Valley of the Flowers Peace Prize awarded to Lompoc Black Lives Matter organizers – Lompoc Record

The five leaders named, Anthony Vickery, 21, Kongie Richardson, Keith Joseph, 24, Raelyn Person, 23, and Jason Bryson, were responsible for organizing one of Lompoc'slargestdemonstrations for social justice following the killing of George Floyd, an unarmed Black man who died after a Caucasian police officer in Minneapolis knelt on his neck for more than eight minutes on Memorial Day.

The death of Floyd, an unarmed Black man who died after a police officer in Minneapolis knelt on his neck for more than 8 minutes on Memorial Day, sparked a national response that also shook Lompoc.

The June 2 protest, which drew hundreds of participants from various racial, religious and political backgrounds, remained peaceful, according to officials, who reported that no vandalism occurred.

Both Joseph and Vickery, on behalf the their group, thanked prize sponsorsValley of the Flowers United Church of Christ, and Vickery acknowledged all the nominees for their own community outreach and acts of kindness.

"It goes beyond the award just knowing that the community can come together when it wants to," Vickery said. "Everybody is so scared to make that change, but once one person does it, it's like a ripple effect. Things can happen."

Joseph explained that although brutality is nothing new, for him the death of Floyd tookmore time to process.

"To watch someone dieslowly on camera," Joseph said, "that one was different."

In contrast to focusing on Black lives solely, Joseph said the group's efforts were meant to benefit the community as a wholeand serve as a powerful reminder that the nation's not-too-distant history was plagued by racial segregation.

While the aim to improve mental health resources for local schools remains central to his campaign, Murkison, who is Black, said he also hopes to cast a wider net on youth representation and diversity while serving on the school board.

"We just spoke from the heart," he said, recalling the intensity of the protest and the many challenges of organizing it. "It wasn't just Black lives; it's just wanting to help the community."

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Valley of the Flowers Peace Prize awarded to Lompoc Black Lives Matter organizers - Lompoc Record

A man in Illinois pleaded guilty to inciting a violent riot in support of Black Lives Matter – Insider – Insider

A man in Illinois pleaded guilty on Tuesday to his role in inciting a riot in Champaign, Illinois, according to the US Department of Justice.

Shamar Betts, 20, was charged with inciting a riot that began on May 31, 2020. Court documents show Betts posted to Facebook on May 31 advocating to start a riot at the Market Place Shopping Center in the names of George Floyd and Black Lives Matter. It called for people to "Bring friends & family, posters, bricks, book bags, etc."

A Facebook post from Shamar Betts on May 31, 2020 calling for a riot in Champaign, Illinois. Department of Justice

Court records show SWAT team officers with crowd-control substances arrived early to the scene in an effort to prevent a riot from taking place. The crowd grew in size as 50 to 75 people trickled into the location before people began smashing windows and looting inventory from stores.

As the riots continued, federal prosecutors allege that Betts live-streamed the incident and bragged to the stream, saying "look what a n----r just started."

Court filings show that the riots began at 3:12 p.m. and later left the shopping center to move to other locations. According to the News-Gazette, a newspaper in the Champaign-Urbana metropolitan area, the mayor of Champaign announced a curfew during the riots in an effort to curb the rioting.

Read more: The George Floyd protests may become a defining moment in the future of American politics

Despite the new curfew, the rioting ultimately continued throughout the night and into the early morning of June 1. By riot's end, approximately 50 businesses had been looted or vandalized in some form.

George Floyd's family denounced the rioting and unrest the same day. Terrence Floyd, George's brother, said: "That's not going to bring my brother back," and urged people to channel their frustration into voting and peaceful activism instead.

The Champaign Police Department later received video footage of a man matching Betts' appearance with several pairs of khaki pants in hand with tags from Old Navy, a clothing store located in the mall.

Betts admitted in court that he fled to Mississippi directly after the riot and later used his phone to search "can police find your location by logging in messenger," "can police track your facebook," as well as "what are charges for starting a riot." US Marshals found Betts in Mississippi on June 5.

According to a sworn affidavit from Special Agent Andrew Huckstadt of the FBI, Betts deleted the original post advocating for a riot, but investigators found an additional post from Betts where he wrote "They tryna portray me to be some type of monster yet I'm a fucking hero if we don't stand for something we'll fall for anything love my black people #JFG."

Betts' sentencing is scheduled for June 14. The statutory penalty for inciting a riot is no more than five years in prison, three years of supervised release, and a fine of up to $250,000.

Betts' attorneys were not available for public comment.

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A man in Illinois pleaded guilty to inciting a violent riot in support of Black Lives Matter - Insider - Insider

How Black Lives Matter Came to the Academy – The New Yorker

On a Saturday night in early June, Shard Davis, an assistant professor in the Department of Communication at the University of Connecticut, was sitting on a couch in a rented apartment in San Diego, scrolling through her Twitter feed. She was in California to do research on a project that was funded by a Ford Foundation postdoctoral fellowshipplans that had been affected somewhat by COVID-19 and the widespread protests for racial justice. Davis herself had gone to a Black Lives Matter protest in La Mesa the previous weekend. The event had started out peacefully but turned ugly when California Highway Patrol officers squared off with thousands of protesters on the I-8 freeway. There were reports of bottles thrown, tear gas unleashed, arson, and looting.

A week later, after attending another protest, Davis still couldnt calm down. As she sat alone on her couch, ruminating about the murders of George Floyd and Breonna Taylor and news coverage of the La Mesa protestthe crowd had been mostly white and Latinx, she said, but the media made it seem as though Black folks were the ones destroying propertyshe felt more and more enraged.

She asked herself repeatedly, What can I do? She was already thinking about what it would look like for universities to cut ties with police departments. I think I was just drawing the very obvious connections, she said. Academia is seen as a very liberal and progressive place, but systemic racism is running through all of these different institutions.

Although she was not an avid Twitter user, Davis came up with the hashtag #BlackInTheIvory, thinking it might be a good way for Black people to share their stories about racism in her sphere of influence. Folks tout the liberal ivory tower, she told me. They hide behind it.

She texted a friend, Joy Melody Woods, a doctoral student in the Moody College of Communication at the University of Texas at Austin, to see what she thought of the hashtag idea. I love it, Woods replied from her iPhone. Already tweeted it out. Davis followed suit, using the hashtag while retweeting a physician named Shaquita Bell: Black individuals in the United States have endured events in our everyday life without an audience or validation of our experiences.

The next morning, Davis and Woods found their notification in-boxes filled with hundreds of tweets from Black academics and graduate students, sharing their stories of exclusion and pain. By Sunday night, #BlackInTheIvory was one of the top twenty hashtags in the country. #BlackInTheIvory is being asked during your first week of college if youre sure you can handle it, many said, or being asked on campus if youre in the right place or lost. #BlackInTheIvory is having campus security constantly ask for your research-lab badge, residence-hall identification, and/or drivers license. Marc Edwards, now an assistant professor of biology at Amherst College, recalled that, in graduate school, at another institution, a dean suggested he wear a tie to class in response to incessant profiling. #BlackInTheIvory is being thrashed in student evaluations for discussing racial injustice, Danielle Clealand, a political scientist at the University of Texas at Austin, wrote. And my personal favorite: #BlackInTheIvory is being asked to serve on endless diversity committees and write endless diversity reports, without regard for ones labor or time, also known as the Black tax. To drive the point home, Woods and Davis posted Venmo bar codes on their Twitter feeds for anyone who might care to contribute.

The movement took off, with feature stories in Nature, The Chronicle of Higher Education, NBCNews.com, and the Boston Globe. Davis and Woods created a Web site, which sold branded merchandise and launched an effort to match Black graduate students in need with donors. Not the Diversity Hire, read the text on one coffee mug.

Youre finally seeing people opening up and sharing these experiences, Woods said. We had been feeling like we were alone.

When Woods and I spoke in June, she told me the story of her own experience as an incoming graduate student. In the fall of 2016, she was the only Black student on her track in a masters program in public health at the University of Iowa. The college had no Black faculty, and Woods said that professors made it clear that she didnt belong, that she wasnt smart enough. One professor told her directly that she didnt have the skills to be a graduate student.

I was feeling maybe I am dumb, she said. I thought I was going insane. I would just be on the floor crying.

Toward the end of her first semester, Woods tried reporting one faculty member to the universitys Office of Equal Opportunity and Diversity, but the complaint went nowhere. Its hard to prove microaggressions, she said. Thats why we think were going crazy.

In Woodss second semester of graduate school, a private psychologist tested her for learning disabilities. She discovered that she had three: a reading impairment, a visual-spatial processing disability, and a nonverbal learning disability. The psychologist told Woods that she didnt know how she had managed to finish high school. Yet her professors refused to provide learning accommodations, as is required by law. (In response, a spokesperson from the college said that we have made progress since 2016, but it is not enough. We are determined to do better.)

So she left. Walked right across the bridge, as she put it, transferring to the College of Education, where she found three Black professors, an Asian-American adviser, and far more Black students in her classes. I was never the only anymore, she said. The course readings also featured more diverse authors, and, because they explicitly addressed issues of inequality, it was easier to have open conversations about racism. In her new program, Woods completed a masters degree in Educational Policy and Leadership Studies with an emphasis on the sociology of education.

But, in many ways, Woods is an exception. Both of her parents have bachelors degrees in electrical engineering, and her two older sisters have graduate degrees in medicine and science. Many other Black students leave graduate programs in despair, but Woods felt that her family simply wouldnt accept her defeat.

She persisted, but her education came at a cost. These experiences are traumatic, Woods said. They can be isolating and emotionally battering. The problem of being the first and the only Black person in any institution is that being alone makes it much easier for white majorities to dismiss ones perceptions.

As a doctoral student at the University of California, Santa Cruz, I experienced the same isolation and resentment that Black women are now once again shouting about from their Twitter-feed rooftops. I know all too well what #BlackInTheIvory is about. I was already writing about my time in graduate school when I came across the hashtag. It took a moment for its meaning to sink in. For so long, I had recalled my experiences in isolation, pushing them to the corners of my memory and doing my best to make them small. #BlackInTheIvory reminded me that, like Woods, I wasnt alone.

In 1988, I was the first Black woman to enroll in my Ph.D. program in ten years. I was there, really, only because my undergraduate mentor, Elliott Butler-Evans, a Black professor in English at the University of California, Santa Barbara, had insisted on it. He had attended the program and received his own Ph.D. there, some years earlier. He told me about the dearth of Black women with tenure in the U.C. system. In his eyes, getting a doctorate was my civic duty. So I went to graduate school.

There were seven incoming students at the history-of-consciousness program at U.C. Santa Cruz that year: five white men and women, me, and a Chicano from Los Angeles named Raul. One afternoon, the conversation in our first-year seminar turned to race.

Our professors for the seminar, Donna Haraway and Jim Clifford, were two of the most formidable minds I had ever met. The conversation was stimulating, as I recall. Something about how racial meaning is socially constructed, perhaps, rather than strictly biological. I was only just beginning to wrap my head around post-structuralism and theory, and the concepts were still fresh and new. But it soon became apparent that a young woman in our cohort was becoming agitated. Ill call her Mary. She shifted in her seat as though biting her tongue.

Its just that Im Italian-American and... I get really tan in the summer, Mary said. She paused, searching the room. It seemed that no one had a clue what she was getting at. Raul and I exchanged confused looks, waiting for her to complete her thought.

I mean, I get even darker than her, she said, crooking her chin in my direction. And thats when she hit me with it. So... I dont understand, why does she get to be Black?

I wish I could say that anyone had a good response to what Mary had said. If they did, I dont recall. I remember only the silence.

I was isolated in a program in which not a single student or faculty member looked like me, or my mother, or my grandmother, or anyone in my family. All around me were hippie-like surfer students, white kids who found it perfectly acceptable to walk the woodsy paths barefoot on a warm day, or to wear their straight hair in clumped mats. For so many of them, college was an inevitable part of growing up. They treated the privilege with a certain casualness that I, as a first-generation student, did not share.

And, although I didnt think of it that way at the time, I crossed a bridge that year in search of bolstering, just like Joy Woods. I made my way across campus, over to Kresge College, where I found the writer Gloria Anzalda working on a doctorate in literature. Gloria called herself a Chicana-Mexicana-mestiza. She had edited a seminal book for Black and brown feminists, This Bridge Called My Back: Writings by Radical Women of Color, that was mandatory reading in womens-studies courses across the country. I also found Ekua Omosupe, an African-American single mom from Mississippi. We three became friends. I was no longer alone.

Im putting together another anthology, Gloria told me one day, and I was wondering if you have any essays or poems youd like to contribute? She did that thing which is so often missing from our lives as Black scholars and academics. Nurturing.

It doesnt have to be polished. Just send me what you have. My essay, which I called Light-Skinnedded Naps, appeared in Making Face, Making Soul/Haciendo Caras the next year. It was my first published piece of writing. I was twenty-three years old.

Not long afterward, the literature department brought the novelists Toni Cade Bambara and Buchi Emecheta to campus, as distinguished visiting professors, and my life changed again. I became their teaching assistant, crossing campus regularly to commune with my newfound Black community.

One day, after class, I walked with Toni back to her office. The day was bright and impossibly bluewhich made her next words seem incongruous. She pulled a small AM radio from her pocket. Always carry a short-wave radio, she told me. For when the revolution comes. I loved her commitment to revolutionary ideas, and to Black people, and to me.

I plopped myself down in a chair in her office, continuing our conversation. Mostly, I was hungry for her affirmation, which she gave freely. Years later, I found an old cassette tape of an interview she gave for my dissertation, on nationalist desire in Black television, film, and literature. Playing it back, I was mortified to discover that I had done most of the talking. Toni listened patiently, offering mm-hmms in all the right places.

With Buchi, a Nigerian novelist, one day in particular stands out in my memory. She stood before a class of white students, pausing to survey a Douglas fir outside the window.

For you, the trees and the forest are very beautiful, she said. Beau-ti-ful, she repeated, enunciating each syllable with her thick, British accent. But for me I see something more in the forests.

Uh-oh. I surveyed the room, sensing what was coming.

I see fear and danger. She pronounced this last word dan-jah, allowing it to linger in the coffee-scented air for a beat or two. You just dont know who might be behind those trees. The class considered her words in silence. She was right, and they knew it, although I doubt that a Black person had ever said this to them before in quite that way.

And, if something happens, well, then... Im just another Black woman gone. I wouldnt even get two sentences in the newspaper. Buchi paused, allowing students to sit with their discomfort awhile. One rustled papers. Another crossed and uncrossed her legs.

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How Black Lives Matter Came to the Academy - The New Yorker

Breonna Taylor: A beloved sister becomes a symbol of pain, an icon of hope – USA TODAY

Nearly ayear after Breonna Taylors death, manypeopleare remembering her as an iconic symbol of the BlackLives Matter movement: a youngfirst-responderinnocent of any crimewho lost her lifein a hail ofpolicebullets in her own home. Photos and illustrations of her have been on magazine covers, spotlightingher as a victim ofoverzealouspolicing, with accompanyingarticles demanding justice and change.

But when JuNiyah Palmer thinks about Breonna Taylor, she calls her sister. She remembers her sister as a confidante and friend.

She was lovely, she was caring, said Palmer.

In a December interviewwithUSATODAY, Palmer, 21,recalled the summers she and Taylor spentwith their grandmother in Grand Rapids, Michigan.One moment etched in her memory is the car ride back home to Kentuckyone year.Theydusually taken the ride with their mother, Tamika Palmer, but thistimethey were driving the route by themselves.

It started to pour down rain. Taylor, who was driving,couldntsee.The carinched along in the middle of the highway.It was just really funny, because she really stopped and started crying because she couldnt see, and called my mama, Palmer said.

Their mothertold them to pull over to the side of the highway and put the hazardlights on, but theydidntmove.They stayed in the middle of the highway for about 20 minutes, until the rainpassedandTaylorfelt fine to drive again.

To Palmer,Taylor was playful, yet vulnerable in otherwordsvery much like any otheryoung Black woman.

Tamika Palmer, left, embraced her daughter Juniyah Palmer during a vigil for her other daughter, Breonna Taylor, outside the Judicial Center in downtown Louisville, Ky. on Mar. 19, 2020. Taylor was killed during an officer-involved shooting last week. The family chose the vigil site because it is across the street from the Louisville Metro Police Department.1-Vigil01 Sam [Via MerlinFTP Drop](Photo: Sam Upshaw Jr., Courier Journal/ USA TODAY Network)

Astheanniversary of her deathapproaches,Palmer andsocial justiceactivists areworking to keep her legacy aliveby pushing for police reforms and public policies that would prevent more needless deaths like hers.

Breonnas life mattered,saidBrittany Packnett Cunningham, founder ofthe social impact firmLove & Power Works and host ofaMeteor/Pineapple Street Studiospodcast,Undistracted.We have to wake up every day and ask ourselves what we owe her.

Taylor, 26, was killed in her home at about 1 a.m. March 13, by Louisville Police who had a "no knock" search warrant for her apartment. Taylor and her boyfriend, Kenneth Walker III, were in the apartment that morning when they heard loud pounding at the door. According to Walker, the police did not announce themselves before breaking down the door. Fearing a home invasion, Walker fired one shot, hittingSgt. Jonathan Mattingly in the leg.

Police responded by firing 32 shots. Taylor was hit multiple times and died on the floor of her hallway whileMattingly, whowas wounded, was rushed to surgery.

In September, a grandjury charged former Detective Brett Hankison with wanton endangerment because some of the 10 shots firedwent into a neighboring apartment. But none of the three white officers involved were charged with Taylor's death.

This undated file photo provided by Taylor family attorney Sam Aguiar shows Breonna Taylor in Louisville, Ky. In news reported on Tuesday, Dec. 29, 2020, Louisville police have taken steps that could result in the firing of an officer who sought the no-knock search warrant that led detectives to the apartment where Taylor was fatally shot.(Photo: Taylor Family attorney Sam Aguiar via AP)

"Breonnas Law," legislation banningno-knock search warrants, was adopted in June by the city of Louisville. Similar no-knock bans existinFlorida, Oregon andVirginia.But such laws haven't been universally adopted, not even inKentucky.Soactivists worry thissame scenario could play out elsewhere.

You owe it toher tosee Breonna in every Black woman you encounter at work, schoolor delivering your groceries, andtreather like her life is worth living before she dies, Packnett Cunningham said.

Activists in Louisville and beyond arepushing for police reforms and accountability for police officers. They continue to demandcharges against the officers involved in Taylors death despitethe refusal of the Kentucky Prosecutors Advisory Council last December to appoint someone to pursue the case.

Imani Smith, a native of Kentucky and sophomore at Centre College, said she owes her activism to Taylor. After learning about her, Smith formed her own organization called the Youth Resistance Collective.

She is also collaborating with organizations like Change Today, Change Tomorrow;Play Cousins Collective and The Louisville Urban League, and pushing forward in social justice work by bringing awareness toTaylors story. The work involves changing policies, creating strategies that sustainthe Black dollarand teaching Black history.

Right now we are still in that process of still pushing, but also being conscious that we have to heal too because this was traumatic for a lot us, Smith said.

Protesters demonstrate on the steps of the Tennessee Capitol on Sept. 26, 2020, in Nashville in response to a Louisville grand jury decision about the fatal shooting of Breonna Taylor.(Photo: Mark Zaleski, The Tennessean/ USA TODAY Network)

During last yearsBreonnaConevent in Louisville,convenedto inspire activism in the wake of Taylors death, young Black women like Jaida Hampton,22, Youth & College President of the Kentucky NAACP State Conference, heldvoter education and registration sessions and legal roundtables.

Being a Black woman myself, living in Kentucky alone, (I know) that could potentially happen to me, and I have older sisters as well that are the same age as Breonna Taylor, Hampton said.

Black women are not safe at all in this country(if)you can innocently be sleeping in your own home and all it takes is for someone to make a life decision for you. That is just scary, Hampton said.

If Palmer could have told Taylor one thing on March 12last year,she would have told her to go to their moms housethat night, or to work some overtime. If this was adream,I would literally tell hertogo to pick up that shift at work that you planned on picking up, or go to moms house, and go out like you planned,Palmer said.

The days are longer than normal for Palmer, who shared the apartment with Taylor just as she had shared a room with her growing up.She wasused to coming home and seeing Taylor getting ready to leave for work. Taylor workedeveningsas an emergency room technician at the University of Louisville HealthJewish Hospital and Norton Hospital,and wanted to become a nurse.

Rosie Henderson tries to protect a Breonna Taylor memorial from rain Sept. 27, 2020, in downtown Louisville, Ky.(Photo: Max Gersh, Courier Journal/ USA TODAY Network)

Other times Palmer would come home and gointo Taylors room toplayfully bother her sister as she watched TV.Little memories like this,ormundane tasks like cleaning her room or washing her car, make Palmer miss Taylor the most.My outlook of the future has changed, any day could be really anybodys last day, Palmer said.

When Palmerseesimagesof her sisterpainted on muralsin brighthues or printed on the cover of magazines it makes her feel joyful.

It makes me feel like people are still thinking about her, were no longer lonely about the whole situation, Palmersaid.

Walker talked about protests in Breonna Taylor's name, and how his life has changed since her death. Louisville Courier Journal

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Breonna Taylor: A beloved sister becomes a symbol of pain, an icon of hope - USA TODAY

USC looks to preserve the Black Lives Matter Movement through firsthand experiences – WLTX.com

Researchers are working to preserve the history that is being made today.

COLUMBIA, S.C. The University of South Carolina is launching a new projectto showcase and preserve first-hand experience of the Black Lives Matter Movement.

Last summer, the deaths of George Floyd, Breonna Taylor and others prompted an outpour of voices for Black Lives Matter in the United States.

Now, researchers at USC are hoping to preserve these experiences for future generations through a grant from USC'sRacial Justice and Equity Fund.

Amie Freeman is a scholarly communication librarian at USC and is helping to form Voices of SC: Black Lives Matter.

As a librarian, we sort of recognize what is going to be historically important in the long term," Freeman said.

The project is asking for those who are willing to share their experiences with the project, whether that be photos, videos, art, poems, stories or whatever else may be significant to their experience.

These are experiences that deserve to be lifted, that deserve to be documented and deserve to be preserved just because future generations are going to look back at this moment and they are going to want an understanding," Freeman said, "They will want to hear first hand from all of the people who were involved in doing this work.

Black Lives Matter South Carolinas founder Lawrence Nathaniel thinks what USC is doing is a good way to preserve their history.

Preserving the history so our next generation can have the opportunity to understand the mistakes and to understand what we all learned to help our country and our state move forward, he said.

One of the things that's really important to us is having potential participants understand that we care about them and we respect their privacy and their right to participate or not participate as they see fit," Freeman said, "Because it is a very personal decision and we want people to feel comfortable with whatever it is that they decide.

Freeman says they hope to eventually have a virtual museum experience to permanently hold these records.

Students can also earn money through the project's Student Outreach Partner program where you help recruit people to tell their stories.

To read more about the program and submit an experience, visit their web page here.

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USC looks to preserve the Black Lives Matter Movement through firsthand experiences - WLTX.com

Bills filed to counter Black Lives Matter protests – The Herald Bulletin

INDIANAPOLIS After a summer of Black Lives Matter protests, Republicans at the Indiana Statehouse introduced a slew of bills aimed at relieving the strife and civil unrest of business owners and law enforcement.

We had businesses that were destroyed in downtown Indianapolis and those owners really were helpless, Sen. Michael Young, who chairs the Corrections and Criminal Law committee, said Tuesday.

The committee discussed and heard testimony for Senate Bills 187, 198 and 199 that seek to create a policy statement on historic monuments, enhance rioting penalties and expanded self-defense protections, respectively. Bills 198 and 199, both authored by Young, R-Indianapolis, were held back for further amendments but had testimony.

Senate Bill 187, by Sen. Eric Koch, R-Bedford, passed unanimously with no opposition.

Guy Relford, founder of the gun rights group 2A Project, spoke on SB 199, which expands the definition of reasonable force in relation to self-defense. Under the bill, business owners can defend their properties from threats of violence with reasonable force which includes pointing a loaded or unloaded firearm.

Under Indiana code its a crime to point a firearm at someone unless youre justified in using reasonable force, Relford, an attorney, said. The problem what (is) when one is defending their property, theyre not only talking about their home. Were talking about property other than their home (which) could be a business.

Relford said that current law would make protecting your business with a loaded firearm a felony or a misdemeanor if using an unloaded firearm.

Michael Moore, the assistant executive director of the Indiana Public Defender Council, worried the bill would encourage citizens to act as law enforcement officers.

Young said the above issue would be examined and possibly addressed by amendment next week.

Youngs other bill, SB 198, had over an hour of testimony and opposition from both public defenders and prosecutors. He said he crafted the bill to protect the rights of peaceful protesters but wanted to send a message to those who destroyed property.

But other committee members worried about how the lengthy bill would impact Hoosiers without foreknowledge of any crimes.

The unlawful assembly definition as we discussed here is kind of confusing and its very broad, Sen. Karen Tallian, D-Portage, said. You may have a group that comes to peacefully demonstrate something and all of the sudden somebody in that group spontaneously committed some(thing) that turned into a melee. Now all of the other people who come to this demonstration can be charged.

Taillian noted that, under this law, everyone at the D.C. riots on Jan. 6 would be held responsible for the five deaths that occurred, possibly even law enforcement officers who underestimated the crowd.

Moore said his organization had serious concerns about the bill, its impact on the right to assemble and its denial of bail to those charged with crimes.

The bill essentially ignores the root causes of why people protest; it goes to the aftereffects of when some people turn and riot its important to understand that riots dont happen first, protests do, Moore said.

Moore said that looting, vandalism, battery and criminal mischief already had penalties under criminal code. Requiring people to leave a rally turned violent or report the crimes was unprecedented and could be used to criminalize bystanders and observers.

We have concerns that this is a wide net that could encompass a lot of people and make them a criminal when in fact they were a bystander, Moore said.

Tallian wondered if the bill could be used to prosecute journalists reporting on riots and other legal observers.

David Powell, the executive director of the Indiana Prosecuting Attorneys Council, similarly opposed the bill and its limits on prosecutorial discretion by allowing the attorney general to step in and press charges if local prosecutors refused to do so.

We just dont see a need for this, Powell said. We can live with a lot of it, but there are things that need to be cleaned up.

Young said amendments to both of his bills would be considered in the upcoming weeks.

The bills authors, Young and Koch, both said the summers events inspired the bills, though a report found that 93% of Black Lives Matter protests were peaceful and just 7% qualified as riots.

The Armed Conflict Location and Event Data Project, which conducted the analysis, found that counterforces against protesters, such as armed military officers or militia groups, played a role in escalating the violence seen at protests.

The IndyStar wrote that Indianapolis businesses reported more than $2 million in damage and Marion County Prosecutor Ryan Mears charged 27 people out of the 100-plus arrested.

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Bills filed to counter Black Lives Matter protests - The Herald Bulletin

Nonprofit barred for supporting Black Lives Matter may be allowed back in Maine jail – Press Herald

ELLSWORTH A nonprofit that helps inmates recover from substance abuse could be allowed back in the Hancock County Jail starting Friday, seven months after the agency lost access over its support for Black Lives Matter.

County Commissioner Bill Clark, Healthy Acadia Executive Director Elsie Flemings and Sheriff Scott Kane met Monday morning.

Clark said Monday afternoon that as a result of Monday mornings meeting, a memorandum agreement is being drafted and should be finalized by Friday.

Sheriff Kane canceled the contract after Healthy Acadia issued a June 10, 2020, statement in support of the Black Lives Matter movement. Kane disagreed with allowing an organization in the jail that supports a movement that he says wants to harm law enforcement.

The Hancock County Commissioners met Saturday evening via Zoom, an online meeting platform.

Fleming reached out to me and weve set a date 9 oclock on Monday morning, that if we can get an agreement, she can start recovery coaching immediately, Clark said Saturday. Im confident we will have recovery coaching by the end of the day [Monday].

Commissioner Paul Paradis said he had talked to the sheriff earlier Saturday. He was a perfect gentleman, Paradis said.

Kane will be making a public statement at beginning of the commissioners meeting, on Tuesday [Feb. 2], said Paradis.Iview this as very positive and I want to thank the sheriff, Elsie Flemings and Chairman Clark for the work in re-establishing recovery coaching.

Recovery coaches, according to Flemings, provide an opportunity for inmates to develop an action plan for their release as well as work on their recovery.

The organization posted statements last summer supporting Black Lives Matter and the racial justice movement and criticizing racism and police brutality. Kane characterized the movement as seeking to harm police.

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Nonprofit barred for supporting Black Lives Matter may be allowed back in Maine jail - Press Herald

Black Lives Matter at School Week of Action 2021 – School Library Journal

It's Black Lives Matter at School Week of Action. Resources and a starter kits are available, along with the new contest-winning logo from a South Carolina high schooler.

The first week of February isBlack Lives Matter at School Week of Action. This year, BLM at School is not limited to February's Black History Month. Instead, the Week of Action comes in the midst of BLM at Schools Year of Purpose, during which every month of the academic year focuses on a specific principle. Februarys principle is Unapologetically Black. The website offers resources, including a starter kit, for the Week of Action.

The 2021 student creative challenge prompt is, What makes you feel free to dream, safe to thrive in schools and communities? Students are asked to share their response on social media with the hashtag #BLMAtSchoolChallenge.

[Read: Curricular Correction: Using Resources To Teach Black History and Culture]

South Carolina high school student Naima Whitted won the 2021 Black Lives Matter at School logo contest.

I wanted to show the importance of #BlackLivesMatter by showing the past and present coming together, said Naima, a high school freshman in Columbia, SC. The girl in the image has modern braids and wears a COVID mask, but the Black Power fist has a history from the 1960s that still has meaning today.

The logo appears on merchandise and social media posts.

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Black Lives Matter at School Week of Action 2021 - School Library Journal

How the Radical Graphic Design of the Black Panthers Influences the Movement for Black Lives – HarpersBAZAAR.com

Vanessa Newman can remember exactly where they were when they first saw Emory Douglass work. They remember the sound of '60s jazz vinyls playing before heading to the grocery store with their dadan embodiment of their love for Black people as a Black queer kid navigating the world. Douglas's work was integral to the music and, really, every day of their childhood.

A revolutionary artist and the former minister of culture for the Black Panther Party, Emory Douglas was a formerly incarcerated youth who fell in love with graphic design in trade school and after attending San Francisco City College connected with the likes of party cofounder Bobby Seale. Together, they created The Black Panther in 1967, the newspaper reaching its peak with a 200,000+ weekly circulation. Also a living vessel of Black radical history and visioning, Douglas used printmaking and graphic design to best articulate the Black liberatory politics of the Black Panther Party via comics, illustrations, and visual propaganda.

Its fitting that Newman was so drawn to Douglas's work. This current iteration of young Black queer people building a new visual statement through the Movement for Black Lives looks to the Black Panther Party as a starting point. Designers like Newman and Fresco Steez, the former minister of culture at BYP100, uses the poetics of adornment, a clarity of political values, and a hunger for a new world that many deem impossible. These designers are melding together past, future, and current realities to make revolution irresistible. Douglas and his work have provided the blueprint for that liberatory design.

Joe AmonGetty Images

Anyone dedicated to a future that requires Black liberation must use all the tools available to make the fight visually, linguistically, and spiritually appealing to those invested in their own freedom. As Douglas stated in 1967 of his mission in helping to create the Panthers' newspaper, also with Panther leader Eldridge Cleaver, "We were creating a culture, a culture of resistance, a culture of defiance and self-determination."

Like Newman, Steez is a designer dedicated to creating the visual language of this social moment. Born in Chicago, the community organizer is deeply involved with BYP100, a chapter-based organization founded in 2013 in response to George Zimmermans acquittal. Dedicated to advancing the Black communitys economic, social, political, and educational freedoms, BYP100 sees the future through a Black queer feminist lens. Throughout her time there, she designed all the merchandise for the organization, from hockey jerseys donning Lucille Clifton quotes to "Unapologetically Black" T-shirts inspired by Kanye Wests GOOD Friday music drops.

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Steez is also the former lead digital strategist at the Movement for Black Lives (or M4BL), where she recently designed bomber jackets, sweatsuits, and full regalia for fellows that speak to the continued defunding of the police campaign work. Further, she is currently working with Levis for its Black History Month capsule due out this month.

Steez began her design work at BYP100 as a reflection of two vital aspects of her life: community organizing and hip-hop. She thinks critically about what hip-hop culture means for organizing internally and externally. As a teenager doing organizing work, I was required to study the five elements of hip-hop (tagging, beatboxing, break dancing, emceeing, deejaying) and streetwear culture. And while we know that streetwear culture is Black culture, it has been commodified by all different identities of folks in order to build profit. This exploitation is compounded by luxury brands at the expense of Black and third-world people.

Steezs mother, Sheila Rollins, was a teacher by trade and matriarch of design by craft in Chicago. Steez follows a legacy of Black feminist ingenuity that keeps her rooted in the liberatory needs of Black people. My early understanding of how Black folks use visuals, fashion, aesthetics as a culture to resist poverty; to say, 'Despite the conditions we live in in this country, were gonna adorn ourselves in ways that glorify our experiences,'" Steez says. "We know that our clothes can be a vision for what our lives can be around beauty and around the full and expansive life that we deserve.

She continues, The thing that has inspired me in all the work that I do are the political histories and movements. What were the visuals? What was the culture behind them that was intentional? What gave them a visual identity to the community that they were working within?

The type of intentionality and care that Steez puts into her work is a deep nod to Douglas's work in developing a visual culture for the Black Panthers. As the party grew in notoriety and political acclaim in the late '60s, so did the surveillance of its leadership, namely the creation of COINTELPRO, a counterintelligence program focused on monitoring and dismantling the radical organizing work of the Black Panther Party by the federal government. These acts of intentional upheaval through COINTELPRO included everything from disrupting newspaper distribution to destroying the childrens breakfast program. These tactics of destruction are still ever present in the FBI's more recent creation of the Black Identity Extremists designation and the policing of Black activists across the country amid protests against police violence. The legacy of the suppression of Black liberatory struggle continues to this day.

We know that our clothes can be a vision for what our lives can be around beauty and around the full and expansive life that we deserve.

There is a cold eye of intimidation being used now to quell the fight for Black liberationa similar intimidation that killed and nearly wiped out the Black Panther Partybecause of the radicalization power that can happen with visual art. At the height of the uprisings this summer, there was a need for personal protective equipment, or PPE, which many didnt know how to fill. Steez and the digital team at M4BL knew that they could show up and keep people safe with masks, while also getting their bold statement across. These are new conditions to be organizing under, so we really thought about what piece actually supports their organizing work and clearly articulates their values, and the most relevant canvas in this moment was the face mask.

M4BL began sending out needed PPE to activists on the ground in seven major cities during the peak of the George Floyd uprisings, in early June. Masks with the phrases, Stop Killing Black People and Defund Police, were sent out nationwide. However, after shipping the masks, Steez was told that they allegedly had been seized by the federal government and were delayed until further notice. It wasnt until Steez and M4BL took to social media to spread awareness of the supposed PPE steal that the masks were returned to them.

If you have the grounds to seize these masks, then what grounds do you have to seize me? Right, in all seriousness.

The bold black-and-yellow masks were everywhere during the protests. Representative Ilhan Omar was seen wearing one, and former president Barack Obama even reposted an image of the masks on social media. But Steez is remaining focused on her core values of creating political timepieces that have clear principles.

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Like Steez, Newman is dedicated to tracing the connection between the history and principles of design to organized movements. As head of product at Somewhere Good, a digital platform from the same team behind Ethels Club, they are dedicated to creating a social media app that prioritizes a new way of being online.

Newman credits their precision in graphic design and the ability to gain access to resources to the strength of community organizing. I began to see that space making and community organizing are all design systems. Most of the Internet is not meant to build community; it was built to monetize people, they say. "The past two years of building brands, dreaming of flyers, and getting into the nerdiest details of typography always come back to finding what's been lost. I feel like Im always trying to reclaim a history that already exists.

The biggest lesson in a year of isolation has been that the vision for liberation is a collective work. In the midst of the months-long protests over the summer, Newman along with other Black designers began Design to Divest, "a Black-led collective of designers, artists, technologists, and strategists designing equitable futures by divesting from inequitable institutions," as stated on its website.

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However, Newman has no illusions about the visceral labor of dreaming. When youre Black and queer, you have to always be imagining. Explaining further, Newman says, I protect my brain at all costs. How do you do that in this world where you are supposed to stay disconnected from yourself, from your body, and from this world. All of these things are designed to distract us from our imagination.

Radical graphic design, whether it be through merchandise or visual aesthetics, has always been about writing a love letter to marginalized peopleto say without words or dialogue who you are, what you stand for, and how you are showing up for the next fight. It is a call to action after a year of grief and surface-level platitudes. Because of this struggle, Black queer designers like Steez and Newman are dreaming of what our movements must look like for a better world that many refuse to see.

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Beethoven Meets Black Lives Matter in Heartbeat Opera’s Breathing Free – San Francisco Classical Voice

In retrospect, the zany-keen ideas behind productions spawned by indie opera company Heartbeat Opera appear to be no-brainers. Celebrate the 250th birthday of a classical music composer who lost his ability to hear (yes, Beethoven) with the sound of revoked-by-incarceration and often-silenced voices of singers and volunteers from six prison choirs? Simple concept!

But the concept goes deeper than that. Engage professional vocalists and dancers to join the choirs and an exceptional eight-member band (with instrumentalists from the prisons featured in given selections) to create nine interconnected music videos? Yeah, sure thing! Add a contemporary slant by curating the cast and crew with an ear to young talent and eyes aiming to rectify historical imbalances when it comes to presenting people of color in classical music? For repertory, choose excerpts from Beethovens Fidelio, Negro spirituals, and musical works or words by Harry T. Burleigh,Florence Price, Langston Hughes,and Anthony Davis andThulani Davis?

Certainly, we could have thought of all of that ... except we didnt, and Heartbeat Opera not only thought of it all, they made the visual album project titled Breathing Free happen during a pandemic that had the artists rehearsing remotely on Zoom. The cast recorded individual audio tracks and videos that were filmed in separate locations. A music team compiled the recordings and a team of cinematographers led by filmmaker Anaiis Cisco collaborated on the videos that complete and connect the nine episodes forming the 45-minute work.

Presented with support from Santa Monicas The Broad Stage in a series of West Coast virtual premieres during Black History Month, Breathing Free is directed by Heartbeat Opera co-founder Ethan Heard. The song cycles Black voices arrive unfiltered and emerge without pretense from the rubble of events in 2020. Speaking raw truth to power, the lyrics and texts echo most unforgettably with the pain of George Floyds murder or arrive textured with the reverberations of a contentious political environment. In other sections, powerful unity demonstrates a people equipped to counter the forces of systemic bias perhaps these voices strengthened by the Black Lives Matter movement and how it spread around the world yet the music is rarely without grief-stricken tones lamenting twin pandemics COVID-19 and racial injustice that continue to disproportionately devastate the lives of black, brown and indigenous bodies. From the guest artists, the singers inside these six prisons and the voices of protest and resilience heard in traditional spirituals and newer compositions, the song cycles themes include strength, pain, dignity, honor, protest, betrayal, grace, and most hopefully, future dreams of justice and equity.

The program is presented Feb. 10 and 13 by The Broad Stage, and Feb. 2027 by the Mondavi Center. Follow the venue links for more details.

Each screening of Breathing Free is followed by a live panel discussion with the artists and advocates speaking on themes introduced by the film. Prison choirs participating in the project include Oakdale Community Choir, KUJI Mens Chorus, UBUNTU Mens Chorus, HOPE Thru Harmony Womens Choir, East Hill Singers and Voices of Hope.

Repertory presented in Breathing Free includes:

Balm in Gilead traditional,arr. Sean Mayes

Lovely Dark and Lonely music by Harry T. Burleigh, words by Langston Hughes

Malcolms Aria from X, The Life and Times of Malcolm X music by Anthony Davis,libretto by Thulani Davis, story by Christopher Davis,arr. Sean Mayes

Sometimes I Feel Like a Motherless Child traditional

Songs to the Dark Virgin music by Florence Price, words by Langston Hughes

Four excerpts fromFidelio music by Ludwig van Beethoven, libretto by Joseph Sonnleithner and Georg Friedrich Sonnleithner,arr. Daniel Schlosberg

Abscheulicher! (Abominable one! Leonores aria)

O welche Lust (Oh what a joy prisoners chorus)

Gott! Welch Dunkel hier! (God! what darkness here Florestans aria)

Euch werde Lohn (You shall be rewarded Act II trio)

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Beethoven Meets Black Lives Matter in Heartbeat Opera's Breathing Free - San Francisco Classical Voice

Evenings with Genetics: Race and Genetics | BCM – Baylor College of Medicine News

Do racial categories obscure our genetic similarities and differences? How do we quantify ancestry and is it important in precision medicine? This month, Baylor College of Medicine is hosting two Evenings with Genetics webinars to address these questions and other issues involving race and genetics.

The webinars will take place on Tuesday, Feb. 9, and Tuesday, Feb. 16, at 7 p.m. CST. Both sessions will address the role of race in genetic research and clinical care, as well as racial justice and bioethics in precision medicine.

This series focused on race and Black history is exciting and timely, said Dr. Debra Murray, assistant professor of molecular and human genetics at Baylor and co-organizer of the event. The invited speakers will bring to light several areas where genetics has been influenced by race. In order to pursue social justice, we must ensure science without bias. People with non-European ancestry should not be prevented from enjoying the promise of precision medicine.

The 15th anniversary of this series is the perfect opportunity to offer our community these discussions on the perception of race as we strive to ensure precision medicine is available to all, said Susan Fernbach, assistant professor of molecular and human genetics at Baylor and co-organizer of the event.

Panelists on Feb. 9 include Dr. Charmaine Royal, professor of African & African American studies, biology, global health and family medicine and community health at Duke University, Dr. Clayton Yates, professor in the Department of Biology and Center for Cancer Research at Tuskegee University, and Shawneequa Callier, associate professor in the Department of Clinical Research and Leadership at the George Washington University School of Medicine and Health Sciences.

Panelists on Feb. 16 include Dr. Rick Kittles, professor and director of the Division of Health Equities in the Department of Population Sciences at City of Hope, Dr. Charmita Hughes-Halbert, professor in the Department of Psychiatry and Behavioral Sciences at Medical University of South Carolina, and patient advocate J.H. Jones.

The program is free and open to the public, but registration is required. A Zoom link will be sent to all registered participants. For more information, call 713-798-8407 or visit the event registration pages for Feb. 9 and Feb. 16. Videos of both sessions will be available online here at a later date.

This event is sponsored by the Department of Molecular and Human Genetics, the Office of Diversity, Equity and Inclusion, the Human Genome Sequencing Center and Baylor Genetics.

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Evenings with Genetics: Race and Genetics | BCM - Baylor College of Medicine News

Genomic Testing Cooperative Establishes a Program to Address Cancer Disparity by Offering Molecular Profiling to Minority Patients without Adequate…

IRVINE, Calif.--(BUSINESS WIRE)--Genomic Testing Cooperative, LCA (GTC) announced today that they are establishing a program offering comprehensive molecular profiling (DNA+RNA) testing to patients with cancer who are affected by cancer disparity and unable to pay due to lack of insurance or lack of coverage of this type of testing. Ethnic and racial minorities, impoverished people, sexual and gender minorities (LGBTQ) are typically affected more negatively with cancer. One of the reasons for this disparity is poor access to precision medicine and exclusion from clinical trials or studies evaluating the potential differences in the biology of their cancer.

GTC molecular profiling will provide the treating physicians and patients with proper diagnosis and classification of the tumor, help in determining prognosis, selecting therapy and in developing a strategy for treatment that is specific for the patient. The molecular profiling report provides information regarding potential clinical trials that will help the patients evaluate their options to participate and be treated in these clinical trials. Participation in this program will increase access of underserved patients and reduce disparity within community-based cancer care. In addition, the data generated from this program will be de-identified and made available to appropriate academic and scientific groups for the purpose of developing more personalized cancer treatment for minority groups of patients.

GTC is committed to donating 5% of its annual testing volume to this program. GTC is also establishing a donation fund allowing others to support this program and to increase the number of patients benefiting from this program. Individual donors and organizations can contribute to this program with 100% of the raised funds being used to pay for the actual cost of testing.

Patients must be nominated for this program by their physicians. Patients with solid tumors or hematologic neoplasms are eligible for testing. Hematologists/Oncologists can download a simple nomination form from the GTC website, fill in the required information and fax or e-mail to GTC. Patients can mention this program to their hematologists/oncologists and request nomination for this program.

Dr. Maher Albitar, GTC Chief Executive Officer and Chief Medical Officer, stated GTC is committed to making cancer molecular profiling available to all patients with cancer. We all know that patients seen in academic centers are different from real-world patients. Minority patients are not adequately represented in the process for developing innovative medicine nor in the implementation of state-of-the-art medicine. As a diagnostic company, we are doing our part by defining the precise molecular abnormalities that can be targeted but having access to the expensive targeted therapy is a different struggle. We are hoping that pharmaceutical companies will join our effort and do their part in providing the appropriate drugs to these patients and will develop a mechanism to recruit them in their clinical trials.

A recent study reported that one-third of disparities in survival between white and black patients with stage IV colorectal cancer is a product of treatment gaps (HemOnctoday, January 21/2021).

For downloading the patient nomination form, donations or more information, please visit our website genomictestingcooperative.com

About Genomic Testing Cooperative, LCA

Genomic Testing Cooperative (GTC) is a privately-owned molecular testing company located in Irvine, CA. The company operates based on a cooperative (co-op) business model. Members of the co-op hold type A shares with voting rights. The company offers its patron members a full suite of comprehensive genomic profiling based mainly on next generation sequencing. Molecular alterations are identified based on rigorous testing with the aid of specially developed algorithms to increase accuracy and efficiency. The clinical relevance of the detected alterations is pulled from numerous databases using internally developed software. Relevance of findings to diagnosis, prognosis, selecting therapy, and predicting outcome are reported to members. The co-op model allows GTC to make the testing and information platform available to members at a lower cost because of a lower overhead. For more information, please visit https://genomictestingcooperative.com/.

Forward Looking Statements

All of the statements, expectations and assumptions contained in this press release are forward-looking statements. Such forward-looking statements are based on the GTC managements current expectations and includes statements regarding the value of comprehensive genomic profiling, RNA profiling, DNA profiling, algorithms, therapy, the ability of testing to provide clinically useful information. All information in this press release is as of the date of the release, and GTC undertakes no duty to update this information unless required by law.

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Genomic Testing Cooperative Establishes a Program to Address Cancer Disparity by Offering Molecular Profiling to Minority Patients without Adequate...

Unlock the Long-Term Genomics Runway with ‘ARKG’ – ETF Trends

Ground zero for disruptive growth in the healthcare sector is genomics through the ARK Genomic Revolution Multi-Sector Fund (CBOE: ARKG).

ARKG holds equity securities of companies across multiple sectors, including health care, information technology, materials, energy, and consumer discretionary, that are relevant to the funds genomics theme. The active management team behind the ARKG strategy combines a top-down and bottom-up research methodology to identify innovative companies and convergence across markets.

The second generation of cell and gene therapy is one of multiple frontiers ARKG provides exposure to. Its also lacking in many old-school biotechnology ETFs.

New cell and gene therapy innovations could increase the total addressable market for oncology therapeutics by more than 20-fold, according to ARK Research.

The actively managed ARKG offers investors a thematic multi-capitalization exposure to innovative elements that cover advancements in gene therapy bio-informatics, bio-inspired computing, molecular medicine, and pharmaceutical innovations.

ARKG includes companies that merge healthcare with technology and capitalize on the revolution in genomic sequencing. These companies try to better understand how biological information is collected, processed, and applied by reducing guesswork and enhancing precision.

Interestingly, ARKG marries one disruptive technology with others.

The US Food and Drug Administration (FDA) approved Gleevec, an oral chemotherapy, after ten years of trials, seven years of which were in solid tumors. This timeline suggests that the FDA could approve the first CAR-T therapy for solid tumors in 2025, notes ARK. Because of artificial intelligence (AI), gene-editing, and next generation sequencing (NGS), failure rates and time-to-market should fall, accelerating approval rates.

The evolution of gene therapies from ex vivo to in vivo is another scenario worth monitoring in the coming years.

Unlike ex vivo, in vivo therapies cannot check edited cells before transduction. That said, in vivo gene therapy is more cost effective and easier to manufacture and scale. It also enables more access to the liver, eye, central nervous system (CNS), and muscles, concludes ARK.

For more on disruptive technologies, visit our Disruptive Technology Channel.

The opinions and forecasts expressed herein are solely those of Tom Lydon, and may not actually come to pass. Information on this site should not be used or construed as an offer to sell, a solicitation of an offer to buy, or a recommendation for any product.

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Unlock the Long-Term Genomics Runway with 'ARKG' - ETF Trends

Breast Cancer Gene Mutations Found in 30% of All Women – Medscape

CORRECTION February 4, 2020 // Editor's note: The original headline of this article incorrectly stated that breast cancer gene mutations were found in 30% of all women in a study. The mutations were found in 30% of women with breast cancer who were not at high risk of developing the disease.

New findings of breast cancer gene mutations in women who have no family history of the disease offer a new way of estimating risk and may change the way in which these women are advised on risk management.

The findings come from two large studies, both published on January 20 in The New England Journal of Medicine.

The two articles are "extraordinary" for broadening and validating the genomic panel to help screen women at risk for breast cancer in the future, commented Eric Topol, MD, professor of molecular medicine, Scripps Research, La Jolla, California, and Medscape editor-in-chief.

"Traditionally, genetic testing of inherited breast cancer genes has focused on women at high risk who have a strong family history of breast cancer or those who were diagnosed at an early age, such as under 45 years," commented the lead investigator of one of studies, Fergus Couch, PhD, pathologist at the Mayo Clinic, Rochester, Minnesota.

"[Although] the risk of developing breast cancer is generally lower for women without a family history of the disease...when we looked at all women, we found that 30% of breast cancer mutations occurred in women who are not high-risk," he said.

In both studies, mutations or variants in eight genes BRCA1, BRCA2, PALB2, BARD1, RAD51C, RAD51D, ATM, and CHEK2 were found to be significantly associated with breast cancer risk.

However, the distribution of mutations among women with breast cancer differed from the distribution among unaffected women, notes Steven Narod, MD, from the Women's College Research Institute, Toronto, Ontario, Canada, in an accompanying editorial.

"What this means to clinicians, now that we are expanding the use of gene-panel testing to include unaffected women with a moderate risk of breast cancer in the family history, is that our time will increasingly be spent counseling women with CHEK2 and ATM mutations," he writes. Currently these two are "clumped in with 'other genes'.... [M]ost of the pretest discussion is currently focused on the implications of finding a BRCA1 or BRCA2 mutation."

The new findings may lead to new risk management strategies, he suggests. "Most breast cancers that occur in women with a mutation in ATM or CHEK2 are estrogen receptor positive, so these women may be candidates for anti-estrogen therapies such as tamoxifen, raloxifene, or aromatase inhibitors," he writes.

Narod observes that for now, the management of most women with either mutation will consist of screening alone, starting with MRI at age 40 years.

The medical community is not ready yet to expand genetic screening to the general population, cautions Walton Taylor, MD, past president of the American Society of Breast Surgeons (ASBrS).

The ASBrS currently recommends that all patients with breast cancer as well as those at high risk for breast cancer be offered genetic testing. "All women at risk should be tested, and all patients with pathogenic variants need to be managed appropriately it saves lives," Taylor emphasized.

However, "unaffected people with no family history do not need genetic testing at this time," he told Medscape Medical News.

As to what physicians might do to better manage patients with mutations that predispose to breast cancer, Taylor said, "It's surprisingly easy."

Every genetic testing company provides genetic counselors to guide patients through next steps, Taylor pointed out, and most cancer patients have nurse navigators who make sure patients get tested and followed appropriately.

Members of the ASBrS follow the National Comprehensive Cancer Network guidelines when they identify carriers of a pathogenic variant. Taylor says these are very useful guidelines for virtually all mutations identified thus far.

"This research is not necessarily new, but it is confirmatory for what we are doing, and that helps us make sure we are going down the right pathway," Taylor said. "It confirms that what we think is right is right and that matters," he reaffirmed.

The study led by Mayo's Couch was carried out by the Cancer Risk Estimates Related to Susceptibility (CARRIERS) consortium. It involved analyzing data from 17 epidemiology studies that focused on women in the general population who develop breast cancer. For the studies, which were conducted in the United States, pathogenic variants in 28 cancer-predisposition genes were sequenced from 32,247 women with breast cancer (case patients) and 32,544 unaffected women (control persons).

In the overall CARRIERS analysis, the prevalence of pathogenic variants in 12 clinically actionable genes was 5.03% among case patients and 1.63% among control persons. The prevalence was similar in non-Hispanic White women, non-Hispanic Black women, and Hispanic case patients, as well as control persons, they add. The prevalence of pathogenic variants among Asian American case patients was lower, at only 1.64%, they note.

Among patients who had breast cancer, the most common pathogenic variants included BRCA2, which occurred in 1.29% of case patients, followed by CHEK2, at a prevalence of 1.08%, and BRCA1, at a prevalence of 0.85%.

Mutations in BRCA1 increased the risk for breast cancer more than 7.5-fold; mutations in BRCA2 increased that risk more than fivefold, the investigators state.

Mutations in PALB2 increased the risk of breast cancer approximately fourfold, they add.

Prevalence rates for both BRCA1 and BRCA2 among breast cancer patients declined rapidly after the age of 40. The decline in other variants, including ATM, CHEK2, and PALB2, was limited with increasing age.

Indeed, mutations in all five of these genes were associated with a lifetime absolute risk for breast cancer greater than 20% by the age of 85 among non-Hispanic Whites.

Pathogenic variants in BRCA1 or BRCA2 yielded a lifetime risk for breast cancer of approximately 50%. Mutations in PALB2 yielded a lifetime breast cancer risk of approximately 32%.

The risk of having a mutation in specific genes varied depending on the type of breast cancer. For example, mutations in BARD1, RAD51C, and RAD51d increased the risk for estrogen receptor (ER)negative breast cancer as well as triple-negative breast cancer, the authors note, whereas mutations in ATM, CDH1, and CHEK2 increased the risk for ER-positive breast cancer.

"These refined estimates of the prevalences of pathogenic variants among women with breast cancer in the overall population, as opposed to selected high-risk patients, may inform ongoing discussions regarding testing in patients with breast cancer," the BCAC authors observe.

"The risks of breast cancer associated with pathogenic variants in the genes evaluated in the population-based CARRIERS analysis also provide important information for risk assessment and counselling of women with breast cancer who do not meet high-risk selection criteria," they suggest.

The second study was conducted by the Breast Cancer Association Consortium (BCAC) under lead author Leila Dorling, PhD, University of Cambridge, United Kingdom. This group sequenced 34 susceptibility genes from 60,466 women with breast cancer and 53,461 unaffected control persons.

"Protein-truncating variants in 5 genes (ATM, BRCA1, BRCA2, CHEK2 and PALB2) were associated with a significant risk of breast cancer overall (P < .0001)," the BCAC members report. "For these genes, odds ratios ranged from 2.10 to 10.57," they add.

The association between overall breast cancer risk and mutations in seven other genes was more modest, conferring approximately twice the risk for breast cancer overall, although that risk was threefold higher for the TP53 mutation.

For the 12 genes the consortium singled out as being associated with either a significant or a more modest risk for breast cancer, the effect size did not vary significantly between European and Asian women, the authors note. Again, the risk forER-positive breast cancer was over two times greater for those who had either the ATM or the CHEK2 mutation. Having mutations in BARD1, BRCA1, BRCA1, PALB2, RAD51C, and RAD51D conferred a higher risk for ER-negative disease than for ER-positive disease.

There was also an association between rare missense variants in six genes CHEK2, ATM, TP53, BRCA1, CDH1, and RECQL and overall breast cancer risk, with the clearest evidence being for CHEK2.

"The absolute risk estimates place protein-truncating variants in BRCA1, BRCA2, and PALB2 in the high-risk category and place protein-truncating variants in ATM, BARD1, CHEK2, RAD51CC, and RAD51D in the moderate-risk category," Dorling and colleagues reaffirm.

"These results may guide screening as well as prevention with risk-reducing surgery or medication, in accordance with national guidelines," the authors suggest.

The CARRIERS study was supported by the National Institutes of Health. The study by Dorling and colleagues was supported by the European Union Horizon 2020 research and innovation programs, among others. Narod has disclosed no relevant financial relationships.

New Eng J Med. Published online January 20, 2021. Couch et al, Abstract; BCAC study, Full text; Editorial

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Breast Cancer Gene Mutations Found in 30% of All Women - Medscape

Beyond DNA: The rest of the story – Science Magazine

ILLUSTRATION: MICHELLE KONDRICH

The availability of a fully sequenced human genome and genome-wide analyses of genetic variation have made DNA-based ancestry tests possible. These consumer DNA tests are now widely marketed as a way to discover or confirm family history. But what do they really tell us about our past, and what do they leave out? We asked young scientists to tell us about their family traditions, stories, and culture, and how they understood their DNA test results in the context of their lived experiences. Their stories are below. To read more reflections by young scientists, find past NextGen Voices pieces at https://science.sciencemag.org/collection/nextgen-voices. Follow NextGen Voices on Twitter with hashtag #NextGenSci. Jennifer Sills

My family comes from Jamaica and the Virgin Islands. There is no meal I would rather have than my mom's home-cooked traditional Jamaican food. Now living in Florida, my mom grows many fruits and vegetables native to Jamaica in a garden that occupies her entire yard. When I visit, we spend most of our time together outside picking fresh mangoes, ackee (a tropical fruit grown in Jamaica), or whatever else happens to be in season. On Christmas, she makes oxtail (a kind of beef stew, my personal favorite), fried dumplings, and ackee with saltfish (its traditional complement of salted cod). These foods are well-spicedalthough not always spicyand flavorful.

Where my family originated is mostly hearsay, and the full history beyond a few generations is hard to trace. My DNA test results confirmed that we have some background in Europe and likely moved to the Caribbean through the slave trade. The details echoed a story on my mom's side of the family that one of our ancestors was the child of an Irish slave master and a woman he enslaved.

I have mixed feelings about the business model of consumer DNA test companies, which make their profit based on the use of others' genetic informationin my mind, the most personal information one can share. However, my mom really wanted me or my dad to do the test to see how that side of our ancestry looked. I chose a company that gives users more control over who can access the results. Of course, these tests are not as accurate for those of us from non-European backgrounds, but the results were roughly what I expected, and it is humbling to think about where our family began compared with where it is now.

Gregg Duncan Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA. E-mail: gaduncan{at}umd.edu

My family is Han, the largest nationality of China. Like most families in China, we celebrate the Spring Festival (Chinese New Year) by gathering together to make and eat jiaozi (dumplings filled with vegetables and meat), which are shaped like ancient Chinese gold ingots to symbolize wealth. We hang festival couplets (two lines of poetry with the same number of words) that are painted along with intricate designs on red paper, and we put red lanterns and red candles on display throughout the house; the decorations symbolize happiness and protect us from the mythical monster named Nian, who is said to be afraid of the color red. While we wait for the New Year to arrive, we listen to Hebei Bangzi, the local opera, which sounds similar to the Beijing opera but is more difficult for people outside Hebei province to understand because the singers use pronunciations unique to the region. In my hometown (Shijiazhuang, Hebei), people of the same surname gather together to extend best wishes to their elders before the first sunrise of the new year.

Such traditions are a reminder that my surname (Ji) is not common in China. I hoped that finding out more about my family's origins would help to explain my unusual name. My DNA test results told me that 46.34% of my genome came from North China (Han), 20.13% from South China (Han), and 12.21% from Northeast Asia (Japan). I was disappointed that the results contained no detailed information that I found useful. I do not know how many Chinese people have a genetic pattern similar to mine, andunlike scientific researchthe company did not give me the raw data of my genome. Without more information about how the company analyzed my genomic data, I don't know what conclusions I can draw or even whether I should believe the test results.

Yongsheng Ji Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui, 230026, China. Email: jiys2020{at}ustc.edu.cn

Fifteen years ago, I probably would have said that my family didn't have a French cultural identity, despite being raised in France. Today, after having been expatriated 10 years in New Zealand, I can confirm that we have a strong French cultural identity, especially when it comes to food. Yet, after we returned to France 3 years ago, our attachment to our home country and its culture and traditions did not feel quite the same. I believe that we unintentionally took bits of New Zealand back to France with us.

Our ever-evolving celebration of Mardi Gras encapsulates our cultural journey. Before our move, we had always celebrated the French holiday in its traditional (if less religious) form. Around the end of February, we would make and eat loads of French crpes, and kids would dress up in festive costumes and attend the carnival. After our move, we discovered that New Zealanders do not observe Mardi Gras, so we adopted a different yet similar tradition, which was brought to the country from overseas and stuck: Halloween. Every year on the 31st of October, my eldest boy dressed up in a scary costume. But because good food is so deeply rooted in our culture, Halloween candy didn't feel sufficient. To supplement the prepackaged treats, we created our own tradition of the Halloween scary lunch. Each year, I would prepare a lunch box filled with funny and scary little monsters, skeletons, and ghosts made of pancakes, carved fruits, and (for the mummies) baked sausages in pastry strings.

Now back in France, we have resumed our celebration of Mardi Gras in February. The kids dress up for school and for carnivals, just like Halloween, but with an emphasis on festive instead of scary, and we make crpes, as we've done in the past. We've also kept our own multicultural family traditions. To adapt our New Zealand Halloween lunches, we now have a Halloween-themed French dinner in October. We've also updated the tradition of hiding a fve (trinket) in our galette des rois (king cake) by using a koru necklace (a traditional kiwi artifact) instead.

Our unique and changing traditions showed me that we could be open to incorporating new values and ideas when we learned the results of our DNA tests. My husband and I are both researchers in ecology and environmental genetics, manipulating DNA data daily and studying insect population genetics. It seemed only natural that we would want to see our own DNA test results. We originally thought that the genetic admixture might be quite high within our family home given that we were born 12,000 km apartI grew up in northern France, and he was raised on the French island of La Runion in the Indian Ocean. We were quite surprised by the results. For instance, I learned that I had ancestors from Italy and Scandinavia but very little French or Western European lineage, whereas my husband, despite being born in the Southern Hemisphere, has more Western European lineage than I do. (His results could perhaps be explained by the fact that half of the first settlers in La Runion were from Brittany.) Although my husband has ancestors in many parts of the world where I do not (such as India, Africa, and Indonesia), we share an unexpectedly high rate of ancestry from the Iberian Peninsula (Spain and Portugal). The results have not changed our lives, but it is interesting to know that, genetically, we are more an Iberian family than a French one! We now want to travel to and discover more about the culture of these southwestern parts of Europe and pass on this heritage to our children. As ecologists, we are curious about the natural and geological histories of the Iberian region, but we would make food an important part of the trip as well. They may not have French crpes in Portugal, but I have heard that the delicious bolo lvedo (Portuguese muffins) are not to be missed.

Marie-Caroline Lefort Cellule de Valorisation Pdagogique, Universit de Tours, Tours, France. Email: marie-caroline.lefort{at}univ-tours.fr

As a Jewish woman born in Iran and living in Israel, I feel connected to the ancient history of my people. Because it is rare to find an Iranian woman in science who keeps Jewish traditions, I feel a responsibility to manifest all the good that is in each part of my background.

My family celebrates the traditional holiday of Rosh Hashanah (the Jewish New Year). Wearing white clothing to symbolize purity, we light candles and look into the flames as we give thanks and ask for blessings in the coming year. We celebrate this contemplative holiday with a festive meal steeped in symbolism and tradition. We eat apples dipped in honey and pomegranates to symbolize our hopes for a sweet, peaceful, happy new year that is full of good deeds. The honey represents sweetness, and the apple tree is the only tree that has more fruit than leaves, reminding us that we should maximize our purpose in this world. The numerous seeds in pomegranates, a native fruit of ancient Persia, symbolize the many good deeds we should carry out during the coming year. We also make a traditional Iranian-Jewish stew out of quince, a native fruit of west Asia (including Iran and Israel) that looks like an apple. The sweet smell fills the entire house with a magical floral and fresh perfume. During Rosh Hashanah, the shofar (an ancient musical instrument typically made of a ram's horn) is blown 100 times. The sound marks the time to make our wishes for the new year, which we read in Hebrew.

My DNA test results show that I am mostly Persian, with a very small percentage (0.8%) of Egyptian in my ancestry. The data echo the Biblical and rabbinical stories that I consider my roots. Our cultural history tells us that our ancestors were in ancient Egypt for hundreds of years before moving to Israel with Moses. In 722 BCE, the Jews were exiled from Israel to other regions, including Iran. My father was born in a city that was first settled by the exiled Jewish people from Israel, and my mom is from a city that is well known in Iran as the site of the story of Esther and Mordechai, traditionally told during the holiday of Purim. My family moved to Israel after the revolution in Iran in 1979. My DNA results mirror both these ancient tales and my own family's story.

Ruty Mehrian-Shai Pediatric Hemato-Oncology, Brain Cancer Molecular Medicine, Sheba Medical Center, Ramat Gan, 52621, Israel. Email: ruty.shai{at}sheba.health.gov.il

I've always struggled with being identified as simply Indian. My name reflects my Indian heritage better than I do, as a Montreal-born, New York City native living in Louisiana. No DNA test could reflect the mix of American and Indian cultural practices that my family has created. Take, for example, American Thanksgiving, which my family co-opted when I was young and combined with a traditional West Bengali feast. At our table, we served the turkey alongside traditional Indian luchi (oil-fried puffed dough) and fusion dishes such as vegetarian shepherd's pie with Indian spices. Because my birthday falls near Thanksgiving, the meal was often followed by a turkey-shaped ice cream cake, Indian sweets like jalebi (a bright orange pretzel of fried sweet dough), gulab jamun (fried syrupy-sweet milk balls), and a spiced tea. We did adhere to the American tradition of overstuffing ourselves with food.

During the holiday, we listened to Bollywood pop, with high-pitched Indian women singing in Hindi or Bengali. Later in the season, my father would mix in some Nat King Cole or Frank Sinatra, or we would play an album from jazz pianist Vince Guaraldi. Being in Queens, I would always play Christmas in Hollis by the Queens-native hip-hop group Run DMC. My parents enjoyed it about as much as I did their Bollywood music, which is to say, not much.

In December, the large extended family of cousins, uncles, and aunts (all with a different honorific based on their birth position relative to my parents) would come over, each removing their shoes at the door out of respect. The men, in sweaters and ties, played bridge cross-legged in a corner on the floor. The women, in saris and their finest gold necklaces and earrings (gaudier than any of the jewelry worn by the hip-hip artists I worshiped), congregated in the dining area, where they teased each other, told stories in Bengali, and prepared meals. Food was served constantly from the moment the first guests arrived until they left. The smell of food cooking, mostly oil and spices, radiated and permeated through every fabric of the house. Chatter, the sounds of food frying, and playful arguing filled every room with noise. Our home was festively decorated; Santa Claus had equal billing with Durga, Kali, and Ganesh.

The kids watched American football or challenged each other to an Indian game called carrom, which is similar to billiards but played on a flat smooth table on the floor. Players use their fingers to flick flat wooden discs into different corner pockets. We would play different tournament styles and use a mix of Bengali and English to taunt and tease each other over missed shots or lucky wins.

Before our current chapter as Americans, my family's Indian past stretches back to time immemorial, but India has a complicated history of invasions and rule. I hoped a DNA test would help clarify some ancestry questions. I wanted the results to say 25% Genghis Khan, 25% Gandhi, 25% Alexander the Great, and 25% unknown. What I got was 64% Central Asian, 30% South Asian, 3% Eastern European, 2% Southeast Asian, and 1% Siberian. So, I could claim Genghis, Gandhi, and Alexander! But of course, not really. I wondered when and where the mingling of my different geographic ancestors took place and if the results were more a reflection of the current genetic reference populations in those areas. The DNA results didn't make me feel differently about my identity, and they were not as interesting as the results I received from a genetic profile that revealed an inversion in one of my chromosomes. That genetic result made me realize how hardy our genomes are and how similar we are as humans; even the 1% or so that makes each of us unique is almost meaningless when considering the bigger picture.

Prosanta Chakrabarty Louisiana State University Museum of Natural Science, Baton Rouge, LA 708033216, USA. Email: prosanta{at}lsu.edu

ILLUSTRATION: MICHELLE KONDRICH

Born in South America, I identify as Latina and have always been aware of my mixed ethnicity. My family's celebration of Christmas and Novena (the previous 9 days, an important observance in Colombia) exemplifies our love of food, music, and dance. During the first 8 days, family and friends meet at different houses to share deep-fried cheesy dough and sweets. On Christmas day and the morning after, we eat homemade Colombian tamales wrapped in plantain leaves and boiled for hours, and we drink hot chocolatefirst adding salty cheese to the mugs and eating it with a spoon once it has melted (a delicacy unique to Bogot, Colombia's capital). Sometimes we also eat cheese arepas (flat corn bread) and almojabnas (cheese bread of Spanish-Arab origin). Meanwhile, my mum prepares about 20 liters of her famous ajiaco, a traditional soup from the Bogota plateau. She uses three kinds of potatoes (one of them endemic to the Northern Andes), guascas (Galinsoga parviflora), corn, chicken, capers, and cream. Toward the end of the day, the whole family gathers for a bowl of ajiaco. We admire our araucaria tree, decorated with lights and ornaments, and the creatively assembled nativity scene (often including llamas, lions, jaguars, and the occasional dinosaur) while waiting for midnight to come.

My family seems to carry music in our blood. There is always a moment when my uncle plays the guitar and everyone else joins in with percussion and voices, singing the melodies of cumbia, vallenato, and bambucomusical styles incorporating strings and accordions from Europe, wind instruments from Indigenous communities, and African drums. The upbeat tunes belie the bittersweet themes in the Spanish lyrics. Soon, everyone is dancing to the energetic, fast-moving rhythms of cumbia, salsa, and merengue. Salsa originated with the Latin and Afro-Latin son cubano and jazz musicians from the Bronx in the United States. The music later made its way to Colombia, where it developed into something new, incorporating cumbia and vallenato elements and a faster dancing style.

I took a DNA test because I work in the fields of population genomics and phylogenomics and thought it would be fun to see my own genome sequences. Half of the sites sequenced on my genome were assigned to populations in Spain, Morocco, and West Africa; the other half to Native American populations. The results were not a surprise, but they encouraged me to dig deeper into my family's history. I wish I could learn about and celebrate the Native American traditions of my ancestors, but most were never documented and are now lost. Important traditions are kept in the Amazon regions, such as chontaduro dancing, where communities share the chontaduro fruit (from the Bactris gasipaes palm) and drinks to celebrate abundance and usher in a good fishing season. Traditions around the cassava, plant growing seasons, and hunting also still take place, but because I grew up in the city, I don't feel personally connected to them. I do take pride in using the words from Quechua, Muisca, and even Arabic languages that have been assimilated into Colombian Spanish.

We knew my grandfather was Indigenous from the south (as the government labeled him back in the day), but the DNA test results suggest that our Indigenous ancestry could have been more recent and likely than we thought. I found the test interesting; I received a set of raw data that I can analyze myself, and the results brought my father and me together in a quest for the documents and stories surrounding my family.

Maria Fernanda Torres Jimenez Gothenburg Global Biodiversity Centre, University of Gothenburg, Gothenburg, Sweden. Email: mftorres27{at}gmail.com

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Beyond DNA: The rest of the story - Science Magazine

Syngenta Crop Protection and Insilico Medicine to Harness Artificial Intelligence to Transform Sustainable Product Innovation – BioSpace

Feb. 3, 2021 07:00 UTC

BASEL, Switzerland--(BUSINESS WIRE)-- Syngenta Crop Protection is collaborating with artificial intelligence (AI) and deep learning company Insilico Medicine to accelerate the invention and development of new, more effective crop protection solutions that protect crops from diseases, weeds and pests, while also protecting ecosystems. By bringing new solutions to farmers faster and more efficiently through innovation, Syngenta will help them meet the ongoing challenges they face, in order to enhance productivity and meet global demand for affordable, quality food.

This collaboration with Insilico Medicine means that Syngenta can harness the immense potential and scope of AI to develop the next generation of sustainable crop protection solutions as part of Syngentas $2bn commitment to innovation and sustainability, said Camilla Corsi, Head Crop Protection Research at Syngenta. This will further transform agriculture by providing farmers around the world with the tools they need to produce healthy, nutritious, affordable and sustainably grown food in the most efficient way, while also minimizing the environmental impact.

Insilico Medicine has a proven track record and has delivered significant advances in pharmaceutical research, using AI and deep learning to design, synthesize and validate new ingredients. The same approach also has the potential to transform the development of new crop protection solutions that help keep plants safe, from planting to harvesting. Working closely with Syngenta, Insilico Medicine will use their AI-powered small molecule generative chemistry technology not only to invent molecules for active ingredients faster, but also actively design molecules that are more sustainable and environmentally friendly.

We are very happy to collaborate with a company that is dedicated to developing safe and sustainable solutions for growers, said Alex Zhavoronkov, PhD, founder, and CEO, Insilico Medicine. Our artificial intelligence is designed from the ground up to produce very precise chemistry to protect human health, while ensuring short-term and long-term safety. This expertise is extremely valuable for crop sciences, and especially so for businesses whose top priority is the safety of their products. Syngenta is a progressive company with many brilliant scientists, and we will be working together to use artificial intelligence for the benefit of agriculture.

Our reputation as a global leader in innovation is built on a foundation of collaboration and our understanding of the challenges faced by growers, Camilla Corsi also noted. Working together with Insilico Medicine, combining our skills, knowledge and technologies, will help ensure that new and more effective crop protection solutions will be in the hands of farmers sooner.

About Syngenta

Syngenta is one of the worlds leading agriculture companies, comprising of Syngenta Crop Protection and Syngenta Seeds. Our ambition is to help safely feed the world while taking care of the planet. We aim to improve the sustainability, quality and safety of agriculture with world class science and innovative crop solutions. Our technologies enable millions of farmers around the world to make better use of limited agricultural resources. Syngenta Crop Protection and Syngenta Seeds are part of Syngenta Group with 49,000 people in more than 100 countries and is working to transform how crops are grown. Through partnerships, collaboration and The Good Growth Plan we are committed to accelerating innovation for farmers and nature, striving for carbon neutral agriculture, helping people stay safe and healthy and partnering for impact.

To learn more visit http://www.syngenta.com and http://www.goodgrowthplan.com

Follow us on Twitter at http://www.twitter.com/Syngenta and http://www.twitter.com/SyngentaUS

About Insilico Medicine

Insilico Medicine develops software that leverages generative models, reinforcement learning (RL), and other modern machine learning techniques for the generation of new molecular structures with specific properties. Insilico Medicine also develops software for the generation of synthetic biological data, target identification, and the prediction of clinical trials outcomes. The company integrates two business models; providing AI-powered drug discovery services and software through its Pharma.AI platform (www.insilico.com/platform/) and developing its own pipeline of preclinical programs. The preclinical program is the result of pursuing novel drug targets and novel molecules discovered through its platforms. Since its inception in 2014, Insilico Medicine has raised over $52 million and received multiple industry awards. Insilico Medicine has also published over 100 peer-reviewed papers and has applied for over 25 patents. Website http://insilico.com/

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Cautionary Statement Regarding Forward-Looking Statements

This document may contain forward-looking statements, which can be identified by terminology such as expect, would, will, potential, plans, prospects, estimated, aiming, on track and similar expressions. Such statements may be subject to risks and uncertainties that could cause the actual results to differ materially from these statements. For Syngenta, such risks and uncertainties include risks relating to legal proceedings, regulatory approvals, new product development, increasing competition, customer credit risk, general economic and market conditions, compliance and remediation, intellectual property rights, implementation of organizational changes, impairment of intangible assets, consumer perceptions of genetically modified crops and organisms or crop protection chemicals, climatic variations, fluctuations in exchange rates and/or commodity prices, single source supply arrangements, political uncertainty, natural disasters, and breaches of data security or other disruptions of information technology. Syngenta assumes no obligation to update forward-looking statements to reflect actual results, changed assumptions or other factors.

2021 Syngenta. Rosentalstrasse 67, 4002 Basel, Switzerland. The Syngenta logo are trademarks of a Syngenta Group Company. All other trademarks are the property of their respective owners.

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Syngenta Crop Protection and Insilico Medicine to Harness Artificial Intelligence to Transform Sustainable Product Innovation - BioSpace

Exploring the Importance of Finding a Molecular Target in Lung Cancer – Targeted Oncology

Brendon Stiles, MD, discusses the current landscape for treating patients with metastatic lung cancer.

Brendon Stiles, MD, a thoracic surgeon at NewYork-Presbyterian Hospital and an associate professor of cardiothoracic surgery at Weill Cornell Medicine, discusses the current landscape for treating patients with metastatic lung cancer.

Stiles states that there is an amazing number treatment options available in the metastatic setting. Understanding the molecular subtype of cancer in patients with metastatic disease is important for their treatment. There are targets such as EGFR,ALK,ROS,BRAF,NTRK,MET, andRET.There are multiple options when targeting rare alterations in this population. He says it gets to that principle of having to look for mutations to know if they are there.

Aside from targeted therapy, some patients are eligible for immunotherapy, which is a completely different paradigm based on PD-L1 expression and combination therapy, according to Stiles.

Stiles sees many patients in the late stages of their disease as part of the initial diagnosis phase or sometimes to perform a diagnostic procedure to uncover metastatic disease. There was a time when there wasnt good prognosis for patients with lung cancer. Now that oncologists have figured out the appropriate therapy for each type of patient, Stiles explains that he would like to see these treatments move into the early-stage setting. This is slowly starting to happen, he says, but its critical to know the histologic and molecular subtype of a patient with stage IV disease.

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Exploring the Importance of Finding a Molecular Target in Lung Cancer - Targeted Oncology

A Closer Look at the AI Hype Machine: Who Really Benefits? – Common Dreams

The poet Richard Brautigan said that one day we would all be watched over by "machines of loving grace". It was a nice sentiment at the time. But I surmise Brautigan might have done a quick 180 if he was alive today. He would see how intelligent machines in general and AI in particular were being semi-weaponized or otherwise appropriated for purposes of a new kind of social engineering. He would also likely note how this process is usually positioned as something "good for humanity" in vague ways that never seem to be fully explained.

As both a technologist and a journalist, I find it very difficult to think of transhumanism and what I'll call the New Eugenics as anything less than deeply and literally dehumanizing.

The hits, as they say, just keep on coming. Recently I ran across an article advising recent college graduates looking for jobs that they had better be prepared to have their facial expressions scanned and evaluated by artificial intelligence programs during and after interviews.

An article in the publication "Higher Ed" warned that: "Getting a job increasingly requires going through an interview on an AI platformIf the proprietary technology [used to ] to evaluate the recordings concludes that a candidate does well in matching the demeanor, enthusiasm, facial expressions or word choice of current employees of the company, it recommends the candidate for the next round. If the candidate is judged by the software to be out of step, that candidate is not likely to move on."

If this were happening in China, of course, it would be much less surprising. You don't have to be a Harvard-trained psychiatrist to see that this kind of technology is violating some very basic human boundaries: how we think and feel and our innermost and private thoughts. And you don't have to be a political scientist to see that totalitarian societies are in the business of breaking down these boundaries for purposes of social and political control.

Facial recognition has already been implemented by some law enforcement agencies. Other technology being used for social control starts out in the corporate world and then migrates. Given the melding of corporate and government power that's taken place in the U.S. over the last few decades, what's impermissible in government now can get fully implemented in the corporate world and then in the course of time bleeds over to government use via outsourcing and other mechanisms. It's a nifty little shell game. This was the case with the overt collection of certain types of data on citizens which was expressly forbidden by federal law. The way around it was to have corporations to do the dirty work and then turn around and sell the data to various government entities. Will we see the same thing happen with artificial intelligence and its ability to pry into our lives in unprecedented ways?

There is a kind of quasi-worship of technology as a force majeure in humanity's evolution that puts AI at the center of human existence. This line of thinking is now linked to the principles of transhumanism, a set of values and goals being pushed by Silicon Valley elites. This warped vision of techno-utopianism assures us that sophisticated computers are inherently superior to humans. Implicit in this view is the notion that intelligence (and one kind of intelligence at that) is the most important quality in the vast array of attributes that are the essential qualities of our collective humanity and longstanding cultural legacies.

The corporate PR frontage for these "breakthroughs" is always the same: they will only be used for the highest purposes like getting rid of plastics in the oceans. But still the question remains: who will control or regulate the use of these man-made creatures?

The most hardcore transhumanists believe that our role is simply to step aside and assist in the creation of new life forms made possible by hooking up human brains to computers and the Internet, what they consider to be an evolutionary quantum leap. Unfortunately, people in powerful corporate positions like Ray Kurzweil, Google's Director of Engineering, and Elon Musk, founder of Neuralink, actually believe in these convoluted superhero mythologies. This line of thinking is also beginning to creep into the mainstream thanks to the corporate-driven hype put forth by powerful Silicon Valley companies who are pushing these ideas for profit and to maintain technology's ineluctable "more, better, faster" momentum.

The transhumanist agenda is a runaway freight train, barely mentioned in the mainstream media, but threatening to run over us all. In related "mad science" offshoot, scientists have succeeded in creating the first biological computer-based hybrids called Xenobotswhich the New York Times describes as "programmable organisms" that "live for only about a week". The corporate PR frontage for these "breakthroughs" is always the same: they will only be used for the highest purposes like getting rid of plastics in the oceans. But still the question remains: who will control or regulate the use of these man-made creatures?In the brave new world of building machines that can think and evolve on their own because they combine AI programming with biological programming, we have to ask where all this is headed. If machines are being used to evaluate us for job interviews, then why won't they be eventually used as police officers or judges? (In fact, Singapore is now using robotic dogs to police parks for Covid-related social distancing.)

As both a technologist and a journalist, I find it very difficult to think of transhumanism and what I'll call the New Eugenics as anything less than deeply and literally dehumanizing. In the aftermath of WWII, eugenics used to be widely reviled when Nazi scientists experimented with and so highly valued it. Now it's lauded as cutting edge.There are two ugly flies in this ointment. The first is the question of who directs and controls the AI machines being built. You can make a safe bet that it won't be you, your friends, or your neighbors but rather technocratic elites. The second is the fact that programmers, and their masters, the corporate Lords of Tech, are the least likely candidates to come up with the necessary wisdom to imbue AI with the deeper human qualities necessary to make it anything more than a force used for social and political control in conjunction with mass surveillance and other tools.

Another consideration is: how does politics fit into this picture? In the middle ages, one of the great power shifts that took place was from medieval rulers to the church. In the age of the enlightenment, another shift took place: from the church to the modern state. Now we are experiencing yet another great transition: a shift of power from state and federal political systems to corporations and, by extension, to the global elites that are increasingly exerting great influence on both, the 1 percenters that Bernie Sanders frequently refers to.

When considering the use of any new technology, the question should be asked: who does it ultimately serve? And to what extent are ordinary citizens allowed to express their approval or disapproval of the complex technological regimes being created that we all end up involuntarily depending upon?

These trends have political implications because they have happened in tandem with the neoliberal sleight of hand that began with President Reagan. Gradually anti-democratic policy changes over a period of decades allowed elites to begin the process of transferring public funds to private coffers. This was done under the neoliberal smokescreen of widely touted but socially hollow benefits such as privatization, outsourcing, and deregulation bolstered by nostrums such as "Government must get out of the way to let innovation thrive."

Behind the scenes, the use of advanced technology has played a strong role in enabling this transition but it did so out of the public's watchful eye. Now, it seems abundantly clear that technologies such as 5G, machine learning, and AI will continue to be leveraged by technocratic elites for the purposes of social engineering and economic gain. As Yuval Harari, one of transhumanism's most vocal proponents has stated: "Whoever controls these algorithms will be the real government."

If AI is allowed to begin making decisions that affect our everyday lives in the realms of work, play and business, it's important to be aware of who this technology serves: technologically sophisticated elites. We have been hearing promises for some time about how better advanced computer technology was going to revolutionize our lives by changing just about every aspect of them for the better. But the reality on the ground seems to be quite different than what was advertised. Yes, there are many areas where it can be argued that the use of computer and Internet technology has improved the quality of life. But there are just as many others where it has failed miserably. Healthcare is just one example. Here misguided legislation combined with an obsession with insurance company-mandated data gathering has created massive info-bureaucracies where doctors and nurses spend far too much time feeding patient data into a huge information databases where it often seems to languish. Nurses and other medical professionals have long complained that too much of their time is spent on data gathering and not enough time focusing on healthcare itself and real patient needs.

When considering the use of any new technology, the question should be asked: who does it ultimately serve? And to what extent are ordinary citizens allowed to express their approval or disapproval of the complex technological regimes being created that we all end up involuntarily depending upon? In a second "Gilded Age" where the power of billionaires and elites over our lives is now being widely questioned, what do we do about their ability to radically and undemocratically alter the landscape of our daily lives using the almighty algorithm?

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A Closer Look at the AI Hype Machine: Who Really Benefits? - Common Dreams

Into The Darkness Is A Promising VR Adventure With Boneworks-Like Physics – UploadVR

Into The Darkness, a new indie VR game from Cosmos Games, promises a compelling story involving transhumanism in the near future merged with exciting VR action-adventure gameplay that uses a Boneworks-like physics system.

Announced this week, the game will be available for PC VR in late 2021, developed by Vietnamese studio Cosmos Games and published by GameBoom VR and PlayWay.

The game takes place in a dystopian sci-fi setting where humans are trying to move consciousness into machines in order to live forever. Heres a summary of the story from Cosmos Games:

Humanity is trying to achieve immortality by transferring consciousness to machines. Transhumanism, however, is a dangerous path, and a poorly conducted experiment can end in a tragedy. As agent Frank, you are sent to one of the research facilities with which contact has been interrupted, and the previous agents never returned. Navigate through environments, solve the puzzle, engage the enemy to find out the dark secret behind the experiments.

You can sneak an early look at the games visuals and gameplay in the announcement trailer embedded above.

As you can see from the trailer, Into The Darkness is looking to implement a comprehensive physics system that works similarly to pioneers in the field like Boneworks. All of the objects have weight and physics that react in a manner consistent with the real world. Towards the end of the trailer, theres even a glance at a Half-Life: Alyx-style glove system that lets you force pull items toward you.

Into The Darkness will launch for PC VR in Q2 of this year, available on Steam for Oculus Rift, Valve Index (including finger tracking support), HTC Vive, and Windows Mixed Reality headsets.

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Into The Darkness Is A Promising VR Adventure With Boneworks-Like Physics - UploadVR

‘Glitchpunk’ will see players take to the neon streets from a top-down view – NME

A new top-down cyberpunk game is set for release in the second quarter of the year.

Glitchpunk is a new top-down action game from studio Dark Lord. Its based on the retro style of GTA and GTA2, the predecessors to the 3D open world GTA games that have in turn inspired modern action games such as Grand Theft Auto 5.

A trailer that explores the action in the game is available via Youtube below:

Glitchpunk pits the player as an android bounty hunter with a glitch that causes them to rebel against their programming, and facing off against the government and megacorps of the dystopian setting.

Like GTA2, the game will have you stealing cars, shooting enemies, sneaking around, and upgrading your body with tech to make you a formidable android.

The developers Dark Lord are aiming to make the game true to the genre, by telling a story that covers transhumanism, xenophobia, and religion with a narrative that lets you influence the world, make friends and find love.

Listed amongst the key features are confirmation that there will trains, tanks, motorbikes and busses, and that the gameplay will take place in four different cities including USA and Russia.

Glitchpunk is going to launch into Steam Early Access in the second quarter of 2021. A Discord server is available for players who want to keep up to date with all the games progress.

As part of the Steam Game festival next week, there will be a demo for Glitchpunk released on February 3.

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'Glitchpunk' will see players take to the neon streets from a top-down view - NME