Inhibiting Key Molecular Chaperone Sensitives Tumors to Radiation Therapy in Animal Models – University of Michigan Health System News

The molecular chaperone protein known as heat shock protein 90 (Hsp90) helps stabilize a number of proteins that are involved in tumor growth. This is why inhibitors that act on the protein have been investigated as potential anti-cancer drugs.

So far, however, the inhibitors developed by various academic groups and pharmaceutical companies have met with limited success due to their high toxicity to normal cells.

Now, a new animal model study from the University of Michigan Rogel Cancer Center suggests Hsp90 inhibitors could help treat cancer in an indirect way. A low dose of a Hsp90 inhibitor known as AT13387 (onalespib) was able to sensitize tumors to radiation therapy, according to findings published in Clinical Cancer Research.

To the best of our knowledge, our study is the first to demonstrate that a sub-cytotoxic concentration of an Hsp90 inhibitor can inhibit the DNA repair process and thus selectively sensitize tumors to radiotherapy, says study senior author Mukesh Nyati, Ph.D., an associate professor of radiation oncology at Michigan Medicine.

The approach led to significant reduction in tumor growth in mouse xenograft models of head and neck squamous cell carcinoma and pancreatic cancer.

The Hsp90 inhibitor compound used in the study was provided by the Cancer Therapy Evaluation Program at the National Institutes of Health.

Paper cited: Low dose Hsp90 inhibitor selectively radiosensitizes HNSCC and Pancreatic xenografts, Clinical Cancer Research. DOI: 10.1158/1078-0432.CCR-19-3102

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Inhibiting Key Molecular Chaperone Sensitives Tumors to Radiation Therapy in Animal Models - University of Michigan Health System News

Bill Kemp: Forget Whos on first, whos gonna catch it? – The Ledger

Some teams have resorted to utilizing cardboard cutouts of fans. Expect an army of Teddy bears, mannequins and mask-clad puppets marching up the outfield ramp soon.

The stands look like those of a last-place team in September.

With no fans in the seats at major league baseball games, home run balls just clang around in the empty seats before disappearing underneath one. Actually, it looks like giant a pinball machine out there with no one commanding the flippers.

"Tommy can you hear me?"

What a lonely baseball.

The late Detroit Tigers Hall of Fame play-by-play radio announcer Ernie Harwell used to proclaim, "A man from Kalamazoo caught that one," after a foul ball lofted into the jam-packed stands. And it sounded believable to young listeners, whom scratched their heads and wondered, "How did he know that?"

Some teams have resorted to utilizing cardboard cutouts of fans in a stark attempt to create ballpark spirit while missing the aroma of hot dogs, peanuts and liquid libations aiding their cause. Expect an army of Teddy bears, mannequins and mask-clad puppets marching up the outfield ramp real soon.

Maybe franchises could glue gloves onto those cutouts. If the ball bounces or pops in, it belongs to the lucky fan who bank-rolled the knock-off.

Companies might consider purchasing corporate sponsorship boxes and send 20 fortunate employee cutouts clad with its company logo to the game.

How about some famous fans cutouts like Bill Murray, Drew Carey, Tom Selleck and Jerry Seinfeld? Or Eminen and some rock groups to liven up luxury boxes? An Erin Andrews cutout with piped in audio could ask them some baseball trivia during a pitching change.

We need something, because when a historic blast happens, someone or something needs to field it. The fans snag and story is just as intrinsic to the event as well.

Los Angeles Angels first baseman Albert Pujols is just four home runs shy of catching Willie Mays with 660 and moving into fifth place on the all-time home run list. Barring injury or some COVID-crud, this is going down real soon.

So whos gonna catch it unless it leaves the park?

When Babe Ruth entered immortality with his 700th career blast at Navin Field in Detroit, at least 17-year-old Lenny Bielski ran it down and dove underneath a parked car to claim it. According to a 1973 Detroit Free Press interview, Bielski reminisced about the mob which immediately pursued.

"Then a lot of policemen and ushers all grabbed me. They put me on their shoulders and stopped the game and took me into the ballpark and put me in the dugout with Babe Ruth, Joe McCarthy the manager and Lou Gehrig. After the game Babe said, Im gonna give him $120. He didnt have his wallet, though, so he told Gehrig, Ill give that boy a $20 bill,'" said Bielski in the interview.

Did that moment and not-so-lonely ball mean something to him and Ruth? Well, he never spent the $20 even though it was during hub of the Great Depression.

Tigers first baseman Miguel Cabrera just passed Adrian Beltre with a home run Saturday and is 22 round-trippers shy of the exclusive 500 club. He may not have a legitimate shot at 22 on a 60-game schedule, but he needs just 15 more to catch Gehrig and Fred McGriff -- tied for 28th place on the all-time list with 493. Historically, Cabrera bashes one every 18.76 at-bats.

If Miggy hits it, someone has to fetch it, and Bielski doesnt live in the neighborhood anymore.

Maybe they could put a corporate-sponsored cardboard cutout of the Beatles out there dressed in Dr. Peppers Lonely Balls Club fans attire to get a glove on it.

Bill Kemp can be reached at Bill.Kemp@theledger.com; follow him on Twitter @BillKempSports

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Bill Kemp: Forget Whos on first, whos gonna catch it? - The Ledger

Haggerty: Rask’s legacy will very much be impacted by this playoff run – NBC Sports Boston

Its no stretch to say that a great deal of Tuukka Rasks ultimate legacy with the Bruins is tied up in the unprecedented 2020 Stanley Cup playoffs inside the bubble.

Sure, the 33-year-old is a Vezina Trophy finalist this season for the second time in his NHL career and is essentially in a two-man race with Winnipegs Connor Hellebuyck for the ultimate piece of goaltending hardware this season. The .929 save percentage and NHL-leading 2.25 goals against average speak for themselves about his dominance this year while largely splitting time with backup goalie Jaroslav Halak in a nearly equal split of playing time.

Truthfully, the regular season accolades go on and on for Rask as he continues to prove hes the best regular season goaltender in Bruins franchise history. Hes the all-time winningest goalie in Bruins history with 291 wins, and has the most games played (536), the most saves (13,711) and the best save percentage (.922) in the Bs nearly 100-year franchise history.

Get the latest news and analysis on all of your teams from NBC Sports Bostonby downloading the My Teams App

Even his playoff stats are excellent as Rask ranks seventh all-time in NHL history with a .9268 save percentage in the postseason and is the active leader among all NHL goalies with a .9218 career save percentage in the regular season over his 13-year career.

He ranks third all-time in career save percentage behindDominik Hasek and Johnny Bower, both Hall of Famers. Clearly, the reduced workload paired with Jaroslav Halak has been a big deal to Rask in the last couple of seasons as hes approaching his mid-thirties. The reduced workload led directly to playing at a Vezina Trophy level all season and allowed Rask to carry the Bruins with a .934 save percentage during last springs run to the Stanley Cup Final.

Rask is even beginning to push his way into the Hockey Hall of Fame conversation as the career numbers pile up for him.

But there is an unfinished business element to his decade-long legacy with the Black and Gold after falling short in some extremely big moments for the Bruins during the postseason.

You look at as a process and when youre a young guy, youre just looking to make a name for yourself, said Rask. And then as the years go by you kind of learn different things about your game and about yourself, and what you need to do and what not [to do].

In the years where I needed to play a lot of games I had to focus on keeping my mind sharp and my body rested, and years where I didnt have to play a lot of games then you have more practice time. I think over the years its a balance of keeping your mind and body in sync. And you try to improve your game every day and every year and then before you know it ten years have gone by. You say wow and its been a long time when it doesnt feel like its been that long.

Rask has won a Stanley Cup as a backup to Tim Thomas in 2011, but the Finnish netminder has not been able to carry the Bruins to hockey immortality as the franchise guy. He has yet to get the Bs over the top in two tries at the Stanley Cup Final in 2013 and 2019 and the Bruins enter this postseason as the favorites after winning the Presidents'Trophy during the regular season.

If you look at the way our team is built, were built for a long run into the playoffs, said Rask. Unfortunately, we were heading to a direction when the league, and the whole world, came to a stop. Now we have to go back to building that chemistry with the same group as when it stopped. Obviously, winning a Stanley Cup or any trophy in Boston is a big thing.

Thats something we need to try for and thats our goal. We just have to adapt and build that groove and chemistry back up. The way I look at it is that all bets are off because everybody has been off for the last four months and were starting from scratch.

The Bruins' core group isnt getting any younger and neither is Rask as he enters the final year of his contract with Boston next season, so this may be the last, best chance for all of them to win one more before the championship window begins to close.

If Rask once again falls short this postseason, fair or not, it will cement a legacy that he was never able to carry the Bruins over the Cup threshold as Tim Thomas did almost 10 years ago when he pitched shutouts in Game 7 of both the Eastern Conference Final and then again in the Stanley Cup Final against the Vancouver Canucks. If he's not ready to play after the long layoff and the Bruins exit the postseason quickly, it will be even worse for all parties involved.

If Rask is able to play as he did last postseason, when he would have won the Conn Smythe Trophy had the Bs won Game 7 against St. Louis, and finish it off by playing well when the Bruins need him most in a Game 7-type situation, then it will be the crowning achievement in whats already been an exceptional regular season career. It could mean entry to the Hockey Hall of Fame for Rask, and it certainly would clinch his status as the best goalie in the nearly 100-year history of the Bruins franchise.

But all of it comes down to how things go for the goaltender and the Bs hockey club that takes many of its cues from exactly how he is playing between the pipes.

So, yeah, theres quite a bit riding on how things go for Rask in his go-round for the Bruins in the Stanley Cup playoffs.

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Haggerty: Rask's legacy will very much be impacted by this playoff run - NBC Sports Boston

From Alissons assist to Origi lobbing Pickford Every Liverpool players best moment of 2019/20 – This Is Anfield

Liverpool sealed immortality in 2019/20, finally winning the Premier League title. But what was each players standout contribution to the season?

Last August, the Reds went into the new campaign as Champions League holders, but the holy grail of a league title had evaded them once more.

What we have witnessed in the 11 months since has been truly remarkable, with 99 points amassed and a worldwide pandemic halting Liverpools title charge for nearly three months.

Jurgen Klopp and his players have gained legendary status forever, with so many individuals coming up with the goods at different times.

Heres what we think was each Liverpool players best moment of 2019/20.

(NB: Excludes those to have made fewer than 10 appearances in all competitions, which rules out the likes of Harvey Elliott, Caoimhin Kelleher and Andy Lonergan.)

Alissons assist against Man United was a standout moment of the entire campaign, as he fired an inch-perfect pass to the onrushing Mohamed Salah.

The Brazilian then raced the full length of the pitch for good measure, producing a world-class knee slide as he celebrated with his team-mate.

Adrian has had an up-and-down first season at Liverpool, but he contributed greatly in the UEFA Super Cup.

The Spaniard saved Tammy Abrahams must-score penalty in the shootout win over Chelsea, sealing yet another trophy for the Reds.

Trent Alexander-Arnolds meteoric rise continued in 2019/20, as he cemented his reputation as one of world footballs most exciting young players.

His performance at Leicester on Boxing Day was arguably the best individual display of the season, with a goal, two assists and a clean sheet to his name.

Neco Williams has come of age this season and he now looks an able deputy to Alexander-Arnold.

The teenager made his Premier League debut against Crystal Palace in Junean immensely proud moment for a huge talent.

Joe Gomez is very much Virgil van Dijks junior partner at the heart of Liverpools defence, but he became the leader in the FA Cup clash with Everton.

He was magnificent in the 1-0 over the Blues, performing immaculately alongside the inexperienced Nat Phillips.

Van Dijk has repeated last seasons brilliance, becoming an ever-present in the Premier League for a second season in a row.

The Dutchmans header at home to United has to be his best moment, although his incredible headed control to himself against Brighton epitomised his class.

Injuries have again disrupted Joel Matips season, but he was in imperious form at the start of the campaign.

The centre-backs bullet header at home to Arsenal in August set Liverpool on their way to a resounding 3-1 victory.

Lovren leaves Anfield this summer and his season was often miss rather than hit.

Thats not to say there havent been key contributions, however, not least in the 3-1 win over Man City at Anfield, when he was a rock at the back.

His brilliant assist against Chelsea comes close, but Andy Robertsons equaliser at Aston Villa in November was a big moment in the season.

Without his header, and the Sadio Mane strike that followed, the title race could so easily have panned out differently on a day when City looked to have narrowed the gap to just four points.

The win over City was a day that highlighted Liverpools superiority over their rivals and Fabinho was a monster in the middle of the park.

The Brazilians stunning strike opened the scoring he would score a similar effort at home to Palace, too.

Theres only one winner here.

Jordan Henderson became the first-ever Liverpool captain to lift the Premier League trophy it is an image that he will be remembered for forever.

That Steven Gerrard-shaped shadow looming over him is no more.

It might not have been pretty, but Gini Wijnaldums winner at Sheffield United was priceless.

The 29-year-olds volley squeezed through the hands of Dean Henderson to send the away end wild, as Liverpool maintained their 100 percent record in gritty fashion.

When it comes to scoring a penalty, would you trust anyone more than James Milner?

The veterans last-gasp spot-kick against Leicester at Anfield was another enormous moment in the title race, as Liverpools relentless march to glory continued.

Naby Keita has been one of Liverpools star men after the restart, having blown hot and cold prior to it.

The Guineans thunderous strike against Chelsea was his best goal yet for the Reds and further suggests he is on the verge of becoming an increasingly key figure.

Alex Oxlade-Chamberlain chipped in with eight goals in 2019/20, including a beauty against former club Arsenal in the League Cup.

It was his gorgeous outside-of-the-foot finish away to Genk that was the pick of the bunch, though, with the shot hitting the underside of the crossbar for good measure.

Adam Lallana departs Liverpool as a hugely popular figure, with his impact off the pitch valued greatly by Klopp.

His late equaliser away to United was crucial in its own right, however, preserving the Reds unbeaten record at the time.

This is an obvious one, isnt it?

Scoring in the Premier League against Villa was a great moment for Curtis Jones, as was netting the winning penalty in front of the Kop against Arsenal in the League Cup.

But both pale into insignificance compared to bagging a brilliant winner at home to Everton in the FA Cup.

A dream moment for any boyhood Red.

Xherdan Shaqiris influence at Liverpool has steadily dwindled, but he has still chipped in sporadically.

The Swiss slid home a lovely finish against Everton in the league, on a night when he was at his unpredictable, entertaining best.

Takumi Minamino has yet to make a noticeable contribution for Liverpool, so we will go with his outstanding performance for Salzburg at Anfield.

It was one of the best displays by an opposition player in years, including a well-taken volley.

The 2-0 win over United felt like the day the title was clinched and Salahs aforementioned goal was the crowning moment of the match.

He latched onto Alissons long pass in supreme fashion, before finishing well past David De Gea in front of an ecstatic Kop.

The celebration wasnt too shabby, either.

Mane is a strong Player of the Year contender, producing so many major contributions along the way.

It is his stoppage-time winner at Villa that will arguably be remembered as Liverpools biggest goal of the season, however, with the Senegalese steering a header into the far corner.

It may not have been the most ruthless season of Roberto Firminos career, but he still scored the goal that clinched the Club World Cup back in December.

The 28-year-old finishing with aplomb in the 1-0 win over Flamengo, further etching his name into Liverpool folklore.

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From Alissons assist to Origi lobbing Pickford Every Liverpool players best moment of 2019/20 - This Is Anfield

The dismissible – The News International

The dismissible

When an event is unexplained, it cant be repeated. Cubas astonishing internationalism, the good news of the pandemic, is talked about (outside Cuba) as if a miracle, without cause. Support grows for the Nobel Prize nomination but the justification for the Henry Reeve Brigade, established in 2005, is left out. The explanation is ideas.

It is urgent according to Eddie Glaude in a new book on James Baldwin. Well, he doesnt exactly say that. But for Baldwin, what kind of human beings we aspire to be is most important and the explanation for Cubas success is precisely that. In Zona Roja, Enrique Ubieta Gmez says Cuban medical workers fighting Ebola in 2014 know about existence: We exist interdependently. Ubieta describes Cuban internationalism as an inescapable ethic. Once youve lived it, you cannot not live it. You know human connection a fact of science and you learn its energy.

Ubietas explanation is existential. Baldwin used similar language. In 1963, he wrote, Perhaps the whole root of our trouble, the human trouble, is that we imprison ourselves to deny the fact of death, which is the only fact we have. Glaude supports Baldwins call to begin again, with the America idea, shedding its old ideas. He might look South. Latin American independistas raised precisely Baldwins question: how to resist the lie at the heart of the [imperialist] nation when it is about love, life and death, that is, everything.

Truth is not enough. If Galileo had just provided truths, he wouldnt have been condemned. Galileo became threatening when he made those truths plausible with a larger picture of cosmic humility, contradicting the establishments comforting identity. One thing we might learn from Galileo, according to astrophysicist Mario Livio in a new book, is that he didnt just observe truths and tell stories about them. His phenomenal capacity for abstraction let him see where those truths led.

Truths are easy when unexplained. Consider Olga Tokarczuks 'Flights'. It gives truth about people traveling everywhere escaping their own lives, and then being safely escorted right back to them. We see people running through airports with flushed red faces, their straw hats and souvenir drums and masks and shell necklaces. All this moving around in a chaotic fashion [to] increase their likelihood of being in the right place at the right time even has meaning. A travel psychologist explains that such chaos appears to call into question the existence of a self understood non-relationally.

It is funny to expect deeper meaning regarding people moving around in a chaotic fashion to increase their likelihood of being in the right place at the right time from a travel psychologist at an airport between flights. We laugh because we do in fact expect that, absurdly.

We get truth from 'Flights' but its dismissible. Annushka, for instance, escapes her unbearable life : to go, sway, walk, run, take flight. She finds happiness when she does not have a single thought in her head, a single care, a single expectation or hope. Shes happy, free of her identity, her life, her responsibilities. But she is also cold, hungry, dirty, alone, tired, and homeless. The image is silly.

In fact, the idea underlying it is silly, namely, that to have no thoughts, you should have no identity, no responsibilities. Its as pervasive as friction, from which Galileo abstracted to get truth about inertia. In fact, to be happy with no expectations or hope, as Annushka is, is not silly. But understanding how that is so requires a phenomenal capacity for abstraction from social expectations.

'Flights' doesnt do that. It responds to an expectation identified by Cuban philosopher and diplomat Raul Roa in 1953 as the worlds gravest crisis. It was indeed the America idea: Human beings imprisoned in discrete selves, defined by action and results. It is not humanist, as claimed, Roa argues, because it omits the fact of death, as Baldwin recognized. There were few dissenters to the man of action during the Renaissance, and Roa saw there would now be none because of US power.

Baldwin tried to escape that power by living outside the US. He struggled with what it had made of him. But American power follows one everywhere.

Emily Dickinson, the greatest poet in the English language, abstracts from expectations 'Flights' dignifies. According to biographer Martha Ackman, Dickinson lived as if busyness and travel is not progress. She never apologized for, nor defended, the priority she gave to silence and solitude. As result, we get truth from her poetry: about what it means to be human. For, she was in fact not detached from a world she never visited physically or had any desire to.

She lived as if isolation and detachment are not synonymous. But to know where this leads, you must abstract from the America idea that equates human worth and utility. Comfortably, though, Dickinson is odd Americas most enigmatic and mysterious poet and her way of life therefore dismissible.

'Lord of all the Dead', like 'Flights', leaves comforting old ideas in place. Javier Cercas tells the story of his great-uncle who fought a useless war for Franko. His memoire does give truth but doesnt explain it, so his story, which for him is just a story, cannot itself explain, and is dismissible.

Achilles in 'The Odyssey' is lord of all the dead because he died young and beautiful, and gained immortality. That his great uncle was politically mistaken, theres no doubt. But was he a human failure? Cercas answer is no. At one level, Cercas rejects the Greeks ideal of beautiful death because it denies the existential reality of decrepitude: There is no escaping it. But on the other hand, Cercas assumes the separation of mind and body that makes beautiful death worth speculating about: the idea that the body decays and that the mind somehow escapes natures universal laws of causation.

He ends the book speculating about immortality. Nobody dies, he writes. Were just transformed, physically. He himself, at the book's end, is in the eternal present. It doesnt explain what needs to be explained, given the real story of this book which is what Cercas calls the silent wake of hatred, resentment and violence left over by the war. The silent wake is explained by ignorance precisely of shared humanity Cercas names but doesnt explain. It is decrepitude: the fact of death.

It is known by every human being. Cercas tells a story about his great uncle but denies the significance of that story because he tells it with the old ideas in place, the ones Glaude says need to be shed, like swaddling clothes to begin again as Baldwin urged. Glaude is not sure it can happen. But it has happened. Thats the good news about the Henry Reeve Medical brigade, if it were explained.

On Friday, March 20, Cuban president, Miguel Diaz-Canel, speaking nationally, outlined new measures to slow the pandemic. The good news, he said, is that Cuban people supported the decision to accept the Braemar, a UK cruise ship refused docking elsewhere because of infected passengers. A century ago, another ship sought aid from Cuba. Its passengers were Jews. It was turned away.

That, Diaz-Canel said, was before the Revolution. The good news was the expectation that the Braemar should be helped. That expectation is the success of the Cuban revolution. It explains the Henry Reeve Brigade. Expectations come from practises, from what is lived. Diaz-Canel then said, one day the truth will be known. But what truth?

Excerpted from: 'Cubas Nobel Nomination and Baldwins Call to Begin Again'.

Courtesy: Counterpunch.org

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The dismissible - The News International

Sacred Islands Of Exotic Eastern Gods And Elixir Of The Immortals – Ancient Origins

Classic works such as Odyssey by Homer, The Tempest by William Shakespeare and Robinson Crusoe by Daniel Defoe tell about mysterious distant islands. These islands are usually exotic and inaccessible homes to treasures, spirits and immortals - providing the heroes with many strange adventures. From at least the third century BC, the Chinese culture regarded islands as sacred homes to the elixir of immortality. All these enticements then inspired a trend of voyages in search of sacred islands.

The early history of the quests in search of the sacred islands to gain immortality came to dominate imperial Chinese folklore of islands and the ocean. The narrative style of these quests first developed in the Ancient Chinese Classic of Mountains and Seas , acompilation of Chinese mythology, mythical geographyand cultural account of pre-QinChina.As Chinas maritime activity increased, fictions about islands of adventure gained popularity. This trend, in turn, inspired another trend of constructing artificial islands in imperial palace gardens.

Mount Penglai (Mountain of Immortals) by Tomioka Tessai (1924) ( Public Domain )

An influential fourth century BC Chinesephilosopher, Zhuang Zhou, tells of the immortals. The immortals are perfect beings who dwell in faraway islands, celebrated in poetry and paintings for their beauty and bountiful nature.

These islands became a favorite subject of Chinese and Japanese landscape painting. They had neither winter nor misery. However, they had high mountains, lush vegetation, clear blue waters as well as beautiful flora and fauna. The plants in these islands had magical qualities such as restoring youth and offering immortality to those who consume them. Other magical richness included waters of life, life-prolonging trees and enchanted fruits that can heal any ailment, grant eternal youth and even raise the dead.

The three most famous islands in Qin and Han Dynasty literary works are Penglai, Fangzhang and Yingzhou. Reports of these three sacred islands first appear in the late second centuryBC Taishi Official Book , better known as Records of the Grand Historian in which King Wei, King Xuan of Qi State, and King Zhao of Yan State sent their officials to look for the three sacred islands - Penglai, Fangzhang, and Yingzhou.

Penglai (detail), depiction of one of the mythical islands by Yuan Yao (18th century) ( Public Domain )

Seen from afar, the islands are covered in clouds. When regular people approached these islands, a disastrous wind would hit and force the boat to leave

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Martini Fisher is a Mythographer and author of many books, including Time Maps: Gods, Kings and Prophets | Check out MartiniFisher.com

Top Image : A 19th century ukiyo-e by Kuniyoshi depicting the ships of the great sea expedition sent around 219 BC by the first Chinese Emperor, Qin Shi Huang, to find the legendary home of the immortals, the Mount Penglai, and retrieve the elixir of immortality. ( Public Domain)

ByMartini Fisher

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Sacred Islands Of Exotic Eastern Gods And Elixir Of The Immortals - Ancient Origins

Hack job? What’s the deal with David Pastrnak’s latest tweet? – NBC Sports Boston

Its no stretch to say that a great deal of Tuukka Rasks ultimate legacy with the Bruins is tied up in the unprecedented 2020 Stanley Cup playoffs inside the bubble.

Sure, the 33-year-old is a Vezina Trophy finalist this season for the second time in his NHL career and is essentially in a two-man race with Winnipegs Connor Hellebuyck for the ultimate piece of goaltending hardware this season. The .929 save percentage and NHL-leading 2.25 goals against average speak for themselves about his dominance this year while largely splitting time with backup goalie Jaroslav Halak in a nearly equal split of playing time.

Truthfully, the regular season accolades go on and on for Rask as he continues to prove hes the best regular season goaltender in Bruins franchise history. Hes the all-time winningest goalie in Bruins history with 291 wins, and has the most games played (536), the most saves (13,711) and the best save percentage (.922) in the Bs nearly 100-year franchise history.

Get the latest news and analysis on all of your teams from NBC Sports Bostonby downloading the My Teams App

Even his playoff stats are excellent as Rask ranks seventh all-time in NHL history with a .9268 save percentage in the postseason and is the active leader among all NHL goalies with a .9218 career save percentage in the regular season over his 13-year career.

He ranks third all-time in career save percentage behindDominik Hasek and Johnny Bower, both Hall of Famers. Clearly, the reduced workload paired with Jaroslav Halak has been a big deal to Rask in the last couple of seasons as hes approaching his mid-thirties. The reduced workload led directly to playing at a Vezina Trophy level all season and allowed Rask to carry the Bruins with a .934 save percentage during last springs run to the Stanley Cup Final.

Rask is even beginning to push his way into the Hockey Hall of Fame conversation as the career numbers pile up for him.

But there is an unfinished business element to his decade-long legacy with the Black and Gold after falling short in some extremely big moments for the Bruins during the postseason.

You look at as a process and when youre a young guy, youre just looking to make a name for yourself, said Rask. And then as the years go by you kind of learn different things about your game and about yourself, and what you need to do and what not [to do].

In the years where I needed to play a lot of games I had to focus on keeping my mind sharp and my body rested, and years where I didnt have to play a lot of games then you have more practice time. I think over the years its a balance of keeping your mind and body in sync. And you try to improve your game every day and every year and then before you know it ten years have gone by. You say wow and its been a long time when it doesnt feel like its been that long.

Rask has won a Stanley Cup as a backup to Tim Thomas in 2011, but the Finnish netminder has not been able to carry the Bruins to hockey immortality as the franchise guy. He has yet to get the Bs over the top in two tries at the Stanley Cup Final in 2013 and 2019 and the Bruins enter this postseason as the favorites after winning the Presidents'Trophy during the regular season.

If you look at the way our team is built, were built for a long run into the playoffs, said Rask. Unfortunately, we were heading to a direction when the league, and the whole world, came to a stop. Now we have to go back to building that chemistry with the same group as when it stopped. Obviously, winning a Stanley Cup or any trophy in Boston is a big thing.

Thats something we need to try for and thats our goal. We just have to adapt and build that groove and chemistry back up. The way I look at it is that all bets are off because everybody has been off for the last four months and were starting from scratch.

The Bruins' core group isnt getting any younger and neither is Rask as he enters the final year of his contract with Boston next season, so this may be the last, best chance for all of them to win one more before the championship window begins to close.

If Rask once again falls short this postseason, fair or not, it will cement a legacy that he was never able to carry the Bruins over the Cup threshold as Tim Thomas did almost 10 years ago when he pitched shutouts in Game 7 of both the Eastern Conference Final and then again in the Stanley Cup Final against the Vancouver Canucks. If he's not ready to play after the long layoff and the Bruins exit the postseason quickly, it will be even worse for all parties involved.

If Rask is able to play as he did last postseason, when he would have won the Conn Smythe Trophy had the Bs won Game 7 against St. Louis, and finish it off by playing well when the Bruins need him most in a Game 7-type situation, then it will be the crowning achievement in whats already been an exceptional regular season career. It could mean entry to the Hockey Hall of Fame for Rask, and it certainly would clinch his status as the best goalie in the nearly 100-year history of the Bruins franchise.

But all of it comes down to how things go for the goaltender and the Bs hockey club that takes many of its cues from exactly how he is playing between the pipes.

So, yeah, theres quite a bit riding on how things go for Rask in his go-round for the Bruins in the Stanley Cup playoffs.

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Hack job? What's the deal with David Pastrnak's latest tweet? - NBC Sports Boston

Peaches are now in season; here’s a recipe to enjoy the fruit with a savory salad – Fly Magazine

A ripe peach tender to the touch, floral and honeyed in the nose, slurpy on first bite is a sensory experience like few others. And that river of nectar flooding the tongue? For a few minutes, I am a hummingbird in flight, buzzing with unbridled joy.

If you can relate, then you know that the way to eat a peach in unadulterated bliss is over the sink just you and the peach having a moment with the juices running down your arms and the faucet at the ready for clean-up duty.

For many a peach lover, baking cobbler, churning ice cream and putting up jam are summertime traditions. Personally, I find the peach so teeth-tingling sweet in its natural state that I crave little adornment. Unless, of course, were going savory.

In fact, that inherent sweetness plays well with big and bold flavors typically reserved for the savory world including fresh basil and mint, chile peppers, onions and ginger root. Peaches like the smoke of charcoal and enjoy being grilled themselves or paired with grilled chicken, pork or shrimp.

Just days ago, I got to see for myself just how far savory I could take the sweet peach. Inspiration came while leafing through my dog-eared copy of Ripe, an ode to fruit by British food writer Nigel Slater.

In his essay on peaches, Slater shares, in his signature notebook style, a recipe for a peach-forward salad amped up with bold and beautiful basil and mint, sweet peppers and a kicky Viet-style dressing of fish sauce, limes and chile peppers.

Slater calls for shredded chicken, which is delightful, but if chicken is neither interesting nor available, the salad will still be a riot of color and flavor. Its that good.

As I built the salad, I added cucumber, a few cherry tomatoes and raw peanuts, along with some backyard romaine to line our plates. My husband envisions a side of rice or rice noodles for the next time. And as long as peaches are gracing farmstand shelves, there will definitely be a next time.

A salad of peaches and herbs (and maybe chicken) with a Viet-style dressing

Adapted from Ripe by Nigel Slater.

Makes 4 servings.

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Preheat the oven to 400 F.

In a small bowl, stir together the spices and oil, and rub all over the chicken. Place on a sheet pan or in a baking dish and roast until golden and cooked through, about 30 minutes. (This step can also be done on the grill and can be done in advance.) Remove the oven and let cool while you prep the rest of the salad.

Make the dressing: In a small bowl, stir together the fish sauce, lime and sugar with a fork until the sugar is dissolved. Add the chile pepper and scallions, stir and set aside under ready to serve. The flavors deepen as the dressing sits.

Slice the peaches in half, remove the pits and cut into 1/2-inch slices. Transfer to a large bowl. Add the pepper strips and the herbs. Resist the urge to stir.

Shred or thinly slice the chicken off the bone and add to the peach mixture. Add any of the optional add-ons and gently stir until evenly distributed.

When ready to serve, gradually add half of the dressing, stirring until well coated.

If using the lettuce, lay on a platter or on the bottom of a bowl, then place salad on top. Sprinkle with peanuts, if using, and bring the remaining dressing to the table.

The peach is an ancient Chinese relic, dating to fifth century B.C. when it was mentioned throughout a collection of poetry by Confucius. The peach was highly revered and continues to play an important role in the folklore of the Chinese people. Known as tao, the peach is the most

sacred plant of the Chinese Taoists, and is considered a magic fruit and a symbol of immortality, reflected in the Peach Blossom Spring, an essay by a Chinese poet during the fourth century B.C.

From China, the peach traveled to Persia and then onto Greece, and into the rest of Europe, thanks to peach lover Alexander the Great.

The peach came to Mexico in the early to mid-1500s via Spanish explorers. Throughout the 1600s, the peach traveled north from coastal Georgia and north Florida and was cultivated in the colonies of Virginia, Maryland and New Jersey.

First things first: Inhale (with social distancing in mind, of course). If you don't catch a whiff of that signature perfume, move on to the next peach. A ready-to-eat peach should be fragrant and invite you in.

For immediate consumption, choose fruit that has some tactile give, (similar to the fleshy part of your palm), but also that is free of bruises and boo-boos. On the other hand, if a peach is rock hard, it probably has been picked too early often the case for long-distance fruit and should be left behind.

Even for less-than-perfectly-ripe fruit, carefully transport your precious cargo home because it is highly perishable. I remember from my days working a fruit stand how wed have to pay special attention to the peaches on hot days to make sure they did not grow moldy beards.

Once home, keep peaches out of the refrigerator and out of direct sunlight. On the other hand, to buy some time for a ripe peach, stick it in the refrigerator, where it stops ripening. Caveat: Refrigeration invites moisture and shriveling.

Although tempting to place several almost-ripe peaches in a pretty bowl, keep in mind that they can mold even if rubbing up against each other.

Freeze for later

If peach season feels too short, consider freezing a bunch for later. Unlike berries, which can be frozen individually, peaches need a little more processing before the deep freeze. Drop the fruit into boiling water for about 45 seconds then into a bowl of ice water. This helps ease peeling, which is recommended. Once cool, slice in half and remove the pit. Cut each half into two or three pieces and place on a sheet pan to dry. Drizzle a small amount of fresh lemon juice on top and place in freezer until solid. Pack in freezer-safe containers or bags.

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Peaches are now in season; here's a recipe to enjoy the fruit with a savory salad - Fly Magazine

MCU Phase 4 Theory: Character Who Connects WandaVision To Doctor Strange 2 – Screen Rant

Kathryn Hahn is playing a "nosy neighbor" in WandaVision - could she be Agatha Harkness, a link to Doctor Strange in the Multiverse of Madness?

Kathryn Hahnwill play an important role inWandaVision - and she could help link the upcoming Disney+ series toDoctor Strange in the Multiverse of Madness. The future has never looked brighter for Elizabeth Olsen's Scarlet Witch; not only is she co-star of her own Disney+ limited series, but this will set her up for a major role inDoctor Strange 2 as well.

Ever secretive, Marvel is keeping their plans for Scarlet Witch under wraps. It's safe to assume the studio is imitating the comics by retconning Wanda as a sorceress, as hinted by Marvel Studios president Kevin Feige himself. But will Wanda be an ally of the future Sorcerer Supreme, or will she be the cause of the "Multiverse of Madness," her powers wreaking havoc as they did in the comics? Whatever Scarlet Witch's arc may be,WandaVision will set it up, so all attention is focused on the Disney+ show.

Related:The MCU's Doctor Strange Totally Wasted The Time Stone

Particular attention has focused onKathryn Hahn, who joined the cast ofWandaVision in an undisclosed role. She's confirmed to be playing a "nosy neighbor," which sounds tame until you remember the kind of seriesWandaVision appears to be riffing on. Nosy neighbors are a crucial, frequently antagonistic force in sitcoms and soap operas. That's led to intense speculationHahn could actually be playing Agatha Harkness, a key ally of Scarlet Witch in the comics, who is frequently at odds with Wanda but ultimately became her mentor.

In the comics, Agatha Harkness was one of Marvel's most powerful witches. She claimed to be old enough to remember the fall of Atlantis over 10,000 years ago, and gained immortality through forbidden magic. In more modern times, the ruthless witch moved to America, and was involved in the slaughter of witches in New Salem. In fact, she turned several of her sisters over to the authorities, currying their favor and claiming she was culling the weak. Agatha Harkness became a governess after the Second World War, and was introduced when she was hired to look after Franklin Richards, the son of Mr. Fantastic and the Invisible Woman. Since then, she's played a key role as a mentor for some of Marvel's most powerful young heroes, or for nascent witches like Wanda Maximoff. Her relationship with Wanda was frequently antagonistic, and in the end Scarlet Witch killed her. In a perfectly comic-book twist, Agatha's ghost currently haunts Wanda, serving as her advisor.

While her exact role is unconfirmed, set photos suggestHahn is indeed playing the MCU's Agatha Harkness, but if so she'll probably be switched up a little; Marvel is unlikely to make her a near-immortal, for example, having already explored that trope with the Ancient One inDoctor Strange. More to the point, it's reasonable to assume Agatha wouldn't just be some random mystic, but rather would have strong ties to the magical community - perhaps meaning she had been trained by the Ancient One at Kamar-Taj. This means she could potentially serve as the bridge betweenWandaVision andDoctor Strange 2; the series could end with Wanda's magical potential revealed, and Agatha deciding to take her to Kamar-Taj for training. That plot would be a simple, organic one, and it would explain why Marvel hired such a notable actress to play a "nosy neighbor."

More:Doctor Strange 2: Every Theory About What Starts The Multiverse of Madness

Key Release Dates

The Mandalorian: Where Han Solo Is During The Events Of The Show

Tom Bacon is one of Screen Rant's staff writers, and he's frankly amused that his childhood is back - and this time it's cool. Tom's focus tends to be on the various superhero franchises, as well as Star Wars, Doctor Who, and Star Trek; he's also an avid comic book reader. Over the years, Tom has built a strong relationship with aspects of the various fan communities, and is a Moderator on some of Facebook's largest MCU and X-Men groups. Previously, he's written entertainment news and articles for Movie Pilot.A graduate of Edge Hill University in the United Kingdom, Tom is still strongly connected with his alma mater; in fact, in his spare time he's a voluntary chaplain there. He's heavily involved with his local church, and anyone who checks him out on Twitter will quickly learn that he's interested in British politics as well.

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MCU Phase 4 Theory: Character Who Connects WandaVision To Doctor Strange 2 - Screen Rant

From Camus’ ‘The Plague’ To Dylan’s ‘Rough And Rowdy Days,’ Sad Is The New Happy – WBUR

You know the old curse: May you live in interesting times.

As the pandemic rages, there seems to be an all-pervasive sense of sadness in the air. Americans are less happy than theyve been since happiness started to be measured, says New York Times columnistDavid Brooks.

It isnt just the one plague. Theres also a sense of dread about the political scene and the disorientation about how Americas overdue reckoning with racism and the legacy of slavery will play out. It seems almost impossible to live ones life outside of that troika of troubles these days.

Its not a cloud of doom, certainly, more a feeling of fraughtness. Is the trip to the grocery store a journey to COVID country? Will the 2020 election be a repeat of 2016 despite the polls? What is our proper response to the killing of George Floyd and the rise of Black Lives Matter?

But those are only the obvious sources of where we stand this summer. The existential grip on our senses and our place in the world is more pervasive and melancholy. On a personal level I feel it listening to Bob Dylans great new album, Rough and Rowdy Ways; reacting to deaths in my old Boston Globe family; reading the books on my nightstand, from Albert Camus The Plague to Ford Madox Fords The Good Soldier (which he wanted to call The Saddest Story); and, more obviously, watching the nightly news.

Yet none of this is crushing. In some way, its even inspiriting. Take "The Plague," speaking of existentialism and the pandemic. Although written in part as a post-war metaphor for the Nazis and their enablers in Vichy France, Camus always meant for it to speak to future generations.

Seems like he got his wish. There are the obvious parallels between the shutdown of the Algeriantown of Oran because of a rat-born virus and todays pandemic. Such as the line Stupidity has a knack of getting its way. Or the way Camus describes the war between the individualists and those who argue that the only way of defeating the plague is to realize that were all in this together, which President Trump acknowledgedafter months of denial.

Then theres Camus life-long rebellion against the silence of God. Just as prayer is useless in The Plague, religion is downright lethal against the amoral randomness of the pandemic. Gatherings for prayer, in fact, are among the most hard-hit in America and the world, regardless of religion.

The ineffectiveness of prayer could drive one to despair, particularly if one is a true believer, but the lessons for Camus are different. We have to forge our own meaning and morality rather than rely on puritanical religious bodies. Another lesson is that we need to recognize the front-line workers and scientists. Dr. Rieux in The Plague and Ed, a paramedic in the wrenching play "The Line" from the Public Theater, eschew the idea of heroism, but its Dr. Fauci, I mean Dr. Rieux, who proves to be the shaman of Oran. For all the sadness in the world, there is a resistance to plagues and self-aggrandizing politicians that is inspiring. You can say the same thing about how Black Lives Matter and #MeToo movements have turned tragedy into galvanized political action today.

The pandemic also has those of us of a certain age thinking about our own mortality. Three friends from the Boston Globe died during the pandemic, though none from the plague. (A great guy, Ron Hutson, did die of COVID-19, but I unfortunately didnt know him well.) I worked at the paper from 1971 to 2006 and copy editorsLouis Bell, Al Rossi and writerBob Levey defined what a fun, extended family the paper was when it operated on Morrissey Boulevard. Normally, a Globe funeral or memorial celebration turns into a kind of alumni/alumnae party with remembrances galore, often fueled by adult beverages.

I can imagine the gales of laughter about Bell sending a smoke bomb down on what was called the bunwarmer to his antagonists in the composing room; Rossi thinking he was sending an email about a coworker farting to a friend only to discover he had sent it to the wind-passer; and Levey telling jokes with the panache of Mort Sahl.

Still, theres something almost holy about remembering them by myself. They kind of encapsulate my 35 years at the Globe Bell driving me and my roommates home in the 70s where hed get stoned and often pass out on the couch; Rossi and me having a wild weekend in Las Vegas in the 80s; telling Levey a joke that made him roar in the 90s when we both made career changes and became critics in the Living Arts section, he with food and me with television. These memories are somehow dearer to me for thinking about them in confinement they define me as well as them. Obviously Im sad that theyre gone, but the smile on my face when I think of them is different than those gales of laughter at the memorial services that weren't to be.

And, of course, their deaths presage my mortality as well. Its hard not to think about that while readingJohn Williams "Stoner" or Joseph O'Connors "Shadowplay" as protagonists (including Bram Stoker in "Shadowplay") reflect on what their lives have amounted to or come down to. (Talk about sad, Stoker was not a literary success. "Dracula" rose from the dead 10 years after he died.)

Bob Dylans Rough and Rowdy Ways has mortality writ large from the opening lines Today and tomorrow, and yesterday, too/ The flowers are dyin like all things do to the final 17-minute "Murder Most Foul," ostensibly about the assassination of John Kennedy.

Almost every song speaks in stoical terms of loneliness, bitterness, sad guitars, dark days, killing frost, the age of the Antichrist and approaching death. Yet the whole album is both consolation and celebration. It is, among other things, a celebration of the Anglo-American 20th-century songbook, with Beethoven, Chopin and Liberace thrown in for good measure. Name a musical strain worth celebrating and its in Rough and Rowdy Ways, the title nodding Dylans head to Jimmie Rodgers and continuing through Frank Sinatra, Ella Fitzgerald, Elvis Presley, John Lee Hooker, Jimmy Reed, Etta James, Otis Redding, Ray Charles, Oscar Peterson and countless great jazz pianists, Sun Records, gospel, Leonard Cohen, Rick Nelson, the Everly Brothers, Rodgers & Hammerstein, the Beatles and the Stones and countless others. (The 21st-century songbook is for others to write, Dylan implied in a recent New York Times interview with Douglas Brinkley.)

Are Dylans references just name-dropping? No. Its a look back at his life, his life in song, the life of America in the 20th and 21st centuries and what lives they were and are. Hes a man of many muses and many moods, as he says in I Contain Multitudes. The influence of Walt Whitmans Leaves of Grass is everywhere in Rough and Rowdy Ways.

And like Whitman hes also a man of contradictions. Some observers have said that the album sounds like a farewell, but as one critic observed in the 1970s, many of his songs are suitable for both funerals and weddings. Like Camus and his Dr. Rieux, Dylan has to embrace the sadness of his days in order to come out the other side in a search for meaning and a kind of immortality.

As he sings in I Contain Multitudes:

I go right to the edge, I go right to the endI go right to where all things lost are made good again.

So for all the sadness and intimations of mortality that he faces in Rough and Rowdy Ways, there is a full embrace of life in all its melancholy and all its merriment.

Robert F. Kennedy makes a cameo in Murder Most Foul. RFK has been cited as the person who popularized the "interesting times" quote, in a 1966 address in South Africa: There is a Chinese curse which says 'May he live in interesting times.' Like it or not, we live in interesting times. They are times of danger and uncertainty; but they are also more open to the creative energy of men than any other time in history.

Though South Africa was still in the grip of apartheid, Kennedy delivered the plea to end discrimination on what he called a Day of Affirmation. We, too, live in interesting times and its up to us, like Kennedy and Camus, to see it not as a curse but as a personal and political affirmation.

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From Camus' 'The Plague' To Dylan's 'Rough And Rowdy Days,' Sad Is The New Happy - WBUR

New guidelines aim to support mangrove restoration in the Western Indian Ocean – UN Environment

Nairobi, 24 July 2020 - For many coastal communities, including those in the Western Indian Ocean region, mangroves are critical to economic and food security. A new set of guidelines on mangrove restoration for the region aims to support the restoration of its degraded mangrove ecosystems and support recovery from the economic impacts of COVID-19.

Mangrove forests are among the most powerful nature-based solutions to climate change, but with 67 percent of mangroves lost or degraded to date, and an additional 1.0 percent being lost each year, they are at a risk of being destroyed altogether. Without mangroves, 39 percent more people would be flooded annually and flood damage would increase by more than 16 percent and US $82 billion. They protect shorelines from eroding and shield communities from floods,hurricanes, andstorms, a more important service than ever as sea levels continue to rise. Mangroves also providenursery areas for marine life and support many threatened and endangered species. Restoring mangroves can make communities more resilient to environmental changes and the economic shocks associated with the COVID-19 pandemic.

While governments acknowledge the importance of mangroves, the success of restoration efforts has been limited. The new Guidelines on Mangrove Ecosystem Restoration for the Western Indian Ocean Region analyze risks and challenges to restoration projects and point to potential solutions.

Coastal residents in the Western Indian Ocean region which includes Comoros, Kenya, France (Reunion), Madagascar, Mauritius, Mozambique, Seychelles, Somalia, South Africa, and Tanzania eat or sell the fish that live around the mangroves; harvest honey from the bees that the forests support, and use their wood as building material and fuel forsubsistence orsell it for income. Because the livelihoods of coastal communities depend on mangroves, restoring them can contribute to building back better through green recovery in the wake of the COVID-19 pandemic. Mangrove forests can also drive eco-tourism and create jobs.

Mangroves really are essential life support system for coastal communities in the Western Indian Ocean region, said James Kairo, Chief Scientist at the Kenya Marine and Fisheries Research Institute and lead author of the guidelines. If degradation continues, communities will be without resources for shelter or fuel, food, or a means to make a living.

The guidelines were developed by the member states of Nairobi Convention with support from UNEPNairobi Convention, the Western Indian Ocean Marine Science Association and the Western Indian Ocean Mangrove Network. They can be used by governments; resource managers; scientists; civil society, and communities at large as they embark on mangrove conservation and management initiatives.

These Guidelines are really the first for the Western Indian Ocean region to address past mangrove restoration failures head-on and assess the reasons why, said Jared Bosire, UNEPNairobi Convention Project Manager. Of critical importance is that they provide a step-by-step guide on how to build successful restoration projects which avoid several of the pitfalls that we have kept witnessing.

The Guidelines also feature case studies from around the Western Indian Ocean region, highlighting best practices and lessons learned. They can be used to guide action on mangroves as part of the upcoming UN Decade on Ecosystem Restoration (2021-2030) and support progress towards achieving Sustainable Development Goal 14.2 on protecting and restoring marine and coastal ecosystems. Mangroves also capture and store significantly higher rates of carbon dioxide per unit area than terrestrial forests, so mangrove restoration can be incorporated into countries Nationally Determined Contributions under the Paris Agreement.

Its hard to overstate just how important mangroves can be to both the environment and economy, said Kerstin Stendahl, Head of UNEPs Ecosystems Integration Branch. They are truly a super solution without them, wed have more carbon dioxide in the atmosphere, fewer fish and less food, and more damage from cyclones and other storms.

NOTES TO EDITORS

These Guidelines were developed under the Implementation of the Strategic Action Programme for the Protection of the Western Indian Ocean from Land-Based Sources and Activities project of the Nairobi Convention, funded by the Global Environment Facility.

About the Nairobi ConventionThe Nairobi Convention, signed by Comoros, France, Kenya,Madagascar, Mauritius, Mozambique, Seychelles, Somalia, South Africa, and Tanzania, aims to promote a prosperous Western Indian Ocean region with healthy rivers, coasts, and oceans. It provides a platform for governments, civil society, and the private sector to work together for the sustainable management and use of the marine and coastal environment.

About the UN Environment ProgrammeThe UN Environment Programme is the leading global voice on the environment. It provides leadership and encourages partnership in caring for the environment by inspiring, informing, and enabling nations and peoples to improve their quality of life without compromising that of future generations.

For more information please contact:

Keishamaza Rukikaire, Head of News and Media, UNEP

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New guidelines aim to support mangrove restoration in the Western Indian Ocean - UN Environment

Using artificial intelligence to smell the roses – UC Riverside

A pair of researchers at the University of California, Riverside, has used machine learning to understand what a chemical smells like a research breakthrough with potential applications in the food flavor and fragrance industries.

We now can use artificial intelligence to predict how any chemical is going to smell to humans, said Anandasankar Ray, a professor of molecular, cell and systems biology, and the senior author of the study that appears in iScience. Chemicals that are toxic or harsh in, say, flavors, cosmetics, or household products can be replaced with natural, softer, and safer chemicals.

Humans sense odors when some of their nearly 400 odorant receptors, or ORs, are activated in the nose. Each OR is activated by a unique set of chemicals; together, the large OR family can detect a vast chemical space. A key question in olfaction is how the receptors contribute to different perceptual qualities or percepts.

We tried to model human olfactory percepts using chemical informatics and machine learning, Ray said. The power of machine learning is that it is able to evaluate a large number of chemical features and learn what makes a chemical smell like, say, a lemon or a rose or something else. The machine learning algorithm can eventually predict how a new chemical will smell even though we may initially not know if it smells like a lemon or a rose.

According to Ray, digitizing predictions of how chemicals smell creates a new way of scientifically prioritizing what chemicals can be used in the food, flavor, and fragrance industries.

It allows us to rapidly find chemicals that have a novel combination of smells, he said. The technology can help us discover new chemicals that could replace existing ones that are becoming rare, for example, or which are very expensive. It gives us a vast palette of compounds that we can mix and match for any olfactory application. For example, you can now make a mosquito repellent that works on mosquitoes but is pleasant smelling to humans.

The researchers first developed a method for a computer to learn chemical features that activate known human odorant receptors. They then screened roughly half a million compounds for new ligands molecules that bind to receptors for 34 odorant receptors. Next, they focused on whether the algorithm that could estimate odorant receptor activity could also predict diverse perceptual qualities of odorants.

Computers might help us better understand human perceptual coding, which appears, in part, to be based on combinations of differently activated ORs, said Joel Kowalewski, a student in the Neuroscience Graduate Program working with Ray and the first author of the research paper. We used hundreds of chemicals that human volunteers previously evaluated, selected ORs that best predicted percepts on a portion of chemicals, and tested that these ORs were also predictive of new chemicals.

Ray and Kowalewski showed the activity of ORs successfully predicted 146 different percepts of chemicals. To their surprise, few rather than all ORs were needed to predict some of these percepts. Since they could not record activity from sensory neurons in humans, they tested this further in the fruit fly (Drosophila melanogaster) and observed a similar result when predicting the flys attraction or aversion to different odorants.

If predictions are successful with less information, the task of decoding odor perception would then become easier for a computer, Kowalewski said.

Ray explained that many items available to consumers use volatile chemicals to make themselves appealing. About 80% of what is considered flavor in food actually stems from the odors that affect smell. Fragrances for perfuming cosmetics, cleaning products, and other household goods play an important role in consumer behavior.

Our digital approach using machine learning could open up many opportunities in the food, flavor, and fragrance industries, he said. We now have an unprecedented ability to find ligands and new flavors and fragrances. Using our computational approach, we can intelligently design volatile chemicals that smell desirable for use and also predict ligands for the 34 human ORs.

The study was partially funded by UCR and the National Science Foundation.

The technology has been disclosed to the UCR Office of Technology Partnerships, assigned UC case number 2019-131, is patent pending, titled Methods for identifying, compounds identified and compositions thereof, and licensed to the startup company Sensorygen Inc. Founded by Ray in 2015, Sensorygen utilizes computational biology and artificial intelligence to discover natural replacements for toxic and harsh chemicals in everyday products, including finding new flavors and insect repellents.

The research paper is titled Predicting human olfactory perception from activities of odorant receptors.

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Using artificial intelligence to smell the roses - UC Riverside

Shield AI Recognized As One of the Most Promising Artificial Intelligence Companies – PR Web

Ryan Tseng and Brandon Tseng at Shield AI's San Diego office.

SAN DIEGO (PRWEB) July 29, 2020

Shield AI, the technology company focused on developing innovative AI technology to safeguard the lives of military service members and first responders, today expressed its gratitude to Forbes for naming the company as one of the AI 50: Americas Most Promising Artificial Intelligence Companies for 2020. The five-year-old company has developed AI technology that enables unmanned systems to interpret signals and react autonomously in dynamic environments, including on the battlefield. Shield AIs products are already being utilized by the US Department of Defense to augment and extend service members ability to execute complex missions.

Shield AI co-founder Brandon Tseng, who served in the U.S. Navy for seven years, including as a SEAL, said Following my last deployment, I came home with the strong conviction that artificial intelligence could make a profound positive impact for our service members. This was the idea that Shield AI was founded upon, and a half-decade later, we are elated to have Forbes recognize our innovation of AI technology as both promising and meaningful.

Shield AI has grown from fewer than 30 employees at the end of 2017 to nearly 150 today, while producing revenue metrics on pace with the growth trajectory of the most promising venture-backed start-ups, including doubling its revenue between 2018 and 2019. In an adjoining profile Forbes noted that Shield AI is is in prime position to capitalize on the nascent market consisting of autonomous technology linked to national security issues.

Shield AI has developed three cutting-edge products for its range of customers, spanning both software and systems. Its Nova quadcopter is an unmanned artificially intelligent robotic system which can autonomously explore and map complex real-world environments without reliance on GPS or a human operator. Nova is powered by Hivemind Edge, the companys intelligent software stack that enables machines to execute complex, unscripted tasks in denied and dynamic environments without direct operator inputs. The application is edge-deployed, with all processing and computation occurring without relying on a central intelligence hub, a critical need in environments lacking stable communications. The second software product, Hivemind Core, integrates data management and analysis, scalable simulation, and self-directed learning in order to radically accelerate product development workflows.

In the coming months, Shield AI will unveil a second generation Nova quadcopter aimed at bringing the power of resilient AI systems to an even wider array of mission sets, coupled with the ability to partner in real-time with operators to navigate tunnels beneath the earth and multi-level structures.

About Shield AIShield AI was founded in 2015 by Brandon Tseng, a former Navy SEAL, Ryan Tseng, a successful tech entrepreneur, and autonomy expert Andrew Reiter. Today the team is more than 140-strong, with Chief Technology Officer Prof. Nathan Michael of Carnegie Mellon Universitys Resilient Intelligent Systems Lab leading the companys development of AI systems that operate on the edge in challenging, previously unknown, real-world environments.

Follow Shield AI on LinkedIn

For Media Inquiries:Jessica Smythmedia@shield.ai

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Shield AI Recognized As One of the Most Promising Artificial Intelligence Companies - PR Web

Artificial intelligence needs an update on ethics to be able to help humanity in times of crisis – Economic Times

Currently ethics for AI focuses too much on high-level principles. Using AI to deal with crises would mean anticipating problems before they happen and building safety and reliability into it. Plus, ethics should be part of how AI is built and used, not an add-on or afterthought. Researchers and engineers need to think through the implications of what they build.

By Will HeavenJess Whittlestone at the Leverhulme Centre for the Future of Intelligence at the University of Cambridge and her colleagues published a comment piece in Nature Machine Intelligence this week arguing that if artificial intelligence is going to help in a crisis, we need a new, faster way of doing AI ethics, which they call ethics for urgency. For Whittlestone, this means anticipating problems before they happen, finding better ways

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Artificial intelligence needs an update on ethics to be able to help humanity in times of crisis - Economic Times

More than 800 hospitalised in Jordan food poisoning outbreak – The Guardian

A food poisoning outbreak in Jordan has hit more than 800 people and killed a child, all of whom ate cut-price shawarma from a restaurant outside Amman, the health ministry has said.

The owner of the restaurant selling the popular rotisserie meat and bread snacks in the Baqaa district north-west of the capital was arrested, local media reported.

A five-year-old boy died of massive poisoning, the ministry said in a statement.

Health minister Saad Jaber later said 826 people had been hospitalised with poisoning since the first cases were detected on Monday evening.

So far, 321 people are still in hospitals, all in a stable condition apart from four cases who are in intensive care, he told journalists. All those affected said they had eaten meals from the same restaurant.

He said hundreds of extra doctors and nurses had been drafted to various hospitals to treat those affected.

Earlier, the ministry said laboratory tests had revealed bacteria in the meat and poultry.

A special offer of a shawarma meal for one Jordanian dinar (about $1.40), or about half the usual price, had sparked an influx to the restaurant, said local news sites.

Health ministry official Adnan Ishaq told state television that the meat had become infected because it was not refrigerated.

A heatwave has hit Jordan in recent days, with temperatures in Amman exceeding 40C.

The district prosecution said three people from the restaurant, including the owner, had been detained.

Jaber said an investigation was underway. Any offender will be held accountable, regardless of who they are, he said.

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More than 800 hospitalised in Jordan food poisoning outbreak - The Guardian

Ronaldo is the Michael Jordan of football Lingard likens Man Utd legend to Chicago Bulls icon – Goal.com

The current Red Devils star considers a player he once worked alongside at Old Trafford to be a real icon on the back of his countless successes

Cristiano Ronaldo is the Michael Jordan of football, says Jesse Lingard, with the former Manchester United star and current Juventus talisman held up as a real icon in the sporting world.

Comparisons across sporting fields are difficult to make, with different skill sets required in order to reach the very top of contrasting games.

In NBA circles, Jordan reached the summit over the course of two iconic spells with the Chicago Bulls.

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He is rightly considered to be one of the finest sportsmen of all time, not just one of the greatest basketball players.

Few can claim to have scaled such heights in their chosen field, but five-time Ballon dOr winner Ronaldo does form part of that elite group.

Lingard, who once worked alongside the Portuguese at Old Trafford, admits as much, with a big basketball fan placing a Portuguese legend alongside Jordan on any roll of honour.

"I have to say Cristiano Ronaldo," the United and England midfielder told Sky Sports when asked if there are any footballers that can be likened to Jordan.

"Everything he has achieved in his career. He has been at plenty of clubs and won many trophies. I believe he is a real icon of football, the Michael Jordan of football.

"When [Ronaldo] first came to Manchester United, I was 11 or 12. We did a skills DVD and it was him teaching us skills which was good. That was the first time I had seen him. He was young and skinny when he came [to the club].

"I have played against him a few times. Did he give me trouble? No, he wasn't too bad, to be fair! There was one game in pre-season where he came on and you could see the skills and the qualities that he brought."

Basketball is preparing to return after a coronavirus-enforced break, with football having already led the way there.

Lingard will be an interested spectator when the likes of LeBron James and Zion Williamson return to the court, with the 27-year-old one of several avid NBA followers in the world of football.

"Basketball has different tactics and ways of playing and they set up a lot different [to football teams] but [as a player] you can relate. Certain players are small and agile and can bring their teams into games. That's similar to football," added the Red Devils academy graduate.

"When Romelu Lukaku was at Manchester United, he was very keen on basketball. He was in Miami with Paul Pogba playing basketball. I think those two would be up there, for me."

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Ronaldo is the Michael Jordan of football Lingard likens Man Utd legend to Chicago Bulls icon - Goal.com

Jordan’s Prime Minister Says His Country Contained COVID-19 By ‘Helping The Weakest’ – NPR

"From day one, any discussion of herd immunity or survival of the fittest or, you know, 'Say farewell to the elderly,' are the things that just did not sound right for us," Jordan's Prime Minister Omar Razzaz tells NPR. "So we went for a very different model in Jordan, based on social solidarity." Jane Arraf/NPR hide caption

"From day one, any discussion of herd immunity or survival of the fittest or, you know, 'Say farewell to the elderly,' are the things that just did not sound right for us," Jordan's Prime Minister Omar Razzaz tells NPR. "So we went for a very different model in Jordan, based on social solidarity."

Jordanian Prime Minister Omar Razzaz sits in the front room of his family home in a middle-class Amman neighborhood of traditional white stone houses with small gardens and low walls. Unusually, in a region where senior officials typically live in gated compounds far from public view, the residential street has been kept open to traffic to minimize disruption to Razzaz's neighbors.

Razzaz, an MIT and Harvard-educated economist, was appointed by Jordan's King Abdullah II to head a new government two years ago, following anti-government protests that were sparked by IMF-mandated tax increases seen as bypassing the rich. Although he'd served previously as education minister, Razzaz was seen as a relative outsider.

The small, resource-poor kingdom is surrounded by dangers from neighboring countries: a war in Syria, conflict between the U.S. and Iran in Iraq, and Israeli plans to annex parts of the West Bank it occupies something Jordan says poses a danger to the entire region.

But those issues have taken a back seat to controlling the coronavirus a feat Jordan has accomplished with an early and severe lockdown. The country of roughly 10 million has registered 1,131 coronavirus cases, with 11 deaths.

Razzaz sees vulnerable groups in other countries paying a disproportionate price for policies that don't prioritize them, and says Jordan's approach from the start was to protect the most vulnerable.

"From day one, any discussion of herd immunity or survival of the fittest or, you know, 'Say farewell to the elderly,' are the things that just did not sound right for us," Razzaz tells NPR. "So we went for a very different model in Jordan, based on social solidarity, in fact, helping the weakest. We did everything we can to make sure our children, our elderly, our refugees you know, the haves and the have-nots are protected."

In mid-March, Jordan was one of the first countries in the region to shut its airports and borders for all but essential goods. Arriving passengers were sent into compulsory quarantine. All but emergency workers and security forces were confined to their homes, with even grocery stores shut and the army distributing bread to poor neighborhoods.

The government cut public sector salaries and allowed businesses to reduce workers' wages, but banned them from laying off employees.

Razzaz says in the last four months, almost half of Jordan's population received some form of government assistance.

This week, the country announced it would reopen its airport to flights from a dozen countries where coronavirus rates are also low. With no cases of local transmission on most days, Jordan has stopped enforcing mask wearing and reopened restaurants and shopping malls.

Razzaz says industry production is now back to pre-coronavirus standards, and Jordan is exporting pharmaceuticals and food to other countries.

Jordan took a chance with the lockdown, he says, but felt it had little choice, given the prospect of its health care system being overwhelmed with COVID-19 cases.

"When we took the steps that we took, we did that not because we were certain about the outcomes. So there's always hindsight ... But we're very, very glad we did what we did. And a lot of countries that waited longer, including the U.S., ... are having a harder time containing the coronavirus," he says.

Razzaz and health officials note Jordan remains on guard for a possible resurgence of the virus as its airport reopens.

The longer-term challenge is an already fragile economy in which unemployment is rising sharply. Tens of thousands of Jordanians have lost their jobs in the Arab Gulf states, as those economies decline due to the pandemic and a plunge in oil prices.

The official unemployment rate for the first quarter of the year had already topped 19%. Some economists expect the real rate could reach 30% by the end of the year, with many of the unemployed young people.

Razzaz says, though, he is not worried by the prospect of renewed demonstrations that could be sparked by the economic crisis.

"While some countries worry a lot about social unrest, we see it as people expressing views about that hardship," he says. "We're going to be proactive with employment and job creation. And if you get frustrated and want to shout, we have a constitution and set of laws and institutions that allow that to happen in democratic ways."

The other wild card facing the kingdom is Israel's annexation threat. Jordan, along with Egypt, is one of only two Arab countries in the region to have signed a peace treaty with Israel. Jordan's king says he might suspend the 26-year-old treaty if Israel takes unilateral steps to claim sovereignty over parts of the West Bank.

Israel cites Jewish ties and a strategic need for it, but most of the international community opposes such a move, which could doom Palestinian hopes for an independent state.

Jordan, where a majority of citizens are of Palestinian origin, would be the country most affected by Israel's move, and instability could ripple across the region.

Razzaz says Jordan has not changed its insistence on the need for an independent Palestinian state alongside Israel.

"If you don't provide a just solution for the Palestinian people and sovereignty, you are pushing them and the region towards despair and extremism. So will there be conflict under such conditions? Yes, there will be, definitely," he says. "I think what His Majesty and Jordan have been doing is sounding the alarm bells."

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Jordan's Prime Minister Says His Country Contained COVID-19 By 'Helping The Weakest' - NPR

A New Womens-Exclusive Air Jordan 6 Colorway Set to Release in the Fall – Yahoo Lifestyle

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A new colorway of the Air Jordan 6 is hitting shelves soon and will be available exclusively in womens sizing.

According to social media leaker account @zSneakerheadz, the latest iteration of NBA icon Michael Jordans signature sneaker is releasing on Sept. 24. Jordan Brand revealed in June that this womens-exclusive style is launching as part of the Air Jordan fall 20 collection.

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Unlike many of the previous releases, the shoe features a mixture of materials starting with a premium suede upper thats elevated with transparent panels on the side. Additional details include inspirational messages including Be Kind, Embrace Uniqueness and Spread Love are printed on the sock liner, while a metallic Jumpman hangtag is attached. The look is completed with a black and white midsole and a translucent outsole.

The Air Jordan 6 made its retail debut in 1991 and was the sneaker that MJ wore when he won his first NBA championship with the Chicago Bulls against the Los Angeles Lakers. The shoe is famously inspired by one of his German sports cars, evident with the spoiler-inspired heel tab.

The aforementioned account is suggesting that the shoe will come with a $190 price tag when it releases on Sept. 24 and it will reportedly be available on the SNKRS app and at select Jordan Brand retailers.

In related Jordan Brand news, the anticipated Off-White x Air Jordan 4 Retro is releasing in the Sail colorway this Saturday on the SNKRS app and at select retailers for $225.

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A New Womens-Exclusive Air Jordan 6 Colorway Set to Release in the Fall - Yahoo Lifestyle

The emergence of virtual reality as a teaching tool in health care – DentistryIQ

In the course of history, dental education has progressed tremendously. Advanced teaching and learning methods have been developed and refined. Today, they aid greatly in the understanding of the etiology, diagnosis, and treatment of human diseases and conditions. But in dentistry, there is still a lack of an efficient and comprehensive methodology for proper patient carei.e., having a way to understand human anatomy in depth before treating live patients in a dental or dental hygiene program.

Enhancing tactile perception and assessment in education could greatly improve existing learning methods that complement a variety of teaching and learning methods. Virtual reality (VR), which is broadly used and is fundamental in fields such as aviation and telecommunication, is now emerging as a viable training tool in the health-care professionand dentistry stands to benefit.While providing an overview of the use of VR in dental education, this article will also explore the interrelationship between VR simulation and current pedagogical knowledge.

Traditional teaching and learning methods may not be as efficient or suitable for today's technologically advanced educational world, as students today most often rely solely on their tablets and laptops for their educational resources and academic success. Today, the internet has become a valuable supplement to education, forcing traditional lectures to become interactive, visual, and collaborative. The advantages of VR within dental education are continuously evaluated as a method to improve fine motor skills and hand-eye coordination within the clinical setting to surmount the financial and creative challenges that may be involved with such complex training.

Virtual technology in the medical profession is anticipated to flourish to $3.8 billion by 2020, according to a report by Global Industry Analysts.2 An additional report by Grand View Research concludes that the virtual industry will grow to $5.1 billion by 2025.2 This technology will further transform the health-care industry, with applications from training future and current health-care professionals to diagnosing and treating various conditions. Possessing the capability to lend complete, immersive 3-D virtual simulation for clinicians, VR technology continues to be perceived as an effective diagnostic and salutary tool for diseases and conditions such as fear and anxiety, autism, post-traumatic stress disorder, desolation, and pain managementparticularly severe pain in burn casualties.2

The implementation of virtual technology into training health professionals is changing the future of education and how students learn. VR provides virtual hands-on experiences for clinicians as they seek to reduce harm on live patients and offers opportunities to learn efficiently with long-term memory. By connecting an array of distinctive technologiesalong with an oculus headset containing a head-tracking system, headphones, and guidance with exploration devicesvirtual reality technology provides a multisensory and three-dimensional environment that helps users become completely immersed in an artificial environment.5

Virtual simulators have now become the norm in the fields of aerospace, aviation, and a few medical fields for neurosurgery, cardiovascular procedures, laparoscopy, vascular procedures, and certain biopsies to offer realistic, safe practices while providing feedback to the practitioner.1 Aside from creating realistic graphical feedback, illustrations, analysis, and renditions of the anatomical structures, simulators re-create all of the tactile sensations experienced during procedures and provide accessories to supplement instruments for grasping6 and palpating tissues so that clinicians can truly feel while performing the procedures.

In a best-evidence medical education (BEME) systematic review, researchers studied the capability of simulation technology in educational science. The study revealed that high-fidelity medical simulations are academically sufficient, simulation-based discipline complements to medical academics in a patient care setting and facilitate trainee learning.4 The study emphasized the importance of emulating real-life, regulated educational experiences in which learners are active participants in the process. Curriculum amendments are being directed by worldwide integration and global standardization, including new and advanced technologies such as oculus virtual simulation systems that provide unique capabilities for clinical training in medical academia.7

A current study by Johns Hopkins University claims that more than 250,000 people in the US perish yearly from medical failures, making it the third-leading cause of death after heart disease and cancer.3 The study outlined deaths due to medical error that were caused by an insufficiently trained staff, errors in judgment or care, and system defects. This includes computer malfunctions, botched medication types or doses administered to patients, and possible surgical complications that may go undiagnosed.3 The US patient-care study, released in 2016, investigated eight consecutive years of data for death rates. Analysts found that based on a total of 35,416,020 hospitalizations, there was a combined occurrence rate of 251,454 deaths annually derived from medical flaws. In 2018, two years later, the numbers remained the same.3

These virtual instructional programs will personalize learning to the individual needs and requirements of each student and provide prompt feedback and support once the problem area is identified. These technology-based simulation software programs can improve education and clinical skills, as well as minimize potential harm to living patients while simultaneously providing individualized virtual learning. Herbert Spencer, an English philosopher in the 1800s, stated, The great aim of education is not knowledge but action.8 The action Spencer argues is that students, the academic environment, and the instructors clout will devise change. Education involves the actions taken to utilize these educational resources. The fundamental objective of adept education is for students to become life-learners.

References

Staci Violante, DHSc, RDH, graduated from the New York University College of Dentistry Dental Hygiene Program in 1997. She went on to complete her masters degree at the Fones School of Dental Hygiene at the University of Bridgeport. She has been a practicing clinical dental hygienist for the past 20 years, as well as serving as clinical professor in the dental hygiene department at New York University College of Dentistry.

Related reading

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The emergence of virtual reality as a teaching tool in health care - DentistryIQ

EON Reality unveils addition of Virtual Reality World Heritage Sites to its AR and VR library – Auganix

In Virtual Reality News

July 23, 2020 EON Reality, a provider of augmented, virtual and mixed reality-based (AR/VR/MR) knowledge and skills transfer solutions for industry and education, has recently announced that for its latest addition to its AR and VR library, it has released a brand new update containing over 1,000 world heritage sites using immersive and interactive 360 images and 3D models.

The sites include famous locales past and present, including natural marvels like Americas National Parks and the Swiss Alps, man-made wonders such as the Golden Gate Bridge and the Great Wall of China, and historic locations such as Ancient Babylonia and the Great Pyramid of Giza.

Designed to provide educators and travelers with the ability to virtually visit and experience new places within the AR and VR library from the safety of their own homes, EON Reality states that each of the locations can have information added to them granting organizations the ability to build pre-made lessons, as well as a blank canvas to create a learning session about a specific topic. The company added that, particularly in a time when international travel is heavily prohibited for much of the world, giving users the opportunity to take field trips and vacations to a new environment in a matter of minutes can offer a valuable experience.

EON Reality stated that bringing these world heritage sites to its VR library lines up with the companys goals of providing accessible AR and VR education to as many people as possible, as well the companys own Global Emergency Initiative, which is aimed at helping solve remote education shortages. With many students unable to attend physical classes again until the COVID-19 pandemic is resolved, maintaining engaging and worthwhile educational materials has been a major undertaking for EON Reality in 2020.

EON Reality added that to date, much of its focus has been on replacing the hands-on training and education that it claims can only be replicated through VR. However, adding these new world heritage sites to its offering will give educators the opportunity to take students on virtual field trips that otherwise may not have been possible. For example, rather than teaching ancient history or foreign civilizations from a textbook, students can now experience it firsthand through the immersive platform.

The company closed its announcement by stating that: The addition also goes hand-in-hand with EON Realitys recent focus on self-directed learning as a means to teach both students and instructors to create their own immersive and interactive lessons through the Resource Center and other self-help tools.

Image credit: EON Reality

About the author

Sam Sprigg

Sam is the Founder and Managing Editor of Auganix. With a background in research and report writing, he covers news articles on both the AR and VR industries. He also has an interest in human augmentation technology as a whole, and does not just limit his learning specifically to the visual experience side of things.

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EON Reality unveils addition of Virtual Reality World Heritage Sites to its AR and VR library - Auganix