Faith in protest as young people find fervor on the street – La Grande Observer

NEW YORK I cant breathe! the crowd chanted, invoking the dying words spoken by George Floyd as a white police officer pressed a knee into his neck.

Kianna Ruff yelled it over and over along with hundreds of fellow protesters as they marched for hours through New York City, a kind of collective mantra that touched someplace deep inside those present.

I just started choking and I broke down, the 28-year-old activist and minister said. And I do feel like that that was also a spiritual experience that Ive never experienced before.

The demonstrations against police brutality and systemic racism that have raged in the wake of Floyds killing are often led by young people who find a sense of purpose, ritual and community on the streets. Many involved say the protests deepen spiritual connections and embody familiar elements of traditional faith.

The demonstrators kneel. They observe mournful moments of silence. They break into call-and-response: What do we want? and Justice! From Los Angeles to New York, Milwaukee to Minneapolis, they stand shoulder-to-shoulder and find common cause in their shared fervor.

I can say this is liturgy in the street, said the Rev. Jacqueline Lewis, pastor of the Middle Collegiate Church in New Yorks East Village. This is church in the street, it is song in the street, it is lament in the street. The tears are in the street.

When the kids say, Black Lives Matter! Lewis continued, thats a prayer.

Americans are becoming less religious in the formal, traditional sense, and the trend is more marked among young adults, according to Pew Research Center surveys from recent years. Young people, who make up a core part of the protesters, are less likely to pray daily, attend religious services or believe in God.

Still, surveys show younger Americans are just as spiritual as their older counterparts, and many have found other expressions of faith outside formal religion.

In its How We Gather study, Harvard Divinity School researchers documented wide-ranging spiritual communities for the young ranging from Afro Flow Yoga and dinner churches to public meditation groups.

Fears about the future have also led many to activism. Tens of thousands walked out of schools in 2018 to demand action on gun violence in one of the biggest student protests since the Vietnam era. Inspired by Swedish teenager Greta Thunberg, hundreds of thousands marched worldwide in 2019 demanding urgent action on climate change.

This year that has manifested in the struggle against police brutality and racism.

All of these issues intersect because they all disproportionately impact Black people, said 19-year-old Aalayah Eastmond, who survived the 2018 mass shooting at Marjory Stoneman Douglas High School in Parkland, Florida, became a gun-control activist and is now organizing protests against racial injustice with the group Concerned Citizens of D.C.

Her group begins demonstrations with a collective prayer thats inclusive of nonbelievers, she said the point is closeness and togetherness.

We stand in a circle and one person just prays for us to one, be safe in the middle of these protests, because they can get very violent. ... And for folks to really feel empowered and moved while theyre protesting, Eastmond said.

Nationwide, the demonstrations have tended to be diverse in terms of markers like generation, ethnicity and gender, but Ruff, a graduate of the divinity school at Union Theological Seminary in New York, said community thrives despite such differences.

Its about being in those groups and feeling that energy, you know, that God wants you there, Ruff said.

And theres so many people, she added. Whether they believe what you believe or not, thats not whats important. Whats important is the common goal.

During a recent Buddhists For Black Lives Matter march in Los Angeles, Tahil Sharma walked with others in a slow, wordless procession whose silence had a similarly powerful effect as the chanting of other demonstrations.

That march was so different. ... The emotional swelling that we felt of every second passing as we were breathing and praying was a reminder of the seconds of air that George Floyd was gasping for, said Sharma, a 28-year-old interfaith activist born to a Hindu father and a Sikh mother.

Many demonstrations have seen protesters honoring the dead by reciting their names in what resembles a litany.

Another common element is the creation of spaces explicitly or implicitly spiritual in nature and symbolism: In Minneapolis, protesters set up a floral altar memorial at the site where Floyd died, while in Houston, a newly painted mural depicts him with an angelic halo and wings.

People bring in pictures, flowers, theyre burning candles, incense, making music and really kind of creating a physical space where theyre holding the spirit of a loved one, said Casper ter Kuile, author of The Power of Ritual: Turning Everyday Activities Into Soulful Practices.

Theres a really interesting kind of lived religion, as sociologists would call it, on the streets within these protests, ter Kuile said.

In Milwaukee, a Muslim artists collective recently spent hours painting a mural depicting a family on a sofa under the words: Our Kids Will Not Be Next, as passing drivers honked horns in solidarity.

Art is a perfect middle ground for people to unite, said Amal Azzam, the 27-year-old co-founder of Fanana Banana, which organized the event. Milwaukee is a very segregated city. ... These are the things that help connect the communities.

Thats a sentiment shared by Sharma, in Los Angeles, who became involved in interfaith literacy and social justice following the 2012 deadly shooting at a Sikh temple in Oak Creek, Wisconsin.

When I see that entire world marching with me to fight for the rights of others, I feel I am in prayer, he said. When we shut down systems of oppression together, acknowledging our differences for a common cause, thats when I know my prayers are being answered.

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Faith in protest as young people find fervor on the street - La Grande Observer

Suikodens creators are crowdfunding a spiritual successor – The Verge

Some of the key creators behind the beloved Suikoden franchise are attempting to crowdfund a spiritual successor. Today, a new team called Rabbit & Bear Studios announced an upcoming Kickstarter campaign to fund Eiyuden Chronicle, a roleplaying game designed to evoke PlayStation-era nostalgia. The campaign will debut on July 27th, and the team is led by Yoshitaka Murayama, director and writer on the first two Suikoden titles. This is a new title for me, Murayama tells The Verge. Or rather is a combination of all my experiences as a creator and trying to expand on that base.

Aside from Murayama, Rabbit & Bear features an impressive list of talent. That includes: Junko Kawano, the lead artist on Suikoden 1 and 4; Junichi Murakami, art director on Castlevania: Aria of Sorrow; Suikoden Tactics director Osamu Komuta; and composers Motoi Sakuraba and Michiko Naruke.

Over the past years the core creators have met up at different events, and of course you talk about the glory days as well as regrets, Murayama says. One common thing that always came up was Isnt it about time we make a game for ourselves? Something we really want to make? Something we can make for the fans? And that dream provided the spark for this current project.

For fans of the Suikoden franchise which debuted in 1995 but has been dormant for many years the new game will sound very familiar. Eiyuden Chronicle is described as an ode to the classic JRPG genre from the PlayStation era that will feature classic JRPG exploration and battles in high-resolution 2.5D graphics with a story of war and friendship and a diverse cast of 100 unique heroes. If the crowdfunding campaign is successful, Eiyuden Chronicle is expected to launch in the fall of 2022 on PC, with other platforms possible depending on stretch goals.

Heres the basic premise, according to the studio:

Our story begins in one corner of Allraan, a tapestry of nations with diverse cultures and values. By dint of sword, and by way of magical objects known as rune-lenses, the lands history has been shaped by the alliances and aggressions of the humans, beastmen, elves, and desert people who live there. The Galdean Empire has edged out other nations and discovered a technology that amplifies the rune-lenses magic. Now, the Empire is scouring the continent for an artifact that will expand their power even further. It is on one such expedition that Seign Kesling, a young and gifted imperial officer, and Nowa, a boy from a remote village, meet each other and become friends. However, a twist of fate will soon drag them into the fires of war, and force them both to reexamine everything they believe to be right and true.

Of course, even with established creators at the helm, crowdfunded video game projects can go awry. Back in 2017, the creator of PaRappa the Rapper failed to crowdfund a spiritual successor due in part to the extremely early state of the game. Other projects have run into issues around funding and delays. Even with these concerns, Murayama believes a platform like Kickstarter is the best option for this type of game.

While people have their valid complaints about crowdfunding, it still provides one of the only ways to connect to your core fans, he says. Anyone who is passionate enough to invest in a project 2-3 years in advance and have that hope and belief in something is the type of fan that you want to collaborate with. They in turn motive you and can help us get to our dream of making that game we really want to make. Its hard to say whether people will choose to believe or to just doubt in this day and age, but every person who chooses to have faith in this project, I see as a hero. They are certainly the hero of my personal story.

That said, it doesnt sound like the studio has a backup plan in case crowdfunding falls through. When asked what would happen if the Kickstarter campaign failed, Murayama said Hopefully some rich benefactor will take me in and let me live in their house.

The Kickstarter campaign will kick off on July 27th and run through August 28th.

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Preview: Halo Infinite is a spiritual reboot of the linchpin Xbox series – GeekWire

An unidentified character from Halo Infinite. (Microsoft Xbox / 343 Industries Image)

Microsofts 343 Industries revealed more information Friday about its next game in the Halo franchise, the forthcoming Halo Infinite. In a series of closed Q&A sessions with journalists, held via Discord, 343s Chris Lee and Paul Crocker provided additional context and commentary for the campaign footage from Infinite that made its debut on Thursday mornings Xbox Games Showcase.

They described Infinite as not simply a sequel, but as a spiritual reboot to the series, and a platform that 343 can use to keep building on the Halo universe.

Microsoft is banking on Halo Infinite as a killer app for the new Xbox Series X, debuting later this year. Halo has been a tentpole franchise for the Xbox line of consoles for almost 20 years, dating back to the original game in 2001.

As part of the reboot, Infinites story campaign takes players back to basics. The high stakes and galactic scale of the last two games are, at least for now, gone. Youre once again playing as Master Chief, fighting your way across one of the Halo rings that named the franchise, up against a familiar array of Covenant aliens.

Specifically, youre fighting the Banished, a power-hungry splinter faction within the Covenant that was previously introduced in 2017s Halo Wars 2. The larger Covenant War is still over, but the Banished are still a going concern, and at the start of Infinite, have just captured a human research facility on a Halo construct. The Master Chief ends up stuck in the middle of Banished territory, under circumstances that have yet to be revealed, and is forced to shoot his way back out.

Infinite is still 100% a sequel to Halo 5, according to Crocker, but is also an attempt to distill much of the seriess traditional appeal into a single experience. The critical pillar of their design, as per Lee, is to draw on the entirety of the Halo franchise to date, to take all the things that worked and put them into Infinite at the point at which they were at their best.

When I first stepped out onto the ring in Halo: Combat Evolved all those years ago, Lee writes for Halo Waypoint, I was transported and immersed in a mysterious, awe-inspiring alien world extending into the sky With Halo Infinite, were now able to give players more freedom than ever before to explore a sprawling Halo ring.

Its a strange choice, but it explains the retro feel of the footage from the Showcase. The general idea behind Infinites design seems to be starting over, to try to recapture some of the original games impact and its difficult to overstate just how impactful the original Halo was, back in 2001 and use that as a basis for continuing to build out the Halo universe. They arent pushing the envelope here; theyre reinventing the wheel.

Lee and Crocker said that the map for Infinites campaign mode is several times bigger than that of Halo 4 and 5 put together, with more ways to explore it and rewards for doing so. Lee calls Infinite the most open, expansive campaign weve created, with the ability to reach and explore any area that you can see as you make your way across the ring.

While youll still have access to many of the traditional travel methods in Halo games, such as the seriess traditional human and alien vehicles, the big new addition introduced in the Showcase footage is the grapple shot. This is a retractable line built into the Chiefs gauntlet that lets you scale cliffs, rappel towards distant ledges, and pull both enemies and items over to yourself. The grapple shot lets you find new ways around the battlefield, to find your way to distant locations or spring sudden ambushes on enemy positions.

Youll also have access to a personal cover item that 343 calls a Drop Wall, a portable energy shield that you can use to deflect gunfire or even grenades. Both the grapple shot and the Drop Wall will be accessible in the games multiplayer modes, but as item pickups rather than standard character equipment.

Infinite runs on a new engine called Slipspace, named after the warp drives that power the Halo universes spaceships, which offers a previously-impossible degree of visual fidelity. This is a big reason why so much of the Showcase footage of Infinite was focused on the games new antagonist, the Banished warlord Escharum. His face by itself represents more fine detail in its character model than past Halo games were capable of, which opens up a lot of options for a virtual actor.

That in itself is significant. In a franchise thats traditionally known for high spectacle and pitched firefights, the big trailer moment for Infinite so far is a scene where an alien trash-talks you for a solid 90 seconds. Its a well-rendered, expressive alien, in a scene that wouldnt have been as colorful or detailed on the Xbox One, but its a strange choice for a trailer that was expected to showcase the technical might of the new Xboxs flagship title.

In fact, Infinite so far is a rough collection of strange choices. Microsoft has spent the better part of the last year hyping up the Xbox Series X as the most powerful video game console ever released, but its hotly-anticipated flagship title is a deliberate throwback to a 19-year-old game that, in the most extensively curated clip they could put together, still looks borderline retro.

However, the strategy behind Infinite also seems to mirror that of Microsoft with the Games Showcase itself. Both the Series X and Halo Infinite are foundation stones, seemingly built as something that Microsoft and 343 can build upon rather than as traditional products. The general thrust of the games shown at Thursdays Showcase was primarily towards their variety and accessibility, while Infinite is being specifically built as an easy jumping-on point that 343 can proceed to iterate upon.

Halo Infinite is still scheduled to release as a launch title for the Xbox Series X, the release date for which is still an unspecific point in the 2020 holiday season.

Infinite is the sixth mainline game in the Halo franchise, which began in 2001 with Halo: Combat Evolved. Set in the 26th century, the games initially tell the story of an interplanetary conflict between Earths United Nations Space Command and an alien coalition called the Covenant. While the Human-Covenant War ended with 2007s Halo 3, later games and related material have dealt with the events that followed the war. The franchises name comes from the Halo rings, a series of alien-built habitats that have provided the settings for several of the games, and which turned out to be the firing elements in an ancient super-weapon.

Originally developed by the Bellevue, Wash.-based studio Bungie, Halo was regarded as the killer app for the original Xbox, and the games in the franchise are a significant driver of the Xboxs overall success as a platform.

In addition to the previous core games in the series, Halo also includes a line of best-selling novels, comics, and animated films, in addition to spin-offs like the strategy-based Halo Wars. Halo is currently developed by the Microsoft-owned 343 Industries, based in Redmond, Wash.

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The spirituality of the vacations is agency regardless of Corona – Pledge Times

Khawla Ali (Dubai)

The consequences of the Corona pandemic affected the atmosphere and rituals of the feast, and made us express our joy with its minimalistic solutions, committed to wearing the new, and willing to draw the features of this day, which looks different from the image we used to. We have come to realize the value of compassion and the importance of visiting, at a time when we are responsible towards ourselves and our community for adhering to preventive measures, to the extent that guarantees us and others safety. It remains for the feast, the glory and spirituality that we feel with the enlargements that the minarets shout in the morning, and our tongues rage behind it, cheering and arrogant, for it is the holiday that refuses to give up his spirituality in all circumstances.

In this context, Sheikha Al-Hajri (housewife) explains: We did not accustom the holiday to be from a distance, but we insist that we live in an atmosphere by adhering to showing rituals, and communicating even if it is electronic, so that we can bring joy to our children and our families, draw the joy of the feast, and create a beautiful atmosphere At home, away from the daily routine.

Our authentic customsAs Al-Yazia Al-Hosani (educational) says: The borders that we are forced to sometimes compel us to look around, instead of far away. And with the pandemic, we realized the importance of estimating things that we considered simple. Such as communication and its beautiful effect on souls, such as handshaking, kissing the heads of the elderly, family sharing dishes, and other behaviors that bring joy and joy and express the concept of the feast. On the other hand, we realized the huge amount of extravagance that we used to follow during the holidays, took simplicity, went back to our original customs, and wore the traditional dress (mkhawir), and we spent time with the most important people in our lives, whether through visual contact, or limited visits Among the first-class family, what emptied our minds of preoccupation with luxuries, and life became simpler than we imagined, and we became more concerned with moral matters, what was reflected on our souls, which became more light, and who knows? Maybe we will spend the holidays after the pandemic in new ways.

Self-discoveryJamila Al-Watani (lawyer) says: Eid, in any case, I returned, Eid What happened to a mother with an order in which you have renewal This house for the Mutanabbi in the Abbasid era, and with different times, this house stops us with the coming of Eid in light of the existential, psychological and physical spacing Imposed by the Corona pandemic, by its ability to set joys aside, including sticks, and some religious rituals, and forced us to meet by wearing gloves and avoiding handshaking, without deep embrace and spiritual smiles that appear behind the gags. And she explains: The passage of the two feasts in this case, perpetuates isolation, and steals the joy of attending the feast, but the conscious and productive man added a third feast to his life, which is the feast of challenge, when he comes out of forced isolation with important results, the first of which is creating an optimistic life model, and the second is transforming the laziness of isolation into a workshop Work, and expand the size of human and moral relations, and the third is self-discovery and self-confidence .

Positive thinkingHoda Al-Taher (housewife) confirms: The feast of 2020 will keep their memory alive. How can we forget holidays that coincided with the epidemic of the heart of the world upside down overnight, because the feeling and joy of the feast is not consistent with the word epidemic? The solution of Eid Al-Adha and the world is still Im walking the atmosphere of Covid 19, but we thank God, we lived the previous Eid Al-Fitr in the same circumstances, but we learned a lot from him, yes the Tarawih prayer did not take place in the mosques, but I will not forget my children rotating their Imam daily at home, and its conclusion with Eid prayer at home for the first time in My life, yes, it is an epidemic, we ask God to remove it from us, but it taught us to define the priorities of life: family, health and education. For her part, Maryam Fakhro (plastic artist) says: things differ from one person to another in how to deal with the events around him, the global epidemic imposed isolation on us, so that we remain safe, but in return, he charted for us a more positive way in our life, we looked at Aspects we were ignorant of, or we were not aware of its value, such as getting to know the neighbors, because the fast pace of life put us in a whirlpool, but the time of Corona was a real pause with the soul, during which we practiced a lot of sports activities, and interaction increased with the family, and we became delighted with the beauty of nature, And we realized the value of things around us. Live the moment and enjoy the positive energy in your bodies, minds and hearts, and fill life with love and generosity, she adds.

Half of the cup is fullIsraa al-Samarrai (university professor) says: These events that happen to us, make us recall the hadith of the Messenger of God, peace and blessings be upon him: Whoever of you becomes safe in his swarm, recovering in his body, has the strength of his day, as if the world has attained it with its fountains. Praise be to God for That is, if we program our thoughts in this way, we will be happy with what God has given us, and look at the full half of the cup, then we will feel the pleasure of what we are in, and forget what else is, so our awareness is what makes us happy, or unhappy. It is true that a feast has passed and a holiday is feast, and the world is still suffering due to the spread of the Coronavirus, but we are still alive and enjoying our health, and if we were not with pilgrims on a regular basis, we can be proud and satisfied while we are in our homes, and we feel the pleasure of that, To draw closer to God through various obedience, which in turn brings satisfaction, tranquility and calm to ourselves, and this is the height of happiness. She added: To adapt to our current circumstance, by taking the precautionary precautions and the obligation to protect ourselves and our families from the threat of the virus, explaining: This epidemic will go, and we will return to our normal life, which we did not feel its pleasure previously.

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The spirituality of the vacations is agency regardless of Corona - Pledge Times

Exorcising Quetzalcoatl: Spiritual Warfare in Guatemalaand Beyond – Patheos

In the 1990s Harold Caballeros was minister of a church of 350 members in Guatemala City. It was growing and going well, and they had found valuable real estate at an affordable price on one of the main avenues of the city. Caballeros exulted that it was an absolute miracle.

Then everything went wrong. As he prayed one day in his office, leaning on a stool in front of a bureau, the stool began to elevate and then disappeared. In its place lay an enormous coiled white snake. As it came alive, furious and menacing, its eyes stared red, profound, and charged with hate. Caballeros began to tremble with fear. It is true that in my work as a pastor I had participated in deliverances, he reported. He had seen demonic manifestations, but nothing compared with this moment.

Then, he said, the Lord Jesus Christ intervened. From within his own chest came a voice with power and authority. Isnt My name enough? Is the authority of My name not enough for you? Caballeros realized, I wasnt alone. He was with me.

Filled with hope and resolve, Caballeros approached the ten-meter-long snake. Though it betrayed no fear, the pastor rebuked it in the name of Jesus Christ. I could see that what the serpent was losing in confidence, I was gaining. Unexpectedly I could feel that fear had disappeared from me, and the serpent started to uncoil. The fight was tougher by the moment, and I soon saw fear it its eyes. I was obtaining victory. . . The serpent backed away and suddenly, traversing the wall, it went into the street.

Surprising even himself, Caballeros took chase, following the snake into the middle of Sixth Avenue. Continuing to rebuke it for several blocks, he finally ordered the serpent with all the authority he could muster, to flee. The intervention worked. He reported that the snake moved with greater speed by the moment, fleeing, afraid.

This spiritual experience fortified Caballeros for what came next. After El Shaddai Church began to build, the governments Institute of Institute of Anthropology and History put a halt to construction. The church stood on a pre-Columbian archaeological site: The Great Mound of the Snake of the Valley of Guatemala, which had been discovered only thirty years before.

Stuck, Caballeros began doing his own research which he said was guided by the Holy Spirit. He discovered that the Mound of the Snake was made by indigenous hands about two hundred years before Christ. Built in the form of an elongated pyramid, the mound was thirty meters wide, fifteen meters high, and twenty-two kilometers long. It was used ceremonially to honor Quetzalcoatl, the flying serpent.

Caballeros agreed with anthropologists that the Mound was significant. He disagreed with them about exactly how. To this Pentecostal pastor, the Mound signified a corruption of gospel truth. He explained:

Each year, during the spring solstice, this serpent undergoes a particular process. Its skin becomes opaque and dry, all its body acquires a gray-like color, a veil falls over its eyes, as would a cataract, and abruptly the viper breaks its covering, abandons it and emerges with a new skin, alive and fresh. The it adds a new rattle. This phenomenon is called caput zijil, which means, To be born again. If we add to this that the number four is the number of the sun and of Quetzalcoatlof whom is said that he died for his people and came back to life on the fourth daywe will see that we are facing a falsification of Christ

Caballeros further reported that for the Mayas, the cult of the serpent took on such importance that they went to the extreme of taking two tablets to pressure the skull of their children and, in the process, deform them. They would file down their childrens teeth and voluntarily make them cross-eyed, in an effort to make them physically similar to the serpent.

The most important moment in Caballeross research came when he and other church leaders spotted Quetzalcoatl in Hebrew scriptures. We could barely believe our eyes. Through the book of Isaiah, God was confirming our findings. The specific passage was Isaiah 14:29: Do not rejoice, all you of Philistia, because the rod that struck you is broken; for out of the serpents root will come forth a viper, and its offspring will be a fiery flying serpent. They also found Quetzalcoatl in Isaiah 30:6: The burden against the beasts of the South. Through a land of trouble and anguish, from which come the lioness and lion, the viper and fiery flying serpent, they will carry their riches on the backs of young donkeys and their treasures on the humps of camels, to a people who shall not benefit them.

Caballeros determined that this prophecy had become terrifyingly true for the countries of Meso America. They had been handed over to, dedicated to, or given over to this evil spirit. The cultures of pre-Hispanic America had been given an inheritance of curse, darkness, and pain to the next generations. Instead of worshipping the true God, the Maya, Aztec, and Inca worshiped birds (the quetzal), animals (the jaguar), and reptiles (the rattlesnake). And they sacrificed humans. Caballeros explained, During all of the research process, our attention was powerfully drawn to the bloodthirstiness of that cultthe human sacrificesand the unique way in which the sacrifices were conducted.

What did this inheritance look like in Caballeross twentieth-century Guatemala? The equivalent to ancient human sacrifices, he maintained, was the radical politics of socialist guerrillas, who had destabilized society and caused economic problems. Significantly, Caballeros pointed out, the quetzal was the national bird and name of the currency. He wrote, The number of crotalic or serpentine symbols in them increased in direct proportion to the devaluation of the currency.

The bottom line: political virtue requires spiritual integrity. We understood, said Caballeros, that the intervention of the church is necessary to settle those ancestral problems spiritually if we want to see the freedom of our nations. . . . God was speaking to us, letting us know that the situation of our nation was due to spiritual circumstancesto the direct action of forces that were hidden to the human eyebut that are absolutely real.

Feeling a sense of urgency, Cabelleros conceived of a project called Jesus is Lord of Guatemala. He recruited a great army of intercessors who would redeem the nation from the hands of the enemy, and together they read the book Prayer, the Key to Revival by Korean pastor David Yonggi Cho. Based on this template, Caballeros held an exorcism in which he sought to expel Mayan spirits from strategic zones around the city. At one site, he killed an actual snake that stared hatefully at him from an aqueduct linked to ancient Mayan ruins.

It seemed to work. El Shaddai successfully built on the site, and attendance multiplied by seven in only two years. The church, said Caballeros, also grew in quality. It became a praying church, a warring church. When a member of the church, Jorge Serrano Elas, became a candidate for the presidency of Guatemala in 1991, the church prayed for his victory. Teams from El Shaddai fanned out to strategic cardinal points across the nation to clear the way of strongmen who might overtake Serrano in the polls.

When he won the election, Serrano called for a national exorcism. Members of El Shaddaialong with 75,000 other evangelicalsparaded through the streets of Guatemala City to declare to the principalities and powers that Jesus, not Maximn or any other false god, is Lord over Guatemala. This event represented an evangelical surge in a nation that was already the most evangelical in all Latin America after its Protestant population had risen from 2 percent to 40 percent in less than four decades.

This basic narrative comes from a chapter in a 2001 book published by Thomas Nelson called Victorious Warfare: Discovering Your Rightful Place in Gods Kingdom. Written matter-of-factly by Caballeros himself, How I Learned That Spiritual Warfare Exists is an exemplary articulation of Guatemalan Pentecostalism. It is impossible, says the chapter, to disentangle the material from the immaterial. Spiritual warfare can be found in everyday life. Prayer has material consequences. As Caballeros put it, Spiritual warfare really constitutes the normal way of life for the believers that have been redeemed by Christ from the slavery of the devil. Pentecostals believe that there is a spirit world populated by angels and demons warring over poverty, substance abuse, domestic violence, and the soul of every human being.

Critics, noting that the story did not end with the election, do not agree. Serrano was exiled to Panama in disgrace after he illegally suspended the Constitution, imposed censorship, and dissolved Congress and the Supreme Court. Indeed, evangelicals have remained silent about the violence inflicted by their own. As scholar Maren Christensen Bjune has contended, Pentecostal participation in politics has not transformed politics as much as preserved the status quo. Others say that spiritual warfare eradicates the nations own heritage by blaming Mayan culture for negative, superstitious, and violent characteristics of Guatemalan culture.

Whatever the case, Guatemalan Pentecostalism enjoys far greater range than just Guatemala. El Shaddai now boasts 12,000 members in Guatemala Citybut also more than eighty branch churches in several countries in America and Europe. It enjoys close ties with the New Apostolic Reformation, a Pentecostal network with ties to Michele Bachmann, Sam Brownback, Sarah Palin, Rick Perry, and Ted Cruz. The Spiritual Warfare Network, which Caballeros helped develop, covers the globe, and one of its meetingsthe 2006 World Congress on Intercession, Spiritual Warfare, and Evangelismwas hosted by El Shaddai and included representatives from twenty-four nations.

Indeed, what is most striking to me is how transnational the spiritual warfare movement is. This story alone involves a Korean prophet, an American vice-presidential candidate, an Argentinian pastor, and a Guatemalan president. The global circulation of religious ideas and practices, on overdrive since the Immigration Act of 1965, continues even during 2020 pandemic. In the last few months Caballeross podcasts and Youtube sermons on a range of issues related to spiritual warfare have been getting a lot of play in Guatemala, the United States (check out the books on his desk in this video), and around the world.

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Exorcising Quetzalcoatl: Spiritual Warfare in Guatemalaand Beyond - Patheos

St Mary of The Cross MacKillop the Patron Saint for Australian Catenians – Catholic Outlook

On Tuesday 28 July, the Australian National Council of The Catenian Association and the Sisters of St Joseph announced that St Mary of The Cross MacKillop will become The Catenians Patron Saint for Australia on 8 August 2020, the Solemnity of the Saint.

The Catenian Association is an international fraternity of Catholic laymen. Founded in Manchester in 1908, it was established in Australia in 1971 and now has approximately 900 Australian members.

Speaking from the Mary MacKillop Chapel North Sydney following a Mass to celebrate St. Mary MacKillops feast day, the Associations Australian National President, George Kazs, said that following the beatification of Mary MacKillop in 1995, Australian Catenians have adopted the practice of seeking her intercession at the commencement of meetings and when new members join the fraternity.

Since then, Sisters of the Congregation through their generous support have enriched the spiritual life of Catenians through encountering the charism of St Mary MacKillopher faith in a loving and provident God, her uniquely Australian response to Gods call to provide for those in need, her respect for the dignity of all and her affection for her Sisters and for those she served.

These encounters have opened Catenians to the possibility that life as a Catenian can be lived with a uniquely Australian spirituality within an international context. That, like St Mary MacKillop, a Catenian can be truly Australian and strive to be genuinely holy, he said.

Through her example of prayerful and attentively listening for the movement of the Holy Spirit, Australian Catenians have discerned that an Australian expression of Catenian spirituality is a spirituality of interdependence, one lived through faith, friendship, respect and service. A spirituality that reflects the charism of St Mary MacKillop.

The Association wished to acknowledge that the Australian expression of Catenian spirituality reflects the charism of St Mary MacKillop by adopting her as its Patron Saint for Australia and requested the Congregation to support it in making this acknowledgment.

The Congregation has agreed to support the Association in acknowledging its adoption of St Mary of The Cross MacKillop as its patron Saint for Australia by its representatives joining with members of the Association in a ritual of adoption held at the Saints tomb during the celebration of a Mass of her Solemnity on 27 July 2020 and by joining with the Association in announcing its adoption of the Saint as its Patron Saint for Australia.

Speaking after the Mass Sister Monica Cavanagh RSJ, the Congregational Leader of the Sisters of St Joseph, said that the Sisters are delighted to share this occasion with the Catenians. She went on to observe that from the earliest days of the Institute Mary MacKillop recognised the importance of establishing partnerships with people who supported her work and mission. Mary MacKillops way of living the gospel in our Australian context aligns closely with values at the heart of what it means to be a Catenian. Her practical down to earth spirituality has much to offer the work of the Catenians in Australia today.

With thanks to the Australian National Council of The Catenian Association.

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St Mary of The Cross MacKillop the Patron Saint for Australian Catenians - Catholic Outlook

The Spiritual Theme Of the Week Ahead Is AwakeningHeres Exactly What To Expect – Well+Good

Cosmic Health is your day-by-day source of celestial advicewith a wellness twist. Astrologer Jennifer Racioppi looks to the stars to find out whats in store for your week when it comes to food, fitness, sleep, sex, and more. See All

With the sun zooming through the early degrees of Leo, and the last week of July upon us, its time to make the most of the summer, pandemic in tow. With just a few weeks of peak-season sun left, its essential to find joy where ever you can and to savor those moments. Thankfully, astrologically speaking, the next few days allow for an enhanced experience of spiritual well-being. Even with a cardinal square brewing between Mercury in Cancer, Mars in Aries, and the ongoing stellium in Capricorn, there are uplifting aspects, like Mercury square Mars, that are worthy of highlighting and leaning into.

For starters, on Monday, Neptune, the planet of dreams, makes a sextile to Jupiter in Capricorn. When Neptune sextiles the biggest and most expansive planet in the sky, you can quite possibly catch a wave of spiritual growth. Neptune in Pisces offers a sense of transcendence, and as he approaches this harmonious angle to Jupiter, which perfects on Monday at 12:06 p.m., ET, your intuition, emotional awareness, and ability to visualize amplifies.

On the same day, Venus in Gemini makes a square to Neptune. While a square often indicates a challenge or challenges, in this situation, it amplifies the mystical. Venus is now making her third square to Neptune, with previous squares having occurred on May 3rd and May 20th. Since this is the third in the sequence (due to her retrograde in Gemini), we can potentially experience a deep spiritual knowing akin to awakening.

Venus squaring Neptune invites in the dream. After months spent refining and coming to a deeper understanding of the personal values that guide your life, its essential to now claim the essence of what youve refined since early Maya perfect activity for the waxing moon. Take a moment and reflect on what youve learned. Pay attention to what you are releasing, and connect to the new dream emerging from within.

To tap into the essence of Jupiters sextile to Neptune and the planet of dreams square to Venus, check out Taylor Swifts latest album, Folklore,which she surprise released last week, right after the sun moved into Leo. Its lyrically, sonically, and thematically on point with these transits, serving both as a therapeutic source and artistic inspiration. Like the week ahead, it embodies a whimsical, soft but deep and true to self essence of magic. The highest calling under these transits is to animate the soul voice within, possibly even unleashing your inner artist. No matter what inspires youSwift or notseek art that uplifts your soul.

As you do, you might find connection to the most pure impulse within to unlock your own mystical healingeven more so, with Mercury square Mars. Mercury represents analytical and communicative capacities, and is in Cancer, which rules the moon and represents cardinal water, which connects with emotions and the ability to self-nurture.

Mercury square Mars asks you to articulate the highest expression of your soul. In doing so, sadness may arise, as you recognize what needs to change or has already changed, as well as any losses you are still reconciling.

Mars represents dynamic action and accelerates opportunities for growth. Mercury square Mars asks you to articulate the highest expression of your soul. In doing so, sadness may arise, as you recognize what needs to change or has already changed, as well as any losses you are still reconciling. Remember, grief and pain are an important part of life. They are essential and a part of any spiritual awakening. While Marss position on Monday and throughout the entire week ahead is antagonistic, its important to lean into his antagonism. Let Mars provoke your yearnings, your drive, your determination, your feelings, and, most importantly, your passion.

As the week goes on, Mercury opposes Jupiter and Pluto, bringing more unseen and/or unintegrated emotions to the surface. Should insecurities arise, trust they are leading you to make choices that advance your healing. At the same time, Mercury will trine Neptune, bringing even more mystical vibes, unlocking your access to your own healing magic. Again, art, self-expression, and tuning into the voice of your soul are essential.

Come Friday, the sun in Leo trines Chiron in Aries. This is a very special moment. The sun in Leo asks you to tune into where you are meant to shine. Chiron in Aries asks you to look at the wounding that holds you back from self-expression. This combination of Mercury opposing Jupiter and Pluto while squaring Mars (forming a cardinal square), while trining Neptune, at the time of the sun in Leo trining Chiron in Aries, is particularly potent.

It invites you to reconcile the pain that keeps you from healing. It serves as a key to leveraging your own experiences to become more compassionate, kind, and capable of assisting others on their healing journey. Ultimately though, its about liberation. Its about forgiving the past, and finding new ways to be with the present moment. Its about accessing the courage within to self-express, stay compassionate towards others, and use your pain as an access point into your power.

The theme of the week ahead is awakening. As the sun shines, and the heat encourages growth, joy, and pleasure, let yourself feel, play and create. In doing so, you may just find yourself attuned to new heights of spiritual awareness.

Jennifer Racioppiis the creator of Lunar Logica philosophy that integrates the deep wisdom of both science and spirituality, and blends her expertise in astrology, positive psychology, and womens healthwhich she uses to coach high-achieving female entrepreneurs to reach their next level of success. Pre-order her book,Cosmic Health(January 2021), here.

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The Spiritual Theme Of the Week Ahead Is AwakeningHeres Exactly What To Expect - Well+Good

miRagen, Investigators from Goethe University and University Hospital Frankfurt and Servier Publish MRG-110 Phase 1 Pharmacodynamic Biomarker Data in…

FRANKFURT, Germany and BOULDER, Colo., July 28, 2020 (GLOBE NEWSWIRE) -- Goethe University, University Hospital Frankfurt and miRagen Therapeutics, Inc. (NASDAQ: MGEN), a clinical-stage biopharmaceutical company focused on the discovery and development of RNA-targeted therapies, today announcedthat preliminary results from a Phase 1 trial detailing the pharmacodynamic activity of MRG-110 has been published in the peer-reviewed journal Nucleic Acid Therapeutics.

We are pleased to have these Phase 1 mechanism of action results for MRG-110 published in Nucleic Acid Therapeutics, said William S. Marshall, Ph.D., President and CEO of miRagen Therapeutics, Inc. These data show that a single systemic dose of MRG-110 reduced detectable miR-92a levels in the peripheral blood of humans and led to the regulation of several well established miR-92a target genes.

The preliminary characterization of MRG-110 pharmacodynamic activity in the peripheral blood of humans provides important insight into the development of potential blood borne mechanistic biomarkers for miR-92a inhibition, added Prof. Dr. Stefanie Dimmeler, Director of the Institute for Cardiovascular Regeneration at the Center for Molecular Medicine, Goethe University Frankfurt. We believe these data provide the basis for further development of readily monitorable biomarkers that can be employed in future clinical trials.

The article, titled Efficiency and Target Derepression of Anti-miR-92a: Results of a First in Human Study, reports mechanistic results from a single ascending dose, double-blind, placebo-controlled, randomized Phase 1 clinical trial. The trial was a study where MRG-110 was administered systemically by intravenous dosing. miR-92a levels were measured in whole blood, circulating endothelial cells, and circulating extracellular vesicles before and after MRG-110 administration. miR-92a levels were found to be significantly reduced in all three of the sample types tested. Importantly, two miR-92a target genes were derepressed after treatment, indicating the intended mechanism of action of MRG-110 in normal healthy volunteers. These data may identify a strategy for measuring pharmacodynamic activity of MRG-110 in peripheral blood in future clinical trials. This would allow for monitoring the intended mechanism of action in blood samples during the conduct of clinical trials in patients, thereby providing an enhanced degree of confidence that the product candidate is affecting the biological pathway that is intended.

Work reported in the article was the result of a collaboration between Goethe University, University Hospital Frankfurt, miRagen Therapeutics and Les Laboratories Servier. Financial support for the studies was also provided by the German Centre for Cardiovascular Research (DZHK).

About miRagen Therapeutics, Inc.miRagen Therapeutics, Inc. is a clinical-stage biopharmaceutical company discovering and developing proprietary RNA-targeted therapies with a specific focus on microRNAs and their role in diseases where there is a high unmet medical need. miRagen has three clinical stage product candidates, cobomarsen, remlarsen, and MRG-110. miRagens clinical product candidate for the treatment of certain cancers, cobomarsen, is an inhibitor of miR-155, which is found at abnormally high levels in malignant cells of several blood cancers. miRagens clinical product candidate for the treatment of pathological fibrosis, remlarsen, is a replacement for miR-29, which is found at abnormally low levels in a number of pathological fibrotic conditions, including cutaneous, cardiac, renal, hepatic, pulmonary and ocular fibrosis, as well as in systemic sclerosis. MRG-110, an inhibitor of miR-92, is miRagens product candidate for the treatment of heart failure and other ischemic disease. In addition to these programs, miRagen is developing a pipeline of preclinical product candidates. The goal of miRagens translational medicine strategy is to progress rapidly to first-in-human studies once it has established the pharmacokinetics, pharmacodynamic, safety, and manufacturability of the product candidate in preclinical studies. For more information, please visitwww.miragen.com. For information on clinical trials please visitwww.clinicaltrials.gov.

About the University Hospital FrankfurtThe University Hospital Frankfurt, founded in 1914, is one of the leading academic hospitals in Germany. It offers its patients optimal medical care in 32 medical clinics / institutes. University hospital and faculty of Medicine together operate a total of 20 research institutes. The close connection to research ensures patients the prompt implementation of new knowledge in therapeutic practice. Around 1,500 inpatient as well as day clinic beds are available. Numerous institutes are dedicated to medical-scientific specialized services. Annually we take care of 51,000 inpatients and 227,000 outpatients. The University Hospital Frankfurt has special interdisciplinary competence amongst others in the fields of neuroscience, oncology and cardiovascular medicine. As a specialist for organ and bone marrow transplantation, dialysis and cardiac surgery, the clinic takes a special task of supra-regional medical care. Over 4,500 employees (full-time positions) take care of the patients around the clock.

About the German Centre for Cardiovascular Research (DZHK)The German Centre for Cardiovascular Research unites high-ranking scientists from all over Germany. It was founded in 2011 with the aim of bundling expertise in cardiovascular research and making it more effective so that research results can be transferred more quickly into clinical application. 1800 researchers from seven partner sites and 30 partner institutions, including university hospitals and non-university research institutions, are involved in the DZHK.

Note Regarding Forward-Looking Statements

This press release may contain forward-looking statements that involve substantial risks and uncertainties for purposes of the safe harbor provided by the Private Securities Litigation Reform Act of 1995. All statements contained in this press release other than statements of historical fact, including statements regarding miRagens strategy, anticipated clinical development milestones, prospects, plans and objectives of management are forward-looking statements. The words believe, may, will, estimate, continue, anticipate, intend, plan, expect, predict, potential, opportunity, goals, or should, and similar expressions are intended to identify forward-looking statements. Such statements are based on managements current expectations and involve risks and uncertainties. Actual results and performance could differ materially from those projected in the forward-looking statements as a result of many factors, including, without limitation: that miRagen has incurred losses since its inception, and anticipates that it will continue to incur significant losses for the foreseeable future; future financing activities may cause miRagen to restrict its operations or require it to relinquish rights; miRagen may fail to demonstrate safety and efficacy of its product candidates; miRagens product candidates are unproven and may never lead to marketable products; miRagens product candidates are based on a relatively novel technology, which makes it difficult to predict the time and cost of development and of subsequently obtaining regulatory approval, if at all; miRagens product candidates may cause undesirable side effects or have other properties that could delay or prevent the regulatory approval; and the results of miRagens clinical trials to date are not sufficient to show safety and efficacy of miRagens product candidates and may not be indicative of future clinical trial results.

miRagen has based these forward-looking statements largely on its current expectations and projections about future events and trends. These forward-looking statements are subject to a number of risks, uncertainties and assumptions, including those described under the heading Risk Factors in miRagens Annual Report on Form 10-K and subsequent periodic and current reports filed with the Securities and Exchange Commission. Moreover, miRagen operates in a very competitive and rapidly changing environment. New risks emerge from time to time.

It is not possible for its management to predict all risks, nor can it assess the impact of all factors on its business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements it may make. In light of these risks, uncertainties and assumptions, the future events and trends discussed in this press release may not occur and actual results could differ materially and adversely from those anticipated or implied in the forward-looking statements. miRagen undertakes no obligation to revise or publicly release the results of any revision to such forward-looking statements, except as required by law. Given these risks and uncertainties, readers are cautioned not to place undue reliance on such forward-looking statements. All forward-looking statements are qualified in their entirety by this cautionary statement.

Investor Relations Contact:Dan FerryManaging DirectorLifeSci Advisors617-430-7576daniel@lifesciadvisors.com

Corresponding Author: Prof. Dr. Stefanie DimmelerInstitute for Cardiovascular RegenerationCentre of Molecular MedicineGoethe University FrankfurtTheodor Stern Kai 7 60590 Frankfurt; GermanyPhone: +49-69-6301-5158 Fax: +49-69-6301-83462dimmeler@em.uni-frankfurt.de

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miRagen, Investigators from Goethe University and University Hospital Frankfurt and Servier Publish MRG-110 Phase 1 Pharmacodynamic Biomarker Data in...

Therapeutic Solutions International Files Patent on Ability of QuadraMune Ingredient Pterostilbene to Reduce Inflammation while Stimulating Brain…

OCEANSIDE, Calif., July 28, 2020 /PRNewswire/ --Therapeutics Solution International, Inc., (OTC Markets: TSOI), reported new data demonstrating that the blueberry derived compound pterostilbene possesses numerous brain protective and potentially brain regenerative activities. Pterostilbene is one of four ingredients which comprise QuadraMune, a nutraceutical being developed by the Company which is currently in a clinical trial for prevention of COVID-19. Information on the clinical trial can be found on the Government Clinical Trials website https://clinicaltrials.gov/ct2/show/NCT04421391.

"These new data confirm previous findings published on pterostilbene and also reveal novel therapeutic properties of this naturally occurring nutrient," said Dr. James Veltmeyer, Chief Medical Officer of the Company and Voted Top Doctor of San Diego. "By continually investigating mechanisms of action of our products, our ambition is to ensure we have support of the top medical and scientific leaders. In my opinion, many times, it does not matter how good your product is, what matters is that you have scientific basis for why it works. This is especially important in the current age of molecular medicine."

The data disclosed by the Company indicates:

a) pterostilbene suppresses inflammatory cytokines TNF-alpha, IL-1 beta and IL-6;

b) pterostilbene inhibits death of neurons caused by inflammatory mediators;

c) pterostilbene stimulates production of regenerative factors from cells in the brain such as BDNF, NGF, FGF-1, and FGF-2; and

d) pterostilbene allows/enhances proliferation of endogenous brain stem cells.

"The importance of possessing a deep scientific understanding of your product can be seen in the example of nutraceuticals which ended up obtaining regulatory clearance as drugs," said Timothy Dixon, President and CEO of Therapeutic Solutions International. "For example, Lovaza and Vascepa are both fish oil based products which have been developed scientifically and FDA approved through clinical trials. Lovaza, which is sold by GSK, had sales of approximately 1 billion per year and is used for reduction of triglycerides.1 Vascepa, sold by Amarin, had sales in 2019 of 410 million and is used to prevent heart attacks.2 We believe that similar developmental pathways may be possible with several of our existing products."

The Company is currently pursuing FDA clearance for its cell therapy produce StemVacs, for which an IND number was previously granted. The Company's in-licensed stem cell, the JadiCell has FDA clearance for other indications.

About Therapeutic Solutions International, Inc.Therapeutic Solutions International is focused on immune modulation for the treatment of several specific diseases. The Company's corporate website is http://www.therapeuticsolutionsint.com, our public forum is https://board.therapeuticsolutionsint.com/.

1 http://www.pmlive.com/pharma_news/teva_launches_first_generic_of_gsks_lovaza_in_us_5592732 https://www.fool.com/investing/2020/01/07/amarin-reports-preliminary-vascepa-sales-projects.aspx

Therapeutic Solutions International, Inc.[emailprotected]

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therapeuticsolutionsint.com

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Therapeutic Solutions International Files Patent on Ability of QuadraMune Ingredient Pterostilbene to Reduce Inflammation while Stimulating Brain...

AGC to Complete the Acquisition of MolMed on July 31, 2020 – PRNewswire

Cell and gene therapy is an innovative and rapidly growing therapeutic field that aims to treat diseases that do not have adequate treatments to date. Approximately 1,000 clinical trials are underway worldwide, with some products receiving market authorization in the last few years and approximately 50 new therapies expected to be authorized by 2030. Thanks to its two commercially authorized facilities, MolMed offers GMP services for the development and production of cell and gene therapies. MolMed brings deep experience and expertise in providing development and GMP manufacturing services for viral vectors and genetically modified cells, from the preclinical phase through commercial demand.

"While we work hard to take care of each other and our customers during this very challenging and uncertain time, it's also important that we ensure the continued growth of our company," says AGC Biologics CEO Patricio Massera. "AGC Biologics is committed to continuously expanding our offerings and growing our capacity to serve all the needs of current and future customers. We are very pleased to be adding MolMed and its great cell and gene therapy capabilities and track record to AGC Biologics' global CDMO service offerings."

About AGC Biologics:AGC Biologics is a leading global Contract Development and Manufacturing Organization (CDMO) with a strong commitment to deliver the highest standard of service to clients and partners. The company currently employs more than 1,000 employees worldwide. AGC Biologics' global network spans three continents, with cGMP-compliant facilities in Seattle, Washington; Boulder, Colorado; Copenhagen, Denmark; Heidelberg, Germany; and Chiba, Japan.

AGC Biologics offers deep industry expertise and unique customized services for the scale-up and cGMP manufacture of protein-based therapeutics, from pre-clinical to commercial mammalian and microbial production. Integrated service offerings include plasmid (GMP pDNA) manufacturing, cell line development, bioprocess development, formulation, analytical testing, antibody drug development and conjugation, cell banking and storage and protein expression, including the proprietary CHEF1 Expression System for mammalian production. Learn more at http://www.agcbio.com.

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AGC to Complete the Acquisition of MolMed on July 31, 2020 - PRNewswire

Novartis receives Piqray approval in Europe the first and only targeted medicine for HR+/HER2- advanced breast cancer with a PIK3CA mutation | Small…

DetailsCategory: Small MoleculesPublished on Thursday, 30 July 2020 13:55Hits: 588

BASEL, Switzerland I July 29, 2020 I Novartis today announced the European Commission (EC) has approved Piqray (alpelisib) in combination with fulvestrant for the treatment of postmenopausal women, and men, with hormone receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) locally advanced or metastatic breast cancer with a PIK3CA mutation after disease progression following endocrine therapy as monotherapy. Piqray is the first and only treatment specifically approved for people with advanced breast cancer whose tumors harbor a PIK3CA mutation, which stimulates tumor growth and is associated with poor response to therapy13.

Piqray is an important new therapy for HR+/HER2- advanced breast cancer patients whose tumors have a PIK3CA mutation, and we look forward to making it available in countries across Europe, said Kees Roks, Head Region Europe, Novartis Oncology. Knowledge of PIK3CA status can better equip doctors as they develop a personalized upfront treatment plan for patients. Piqray offers new hope for advanced breast cancer patients with a PIK3CA mutation, who typically face a worse overall prognosis.

This approval follows a positive opinion granted in May by the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) based on the Phase III SOLAR-1 trial showing that Piqray nearly doubled median progression-free survival (PFS) compared to fulvestrant alone1,2. Overall response rate, an indicator of the proportion of patients who experience at least a 30% reduction in overall tumor size (in patients with measurable disease), was more than doubled when Piqray was added to fulvestrant compared to fulvestrant alone1,2. Read more about the positive CHMP opinion and the SOLAR-1 clinical trial results here.

Patients with HR+/HER2- advanced breast cancer should be selected for treatment with Piqray based on the presence of a PIK3CA mutation in tumor or plasma specimens, using a validated test. If a mutation is not detected in a plasma specimen, tumor tissue should be tested if available.

About Piqray (alpelisib)Piqray is a kinase inhibitor developed for use in combination with fulvestrant for the treatment of postmenopausal women, and men, with HR+/HER2-, PIK3CA-mutated, advanced or metastatic breast cancer following progression on or after endocrine-based regimen. Piqray is approved in 48 countries, including the US and European member states.

Important Safety Information from the PIQRAY EU SmPC The most common ADRs and the most common grade 3 / 4 ADRs (reported at a frequency >20% and 2%, respectively) were plasma glucose increased, creatinine increased, gamma-glutamyltransferase increased, rash, lymphocyte count decreased, nausea, alanine aminotransferase increased, anaemia, fatigue, lipase increased, decreased appetite*, stomatitis, vomiting*, weight decreased, hypocalcaemia, plasma glucose decreased*, activated partial thromboplastin time prolonged*, alopecia**, diarrhoea, hypokalaemia, hypertension, nausea, creatinine increased, and mucosal inflammation (*<2% grade 3/4 ADRs reported, ** no grade 3/4 ADRs reported).

Piqray can cause serious side effects such as severe hypersensitivity, severe cutaneous reactions, hyperglycaemia, pneumonitis, diarrhoea, and osteonecrosis of the jaw.

The following should be taken into consideration prior to or during treatment with Piqray:

Piqray should be permanently discontinued in patients with serious hypersensitivity reactions.

Piqray should not be initiated in patients with a history of severe cutaneous reactions, should be interrupted if signs or symptoms of severe cutaneous reactions are present, and permanently discontinued if a severe cutaneous reaction is confirmed.

Fasting glucose and HbA1c levels should be monitored frequently in the first 4 weeks of treatment, and patients should be advised of the signs and symptoms of hyperglycaemia.

In case of new or worsening respiratory symptoms, the patient should be evaluated for pneumonitis.

Patients should be advised to notify their physician if diarrhoea occurs.

Caution should be exercised when Piqray and bisphosphonates or denosumab are used together or sequentially. Piqray should not be initiated in patients with ongoing osteonecrosis of the jaw.

The efficacy and safety of Piqray has not been studied in patients with symptomatic visceral disease.

Animal studies suggest that Piqray may cause fetal harm in pregnant women. Therefore, as a precaution, women of childbearing potential should use effective contraception while receiving Piqray during treatment and at least 1 week after stopping treatment. Women should not breast feed for at least 1 week after the last dose of Piqray. Piqray may affect fertility in males and females.

Please download full Summary of Product Characteristics for Piqray here.

About NovartisNovartis is reimagining medicine to improve and extend peoples lives. As a leading global medicines company, we use innovative science and digital technologies to create transformative treatments in areas of great medical need. In our quest to find new medicines, we consistently rank among the worlds top companies investing in research and development. Novartis products reach nearly 800 million people globally and we are finding innovative ways to expand access to our latest treatments. About 109,000 people of more than 140 nationalities work at Novartis around the world. Find out more athttps://www.novartis.com.

Novartis is on Twitter. Sign up to follow @Novartis at https://twitter.com/novartisnewsFor Novartis multimedia content, please visithttps://www.novartis.com/news/media-libraryFor questions about the site or required registration, please contact This email address is being protected from spambots. You need JavaScript enabled to view it.">This email address is being protected from spambots. You need JavaScript enabled to view it.

References1. Piqray (alpelisib) Prescribing Information. East Hanover, New Jersey, USA: Novartis Pharmaceuticals Corporation; May 2019.2. Andr F, Ciruelos E, Rubovszky G. Alpelisib for PIK3CA-Mutated, Hormone-Receptor-Positive Advanced Breast Cancer. N Eng J Med 2019.3. Globocan 2018 (WHO), Cancer Today: Estimated number of new cases in 2018, worldwide, females, all ages_1_ 2018.4. Gheorghe D. Breast Cancer. Decision Resources. July 2017:1-338.5. Tolaney S, Toi M, Neven P, et al. Presented at: 2019 American Association for Cancer Research (AACR) Annual Meeting; March 29-April 3, 2019; Atlanta, GA.6. Di Leo A, Johnston S, Seok Lee K, et al. Lancet Oncol. 2018;19(1):87-100.7. Moynahan ME, Chen D, He W, et al. Br J Cancer. 2017;116(6):726-730002E8. The Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature. 2012;490(7418):61-70.9. Sobhani N, Roviello G, Corona SP et al. The prognostic value of PI3K mutational status in breast cancer: a meta-analysis. J Cell Biochem. 2018;119(6):4287-4292.10. Sabine V, Crozier C, Brookes C, et al. Mutational analysis of PI3K/AKT signaling pathway in tamoxifen exemestane adjuvant multinational pathology study. Journal of Clinical Oncology. 2014;32:2951-2958.11. Miller TW, Rexer BN, Garrett JT, et al. Mutations in the Phosphatidylinositol 3-Kinase Pathway: Role in Tumor Progression and Therapeutic Implications in Breast Cancer. Breast Cancer Res. 2011.12. Saal LH, Johansson P, Holm K. Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity. PNAS. 2007;104(18):7564-7569.13. Thomssen, C., et al. (2020, February 10). International Consensus Conference for Advanced Breast Cancer, Lisbon 2019: ABC5 Consensus Assessment by a German Group of Experts. Retrieved June 16, 2020, from https://www.karger.com/Article/FullText/505957

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Novartis receives Piqray approval in Europe the first and only targeted medicine for HR+/HER2- advanced breast cancer with a PIK3CA mutation | Small...

The N-terminal domain of the androgen receptor is at the heart of its action – Baylor College of Medicine News

The androgen receptor binds to and mediates the effects of the androgenic hormone testosterone in both males and females. In both genders the androgen receptor regulates hair growth and sex drive. In males, it contributes to the development of sexual characteristics and, importantly, it drives the initiation and growth of prostate cancer, the second-leading cause of death in men.

At Baylor College of Medicine, Dr. Ping Yi, assistant professor of molecular and cellular biology, and her colleagues strive to achieve a better understanding of how the androgen receptor works in cancer by looking in great detail at the 3-D structure of the receptor.

Previous studies had shown that when the androgen receptor binds to testosterone, the resulting molecular complex travels to the cell nucleus where it interacts with DNA, turning genes on or off as necessary to regulate development and growth, Yi said.

To carry on its activity, the androgen receptor also binds to coactivators and other molecules that promote its gene-regulatory function. However, how all these molecules are put together in a functional complex with the androgen receptor was not known.

To treat prostate cancer effectively, we need to better understand how the androgen receptor works, said co-corresponding author Dr. Bert OMalley, chancellor and former long-time chair of the Department of Molecular and Cellular biology at Baylor. In this study, we reveal for the first time the complete 3-D structure of the active, full-length androgen receptor-coactivator complex as it interacts with DNA.

Before this study, researchers only had a partial idea of the 3-D structure of the androgen receptor. They were missing a part called the N-terminal domain, which biochemical evidence suggested might be crucial for its activity. Resolving the complete structure of the receptor would help understand why the N-terminal domain is key to the receptors activity.

Cryo-electron microscopy let us see what the N-terminal domain of the androgen receptor looks like, how the protein is organized and how this and other individual domains contribute to the coactivated protein and its function, said Yi, a member of Baylors Dan L Duncan Comprehensive Cancer Center.

The researchers discovered that the N-terminal domain at the beginning of the androgen receptor is where the coactivators bind, activating the complex that drives prostate cancer. This finding was in marked contrast with what the same researchers had discovered for the estrogen receptor, which is a major driver of breast cancer.

The androgen and the estrogen receptors belong to the same family of steroid nuclear receptors and share similar 3-D structures. However, despite having general structural similarities, in the estrogen receptor the coactivators bind not to the N-terminal domain at the beginning of the molecule, but to the C-terminal domain at the end of the molecule. This finding has important implications generating drugs for cancer treatment.

The androgen receptor drug inhibitors that are currently available for prostate cancer treatment bind to the C-terminal domain, which we found is not the main interactive site of the androgen receptor, OMalley said. Our work strongly supports further studies to determine the effect that drugs directed at the androgen receptors N-terminal domain have on prostate cancer growth.

Our study provides a starting point to understand what is happening to the androgen receptor molecular machine in prostate cancer, said co-corresponding author Dr. Zhao Wang, assistant professor in the Verna and Marrs McLean Department of Biochemistry and Molecular Biology. Our findings also generate a broader therapeutic space for the treatment of not only prostate cancer but also related diseases, as well as new information on basic mechanisms of regulation of gene expression.

Interested in learning all the details of this study? Find it in the journal Molecular Cell.

Other contributors to this work include co-first author Xinzhe Yu, Ross A. Hamilton, Hong Shen, Muyuan Chen, Charles E. Foulds, Michael A. Mancini and Steven J. Ludtke, all from Baylor College of Medicine.

This work is supported by NIH-NICHD and grants (HD8818, HD07857 and NIDDK59820, GM080139 and GM121203); DOD W81XWH-15-1-0536; CPRIT grant (RP150648); the Robert Welch Foundation (Q-1967-20180324 and BCM BMB department seed funds). Further support was provided by NCI Cancer Center Support Grant P30CA125123 (BCM Monoclonal Antibody/Integrated Microscopy Core/Recombinant Protein Expression Core Facility) and the Cryo-EM supported by Advanced Technology CPRIT Cryo-EM/ET Core (1RP190602) at BCM.

By Ana Mara Rodrguez, Ph.D.

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The N-terminal domain of the androgen receptor is at the heart of its action - Baylor College of Medicine News

Neanderthal Gene Linked to Increased Pain Perception | Present – Explica

Neanderthal life was not easy. Ice age hunter-gatherers barely survived throughout western Eurasia, hunting mammoths, bison, and other dangerous animals.

Now, a pioneering study of its genome, published in Current Biology, reveals that, despite their harsh existence, Neanderthals had a biological predisposition to perceive pain more intensely. Evolutionary geneticists discovered that these ancient human relatives carried three mutations in a gene that codes for the NaV1.7 protein, which transmits painful sensations to the spinal cord and brain. They also showed that, in a sample of British citizens, those who had inherited the Neanderthal version of NaV1.7 often feel more pain than others.

For me, it is a first example of how we started to get a possible idea about Neanderthal physiology taking current people as transgenic models as a reference, says Svante Pbo, from the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, who led the study. with Hugo Zeber of the Karolinska Institute in Stockholm.

A protein related to pain perception

The researchers have had access to only a few Neanderthal genomes, and most of them have been sequenced at low resolution. This has made it difficult to identify mutations that occurred after their lineage separated from that of todays humans, between 500,000 and 700,000 years ago. But in recent years, Pbo and his team have obtained three high-quality Neanderthal genomes from DNA found in caves in Croatia and Russia. This has allowed them to identify mutations that were surely very common in Neanderthals, but are very rare in humans today.

Mutations in a gene called SCN9A which codes for the NaV1.7 protein persisted because all Neanderthals had three mutations that altered the shape of the protein. The finding of the mutated form of the gene in both sets of chromosomes in the three Neanderthals indicates that it was common in all their populations.

NaV1.7 acts on the nerves in the body, controlling the extent to which pain signals are transmitted along the spinal cord to the brain. They have described it as a kind of volume control, which determines the amount of pain transmitted by nerve fibers, says Zeberg. Some people who have extremely unusual gene mutations that turn off the protein do not feel pain, while other changes may predispose people in question to suffer from chronic pain.

To investigate how mutations may have altered Neanderthal nerves, Zeberg introduced his version of NaV1.7 in frog eggs and human kidney cells useful model systems for characterizing the proteins that control nerve impulses. The protein was more active in cells that had all three mutations than in cells that had not undergone those changes. In nerve fibers, this could lower the threshold from which a painful signal would be transmitted, says Zeberg.

He and Pbo then searched for humans with the Neanderthal version of NaV1.7. About 0.4 percent of participants in the Britains biobank, a database of the genomes of half a million Britons, who claimed to have painful symptoms, had a copy of the mutated gene. No one had two, as was the case with Neanderthals. Participants with the mutated version of the gene were 7 percent more likely to experience pain in their daily lives than people without it.

Sensitive Neanderthals

It is a beautiful job, because it shows how some aspects of Neanderthal physiology can be reconstructed by studying modern humans, says Cedric Boeckx, a neuroscientist who works at the Catalan Institution for Research and Advanced Studies in Barcelona, Spain. In a 2019 study, Boeckx noted three other proteins involved in pain perception that are different in modern humans and Neanderthals. Those changes may be evidence of differences in resilience between the two species, Boeckx says.

Pbo and Zeberg caution that their findings do not necessarily mean that Neanderthals would have felt more pain than modern humans. The sensations transmitted by NaV1.7 are processed and modified in the spinal cord and in the brain, which also contributes to the subjective experience of pain.

Gary Lewin, a neuroscientist at the Max Delbrck Center for Molecular Medicine in Berlin, points out that Neanderthal variants have little influence on the function of NaV1.7 let alone other mutations that are associated with chronic pain. It is hard to imagine why a Neanderthal would want to be more sensitive to pain, he adds.

It is not clear if the mutations evolved because they were beneficial. Neanderthal populations were made up of few individuals and their genetic diversity was low conditions that can help harmful mutations persist. But Pbo believes that change smells like a product of natural selection. So he plans to sequence the genomes of about a hundred Neanderthals, which could help provide some answers.

In any case, pain is adaptive, says Zeberg. It is not particularly bad to feel pain.

Ewen Callaway

Reference: A neanderthal sodium channel increases pain sensitivity in present-day humans, by H. Zeberg et al., In Current Biology, published on July 23, 2020.

Article translated and adapted by Research and Science with permission from Nature Research Group.

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Neanderthal Gene Linked to Increased Pain Perception | Present - Explica

Headaches, memory loss and extreme fatigue among long-lasting symptoms of COVID-19 – The Owensboro Times

Graphic by Owensboro Times

Four months into the coronavirus outbreak in the U.S., people that tested positive for COVID-19 are still experiencing life-changing effects.

Bathing, cooking or washing clothes have become challenging tasks for some survivors, and patients seemingly recovered from the virus have returned to the hospital weeks later with a stroke or heart attack.

Theyre noticing that walking upstairs is hard when they used to be a runner, said Dr. Rebecca Dutch, virologist and chair of the University of Kentuckys Department of Molecular and Cellular Biochemistry, who is helping coordinate the universitys COVID-19 research.

These long-term symptoms are happening widely across the globe and are affecting both younger and older adults. Last week, the Centers for Disease Control and Prevention suggested, based on a new survey, that COVID-19 can result in prolonged illness in young adults without underlying chronic medical conditions.

About one-third of adults with positive outpatient test results and about one in five adults aged 18-34 with no chronic medical conditions had not returned to their usual state of health two or three weeks after testing.

Data from the COVID Symptom Study app, created by researchers at Kings College London, revealed that about 10 percent of the nearly four million people contributing to the app had effects lasting more than four weeks.

Its becoming clearer that there are long-term residual effects, said Dr. Todd Rice, a critical care medicine specialist and pulmonologist at Vanderbilt University Medical Center who has been treating COVID-19 patients since early March.

Muscle aches, difficulty breathing, headaches, difficulty concentrating, memory loss and coughs have been widely reported lingering symptoms. There have also been accounts of heart palpitations, night sweats, hair loss and rashes.

Chronic fatigue is possibly the most common debilitating impact, and it seems to be more prolonged than what has been previously seen from viral infections.

This just seems to go on much longer, said Rice, who has patients that contracted the virus in March that are still not recovered. It just wears people out. They just dont have energy.

There have also been reports of young children developing a post-inflammatory syndrome, called multisystem inflammatory syndrome, after contracting the virus. It affects multiple organs, such as the kidney, liver, heart, lungs and brain, and can cause symptoms like breathing problems, confusion and delirium, according to Rice, who added that it was rare in adults.

Anybody can get it. Anybody can get really, really ill, and anybody can get these long-term effects from it, Rice said. If youre young, and have 50 years left in your life, youre going to want to avoid this so you dont have 50 years of lingering effects.

COVID-19 impacts many parts of the body. For most individuals, the effects might appear as a fever, cough or loss of smell. But there could also be abdominal pain, diarrhea, or swelling in the fingers or toes.

When you get millions of people infected, even if something is quite a rare event, you will start to see it, Dutch said.

But further investigation is needed to understand the long-term symptoms, how prevalent they are and whats causing them. Research is also needed to help determine how to prevent the symptoms or lessen and shorten the duration of effects.

The hard part is that its likely that the treatments will need to be done before the lingering symptoms start, Rice said, as opposed to addressing the symptoms after they appear.

Research indicates that the long-lasting symptoms could be from damage to the body during the illness or an immunological response after the initial disease.

Its possible that some symptoms could result from a lingering viral infection. Most patients test negative several weeks after contracting the virus, but there have been rare cases of people testing positive for several months.

With limited data and observations, many questions remain unanswered.

Were just now starting to understand these longer-term effects, Rice said. What are the real long-term effects, a year or two down the road? We dont know yet.

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Headaches, memory loss and extreme fatigue among long-lasting symptoms of COVID-19 - The Owensboro Times

Imaging accreditation org RadSite announces new CMO, and other recent radiology job changes – Health Imaging

Radiology Partners president steps down

Jay Bronner, Rad Partners first-ever CMO announced Wednesday that he will be stepping down as president of the El Segundo, California, imaging provider.

When I joined RP, my colleagues and I aspired to build the leading radiology practice in the country, he said in a statement. Now, reflecting on everything thats been accomplished, Id say weve achieved that goal in many ways.

As of this month, Bronner moved into a part-time position, and said he is not seeking a new position elsewhere. The imaging giant also said it will be evaluating the vacated role over the next few months.

Radiology Business has more on the recent decision.

ACR names new director of policy institue

The American College of Radiology named Elizabeth Y. Rula, PhD, the new executive director of the Harvey L. Neiman Health Policy Institute. She will oversee Neiman HPIs efforts to advance evidence-based imaging policy, the ACR announced earlier this month.

Rula has more than a decade of healthcare leadership experience, most recently as executive director of research and thought leadership at Tivity Health. She succeeds Danny Hughes, PhD, who led the institute since its beginnings in August 2012. Read more here.

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Imaging accreditation org RadSite announces new CMO, and other recent radiology job changes - Health Imaging

Coronavirus Many specialists now advocate the usage of masks: The protecting impact is giant and statistically important – Pledge Times

Finland there is a heated debate about face masks. With most of the Nordic countries, Finland is one of the few places in the world where no general face mask recommendation or compulsion has been issued.

Of the Nordic countries, Iceland said on Thursday that it would tighten measures against the spread of the coronavirus. For the first time in Iceland, a mask obligation will be introduced on public transport, domestic flights, ferries and hairdressing salons.

The new restrictions will take effect on Friday and will last for at least two weeks.

Most countries in the world has introduced a mask compulsion or at least a recommendation to use a mask in public places to combat a coronavirus pandemic.

In June, the World Health Organization (WHO) changed its recommendation on the use of the mask. The WHO now recommends the mask for use in public transport, workplaces and grocery stores, for example.

Finland no general mask recommendation or compulsion has been issued throughout the period of the coronavirus epidemic. In healthcare, masks are used, and by individual actors such as the airline Finnair and University of Tampere, have prescribed mask packs.

The Government has not issued a general recommendation on the use of a face mask. In the fight against the coronavirus epidemic, the Finnish government recommends, among other things, keeping safety gaps, coughing up a sleeve or handkerchief, washing hands diligently and paying attention to people at risk.

The position of the National Institute for Health and Welfare (THL) has not changed during the epidemic. THLs website still reads, there is no evidence that extensive use of the mask in healthy individuals would help reduce infections.

Also, according to the WHO, scientific research still does not clearly show how much the widespread use of masks by ordinary people would be. However, the recommendation was amended because experience has been gained in different countries with the benefit of the mask, especially when it is not possible to maintain safety distances.

Finland mask recommendation or coercion has been put down especially for such situations. Assistant Chief Physician, Department of Infectious Diseases, Helsinki and Uusimaa Hospital District (Hus) Eeva Ruotsalainen recalls that safety gaps do not work, for example, on public transport.

Thats when the face mask provides protection to prevent the spread of the epidemic, as the disease mainly spreads by inhalation. Therefore, a face mask is able to combat the epidemic. I recommend it in congestion areas and I also hope for a national recommendation, especially if the incidence of the disease starts to increase, says Ruotsalainen.

Huss director of diagnostics Lasse Lehtonen is on the same lines as the Swede.

I think the recommendations of the WHO and the European Office of Communicable Diseases are good and up-to-date. They recommend using masks in situations where distances cannot be maintained. It is justified to use them in public transport, for example. In Finland, it would be good to practice it on trains, buses and metros.

However, Lehtonen is not any proponent of mask coercion.

They should be available and a social pressure should be created where they would just start to be used. With people now returning to work, its pretty hard to keep their distance on the subway and buses. In that sense, the mask recommendation would be quite justified, says Lehtonen.

On Friday Hanna Ollila and Liisa Laine wrote in HSs Guest Pen writing that their study found that face shields reduce the risk of a respiratory infection by a third.

The protective effect is large and statistically significant. Masks are most useful when combined with safety gaps and hand washing. Ollila and Laine write.

We propose that a mask recommendation be introduced in Finland, especially in areas of active epidemics and in public transport, together with good hand hygiene, avoidance of close contact and testing and tracing.

Ollila is a team leader at the Finnish Institute of Molecular Medicine at the University of Helsinki and a researcher at Stanford University in the United States. Laine is a postdoctoral researcher at the Leonard Davis Institute of the University of Pennsylvania, USA.

Virus Infectious Status has remained stable in Finland. During the last follow-up week (20-26 July), 51 cases were reported to the Communicable Diseases Register, THL. During the week, an average of four thousand coronavirus tests were performed per day.

Number of tests has risen since June.

Assistant Professor of Threatening Infectious Diseases at the University of Helsinki Tarja Sironen stated In an interview with HS last weekthat although the situation is good in Finland, it is still bad in the world.

Once the borders are open, it is clear that there will be more cases. Maybe it would be good to learn how to use a mask, get them at home and watch how the situation changes, Sironen estimates.

According to Husin Lehtonen, the mask recommendation is also about educating the attitude of the population:

Finland does not have the same attitude to the use of masks as, for example, in Asian countries. Its a new thing for us, but we also learned to use our hands quickly and we would certainly learn masks if we just started practicing, says Lehtonen.

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Coronavirus Many specialists now advocate the usage of masks: The protecting impact is giant and statistically important - Pledge Times

Astronomers Say "Megaripples" Are Moving Across the Surface of Mars – Futurism

Researchers have found evidence of gigantic waves of sand, often referred to as megaripples, slowly moving around on the surface of Mars, as Science reports.

Megaripples arent unique to Mars; they can be found in deserts back here on Earth as well. But the Red Planets colossal sand dunes, believed to have formed hundreds of thousands of years ago, could be a sign that winds on Mars are even stronger than previously believed.

In a paper published last month in the Journal of Geophysical Research: Planets, the team suggests that megaripples may be migrating thanks to small grains of sand knocking into larger grains, dragging them into motion.

The new research goes against current atmospheric models that largely suggest winds couldnt be strong on Mars enough to move these mega sand structures. In other words, a thin atmosphere may allow for surprisingly strong winds.

Using images taken by NASAs Mars Reconnaissance Orbiter, the international team of scientists had a closer look. By focusing on two sites near the Martian equator, they analyzed a total of 1,100 megaripples.

Scientists previously believed that these megaripples on the Red Planet were first formed a long time ago, when a thicker atmosphere allowed for much heavier winds, and were now stationary.

But to their astonishment, they found that the megaripples do in fact appear to move albeit at the slow paceof roughly 10 centimeters per Earth year. According to Science, thats about as fast as megaripples in the Lut Desert in Iran.

The surprising takeaway: Winds could be strong enough after all, despite the thin Martian atmosphere. A past climate with a denser atmosphere is not necessary to explain their accumulation and migration, the team concluded in their paper.

And thats bad news for future astronauts visiting the Red Planet, as windy conditions could end up messing with habitats and solar panels.

Nonetheless, its an astonishing new discovery about our planetary neighbor.

We can now measure processes on the surface of another planet that are just a couple times faster than our hair grows, Ralph Lorenz, a planetary scientist at the Johns Hopkins University Applied Physics Laboratory, who was not involved in the study, told Science.

READ MORE: Giant waves of sand are moving on Mars [Science]

More on Mars: NASAs Next Rover Will Bring First-Ever Microphone to Mars

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Astronomers Say "Megaripples" Are Moving Across the Surface of Mars - Futurism

Amazon And Tesla Versus 885 Cheap Stocks – Forbes

Mr. $74 billion

Have hot Nasdaq NDAQ giants gotten too hot? Maybe its time for small, boring companies to catch up.

It has been a glorious time for big, glamorous companies. The Vanguard Growth fund, which owns favorites like Microsoft MSFT , Amazon AMZN and Tesla TSLA , has delivered a 25% return over the past year.

It has been a rotten time for small and uninteresting companies. The 12-month return for Vanguard Small-Cap Value, which mostly owns slow-growing outfits that you have never heard of, is -15%.

You expect value companies to go in and out of favor and small companies to go in and out of favor. Either could beat or lag the market a little. But this is a 40-point differential. The divergence in returns between large growth and small value is freakish.

It is possible that big growth stocks have gotten too expensive and small value stocks too cheap. If you want to make a bet that this is the case, you would move money out of big growth stocks and into the shares of small companies trading at low multiples of earnings or book value. Youd be fighting the tape. But you might be vindicated in a big way over the next several years.

Fair warning: Fans of value investing, myself included, have been predicting its resurgence for quite a while, and have come away disappointed time and again. Research Affiliates, a money manager in Newport Beach, California, sums up their despair in a recent white paper. Value has been underperforming growth since 2007, says the report, an extraordinarily long losing streak.

Only part of this underperformance is related to the earnings disappointments of value companies like oil producers. Most of it, say the papers authors (among them, RA founder Robert Arnott), can be blamed on the ever-larger premiums the market bestows on growth companies. Indeed, the disparity in valuation between growth and value is at an historical extreme, near the 100th percentile level.

No question that Tesla deserves to be trading at a higher multiple of its book value than Bank of America BAC . But how much higher? The price/book ratios for these two are 27 and 0.9. Quite the spread.

At some price point good companies cease to be good investments, and unattractive companies cease to be bad investments. The Research Affiliates analysis suggests that we have reached that point, that its time to favor value.

The size factor, another driver of stock market performance historically, is also acting out of character. Over long stretches in the past century, small-company stocks have beaten big-company ones. But that pattern is now disrupted. In the past decade small stocks have lagged the big-company S&P 500 index.

Time for the little stocks to catch up? Research Affiliates thinks so. The market seers there are a bit pessimistic about U.S. equities, but less pessimistic about small companies than big ones. They project an annual 4.7% return, including dividends, on small stocks (2.7% after inflation), 2.5% on big ones (0.5% after inflation).

The last 13 years have been utterly baffling to academic researchers, who thought they had it all figured out. There were certain factors, they theorized, that led to excess returns. Value was one and small size another.

For both of these factors, there was a persuasive explanation. It was possible for value stocks to do better than growth stocks over the long haul because investors, with vivid memories of stars like Amazon and not such lasting memories of flops like Webvan, overpaid for growth. The theory on the small stocks winning out over time is that they are risky and illiquid and so investors have to be rewarded for putting up with them.

Buy small, buy valueit worked for a long while. Kenneth R. French, a professor at Dartmouths business school and a prominent theorist about factor investing, publishes performance data for subsets of the market. In one of his tables the stock universe is carved into five subsets of size (measured by market capitalization) and five quintiles of value (measured by price/book ratios). Take a look at the stocks falling in both the smallest cap group and the highest value (lowest price/book) quintile. If you had bought these and constantly updated your portfolio you would have, in the span of 80 years ended in December 2006, turned $1 into $420,000.

On paper, that is. No one did this, and anyone who tried would have confronted bid/ask spreads cutting deeply into the supposed returns. (Those little value companies had tiny capitalizations, making it expensive to get in and out of positions.) Still, even allowing for the theoretical nature of this exercise, one concludes that there must have been something powerful going on with these size and value factors.

The 42,000,000% return comes to an annualized 17.6%, just about double the 9.4% seen in the diagonally opposite corner: big companies trading at high price/book ratios. A high price/book ratio doesnt equate to growth precisely, but its a good proxy. It would have meant buying Coca-Cola KO rather than some casket company.

And then, beginning in 2007, the tables turned. In the 13 calendar years since, big growth has walloped small value, 11.5% a year to 5.3%.

Maybe small values 80-year streak was a fluke, irrelevant to a digital economy. In which case you ignore it.

Or maybe theres something eternal at work, and small value is aching to reassert itself. There are two good ways to bet on this. Both are cheap funds, my favorite things to buy.

One is Vanguard Small Cap Value, ticker VBR. With this portfolio you are bypassing Amazon at 141 times annual earnings and Tesla at 217 times. Instead you own Sonoco Products SON , which costs 17 times earnings and is a leader in reels and spools. You own Steel Dynamics STLD , which costs 13 times and gets its dynamism from bundled scrap. You own 883 other stocks. Net of securities lending income, the funds expenses come to 0.02% of assets annually.

The other is a small-company fund with a more subdued tilt to value: Schwab Fundamental U.S. Small Company Index, ticker SFSNX. The index, designed by Arnotts Research Affiliates, weights 939 companies not by their market values but by a combination of three fundamentals: cash flow, sales and distributions (the sum of dividends and buybacks). Rather than exclude fast growers it just gives them a smaller spot than they would command in the usual market-value-weighted fund. Holdings include Range Resources RRC , a money-losing natural gas producer, and CoreLogic CLGX , a massager of real estate data. This funds expenses, net of sec lending, run to 0.19% annually.

Both of these funds failed to keep up with the bull market of the past decade. I expect them to outperform a weaker stock market in the coming decade.

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Finally Today’s Tim arrives in virus-free holiday haven – Noosa News

Today Show weatherman Tim Davies has not been under a rock all his life but he admitted to being a first timer to Noosa as he live-crossed to the nation from Main Beach with a backdrop to cure any COVID-19 lockdown blues.

It makes my job really easy, you dont need to say too much, said the veteran journo, you just let the pictures sell it. We certainly did that this morning.

Tim and his crew had mail-order perfect Queensland winter conditions for his first of a three-day stay organised with the help of Tourism Noosa to feature Noosa River tomorrow and the hinterland Thursday.

This is my very first time to Noosa as I said to someone this morning on the boardwalk, he said.

She kind of looked at me as if I had three heads she wanted to know if I had been living under a rock or something.

Today Show's Tim Davies about to thrill ride and meet dolphins at Sunshine Beach.

Ive done other parts of the Sunny Coast, but Ive never made my way to Noosa but its been one of those places on the bucket list and its good to finally get here.

He said Laguna Bay presented perfectly for the TV viewers without a breath of wind.

We had a drone up and there were gasps coming from the control room from everyone back in wet old Sydney, Tim said.

They were very jealous.

The morning featured some beach yoga, and Tim hung out with a couple of local icons we had the Mercers (lifesaving father and daughter talents Darren and Jordan) down there so that was nice.

Another guest was master surfboard shaper turned Noosa councillor Tom Wegener, while Peter Kurivita of the Noosa Beach House dropped in to cook a pretty special breakfast of baked eggs that were unreal.

On arrival Monday he broke the ice with a Noosa Ocean Rider induction on the water at Sunshine Beach.

We had a huge pod of dolphins come past and they were flapping around us. It was just incredible, Tim said.

Today Show weatherman Tim Davies receives some surfboard shaping history lessons from Cr Tom Wegener.

Unlike some southerners Tim had no hassles when it came to arriving in Noosa, because he has been basically a Queensland refugee cooling his heels here for weeks as part of a Today Show directive.

This was after he had earlier this year gone into a two-week quarantine forced by returning to Australia after a skiing holiday just before the international borders closed.

That was 10th/11th March when COVID really started to take hold. We were in the third flight that landed in Sydney but ScoMo had ordered only home isolation at that stage, Tim said.

You have to take it seriously, my biggest concern now is complacency.

Queensland is COVID-free, but thats not excuse to be shaking hands and high-fiving, you just never know whos snuck over that border.

Tim said hes been in Queensland for three-and-a-half-weeks after arriving in Cairns on assignment when his boss called from Sydney telling him to stay north for the foreseeable future.

Im here for a while, I have no idea how long that will be.

Hell gratefully accept being a temporary Queenslander providing he does not have to wear the Maroon jersey.

After leaving the Hastings St precinct, Tim and his crew were headed up to Double Island Point four-wheel driving to take in the Coloured Sands.

Its magic job to have. I hope to sustain it as long as I can, because living out of a suitcase on the road does take a toll after a while, Tim said.

Its not always about glamour, but it is such a blessing to be able to get out and meet people and hear their stories, and showcase different regions.

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Faculty/staff honors: Women in engineering network nod, winning magazine article on geologic hazards and refugees and two national genetics society…

Health and medicine | Honors and awards | UW and the community | UW Notebook

July 28, 2020

Recent honors to University of Washington faculty and staff members have come from the Women in Engineering ProActive Network, Association Media & Publishing and The American Society of Human Genetics.

Sociologist Elizabeth Litzler honored by national network promoting women in engineering

Elizabeth Litzler

The Women in Engineering ProActive Network, or WEPAN, has given its 2020 Founders Award to Elizabeth Litzler, UW affiliate assistant professor of sociology and director of the UW Center for Evaluation & Research for STEM Equity.

The award, one of several given annually, is given to a network member who exemplifies the spirit of the WEPAN founders through her extraordinary long-term service to the organization.

The network is a national professional society that uses research and best practices to promote the inclusion of women in the field of engineering. Its members work to connect advocates across North America to increase the participation, retention and success of women and other under-represented groups in engineering from college to executive leadership.

Litzlers and other 2020 WEPAN awards will be presented at the networks next annual conference, planned for January 2021.

* * * Article by Joseph Wartman, Will Pollock of civil and environmental engineering wins award from media group

Joseph Wartman

Professor Joseph Wartman and doctoral student Will Pollock of the UW Department of Civil & Environmental Engineering have won a silver EXCEL Award from Association Media & Publishing for a feature magazine article they co-wrote on geologic hazard risks toSyrian and other refugees.

Their non-technical article was titled No Place to Flee and was published in November 2019 in the American Geophysical Unions journal EOS. Wartman is the H.R. Berg Professor of Civil & Environmental Engineering.

Association Media & Publishing AM&P for short gives out annual bronze, silver and gold EXCEL Awards for books, digital media, journals, magazines, newsletters, newspapers and promotional content. The awards recognize excellence and leadership in association media, publishing, marketing and communications.

* * *

UW Medicines Mary-Claire King, Peter Byers honored by American Society of Human Genetics

The American Society of Human Genetics has honored two UW Medicine faculty members Dr. Mary-Claire King and Dr. Peter Byers with 2020 awards.

Mary-Claire King

King was chosen to receive the societys 2020 William Allan Award, which recognizes substantial and far-reaching scientific contributions to human genetics. The award is named for one of the first American physicians to extensively research human genetics and hereditary diseases. The award comes with a $25,000 prize.

King is the American Cancer Society Professor of Medicine and Genome Sciences, and an affiliate member of the Fred Hutchinson Cancer Research Network.

The societys president, Anthony Wynshaw-Boris of Case Western University, praised King for providing insight into the existence of the gene she named BRCA1, and changed our understanding of cancer prevention and treatment. Read more from the UW Division of Medical Genetics.

Peter Byers

The genetics society, also called ASHG, chose Byers for its 2020 Victor A. McKusick Leadership Award, which is given annually for exemplary leadership and vision by promoting genetics and genomics knowledge in the broader scientific community.

The award, which comes with a $10,000 prize, recognizes the importance of Byers research on the molecular pathogenesis of inherited disorders of connective tissue, and for his leadership in nearly all facets of the societys work. Byers has served as the societys president and editor of its American Journal of Human Genetics. Read more on the UW Division of Medical Genetics website.

The society was founded in 1948 and its 8,000 members include researchers, academics, clinicians, laboratory practice professionals, genetic counselors and nurses. The awards will be presented at the next annual meeting, to be held virtually and not yet scheduled.

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Faculty/staff honors: Women in engineering network nod, winning magazine article on geologic hazards and refugees and two national genetics society...