediately" and "for the good of the nation."[66] On January 7, incoming Senate majority leader Chuck Schumer and Speaker of the House of Representatives Nancy Pelosi also called for Section4 to be invoked.[67][68]

The following states have not ratified:

See the article here:

Twenty-fifth Amendment to the United States Constitution

Double Jeopardy Clause – Wikipedia

U.S. constitutional law preventing repeated punishment for the same crime

The Double Jeopardy Clause of the Fifth Amendment to the United States Constitution provides: "[N]or shall any person be subject for the same offence to be twice put in jeopardy of life or limb..."[1] The four essential protections included are prohibitions against, for the same offense:

Jeopardy attaches in jury trial when the jury is empaneled and sworn in, in a bench trial when the court begins to hear evidence after the first witness is sworn in, or when a court accepts a defendant's plea unconditionally.[2] Jeopardy does not attach in a retrial of a conviction that was reversed on appeal on procedural grounds (as opposed to evidentiary insufficiency grounds), in a retrial for which "manifest necessity" has been shown following a mistrial, and in the seating of another grand jury if the prior one refuses to return an indictment.

In United States v. Felix, the U.S. Supreme Court ruled: "a[n]...offense and a conspiracy to commit that offense are not the same offense for double jeopardy purposes."[3][4][5]

Sometimes the same conduct may violate different statutes. If all elements of a lesser offense are relied on to prove a greater offense, the two crimes are the "same offense" for double jeopardy purposes, and the doctrine will bar the second prosecution. This ruling in Felix distinguished between the test in Blockburger and the ruling in Grady v. Corbin regarding the "same conduct" vs "same offense" test, which was later overruled and completely reverted back to Blockburger in United States v. Dixon. In Blockburger v. United States, the Supreme Court held that "where the same act or transaction constitutes a violation of two distinct statutory provisions, the test to be applied to determine whether there are two offenses or only one, is whether each provision requires proof of an additional fact which the other does not".[6] The test was applied in Brown v. Ohio, where the defendant had first been convicted of operating an automobile without the owner's consent, and later of stealing the same automobile. The Supreme Court concluded that the same evidence was necessary to prove both offenses, and that in effect there was only one offense. Therefore, it overturned the second conviction.[7]

In other cases, the same conduct may constitute multiple offenses under the same statute, for instance where one robs many individuals at the same time. There is no explicit bar to separate prosecutions for different offenses arising under the same "criminal transaction", but it is not permissible for the prosecution to re-litigate facts already determined by a jury. In Ashe v. Swenson, the defendant was accused of robbing seven poker players during a game. John Ashe was first tried for, and acquitted of, robbing only one of the players; the defense did not contest that a robbery actually took place. The state then tried the defendant for robbing the second player; stronger identification evidence led to a conviction. The Supreme Court, however, overturned the conviction. It was held that in the first trial, since the defense had not presented any evidence that there was no robbery, the jury's acquittal had to be based on the conclusion that the defendant's alibi was valid. Since one jury had held that the defendant was not present at the crime scene, the State could not re-litigate the issue.[8]

Once acquitted, a defendant may not be retried for the same offense: "A verdict of acquittal, although not followed by any judgment, is a bar to a subsequent prosecution for the same offense."[9] Acquittal by directed verdict is also final and cannot be appealed by the prosecution.[10] An acquittal in a trial by judge (bench trial) is also generally not appealable by the prosecution.[11] A trial judge may normally enter an acquittal if he deems the evidence insufficient for conviction. If the judge makes this ruling before the jury reaches its verdict, the judge's determination is final. If, however, the judge overrules a conviction by the jury, the prosecution may appeal to have the conviction reinstated. Although a judge may overrule a guilty verdict by a jury, a judge does not have the same power to overrule a not guilty verdict.

More specifically, as stated in Ashe, "...when an issue of ultimate fact has once been determined by a valid and final judgment, that issue cannot again be litigated between the same parties in any future lawsuit."[12] Res judicata is a term of general application. Underneath that conceptual umbrella is the concept of collateral estoppel. As applied to double jeopardy, the court will use collateral estoppel as its basis for forming an opinion[citation needed].

Every charge has specific facts that must be proven beyond reasonable doubt to secure a conviction. And it is not unusual for a prosecutor to charge a person with "lesser included offenses". An oft-mentioned combination is first- and second-degree murder, with second-degree murder being the lesser offense. A person convicted on the lesser charge can never again be tried on the greater charge. If the conviction on the lesser charge is overturned, the greater charge does not then come back into play.

The Supreme Court ruled as such in Green v. United States, establishing the doctrine of "implied acquittal". Everett Green had been tried on charges of arson and first and second degree murder in the U.S. District Court for the District of Columbia. He was convicted on arson and the lesser offense of second degree murder. The verdict was silent on the greater offense. His conviction was overturned due to the appellate court deciding there wasn't enough evidence, remanding for a new trial. At the second trial, he was tried again with arson, first and second degree murder, convicted on the greater offense and sentenced to death.[13]

He appealed, claiming the second trial should not have included the greater offense under the Double Jeopardy Clause. The D.C. Circuit Court rejected the claim. The Supreme Court of the United States overruled, stating that Green was acquitted of first degree murder and, under the Fifth Amendment, could not be retried on that charge.

At Green's first trial, the jury was authorized to find him guilty of either first degree murder (killing while perpetrating a felony) or, alternatively, of second degree murder (killing with malice aforethought). The jury found him guilty of second degree murder, but, on his appeal, that conviction was reversed and the case remanded for a new trial. At this new trial, Green was tried again, not for second degree murder, but for first degree murder, even though the original jury had refused to find him guilty on that charge and it was in no way involved in his appeal. For the reasons stated hereafter, we conclude that this second trial for first degree murder placed Green in jeopardy twice for the same offense in violation of the Constitution.[14]

That the jury did not explicitly return an acquittal on first degree murder in its verdict is immaterial:

In brief, we believe this case can be treated no differently, for purposes of former jeopardy, than if the jury had returned a verdict which expressly read: "We find the defendant not guilty of murder in the first degree but guilty of murder in the second degree."[15]

This case did, in effect, overrule a preceding per curiam decision, that of Brantley v. Georgia.[16] In that case, the lesser charge was voluntary manslaughter and the greater charge was murder. Brantley was convicted on the lesser charge, but was convicted on the greater charge at retrial after the conviction was overturned. He appealed, arguing the inclusion of the greater charge at retrial violated the Double Jeopardy Clause. The Supreme Court rejected that argument: "It was not a case of twice in jeopardy under any view of the Constitution of the United States."

The Supreme Court explicitly overruled Brantley in another, near-identical case, Price v. Georgia:

While the Brantley holding may have had some vitality at the time the Georgia courts rendered their decisions in this case, it is no longer a viable authority and must now be deemed to have been overruled by subsequent decisions of this Court.[17]

The lesser and greater offenses in Price are identical to Brantley, with both being convicted on the lesser offense, and retried on the same charges as in the original trial after the conviction is overturned. Unlike Brantley, Price was convicted again on the lesser offense of voluntary manslaughter and given a similar sentence. Price appealed that conviction. The State of Georgia contended that since Price was not convicted on the greater offense at retrial, which was the case in Brantley, the second indictment constituted "harmless error". The Supreme Court rejected that idea:

The Double Jeopardy Clause, as we have noted, is cast in terms of the risk or hazard of trial and conviction, not of the ultimate legal consequences of the verdict. To be charged and to be subjected to a second trial for first-degree murder is an ordeal not to be viewed lightly. Further, and perhaps of more importance, we cannot determine whether or not the murder charge against petitioner induced the jury to find him guilty of the less serious offense of voluntary manslaughter rather than to continue to debate his innocence.[17]

Noting that the murder charge may have poisoned the jury against Price, the Supreme Court vacated the voluntary manslaughter conviction and remanded the case.

As double jeopardy applies only to charges that were the subject of an earlier final judgment, there are many situations in which it does not apply, despite the appearance of a retrial. For example, a second trial held after a mistrial does not violate the double jeopardy clause because a mistrial ends a trial prematurely without a judgment of guilty or not, as was decided by the Supreme Court in United States v. Perez.[18] Cases involuntarily dismissed because of insufficient evidence may constitute a final judgment for these purposes, though many state and federal laws allow for substantially limited prosecutorial appeals from these orders. Also, a retrial after a conviction that had been set aside upon a motion for new trial, and that subsequently has been reversed on appeal or vacated in a collateral proceeding (such as habeas corpus) would not violate double jeopardy, for the judgment in the first trial had been invalidated. In all of these cases, however, the previous trials do not entirely vanish. Testimony from them may be used in later retrials, such as to impeach contradictory testimony given at any subsequent proceeding.

Prosecutors may appeal when a trial judge sets aside a jury verdict for conviction with a judgment notwithstanding verdict for the defendant. A successful appeal by the prosecution would simply reinstate the jury verdict and so would not place the defendant at risk of another trial.

If a defendant appeals a conviction and is successful in having it overturned, the defendant may be subject to retrial.

Retrial is not possible if the verdict is overturned on the grounds of evidentiary insufficiency, rather than on the grounds of procedural faults. As noted above, if the trial court made a determination of evidentiary insufficiency, the determination would constitute a final acquittal; in Burks v. United States, the Court held that "it should make no difference that the reviewing court, rather than the trial court, determined the evidence to be insufficient."[19]

If the earlier trial is a fraud, double jeopardy will not prohibit a new trial because the party acquitted has prevented themselves from being placed into jeopardy to begin with. One such case is the trial of Harry Aleman, who was tried and acquitted in 1977 in Cook County, Illinois for the September 1972 death of William Logan. Nearly 20 years later, two persons under Federal Witness Protection came forward to state that Aleman murdered Logan and another individual, and also bribed the trial judge to return an acquittal.[20]

Following on the new evidence, the Cook County State's Attorney in December 1993 filed new charges alleging Aleman killed William Logan, an identical allegation for which Aleman had been previously acquitted. He was convicted on that charge and sentenced to 100 to 300 years in prison. He appealed that conviction and the indictment, challenging that the second prosecution was barred under the Double Jeopardy Clause. The Seventh Circuit disagreed, stating first that "jeopardy denotes risk", citing Breed v. Jones:

In the constitutional sense, jeopardy describes the risk that is traditionally associated with criminal prosecution.[21]

And also citing Serfass:

Without risk of a determination of guilt, jeopardy does not attach, and neither an appeal nor further prosecution constitutes double jeopardy In particular, it has no significance in this context unless jeopardy has once attached and an accused has been subjected to the risk of conviction.[22]

The Seventh Circuit declared that, in rejecting the Double Jeopardy claim, even with the slight risk of conviction following the bribe, Aleman still nullified any legitimate risk:

Aleman may be correct that some risk of conviction still existed after Judge Wilson agreed to fix the case, but it cannot be said that the risk was the sort "traditionally associated" with an impartial criminal justice system.[23]

The Double Jeopardy Clause of the Fifth Amendment does not attach in a grand jury proceeding, or bar a grand jury from returning an indictment when a prior grand jury has refused to do so.[24]

A person who is convicted of one set of charges cannot in general be tried on additional charges related to the crime unless said additional charges cover new facts against which the person in question has not yet been acquitted or convicted. The test that determines whether this can occur is the Blockburger test.

An example of this are the charges of "conspiring to commit murder" and "murder". Both charges typically have facts distinct from each other. A person can be charged with "conspiring to commit murder" even if the murder never actually takes place if all facts necessary to support the charge can be demonstrated through evidence. Further, a person convicted or acquitted of murder can, additionally, be tried on conspiracy as well if it has been determined after the conviction or acquittal that a conspiracy did, in fact, take place.

Mistrials are generally not covered by the double jeopardy clause. If a judge dismisses the case or concludes the trial without deciding the facts in the defendant's favor (for example, by dismissing the case on procedural grounds), the case is a mistrial and may normally be retried.[citation needed] Furthermore, if a jury cannot reach a verdict, the judge may declare a mistrial and order a retrial as was addressed in Perez. When the defendant moves for a mistrial, there is no bar to retrial, even if the prosecutor or judge caused the error that forms the basis of the motion. An exception exists, however, where the prosecutor or judge has acted in bad faith. In Oregon v. Kennedy, the Supreme Court held that "only where the governmental conduct in question is intended to 'goad' the defendant into moving for a mistrial may a defendant raise the bar of double jeopardy to a second trial after having succeeded in aborting the first on his own motion."[25]

The defendant may not be punished twice for the same offense. In certain circumstances, however, a sentence may be increased. It has been held that sentences do not have the same "finality" as acquittals, and may therefore be reviewed by the courts.[citation needed]

The prosecution may not seek capital punishment in the retrial if the jury did not impose it in the original trial. The reason for this exception is that before imposing the death penalty the jury has to make several factual determinations and if the jury does not make these it is seen as the equivalent of an acquittal of a more serious offense.

In Arizona v. Rumsey, a judge had held a separate hearing after the jury trial to decide if the sentence should be death or life imprisonment, in which he decided that the circumstances of the case did not permit death to be imposed. On appeal, the judge's ruling was found to be erroneous. However, even though the decision to impose life instead of death was based on an erroneous interpretation of the law by the judge, the conclusion of life imprisonment in the original case constituted an acquittal of the death penalty and thus death could not be imposed upon a subsequent trial. Even though the acquittal of the death penalty was erroneous in that case, the acquittal must stand.[26]

Double jeopardy also does not apply if the later charge is civil rather than criminal in nature, which involves a different legal standard (crimes must be proven beyond a reasonable doubt, whereas civil wrongs need only be proven by preponderance of evidence or in some matters, clear and convincing evidence). Acquittal in a criminal case does not prevent the defendant from being the defendant in a civil suit relating to the same incident (though res judicata operates within the civil court system). For example, O. J. Simpson was acquitted of a double homicide in a California criminal prosecution, but lost a civil wrongful death claim brought over the same victims.[27]

Defendants happening to be on parole from an earlier offense at the time may also be the subject of a parole violation hearing, which is not considered to be a criminal trial. Since parolees are usually subject to restrictions not imposed on other citizens, evidence of actions that were not deemed to be criminal by the court may be re-considered by the parole board. This legal board could deem the same evidence to be proof of a parole violation. Most states' parole boards have looser rules of evidence than is found in the courts for example, hearsay that had been disallowed in court might be considered by a parole board. Finally, like civil trials parole violation hearings are also subject to a lower standard of proof so it is possible for a parolee to be punished by the parole board for criminal actions that they were acquitted of in court.

In the American military, courts-martial are subject to the same law of double jeopardy, since the Uniform Code of Military Justice has incorporated all of the protections of the U.S. Constitution. The non-criminal proceeding non-judicial punishment (or NJP) is considered to be akin to a civil case and is subject to lower standards than a court-martial, which is the same as a civilian court of law. NJP proceedings are commonly used to correct or punish minor breaches of military discipline. If a NJP proceeding fails to produce conclusive evidence, however, the commanding officer (or ranking official presiding over the NJP) is not allowed to prepare the same charge against the military member in question. In a court-martial, acquittal of the defendant means he is protected permanently from having those charges reinstated.

The most famous American court case invoking the claim of double jeopardy is probably the second murder trial in 1876 of Jack McCall, killer of Wild Bill Hickok. McCall was acquitted in his first trial, which Federal authorities later ruled to be illegal because it took place in an illegal town, Deadwood, then located in South Dakota Indian Territory. At the time, Federal law prohibited all except Native Americans from settling in the Indian Territory. McCall was retried in Federal Indian Territorial court, convicted, and hanged in 1877. He was the first person ever executed by Federal authorities in the Dakota Territory.

Double jeopardy also does not apply if the defendant was never tried from the start. Charges that were dropped or put on hold for any reason can always be reinstated in the futureif not barred by some statute of limitations.

Although the Fifth Amendment initially applied only to the federal government, the U.S. Supreme Court has ruled that the double jeopardy clause applies to the states as well through incorporation by the Fourteenth Amendment.[28]

The double jeopardy clause generally doesn't protect a person from being prosecuted by both a state government and the United States federal government for the same act, nor does it protect a person from being prosecuted by multiple states for the same act. Because United States law considers each of the State governments to be distinct from the federal government of the United States as a whole, with its own laws and court systems, these parallel prosecutions are considered to be different "offenses" under the double jeopardy clause, and the decisions of one government on what to prosecute or not prosecute can't be considered binding on the other. This is known as the "dual sovereignty" or "separate sovereigns" doctrine.

The earliest case at the Supreme Court of the United States to address the matter is Fox v. Ohio in 1847, in which the petitioner, Malinda Fox, was appealing a conviction of a state crime of passing a counterfeit silver dollar. The power to coin money is granted exclusively to Congress, and it was argued that Congress's power precludes the power of any State from prosecuting any crimes pertaining to the money, an argument the Supreme Court rejected in upholding Fox's conviction.[29]

A case that followed on Fox is United States v. Cruikshank, in which the Supreme Court stated that the government of the United States is a separate sovereign from any State:

This does not, however, necessarily imply that the two governments possess powers in common, or bring them into conflict with each other. It is the natural consequence of a citizenship which owes allegiance to two sovereignties, and claims protection from both. The citizen cannot complain, because he has voluntarily submitted himself to such a form of government. He owes allegiance to the two departments, so to speak, and within their respective spheres must pay the penalties which each exacts for disobedience to its laws. In return, he can demand protection from each within its own jurisdiction.[30]

In 1920 the United States was fresh into the Prohibition Era. In one prosecution that occurred in Washington state, a defendant named Lanza was charged under a Washington statute and simultaneously under a United States statute, with the federal indictment stating several facts also stated in the Washington indictment. The Supreme Court addressed the question of the Federal government and a State government having separate prosecutions on the same facts in United States v. Lanza:

We have here two sovereignties, deriving power from different sources, capable of dealing with the same subject matter within the same territory. Each may, without interference by the other, enact laws to secure prohibition, with the limitation that no legislation can give validity to acts prohibited by the amendment. Each government in determining what shall be an offense against its peace and dignity is exercising its own sovereignty, not that of the other.

It follows that an act denounced as a crime by both national and state sovereignties is an offense against the peace and dignity of both and may be punished by each. The Fifth Amendment, like all the other guaranties in the first eight amendments, applies only to proceedings by the federal government (Barron v. City of Baltimore, 7 Pet. 243), and the double jeopardy therein forbidden is a second prosecution under authority of the federal government after a first trial for the same offense under the same authority. (EDITOR'S NOTE: the Barron precedent was superseded 35 years later by the 14th Amendment)[31]

This separation of sovereignty is seen with the separate Federal and State trials of convicted Oklahoma City bombing co-conspirator Terry Nichols. Terry Nichols and Timothy McVeigh were tried and convicted in Federal Court, with Nichols sentenced to life in prison with no possibility of parole, and McVeigh sentenced to death and later executed. While the building was owned by the Federal government, serving as branch locations for multiple Federal agencies, the Federal government had criminal jurisdiction only over 8 of the 168 confirmed deaths. With the express intent of seeing Nichols also sentenced to death, while contemplating the same for McVeigh if his death sentence was overturned on appeal, the State of Oklahoma filed charges against Terry Nichols.[32]

There may also be Federal laws that call other facts into question beyond the scope of any State law. A state may try a defendant for murder, after which the Federal government might try the same defendant for a Federal crime (perhaps a civil rights violation or a kidnapping) connected to the same act. The officers of the Los Angeles Police Department who were charged with assaulting Rodney King in 1991 were acquitted by a jury of the Superior Courts of California, but some were later convicted and sentenced in Federal court for violating King's civil rights. Similar legal processes were used for prosecuting racially motivated crimes in the Southern United States in the 1960s during the time of the Civil Rights Movement, when those crimes had not been actively prosecuted, or had resulted in acquittals by juries that were thought to be racist or overly sympathetic with the accused in local courts.

Federal jurisdiction may apply because the defendant is a member of the armed forces or the victim(s) are armed forces members or dependents. U.S. Army Master Sergeant Timothy B. Hennis was acquitted on retrial in North Carolina for the 1985 murders of Kathryn Eastburn (31 y.o.) and her daughters, Kara (5 y.o.) and Erin (3 y.o.), stabbed to death in their home near Fort Bragg, North Carolina.[33] Two decades later, Hennis was recalled to active duty, court-martialed by the Army for the crime, convicted, and sentenced again to death.[34] Richard Dieter, executive director of the Death Penalty Information Center, observed of this case, "Certainly, no one [in the US] has been exonerated and then returned to death row for the same crime except Hennis."[35] Hennis challenged jurisdiction under the Double Jeopardy Clause on appeal to the United States Army Court of Criminal Appeals, which rejected the challenge.[36]

Furthermore, as ruled in Heath v. Alabama, the "separate sovereigns" rule allows two states to prosecute for the same criminal act.[37] For example, if a man stood in New York and shot and killed a man standing over the border in Connecticut, both New York and Connecticut could charge the shooter with murder.[38]

In order for a state to have jurisdiction to prosecute a criminal act, either the action directly resulting in consequences such as death or injury must occur while the perpetrator is in the state and/or the consequences must occur in the state. For example, if a man piloting an airplane took off from New York, flew to Connecticut and while flying over Connecticut committed a murder by dropping something from the aircraft, the only two sovereigns able to prosecute would be Connecticut and the federal government (due to the murder taking place from an aircraft) - New York would lack jurisdiction since no criminal act would have been perpetrated from there. But if the same man while still in New York remotely piloted a drone using the cellular network and used that vehicle to commit the murder in Connecticut, then three separate sovereigns could prosecute the murder (New York, Connecticut and the federal government due to the use of the unmanned aircraft as well as interstate telecommunications).

Only the states and tribal jurisdictions[39] are recognized as possessing a separate sovereignty, whereas territories of the United States,[40] the military and naval forces, and the capital city of Washington, D.C., are exclusively under Federal sovereignty. Acquittal in the court system of any of these entities would therefore preclude a re-trial (or a court-martial) in any court system under Federal jurisdiction.

The dual sovereignty nature of the Double Jeopardy Clause was reheard as part of Gamble v. United States, decided in June 2019. The Supreme Court upheld the nature of dual sovereignty between federal and state charges in a 72 decision.[41][42]

Though the Supreme Court of the United States has recognized the dual sovereignty doctrine as an exception to double jeopardy, the United States will not exercise its dual sovereignty power on everyone who becomes subject to it. As a self-imposed limitation on its dual sovereignty power, the United States Department of Justice has a policy called the Petite policy, named after Petite v. United States.[43] The formal name of the policy is "Dual and Successive Prosecution Policy"[44] and it "establishes guidelines for the exercise of discretion by appropriate officers of the Department of Justice in determining whether to bring a federal prosecution based on substantially the same act(s) or transactions involved in a prior state or federal proceeding."

Under this policy, the Department of Justice presumes that any prosecution at the State level for any fact applicable to any Federal charge vindicates any Federal interest in those facts, even if the outcome is an acquittal. As an example, a person who commits murder within the jurisdiction of a State is subject to that State's murder statute and the United States murder statute (18U.S.C.1111). The Federal government will defer to the State to prosecute under their statute. Whatever the outcome of the trial, acquittal or conviction, the Department of Justice will presume that prosecution to vindicate any Federal interest and will not initiate prosecution under the United States Code.

However that presumption can be overcome. The policy stipulates five criteria that may overcome that presumption (particularly for an acquittal at the State level):

The presumption may be overcome even when a conviction was achieved in the prior prosecution in the following circumstances:

The presumption also may be overcome, irrespective of the result in a prior state prosecution, in those rare cases where the following three conditions are met:

The existence of any of these criteria is to be determined by an Assistant Attorney General of the United States. If a prosecution is determined to have proceeded without authorization, the Federal government may and has requested the Court vacate an indictment. Such a move is in line with the Courts vacating indictments wherein prosecutions were discovered to have violated Department of Justice policy. Indictments have also been vacated when the Federal government first represents to the Court the prosecution was authorized but later determines that authorization to have been mistaken.[45]

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Double Jeopardy Clause - Wikipedia

CBIC notifies Central Goods And Services Tax (Fifth Amendment) Rules, 2022 In Accordance With 48th GST… – Live Law – Indian Legal News

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CBIC notifies Central Goods And Services Tax (Fifth Amendment) Rules, 2022 In Accordance With 48th GST... - Live Law - Indian Legal News

THERALINK TECHNOLOGIES, INC. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS (form 10-K) – Marketscreener.com

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Colonization of Mars – Wikipedia

Proposed concepts for human settlements on Mars

Colonization or settlement of Mars is the theoretical human migration and long-term human establishment of Mars. The prospect has garnered interest from public space agencies and private corporations and has been extensively explored in science fiction writing, film, and art.

Organizations have proposed plans for a human mission to Mars, the first step towards any colonization effort, but no person has set foot on the planet, and there have been no return missions. However, landers and rovers have successfully explored the planetary surface and delivered information about conditions on the ground.

Mars' orbit is close to Earth's orbit and the asteroid belt. While Mars' day and general composition are similar to Earth, the planet is hostile to life. Mars has an unbreathable atmosphere, thin enough that its temperature on average fluctuates between 70 and 0C (94 and 32F), yet thick enough to cause planet-wide dust storms. The barren landscape on Mars is covered by fine dust and intense ionizing radiation. Mars has in-situ resources, such as underground water, Martian soil, and ore, which could be leveraged by colonists. Opportunities to generate electricity via wind, solar, and nuclear power using resources on Mars are poor.

Justifications and motivations for colonizing Mars include curiosity, the potential for humans to provide more in-depth observational research than uncrewed rovers, an economic interest in its resources, and the possibility that the settlement of other planets could decrease the likelihood of human extinction. Difficulties and hazards include radiation exposure during a trip to Mars and on its surface, toxic soil, low gravity, the isolation that accompanies Mars' distance from Earth, a lack of water, and cold temperatures.

Commitments to researching permanent settlement have been made by public space agenciesNASA, ESA, Roscosmos, ISRO, the CNSA, among othersand private organizationsSpaceX, Lockheed Martin, and Boeing.

Since the 20th century, there have been several proposed human missions to Mars both by government agencies and private companies.[vague]

Most of the human mission concepts as currently conceived by national governmental space programs would not be direct precursors to colonization. Programs such as those being tentatively planned by NASA, Roscosmos, and ESA are intended solely as exploration missions, with the establishment of a permanent base possible but not yet the main goal.[citation needed]

Colonization requires the establishment of permanent habitats that have the potential for self-expansion and self-sustenance. Two early proposals for building habitats on Mars are the Mars Direct and the Semi-Direct concepts, advocated by Robert Zubrin, an advocate of the colonization of Mars.[1]

At the February 2017 World Government Summit, the United Arab Emirates announced a plan to establish a settlement on Mars by 2117, led by the Mohammed bin Rashid Space Centre.[2][3]

SpaceX has proposed the development of Mars transportation infrastructure in order to facilitate the eventual colonization of Mars. The mission architecture includes fully reusable launch vehicles, human-rated spacecraft, on-orbit propellant tankers, rapid-turnaround launch/landing mounts, and local production of rocket fuel on Mars via in situ resource utilization (ISRU). SpaceX's aspirational goal as of 2017[update] was to land their cargo Starships on Mars by 2024 and the first 2 crewed starships by 2026.[4][5][needs update]

The surface gravity of Mars is just 38% that of Earth. Although microgravity is known to cause health problems such as muscle loss and bone demineralization,[7][8] it is not known if Martian gravity would have a similar effect. The Mars Gravity Biosatellite was a proposed project designed to learn more about what effect Mars' lower surface gravity would have on humans, but it was cancelled due to a lack of funding.[9]

Mars has a surface area that is 28.4% of Earth's, which is only slightly less than the amount of dry land on Earth (which is 29.2% of Earth's surface). Mars has half the radius of Earth and only one-tenth the mass. This means that it has a smaller volume (15%) and lower average density than Earth.

Due to the lack of a magnetosphere, solar particle events and cosmic rays can easily reach the Martian surface.[10][11][12]

Atmospheric pressure on Mars is far below the Armstrong limit at which people can survive without pressure suits. Since terraforming cannot be expected as a near-term solution, habitable structures on Mars would need to be constructed with pressure vessels similar to spacecraft, capable of containing a pressure between 30 and 100kPa. The atmosphere is also toxic as most of it consists of carbon dioxide (95%carbon dioxide, 3%nitrogen, 1.6%argon, and traces totaling less than 0.4% of other gases, including oxygen).

This thin atmosphere does not filter out ultraviolet sunlight, which causes instability in the molecular bonds between atoms. For example, ammonia (NH3) is not stable in the Martian atmosphere and breaks down after a few hours.[13]Also due to the thinness of the atmosphere, the temperature difference between day and night is much larger than on Earth, typically around 70C (125F).[14] However, the day/night temperature variation is much lower during dust storms when very little light gets through to the surface even during the day, and instead warms the middle atmosphere.[15]

Water on Mars is scarce, with rovers Spirit and Opportunity finding less than there is in Earth's driest desert.[16][17][18]

The climate is much colder than Earth, with mean surface temperatures between 186 and 268K (87 and 5C; 125 and 23F) (depending on the season and latitude).[19][20] The lowest temperature ever recorded on Earth was 184 K (89.2C, 128.6F) in Antarctica.

Because Mars is about 52% farther from the Sun, the amount of solar energy entering its upper atmosphere per unit area (the solar constant) is only around 43.3% of what reaches the Earth's upper atmosphere.[21] However, due to the much thinner atmosphere, a higher fraction of the solar energy reaches the surface as radiation.[22][23] The maximum solar irradiance on Mars is about 590 W/m2 compared to about 1000 W/m2 at the Earth's surface; optimal conditions on the Martian equator can be compared to those on Devon Island in the Canadian Arctic in June.[24] Mars' orbit is more eccentric than Earth's, increasing temperature and solar constant variations over the course of the Martian year.[citation needed] Mars has no rain and virtually no clouds,[citation needed] so although cold, it is permanently sunny (apart from during dust storms). This means solar panels can always operate at maximum efficiency on dust-free days.

Global dust storms are common throughout the year and can cover the entire planet for weeks, blocking sunlight from reaching the surface.[25][26] This has been observed to cause temperature drops of 4C (7F) for several months after the storm.[27] In contrast, the only comparable events on Earth are infrequent large volcanic eruptions such as the Krakatoa event which threw large amounts of ash into the atmosphere in 1883, causing a global temperature drop of around 1C (2F).These dust storms would affect electricity production from solar panels for long periods, and interfere with communications with Earth.[15]

Mars has an axial tilt of 25.19, similar to Earth's 23.44. As a result, Mars has seasons much like Earth, though on average they last nearly twice as long because the Martian year is about 1.88Earth years. Mars' temperature regime is more similar to Earth's than all other planets in the solar system. While generally colder than Earth, Mars can have Earth-like temperatures in some areas and at certain times.

The Martian soil is toxic due to relatively high concentrations of chlorine and associated compounds, such as perchlorates, which are hazardous to all known forms of life,[28][29] even though some halotolerant microorganisms might be able to cope with enhanced perchlorate concentrations by drawing on physiological adaptations similar to those observed in the yeast Debaryomyces hansenii exposed in lab experiments to increasing NaClO4 concentrations.[30]

Plants and animals cannot survive the ambient conditions on the surface of Mars.[31] However, some extremophile organisms that survive in hostile conditions on Earth have endured periods of exposure to environments that approximate some of the conditions found on Mars.

The Martian day (or sol) is very close in duration to Earth's. A solar day on Mars is 24 hours, 39 minutes and 35.244 seconds.[32]

Conditions on the surface of Mars are closer to the conditions on Earth in terms of temperature and sunlight than on any other planet or moon, except for the cloud tops of Venus.[33] However, the surface is not hospitable to humans or most known life forms due to the radiation, greatly reduced air pressure, and an atmosphere with only 0.16%oxygen.

In 2012, it was reported that some lichen and cyanobacteria survived and showed remarkable adaptation capacity for photosynthesis after 34days in simulated Martian conditions in the Mars Simulation Laboratory (MSL) maintained by the German Aerospace Center (DLR).[34][35][36] Some scientists think that cyanobacteria could play a role in the development of self-sustainable crewed outposts on Mars.[37] They propose that cyanobacteria could be used directly for various applications, including the production of food, fuel and oxygen, but also indirectly: products from their culture could support the growth of other organisms, opening the way to a wide range of life-support biological processes based on Martian resources.[37]

Humans have explored parts of Earth that match some conditions on Mars. Based on NASA rover data, temperatures on Mars (at low latitudes) are similar to those in Antarctica.[38] The atmospheric pressure at the highest altitudes reached by piloted balloon ascents (35km (114,000 feet) in 1961,[39] 38km in 2012) is similar to that on the surface of Mars. However, the pilots were not exposed to the extremely low pressure, as it would have killed them, but seated in a pressurized capsule.[40]

Human survival on Mars would require living in artificial Mars habitats with complex life-support systems. One key aspect of this would be water processing systems. Being made mainly of water, a human being would die in a matter of days without it. Even a 58% decrease in total body water causes fatigue and dizziness and a 10% decrease physical and mental impairment (See Dehydration). A person in the UK uses 70140litres of water per day on average.[41] Through experience and training, astronauts on the ISS have shown it is possible to use far less, and that around 70% of what is used can be recycled using the ISS water recovery systems. (For instance, half of all water is used during showers.[42]) Similar systems would be needed on Mars but would need to be much more efficient, since regular robotic deliveries of water to Mars would be prohibitively expensive (the ISS is supplied with water four times per year). Potential access to on-site water (frozen or otherwise) via drilling has been investigated by NASA.[43]

Mars presents a hostile environment for human habitation. Different technologies have been developed to assist long-term space exploration and may be adapted for habitation on Mars. The existing record for the longest consecutive space flight is 438days by cosmonaut Valeri Polyakov,[44] and the most accrued time in space is 878days by Gennady Padalka.[45] The longest time spent outside the protection of the Earth's Van Allen radiation belt is about 12days for the Apollo 17 moon landing. This is minor in comparison to the 1100-day journey to Mars and back[46] envisioned by NASA for possibly as early as the year 2028. Scientists have also hypothesized that many different biological functions can be negatively affected by the environment of Mars colonies. Due to higher levels of radiation, there are a multitude of physical side-effects that must be mitigated.[47] In addition, Martian soil contains high levels of toxins which are hazardous to human health.

The difference in gravity may negatively affect human health by weakening bones and muscles. There is also risk of osteoporosis and cardiovascular problems. Current rotations on the International Space Station put astronauts in zero gravity for six months, a comparable length of time to a one-way trip to Mars. This gives researchers the ability to better understand the physical state that astronauts going to Mars would arrive in. Once on Mars, surface gravity is only 38% of that on Earth. Microgravity affects the cardiovascular, musculoskeletal and neurovestibular (central nervous) systems. The cardiovascular effects are complex. On Earth, blood within the body stays 70% below the heart, but in microgravity this is not the case due to nothing pulling the blood down. This can have several negative effects. Once entering into microgravity, the blood pressure in the lower body and legs is significantly reduced.[48] This causes legs to become weak through loss of muscle and bone mass. Astronauts show signs of a puffy face and chicken legs syndrome. After the first day of reentry back to earth, blood samples showed a 17% loss of blood plasma, which contributed to a decline of erythropoietin secretion.[49][50] On the skeletal system which is important to support our body's posture, long space flight and exposure to microgravity cause demineralization and atrophy of muscles. During re-acclimation, astronauts were observed to have a myriad of symptoms including cold sweats, nausea, vomiting and motion sickness.[51] Returning astronauts also felt disoriented. Journeys to and from Mars being six months is the average time spent at the ISS. Once on Mars with its lesser surface gravity (38% percent of Earth's), these health effects would be a serious concern.[52] Upon return to Earth, recovery from bone loss and atrophy is a long process and the effects of microgravity may never fully reverse.[citation needed]

Dangerous amounts of radiation reach Mars' surface despite it being much further from the Sun compared to Earth. Mars has lost its inner dynamo giving it a weaker global magnetosphere than Earth does. Combined with a thin atmosphere, this permits a significant amount of ionizing radiation to reach the Martian surface. There are two main types of radiation risks to traveling outside the protection of Earth's atmosphere and magnetosphere: galactic cosmic rays (GCR) and solar energetic particles (SEP). Earth's magnetosphere protects from charged particles from the Sun, and the atmosphere protects against uncharged and highly energetic GCRs. There are ways to mitigate solar radiation, but without much of an atmosphere, the only solution to the GCR flux is heavy shielding amounting to roughly 15 centimeters of steel, 1 meter of rock, or 3 meters of water, limiting human colonists to living underground most of the time.[53]

The Mars Odyssey spacecraft carries an instrument, the Mars Radiation Environment Experiment (MARIE), to measure the radiation. MARIE found that radiation levels in orbit above Mars are 2.5 times higher than at the International Space Station. The average daily dose was about 220Gy (22mrad)equivalent to 0.08Gy per year.[54] A three-year exposure to such levels would exceed the safety limits currently adopted by NASA,[55] and the risk of developing cancer due to radiation exposure after a Mars mission could be two times greater than what scientists previously thought.[56][57] Occasional solar proton events (SPEs) produce much higher doses, as observed in September 2017, when NASA reported radiation levels on the surface of Mars were temporarily doubled, and were associated with an aurora 25-times brighter than any observed earlier, due to a massive, and unexpected, solar storm.[58] Building living quarters underground (possibly in Martian lava tubes) would significantly lower the colonists' exposure to radiation.

Much remains to be learned about space radiation. In 2003, NASA's Lyndon B. Johnson Space Center opened a facility, the NASA Space Radiation Laboratory, at Brookhaven National Laboratory, that employs particle accelerators to simulate space radiation. The facility studies its effects on living organisms, as well as experimenting with shielding techniques.[62] Initially, there was some evidence that this kind of low level, chronic radiation is not quite as dangerous as once thought; and that radiation hormesis occurs.[63] However, results from a 2006 study indicated that protons from cosmic radiation may cause twice as much serious damage to DNA as previously estimated, exposing astronauts to greater risk of cancer and other diseases.[64] As a result of the higher radiation in the Martian environment, the summary report of the Review of U.S. Human Space Flight Plans Committee released in 2009 reported that "Mars is not an easy place to visit with existing technology and without a substantial investment of resources."[64] NASA is exploring a variety of alternative techniques and technologies such as deflector shields of plasma to protect astronauts and spacecraft from radiation.[64]

Due to the communication delays, new protocols need to be developed in order to assess crew members' psychological health. Researchers have developed a Martian simulation called HI-SEAS (Hawaii Space Exploration Analog and Simulation) that places scientists in a simulated Martian laboratory to study the psychological effects of isolation, repetitive tasks, and living in close-quarters with other scientists for up to a year at a time. Computer programs are being developed to assist crews with personal and interpersonal issues in absence of direct communication with professionals on Earth.[65] Current suggestions for Mars exploration and colonization are to select individuals who have passed psychological screenings. Psychosocial sessions for the return home are also suggested in order to reorient people to society.

Various works of fiction put forward the idea of terraforming Mars to allow a wide variety of life forms, including humans, to survive unaided on Mars' surface. Some ideas of possible technologies that may be able to contribute to the terraforming of Mars have been conjectured, but none would be able to bring the entire planet into the Earth-like habitat pictured in science fiction.[66]

To be self-sustaining, a colony would have to be large enough to provide all the necessary living services. These include[67]

As the number of individuals grows, both activities and objects can be shared between them. Growth also will offset the risks of collapse of the society, caused by sudden deaths, accidents, infertility or inbreeding. But this may not prevent mortal combat between different groups of individuals, or the loss of efficiency due to inappropriate social organization.

By mathematical modelling of the time spent by people on these issues and by keeping things simple, Salotti concludes that the minimum number for a colony on Mars is 110.[67] This is close to other studies of the genetic problems involved in the longer journey to Proxima Centauri b (6,000+ years).[68]

Mars requires less energy per unit mass (delta V) to reach from Earth than any planet except Venus. Using a Hohmann transfer orbit, a trip to Mars requires approximately nine months in space.[69] Modified transfer trajectories that cut the travel time down to four to seven months in space are possible with incrementally higher amounts of energy and fuel compared to a Hohmann transfer orbit, and are in standard use for robotic Mars missions. Shortening the travel time below about six months requires higher delta-v and an increasing amount of fuel, and is difficult with chemical rockets. It could be feasible with advanced spacecraft propulsion technologies, some of which have already been tested to varying levels, such as Variable Specific Impulse Magnetoplasma Rocket,[70] and nuclear rockets. In the former case, a trip time of forty days could be attainable,[71] and in the latter, a trip time down to about two weeks.[1] In 2016, a University of California, Santa Barbara scientist said they could further reduce travel time for a small robotic probe to Mars down to "as little as 72 hours" with the use of a laser propelled sail (directed photonic propulsion) system instead of the fuel-based rocket propulsion system.[72][73]

During the journey the astronauts would be subject to radiation, which would require a means to protect them. Cosmic radiation and solar wind cause DNA damage, which increases the risk of cancer significantly. The effect of long-term travel in interplanetary space is unknown, but scientists estimate an added risk of between 1% and 19% (one estimate is 3.4%) for males to die of cancer because of the radiation during the journey to Mars and back to Earth. For females the probability is higher due to generally larger glandular tissues.[74]

Mars has a surface gravity 0.38 times that of Earth, and the density of its atmosphere is about 0.6% of that on Earth.[75] The relatively strong gravity and the presence of aerodynamic effects make it difficult to land heavy, crewed spacecraft with thrusters only, as was done with the Apollo Moon landings, yet the atmosphere is too thin for aerodynamic effects to be of much help in aerobraking and landing a large vehicle. Landing piloted missions on Mars would require braking and landing systems different from anything used to land crewed spacecraft on the Moon or robotic missions on Mars.[76]

If one assumes carbon nanotube construction material will be available with a strength of 130GPa (19,000,000psi) then a space elevator could be built to land people and material on Mars.[77]A space elevator on Phobos (a Martian moon) has also been proposed.[78]

Phobos is synchronously orbiting Mars, where the same face stays facing the planet at ~6,028 km above the Martian surface. A space elevator could extend down from Phobos to Mars 6,000 km, about 28 kilometers from the surface, and just out of the atmosphere of Mars. A similar space elevator cable could extend out 6,000 km the opposite direction that would counterbalance Phobos. In total the space elevator would extend out over 12,000 km which would be below Areostationary orbit of Mars (17,032 km). A rocket launch would still be needed to get the rocket and cargo to the beginning of the space elevator 28 km above the surface. The surface of Mars is rotating at 0.25 km/s at the equator and the bottom of the space elevator would be rotating around Mars at 0.77 km/s, so only 0.52 km/s of Delta-v would be needed to get to the space elevator. Phobos orbits at 2.15 km/s and the outer most part of the space elevator would rotate around Mars at 3.52 km/s.[79]

Colonization of Mars would require a wide variety of equipmentboth equipment to directly provide services to humans and production equipment used to produce food, propellant, water, energy and breathable oxygenin order to support human colonization efforts. Required equipment will include:[1]

In order to function at all the colony would need the basic utilities to support human civilization. These would need to be designed to handle the harsh Martian environment and would either have to be serviceable while wearing an EVA suit or housed inside a human habitable environment. For example, if electricity generation systems rely on solar power, large energy storage facilities will also be needed to cover the periods when dust storms block out the sun, and automatic dust removal systems may be needed to avoid human exposure to conditions on the surface.[27] If the colony is to scale beyond a few people, systems will also need to maximise use of local resources to reduce the need for resupply from Earth, for example by recycling water and oxygen and being adapted to be able to use any water found on Mars, whatever form it is in.

Communications with Earth are relatively straightforward during the half-sol when Earth is above the Martian horizon. NASA and ESA included communications relay equipment in several of the Mars orbiters, so Mars already has communications satellites. While these will eventually wear out, additional orbiters with communication relay capability are likely to be launched before any colonization expeditions are mounted.

The one-way communication delay due to the speed of light ranges from about 3 minutes at closest approach (approximated by perihelion of Mars minus aphelion of Earth) to 22minutes at the largest possible superior conjunction (approximated by aphelion of Mars plus aphelion of Earth). Real-time communication, such as telephone conversations or Internet Relay Chat, between Earth and Mars would be highly impractical due to the long time lags involved. NASA has found that direct communication can be blocked for about two weeks every synodic period, around the time of superior conjunction when the Sun is directly between Mars and Earth,[82] although the actual duration of the communications blackout varies from mission to mission depending on various factorssuch as the amount of link margin designed into the communications system, and the minimum data rate that is acceptable from a mission standpoint. In reality most missions at Mars have had communications blackout periods of the order of a month.[83]

A satellite at the L4 or L5 EarthSun Lagrangian point could serve as a relay during this period to solve the problem; even a constellation of communications satellites would be a minor expense in the context of a full colonization program. However, the size and power of the equipment needed for these distances make the L4 and L5 locations unrealistic for relay stations, and the inherent stability of these regions, although beneficial in terms of station-keeping, also attracts dust and asteroids, which could pose a risk.[84] Despite that concern, the STEREO probes passed through the L4 and L5 regions without damage in late 2009.

Recent work by the University of Strathclyde's Advanced Space Concepts Laboratory, in collaboration with the European Space Agency, has suggested an alternative relay architecture based on highly non-Keplerian orbits. These are a special kind of orbit produced when continuous low-thrust propulsion, such as that produced from an ion engine or solar sail, modifies the natural trajectory of a spacecraft. Such an orbit would enable continuous communications during solar conjunction by allowing a relay spacecraft to "hover" above Mars, out of the orbital plane of the two planets.[85] Such a relay avoids the problems of satellites stationed at either L4 or L5 by being significantly closer to the surface of Mars while still maintaining continuous communication between the two planets.

The path to a human colony could be prepared by robotic systems such as the Mars Exploration Rovers Spirit, Opportunity, Curiosity and Perseverance. These systems could help locate resources, such as ground water or ice, that would help a colony grow and thrive. The lifetimes of these systems would be years and even decades, and as recent developments in commercial spaceflight have shown, it may be that these systems will involve private as well as government ownership. These robotic systems also have a reduced cost compared with early crewed operations, and have less political risk.

Wired systems might lay the groundwork for early crewed landings and bases, by producing various consumables including fuel, oxidizers, water, and construction materials. Establishing power, communications, shelter, heating, and manufacturing basics can begin with robotic systems, if only as a prelude to crewed operations.

Mars Surveyor 2001 Lander MIP (Mars ISPP Precursor) was to demonstrate manufacture of oxygen from the atmosphere of Mars,[86] and test solar cell technologies and methods of mitigating the effect of Martian dust on the power systems.[87][needs update]

Before any people are transported to Mars on the notional 2020s Mars transportation infrastructure envisioned by SpaceX, a number of robotic cargo missions would be undertaken first in order to transport the requisite equipment, habitats and supplies.[88]Equipment that would be necessary would include "machines to produce fertilizer, methane and oxygen from Mars' atmospheric nitrogen and carbon dioxide and the planet's subsurface water ice" as well as construction materials to build transparent domes for initial agricultural areas.[89]

As with early colonies in the New World, economics would be a crucial aspect to a colony's success. The reduced gravity well of Mars and its position in the Solar System may facilitate MarsEarth trade and may provide an economic rationale for continued settlement of the planet. Given its size and resources, this might eventually be a place to grow food and produce equipment to mine the asteroid belt.

Some early Mars colonies might specialize in developing local resources for Martian consumption, such as water and/or ice. Local resources can also be used in infrastructure construction.[90] One source of Martian ore currently known to be available is metallic iron in the form of nickeliron meteorites. Iron in this form is more easily extracted than from the iron oxides that cover the planet.

Another main inter-Martian trade good during early colonization could be manure.[91] Assuming that life doesn't exist on Mars, the soil is going to be very poor for growing plants, so manure and other fertilizers will be valued highly in any Martian civilization until the planet changes enough chemically to support growing vegetation on its own.

Solar power is a candidate for power for a Martian colony. Solar insolation (the amount of solar radiation that reaches Mars) is about 42% of that on Earth, since Mars is about 52% farther from the Sun and insolation falls off as the square of distance. But the thin atmosphere would allow almost all of that energy to reach the surface as compared to Earth, where the atmosphere absorbs roughly a quarter of the solar radiation. Sunlight on the surface of Mars would be much like a moderately cloudy day on Earth.[92]

Space colonization on Mars can roughly be said to be possible when the necessary methods of space colonization become cheap enough (such as space access by cheaper launch systems) to meet the cumulative funds that have been gathered for the purpose.

Although there are no immediate prospects for the large amounts of money required for any space colonization to be available given traditional launch costs,[93][full citation needed] there is some prospect of a radical reduction to launch costs in the 2020s, which would consequently lessen the cost of any efforts in that direction. With a published price of US$62 million per launch of up to 22,800kg (50,300lb) payload to low Earth orbit or 4,020kg (8,860lb) to Mars,[94] SpaceX Falcon 9 rockets are already the "cheapest in the industry".[95] SpaceX's reusable plans include Falcon Heavy and future methane-based launch vehicles including the Starship. If SpaceX is successful in developing the reusable technology, it would be expected to "have a major impact on the cost of access to space", and change the increasingly competitive market in space launch services.[96]

Alternative funding approaches might include the creation of inducement prizes. For example, the 2004 President's Commission on Implementation of United States Space Exploration Policy suggested that an inducement prize contest should be established, perhaps by government, for the achievement of space colonization. One example provided was offering a prize to the first organization to place humans on the Moon and sustain them for a fixed period before they return to Earth.[97]

Since Mars is much closer to the asteroid belt than Earth is, it would take less Delta-v to get to the Asteroid belt and return minerals to Mars. One hypothesis is that the origin of the Moons of Mars (Phobos and Deimos) are actually Asteroid captures from the Asteroid belt.[98] 16 Psyche in the main belt could have over $10,000 Quadrillion Dollars worth of minerals. NASA is planning a mission for October 10, 2023 for the Psyche orbiter to launch and get to the asteroid by August 2029 to study.[99] 511 Davida could have $27 quadrillion Dollars worth of minerals and resources.[100] Using the moon Phobos to launch spacecraft is energetically favorable and a useful location from which to dispatch missions to main belt asteroids.[101] Mining the asteroid belt from Mars and its moons could help in the colonization of Mars.[102][103][104]

Caves would naturally provide a degree of insulation from Martian hazards for humans on the planet.[105] These hazards include radiation, impactor events, and the wide range in temperatures on the surface.[105]

Mars Odyssey found what appear to be natural caves near the volcano Arsia Mons. It has been speculated that settlers could benefit from the shelter that these or similar structures could provide from radiation and micrometeoroids. Geothermal energy is also suspected in the equatorial regions.[106]

A team of researchers which presented at Geological Society of America Connects 2022 identified some 139 caves worth exploring as potential shelters.[105] Each was within 60 miles of a location ideal for use as a landing site and had been imaged in high-resolution by HiRISE.[105]

Several possible Martian lava tube skylights have been located on the flanks of Arsia Mons. Earth based examples indicate that some should have lengthy passages offering complete protection from radiation and be relatively easy to seal using on-site materials, especially in small subsections.[107]

Hellas Planitia is the lowest lying plain below the Martian geodetic datum. The atmospheric pressure is relatively higher in this place when compared to the rest of Mars.

Robotic spacecraft to Mars are required to be sterilized, to have at most 300,000 spores on the exterior of the craftand more thoroughly sterilized if they contact "special regions" containing water,[108][109] otherwise there is a risk of contaminating not only the life-detection experiments but possibly the planet itself.

It is impossible to sterilize human missions to this level, as humans are host to typically a hundred trillion microorganisms of thousands of species of the human microbiome, and these cannot be removed while preserving the life of the human. Containment seems the only option, but it is a major challenge in the event of a hard landing (i.e. crash).[110] There have been several planetary workshops on this issue, but with no final guidelines for a way forward yet.[111] Human explorers would also be vulnerable to back contamination to Earth if they become carriers of microorganisms should Mars have life.[112]

It is unforeseen how the first human landing on Mars will change the current policies regarding the exploration of space and occupancy of celestial bodies. In the 1967 United Nations Outer Space Treaty, it was determined that no country may take claim to space or its inhabitants. Since the planet Mars offers a challenging environment and dangerous obstacles for humans to overcome, the laws and culture on the planet will most likely be very different from those on Earth.[113] With Elon Musk announcing his plans for travel to Mars, it is uncertain how the dynamic of a private company possibly being the first to put a human on Mars will play out on a national and global scale.[114][115] NASA had to deal with several cuts in funding. During the presidency of Barack Obama, the objective for NASA to reach Mars was pushed to the background.[116] In 2017, president Donald Trump promised to return humans to the Moon and eventually Mars,[117] effectively taking action by increasing NASA budget with $1.1 billion,[118] and mostly focus on the development of the new Space Launch System.[119][120]

Space colonization in general has been discussed as continuation of imperialism and colonialism,[121] especially regarding Mars colonial decision making and reasons for colonial labor[122] and land exploitation have been questioned with postcolonial critique. Seeing the need for inclusive[123] and democratic participation and implementation of any space and Mars exploration, infrastructure, or colonialization, many have called for dramatic sociological reforms and guarantees to prevent racism, sexism, and other forms of prejudice.[124]

The narrative of space exploration as a "New Frontier" has been criticized as unreflected continuation of settler colonialism and manifest destiny, continuing the narrative of colonial exploration as fundamental to the assumed human nature.[125][126][127]

The predominant perspective of territorial colonization in space has been called surfacism, especially comparing advocacy for colonization of Mars opposed to Venus.[128][129]

One possible ethical challenge that space travelers might face is that of pregnancy during the trip. According to NASA's policies, it is forbidden for members of the crew to engage in sex in space. NASA wants its crew members to treat each other like coworkers would in a professional environment. A pregnant member on a spacecraft is dangerous to all those aboard. The pregnant woman and child would need additional nutrition from the rations aboard, as well as special treatment and care. The pregnancy would impinge on the pregnant crew member's duties and abilities. It is still not fully known how the environment in a spacecraft would affect the development of a child aboard. It is known however that a fetus would be more susceptible to solar radiation in space, which would likely have a negative effect on its cells and genetics.[131] During a long trip to Mars, it is likely that members of craft may engage in sex due to their stressful and isolated environment.[132]

Mars colonization is advocated by several non-governmental groups for a range of reasons and with varied proposals. One of the oldest groups is the Mars Society who promote a NASA program to accomplish human exploration of Mars and have set up Mars analog research stations in Canada and the United States. Mars to Stay advocates recycling emergency return vehicles into permanent settlements as soon as initial explorers determine permanent habitation is possible.

Elon Musk founded SpaceX with the long-term goal of developing the technologies that will enable a self-sustaining human colony on Mars.[114][133] Richard Branson, in his lifetime, is "determined to be a part of starting a population on Mars. I think it is absolutely realistic. It will happen... I think over the next 20 years," [from 2012] "we will take literally hundreds of thousands of people to space and that will give us the financial resources to do even bigger things".[134]

Author Robert Zubrin has been a major advocate for Mars exploration and colonization for many years. He is a member of the Mars society and has authored several fiction and nonfiction books about the subject. In 1996 he wrote The Case for Mars: The Plan to Settle the Red Planet and Why We Must. He continues to advocate for Mars and space exploration with his most recent book being The Case for Space: How the Revolution in Spaceflight Opens Up a Future of Limitless Possibility.

In June 2013, Buzz Aldrin, American engineer and former astronaut, and the second person to walk on the Moon, wrote an opinion, published in The New York Times, supporting a human mission to Mars and viewing the Moon "not as a destination but more a point of departure, one that places humankind on a trajectory to homestead Mars and become a two-planet species".[135] In August 2015, Aldrin, in association with the Florida Institute of Technology, presented a "master plan", for NASA consideration, for astronauts, with a "tour of duty of ten years", to colonize Mars before the year 2040.[136]

A few instances in fiction provide detailed descriptions of Mars colonization. They include:

See the rest here:

Colonization of Mars - Wikipedia

Mars One – Wikipedia

This article is about the defunct Mars colonization firm. For the first Soviet spacecraft for Mars, see Mars 1. For other uses, see Mars 1 (disambiguation).

Defunct organization and company that promoted Mars colonization

Mars One was a small private Dutch organization that received money from investors by claiming it would use it to land the first humans on Mars and leave them there to establish a permanent human colony.[1][2][3] From its announcement in 2012 to its bankruptcy in early 2019, it is estimated to have received tens of millions of dollars.[4] The organization was not an aerospace company and did not manufacture hardware.[5]

Mars One consisted of two entities: the not-for-profit Mars One Foundation, and the for-profit company Mars One Ventures which was the controlling stockholder of the for-profit Interplanetary Media Group that also managed the broadcasting rights. The Mars One Foundation, based in the Netherlands, managed the project. The small organization had four employees,[6] and intended to make profits by selling media (documentaries) about the personnel selection, training and colonization.[7] The first mission was estimated by its CEO Bas Lansdorp to cost about $6 billion as of the 2010s.[7][8]

The concept had been criticized by scientists, engineers, and those in the aerospace industry as glossing over logistics and medical concerns, and lacking critical concepts about hardware. The concept had been called a suicide mission by academia, the spaceflight industry, and international news.[6] On 15 January 2019, a court decision was settled to liquidate the for-profit company, bankrupting it in the process.[9][10]

Mars One's original concept included launching a robotic Mars lander and Mars orbiter as early as 2020, to be followed by a human crew of four in 2024, and one in 2026 which would not be returning to Earth. Although the announcement garnered much international publicity, the concept has been criticized by scientists, engineers, and those in the aerospace industry.[11] Mars One is noted as being very short on funding, lacking critical concepts about hardware, life support, electrical power supply, and has been criticized as glossing over logistics, medical concerns, and protection against space radiation.[12][13][14][15][16][17][18][19][20] The concept has been called a suicide mission in academia, spaceflight, and international news.[6][17][12]

By February 2015, two conceptual studies were done by contractors.[21] Despite the criticism and lack of funding, about 2,700 people applied to become one of the 24 finalists "to settle Mars".[7]

In December 2013, Mars One announced its concept of a robotic precursor mission. Originally scheduled for launch in 2020, the roadmap called for the launch to occur in 2022.[22] If funded, the robotic lander would be "built by Lockheed Martin based on the design used for NASA's Phoenix and InSight landers, as well as a communications orbiter built by Surrey Satellite Technology Ltd."[23] In February 2015, Lockheed Martin and Surrey Satellite Technology confirmed that contracts on the initial study phase begun in late 2013 had run out and additional contracts had not been received for further progress on the robotic missions. Plans were set in motion to raise the US$200 million needed to support the initial robotic mission,[21][23] but some critics[who?] did not find the economic plans to raise money from private investors and exclusive broadcasting rights to be sufficient to support the initial, or follow-on, mission(s).

Mars One selected a second-round pool of astronaut candidates in 2013. Mars One received interest from over 200,000 applicants for the first round. However, as candidate Joseph Roche asserted, the number of initial applicants who completed the application process was only 2,761,[24] which Mars One later confirmed via YouTube video.[25] The second-round pool was whittled down to 705 candidates (418 men and 287 women) in the beginning of May 2014. 353 were removed due to personal considerations.[26] After the medical physical requirement, 660 candidates remained.[25] The third round of candidate selection concluded in 2015. The remaining 100 candidates, known as The Mars 100, consisted of 50 men and 50 women who were slated to move forward to the next round, where 40 individuals would have been chosen through an interview process.[27]

On 30 June 2014, it was made public that Mars One was seeking financial investment through a bidding process to send company experiments to Mars. The experiment slots would go to the highest bidder and would include company-related ads, and the opportunity to have the company name on the robotic lander that was proposed to carry the experiments to Mars in 2018.[28]

In a video posted on 19 March 2015, Lansdorp said that because of delays in funding the robotic precursor mission, the first crew would not set down on Mars until 2027.[29][12] Following the criticism reported in The Space Review in October 2016 about funding mechanisms,[30] Mars One created Mars One Ventures.[31] In late 2016 Mars One had changed its first crewed mission date to 2032.[32]

In December 2013, mission concept studies for a robotic Mars lander were contracted with Lockheed Martin for a demonstration mission concept. It would be based on the design of the successful 2007 NASA Phoenix lander,[23][33] and provide proof of concept for a subset of the key technologies for a later human settlement on Mars.[34] Upon submission of Lockheed Martin's Proposal Information Package,[33] Mars One released a Request for Proposals[35] for the various payloads on the lander. The total payload mass of 44kg was divided among the seven payloads as follows:[35]

A robotic rover was proposed to be launched to Mars in 2022, in order to scout a landing site for the 2027 lander and a site for the Mars One colony. At the same time, a communication satellite would be launched, enabling continuous communication with the future landed assets. For 2024, six cargo missions were proposed, in close succession, consisting of two living units, two life-support units, and two supply units; a spacecraft transporting four astronauts was proposed to meet a transit vehicle bound for Mars. For 2025, the landing module transporting four astronauts was proposed to land on Mars. They envisioned the crew to be met by the rover, and taken to the Mars One colony.[36]

Notes:^a The initial concept timeline slipped 2 times, with a 2-year delay each time.[44]^b Work on robotic missions was suspended pending further review and future contract direction in February 2015.[21]^c SpaceX had no contracts with MarsOne and the project did not appear on their launch manifest.[45]

The Mars One team consisted of Chief Executive Officer and co-founder Bas Lansdorp, Chief Technical Officer and co-founder Arnold Wielders, Chief Medical Officer Norbert Kraft, Mission Concept Artist Bryan Versteeg, Senior Marketing Strategist KC Frank, and Chief Information Officer Tom Van Braeckel.[46]

Mars One's team of advisers consisted of over 30 industry and scientific experts,[47] including Mason Peck, Peter Smith, James R. Kass, K.R. Sridhara Murthi, Esther Dyson, and Robert Zubrin.

Mars One was not an aerospace company and would not have manufactured hardware.[5] Lansdorp had assumed all major components would be available in the aerospace market,[48] and had said Mars One had identified at least one potential supplier for each component of the mission.[49][50]

SpaceX mentioned in 2014 that they had been contacted by Mars One, but that accommodating Mars One requirements would require some additional work and that such action was not a part of the current focus of SpaceX.[51] SpaceX had no contracts with Mars One.[52][53] The first Mars One cargo mission to Mars was proposed to launch by 2022, followed by a crewed mission in 2024,[54] but without funds, hardware, and without a launcher it did not happen.[55]

A hypothetical crewed interplanetary spacecraft, for which there were no concept design studies, was to have been assembled in low Earth orbit and comprise two propellant modules: a Transit Living Module (discarded just before arrival at Mars) and a lander (see "Human Lander" below).[48][56] In 2012, Mars One speculated that the Transit Living Module might potentially be designed and built by Thales Alenia Space.[57]

A concept study was produced by Lockheed Martin for a demonstration lander based on the 2008 Phoenix lander.[42][23][33]

In December 2013 Mars One awarded a contract to Surrey Satellite Technology for a study of the satellite technology required to provide 24/7 communication between Earth and the Mars base.[58][59] Mars One proposed at least two satellites, one in areostationary orbit above Mars and a second at the Earth Sun L4 or L5 point to relay the signal when Mars blocks the areosynchronous satellite from line of sight to Earth.[59] It is possible that a third satellite would be required to relay the signal on the rare occasions when the Sun blocks the first relay satellite from line of sight with Earth.[59]

An early notional crewed lander was shown in concept art[when?] as a 5-meter (16ft)-diameter variant of SpaceX Red Dragon, but SpaceX declined to collaborate with Mars One.[45]

The crewed Mars rover was to have been unpressurized and claimed to be designed to be capable of supporting travel distances of 80km (50 miles).[60] One mentioned supplier for the rover in 2012 was Astrobotic Technology.[57][non-primary source needed]

On 12 March 2013, Paragon Space Development Corporation was contracted to develop concepts for life support and the Mars Surface Exploration Spacesuit System, and it included the pressure suit and the Portable Life Support System (PLSS) that could have permitted survival outside the habitat. The suggested supplier of the suits was ILC Dover.[61] The study was stated to be finished late summer 2013; Mars One released the results of this (ECLSS portion only) study to the public in June 2015,[62][63][64] but did not fund its research and development.

In 2013, Mars One signed a contract with Paragon Space Development Corporation, for a preliminary life support system concept study based on the International Space Station.[65] The idea was criticized because that system, as modern as it is, requires significant maintenance and supplies not available while on Mars.[66][67]

The application was available from 22 April 2013 to 31 August 2013.[68][69] This first application consisted of applicant's general information, a motivational letter, a rsum and a video. More than 200,000 people expressed interest. By 9 September 2013, 4,227 applicants[70] had paid their registration fee and submitted public videos in which they made their case for going to Mars.[71] The application fee varies from US$5 to US$75 (the amount depending on the relative wealth of the applicant's country).[72]

Distribution of the 1,058 applicants selected for Round 2 according to their academic degree[73]

Other (37%)

The applicants selected in this round were declared on 30 December 2013. A total of 1,058 applicants from 107 countries were selected.[23] The gender split was 586 males (55.4%) and 472 females (44.6%). Among the people that were selected to move on to round two, 159 have a master's degree, 347 have bachelor's degrees and 29 have Doctor of Medicine (M.D.) degrees. The majority of the applicants are under 36 and well educated.[74][75]

Medically cleared candidates were interviewed, and 50 men and 50 women from the total pool of 660 from around the world were selected to move on to the third round of the astronaut selection process:[76][77]

Applicants were remotely interviewed and recorded by Mars One over a relatively short Skype/SparkHire call regarding Martian-related orbital, temp/pressure, geological and historical parameters and the specific elements of the Mars One one-way mission.[24][78][79] Joseph Roche, one of the finalists, has accused the selection process of being based on a point system that is primarily dependent on how much money each individual generated or gave to the Mars One organization, despite many of the round three selectees having not spent any money in the process, apart from the application fee, which varied as a function of each applicant's country GDP.[24][78][79] Lansdorp acknowledges a "gamification" point system but denies that selection is based on money earned.[79] Roche also stated that if paid for interviews, they are asked to donate 75% of the payment to Mars One.[24][79] This was confirmed by Lansdorp.[24][79]

The company had intended that the regional selection may be broadcast as a reality television show documenting group challenges, but no deal was reached with TV producers. The audience was to select one winner per region, and the experts could select additional participants, if needed, to continue to the international level.[68] Of the 100 candidates, 40 individuals were to be chosen through an interview process.[80] Round 3 would take place after enough funding is secured for an "Earth-based simulation outpost."[80]

The remaining 40 candidates would be spending nine days in an isolation unit. The candidates are observed closely to examine how they act in situations of prolonged close contact with one another. It takes a specific team dynamic to be able to handle this, and the goal of this selection round is to find those that are best suited for this challenge. After the isolation round, 30 candidates would be chosen to undergo in a Mars Settler Suitability Interview.[81]

The Mars Settler Suitability Interview would have measured suitability for long-duration space missions and Mars settlement, and would last approximately 4 hours. 24 candidates would be selected after the interview and would be offered full-time employment with Mars One.[81]

From the previous selection series, six groups of four were to become full-time employees of the Mars One, after which they were to train for the mission. An MIT team noted that since the company is not developing the technology needed, it is unclear what the astronauts would be training for.[17][20] Mars One has stated that the teams selected were going to undergo a battery of training, ranging from psycho-social skills to engineering and scientific observation.[82]

Mars One funding came from astronaut application fees, donations, undisclosed private investment, intellectual property (IP) rights, and mostly, the potential sale of future broadcasting rights.[7][72] Over three-quarters of the funds reportedly went to concept design studies. Mars One states that "income from donations and merchandise have not been used to pay salaries". To date, no financial records have been released for public viewing.[83] Mars One initially estimated a one-way trip, excluding the cost of maintaining four astronauts on Mars until they die, at US$6 billion.[84] Lansdorp has declined questions regarding the cost estimate.[85]

Mars One's investment of revenues[86]

Concept design studies (78.3%)

Travel expenses (11.6%)

Legal expenses (3.3%)

Website maintenance (2.4%)

Communications (2.3%)

Office and other (2.1%)

A proposed global reality-TV show was intended to provide funds to finance the expedition, however, no such television show emerged and no contracts were signed. The astronaut selection process (with some public participation) was to be televised and continue on through the first years of living on Mars.[87]

Discussions between Endemol started in June 2014,[88][failed verification] producers of the Big Brother series, and Mars One ended with Endemol subsidiary Darlow Smithson Productions issuing a statement in February 2015 that they "were unable to reach agreement on the details of the contract" and that the company was "no longer involved in the project."[89] Lansdorp updated plans to no longer include live broadcasts, but instead would rely on documentary-style short films produced by the company Stateless Media.[90][91]

On 31 August 2012, the company announced that funding from its first sponsors were received,[84] and that the funds were used mostly to pay for two conceptual design studies performed by aerospace suppliers Lockheed Martin (lander) and Surrey Satellite Systems (orbiter).[84]

On 3 March 2014 Mars One announced a working agreement with Uwingu, stating that the program would use Uwingu's map of Mars in all of their missions.[92][93]

Total (from 113 countries): $928,888

Since the official announcement of their conversion to a Stichting foundation, Mars One began accepting donations through their website. As of 4 July 2016, Mars One had received $928,888 in donations and merchandise sales.[94] The 2016 donation update adds the Indiegogo campaign ($313,744) to the private donation and merchandise total.

On 10 December 2013, Mars One set up a crowdfunding campaign on Indiegogo to help fund a 2018 demonstration robotic mission that was not built. The alleged 2018 mission would have included a lander and a communications satellite to prove technologies in addition to launch and landing. The campaign goal was to raise US$400,000 by 25 January 2014. Since the ending date was drawing near, they decided to extend the ending date to 9 February 2014. By the end of the campaign, they had received $313,744. Indiegogo received 9% ($28,237).[95]

Trading of the shares of Mars One Ventures AG, listed on the Frankfurt Stock Exchange, was suspended on 5 February 2019 for non-compliance with the FSE regulations when the number of shares was increased in 2017.[96] In February 2019, it was reported that Mars One had declared bankruptcy in a Swiss court on 15 January 2019, and was permanently dissolved as a company.[97][98] The total debt is approximately 1 million.[96]

Mars One received a variety of criticism, mostly relating to medical,[99] technical and financial feasibility. There were also unverified claims that Mars One was a scam designed to take as much money as possible from donors, including reality show contestants.[100][101] Many criticized the project's US$6 billion budget as being too low to successfully transport humans to Mars, to the point of being delusional.[20][102] A similar project study by NASA estimated the cost of such a feat at US$100 billion, although that included transporting the astronauts back to Earth. Objections had also been raised regarding the reality TV project associated with the expedition. Given the transient nature of most reality TV ventures, many believed that as viewership declined, funding could significantly decrease, thereby harming the entire expedition. Further, contestants reported that they were ranked based on their donations and funds raised.[100][103]

John Logsdon, a space policy expert at George Washington University, criticized the program, saying it appeared to be a scam[102] and not "a credible proposition".[104]

Chris Welch, director of the Masters Programs at the International Space University, said "Even ignoring the potential mismatch between the project income and its costs and questions about its longer-term viability, the Mars One proposal does not demonstrate a sufficiently deep understanding of the problems to give real confidence that the project would be able to meet its very ambitious schedule."[105]

Gerard 't Hooft, theoretical physicist and ambassador[106] to Mars One, has stated that he thought both their proposed schedule and budget were off by a factor of ten.[24][107] He said he still supported the project's overall goals.[107]

A space logistics analysis conducted by PhD candidates at the Massachusetts Institute of Technology revealed that the most optimistic of scenarios would require 15 Falcon Heavy launches that would cost approximately $4.5 billion.[17] They concluded that the reliability of Environmental Control and Life Support systems (ECLS), the Technology Readiness Levels (TRL), and in situ resource utilization (ISRU) would have to be improved. Additionally, they determined that if the costs of launch were also lowered dramatically, together this would help to reduce the mass and cost of Mars settlement architecture.[17] The environmental system would result in failure to be able to support human life in 68 days if fire safety standards on over-oxygenation were followed, due to excessive use of nitrogen supplies that would not then be able to be used to compensate leakage of air out of the habitat, leading to a resultant loss in pressurization, ending with pressures too low to support human life.[17] Lansdorp replied that although he has not read all the research, supplier Lockheed Martin said that the technologies were viable.[108]

Another serious concern uncovered in the research conducted by MIT was replacement parts. The PhD candidates estimated the need for spare parts in a Mars colony based on the failure rates of parts on the ISS. They determined that a resupply mission every two years would be necessary unless a large space in the initial launch were to be reserved for extra materials. Lansdorp commented on this saying, "They are correct. The major challenge of Mars One is keeping everything up and running. We don't believe what we have designed is the best solution. It's a good solution."[108]

In March 2015, one of the Mars One finalists, Joseph Roche,[109] stated to media outlets that he believed the mission to be a scam. Roche holds doctorate degrees in physics and astrophysics, and shared many of his concerns and criticisms of the mission. These claims include that the organization lied about the number of applicants, stating that 200,000 individuals applied versus Roche's claim of 2,761, and that many of the applicants had paid to be put on the list. Furthermore, Roche claimed that Mars One was asking finalists for donations from any money earned from guest appearances (which would amount to a minimal portion of the estimated $6 billion required for the mission). Finally, despite being one of 100 finalists, Roche himself never spoke to any Mars One employee or representative in person, and instead of psychological or psychometric testing as is normal for astronaut candidates (especially for a lengthy, one-way mission), his interview process consisted of a 10-minute Skype conversation.[100][110]

In April 2015, Mars One's CEO Bas Lansdorp admitted that their 12-year plan for landing humans on Mars by 2027 was mostly fiction.[12]

Robert Zubrin, advocate for crewed Martian exploration, said "I don't think the business plan closes it. We're going to go to Mars, we need a billion dollars, and we're going to make up the revenue with advertising and media rights and so on. You might be able to make up some of the money that way, but I don't think that anyone who is interested in making money is going to invest on that basis invest in this really risky proposition, and if you're lucky you'll break even? That doesn't fly."[111] Despite his criticisms, Zubrin became an adviser to Mars One on 10 October 2013.[112]

Canadian former astronaut Julie Payette said during the opening speech for an International Civil Aviation Organization conference that she did not think Mars One "is sending anybody anywhere".[79]

In January 2014, German former astronaut Ulrich Walter strongly criticized the project for ethical reasons. Speaking with Tagesspiegel, he estimated the probability of reaching Mars alive at only 30%, and that of surviving there more than three months at less than 20%. He said, "They don't care what happens to those people in space... If my tax money were used for such a mission, I would organize a protest."[113]

Space tourist Richard Garriott stated in response to Mars One, "Many have interesting viable starting plans. Few raise the money to be able to pull it off."[114]

Former astronaut Buzz Aldrin said in an interview that he wants to see humans on Mars by 2035, but he does not think Mars One will be the first to achieve it.[115]

Wired magazine gave it a plausibility score of 2 out of 10 as part of their 2012 Most Audacious Private Space Exploration Plans.[116]

The project lacked current funding as well as sources for future funding.[117] The organization had no spacecraft or rocket in development or any contracts in place with companies that could provide a spacecraft or rocket. While plans point to SpaceX for both resources, the company had no contracts with Mars One in an industry that typically plans contracts decades in advance.[45]

More:

Mars One - Wikipedia

Human mission to Mars – Wikipedia

Proposed concepts

The idea of sending humans to Mars has been the subject of aerospace engineering and scientific studies since the late 1940s as part of the broader exploration of Mars. Some have also considered exploring the Martian moons of Phobos and Deimos.[1] Long-term proposals have included sending settlers and terraforming the planet. Proposals for human missions to Mars came from e.g. NASA, Russia, Boeing, and SpaceX. As of 2022, only robotic landers and rovers have been on Mars. The farthest humans have been beyond Earth is the Moon.

Conceptual proposals for missions that would involve human explorers started in the early 1950s, with planned missions typically being stated as taking place between 10 and 30 years from the time they are drafted.[2] The list of crewed Mars mission plans shows the various mission proposals that have been put forth by multiple organizations and space agencies in this field of space exploration. The plans for these crews have variedfrom scientific expeditions, in which a small group (between two and eight astronauts) would visit Mars for a period of a few weeks or more, to a continuous presence (e.g. through research stations, colonization, or other continuous habitation).[citation needed] By 2020, virtual visits to Mars, using haptic technologies, had also been proposed.[3]

Meanwhile, the unmanned exploration of Mars has been a goal of national space programs for decades, and was first achieved in 1965 with the Mariner 4 flyby. Human missions to Mars have been part of science fiction since the 1880s, and more broadly, in fiction, Mars is a frequent target of exploration and settlement in books, graphic novels, and films. The concept of a Martian as something living on Mars is part of the fiction.

The energy needed for transfer between planetary orbits, or delta-v, is lowest at intervals fixed by the synodic period. For EarthMars trips, the period is every 26 months (2 years, 2 months), so missions are typically planned to coincide with one of these launch periods. Due to the eccentricity of Mars's orbit, the energy needed in the low-energy periods varies on roughly a 15-year cycle[4] with the easiest periods needing only half the energy of the peaks.[5] In the 20th century, a minimum existed in the 1969 and 1971 launch periods and another low in 1986 and 1988, then the cycle repeated.[4] The next low-energy launch period occurs in 2033.[6]

Several types of mission plans have been proposed, including opposition class and conjunction class,[5] or the Crocco flyby.[7] The lowest energy transfer to Mars is a Hohmann transfer orbit, which would involve a roughly 9-month travel time from Earth to Mars, about 500 days (16mo) at Mars to wait for the transfer window to Earth, and a travel time of about 9 months to return to Earth.[8][9] This would be a 34-month trip.

Shorter Mars mission plans have round-trip flight times of 400 to 450 days,[10] or under 15 months, but would require significantly higher energy. A fast Mars mission of 245 days (8.0 months) round trip could be possible with on-orbit staging.[11] In 2014, ballistic capture was proposed, which may reduce fuel cost and provide more flexible launch windows compared to the Hohmann.[12]

In the Crocco grand tour, a crewed spacecraft would get a flyby of Mars and Venus in under a year in space.[13] Some flyby mission architectures can also be extended to include a style of Mars landing with a flyby excursion lander spacecraft.[14] Proposed by R. Titus in 1966, it involved a short-stay lander-ascent vehicle that would separate from a "parent" Earth-Mars transfer craft prior to its flyby of Mars. The Ascent-Descent lander would arrive sooner and either go into orbit around Mars or land, and, depending on the design, offer perhaps 1030 days before it needed to launch itself back to the main transfer vehicle.[14] (See also Mars flyby.)

In the 1980s, it was suggested that aerobraking at Mars could reduce the mass required for a human Mars mission lifting off from Earth by as much as half.[15] As a result, Mars missions have designed interplanetary spacecraft and landers capable of aerobraking.[15]

A number of unmanned spacecraft have landed on the surface of Mars, while some, such as the Schiaparelli EDM (2016), have failed what is considered a difficult landing. The Beagle2 failed in 2003. Among the successes:

When an expedition reaches Mars, braking is required to enter orbit. Two options are available: rockets or aerocapture. Aerocapture at Mars for human missions was studied in the 20th century.[16] In a review of 93 Mars studies, 24 used aerocapture for Mars or Earth return.[16] One of the considerations for using aerocapture on crewed missions is a limit on the maximum force experienced by the astronauts. The current scientific consensus is that 5 g, or five times Earth gravity, is the maximum allowable deceleration.[16]

Conducting a safe landing requires knowledge of the properties of the atmosphere, first observed by Mariner 4, and a survey of the planet to identify suitable landing sites. Major global surveys were conducted by Mariner 9 and Viking 1 and two orbiters, which supported the Viking landers. Later orbiters, such as Mars Global Surveyor, 2001 Mars Odyssey, Mars Express, and Mars Reconnaissance Orbiter, have mapped Mars in higher resolution with improved instruments. These later surveys have identified the probable locations of water, a critical resource.[17]

A primary limiting factor for sending humans to Mars is funding. In 2010, the estimated cost was roughly US$500 billion, though the actual costs are likely to be more.[18] Starting in the late 1950s, the early phase of space exploration was conducted as much to make a political statement as to make observations of the solar system. However, this proved to be both wasteful and unsustainable, and the current climate is one of international cooperation, with large projects such as the International Space Station and the proposed Lunar Gateway being built and launched by multiple countries.[citation needed]

Critics argue that the immediate benefits of establishing a human presence on Mars are outweighed by the immense cost, and that funds could be better redirected towards other programs, such as robotic exploration. Proponents of human space exploration contend that the symbolism of establishing a presence in space may garner public interest to join the cause and spark global cooperation. There are also claims that a long-term investment in space travel is necessary for humanity's survival.[18]

One factor reducing the funding needed to place a human presence on Mars may be space tourism. As the space tourism market grows and technological developments are made, the cost of sending humans to other planets will likely decrease accordingly. A similar concept can be examined in the history of personal computers: when computers were used only for scientific research, with minor use in big industry, they were big, rare, heavy, and costly. When the potential market increased and they started to become common in many homes (in Western and developed countries) for the purpose of entertainment such as computer games, and booking travel/leisure tickets, the computing power of home devices skyrocketed and prices plummeted.[19]

Several key physical challenges exist for human missions to Mars:[23]

Some of these issues were estimated statistically in the HUMEX study.[36]Ehlmann and others have reviewed political and economic concerns, as well as technological and biological feasibility aspects.[37] While fuel for roundtrip travel could be a challenge, methane and oxygen can be produced using Martian H2O (preferably as water ice instead of liquid water) and atmospheric CO2 with mature technology.[38]

Robotic spacecraft to Mars are currently required to be sterilized. The allowable limit is 300,000 spores on the exterior of general craft, with stricter requirements forspacecraft bound for "special regions" containing water.[39][40] Otherwise there is a risk of contaminating not only the life-detection experiments but possibly the planet itself.[41]

Sterilizing human missions to this level is impossible, as humans are host to typically a hundred trillion (1014) microorganisms of thousands of species of the human microbiota, and these cannot be removed. Containment seems the only option, but it is a major challenge in the event of a hard landing (i.e. crash).[42] There have been several planetary workshops on this issue, but with no final guidelines for a way forward yet.[43] Human explorers would also be vulnerable to back contamination to Earth if they become carriers of microorganisms.[44]

Over the past seven decades, a wide variety of mission architectures have been proposed or studied for human spaceflights to Mars. These have included chemical, nuclear, and electric propulsion, as well as a wide variety of landing, living, and return methodologies.

A number of nations and organizations have long-term intentions to send humans to Mars.

Significant technological hurdles need to be overcome for human spaceflight to Mars.

Entry into the thin and shallow Martian atmosphere will pose significant difficulties with re-entry; compared to Earth with much denser atmosphere, any spacecraft will descend very rapidly to the surface and must be slowed down.[53] A heat shield has to be utilized.[54] NASA is carrying out research on retropropulsive deceleration technologies to develop new approaches to Mars atmospheric entry. A key problem with propulsive techniques is handling the fluid flow problems and attitude control of the descent vehicle during the supersonic retropropulsion phase of the entry and deceleration.[55]

A return mission to Mars will need to land a rocket to carry crew off the surface. Launch requirements mean that this rocket would be significantly smaller than an Earth-to-orbit rocket. Mars-to-orbit launch can also be achieved in single stage. Despite this, landing an ascent rocket on Mars will be difficult. Re-entry for a large rocket will be difficult.[citation needed]

In 2014, NASA proposed the Mars Ecopoiesis Test Bed.[56]

One of the medical supplies that might be needed is a considerable mass of intravenous fluid, which is mainly water, but contains other substances so it can be added directly to the human blood stream. If it could be created on the spot from existing water, this would reduce mass requirements. A prototype for this capability was tested on the International Space Station in 2010.[57]

A person who is inactive for an extended period of time loses strength and muscle and bone mass. Spaceflight conditions are known to cause loss of bone mineral density in astronauts, increasing bone fracture risk. Last mathematical models predict 33% of astronauts will be at risk for osteoporosis during a human mission to Mars.[30] A resistive exercise device similar to ARED would be needed in the spaceship.

While humans can breathe pure oxygen, usually additional gases such as nitrogen are included in the breathing mix. One possibility is to take in situ nitrogen and argon from the atmosphere of Mars, but they are hard to separate from each other.[58] As a result, a Mars habitat may use 40% argon, 40% nitrogen, and 20% oxygen.[58]

An idea for keeping carbon dioxide out of the breathing air is to use reusable amine-bead carbon dioxide scrubbers.[59] While one carbon dioxide scrubber filters the astronaut's air, the other is vented to the Mars atmosphere.[59]

Some missions may be considered a "Mission to Mars" in their own right, or they may only be one step in a more in-depth program. An example of this is missions to Mars's moons, or flyby missions.

Many Mars mission concepts propose precursor missions to the moons of Mars, for example a sample return mission to the Mars moon Phobos[60] not quite Mars, but perhaps a convenient stepping stone to an eventual Martian surface mission. Lockheed Martin, as part of their "Stepping stones to Mars" project, called the "Red Rocks Project", proposed to explore Mars robotically from Deimos.[62][63]

Use of fuel produced from water resources on Phobos or Deimos has also been proposed.

An uncrewed Mars sample return mission (MSR) has sometimes been considered as a precursor to crewed missions to Mars's surface.[64] In 2008, the ESA called a sample return "essential" and said it could bridge the gap between robotic and human missions to Mars.[64] An example of a Mars sample return mission is Sample Collection for Investigation of Mars.[65] Mars sample return was the highest priority Flagship Mission proposed for NASA by the Planetary Decadal Survey 20132022: The Future of Planetary Science.[66] However, such missions have been hampered by complexity and expense, with one ESA proposal involving no less than five different uncrewed spacecraft.[67]

Sample return plans raise the concern, however remote, that an infectious agent could be brought to Earth.[67] Regardless, a basic set of guidelines for extraterrestrial sample return has been laid out depending on the source of sample (e.g. asteroid, Moon, Mars surface, etc.)[68]

At the dawn of the 21st century, NASA crafted four potential pathways to Mars human missions,[69] of which three included a Mars sample return as a prerequisite to human landing.[69]

The rover Perseverance, which landed on Mars in 2021, is equipped with a device that allows it to collect rock samples to be returned at a later date by another mission.[70] Perseverance as part of the Mars 2020 mission was launched on top of an Atlas V rocket on 30 July 2020.[71]

Starting in 2004, NASA scientists have proposed to explore Mars via telepresence from human astronauts in orbit.[72][73]

A similar idea was the proposed "Human Exploration using Real-time Robotic Operations" mission.[74][75]

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Human mission to Mars - Wikipedia

Nostradamus’ New Year 2023 Predictions: From Cannibalism On Earth And World War 3; Heres Some Shocking Claims Made By The French Astrologer – SpotboyE

Nostradamus' New Year 2023 Predictions: From Cannibalism On Earth And World War 3; Heres Some Shocking Claims Made By The French Astrologer  SpotboyE

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Nostradamus' New Year 2023 Predictions: From Cannibalism On Earth And World War 3; Heres Some Shocking Claims Made By The French Astrologer - SpotboyE

Is colonizing Mars even a good idea? You can’t breathe, after all

BREVARD COUNTY, Fla. Elton John might have said it best in his iconic song"Rocket Man""Mars ain't the kind of place to raise your kids."

More than 50 years after we sent humans to the moon the closest celestial body to Earth the plan is still to head to Mars, something many astronauts who have flown in space thought we would have alreadyaccomplished.

"I just assumed by the time I got to be old enough to go into the space program, you know we'd be living on Mars or I'd be working on Mars just as a scientist," Mae Jemison, thefirst African American woman in space,told university students at the Kennedy Space Center Visitor Complex in December 2019.

But despite the fact humankind has been unable to send anyone to another place in the universe besides the moon, there are still many with the hopes and expectation that we will become a multi-planetary species in the near future, starting with our red next-door neighbor.

Billionaire entrepreneurs like Elon Musk and aspiring young astronauts like Alyssa Carson, a sophomore studying astrobiology at Florida Tech, hope to one day live on Mars.

"Eventually the sun will run out of fuel to burn and conditions on Earth are going to be very different from our normal regular life now," Carson told Florida Today, part of the USA TODAY Network. "It's not necessarily saying Mars is the savior here but Mars is that first step in getting people a bit more accustomed to even thinking about living on other planets and being able to colonize someplace else."

Even Musk's aerospace company, SpaceX, was founded with the "ultimate goal of enabling people to live on other planets," according to its website.

But how feasible is that?Do we want to settle on a planet where we can't even breathe?

According to NASA administrator Jim Bridenstine, we have the technological capability to go to Mars. The problem is money, or lack thereof.

Under Space Policy Directive 1, President Donald Trump tasked NASA with sending the next man and first woman to the moon by 2024 and then eventually heading on to Mars. But this isn't the first time a president has said we're going back to the moon or we're finally sending humans to the Red Planet.

After John F. Kennedy made his declaration that we would "put a man on the moon," several other presidents have tried to walk in his footsteps. But unlike Kennedy, none have come close to succeeding.

On the 20th anniversary of Apollo 11 in 1989, President George H.W.Bush said we would return to the moon and go on to Mars, but in the end, the priceprovedtoo high.

His sonPresident George W. Bush echoed the same goal.

Under the Constellation program, the plan was to return to the moon by 2020 and then head to Mars, but the project was ultimately scrapped after a series of delays and increasingly high costs.

President Barack Obama also hoped to go to Mars. Instead of proposing returning to the moon, however, Obama said we should send astronauts to an asteroid by 2025 before moving on to Mars. Congressional Republicans rejected the idea, andnothing came to fruition.

NASA Administrator discusses crewed missions to Mars

NASA Administrator Jim Bridenstine discusses NASA's ability to send humans to Mars

Rachael Joy, Florida Today

Then cameTrump's turn.

After heading back to the moon in the next four years under the Artemis program, the next big milestone would be a trip to Mars.

But again, the problem boils down to spending what's necessary to send astronauts there, Bridenstine said.

"The question isn't whether or not we're technologically capable of doing it, because we are. The question is whether or not we have the political will to do it,"hetold reporters at Kennedy Space Center in July for NASA's Mars Perseverance rover launch.

The Apollo program, Bridenstine pointed out, was driven by the need to beat the Soviet Union to the moon, which is why Congress appropriated vast sums of money to NASA. Today, that's no longer the case.

With no Cold War to encourage federal spending on the program, NASA instead is looking to international partners to help pay for any trip to Mars.

"Today we don't have thatlarge power competition that we had back then, but what we do have is we have international partners, we have commercial partners, we have technological advances that are so far beyond what we had in the 1960s," Bridenstine said. "So the answer is yes, we can do it. The question is: Will we receive the budgetto do it right now?"

It is unclear how much support the incoming Biden administrationis going to give the Artemis program.

Money isalso anissue for SpaceX's Mars plans.

As a private company, SpaceX can't rely solely on taxpayer dollars to send humans there. Instead, the aerospace company is looking for other revenue streams to help pay for a Mars mission, such as its Starlink internet constellation.

Aside from providing internet connection to people living in remote areas around the world, Starlink will also help fund SpaceX's goal of having people live on Mars or at least, that's the plan.

But first, Starlink has to be successful.

Not everyone believes sending people to live on Mars is the right move, however.

Bill Nye, CEO for the Planetary Society and famously known as "Bill Nye the Science Guy" for his TV show that aired in the '90s, is one of those who doesn't believe in setting up camp on Mars.

"I would love to go to space, you guys.But this idea of living on another world where we can't be outside just doesn't sound that appealing," Nye told reporters in 2019 before the launch of the Light Sail 2 project he and other Planetary Society members had worked on.

"You think you want to go to Venus?We'd be vaporized in a second, way less than a second," Nye said. "And then on Mars, there's nothing to breathe. There's nothing to breathe, people. It's not just there's nothing to eat, there's nothing to breathe. So, you know if you live in a dome and you go outside, you're going to put on a spacesuit and you're in another dome, like my good friend Sandy the squirrel," referencing the character from the children's TV show"SpongeBob SquarePants."

And as of now, that's really the only option for humans to live on Mars a dome. It would essentially be like how actor Matt Damon' character lived in the sci-fi film "The Martian."

Even the author of "The Martian," on which the sci-fi film is based, doesn't believe we're close to having a human settlement on Mars.

"Mars is horribly inhospitable," Andy Weir told Florida Today via email. "Though it's an awesome idea living on Mars it would be far easier to colonize Earth's ocean floor. There won't be a significant settlement on Mars until there's an economic reason for a city to exist there. Like Antarctica,the only people there are researchers because there's no reason to be there otherwise."

So like Nye, Weir isn't inclined live on Mars.

Bill Nye doesn't think humans should live on Mars

Bill Nye, CEO of the Planetary Society, talks to FLORIDA TODAY reporters Antonia Jaramillo and Rachael Joy about the idea of humans living on Mars.

Staff, FLORIDA TODAY

"Nope! I write about brave people, but I'm not one of them," Weir said."I like Earth and plan to stay."

Others argue there's another way to live on Mars that doesn't include living in a dome. The only problem is the logistics ofchanging the Martian landscape into one that can support human life.

Called "terraforming," this essentially involves transforming Mars into a more Earth-like habitat. It's what Musk has proposed doing and what astrophysicist Neil deGrasse Tyson believes would be best if humans were to live on Mars.

Elon Musk has a plan. Hes thinking of putting satellites in orbit that have big reflectors that focus sunlight that would otherwise miss the planet. Focus it down on the planet and just add more energy to the planet, heating it up, and if you do it right, you might be able to set sort of a chain reaction in place," deGrasse Tyson said in his podcast, "StarTalk."

"If everything is frozen and it gets warmer, youll evaporate more carbon dioxide, and thatll help trap more heat, and then thatll make it hotter to evaporate even more carbon dioxide," he said. "You get all of that out of the system and into the atmosphere. Then now its warm enough, now youre still mostly greenhouse gases, you still need oxygen to breathe. So now you put microorganisms that eat the CO2 and they release oxygen.

But terraforming Mars isn't going to happen anytime soon. Not only is the technology not available to do so, but the question also becomes, "How long would that take?"

Thats the big problem. Is it a thousand years, is it a million years? Or can you speed it up with some fast-acting microbes? This remains to be established, deGrasse Tyson said. But Im telling you that if were going to be a two-planet species, Im thinking you have to terraform Mars for that to happen.

Yet not everybody agrees with that tactic, especially because that would change the whole geology of Mars.

"Ive never been someone that has been a fan of terra-transforming a planet to make it more Earth-like. I think that the excitement of going to a different planet would be utilizing the in-situ resources that are there," NASA astronaut Christina Koch told deGrasse Tyson on his podcast.

"So, I would see something like a sustainable Mars establishment, to me, would always require some type of resupply, and even if thats just to make it livable and habitable in terms of what humans think of as habitable and livable, I think is the important thing. But using the in-situ resources as well, she said.

In other words, living in that dome-like structure.

Florida Tech professor and plant biochemist Andrew Palmer also believes using in-situ resources to live on Mars is the best plan.

He, along with other researchers at the universityare collaborating on how future Marssettlers can use the resources, namely the soil on Mars to grow their own food.

"So the whole premise of this project, it all falls under something that's called in-situ resource utilization, which is a simple way of just saying using what's already there. So what we want to do is establish how little do you need to bring from Earth in order to be self-sufficient," Palmer told Florida Today."Mars is about six months away. If something goes wrong on Mars and you're unable to get a rocket to Mars to rescue people, they need to have their own food."

By studying various simulated Martian soils, Palmer and his colleagues hope to determine what elseis neededto help grow crops on Mars, especially since the Martian soil may not be able to host plant life.

Florida Tech to find right Mars soil to grow plants on the red planet

Dr. Andrew Palmer , fellow professors and his grad students are working on growing plants in simulated Mars soil for sustainability on Mars.

Malcolm Denemark, FLORIDA TODAY

"IfI go take a sample of soil on Florida Tech campus and then I went out beachside and I took a soil sample there, those are not going to be the same, and the same is true on Mars," Palmer said.

That's problematic for future Mars settlers. What if they get to Mars and all of a sudden they can't grow anything there?

To avoid that, Palmer suggests sending a robotic greenhouse in advance.

"In our mind, one way to do this would be you land robots there six months in advance, and you inflate a tent and you start working on the soil, all remotely, and colonists get there and the soil is ready to grow," Palmer said.

When discussing what crops would be best to grow on Mars and what other nutrients settlers would need, Palmer recommends crops like potatoes, corn, radishes andkale. As for protein, Palmer says, insects are the way to go.

"Trying to grow a cow on Mars, that's a huge amount of resource investment,but growing insects, it's a very cheap investment, relatively speaking," Palmer said.

The other option could be to grow synthetic meats.

Besides just the different eating habits and living arrangements humans would have to get accustomed to if they lived on Mars, life would be very different from Earth, perhaps more environmentally friendly, becausenearly everything would have to be recycled.

But that might not be all that enticing to future colonists.

"In a Martian colony, (the settlers) willhave never not had water that was made fromprevious urine, andtheir entire world will be completely recycled and reused," Palmer said.

But even with a Mars establishment, others don't believe Mars should be the final destination or a "colony" at all.

"I think going to Mars is fineit's not a final place to go. I mean, you know, it's like just going to the moon but it's a little further out," the late Apollo 15 astronaut Al Worden told Florida Today in November 2019.

"When the sun burns out, Mars is going to go too, along with the Earth," Worden said. "We'd be better off solving all the problems we've got here (on Earth) than colonizing Mars. What we need is an Earth-like planet in another solar system somewhere."

But if humans haven't even been able to head back to the moon since 1972, the odds of trying to head to a planet in another solar system isnothingmore thanscience fiction at this point.

Apollo 15 astronaut Al Worden doesn't believe in colonizing Mars

At Florida Tech, Apollo 15 astronaut Al Worden explained why he doesn't believe in colonizing Mars & where we could eventually live (Alpha Centauri)

Rachael Joy, Florida Today

Technological challengesaside, will humans even live long enough to travel and settle on another planet?

"That's my greatest concern," Worden said. "We're not very good to each other here, and we don't seem to care about the things that will sustain this place to live in for a long time. I think we're doing more damage to ourselves and the planet that it may be of such an extent that we don't have to wait till the sun burns outwe're going to do it ourselves."

He's not the only one who thinks so.

In a July 2019 Pew Research Center study, 63% of Americans said NASA's top priorities should be using space to monitor key parts of Earths climate system. Meanwhile, only 13% believe sending astronauts to the moon should be a top priority. That figure jumps to a mere 18% for a crewed mission to Mars.

Former NASA Deputy Administrator Lori Garver wrote an op-ed piece for The Washington Postin 2019stating NASA should focus its resources on saving our planet instead of heading to other celestial bodies.

"The public is right about this. Climate change not Russia, much less China is todays existential threat. Data from NASA satellites show that future generations here on Earth will suffer from food and water shortages, increased disease and conflict over diminished resources," Garver said.

Instead of focusing on sending humans to the moon or Mars, Garver said, NASA should create a Climate Corps"in which scientists and engineers spend two years in local communities understanding the unique challenges they face, training local populations and connecting them with the data and science needed to support smart, local decision-making."

"Apollos legacy should not be more meaningless new goals and arbitrary deadlines," Garver said. "Lets not repeat the past. Lets try to save our future. Besides, humanitys intrinsic need to explore is driven by our need to survive."

The coronavirus pandemicleads toanother important question about interplanetary travel:What if we got stuck with another pandemic, only this time while humans were in space?

It's hard enough to live on a planet where you can't breathe, let alone have a highly contagious virus spreading like wildfire.

A key thing we have come to understand from COVID-19 is those with weaker immune systems have a harder time recovering. For the future explorers venturing to live on Mars, they might all end up having weak immune systems.

A study published last yearby NASA scientists revealed astronauts who have endured long space voyages such as the shuttle missions and International Space Station flightswere more vulnerable to diseasessuch as herpes, chickenpox and shingles.

The cause? Pretty much what youd expect from any potentially treacherous space voyage: stress.

So far, 47 out of 89 (53%) astronauts from short-duration space shuttle flights, and 14 out of 23 (61%) from long-duration ISS spaceflight missions shed at least one or more herpes viruses in their saliva or urine samples, the study states.

When astronauts venture out into space, they are faced with several extraterrestrial hazards, including cosmic radiation, microgravity and gravitational forces like acceleration and deceleration.

But those aren't the only stress factors they're exposed to. Throughout an astronaut's space mission, they are forced to endure social separation, confinement, sleep deprivation, circadian rhythm disruption and increased anxiety.

All this exposure contributes to dysregulation in the astronauts immune and endocrine systems.

So what does this mean for potentially longer space exploration missions and the humans embarking on those quests?

Although NASA believes there is no clinical risk to astronauts during orbital spaceflight, there is concern that during deep-space exploration missions there may be clinical risks related to viral shedding, lead study author Satish Mehta at Johnson Space Center told Florida Today via email.

The girl who wants to go to Mars

Alyssa Carson, 18 year old FIT student, has known she wanted to be an astronaut from a very young age and has been working towards that goal since childhood.

Malcolm Denemark, FLORIDA TODAY

Ultimately, the information gleaned from these space studies will shape the way we prepare for and design exploration-class missions, beyond the moon and Mars, where reactivation of latent viruses could result in increased risk for wide-ranging adverse medical events, according to the study.

Aside from the physical ramifications that living in space or other planets like Mars would cause on the human body, there's also a psychological toll that will affect those living far from Earth and their loved ones.

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Is colonizing Mars even a good idea? You can't breathe, after all

NASA Space Flight Medal – Wikipedia

Award

The NASA Space Flight Medal is a decoration of the National Aeronautics and Space Administration. According to its statutes, it is awarded "for significant achievement or service during individual participation as a civilian or military astronaut, pilot, mission specialist, payload specialist, or other space flight participant in a space flight mission."[1] In practice, the medal is bestowed upon any astronaut (US or foreign) who flies aboard a United States space mission, and typically every subsequent flight is honored with an additional award.

Multiple awards of the decoration are annotated either by award stars or oak leaf clusters (depending on the civilian or military status of the recipient and, if military, the branch of service). The NASA Space Flight Medal is also authorized for wear on active uniforms of the United States military and is worn after all military decorations.

For those who perform an act of gallantry or heroic action while engaged in a U.S. space mission, NASA also presents an award known as the Congressional Space Medal of Honor. This is separate award from the Medal of Honor which is a U.S. military decoration for extreme bravery.

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NASA Space Flight Medal - Wikipedia

Euthanasia | Definition, History, & Facts | Britannica

euthanasia, also called mercy killing, act or practice of painlessly putting to death persons suffering from painful and incurable disease or incapacitating physical disorder or allowing them to die by withholding treatment or withdrawing artificial life-support measures. Because there is no specific provision for it in most legal systems, it is usually regarded as either suicide (if performed by the patient himself) or murder (if performed by another). Physicians may, however, lawfully decide not to prolong life in cases of extreme suffering, and they may administer drugs to relieve pain even if this shortens the patients life. In the late 20th century, several European countries had special provisions in their criminal codes for lenient sentencing and the consideration of extenuating circumstances in prosecutions for euthanasia.

The opinion that euthanasia is morally permissible is traceable to Socrates, Plato, and the Stoics. It is rejected in traditional Christian belief, chiefly because it is thought to contravene the prohibition of murder in the Ten Commandments. The organized movement for legalization of euthanasia commenced in England in 1935, when C. Killick Millard founded the Voluntary Euthanasia Legalisation Society (later called the Euthanasia Society). The societys bill was defeated in the House of Lords in 1936, as was a motion on the same subject in the House of Lords in 1950. In the United States the Euthanasia Society of America was founded in 1938.

The first countries to legalize euthanasia were the Netherlands in 2001 and Belgium in 2002. In 1997 Oregon became the first state in the United States to decriminalize physician-assisted suicide; opponents of the controversial law, however, attempted to have it overturned. In 2009 the Supreme Court of South Korea recognized a right to die with dignity in its decision to approve a request by the family of a brain-dead woman that she be removed from life-support systems.

The potential of modern medical practice to prolong life through technological means has provoked the question of what courses of action should be available to the physician and the family in cases of extreme physical or emotional suffering, especially if the patient is incapable of choice. Passively doing nothing to prolong life or withdrawing life-support measures has resulted in criminal charges being brought against physicians; on the other hand, the families of comatose and apparently terminal patients have instituted legal action against the medical establishment to make them stop the use of extraordinary life support.

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Elon Musk Accused of Promoting QAnon in Latest Leftwing Fit of Rage …

Progressivism is one long fit of rage, constantly pushing toward the most absurd reaction to any given situation, and Elon Musk is currently its top target.

And because progressivism is one escalation after another, it was just a matter of time before Musk was connected to QAnon. It all started with a fairly innocuous tweet encouraging people to follow a rabbit emoji (i.e. the white rabbit). Then Caroline Orr Bueno, who studies disinformation and has half a million followers, showed up with this banger.

Apparently, they just give out doctorates like candy these days. The surest sign you are dealing with a deranged individual, though, is the fact that Bueno is a behavioral scientist living off the teat of academia. Thats an environment ripe for smelling ones own farts to the point of conspiratorial delusion.

Does anyone see an explicit call to follow QAnon in Musk posting a bunny emoji? If you dont, thats because one doesnt exist. Still, Beuno soldiered on into the bowels of QAnon trolling to find a few posts that confirm her priors.

That seems like a few less than 120 million people, but I dont have a doctorate in mathematics to know for sure. So are the above posts indicative of anything but a tiny number of people who like to troll left-wing academics? Nah, but Beuno thinks shes cracked the case, and thats the real entertainment value here. Over-educated individuals who have convinced themselves that their brilliance reveals a monster under every bed. You are just too much of a rube to see them.

In actuality, the opposite is true. Bueno isnt smart. Rather, shes so vapid as to have no possible argument outside of the most extreme, baseless interpretation. It couldnt possibly be that Musk has seen the Matrix or that hes a fan of Jefferson Airplane. No, its got to be that hes secretly QAnon, pushing his followers to join a domestic terrorist group.

Thats the same dynamic that leads the left to accuse those on the right of being nazis. Its beyond their mental capacity to argue for their policies in an affirmative manner. Instead, they fall on the lazy trope of comparing their opponents to genocidal maniacs because thats all they can come up with. They dont want to bear any scrutiny of their own positions so they attempt to simply disqualify the other side from consideration.

As to what Musk was actually talking about? Far from promoting QAnon, he was making a cryptic reference to a Twitter account that provided some stats on lockdowns and COVID-19 deaths. Reality is so much more boring than the leftwing mind.

I dont know what Musk will end up making off Twitter monetarily in the long run, but whatever it is, it will have been worth it. No man since Donald Trump has managed to cause the left more consternation, and that feels like a pretty good value.

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Ex-Twitter Executive: Elon Musk Is Putting Us In Harms Way By …

Twitters former head of trust and safety claimed Friday night that Twitter CEO Elon Musk was putting peoples lives in danger by revealing internal company documents showing how employees censored conservatives and a negative news story about then-presidential candidate Joe Bidens son.

Yoel Roth, Twitters former Sr. Director, Head of Trust & Safety, complained about Musks decision to release internal company communications through journalist Matt Taibbi about the companys censorship of the New York Posts Hunter Biden laptop story during the 2020 presidential election.

Taibbi tweeted out screenshots showing that company officialswere in regular contact with Democrats and censored content that Democrats wanted removed.

Publicly posting the names and identities of front-line employees involved in content moderation puts them in harms way and is a fundamentally unacceptable thing to do, Roth posted on Mastodon.

Musk said that he decided to release the information because it was necessary to restore public trust in the platform after it censored the Hunter Biden story.

One of the tweets published by Taibbi showed that Democrats flagged content from conservative actor James Woods to Twitters content moderation team for removal.

Woods joined Fox News host Tucker Carlson as Taibbi was releasing the internal information from Twitter.

Ive been a target of these people for six years. They have destroyed my career, Woods said. They have destroyed my livelihood. Theyve destroyed my faith in this country that my family has defended in the military since the Revolutionary War.

I can guarantee you one thing, more than anything else youll ever hear in your life, I will be getting a lawyer. I will be suing the Democratic National Committee. No matter what, whether I win or lose, I am going to stand up for the rights of every American, he said. Im not a celebrity, Im hardly recognizable anymore because my career has been destroyed by these very people.

If I have to be the flag-bearer for this, then so be it. Ill be proud to do it, Woods added.The government of the United States conspired to take my free speech and throw it in the gutter. And theres something that they should fear more than anything they have ever imagined in their wildest dreams. The most dangerous man, these corrupt, vile vermin is an American, whos not afraid of him, and Joe Biden, and all those rats who work with you at the DNC, to close down my speech, I am not afraid of you. And Im coming for you.

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Ex-Twitter Executive: Elon Musk Is Putting Us In Harms Way By ...

Serena Williams Husband Alexis Ohanian Targets Elon Musk as He Dishes Out Physics-Based Advice to the Controversial CEO – EssentiallySports

Serena Williams Husband Alexis Ohanian Targets Elon Musk as He Dishes Out Physics-Based Advice to the Controversial CEO  EssentiallySports

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Our Resort | Hedonism II

Departure City

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Our Resort | Hedonism II

Hedonism | Philosophy & Definition | Britannica

hedonism, in ethics, a general term for all theories of conduct in which the criterion is pleasure of one kind or another. The word is derived from the Greek hedone (pleasure), from hedys (sweet or pleasant).

Hedonistic theories of conduct have been held from the earliest times. They have been regularly misrepresented by their critics because of a simple misconception, namely, the assumption that the pleasure upheld by the hedonist is necessarily purely physical in its origins. This assumption is in most cases a complete perversion of the truth. Practically all hedonists recognize the existence of pleasures derived from fame and reputation, from friendship and sympathy, from knowledge and art. Most have urged that physical pleasures are not only ephemeral in themselves but also involve, either as prior conditions or as consequences, such pains as to discount any greater intensity that they may have while they last.

The earliest and most extreme form of hedonism is that of the Cyrenaics as stated by Aristippus, who argued that the goal of a good life should be the sentient pleasure of the moment. Since, as Protagoras maintained, knowledge is solely of momentary sensations, it is useless to try to calculate future pleasures and to balance pains against them. The true art of life is to crowd as much enjoyment as possible into each moment.

No school has been more subject to the misconception noted above than the Epicurean. Epicureanism is completely different from Cyrenaicism. For Epicurus pleasure was indeed the supreme good, but his interpretation of this maxim was profoundly influenced by the Socratic doctrine of prudence and Aristotles conception of the best life. The true hedonist would aim at a life of enduring pleasure, but this would be obtainable only under the guidance of reason. Self-control in the choice and limitation of pleasures with a view to reducing pain to a minimum was indispensable. This view informed the Epicurean maxim Of all this, the beginning, and the greatest good, is prudence. This negative side of Epicureanism developed to such an extent that some members of the school found the ideal life rather in indifference to pain than in positive enjoyment.

In the late 18th century Jeremy Bentham revived hedonism both as a psychological and as a moral theory under the umbrella of utilitarianism. Individuals have no goal other than the greatest pleasure, thus each person ought to pursue the greatest pleasure. It would seem to follow that each person inevitably always does what he or she ought. Bentham sought the solution to this paradox on different occasions in two incompatible directions. Sometimes he says that the act which one does is the act which one thinks will give the most pleasure, whereas the act which one ought to do is the act which really will provide the most pleasure. In short, calculation is salvation, while sin is shortsightedness. Alternatively he suggests that the act which one does is that which will give one the most pleasure, whereas the act one ought to do is that which will give all those affected by it the most pleasure.

The psychological doctrine that a humans only aim is pleasure was effectively attacked by Joseph Butler. He pointed out that each desire has its own specific object and that pleasure comes as a welcome addition or bonus when the desire achieves its object. Hence the paradox that the best way to get pleasure is to forget it and to pursue wholeheartedly other objects. Butler, however, went too far in maintaining that pleasure cannot be pursued as an end. Normally, indeed, when one is hungry or curious or lonely, there is desire to eat, to know, or to have company. These are not desires for pleasure. One can also eat sweets when one is not hungry, for the sake of the pleasure that they give.

Moral hedonism has been attacked since Socrates, though moralists sometimes have gone to the extreme of holding that humans never have a duty to bring about pleasure. It may seem odd to say that a human has a duty to pursue pleasure, but the pleasures of others certainly seem to count among the factors relevant in making a moral decision. One particular criticism which may be added to those usually urged against hedonists is that whereas they claim to simplify ethical problems by introducing a single standard, namely pleasure, in fact they have a double standard. As Bentham said, Nature has placed mankind under the governance of two sovereign masters, pain and pleasure. Hedonists tend to treat pleasure and pain as if they were, like heat and cold, degrees on a single scale, when they are really different in kind.

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Hedonism | Philosophy & Definition | Britannica