Will We Ever Fully Understand Humans Impact on Nature? – The Nation

Elizabeth Kolbert. (Photo by John Kleiner)

To say that Earth is in crisis is an understatement. Atmospheric warming, ocean warming, ocean acidification, sea-level rise, deglaciation, desertification, eutrophicationthese are just some of the by-products of our speciess success, journalist Elizabeth Kolbert warns us about in her new book, Under a White Sky: The Nature of the Future. Kolbert has been studying the consequences of humanitys impact on Earth for decades as a contributor to The New Yorker and as the author of such books as the 2015 Pulitzer Prizewinning The Sixth Extinction, an exploration of the concept of extinction that posits mankind as a cataclysm as great as the asteroid that annihilated the dinosaurs.

In Under a White Sky, Kolbert ponders the nature of the future by examining a new pattern she attributes to the recursive logic of the Anthropocene: human interventions attempting to answer for past human interventions in the environment. The book chronicles the casualties of short-sighted human meddling with the planet and its resources and the present-day efforts being made to address that meddlingor, as Kolbert puts it, efforts to control the control of nature. Interviews with scientists in a wide array of disciplinesclimate scientists, climate entrepreneurs, biologists, glaciologists, and geneticistsreveal a trend of projects aiming to transform nature in order to save it. From the Mojave to lava fields in Iceland, Kolbert takes readers on a globe-spanning journey to explore these projects while weighing their pros, cons, and ethical implications (the books title refers to the way the sky could be bleached of color as a potential side effect of solar geoengineering, one of the proposed interventions to combat global warming). The issue, at this point, Kolbert writes, is not whether were going to alter nature, but to what end?

I spoke to Kolbert over the phone the day after President Joe Bidens inauguration. We talked about what its like to write a book about a big question you dont yet have the answer to, and what it will take to undo the environmental damage incurred during the Trump years.

Naomi Elias

Naomi Elias: You describe Under A White Sky as a book about people trying to solve problems created by people trying to solve problems. Can you explain that a little?

Elizabeth Kolbert: The pattern that Im looking at in the book is ways in which humans have intervenedor, if you prefer, mucked around withthe natural world and then have decided that the consequences are bad and are now looking for new forms of intervention to try to solve those problems. I start with the example of the Chicago River, which was reversed in an extraordinary engineering project at the beginning of the 20th century. The Chicago River used to flow east into Lake Michigan, which also happened to be Chicagos only source of drinking water. All of Chicagos human and animal waste flowed into Lake Michigan and there were constant outbreaks of typhoid and cholera. So Chicago decided, Well, we really have to do something about it, and what they did was this incredible engineering project, and now it flows basically to the southwest and eventually into the Mississippi, and all of Chicagos waste flows in the same direction. When the canal that reversed the river was put into place, there was a headline in The New York Times that ran something like, Water Flows in the Chicago River Again. It was so thick with muck that people joked a chicken could walk across it without getting its feet wet. That created a big problem that connected two huge drainage systems, the Great Lakes drainage system and the Mississippi drainage system, that has now led to all these species, including many invasive species, crossing from one basin into the other. It was having bad effects on the ecology of both systems, so to try to prevent these species from crossing from one basin to the other, theyve now electrified a significant chunk of this canal. So thats an intervention, as it were, on top of an intervention, and that is really the pattern that the book explores.

NE: The book visits project sites in Iceland, Australia, New Orleans, and the California desert. What drew you to the projects you write about?

EK: The first project that got me started down this whole path was the super coral project, which is currently in Hawaii and partly in Australia. As the oceans warm, corals are having a lot of trouble surviving. We get these coral-bleaching events that Im sure people have heard about. Some scientists were looking at how we can save coral reefs and the idea they came up with was that we need to intervene and try to coax along evolution so that these creatures can survive climate change. That struck me as a really interesting project, and got me thinking about this question of, Can we intervene to redress our own interventions? Once I started seeing that pattern, I started to see it everywhere. I could have gone to many different parts of the world and written stories that made the same point, but the projects that I went to were emblematic in some way. They were taking on different issues like climate change or invasive species, the loss of wetlandsthe list goes on.

NE: Did any of these effortsbe it the Harvard team trying to combat global warming by firing diamonds into the stratosphere or the group looking to reduce rodent populations with genetic manipulationconvince you that our best chance of averting climate apocalypse really is to control the control of nature? Are we digging ourselves out of a hole or just digging a deeper one?

EK: You know, you have identified the question at the center of the book. That is a question that I dont claim to answer. Im not a prophet. Im really trying to tease out that question in the book. Look at it, and have some fun with it, to be honest, and get people to think about the pattern. In many cases, these solutions are working to a certain extent. New Orleans would not exist without massive human intervention to solve the problems of water. In New Orleansa city thats essentially significantly below sea levelit turns out you need flooding to keep the land from subsiding even further because thats actually what built the land, the flooding that dropped a lot of sediment across the Mississippi Delta over many millennia. Are you getting into a trap when you pile these interventions on top of each other? Do you have alternatives? These are the big questions of our time.

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NE: Id like to talk about your feelings about the popular phrase for the geological epoch were living in, the Anthropocene. In 2017 you gave a lecture at Manhattans New School, in which you said, Thinking scientifically about mans place in the world used to mean acknowledging our insignificance. This new human-centered term, the age of man, completely upends that. Can you talk about your feelings about the term and what it means for how we think about our relationship to the Earth?

EK: I think we are at this interesting turning point thats on some level been the subject of all the books Ive written, and a lot of the articles as well. We first decentered humans, right? It wasnt that the sun revolved around the Earth, it was that the Earth revolved around the sun. Theres a lot of these discoveries that have proved people are not the center of the universe, but then we get to the present moment, where we do have to acknowledge that we are becoming the dominant force in many very essential ways. We have to acknowledge that and, on some level, take responsibility for that. This term, the Anthropocene, is kind of a shorthand for all the ways that humans are affecting the Earth on what is sometimes called a geological scale. We are changing the carbon cycle very dramatically, were changing the nitrogen cycle, were acidifying the ocean. Weve even got to the point where we regularly cause earthquakes. We are definitely driving evolution; we are probably driving speciation. We are at this moment
of tremendous human impact and we need to rise to that challenge of thinking about what we want the world to look like now that we are such a dominant force.

NE: In the book, you take note of the way the scientists you speak to encode a sense of moral urgency into their analysis of the climate crisis, which is something I feel present in contemporary climate reporting too. Youve been on the climate beat for decades. Have you felt a shift in the work? Do you feel like you now have an agenda when you write?

EK: Theres definitely been a shift in the sense that, when I started out almost 20 years ago, there was still, among a lot of pretty knowledgeable people, a lot of confusion. What is climate change? Is it real? Do I have to worry about it? The conversation has moved dramatically, at least in a big chunk of the US and a big chunk of the world. But I do not consider myself an advocate. Im a journalist and I try to report stories that I think illuminate the situation that were in. Ive thought about, you know, Should I be writing some sort of prescriptive journalism? But thats not really me.

NE: At the end of that same 2017 lecture you conclude, We are the fate of Earth. You call humans ethical agents and say that were failing as ethical agents if we dont acknowledge our impact.

EK: Yes, I certainly stand by those words. I mean, this book is on the one hand grappling with, on the other hand sort of playing around with, those questions. Our impact on the planet and the untold number of other species with whom we share the planet and whom we frankly dont spend a lot of time thinking aboutand dont even understand to a great extentI think will come to be seen as one of the great tragedies and the great ethical failings of humanity.

NE: So many of the things you discuss in the book were set in motion long before the 2016 election, but its hard to overstate what a setback the last four years of the Trump administration have been for the climate. An analysis from The New York Times cites over 100 environmental protections Trump reversed concerning areas like wetland and wildlife protection, and air and water pollution. In his inauguration speech yesterday, President Biden talked about answering the cry for survival Earth was letting out, and he immediately signed an order to rejoin the Paris climate accord. Im wondering what your thoughts are on what your job is going to look like under the Biden administration, and if you think we dodged some kind of metaphorical asteroid?

EK: I think what Trump did was egregious. It was an attempt to set us off completely on the wrong trajectory. Its a very complicated situation legally because now a lot of regulations will have to be rewritten. Its going to occupy the EPA for years, unfortunately. Thats very sad and just a waste of time and of human effort, when we should be doing a lot of other things. But, you know, there are great forces at work here and fortunately some of those continue to go in the right direction, like the tremendous decrease in prices of wind power and solar power that continued despite Donald Trumps best efforts to try to undermine renewable power. One could spend the next four years doing nothing but looking at the legal ins and outs of trying to undo that, and I think that that would be a noble thing to do. What Im thinking about areI dont want to call them bigger questions, but theyre the questions of our human impact on the planet, which are not going to change because Joe Biden suddenly rejoined the Paris Agreement, unfortunately.

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Will We Ever Fully Understand Humans Impact on Nature? - The Nation

Could the Immune System Hold the Key To Alzheimer’s Disease? – The Wire Science

Photo: Matt Artz.

For nearly 30 years, the hunt for a cure for Alzheimers disease has focused on a protein called beta-amyloid. Amyloid, the hypothesis goes, builds up inside the brain to bring about this memory-robbing disorder, which afflicts some 47 million people worldwide.

Billions of dollars have poured into developing therapies aimed at reducing amyloid thus far, to no avail. Trials of anti-amyloid treatments have repeatedly failed to help patients, sparking a reckoning among the fields leaders.

All along, some researchers have toiled in the relative shadows, developing potential strategies that target other aspects of cells that go awry in Alzheimers: molecular pathways that regulate energy production, or clean up cellular debris, or regulate the flow of calcium, an ion critical to nerve cell function. And increasingly, some of these scientists have focused on what they suspect may be another, more central factor in Alzheimers and other dementias: dysfunction of the immune system.

With the fields thinking narrowed around the amyloid hypothesis, immunological ideas have struggled to win favour and funding. There was no traction, says Mal Tansey, a University of Florida neuroscientist whose work focuses on immunology of the brain. The committees that review grant applications didnt want to hear about immunological studies, she says.

But over the past decade, the immune system connection to Alzheimers has become clearer. In several massive studies that analysed the genomes of tens of thousands of people, many DNA variants that were linked to heightened Alzheimers risk turned out to be in genes involved in immunity specifically, a branch of the bodys defences known as the innate immune system. This branch attacks viruses, bacteria and other invaders quickly and indiscriminately. It works, in part, by triggering inflammation.

A further connection between inflammation and Alzheimers turned up in March 2020, in an analysis of electronic health records from 56 million patients, including about 1.6 million with rheumatoid arthritis, psoriasis and other inflammatory diseases. When researchers searched those records for Alzheimers diagnoses, they found that patients taking drugs that block a key molecular trigger of inflammation, called tumour necrosis factor (TNF), have about 50 to 70% lower odds of having an Alzheimers diagnosis than patients who were prescribed those drugs but did not take them.

This newer wave of studies opened peoples eyes to the idea that the immune system might be a major driver of Alzheimers pathology, says Sharon Cohen, a behavioural neurologist who serves as medical director at the Toronto Memory Program in Canada. Over time, Cohen says, researchers began thinking that maybe inflammation is not just an aftereffect, but actually a pivotal, early effect.

Tansey is trying to harness this growing realisation to develop new therapies. A drug she helped to develop nearly 20 years ago relieved Alzheimers-like features in mice and recently showed encouraging results in a small study of people with the disease. I think we were onto something way back when, she says.

Early hunch

Tansey got interested in neurodegenerative disease in the late 1990s, while working as a postdoctoral fellow at Washington University in St. Louis. Her research focused on molecules that promote the survival of certain neurons that degenerate in Parkinsons disease in lab dish experiments, anyway. But after six years on a meagre postdoc salary, and with her husband about to start neurology training at UCLA, she took a job at a biotech company in the Los Angeles area, called Xencor. She tackled a project that the company had on the back burner: designing new drugs to inhibit that inflammatory molecule TNF.

At the time, doctors already used two such drugs to treat autoimmune disorders such as psoriasis and rheumatoid arthritis. But these drugs have harmful side effects, largely owing to TNFs complicated biology. TNF comes in two forms: one thats anchored to the membranes of cells, and a soluble form that floats around in the spaces in between. The soluble TNF causes inflammation and can kill cells infected with viruses or bacteria its a necessary job but, in excess, destroys healthy tissues. The membrane-bound form of TNF, on the other hand, confers protection against infection to begin with. The drugs in use at the time inhibited both forms of TNF, leaving people at risk for infections by viruses, bacteria and fungi that typically only cause problems for people with weakened immune systems.

Using genetic engineering, Tansey and her Xencor colleagues designed a drug that prevents this potentially dangerous side effect by targeting only the harmful, soluble form of TNF. It gloms onto the harmful TNF and takes it out of circulation. In tests, injections of the drug reduced joint swelling in rats with a condition akin to arthritis.

By the time the work was published in Science in 2003, Tansey had returned to academia, starting up her own lab at the University of Texas Southwestern Medical Centre in Dallas. And as she scoured the scientific literature on TNF, she began to think again about those experiments shed done as a postdoc, on neurons destroyed during Parkinsons disease. She read studies showing that the brains of Parkinsons patients have high levels of TNF and she wondered if TNF could be killing the neurons. There was a clear way to find out: Put the TNF-blocking drug shed helped to develop at Xencor into the brains of rats that were manipulated to develop Parkinsons-like symptoms and watch to see what happened.

Her hunch proved correct the drug slowed the loss of neurons in Parkinsons rats. And that led Tansey to wonder: Could TNF also be involved in the loss of neurons in other forms of neurodegeneration, including Alzheimers disease? Mulling over the nuanced roles of innate immune cells, which seem to help or hurt depending on the context, she started rethinking the prevailing amyloid hypothesis. Perhaps, she thought, amyloid ends up clumping in the Alzheimers brain because immune cells that would normally gobble it up get sluggish as people age: In other words, the amyloid accumulated as a consequence of the disease, not a cause.

The double-edged nature of immune activity also meant that our immune systems might, if unchecked, exacerbate problems. In that case, blocking aspects of immune function specifically, inflammation might prove helpful.

The idea that blocking inflammation could preserve cognition and other aspects of brain function has now found support in dozens of studies, including several by Tanseys lab. Using an approach that induced Alzheimers-like neurological symptoms in mice, neuroscientist Michael Heneka, a researcher at Germanys University of Bonn, and his colleagues found that mice engineered to lack a key molecule of the innate immune system didnt form the hallmark amyloid clumps found in Alzheimers.

Tansey and colleagues, for their part, showed that relieving inflammation with the drug Tansey helped develop at Xencor, called XPro1595, could reduce amyloid buildup and strengthen nerve cell connections in mice with Alzheimers-like memory problems and pathology. Her team has also found that mice on a high-fat, high-sugar diet which causes insulin resistance and drives up Alzheimers risk have reduced inflammation and improved behavior on tests of sociability and anxiety when treated with XPro1595.

All told, hints from human genetic and epidemiologic data, combined with growing evidence from mouse models, was shifting or pointing toward the role of the immune system, says Heneka, who coauthored a 2018 article in the Annual Review of Medicine about innate immunity and neurodegeneration. And the evidence is growing: In 2019, a study of more than 12,000 older adults found that people with chronic inflammation suffered greater mental losses over a period of 20 years a clue, again, that inflammation could be an early driver of cognitive decline.

The accumulating data convin
ced Tansey that it was time to test this idea in people that instead of targeting amyloid, we need to start targeting the immune system, she says. And it needs to be early. Once too much damage is done, it may be impossible to reverse.

Targeting innate immunity

Immune-based strategies against Alzheimers are already being pursued, but most are quite different than what Tansey was proposing. Companies mostly work with the adaptive immune system, which attacks pathogens or molecules very specifically, recognising them and marking them for destruction. Experimental therapies include antibodies that recognise amyloid and target it for removal.

INmune Bio, in La Jolla, California, is one of several biotech companies taking a different approach: trying to fight degenerative brain disease by targeting the less specific innate immune system. The immune system is a 50-50 partnership, says RJ Tesi, the CEO. If youre about to have a prize fight, youre not going to jump in with one hand tied behind your back. Likewise, with Alzheimers or cancer, you dont want to go into the ring with half the immune system being ignored. To pursue this strategy, INmune Bio bought commercial rights to XPro1595. (Tansey is a paid consultant for INmune Bio but is not involved in any of the companys trials.)

INmune Bio initially focused on cancer, so when it designed its Alzheimers trial, it used a strategy commonly used in cancer drug trials. In Tesis view, a key reason that experimental cancer drugs succeed far more often than experimental neurology drugs is the use of molecular disease indicators called biomarkers. These are measures such as genetic variants or blood proteins that help to distinguish patients who, from the outside, may all seem to have the exact same disease, but may actually differ from one another.

By using biomarkers to select participants, cancer researchers can enrol the patients most likely to respond to a given drug but many neurology trials enrol patients based solely on their diagnosis. And thats problematic, says Tesi, because scientists are coming to realise that a diagnosis of Alzheimers, for instance, might actually encompass various subtypes of disease each with its own underlying biology and each, perhaps, requiring a different treatment.

In an ongoing trial of XPro1595, INmune Bio aims to enrol 18 people with mild to moderate Alzheimers disease, all of whom have elevated levels of biomarkers for excessive inflammation, including one called C-reactive protein. In July, the company reported early data from six participants who were treated with the TNF inhibitor once a week for 12 weeks and assessed for brain inflammation using a specialised magnetic resonance imaging (MRI) technique.

Over the 12-week period, brain inflammation fell 2.3 percent in three participants who received the high-dose TNF inhibitor compared with a 5.1 percent increase in 25 Alzheimers patients whose data were collected previously as part of a major long-term study of Alzheimers disease. Three participants who got a low dose of XPro1595 had a smaller 1.7% increase in brain inflammation. In this small trial, the researchers did not track changes in cognition. But their MRI analysis showed that inflammation was reduced by about 40 percent in a particular bundle of nerve fibres called the arcuate fasciculus that is important for language processing and short-term memory.

Its early days, Cohen says interim results in just six people. However, in a small sample size like that, you might not expect to see anything. Past studies of anti-inflammatory drugs did not show a benefit in Alzheimers patients, but scientists are now reexamining these trial failures, Cohen says. Maybe the idea of the immune system is important, but our therapies were too blunt, she says.

Its not just INmune Bio that has researchers excited about the prospect of tinkering with innate immunity to tackle brain disease. Alector, a South San Francisco biotech company, is developing potential therapeutics to activate the innate immune system to fight Alzheimers. Some of their experimental drugs are intended to boost the activity of innate immune cells in the brain called microglia. Tiaki Therapeutics in Cambridge, Massachusetts, meanwhile, is using computational methods to identify potential treatments for people with neuroinflammatory diseases who have specific gene signatures. And another company, Shanghai-based Green Valley, is investigating a drug that includes a mix of seaweed sugars that, the company claims, alters gut bacteria to tamp down brain inflammation.

Its encouraging to see so many different approaches to harnessing the innate immune system to fight Alzheimers, Heneka says. He predicts, however, that a variety of treatments will be needed to tackle such a multifaceted, complicated disease.

But Tansey suspects that chronic inflammation is a crucial factor that takes a toll on the brain over the course of many years. Although lowering inflammation will not solve everything, she says, I think it will buy you a lot. Because its the dark passenger of the journey.

This article originally appeared in Knowable Magazine, an independent journalistic endeavour from Annual Reviews.

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Could the Immune System Hold the Key To Alzheimer's Disease? - The Wire Science

Global Pharmacogenomics Market To Witness An Outstanding Growth By 2027||Thermo Fisher Scientific Inc, OPKO Health, Inc, Teva Pharmaceutical…

The pharmacogenomics report published by Data Bridge Market research is the representation of data and analysis of the market. It gives detailed analysis of the current market scenario and a market forecast till 2026. The data included in this pharmacogenomics report provides detailed information of the geographic landscape, competitive scenarios and upcoming opportunities in the Industry. The inclusion of the statistical records in the pharmacogenomics report helps in authenticating the results that are being presented and thus provide a clear vision and indication to clients in understanding the response of the participants.

Global pharmacogenomics market is expected to gain market growth in the forecast period of 2020 to 2027. Data Bridge Market Research analyses the market is growing at a healthy CAGR in the above-mentioned research forecast period. Emerging markets and huge investment in research and development are the factors responsible for the growth of this market.

Get Full PDF Sample Copy of Report: (Including Full TOC, List of Tables & Figures, Chart)@ https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-pharmacogenomics-market&kb

The major players covered in the global pharmacogenomics market are Abbott, AstraZeneca, Bayer AG, F. Hoffmann-La Roche Ltd, Thermo Fisher Scientific Inc, OPKO Health, Inc, Teva Pharmaceutical Industries Ltd, Myriad Genetics, Inc., QIAGEN,OneOme, LLC, Illumina, Inc, Empire Genomics, LLC, and Dynamic DNA Laboratories among others.

Global Pharmacogenomics Market Scope and Market Size

Pharmacogenomics market is segmented on the basis of technology, application, end-users and distribution channel.

Patient Epidemiology Analysis

Pharmacogenomics market also provides you with detailed market analysis for patient analysis, prognosis and cures. Prevalence, incidence, mortality, adherence rates are some of the data variables that are available in the report. Direct or indirect impact analysis of epidemiology to market growth are analysed to create a more robust and cohort multivariate statistical model for forecasting the market in the growth period.

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Pharmacogenomics Market Country Level Analysis

Pharmacogenomics market is analysed and market size information is provided by country, technology, application, end-users and distribution channel as referenced above.

The countries covered in the global pharmacogenomics market report are U.S., Canada, Mexico in North America, Brazil, Argentina, Peru, Rest of South America, as part of South America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Hungary, Lithuania, Austria, Ireland, Norway, Poland, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Vietnam, Rest of Asia-Pacific, Saudi Arabia, in the Asia-Pacific, U.A.E, Egypt, Israel, Kuwait, South Africa, Rest of Middle East and Africa, as a part of Middle East and Africa.

North America has been witnessing a positive growth throughout the forecasted period due to the presence of refined healthcare expenditure and increased patient awareness level as well as preference personalized medicines. Europe is considered a second largest growing regional segment owing to the growing geriatric population and rising prevalence of chronic diseases.

Points Involved in pharmacogenomics Market Report:

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Insights of the Study

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Global Pharmacogenomics Market To Witness An Outstanding Growth By 2027||Thermo Fisher Scientific Inc, OPKO Health, Inc, Teva Pharmaceutical...

Pharmacogenomics Market Growth, Competitive Landscape, Research Methodology, Business Opportunities, Statistics and Industry Analysis Report by 2027 …

The major driving factors for the growth of this market in the North American region is the rising demand for personalized medicines, high medical reimbursement facilities, and technological advancement.

The Pharmacogenomics market analysis report ismainly focused on leading market players. Our analysts have provided information on financial statements of these players, product benchmarking, and their key business development strategies.

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Key participants include Abbott Laboratories, Admera Health, LLC, Agena Biosciences, Inc., Cancer Genetics, Inc., Dynamic DNA Laboratories, F. Hoffmann-La Roche Ltd, geneOmbio Technologies Pvt Ltd., Genomic Health, Inc., Illumina, Inc., and Laboratory Corporation of America Holdings, among others.

Pharmacogenomics Market Overview:

The latest market study broadly segments the industry based on the product type range, application gamut, end-use industry, key regions, and the competitive background. One of the central components of the report is a detailed explanation of the gross profits, revenue shares, sales volume, manufacturing costs, individual growth rate, and the financial standing of the leading market players. The developmental scope of the Pharmacogenomics markets new entrants and established companies has also been emphasized in the report.

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Product and Services Outlook (Revenue, USD Billion; 2017-2027)

Products

Kits

Assays and Reagents

Instruments

Software

Services

Genotyping

SNP Identification

Pharmacogenetic Testing

Other Services

Technology Outlook (Revenue, USD Billion; 2017-2027)

Polymerase Chain Reaction (PCR)

Real-Time PCR

qPCR

Digital PCR

DNA Sequencing/Next Generation Sequencing (NGS)

Nucleic Acid Amplification Tests (NAATs)

Mass Spectrometry

Gel Electrophoresis

Hybridization

Fluorescence In Situ Hybridization (FISH)

Chromogenic In Situ Hybridization (CISH)

Others

Microarray

Others

Application Outlook (Revenue, USD Billion; 2017-2027)

Oncology

Infectious Diseases

Neurology/Psychiatry

Cardiovascular

Others

End-Use Outlook (Revenue, USD Billion; 2017-2027)

Research Organization

Pharmaceutical Companies

Diagnostic Centers

Others

In market segmentation by geographical regions, the report has analysed the following regions-

North America (USA, Canada and Mexico)

Europe (Germany, France, UK, Russia and Italy)

Asia-Pacific (China, Japan, Korea, India and Southeast Asia)

South America (Brazil, Argentina, Columbia etc.)

Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

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Table of ContentChapter 1. Methodology & Sources1.1. Pharmacogenomics Market Definition1.2. Research Scope1.3. Methodology1.4. Research Sources1.4.1. Primary1.4.2. Secondary1.4.3. Paid Sources1.5. Pharmacogenomics Market Estimation TechniqueChapter 2. Executive Summary2.1. Pharmacogenomics Market Summary Snapshot, 2021-2028Chapter 3. Pharmacogenomics Market Key InsightsChapter 4.Pharmacogenomics Market Segmentation & Impact Analysis4.1.Pharmacogenomics Market Segmentation Analysis4.2. Pharmacogenomics Industrial Outlook4.2.1. Market indicators analysis4.2.2. Pharmacogenomics Market drivers analysis4.2.3. Pharmacogenomics Market restraints analysis4.3. Technological Insights4.4. Regulatory Framework4.5. Porters Five Forces Analysis4.6. Competitive Metric Space Analysis4.7. Price trend Analysis4.8. Covid-19 Impact Analysis

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Gravity Diagnostics Coordination with Kentucky Department of Health Leads to Findings of First Cases of UK COVID-19 Variant Identified in the State -…

COVINGTON, Ky., Jan. 28, 2021 /PRNewswire/ -- On Tuesday, January 26th, Governor Andy Beshear's office announced that the first two cases of a more contagious variant of coronavirus, first identified in the United Kingdom, have been confirmed in Kentucky. Local Covington-based Gravity Diagnostics began coordinating with the Kentucky Department of Health weeks ago to submit specimens with a unique detection pattern for sequence analysis. This led to the discovery announced on Tuesday by Beshear's office. Dr. Steven Stack, commissioner for public health for the Commonwealth of Kentucky, thanked the laboratory during the Governor's press conferenceWednesday afternoon.

Background from Gravity Diagnostics on detection of SARS-CoV-2 emerging variants Gravity Diagnostics utilizes a molecular test for the detection of SARS-CoV-2. Our test relies on specific RNA sequences for the identification of the virus in clinical specimens. However, RNA viruses, such as SARS-CoV-2, mutate resulting in changes to their RNA sequence. One specific mutation in the S-gene is associated with an increased risk of transmission, the B.1.1.7 variant. This variant contains a deletion in the S-gene which can impact the detection of SARS-CoV-2 with molecular tests.

Impact on Gravity Diagnostics SARS-CoV-2 RT-PCR Assay (EUA202301) Gravity Diagnostics utilizes a modification of the ThermoFisher TaqPath COVID-19 Combo Kit for our SARS-CoV-2 testing. Their methodology detects three distinct genes (S-gene, N-gene, ORF1ab) in the SARS-CoV-2 viral genome, which offers a built-in redundancy for detection of the virus. They have become aware that certain variants will not have the S-gene amplify, but the other two targets will detect the SARS-CoV-2 virus. Analysis by the FDA suggests no impact to the overall sensitivity of the assay. In fact, they can use this pattern of detection to possibly track new variant spread. Once this was known, they began to coordinate with the Kentucky Department of Public Health to submit specimens with this detection pattern for sequence analysis. This information will be used to prepare public health officials with contact tracing and potentially prevent further spread of infection.

"I reached out to our Director of Research and Development, Ryan Walker, PhD., in late December to begin research on how we could start testing for and tracking the SARS-CoV-2 variants. At Gravity part of our core mission is always to go beyond testing samples and reporting results to being a part of a larger, more comprehensive solution that makes a positive impact on and protects our community. With the pandemic, one way we are doing that is by providing more information to the experts who are tracking and coordinating efforts in the field, not just the baseline 'positive and negative' test results. This recent assistance in the discovery of the first two variants of the U.K. strand is a testament to the dedication and expertise of our clinical team. I could not be prouder and we will continue to expand and support these efforts," said Julie Brazil, chief operating officer at Gravity Diagnostics.

About Gravity Diagnostics Gravity Diagnostics is a full-service state-of-the-art CLIA laboratory licensed in all 50 states providing innovative laboratory testing in the areas of COVID-19, Upper Respiratory, Toxicology, Pharmacogenomics, and Sexually Transmitted Infections. We are an advocate for physicians, patients, and our communities, supporting them with unsurpassed integrity, regulatory compliance, and clinical expertise. We currently service over 750 customers from small private practices, to universities, to Fortune 500 companies. Media contact: [emailprotected]. For more information, visit http://www.gravitydiagnostics.com.

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Global Genotyping Assay Market Factors Boosting Industry To Record An Impressive Growth The Courier – The Courier

The report titled Genotyping Assay Market by Products & Services (Reagents & Kits, Genotyping Services, Instruments, and Bioinformatics), by Technology (PCR, Microarrays, Sequencing, Capillary Electrophoresis, MALDI-Tof MS, and Others), by Application (Pharmacogenomics, Di utilizing diverse methodologies aims to examineand put forth in-depth and accurate data regarding the globalGenotyping Assay Market.To begin with, the report comprises the major players actively participating and competing within theGenotyping Assay Market; it entails several companies, manufacturers, suppliers, organizations, and so on. Thus, the report will assist in understanding the initiatives and approaches implemented by these players to create and reinforce their market presence.The report is segregated into different well-defined sections to provide the reader with an easy and understandable informational document. Further, each section is elaborated with all the required data to gain knowledge about the market before entering it or reinforcing their current foothold. The report is divided into:

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The key major market players include:Thermo Fisher Scientific, Inc., Illumina, Inc., Roche Diagnostics Limited, Danaher Corporation, Qiagen N.V., Fluidigm Corporation

The report encompasses the leading manufacturers along with their respective share in the global market in terms of revenue. Moreover, it mentions their tacticalsteps in the last few years, leadership changes, and product innovationinvestmentsto help in making well-informed decision and also to stay at forefront in the competition.

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Global Genotyping Assay Market Factors Boosting Industry To Record An Impressive Growth The Courier - The Courier

It’s Time To Stop Feeding The Exalted Presidency Federalist #2 – The Federalist

For more than a century, presidents have expanded the powers of the executive branch while Congress holds the door open. Compounding the problem, an increasing number of Americans see the person who occupies the presidency as an avatar with whom they should place their value, their hopes, and even their sense of purpose.The result has been disastrous.

Embracing a monarchical spirit in everything but name has pulled people away from tending to their local communities, fueled cults of personality, and done great harm to the checks and balances designed to protect our political system.

Borne by the overreaches of the Nixon administration, Arthur M. Schlesinger Jr. began referring to the executive branch of the American regime as the imperial presidency. Lamentably, despite a few brief interludes, weve witnessed the nations chief executive transform into something worse: The exalted presidency.

Leaders of the White House have become messianic figures to their political and media allies; their missteps and failures are explained away by a majority of their voters, and they receive more and more delegated power from a cowardly U.S. Congress that continues to shrink from its constitutional duties.

How we fix this will be an integral part of any attempt to restore balance to our republic. Indeed, reversing this trend is one of Americas best hopes to roll back the growing sense of disunity that plagues society. First, however, we need to know what we have to return to, and why we should.

Just as the ancient Romans overthrew their last king in favor of a republic in c. 509 B.C., the American Revolution was a denunciation of monarchy in total, not merely a rejection of King George III. Our Founders rightly identified monarchs as emblems of corruption, recognizing that one-man-rule as a way of governing was fundamentally wrong and incompatible with a society that values freedom.

As when Lucius Tarquinius Superbus was deposed, rule by kings was the normal state of affairs for the vast majority of the world when the Declaration was signed in the summer of 1776. One of the seminal characteristics of both the Roman and American republics was their courageous and firm understanding that they were choosing to be set apart from the ways of other nations.

The American government was designed to be representative of the will of the people and granted legitimacy via their enlightened consent. Safeguards, checks, balances, and divisions of power were established to deter both the dominance of a passionate, intemperate mob and of a single individual.

Although the esteemed Roman senator Cato the Elder spoke for the Roman Republic, his words apply all the more to our own American Republic two millennia later:

The reason for the superiority of the constitution of our city to that of other states is that the latter almost always had their laws and institutions from one legislator. But our Republic was not made by the genius of one man, but of many, nor in the life of one, but through many centuries and generations.

In republics both ancient and modern, reason and historical evidence repeatedly prove the greatest threat to liberty comes from concentrated power.

Americans used to hold tightly to a deep-rooted, enduring suspicion of concentrated power of any kind especially when it crept into the presidency. Unfortunately, that well-earned wisdom didnt last past the 19th century. By the 20th century, as George Reedy writes, the presidency had taken on all the regalia of monarchy except ermine robes, a scepter, and a crown.

In his work The Spirit of the Laws, Montesquieu rightly observes, There can be no liberty where the legislative and executive powers are united in the same person.Forty years later in Federalist No. 46, James Madison echoes his concern:

The accumulation of all power, legislative, executive, and judiciary in the same hands may justly be pronounced the very definition of tyranny.

With its origins dating back to Progressive President Theodore Roosevelt, the innocently named yet insidiously pernicious stewardship theory of presidential power threatens to further weaken the already eroded safeguards barely holding our republic together. In his 1913 autobiography, TR offers up his justification for the more hands-on Progressive approach he took while occupied the Oval Office:

I acted for the public welfare, I acted for the common well-being of all our people, whenever and in whatever manner was necessary, unless prevented by direct constitutional or legislative prohibition.

For TR, the president was to be a steward of the people bound actively and affirmatively to do all he could for the people and not to content himself with the negative merit of keeping his talents undamaged in a napkin.

Yet his successor, William Howard Taft, took up a position far more in line with the original intent of the Constitution and vision of the separation of powers desired by the Founders. In 1916, in the book Our Chief Magistrate and His Powers, Taft writes:

The President can exercise no power which cannot be fairly and reasonably traced to some specific grant of power of justly implied and included within such express grant as proper and necessary to its exercise.

Unlike TR, who viewed the presidency as an office imbued with nearly limitless undelineated powers, Taft explains:

There is no undefined residuum of power which he can exercise because it seems to him to be in the public interest. The mainspring of such a view is that the Executive is charged with responsibility for the welfare of all the people in a general way, that he is to play the part of a Universal Providence and set all things right the wide field of action that this would give to the Executive one can hardly limit.

Barely five years leaving office, TRs belief in a powerful presidency filled with a grandiose persona was the template exploited by arch-Progressive Woodrow Wilson.

During the span of just two administrations, the occupant of the Oval Office went from executing laws to writing them corralling the whole U.S. government to do his will.

Wilson expanded on TRs blank-check stewardship approach, believing America needed a leader who could arouse and harness lies waiting to be stirred. For Wilson, whole masses of men were to be like clay in the hands of a Great Leader:

The competent leader of men cares little for the interior niceties of other peoples characters: he cares much-everything for the external uses to which they may be put. His will seeks the lines of least resistance; but the whole question with him is a question of the application of force. They have no thought for occasion, no capacity for compromise.

As Charles Kesler has noted, in 12 of the 14 instances the Federalist Papers mention the word leader or leaders the word is used negatively associating leaders with demagoguery, factionalism, and vice.

Since the United States is, at its core, a nation founded on self-government and small-r republicanism, Wilsons insistence that the country ought to be led by a great Leader of Men is not only misguided but a complete departure from Americas philosophical and political moorings.

During the last century, weve allowed the presidency to be turned into precisely the entity that Wilson wanted it to be, a turn of events that should fill us with shame. Wilsons vision of the presidency was taken up by FDR in 1932 through his New Deal program, then further expanded by President Lyndon B. Johnson in 1964.

By the time of the election of Barack Obama, the presidency had not just assumed Johnsons Great Society manta of being the source of all future healing promising not just to end poverty, but abstractions like loneliness itself but had become a full-blown celebrity outfit catering to egotistical personalities surrounded by legions of adoring and undyingly loyal cheerleaders.

Oprah Winfrey dubbed Obama The One. Columnist Mark Morford called Obama a Lightworker, an attuned being to help usher in a new way of being on the planet.Ezra Klein couldnt contain himself after the 2008 Iowa Caucuses, saying of Obama, He is not the Word made flesh, but the triumph of word over flesh, over color, over despair.

Not to be outdone by his fawning admirers, Obama himself claimed to be able to repair this world and fundamentally transform the United States of America, and audaciously proclaimed his triumph marked the moment when the rise of the oceans began to slow and our planet began to heal.

As for the successive administration, Hogan Gidley, the former national press secretary for Donald Trumps re-election campaign, referred to Trump as the most masculine man to ever hold the White House. Senior advisor Stephen Miller called Trump the most gifted politician of our time and the best orator to become president in generations. In his most recent book, writer Victor Davis Hanson goes so far as to liken Trump to Achilles, Augustus, Martin Luther, and Julius Caesar (meant as a compliment).

Trump himself asserted theres nobody bigger or better at the military than I am, maintainedat his 2016 Republican National Convention speech that only he could fix what ailed America, and proclaimed he was a Presbyterian Christian who never asked God for forgiveness.

The humility and grace of statesmen like George Washington or Abraham Lincoln is a tall order for anyone to emulate, but both Obama and Trump fell far short of the humble dignity the office of the presidency demands. Consequentially, the imperial presidency became an exalted one. With the levels of worshipful praise that weve witnessed during the last two presidencies, the detrimental nationalization of our politics shouldnt shock us one bit.

Criticisms of Obama or his policies, no matter how justified, were reflexively cited as proof of ones conscious (or unconscious) racism, essentially shielding Obama from tangible condemnation.

Plainly, any broad-brush insults or attacks on large, heterogeneous segments of the American population should be denounced. Yet, similar to the reflexive racism defense lobbied at Obamas detractors, in Trumps late-presidency and now ex-presidency periods, criticism of Trumps actions or policies is routinely cited by Trumps die-hard defenders as evidence of ones supposed disdain for the 74 million Americans who voted for him.

Like the Obama racism! retort, this has the effect intended or not of heading off any condemnation of Trump at the pass. Truly, if criticizing president X means you hate all those who voted for X becomes a permanent, reoccurring defense, then engaging in serious political debates or holding Americas chief executive to account will be nearly impossible.

Both catch-all, cover-all rebuttals Youre just racist! and You just hate his voters! are antithetical to the discourse intended by our Founders to keep our republic functioning. We have no kings here. Presidents, like any other politician, should be applauded when they do good and decried when they err. Indeed, as Lord Acton reminds us, There is no worse heresy than that the office sanctifies the holder of it.

No one is supposed to be above the law or above criticism and reproach presidents least of all. Because of the immense power and influence they wield, the president should be the most critiqued and prodded citizen in the country, if for no other reason than it will make them better at the gravely serious job before them.

Regrettably, however, while were only in the second full week of Joe Bidens tenure, it looks like the exalted presidencyis set to continue with the 46th president.

Of course, the legislative branch needs to get back to the business of legislating rather than delegating its powers to the other branches. Congresss decades-long dereliction of its Constitutional duties have added to the bloated largess of the administrative state and enabled them to dodge taking stances on difficult but pressing issues while posing for photo ops and fishing for viral social media clips.

The executive branch needs to get back to taking care that the U.S. Constitution and the laws of the nation are being faithfully executed rather than abusing executive orders as a way to bypass Congress from the legislative process entirely.

Yes, in the final analysis, what we need is for the separate branches of our republic to re-assert and re-assume their proper roles as envisioned by the Founders and articulated in Articles I, II, and III of the Constitution. The brilliant political machinery of the American republic isnt broken. Whats broken is our capacity for self-rule.

Little by little, weve come to expect less of ourselves while placing more of our purpose and hopes with whoever resides in the White House.

The fault, dear Brutus, is not in our stars, but in ourselves, that we are underlings.(Julius Caesar, Act I, Scene III)

Even strong leg muscles will atrophy after decades of neglect, requiring crutches in order to walk. After surrendering the responsibility of self-government for so long, the presidency has become the crutch where we rest the burdens that used to be shouldered by our communities, our families, and our places of worship. The problem is, however, that the harder we lean on this crutch, the harder it is to get back up on our own two feet, and the more we sink into a posture that looks a whole lot like servitude.

As Schleisinger Jr. wrote back in 1973, When presidents begin to succumb to delusions of grandeur, when the checks and balances inside themselves stop operating, external checks and balances may well become necessary to save the republic. Realistically, however, as most such measures would require constitutional amendments, for the time being, it seems highly likely any sort of major reforms to the office of the presidency will continue to exist only in the realm of political what if fantasyland.

Instead, the solution must come from us.We the people must be the check on the presidency. We the people must demand Congress take back its role as the preeminent branch of government. We the people must starve presidents of the attention and absolute loyalty they now crave. We the people must roll back and curtail the unbridled reverence of the presidency that has warped the Oval Office.

Through the power of our collective voices and votes, we the people must begin to rescind the exalted presidency, and rediscover our quintessentially American antipathy towards monarchs no matter if their official title isnt king but president.

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It's Time To Stop Feeding The Exalted Presidency Federalist #2 - The Federalist

The Real Greenhouse-Gas Polluter Isn’t The United States, It’s China – The Federalist

With President Biden signing a series of executive orders aimed at combating climate, he appears more than willing to sacrifice both the economy and good-paying American jobs to theoretically reduce greenhouse gas (GHG) emissions. Bidens climate czar, John Kerry, seems to believe America must have Chinas cooperation to succeed in emissions reduction.

Yet, according to the latest United Nations Emissions Gap Report 2020, Biden and Kerry couldnt be more wrong. In truth, the United States has done more for reducing GHG emissions than China ever has, and China is neither a leader nor a reliable partner on this issue.

The United Nations Environment Programme releases the annual Emission Gap Report to assess the gap between projections of greenhouse emissions in 2030 and where they should be if countries implement their climate mitigation pledges. In a sense, the report yearly nags nations to move toward the temperature goals of the Paris Agreement.

The objective of the accord is to reduce man-made greenhouse gas emissions to limit global warming to 3.6 degrees Fahrenheit, or 2 degrees Celsius. Former President Obama committed the United States to the Paris Climate Accord in 2015, and regarded the Paris Climate Accord as one of his legacy projects, even refusing to issue a permit to the Keystone XL pipeline.

Obamas reasoning? That the pipeline would generate so many GHG emissions it would jeopardize Americas commitment to the Paris Accord, even though his own State Department found no evidence to support such a claim after conducting five studies in seven years.

The Heritage Foundation estimates the United States commitment to the Paris Accord would cost the average American family of four $20,000 and the national gross domestic product $2.5 trillion by 2035 while achieving an insignificant amount of reduction in global temperature.

In 2017, President Trump pulled the United States out of the Paris Accord, an action he explained to be both in Americas economic interest and wont matter much to the climate. He also vowed that under his administration, the United States would continue to be the cleanest and most environmentally friendly country on Earth.

Needless to say that his decision was widely condemned by environmental activists, progressive groups, celebrities, corporate America, and many of our allies. Kerry called Trumps action an abdication of leadership and self-destructive.

Now, the verdict is in not from any right-wing source, but the latest climate report released by the United Nations. In combating GHG emissions, theres nothing but good news to report about the United States.

The United States overall GHG emissions have been in decline (0.4 percent per year) over the last decade, while those of China continue to spike up, growing at an average of 2.4 percent per year. Although the GHG emissions on a per capita basis in the United States is still the highest in the world, the number is coming down sharply while those of other major economies such as China and India are trending up.

Whats especially noticeable is GHG emissions in the United States continued to go down even after the Trump administration withdrew from the Paris Accord. The continued reduction came when the United States was experiencing a booming economy and the construction of the Keystone XL pipeline was underway.

The first lesson from the U.N. climate report is that the United States is on a good trajectory to address climate-related issues and has made consistent and meaningful progress. As a nation, the United States does not have to sacrifice its economy and the jobs of American workers to protect the environment. Unfortunately, however, President Biden has already ignored this lesson, with his Day One executive order directing the United States to rejoin the Paris Accord.

In contrast to the good news out of the United States, the U.N. report presented some glooming news for those who remain within the Paris Accord: global greenhouse gas emissions continued to grow for the third consecutive year in 2019. Although GHG emissions are expected to come down in 2020 mainly due to worldwide lockdowns in response to the coronavirus pandemic, the EG report believes such a one-year reduction will have an insignificant impact on global temperature.

The main culprit of this worsening trend is China, a nation that emits more than one-quarter of global GHG emissions and has per capita emissions that are around 40 percent above the global average. Indeed, Chinas annual GHG emission is almost equivalent to the sum of those of the United States of America, EU27+UK, and India.

Despite all of the evidence indicating China is the biggest polluter of this planet, Chinas leader, Xi Jinping, knows how to talk the green talk to appeal to left-wingers in the west while doing nothing they actually want on this issue.

When the United States withdrew from the Paris Accord in 2017, Xi wasted no time in offering China as an alternative to the United States. He cast himself as the new leader on climate change. He said: The Paris agreement is a milestone in the history of climate governance. We must ensure this endeavor is not derailed China will continue to take steps to tackle climate change and fully honor its obligations.

The Global Energy Monitor estimates that China will need to reduce its coal power capacity by 40 percent over the next decade to meet its climate goal as stated in the Paris agreement. Yet the opposite happened. Since signing up for the Paris Accord, China has built more new coal plants inside China than any other country, just as its coal plant capacity is expected to increase 10 percent by 2025.

Additionally, the Chinese government made building coal-fired power plants abroad a top priority within its controversial global infrastructure program, Belt and Road. According to Edward Cunningham, a specialist on China at Harvard University, China is building or planning more than 300 coal plants in places as widely spread as Turkey, Vietnam, Indonesia, Bangladesh, Egypt, and the Philippines.

Some accuse China of exporting pollution to boost its economy. Besides environmental concerns, the National Public Radio reported that more than 25 percent of coal plants outside China that are under construction by Chinese contractors are financed by Chinese state-owned financial institutions. Poorer nations that cant pay back their Chinese loans may have to trade their strategic assets to China to pay off their debt.

While the facts on the ground contradict Xis lofty rhetoric, they havent prevented Xi from making an even loftier promise at last years U.N. gathering, Xi pledged that China would be carbon neutral by 2060.

Although todays Chinese government has a long history of making promises it has no intention of keeping, it hasnt stopped some leftists in the west from taking Xis empty promise at face value once again. In exchange for Chinas cooperation on climate change, some on the left are willing to pretend they do not notice the gross human rights violations the CCP has committed, such as the genocide of Uighur Muslims in Xinjiang.

When defending the controversial European Union-China investment agreement, which some critics say compromised the EUs human rights credibility, Ursula von der Leyen, president of the EU-Commission, specifically mentioned one of the motivations behind signing on this deal is to protect our climate under #ParisAgreement. She never mentioned Uighurs or Hong Kongers in her Twitter thread.

Unfortunately, Kerry seems to share Ursulas faith in China. Kerry reportedly believes cooperation with China is the key to progress on climate change and that climate is by far the most important issue in the relationship between the United States and China. This is the same belief he held as secretary of state under President Obama. He couldnt be more wrong.

The worst part is that Beijing is fully aware of Kerrys eagerness to strike a deal on climate change and will take advantage of it. Beijing certainly hopes a negotiation on climate change will distract the United States from focusing on other strategic areas that are far more important to the Communist regime, such as Beijings long-desired reunification with Taiwan. According to The Atlantic, even some of Kerrys liberal colleagues are worried: Chinas diplomacy is a constant search for leverage, and Kerry will deliver a load of it in a wheelbarrow right to their front door every day.

Lets hope President Biden will at least learn from this U.N. report that China is neither a leader nor a reliable partner in addressing climate-related issues because its lofty rhetoric is not supported by its actions. Therefore, the Biden administrations China policy should reflect facts on the ground rather than wishful thinking, and never sacrifice national security nor the U.S. economy for Chinas empty climate promises.

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The Real Greenhouse-Gas Polluter Isn't The United States, It's China - The Federalist

Dems Tried To Use COVID Relief Bill To Pass Amnesty For Illegal Aliens – The Federalist

Speaker of the House Nancy Pelosi denied House Democrats requests to include amnesty for illegal immigrants who served as essential workers during the pandemic in President Joe Bidens $1.9 trillion COVID-19 relief bill.

President Biden proposed comprehensive immigration reform, which includes protections for frontline immigrant workers, separate from his Covid relief plan, and we expect that to therefore have separate consideration, a House Democratic leadership aide told Politico.

Pelosis brisk response follows a letter from 100 Democratic representatives urging the speaker and other House leaders to consider slipping in a faster path to citizenship for the more than 5 million Dreamers, Temporary Protected Status recipients, and undocumented immigrants who have helped keep Americans healthy and safe during the pandemic and are critical for our economic recovery.

As we continue to confront a public health and economic catastrophe that will soon have claimed the lives of more than 450,000 Americans [and] exacerbated deep racial, gender, and economic inequities, it is vital that we include protections for immigrant workers to secure the health of our nation and lay the foundation for a robust and dynamic economic recovery, the letter from the Hispanic Caucus read.

Just a month before the Hispanic Caucuss letter, hundreds of progressive immigration organizations issued a similar plea to Pelosi and Senate Majority Leader Chuck Schumer, asking the congressional leaders to offer permanent protection and a path to citizenship to all undocumented essential workers and delivering this provision to the presidents desk for his signature.

Last year, House Democrats recognized the important contributions and sacrifices of undocumented essential workers by including in both versions of the Health and Economic Recovery Omnibus Emergency Solutions (HEROES) Act a provision offering temporary protection from deportation and work authorization to these individuals. The 117th Congress can and must do better, the letter stated.

Pelosis reluctance to include a path to citizenship for illegal immigrant essential workers, though, is not to be confused with a lack of eagerness to pass sweeping immigration reform. Since day one, the Biden administration, in conjunction with top congressional Democrats, has promised to reverse the Trump administrations actions and make it easier for undocumented migrants to take advantage of benefits reserved for U.S. citizens.

In addition to the new presidentssix executive orders concerning Deferred Action for Childhood Arrivals, the addition of illegal immigrants in U.S. Census totals, immediate cessation of construction on the southern border wall, and the suggestion to replace the word alien with noncitizen in U.S. immigration laws, members in the blue chambers of Congress have begun to workshop legislation focused on carrying out Bidens goal to offer amnesty to approximately 11 million illegal immigrants.

Jordan Davidson is a staff writer at The Federalist. She graduated from Baylor University where she majored in political science and minored in journalism.

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Dems Tried To Use COVID Relief Bill To Pass Amnesty For Illegal Aliens - The Federalist

How The Pandemic Raised The Stakes For School Choice – The Federalist

On this episode of The Federalist Radio Hour, CEO-elect of the American Federation for Children Tommy Schultz joins Culture Editor Emily Jashinsky to discuss how teachers unions are hurting childrens academic and social development by pushing to keep schools closed and why their anti-scientific demands highlight the importance of school choice.

Its just devastating what this is doing. Parents are trying to manage this awful situation on top of their own tragedies and issues and going on with their own work, Schultz said. Its a terrible time, and much of it is being driven by the politics of our K-12 political bureaucracy and the unions who are only serving the interests of their members and not students.

Support for school choice, Schultz said, has grown since the beginning of the pandemic, as more and more public school families, especially those with lower-income parents are increasingly frustrated with how politicized their childrens learning has become.

This is clearly a result of the teachers unions,frankly, being the best advocates for school choice just by doing everything that theyre doing here, Schultz said. They are an entirely political beast that is only interested in serving themselves rather than actually putting our students first in this education discussion.

Read more of The Federalists coverage of school reopenings, teachers unions, and the Biden administrations stance on in-person learning here.

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How The Pandemic Raised The Stakes For School Choice - The Federalist

Why It’s Unconstitutional To Impeach Someone After He Leaves Office – The Federalist

On Jan. 22, the Wall Street Journal published Princeton University professor of politics Keith E. Whittingtons defense of the disqualification-from-future-office purpose of the Senate impeachment trial of Donald Trump scheduled to begin on Feb. 8. The day before, more than 100 legal scholars, including Federalist Society co-founder Steven Calabresi, released a statement making the same argument.

Whittingtonholds that for the Founders, a Senate trial merely to disqualify a former federal official was a traditionally understood principle imported to America from England. Likewise, thescholars argue that history, including English impeachment history as well as the intentions of the Framers of the Constitution, is the source of the alleged constitutional power to convict prior officeholders as well as current ones. What is more, a Constitution without an independent disqualification power would be a Constitution that could be easily undermined.

In support of their scholarship, neither the scholars nor the professor cites nor quotes the Federalist Papers. Yet the history and meaning of the American Constitution begins with and is dependent on those papers which, like the Constitution itself, are unique in all of human and political history. Impeachment is dealt with in eight of the 85 papers (numbers 39, 65, 66, 69, 77, 79, 81, 84). Nowhere in any of the Federalist Papers is there a discussion of or attempt to separate between the two impeachment punishments of removal and disqualification.

In Federalist No. 65, whose subject is the suitability of the Senate as the court of impeachment, disqualification is not separately considered. The subject of Federalist No. 66 is the argument that the impeachment provisions dangerously combine both legislative and judicial authority in the Congress.

Hamilton, the author, answers by pointing to the constitutional requirement that the House and Senate act separately and independently in the impeachment process. When Hamilton contends impeachment is properly assigned to the Congress, rather than the Supreme Court, disqualification is not mentioned at all. In neither paper is there a discussion distinguishing between removal from office and disqualification.

In Federalist No. 39, Madison says that the President of the United States is impeachable at any time during his continuance in office.In Federalist No. 66, Hamilton explains that the fundamental purpose of impeachment is to protect the Congress against encroachments of the executive. Obviously, there can be no such encroachments by a former executive.

It is inconceivable that the Federalist authors who were, of course, subject to the criticisms of and corrections by their fellow Founders would have left such a major constitutional power, the stand-alone power of disqualification, uncommented on. Both the assumption and the plain text of the Constitution and the Federalist Papers is that the two punishments, removal and disqualification, go together.

For Democrats intent on keeping their fierce pursuit of Trump in the public eye, the Constitution establishes more powerful means than simple removal and disqualification. Article I, 3 states that impeachment shall not extend further than than removal and disqualification, but the party convicted shall nevertheless be liable and subject to Indictment, Trial, Judgment, and Punishment, according to law. And he need not be convicted under impeachment.

In specifically discussing the presidency in Federalist No. 65 and Federalist No. 69, Hamilton points out that a former president would afterwards that is, after he is no longer president be liable to prosecution and punishment in the ordinary course of law. Hamilton highlights this dramatic difference from English law concerning the person of the king, who is forever exempt from impeachment and prosecution.

During his term in office, a president may not be prosecuted in an outside court, only charged/impeached by the House and convicted by the Senate of High Crimes and Misdemeanors. Now that he is out of office, however, and for the rest of his life, Trump may be criminally indicted in any state or federal court for anything he ever did both during and outside his presidency.

InNixon v. Fitzgerald, the Supreme Court ruled that a president is forever immune fromcivilliability for his official acts while in office. Not so, however, for non-official civil acts. InClinton v. Jones, the Supreme Court held that a sitting president may be sued for his private, non-official pre-presidency conduct. Furthermore, in the 2020 decision of Trump v. Vance, the Supreme Court ruled that Trumps tax records could be subpoenaed by New York state prosecutor Cyrus Vance Jr. while he was still in office.

Both the scholars and the professor mention that a perfidious president or other officials could commit heinous acts against the country and the government and then avoid all consequences by resigning before an impeachment trial. As already pointed out and proven by the text of the Constitution and Hamiltons discussion of it, this contention is simply false.

Such a terminally criminal former president would continue to be liable to criminal prosecution for his in-office, terminally criminal acts. What is more, it is more than obvious that American popular and political opinion would never endure an attempt by such a person to regain public office. Finally, it is also refuted by American history insofar as no public figure has ever thought to commit such acts.

The scholars and Whittington bring up the impeachment and disqualification of resigned and no-longer-in-office Secretary of War William Belknap in 1876, who was acquitted in the Senate. But historical accounts are readily available with which to conclude that a significant number of those voting for acquittal had already decided that there was no impeachment jurisdiction over a former official. Also, of course, Belknap was an appointed official rather than an elected one, much less the president.

In a separatearticle in The New York Times, Calabresi along with Norman Eisen, one of the Democratss House 2020 impeachment counsels, have cited no authority for their unique claim that after the two-thirds impeachment vote, a disqualification vote only requires a simple majority vote in the Senate. Anyone is entitled to his or her opinion about the meaning of constitutional texts, of course. Scholarship, however, requires something more.

Since retiring as an Assistant U.S. Attorney, Thomas R. Ascik has written about legal and constitutional issues on a variety of websites including The Federalist, The Imaginative Conservative, and Law & Liberty.

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Why It's Unconstitutional To Impeach Someone After He Leaves Office - The Federalist

Liz Cheney’s GOP Civil War Is Here, And She’s Losing – The Federalist

On this episode of The Federalist Radio Hour, Federalist Western Correspondent Tristan Justice joins Culture Editor Emily Jashinsky to discuss his dispatch from Rep. Matt Gaetzs anti-Liz Cheney rally and what it means for the future of the GOP.

He really branded Liz Cheney as emblematic of the old way of doing things and what the Republican Party had gotten away from under Donald Trump, and what the Republican Party needs to stay away from if theyre going to be successful in the future, and the crowd loved it, Justice said. Every single person I spoke to in the crowd, they complained about Liz Cheney, not necessarily because of her impeachment vote. A lot of them said that impeachment was just the last straw, they were already upset with Cheney. They really just attacked her for being a symbol of the past.

Cheneys battle, Justice said, is not an isolated one and signals the coming of more GOP splits after years of growing distrust in D.C. elites and politicians.

Liz Cheney is in trouble in her own state. Trumpism has gripped the party, and I dont think theres a lot of space for the Republican Party to go back to the old way of doing things, Justice concluded.

Read more of Justices work here.

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Troll Replaced ‘Trump’ With ‘Cuomo’ In Maxine Waters’ Call To Violence And Dems Lost It – The Federalist

Blue checkmarks and Democrats took to Twitter on Thursday to condemn a call for violence against Gov. Andrew Cuomo and the people in his administration.The quote in question, however, was actually a call to violence against former President Donald Trump and his supporters from U.S. Rep. Maxine Waters, D-Calif., that a Twitter troll account called Cuomo Watch satirically modified to say Cuomo.

If you see anybody from the Cuomo Administration in a restaurant, in a department store, at a gasoline station, you get out and you create a crowd. And you push back on them. And you tell them theyre not welcome anymore, anywhere. -Maxine CuomoWatch, the tweet reads.

Soon after the tweet was shared, prominent New York politicians, blue checkmarks, and Democrats in other states took to Twitter to condemn the call to action.

This is appalling and dangerous. Encouraging violence must never be tolerated. Shame on whoever is behind this kind of garbage, the speaker of the New York State Assembly wrote.

This is beyond outrageous, a state senator added in her retweet. Two weeks ago we saw what happened when arsonists throw gas around. Twitter should ban this dude now!

This is dangerous, reprehensible and has no place in any public discussion. Oh, and spare me the someone else did it too excuse. Someone else saying a variation of this doesnt change the fact that this is seeking to incite violence against a public official and their staff, another assemblyman shared.

@CuomoWatch We will not tolerate threats against public officials by radical extremists in this city or state. There is no room for violence or targeting against anyone, especially public servants. Not after what happened in D.C. I will be alerting appropriate authorities, the borough president of Manhattan tweeted.

U.S. Rep. Ritchie Torres, D-N.Y., even spoke out, saying he was appalled by the call to action after living through the insurrection against the US Congress.

We must all denounce in no uncertain terms any attempt at inciting political violence, he shared in a now-deleted tweet.

Cuomos senior adviser Rich Azzopardi also spread the misinformation, retweeting peoples condemnations and even accusing Rep. Elise Stefanik, R-N.Y., and her staff, without presenting evidence, of condoning violence against the governor.

When confronted about the legitimacy of the tweet and the true source of the quote, the legislators either deleted their tweets or attempted to defend their double-standard on political violence.

I see what they did, wrote state Sen. Diane Savino, but that was then and this is now, and 4 years of Trump has led to words becoming weapons. We cant just ignore them anymore, people take them as a call to violent actions.

Cuomos office did not respond to The Federalists request for clarification on whether they still condemn the comments now that they know who originally made them. Instead, in his press conference on Friday, Cuomo blamed the internet and the troll who created the post.

When you see the ugliness being fomented for selfish political reasons, everyone should condemn it. We all know who spreads the ugliness on the Internet, Cuomo says.

Many Democrats have a history of calling for violence against Trump and his supporters including Cuomo, who recently said that he wouldve decked Trump if he werent a governor.

The outrage over the modified quote also follows a report from the New York attorney generals office that found that Cuomo and his administration lied about the number of COVID-19 deaths in nursing homes following his policy that sent infected patients into care facilities during the pandemic.

Jordan Davidson is a staff writer at The Federalist. She graduated from Baylor University where she majored in political science and minored in journalism.

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Troll Replaced 'Trump' With 'Cuomo' In Maxine Waters' Call To Violence And Dems Lost It - The Federalist

Why Trump Should Press His Case On Voter Fraud – The Federalist

With a major shakeup in Donald Trumps legal team this weekend, increasing attention is being paid to what defense the former president will mount in his upcoming Senate impeachment trial.

Conventional wisdom is that Republican senators would prefer Trump simply argue that it is unconstitutional to impeach a former president. Reportedly, they do not want him to argue he was not guilty of inciting a riot, and most certainly do not want him to argue that there was, in fact, widespread election fraud.

One can understand why these senators would rather rule only on the narrow issue of the constitutionality. It is far less contentious than the other two arguments, and why even bother with them if the first argument makes them moot?

But for Trump, who has already lost his largest platform on Twitter, the ability to lay out the case on why he didnt incite a riot and that there was widespread fraud may seem irresistible. It would be far riskier, but there is still a very good chance he would be acquitted, maybe by a closer margin possibly with some annoyed votes in his favor, but acquitted nonetheless.

On all three counts, Trump has very reasonable arguments to make. And given that so many in the media have already made up their mind that he is obviously guilty, he would have a very low bar to cast doubt on that guilt. So lets look at each defense on its own.

The constitutional question of whether you can convict a former president in the Senate appears to be a legal 50-50 ball. There are experts on each side of the question. Both make reasonable if contradictory arguments, and neither can really claim certainty. This makes it an easy out for Republican senators, and its why they dont want to look any further.

As far as the question of incitement, Ive made a longer argument in these pages, but it boils down to the idea that Trumps actions were way too broad and indirect to be considered an incitement. Now, those in favor of conviction point out that the legal standard, which almost everyone agrees Trump did not meet, doesnt matter here. Thats true. The Senate can define it anyway they want, but they still need a standard by which to do so, and more importantly they will setting that standard in an official capacity.

If Trumps speech was incitement to riot, then what is the limiting principle? Was Rep. Maxine Waters inciting people when she told them to get into Trump officials faces in 2018, all while she was pushing the big lie of Russian collusion?

American political discourse is replete with fighting metaphors and lying. We also now know that the rioting had started a mile away from Trumps speech before he finished speaking and that elements were pre-planned. The case for incitement is far weaker than the media would have you believe.

Finally comes the most controversial potential defense: that there really was massive voter fraud. To many this seems like a Kamikaze defense, but it might not be. Republican officials have been pressured since the riots to say that there was no widespread voter fraud. The idea seems to be that if they refuse they are also complicit. Its absurd, of course, as this past election was one of the sloppiest in recent memory. That happens when you change the rules on the fly.

There are plenty of important irregularities in the election that really do need investigation. That is why Sen. Josh Hawley and Sen. Ted Cruz launched a symbolic effort to refuse certification in order to shine a spotlight on these irregularities. The problems were real. They exist. Are they enough to overturn the results? It appears not, but that really isnt the point, the point is we need to fix them anyway.

Too many Republicans are being shamed now into not making a very important argument about election security. It would be the most Trump thing in the world to show up at the Senate and fight the fight they refuse to. And again, Trumps bar would be low. We have been assured there was no fraud, no major problems in mail-in voting. Just a handful of examples would put the lie to that.

Trump seems poised to get a win when the votes are cast in his trial. The question is how big the win will be. I dont think you answer that question based on how many votes he gets. I think you answer it based on how broad the scope of his acquittal is. Trump doesnt want to win on a technicality; he wants to win on the merits. A fighter doesnt hide behind constitutional controversy, he says, You tried me. I won.

There is every reason Trump should press all three arguments. Together they represent his best possible case, a three-pronged attack on every element of the charges against him. Even he wins with a smaller margin, by fighting the whole thing and winning, he will emerge much stronger than choosing otherwise.

David Marcus is the Federalist's New York Correspondent. Follow him on Twitter, @BlueBoxDave.

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The Biden Administration Just Made Peter Strzok’s Wife A Top SEC Official – The Federalist

President Joe Bidens Securities and Exchange Commission (SEC) announced it hired Melissa Hodgman to lead the agency as its acting director of the Division of Enforcement last week.

Melissas dedication to investor protection, broad experience in the Division, and proven track record of collaboration and creative problem solving make her ideally suited to this role, SEC Acting Chair Allison Herren Lee celebrated in a statement. As Associate Director, Melissa has overseen a wide range of complex and programmatically important matters, and has been a leading voice in the Division on critical issues of diversity, hiring, and labor-management relations.

Hodgman, according to the agency press release, has been with the SEC since 2008 as a longtime bureaucrat engaging in a wide range of litigation. Hodgman is also married to another, better-known longtime Washington bureaucrat, Peter Strzok, made famous for his role in the FBIs deep-state Crossfire Hurricane operation, which featured a witch hunt investigation that sought to incriminate President Donald Trump.

Before being fired from the FBI, Strzok rose to prominence when it was revealed that Strzok had conspired with an FBI colleague-turned-mistress over the course of the investigation, as they tried to oust the elected president. Text messages that emerged in the summer of 2018 from an Office of Inspector Generals report revealed the two began conspiring the summer before Trump even won the November election. Page resigned from the FBI, only to later be hired by MSNBC, while Special Counsel Robert Mueller removed Strzok from the Russia investigation.

The pair had since become widely mocked by the president when railing against the Russia hoax and became the subject of the theatrical play FBI Lovebirds: UnderCovers, which was performed at the Conservative Political Action Conference last year.

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Millennials Meet Mortality With The Death Of Dustin Diamond – The Federalist

Actor Dustin Diamond passed away this week at the age of 44, just weeks after being diagnosed with stage four lung cancer. Diamond was best known for his role as Screech Powers on Saved by the Bell, a character he portrayed for 13 years.

Diamond died just three weeks after his initial diagnosis of stage IV lung cancer, according to his publicist. As tragic as any death is, particularly at such a young age, articles dedicated to his memory and in honor of his body of work may be few and far between. A look at Diamonds career, shaped by a single role on a teen TV show that aired more than 30 years ago, would not be an obvious inspiration for entertainment writers.

But Screech Powers was not just a forgotten TV side character; he was a cultural touchstone for almost everyone born in the late 70s and early 80s. Ever youthful, nave, and optimistic for whatever the world may have for him, Screech represented the spirit of 90s kids. He got pushed around, he got teased. But his tenacity and love for life always kept him in the winners circle.

Saved by the Bell, however one may feel about the overall quality of the show, was definitive programming for my age group. We all dreamed of being beautiful like Kelly, or effortlessly cool like Zach. It was one of the first shows specifically aimed at young teens and its success was achieved by striking a perfect balance between kid-dom early adulthood themes.

Screech was the foil of the show who was seldom the center of a story but was required to make other characters look either good or bad, depending on how they treated him. He represented all of our little brothers and sisters: an annoying drag, but the person we loved the most in the world. And it was those character traits and Diamonds goofy, hopeful grin that kept him on the show, in every iteration, far longer than any other character.

Diamonds curly brown hair, wide toothy grin, and child-like wonder remained with him throughout his run on the show. His youthfulness was not by accident, he was several years younger than any of the other cast members, more likely to be the age of the kids watching the show.

Like Screech, we watched the show and admired the older, more adult characters. Co-star Mario Lopez referred to Diamond as a fun, goofy little brother. We wanted to emulate them, to impress them, to be accepted by them. But perhaps it was Screech we were relating to. We were the wide-eyed pre-teens ready for new experiences and Screechs willingness to embarrass himself in search of answers and friendship was admirable.

Many of us grew out of Saved by the Bell before the final version of the show, The New Class, went off the air in 2000, 12 years after first meeting Screech. Diamond remained in the role from age 11 to 23, returning post-college years to portray an assistant at the high school.

After the end of Screech, Diamond infrequently worked as an actor, finding himself in the news for less savory reasons. Like many child actors before him, Diamond slid in and out of obscurity, reaching for a comeback through professional wrestling, publishing a tell-all book, and even releasing a sex tape.

He spent time in jail after a violent bar altercation. Rumors of drug addiction and depression swirled, and Diamonds career was further pocked after being snubbed from a Saved by the Bell reboot that began airing last year. Diamond was supposedly in discussions about joining the reboot in its second season when his illness was revealed in early January. And, in just a matter of weeks, he was gone.

His passing is a watershed moment for millennials, who are now forced to accept the fact that we are not in our immortal youth any longer. Death came for one of us just as we prepare for middle age. Every generation meets a moment when they realize they are mortals, that they cant outrun death, and that eventually, they run out of chances.

Its now time for acceptance that, never again, will we be able to watch a Saved by the Bell rerun without a sense of sadness and loss not only for Diamond, but for our own youths. And as time marches on, none of our nostalgic culture will remain untouched.

For millennials, our moment of mortality has arrived.

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Millennials Meet Mortality With The Death Of Dustin Diamond - The Federalist

On ‘WandaVision,’ We Begin to Get Some Answers – The Federalist

(warning: spoilers ahead)

The big question so far on WandaVision has been, What exactly are we watching? Well, in episode four, we began to get some answers. Granted, it is a Marvel show so we also got more questions, but we did get some answers too, along with the appearance of two Marvel Cinematic Universe sidekicks, and a better idea of what S.W.O.R.D. is.

Todays WandaVision, amusingly titled, We Interrupt This Program, gives us some of the backstory on what exactly is going on. The episode begins with a chaotic scene. In a hospital room, we see Monica Rambeau re-materialize after The Avengers bring her back from The Blip, the MCUs name for the 50 percent of living beings that disappeared with the snap of Thanoss fingers in Infinity War.

She runs around in a panic looking for her mother who was apparently about to be discharged from cancer treatment. After finding a doctor who recognizes her, Monica is informed that her mother died three years ago when the cancer came back, which was two years after Monica up and vanished along with half of the universe.

This is the first time weve seen the immediate aftermath of the heroic sacrifices The Avengers made at the end of the Infinity Saga. Now we see just how traumatizing it must have been for people to vanish from existence for five years only to return to a world they didnt necessarily recognize.

After Monica leaves the hospital, she makes her way back to the headquarters of S.W.O.R.D., where she works, only to find her key card doesnt function anymore. She encounters the director of the organization, a role that used to be held by her mother. He sends her on a mission to aid the FBI in a missing persons case in rural New Jersey.

At this point, Monica finds agent Jimmy Woo, played by Randall Park, who we last saw in Ant-Man and the Wasp as the FBI guy in charge of keeping an eye on Ant-Man. Woo is now trying to track down a source he had in witness protection who was hidden in Westview, New Jersey. Monica learns that no one in the town seems to be reachable, and the sheriff, who is stationed outside the towns city limits sign, denies the town even exists.

Monica and Woo send a S.W.O.R.D. drone into the town only to watch it disappear. Monica then walks up to the towns border and sees an energy field that looks a lot like an old-fashioned television screen did if you got too close. She touches it and gets sucked into the town.

Twenty-four hours later we see the next MCU sidekick join the party, Darcy Lewis, played by Kat Dennings. The last time we saw Darcy was in the first two Thor movies. Here shes being called in by S.W.O.R.D. to investigate the town. Upon examining it, she finds that the town is broadcasting an old television signal.

Darcy proceeds to have the government goons set up an old TV so she can see the broadcast a broadcast that happens to be what weve been watching through the first three episodes of WandaVision, and we learn that its Darcy whom we saw at the end of some of these episodes watching them with us on an old television set.

We then see Woo, Darcy, and the S.W.O.R.D. team investigate the anomaly and try to figure out whats going on. They begin to identify the people cast in Wandas delusion, and it turns out many of them are just normal citizens who somehow got dragged into this sitcom fantasy. Darcy also asks the question weve all been wondering about Vision since the first minute this show started, Isnt he dead?

In an earlier episode, we heard what sounded like Woo trying to talk to Wanda through the radio. Now in this episode, we get to see how that moment came about. Darcy and Woo cobble together a plan to try and talk to Wanda through the radios they can see on screen. They also send a man dressed in a biohazard suit through the sewer to try to reach Monica. Hes the one who appeared as a random beekeeper in the first episode. Thats what her delusion changed him into.

We also get to see the rest of the scene from the last episode where Wanda figured out that Monica was not who she appeared to be and ejected her from the town. It turns out she did that quite violently by sending Monica through the walls of her house, the fence in her yard, and flying through the air at breakneck speed. The thing is, the S.W.O.R.D. observers dont see that scene; they just see Monica disappear as we did in the previous episode. That leads Darcy to posit that someone is censoring the broadcast from them and not letting everyone see what is happening.

Then were left with the most disturbing of images as we approach the end of this episode. Wanda, slightly shaken from her delusion by Monicas mention of Ultron, but not entirely, sees Vision enter their home. Instead of the Vision weve seen who is miraculously alive, well, and remarkably human, we see the dead Vision we last saw in the fields of Wakanda after Thanos ripped an Infinity Stone straight from the sythezoids head. Hes still talking to her, but hes clearly not alive, with vacant eyes, and a large hole in his head.

Its a jarring, unnerving, and very disturbing break from the happy-go-lucky sitcom world weve been immersed in through the first few episodes.

Then, its gone.

Wanda returns to her world where she and Vision are alive and well in a 1970s sitcom with two bouncing baby boys. Then we get perhaps the most interesting exchange between the title characters weve had yet. Vision, seeing the upset nature of Wanda, says, We dont have to stay here. We can go wherever we want.

Wanda, beginning to piece together what is going on, with tears in her eyes, says, No we cant. This is our home. Vision says, Are you sure? and Wanda answers, Dont worry darling, I have everything under control.

Then we cut to Monica, who is on the grass outside Westview, exactly where we left her at the end of the last episode. She is surrounded by government agents. Darcy and Woo run up to Monica, who is still dazed on the ground, and ask if shes okay. Monica says, Its Wanda. Its all Wanda. The episode closes with Wanda and Vision cradling their babies while watching TV on their couch as Jimmy Hendrix sings Voodoo Child.

My working theory has been that Mephisto is the villain behind all this nonsense weve been seeing in WandaVision and that he would be the central villain of the next few Marvel movies, but the way this episode ends raises interesting questions.

Will Wanda herself move from being a hero, a member of The Avengers who saved the universe from the evils of Thanos, to a villain herself? Could her immense grief at the loss of her lover, Vision, drive her to become a crazed supervillain?

Could Wanda be the next big baddy of the MCU? Maybe well find out more next week on WandaVision.

Brad Jackson is a writer and radio personality whose work has appeared at ABC, CBS, Fox News, and multiple radio programs. He was the longtime host and producer of Coffee & Markets, an award-winning podcast and radio show with more than 1,500 episodes. Brad covers all things edible and cultural for The Federalist. You can find him on Twitter and Instagram at @bradwjackson.

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Outside the Wire director explains how Anthony Mackie was turned into a cyborg – CNET

Pilou Asbk as Victor Koval (left) and Anthony Mackie as Capt. Leo in the Netflix film Outside the Wire.

Over his career, the Swedish filmmaker Mikael Hfstrm has worked with some of Hollywood's biggest stars, like Arnold Schwarzenegger, Sylvester Stallone, Jennifer Aniston, John Cusack and Anthony Hopkins. It's hard to imagine that he got his start as a writer for Swedish television shows. In 2004, his film Evil received an Academy Award nomination for Best Foreign Language Film, and that's when he went from directing films in Sweden to helming movies in Hollywood.

Hfstrm's newest film is Outside the Wire, on Netflix. It stars Anthony Mackie as a top secret android army officer who recruits a drone pilot, played by Damson Idris, to stop a nuclear attack. The sci-fi thriller delves into philosophical questions about humans and morality. The relationship between Mackie and Idris echoes the relationship Denzel Washington's and Ethan Hawke's characters had in the film Training Day.

Subscribe to CNET Now for the day's most interesting reviews, news stories and videos.

On CNET's I'm So Obsessed podcast, Hfstrm explains the challenge of finding the perfect look on screen for Mackie's cyborg character, Captain Leo.

"He is a bio technical prototype. He looks like you and me," said Hfstrm. "One of the biggest jobs, obviously, was to try to figure out exactly what he looked like. What his interior looked like. I don't know how many versions we went through to find something that didn't feel overdone, but was also visually interesting. And hopefully it's something that we haven't seen in other movies."

During our conversation, we discussed the parallels between the way nuclear weapons are shown in popular culture and the way they are secretly present in all of our lives. Hfstrm also shares what it was like working with both Schwarzenegger and Stallone in the film Escape Plan.

"It was a good thing that they were both in the movie, because they were sort of competing at being the nicest guy on set," said Hfstrm with a laugh. "They were older, and their rivalry had passed. And now they were old friends sitting on set smoking cigars, telling war stories and it was just a good time."

You can listen to my entire conversation with Hfstrm on Spotify or Apple Podcasts. You can watch Outside the Wire on Netflix. Also, you can subscribe to I'm So Obsessed on your favorite podcast app. In each episode, Connie Guglielmo or I catch up with an artist, actor or creator to learn about work, career and current obsessions.

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NewsBytes Briefing: Musk’s army of gamer cyborg monkeys, and more | NewsBytes – NewsBytes

There is never a dull moment with Elon Musk. At a recent Clubhouse interaction, the world's richest man revealed that his Neuralink start-up has monkeys with brain implants that allow them to play video games with one another.

Subsequently, his tweet revealed the long-term plans of the start-up: Human-AI symbiosis that is touted as species-level important.

Read on for more craziness that transpired today.

If there was ever a case against brain implants, WhatsApp's latest attempt to brainwash its users into conceding to its privacy policy trap makes a good one.

The messaging service has been sending story-like in-app messages reminding users that Facebook isn't an evil corporation that harvests and sells their private data to achieve everything ranging from manipulating your mood to manipulating elections.

Even as Big Tech has managed to de-platform who was once the most powerful person in the world and kill off competitors with zero consequences, the upside-down land of Australia isn't having any of it.

Australian premier Scott Morrison called out Google's bluff to pull its search engine from the country. Now, Microsoft has offered to fill the void with its Bing search engine.

Australia isn't the only one sticking it to the powers that be.

Reddit's WallStreetBets saga is an unprecedented case of how the internet facilitated people's burning desire to wrest the levers of economic power away from the clutches of a few chosen elites.

This silent revolution didn't involve peasants with pitchforks, but the working class weaponizing their stimulus checks to break Wall Street's back.

Now back to more boring stuff.

If you have bought the new M1-powered MacBooks this Christmas, you are in for a treat with NVIDIA bringing native M1 support to its GeForce NOW cloud gaming service.

What's more, Apple's next M1 chips are rumored to include a 128-core GPU. It looks like proper gaming on the Mac might be an actual possibility in the future.

Don't you hate it when tech companies take a break from subverting democracy and sowing seeds of civil war to come up with products squarely targeted at the sort of people who answer Nigerian email scams?

Well, Xiaomi's latest patent seems to be an attempt to top yesterday's snake oil campaign featuring an improbable wireless charging system that was thoroughly debunked by EEVBlog.

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Cris Cyborg Scared To Face Kayla Harrison Inside The Cage – The MIX

According to a source close to FightLine, reigning Bellator champion Cris Cyborg is scared of a potential showdown with Kayla HarrisonPFL Champion Kayla Harrison Returns To Action Once More.

At the end of 2020, Harrison stepped into the Invicta FC cage and moved up in weight to find a new challenge. Her readiness at any moment to compete continued before another planned fight was scrapped.

The reigning Professional Fighters League lightweight champion and Olympic gold medalist will return to the PFL cage in early 2021 when the new season begins.

However, she remained interested in a potential mega-bout with Cyborg if things could be worked out.

The source has indicated that Cyborg prefers to remain strictly in Bellator MMA and continue her dominance there instead of testing herself against Harrison.

Harrison has been willing to move from lightweight to featherweight to make things happen for herself in continued the climb to being the top female fighter the sport has to offer.

She is 8-0 including a recent finish of Courtney King. Harrison has won all seven of her fights under the PFL banner including a 2019 decision vs. Larissa Pacheco in the tournament final.

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Prior to embarking on her career in MMA, Harrison compiled a record of 45-7 in judo including gold at the 2016 Summer Olympic Games and 2012 Summer Olympic Games.

PFL officials allowed Harrison to step into the Invicta FC cage in November and were willing to do the same for a December match in Titan FC.

Cyborg signed with Bellator and made her promotional debut in 2020 with a finish of Julia Budd to win the featherweight title. She defended it last October over Arlene Blencowe.

Along with winning gold in Bellator, the Brazilian is also a former UFC and Strikeforce champion, sporting a career record of 23-2 overall with 18 wins by knockout.

Any showdown between Harrison and Cyborg now appears off the table as both move forward with their respective careers. We will continue to monitor and follow this situation on TheMix.

Continue reading here:

Cris Cyborg Scared To Face Kayla Harrison Inside The Cage - The MIX