LSD Lets The Brain ‘Free Itself’ From Divisions Dictated by Anatomy, Scientists Find – ScienceAlert

Where does the mind 'meet' the brain? While there's no shortage of research into the effects of psychedelics, drugs like LSD still have much to teach us about the way the brain operates and can shine a light on the mysterious interface between consciousness and neural physiology, research suggests.

In a new study investigating the effects of LSD on volunteers, scientists found that the psychedelic enables the brain to function in a way beyond what anatomy usually dictates, by altering states of dynamic integration and segregation in the human brain.

"The psychedelic compound LSD induces a profoundly altered state of consciousness," explains first author and neuroscience researcher Andrea Luppi from the University of Cambridge.

"Combining pharmacological interventions with non-invasive brain imaging techniques such as functional MRI (fMRI) can provide insight into normal and abnormal brain function."

The new research falls within the study of dynamic functional connectivity the theory that brain phenomena demonstrate states of functional connectivity that change over time, much in the same way that our stream of consciousness is dynamic and always flowing.

As this happens, and the human brain processes information, it has to integrate that information into an amalgamated form of understanding but at the same time segregate information as well, keeping distinct sensory streams separate from one another, so that they can be handled by particular neural systems.

This distinction the dynamics of brain integration and segregation is something that gets affected by psychedelic drugs, and with the advent of brain imaging technology, we can observe what happens when our regular functional connectivity gets disrupted.

In the study, a group of 20 healthy volunteers underwent brain scans in two separate sessions, a fortnight apart. In one of the sessions, the participants took a placebo before entering the fMRI scanner, while in the other slot, they were given an active dose of LSD.

In comparing the results from the two sessions, the researchers found that LSD untethers functional connectivity from the constraints of structural connectivity, while simultaneously altering the way that the brain handles the balancing act between integration and segregation of information.

"Our main finding is that the effects of LSD on brain function and subjective experience are not uniform in time," Luppi says.

"In particular, the well-known feeling of 'ego dissolution' induced by LSD correlates with reorganisation of brain networks during a state of high global integration."

In effect, the drug's state of altered consciousness could be seen as an abnormal increase in the functional complexity of the brain with the data showing moments where the brain revealed predominantly segregated patterns of functional connectivity.

In other words, the 'ego dissolution' of a psychedelic trip might be the subjective experience of your brain cranking up its segregation dynamics, decoupling the brain's structure from its functioning meaning your capacity to integrate and amalgamate separate streams of information into a unified whole becomes diminished.

"Thus, LSD appears to induce especially complex patterns of functional connectivity (FC) by inducing additional decoupling of FC from the underlying structural connectome, precisely during those times when structural-functional coupling is already at its lowest," the authors explain in their paper.

"Due to the effects of LSD, the brain is free to explore a variety of functional connectivity patterns that go beyond those dictated by anatomy presumably resulting in the unusual beliefs and experiences reported during the psychedelic state."

The findings are reported in NeuroImage.

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LSD Lets The Brain 'Free Itself' From Divisions Dictated by Anatomy, Scientists Find - ScienceAlert

Why Did Ellen Pompeo Almost Pass On ‘Grey’s Anatomy’? | TheThings – TheThings

During the time when the casting of Greys Anatomy was taking place, the performer wound up having another offer on the table.

Making a career on the small screen is doable, but not after a performer has gone through the mud to even get an opportunity for something decent. Acting is a tough business, but shows likeThe Office andFriends have taken relative unknowns and have turned them into stars. Because of this, most performers out there will do just about anything to secure a spot on an upcoming pilot.

Ellen Pompeo is a massive star these days thanks to starring onGreys Anatomybut had things gone another way, she wouldnt have even appeared on the show in the first place, forever altering the history of television.

Lets look back and see why Ellen Pompeo nearly passed onGreys Anatomy.

At this point in her career, it is almost impossible to imagine Ellen Pompeo playing another character other than Meredith Grey on the small screen, but there was once a point in time when she was doing anything and everything possible to land a role on a television series. During the time when the casting ofGreys Anatomy was taking place, the performer wound up having another offer on the table.

Landing one role is hard enough, but sometimes, a performer will have to confront the difficult decision of choosing between roles. Choose the right role, and youll be working for a decade while rolling in millions. Choose the wrong role, and your show will be quickly off the air and youll be right back to square one. Such is the life for a performer even lucky enough to be in this predicament.

According toCheatSheet, there was once a point in time when the actress was attached to a show calledSecret Service, which would have been drastically different fromGreys Anatomy. When speaking with TV Guide, Pompeo would reveal, I was offered the role of Meredith. I had done a movie for the studio called Moonlight Mile, so the studio was aware of me. Then I met Bob Orci and Alex Kurtzman We sat down and talked about me possibly doing an arc on Alias.

Pompeo would continue, saying, That didnt happen. Bob and Alex wrote a show called Secret Service. I really wanted to do that and the studio really wanted me to do Greys [Anatomy] instead. I wanted to do the Secret Service pilot that didnt go, of course; me and my brilliant choices.

Related:What Happened To Katherine Heigls Acting Career After She Left Greys Anatomy?

Now that she had confronted the decision of choosing between two roles and had picked the wrong one, it is interesting to think what would have happened hadSecret Service actually taken off and who would have ultimately become Meredith Grey. Eventually, after things fell apart from the show she initially wanted to do, Pompeo would meet with Shonda Rhimes and figure out the right move in an instant.

She would tellTV Guide, I read Grey's and I went and met Shonda and I decided to come on and do this. It was just an invitation and I happily accepted."

And just like that, television history was made. Of course, there is simply no way of knowing what a television show will become in the early stages, but clearly, people behind the scenes saw the potential thatGreys Anatomy had. Even though ABC was swinging and missing on plenty of shows during that era, they were sitting on a gold mine withGreys.

Since the show debuted, it has been nothing short of one of the most remarkable achievements on the small screen. It has been on the air since 2005 and it has aired over 300 episodes, which is a feat accomplished by few programs in history. Pompeo has been laughing all the way to the bank ever since.

Related:Will Season 18 Of Greys Anatomy Happen?

DespiteGreys being the success that it is, the longer that it has gone on, the more people have wondered about how much longer the show has on the air.

While the show has done wonders for the performer, Pompeo has acknowledged that she wont be staying on the show forever and will eventually call it a day sooner rather than later, which is totally understandable.

When speaking withEntertainment Tonight, the performer would touch on this subject, saying, But certainly I think to dip out sooner rather than later, at this point, having done what we've done, to leave when the show is still on top, is definitely a goal. I'm not trying to stay on the show forever. No way. The truth is, if I get too aggravated and I'm no longer grateful there, I should not be there."

Related:Katherine Heigl Branded Bitter After She Slams Justin Chambers Exit From Greys

Secret Service was the show that almost robbed the world of theGreysthey know and love, but thankfully, things worked out for the better in the end.

Next:Which Original Greys Anatomy Star Has The Highest Net Worth?

Is Robert Downey Jr.'s Son, Indio Falconer Following In His Dad's Footsteps?

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Why Did Ellen Pompeo Almost Pass On 'Grey's Anatomy'? | TheThings - TheThings

Katherine Heigl Looks Back on Leaving Grey’s Anatomy : ‘I Could Have Handled It with More Grace’ – Yahoo Entertainment

James Marsden Defends 27 Dresses Costar Katherine Heigl as She Reflects on Being Labelled 'Difficult'

PLUS: Katherine Heigl Reveals Mental Toll of Being Labelled 'Difficult' and If She Would Appear on Grey's Anatomy Again

Katherine Heigl isn't looking to rewrite the past.

After three decades in front of the camera, the Firefly Lane star knows she's made some mistakes, but she can find the value in even her worst blunders. "I don't think you get through life without any regrets," she tells PEOPLE in this week's issue. "But you can create some purpose from it."

The actress, 42, began her career as a child model. Teen stardom followed, but it wasn't until the 2005 premiere of Grey's Anatomy that she became a household name. And with that came added stress, fear and scrutiny.

Sundholm Magnus/Action Press/Shutterstock

The year after her 2007 Emmy win for her role as Dr. Izzie Stevens, Heigl withdrew her name from contention for a repeat, saying she "did not feel that I was given the material this season to warrant" a nomination. That incident, compounded with several other comments and complaints Heigl had previously voiced, earned the star the dreaded label of "difficult."

"I know there's a better way to deal with those things than I did," she admits. "I could have handled it with more grace."

Richard Cartwright/Getty

RELATED: Katherine Heigl Opens Up About the 'Powerful' Bond She Has with Her 'Sacred Six' Friend Group

Heigl left Grey's Anatomy in 2010, at the peak of her diminished reputation, and spent some quality time in what was then her new home in Utah with her daughter Naleigh, now 12.

"I don't actually regret leaving Grey's Anatomy I did the right thing for me and for my family but I do regret the heightened drama I was feeling at that time," she says. "If I'd known anything about meditation then, or had been talking to a therapist or someone to help me through some of the fear that I was steeped in, I think I would have been more calm in how I approached what boundaries I needed to create to thrive."

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Heigl continues: "I certainly regret not learning earlier how to manage my anxiety better. Living at that heightened level of anxiety ... created a defensiveness in me and wariness and assuming that people were against me. I let my mind run rampant without the tools to properly manage that."

For more on Katherine Heigl, pick up the latest issue of PEOPLE, on newsstands Friday, or subscribe here.

Since then, she's been doing the work.

"The last five years has been really about learning how to manage that anxiety and to control my own thoughts," she says. "I learned that not managing stress leads to not dealing with negativity or frustration or disappointment in the proper way."

RELATED: James Marsden Defends 27 Dresses Costar Katherine Heigl as She Reflects on Being Labelled 'Difficult'

Scott Garfield/Walt Disney Television Katherine Heigl and Justin Chambers on Grey's Anatomy

But that wasn't all Heigl learned from her years on the hit Shonda Rhimes series.

"Something else that experience taught me is that no matter how big an opportunity or how rewarding something is, there will be moments of struggle," she says. "There will be difficulties and disappointment and miscommunications, but you must learn how to manage those with grace instead of fear."

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Still, Heigl has fond memories of her time at what was then known as Seattle Grace Hospital, and she says she'd "never say never" to returning.

"When I look back on Grey's Anatomy, so much of it was a really extraordinary experience," she says. "It feels like a dream sometimes, all of us in it together like that. I'm grateful for all of it and I'm so grateful that I grew up enough to allow it to teach me something."

Firefly Lane is streaming on Netflix now. Heigl's new thriller, Fear of Rain, is available on-demand beginning Feb. 12.

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Katherine Heigl Looks Back on Leaving Grey's Anatomy : 'I Could Have Handled It with More Grace' - Yahoo Entertainment

Katherine Heigl admits Grey’s Anatomy exit ‘could have been done with more grace’ – Metro.co.uk

Katherine has some regrets about how she left Greys Anatomy (Picture: Getty/NBC)

Katherine Heigl has spoken out about her Greys Anatomy exit and admitted that she could have handled it with more grace.

The actress played Izzie Stevens on the long-running medical drama, but left after six years in 2010 due to issues behind-the-scenes.

Her character ducked out halfway through season six never to return, and Katherine was later labelled difficult and unprofessional as a result of the fallout.

But after a decade away from the show, Katherine has had time to reflect and admits that while shes ultimately glad she quit, she could have handled the situation better.

Speaking to People magazine, she said: I dont actually regret leaving Greys Anatomy.

I did the right thing for me and for my family but I do regret the heightened drama I was feeling at that time.

Something else that experience taught me is that no matter how big an opportunity or how rewarding something is, there will be moments of struggle, she added.

There will be difficulties and disappointment and miscommunications, but you must learn how to manage those with grace instead of fear.

The upset behind-the-scenes started when Katherine famously removed her own name from the 2008 Emmys ballot for her performance on the show, stating she hadnt been given the material to warrant the nomination.

Shonda Rhimes, the creator of the show, later said in an interview with Oprah Winfrey: On some level it stung and on some level I was not surprised. When people show you who they are, believe them.

In 2014, Rhimes took another swipe while promoting new series Scandal, and told Hollywood Reporter: There are no Heigls in this situation, adding that there was a no a**hole policy on set.

Thankfully they now all seem to have buried the hatchet, and in 2019, Greys gave an update on Izzie, revealing she was living on a horse farm in Kansas.

While she never appeared on screen, her love interest Alex Karev (Justin Chambers) left the Seattle hospital in order to win her back, after discovering she had secretly mothered his twins.

Katherine is now leading the cast of new Netflix series, Firefly Lane, alongside Scrubs star Sarah Chalke.

Greys Anatomy is available on Amazon Prime Video in the UK.

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MORE : Will there be a second season of Firefly Lane? Netflix dramas cliffhanger ending explained

MORE : Katherine Heigl weighs in on Alex and Izzies Greys Anatomy reunion: Isnt that an a**hole move?

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Katherine Heigl admits Grey's Anatomy exit 'could have been done with more grace' - Metro.co.uk

Katherine Heigl recalls her controversial exit from Grey’s Anatomy – 9TheFIX

Katherine Heigl has reflected on her sudden exit from Grey's Anatomy.

The Firefly Lane actress, 42, admitted her departure could have been handled differently, but life is filled with momentary lapses in judgement.

"I don't think you get through life without any regrets," she told People of her time on the show. "But you can create some purpose from it."

READ MORE: What happened to Katherine Heigl?

In 2008, Katherine Heigl pulled out of the Emmys race for Grey's. At the time, she said she didn't deserve a nomination because the writing for her character wasn't good enough in Season 4.

"I did not feel that I was given the material this season to warrant an Emmy nomination and in an effort to maintain the integrity of the academy organisation, I withdrew my name from contention," she said in an official statement.

Heigl earned the unflattering title of being "difficult", and eventually left her role as Izzie Stevens in 2010.

"I know there's a better way to deal with those things than I did," she told the outlet. "I could have handled it with more grace."

READ MORE: Grey's Anatomy feud explainer: Katherine Heigl and Isaiah Washington

Heigl said that she didn't regret her decision to leave, but she did regret the "heightened drama" that unfolded upon her exit. The actress has subsequently learned how to prioritise self-care.

"If I'd known anything about meditation then, or had been talking to a therapist or someone to help me through some of the fear that I was steeped in, I think I would have been more calm in how I approached what boundaries I needed to create to thrive," she continued.

"I certainly regret not learning earlier how to manage my anxiety better. Living at that heightened level of anxiety ... created a defensiveness in me and wariness and assuming that people were against me. I let my mind run rampant without the tools to properly manage that."

Heigl recently shared her thoughts on Grey's storyline where her character reunited with Alex Karev (Justin Chambers).

"Wasn't he with someone?" Heigl told Entertainment Tonight on January 27, referencing Alex's wife Jo (Camilla Luddington). "Listen, isn't that an a---hole move?"

Celebrity throwback photos: Guess who!

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Katherine Heigl recalls her controversial exit from Grey's Anatomy - 9TheFIX

‘Grey’s Anatomy’ Alum and ‘Private Practice’ Star Kate Walsh Didn’t Inspire ‘The Sweetest Thing’ – Showbiz Cheat Sheet

Actor Kate Walsh, or Addison to fans of Greys Anatomy and Private Practice, isnt the inspiration for The Sweetest Thing. A remark she made on the movies DVD extras led people to believe her adventures with screenwriter Nancy Pimental inspired it. But thats not true.

A few years after playing the title character in Theres Something About Mary, Cameron Diaz signed on for The Sweetest Thing. The 2002 film follows her character, Christina Walters, as she meets a guy named Peter (Thomas Jane) who could be the one. She sets about tracking him down.

Soon she finds herself on a road trip with her best friend Courtney (Christina Applegate) to what they believe is the wedding of Peters brother, Roger (Jason Bateman).Finding Christinas potential soulmate isnt the only thing she and Courtney are doing. At the time they are on their road trip, theyre trying to encourage their friend Jane (Selma Blair) to start dating again after a breakup.

The Sweetest Thing opened to less than stellar reviews. But in the years since its developed cult status. Its considered by some to be the precursor to women-focused films such as Bridesmaids and Bad Moms.

RELATED: Former Greys Anatomy Star Kate Walsh Reunites With a Private Practice Co-Star What Is the Cast up to in 2020?

Pimental told Entertainment Weekly in 2018 how it came to be general knowledge that her friendship with Walsh served a the inspiration for The Sweetest Thing.

A camera crew came to her house to film a feature for the DVD. She chose a very tongue-in-cheek and ironic video about a day in the life of a bigshot screenwriter. Pimental called all of her actor friends over to help, including Walsh.

Kate had said in this thing that we were best friends and the movie was based on our friendship, Pimental said, noting they improvised everything.

Its so funny how people just said, Oh, well the part that Kate said must be true, she added. Now she and Walsh just laugh about it.

RELATED: Greys Anatomy Alum Kate Walsh Makes Iconic Tribute to Meredith and Dereks Reunion

Pimental set the record straight on the true inspiration. Before she wrote the movie shed been working at a restaurant with a tight-knit group of women.

We just ran in this pack where we were these waitresses, and there was always these write-ups about us in magazines, because the place was really popular and a lot of Saudi princes would go there, she said.

Pimental continued, saying they were owning their womanhood.

There was this group of girls and we were running around town and partying at these different clubs and just owning our womanhood, I guess, she said.

And thats where the inspiration for The Sweetest Thing came in.

I just thought, God, theres not an example of this sort of girl posse where were more like guys. Yeah, we decide if we want to give you a fake number or not kind of thing. There wasnt this empowerment, I guess, or this example of it, she said before adding, Thats really how it started.

Watch The Sweetest Thing on Hulu with a premium subscription or rent it on Amazon Prime.

RELATED:Patrick Dempsey Was Convinced Shonda Rhimes Didnt Want Him to Play Derek Shepherd When He Auditioned for Greys Anatomy

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'Grey's Anatomy' Alum and 'Private Practice' Star Kate Walsh Didn't Inspire 'The Sweetest Thing' - Showbiz Cheat Sheet

The anatomy of the perfect counter-attacking goal after Mohamed Salah’s stunner – Telegraph.co.uk

There is something about the devastating synchronicity of a well executed counter-attack that pulls you to the edge of your seat, even in these strange times when an abundance of live football can make the action grey and indistinguishable. Mohamed Salah's second goal for Liverpool at West Ham was one such moment.

Why does this category of goal resonate and delight to such an extent? Firstly, counter-attacks are an exhibition of the razor-thin margins that decide top-level football matches: a team can be camped in the opposition's penalty area before picking the ball out of their net less than 10 seconds later. What better encapsulation of the emotional swings a fan experiences throughout the 90 minutes?

They are also very difficult to pull off, demanding technical accuracy at pace which is the most sought-after combination in football. Players who can see a pass or produce a piece of skill at walking pace are two-a-penny, as are those with speed but the touch and awareness of a rhinoceros. What separates the great from theaverage is the ability to do both. Wayne Rooney and Cristiano Ronaldo were sensational exponents of this type of football at Manchester United, as were Arsene Wenger's title-winning Arsenal teams who galloped from one end of the pitch to the other like a cavalry charge. Jose Mourinho's best sides at Chelsea and Real Madrid were also famed for slicing through teams with fast breaks. Leicester's 2015-16 champions spearheaded by Jamie Vardy are also a must mention.

Like passing the baton in a relay race, one mistake and the entire sequence breaks down. How often do you see a team butcher a move when they have four-on-two against the defending team? It is not easy as it looks, yet the picture-book goals that result from a well coordinated counter look delightfully simple.

When analysed in its entirety, a 90-minute football match is really a story of mistake after mistake. Often, especially in an erawith so much focus on pressing, the victorious team is the one who makes the fewest. The best counter-attacks on the other hand, are harmonious vignettes of mistake-free football bordering on perfection. That is what makes them, and Salah's goal, so satisfying. Here we pick out some of the essential components.

"Speed is often confused with insight. When I start running earlier than the others, I appear faster," said Johan Cruyff.

Salah is fast by any measure, but the way he sensed what could develop was crucial. As soon as the ball popped out of the penalty area, Salah is sprinting into space before any West Ham players have broken into a jog. You would expect Salah to win the race starting level, but that moment of 'insight' to start sprinting before anyone else has seen the possibilities is what puts clear blue water between the Liverpool forward and West Ham's retreating players.

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The anatomy of the perfect counter-attacking goal after Mohamed Salah's stunner - Telegraph.co.uk

REACH and Millennium Systems International Partner to offer Machine Learning Driven Booking Automation to the MeevoXchange Marketplace – PRNewswire

REACH is available in award-winning Millennium System International's scheduling software product, Meevo 2, and serves thousands of beauty businesses in over 30 countries."We are thrilled to announce another Meevo 2 business building integration offering within our MeevoXchange marketplace REACH by Octopi. REACH delivers the AI-powered smart scheduling features to help keep our salons and spas booked and growing. This partnership aligns with our strategic goals for our award-winning software Meevo 2 as we continuously add value to our platform and ultimately our salon and spa customers," says CEO John Harms, Millennium Systems International.

"REACH is so special because it requires virtually no setup or upkeep as it follows your existing Meevo 2 online booking settings. REACH plays 'matchmaker' by connecting your clients that are due and overdue with open spaces in your Meevo 2 appointment book over the next few days, automatically. It has taken us years of research and development to create such successful and exciting tool that will begin to show value to your business starting on day one!" CEO Patrick Blickman, REACH by Octopi

Performance Guarantee and Affordability

The platform includes the REACH Revenue Guarantee thatensures each location will see a minimum of $600-$1400 in new booking revenue every month. There are never any contracts or commitments with REACH. Simply turn it on and let it start filling your Meevo 2 appointment book. Pricing starts at $149/month.

About REACH by OCTOPI

REACH was founded to make the client booking experience easier and far more automated for the health and beauty businesses we serve. Headquartered in Scottsdale, Arizona; REACH is built on decades of consolidated industry and channel expertise. Visitwww.octopi.com/reach

About Millennium Systems International:

Millennium Systems International has been a leading business management software for the salon, spa and wellness industry for more than three decades. The award-winning Meevo 2 platform provides a true cloud-based business management software that is HIPAA compliant and fully responsive, so users can gain complete access using any device, built by wellness and beauty veterans exclusively for the wellness and beauty industry. Visit https://www.millenniumsi.com

SOURCE Octopi

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REACH and Millennium Systems International Partner to offer Machine Learning Driven Booking Automation to the MeevoXchange Marketplace - PRNewswire

Can Machine Learning be the Best Remedy in the Education Sector? – Analytics Insight

The classrooms in present era are not only expanding to use more technologies and digital tools but they are also engaging in machine learning

Technology in the classroom is becoming more and more popular as we pass through the 21st century. Laptops are replacing our textbooks, and on our smart phones, we can study just about everything we want. Social media has become ubiquitous, and the way we use technology has changed the way we live our lives fully.

Technology has become the core component of distance education programs. It enhances teachers and students to digitally interconnect and exchange material and student work, retaining a human link, which is important for the growth of young minds. Enhanced connections and customized experience can allow educators torecognizeopportunities for learning skills and enhance the potential of a student.

Hence, the classrooms in present era are not only expanding to use more technologies and digital tools but they are also engaging in machine learning.

Machine learning is an artificial intelligence (AI) element, which lets machines or computers learn from all previous knowledge and make smart decisions. The architecture for machine learning involves gathering and storing a rich collection of information and turning it into a standardized knowledge base for various uses in different fields. Educators could save time in their non-classroom practices in the field of education by concentrating on machine learning.

For instance, teachers may use virtual helpers to work for their students directly from home. This form of assistance helps to boost the learning environment of students and can promote growth and educational success.

According to ODSC, Last years report by MarketWatch has revealed that Machine Learning in education will remain one of the top industries to drive investment, with the U.S. and China becoming the top key players by 2030. Major companies, like Google and IBM, are getting involved in making school education more progressive and innovative.

Analyzing all-round material

By making the content more up-to-date and applicable to an exact request, the use of machine learning in education aims to bring the online learning sector to a new stage. How? ML technologies evaluate the content of courses online and help to assess whether the quality of the knowledge presented meets the applicable criteria. On the other hand, know how users interpret the data and understand what is being explained. Users then obtain the data according to their particular preferences and expertise, and the overall learning experience increases dramatically.

Customized Learning

This is the greatest application of machine learning. It is adaptable and it takes care of individual needs. Students are able to guide their own learning through this education system. They can have theirown speed and decide what to study and how to learn. They can select the topics they are interested in, the instructor they want to learn from, and what program they want to pursue, expectations and trends.

Effective Grading

In education, there is another application of machine learning that deals with grades and scoring. Since the learning skills of a large number of students are expressed in each online course, grading them becomes a challenge. ML technology makes the grading process a few seconds problem. In this context, we talk more about the exact sciences. There are places where teachers cannot be replaced by computers, but even in such situations, they can contribute to enhance current approaches of grading and evaluation.

According to TechXplore, Researchers at University of Tbingen and Leibniz Institute fr Wissensmedien in Germany, as well as University of Colorado Boulder, have recently investigated the potential of machine-learning techniques for assessing student engagement in the context of classroom research. More specifically, they devised a deep-neural-network-based architecture that can estimate student engagement by analyzing video footage collected in classroom environments.

They also mentioned that, We used camera data collected during lessons to teach a deep-neural-network-based model to predict student engagement levels, Enkelejda Kasneci the leading HCI researcher in the multidisciplinary team that carried out the study, told TechXplore. We trained our model on ground-truth data (e.g., expert ratings of students level of engagement based on the videos recorded in the classroom). After this training, the model was able to predict, for instance, whether data obtained from a particular student at a particular point in time indicates high or low levels of engagement.

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Can Machine Learning be the Best Remedy in the Education Sector? - Analytics Insight

Microchip Accelerates Machine Learning and Hyperscale Computing Infrastructure with the World’s First PCI Express 5.0 Switches – EE Journal

Switchtec PFX PCIe Gen 5 high performance switches double the data rate of PCIe Gen 4.0 solutions while delivering ultra-low latency and advanced diagnostics

CHANDLER, Ariz., Feb. 02, 2021 (GLOBE NEWSWIRE) Applications such as data analytics, autonomous-driving and medical diagnostics are driving extraordinary demands for machine learning and hyperscale compute infrastructure. To meet these demands, Microchip Technology Inc.(Nasdaq: MCHP)today announced the worlds first PCI Express (PCIe) 5.0 switch solutions theSwitchtec PFX PCIe 5.0 family doubling the interconnect performance for dense compute, high speed networking and NVM Express(NVMe) storage. Together with the XpressConnectretimers, Microchip is the industrys only supplier of both PCIe Gen 5 switches and PCIe Gen 5 retimer products, delivering a complete portfolio of PCIe Gen 5 infrastructure solutions with proven interoperability.

Accelerators, graphic processing units (GPUs), central processing units (CPUs) and high-speed network adapters continue to drive the need for higher performance PCIe infrastructure. Microchips introduction of the worlds first PCIe 5.0 switch doubles the PCIe Gen 4 interconnect link rates to 32 GT/s to support the most demanding next-generation machine learning platforms, said Andrew Dieckmann, associate vice president of marketing and applications engineering for Microchips data center solutions business unit. Coupled with our XpressConnect family of PCIe 5.0 and Compute Express Link(CXL) 1.1/2.0 retimers, Microchip offers the industrys broadest portfolio of PCIe Gen 5 infrastructure solutions with the lowest latency and end-to-end interoperability.

The Switchtec PFX PCIe 5.0 switch family comprises high density, high reliability switches supporting 28 lanes to 100 lanes and up to 48 non-transparent bridges (NTBs). The Switchtec technology devices support high reliability capabilities, including hot-and surprise-plug as well as secure boot authentication. With PCIe 5.0 data rates of 32 GT/s, signal integrity and complex system topologies pose significant development and debug challenges. To accelerate time-to-market, the Switchtec PFX PCIe 5.0 switch provides a comprehensive suite of debug and diagnostic features including sophisticated internal PCIe analyzers supporting Transaction Layer Packet (TLP) generation and analysis and on-chip non-obtrusive SerDes eye capture capabilities. Rapid system bring-up and debug is further supported with ChipLink an intuitive graphical user interface (GUI) based device configuration and topology viewer that provides full access to the PFX PCIe switchs registers, counters, diagnostics and forensic capture capabilities.

Intels upcoming Sapphire Rapids Xeon processors will implement PCI Express 5.0 and Compute Express Link running up to 32.0 GT/s to deliver the low-latency and high-bandwidth I/O solutions our customers need to deploy, said Dr. Debendra Das Sharma, Intel fellow and director of I/O technology and standards. We are pleased to see Microchips PCIe 5.0 switch and retimer investment strengthen the ecosystem and drive broader deployment of PCIe 5.0 and CXL enabled solutions.

Development ToolsMicrochip has released a full set of design-in collateral, reference designs, evaluation boards and tools to support customers building systems that take advantage of the high-bandwidth of PCIe 5.0.

In addition to PCIe technology, Microchip also provides data center infrastructure builders worldwide with total system solutions including RAID over NVMe, storage, memory, timing and synchronization systems, stand-alone secure boot, secure firmware and authentication, wireless products, touch-enabled displays to configure and monitor data center equipment and predictive fan controls.

AvailabilityThe Switchtec PFX PCIe 5.0 family of switches are sampling now to qualified customers. For additional information, contact a Microchip sales representative.

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About Microchip TechnologyMicrochip Technology Inc. is a leading provider of smart, connected and secure embedded control solutions. Its easy-to-use development tools and comprehensive product portfolio enable customers to create optimal designs which reduce risk while lowering total system cost and time to market. The companys solutions serve more than 120,000 customers across the industrial, automotive, consumer, aerospace and defense, communications and computing markets. Headquartered in Chandler, Arizona, Microchip offers outstanding technical support along with dependable delivery and quality. For more information, visit the Microchip website atwww.microchip.com.

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Microchip Accelerates Machine Learning and Hyperscale Computing Infrastructure with the World's First PCI Express 5.0 Switches - EE Journal

The POWER Interview: The Importance of AI and Machine Learning – POWER magazine

Artificial intelligence (AI) and machine learning (ML) are becoming synonymous with the operation of power generation facilities. The increased digitization of power plants, from equipment to software, involves both thermal generation and renewable energy installations.

Both AI and ML will be key elements for the design of future energy systems, supporting the growth of smart grids and improving the efficiency of power generation, along with the interaction among electricity customers and utilities.

The technology group Wrtsil is a global leader in using data to improve operations in the power generation sector. The company helps generators make better asset management decisions, which supports predictive maintenance. The company uses AI, along with advanced diagnostics, and its deep equipment expertise greatly to enhance the safety, reliability, and efficiency of power equipment and systems.

Luke Witmer, general manager, Data Science, Energy Storage & Optimization at Wrtsil, talked with POWER about the importance of AI and ML to the future of power generation and electricity markets.

POWER: How can artificial intelligence (AI) be used in power trading, and with regard to forecasts and other issues?

Witmer: Artificial intelligence is a very wide field. Even a simple if/else statement is technically AI (a computer making a decision). Forecasts for price and power are generated by AI (some algorithm with some historic data set), and represent the expected trajectory or probability distribution of that value.

Power trading is also a wide field. There are many different markets that span different time periods and different electricity (power) services that power plants provide. Its more than just buying low and selling high, though that is a large piece of it. Forecasts are generally not very good at predicting exactly when electricity price spikes will happen. There is always a tradeoff between saving some power capacity for the biggest price spikes versus allocating more of your power for marginal prices. In the end, as a power trader, it is important to remember that the historical data is not a picture of the future, but rather a statistical distribution that can be leveraged to inform the most probable outcome of the unknown future. AI is more capable at leveraging statistics than people will ever be.

POWER: Machine learning and AI in power generation rely on digitalization. As the use of data becomes more important, what steps need to be taken to support AI and machine learning while still accounting for cybersecurity?

Witmer: A lot of steps. Sorry for the lame duck answer here. Regular whitehat penetration testing by ethical hackers is probably the best first step. The second step should be to diligently and quickly address each critical issue that is discovered through that process. This can be done by partnering with technology providers who have the right solution (cyber security practices, certifications, and technology) to enable the data flow that is required.

POWER: How can the power generation industry benefit from machine learning?

Witmer: The benefit is higher utilization of the existing infrastructure. There is a lot of under-utilized intrastructure in the power generation industry. This can be accomplished with greater intelligence on the edges of the network (out at each substation and at each independent generation facility) coupled with greater intelligence at the points of central dispatch.

POWER: Can machines used in power generation learn from their experiences; would an example be that a machine could perform more efficiently over time based on past experience?

Witmer: Yes and no. It depends what you mean by machines. A machine itself is simply pieces of metal. An analogy would be that your air conditioner at home cant learn anything, but your smart thermostat can. Your air conditioner needs to just operate as efficiently as possible when its told to operate, constrained by physics. Power generation equipment is the same. The controls however, whether at some point of aggregation, or transmission intersection, or at a central dispatch center, can certainly apply machine learning to operate differently as time goes on, adapting in real time to changing trends and conditions in the electricity grids and markets of the world.

POWER: What are some of the uses of artificial intelligence in the power industry?

Witmer: As mentioned in the response to question 1, I think it appropriate to point you at some definitions and descriptions of AI. I find wikipedia to be the best organized and moderated by experts.

In the end, its a question of intelligent control. There are many uses of AI in the power industry. To start listing some of them is insufficient, but, to give some idea, I would say that we use AI in the form of rules that automatically ramp power plants up/down by speeding up or slowing down their speed governors, in the form of neural networks that perform load forecasting based on historic data and the present state data (time of day, metering values, etc.), in the form of economic dispatch systems that leverage these forecasts, and in the form of reinforcement learning for statistically based automated bid generation in open markets. Our electricity grids combined with their associated controls and markets are arguably the most complex machines that humans have built.

POWER: How can AI benefit centralized generation, and can it provide cost savings for power customers?

Witmer: Centralized power systems continue to thrive from significant economies of scale. Centralized power systems enable equal access to clean power at the lowest cost, reducing economic inequality. I view large renewable power plants that are owned by independent power producers as centralized power generation, dispatched by centralized grid operators. Regardless of whether the path forward is more or less centralized, AI brings value to all parties. Not only does it maximize revenue for any specific asset (thus the asset owner), it also reduces overall electricity prices for all consumers.

POWER: How important is AI to smart grids? How important is AI to the integration of e-mobility (electric vehicles, etc.) to the grid?

Witmer: AI is very important to smart grids. AI is extremely important to the integration of smart charging of electric vehicles, and leveraging of those mobile batteries for grid services when they are plugged into the grid (vehicles to grid, or V2G). However, the more important piece is for the right market forces to be created (economics), so that people can realize the value (actually get paid) for allowing their vehicles to participate in these kinds of services.

The mobile batteries of EVs will be under-utilized if we do not integrate the controls for charging/discharging this equipment in a way that gives both the consumers the ability to opt in/out of any service but also for the centralized dispatch to leverage this equipment as well. Its less a question of AI, and more a question of economics and human behavioral science. Once the economics are leveraged and the right tools are in place, then AI will be able to forecast the availability and subsequent utility that the grid will be able to extract from the variable infrastructure of plugged in EVs.

POWER: How important is AI to the design and construction of virtual power plants?

Witmer: Interesting question. On one level, this is a question that raises an existential threat to aspects of my own job (but thats a good thing because if a computer can do it, I dont want to do it!). Its a bit of a chicken-and-egg scenario. Today, any power plant (virtual or actual), is designed through a process that involves a lot of modeling, or simulations of what-if scenarios. That model must be as accurate as possible, including the controls behavior of not only the new plant in question, but also the rest of the grid and/or markets nearby.

As more AI is used in the actual context of this new potential power plant, the model must also contain a reflection of that same AI. No model is perfect, but as more AI gets used in the actual dispatch of power plants, more AI will be needed in the design and creation process for new power plants or aggregations of power generation equipment.

POWER: What do you see as the future of AI and machine learning for power generation / utilities?

Witmer: The short-term future is simply an extension of what we see today. As more renewables come onto the grids, we will see more negative price events and more price volatility. AI will be able to thrive in that environment. I suspect that as time goes on, the existing market structures will cease to be the most efficient for society. In fact, AI is likely going to be able to take advantage of some of those legacy features (think Enron).

Hopefully the independent system operators of the world can adapt quickly enough to the changing conditions, but I remain skeptical of that in all scenarios. With growing renewables that have free fuel, the model of vertically integrated utilities with an integrated resource planning (IRP) process will likely yield the most economically efficient structure. I think that we will see growing inefficiencies in regions that have too many manufactured rules and structure imposed by legacy markets, designed around marginal costs of operating fossil fuel-burning plants.

Darrell Proctor is associate editor for POWER (@POWERmagazine).

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The POWER Interview: The Importance of AI and Machine Learning - POWER magazine

Five trends in machine learning-enhanced analytics to watch in 2021 – Information Age

AI usage is growing rapidly. What does 2021 hold for the world of analytics, and how will AI drive it?

Progress of AI-powered operations looks set to grow this year.

As the world prepares to recover from the Covid-19 pandemic, businesses will need to increasingly rely on analytics to deal with new consumer behaviour.

According to Gartner analyst Rita Sallam, In the face of unprecedented market shifts, data and analytics leaders require an ever-increasing velocity and scale of analysis in terms of processing and access to accelerate innovation and forge new paths to a post-Covid-19 world.

Machine learning and artificial intelligence are finding increasingly significant use cases in data analytics for business. Here are five trends to watch out for in 2021.

Gartner predicts that by 2024, 75% of enterprises will shift towards putting AI and ML into operation. A big reason for this is the way the pandemic has changed consumer behaviour. Regression learning models that rely on historical data might not be valid anymore. In their place, reinforcement and distributed learning models will find more use, thanks to their adaptability.

A large share of businesses have already democratised their data through the use of embedded analytics dashboards. The use of AI to generate augmented analytics to drive business decisions will increase as businesses seek to react faster to shifting conditions. Powering data democratisation efforts with AI will help non-technical users make a greater number of business decisions, without having to rely on IT support to query data.

Companies such as Sisense already offer companies the ability to integrate powerful analytics into custom applications. As AI algorithms become smarter, its a given that theyll help companies use low-latency alerts to help managers react to quantifiable anomalies that indicate changes in their business. Also, AI is expected to play a major role in delivering dynamic data stories and might reduce a users role in data exploration.

A fact thats often forgotten in AI conversations is that these technologies are still nascent. Many of the major developments have been driven by open source efforts, but 2021 will see an increasing number of companies commercialise AI through product releases.

This event will truly be a marker of AI going mainstream. While open source has been highly beneficial to AI, scaling these projects for commercial purposes has been difficult. With companies investing more in AI research, expect a greater proliferation of AI technology in project management, data reusability, and transparency products.

Using AI for better data management is a particular focus of big companies right now. A Pathfinder report in 2018 found that a lack of skilled resources in data management was hampering AI development. However, with ML growing increasingly sophisticated, companies are beginning to use AI to manage data, which fuels even faster AI development.

As a result, metadata management becomes streamlined, and architectures become simpler. Moving forward, expect an increasing number of AI-driven solutions to be released commercially instead of on open source platforms.

Vendors such as Informatica are already using AI and ML algorithms to help develop better enterprise data management solutions for their clients. Everything from data extraction to enrichment is optimised by AI, according to the company.

This article explores the ways in which Kubernetes enhances the use of machine learning (ML) within the enterprise. Read here

Voice search and data is increasing by the day. With products such as Amazons Alexa and Googles Assistant finding their way into smartphones and growing adoption of smart speakers in our homes, natural language processing will increase.

Companies will wake up to the immense benefits of voice analytics and will provide their customers with voice tools. The benefits of enhanced NLP include better social listening, sentiment analysis, and increased personalisation.

Companies such as AX Semantics provide self-service natural language generation software that allows customers to self-automate text commands. Companies such as Porsche, Deloitte and Nivea are among their customers.

As augmented analytics make their way into embedded dashboards, low-level data analysis tasks will be automated. An area that is ripe for automation is data collection and synthesis. Currently, data scientists spend large amounts of time cleaning and collecting data. Automating these tasks by specifying standardised protocols will help companies employ their talent in tasks better suited to their abilities.

A side effect of data analysis automation will be the speeding up of analytics and reporting. As a result, we can expect businesses to make decisions faster along with installing infrastructure that allows them to respond and react to changing conditions quickly.

As the worlds of data and analytics come closer together, vendors who provide end-to-end stacks will provide better value to their customers. Combine this with increased data democratisation and its easy to see why legacy enterprise software vendors such as SAP offer everything from data management to analytics to storage solutions to their clients.

Tech experts provide their tips on how to effectively implement automation into your customer relationship management (CRM) process. Read here

IoT devices are making their way into not just B2C products but B2B, enterprise and public projects as well, from smart cities to industry 4.0.

Data is being generated at unprecedented rates, and to make sense of it, companies are increasingly turning to AI. With so much signal, this is a key help for arriving at insights.

While the rise of embedded and augmented analytics has already been discussed, its critical to point out that the sources of data are more varied than ever before. This makes the use of AI critical, since manual processes cannot process such large volumes efficiently.

As AI technology continues to make giant strides the business world is gearing up to take full advantage of it. Weve reached a stage where AI is powering further AI development, and the rate of progress will only increase.

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Five trends in machine learning-enhanced analytics to watch in 2021 - Information Age

BioSig and Mayo Clinic Collaborate on New R&D Program to Develop Transformative AI and Machine Learning Technologies for its PURE EP System – BioSpace

Westport, CT, Feb. 02, 2021 (GLOBE NEWSWIRE) --

BioSig Technologies, Inc. (NASDAQ: BSGM) (BioSig or the Company), a medical technology company commercializing an innovative signal processing platform designed to improve signal fidelity and uncover the full range of ECG and intra-cardiac signals, today announced a strategic collaboration with the Mayo Foundation for Medical Education and Research to develop a next-generation AI- and machine learning-powered software for its PURE EP system.

The new collaboration will include an R&D program that will expand the clinical value of the Companys proprietary hardware and software with advanced signal processing capabilities and aim to develop novel technological solutions by combining the electrophysiological signals delivered by the PURE EPand other data sources. The development program will be conducted under the leadership of Samuel J. Asirvatham, M.D., Mayo Clinics Vice-Chair of Innovation and Medical Director, Electrophysiology Laboratory, and Alexander D. Wissner-Gross, Ph.D., Managing Director of Reified LLC.

The global market for AI in healthcare is expected to grow from $4.9 billion in 2020 to $45.2 billion by 2026 at an estimated compound annual growth rate (CAGR) of 44.9%1. According to Accenture, key clinical health AI applications, when combined, can potentially create $150 billion in annual savings for the United States healthcare economy by 20262.

AI-powered algorithms that are developed on superior data from multiple biomarkers could drastically improve the way we deliver therapies, and therefore may help address the rising global demand for healthcare, commented Kenneth L Londoner, Chairman and CEO of BioSig Technologies, Inc. We believe that combining the clinical science of Mayo Clinic with the best-in-class domain expertise of Dr. Wissner-Gross and the technical leadership of our engineering team will enable us to develop powerful applications and help pave the way toward improved patient outcomes in cardiology and beyond.

Artificial intelligence presents a variety of novel opportunities for extracting clinically actionable information from existing electrophysiological signals that might otherwise be inaccessible. We are excited to contribute to the advancement of this field, said Dr. Wissner-Gross.

BioSig announced its partnership with Reified LLC, a provider of advanced artificial intelligence-focused technical advisory services to the private sector in late 2019. The new research program builds upon the progress achieved by this collaboration in 2020, which included an abstract for Computational Reconstruction of Electrocardiogram Lead Placement presented during the 2020 Computing in Cardiology Conference in Rimini, Italy, and the development of an initial suite of electrophysiological analytics for the PURE EPSystem.

BioSig signed a 10-year collaboration agreement with Mayo Clinic in March 2017. In November 2019, the Company announced that it signed three new patent and know-how license agreements with the Mayo Foundation for Medical Education and Research.

About BioSig TechnologiesBioSig Technologies is a medical technology company commercializing a proprietary biomedical signal processing platform designed toimprove signal fidelity and uncover the full range of ECG and intra-cardiac signals(www.biosig.com).

The Companys first product,PURE EP Systemis a computerized system intended for acquiring, digitizing, amplifying, filtering, measuring and calculating, displaying, recording and storing of electrocardiographic and intracardiac signals for patients undergoing electrophysiology (EP) procedures in an EP laboratory.

Forward-looking Statements

This press release contains forward-looking statements. Such statements may be preceded by the words intends, may, will, plans, expects, anticipates, projects, predicts, estimates, aims, believes, hopes, potential or similar words. Forward- looking statements are not guarantees of future performance, are based on certain assumptions and are subject to various known and unknown risks and uncertainties, many of which are beyond the Companys control, and cannot be predicted or quantified and consequently, actual results may differ materially from those expressed or implied by such forward-looking statements. Such risks and uncertainties include, without limitation, risks and uncertainties associated with (i) the geographic, social and economic impact of COVID-19 on our ability to conduct our business and raise capital in the future when needed, (ii) our inability to manufacture our products and product candidates on a commercial scale on our own, or in collaboration with third parties; (iii) difficulties in obtaining financing on commercially reasonable terms; (iv) changes in the size and nature of our competition; (v) loss of one or more key executives or scientists; and (vi) difficulties in securing regulatory approval to market our products and product candidates. More detailed information about the Company and the risk factors that may affect the realization of forward-looking statements is set forth in the Companys filings with the Securities and Exchange Commission (SEC), including the Companys Annual Report on Form 10-K and its Quarterly Reports on Form 10-Q. Investors and security holders are urged to read these documents free of charge on the SECs website at http://www.sec.gov. The Company assumes no obligation to publicly update or revise its forward-looking statements as a result of new information, future events or otherwise.

1 Artificial Intelligence in Healthcare Market with COVID-19 Impact Analysis by Offering, Technology, End-Use Application, End User and Region Global Forecast to 2026; Markets and Markets

2 Artificial Intelligence (AI): Healthcares New Nervous System https://www.accenture.com/us-en/insight-artificial-intelligence-healthcare%C2%A0

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BioSig and Mayo Clinic Collaborate on New R&D Program to Develop Transformative AI and Machine Learning Technologies for its PURE EP System - BioSpace

When Are We Going to Start Designing AI With Purpose? Machine Learning Times – The Predictive Analytics Times

Originally published in UX Collective, Jan 19, 2021.

For an industry that prides itself on moving fast, the tech community has been remarkably slow to adapt to the differences of designing with AI. Machine learning is an intrinsically fuzzy science, yet when it inevitably returns unpredictable results, we tend to react like its a puzzle to be solved; believing that with enough algorithmic brilliance, we can eventually fit all the pieces into place and render something approaching objective truth. But objectivity and truth are often far afield from the true promise of AI, as well soon discuss.

I think a lot of the confusion stems from language;in particular the way we talk about machine-like efficiency. Machines are expected to make precise measurements about whatever theyre pointed at; to produce data.

But machinelearningdoesnt produce data. Machine learning producespredictionsabout how observations in the present overlap with patterns from the past. In this way, its literally aninversionof the classicif-this-then-thatlogic thats driven conventional software development for so long. My colleague Rick Barraza has a great way of describing the distinction:

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When Are We Going to Start Designing AI With Purpose? Machine Learning Times - The Predictive Analytics Times

Learn in-demand technical skills in Python, machine learning, and more with this academy – The Next Web

Credit: Clment Hlardot/Unsplash

TLDR: With access to the Zenva Academy, users can take over 250 tech courses packed with real world programming training to become a knowledgeable and hirable professional coder.

The tech industry is expected to grow by as many as 13 million new jobs in the U.S. alone over the next five years, with another 20 million likely to spring up in the EU.

And you can rest assured that coding will be at the heart of almost every single one of those new positions.

Its no surprise that programming courses are being taught to our youngest students these days. From web development to gaming to data science, all the tech innovations well see over those next five years and beyond will come from innovators who understand how to make those static lines of code get together and dance.

If you feel behind the programming curve or just want a stockpile of tech training to have you ready for anything, the Zenva Academy ($139.99 for a one-year subscription) may be just the bootcamp you need to grab one of those new jobs.

This access unlocks everything in the Zenva Academys vast archives, a collection of more than 250 courses that dive into every aspect of learning to build games, websites, apps and more.

With courses taught by knowledgeable industry professionals, even newbies coming in with zero experience receive world-class training on in-demand programming skills on their way to becoming professionals themselves. Classes are based entirely around your own schedule with no deadlines or due dates so you can work at your own pace on bolstering your abilities.

Whether a student is interested in crafting mobile apps, mastering data science, or exploring machine learning and AI, these courses dont just tell you how to interact with these disciplines, they actually show you. Zenva coursework is based around creating real projects in tandem with the learning.

As you build a VR or AR app, or craft your first artificial neural networks using Python and TensorFlow, or create an awesome game, youll be building work for a professional portfolio that can help you land one of these prime coding positions. And with their ties to elite developer programs for outlets like Intel, Microsoft, and CompTIA, students can get on the fast track toward getting hired.

Regularly $169 for a year of Zenva Academy access, you can get it foronly $139.99 for a limited time.

Prices are subject to change.

Read next: Forget Hyperloop, check out Chinas new 620kmph maglev prototype

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What is Machine Learning and its Uses? – Technotification

What is Machine Learning?

A useful way to introduce the machine learning methodology is by means of a comparison with the conventional engineering design flow.

This starts with an in-depth analysis of the problem domain, which culminates with the definition of a mathematical model. The mathematical model is meant to capture the key features of the problem under study and is typically the result of the work of a number of experts. The mathematical model is finally leveraged to derive hand-crafted solutions to the problem.

For instance, consider the problem of defining a chemical process to produce a given molecule. The conventional flow requires chemists to leverage their knowledge of models that predict the outcome of individual chemical reactions, in order to craft a sequence of suitable steps that synthesize the desired molecule. Another example is the design of speech translation or image/ video compression algorithms. Both of these tasks involve the definition of models and algorithms by teams of experts, such as linguists, psychologists, and signal processing practitioners, not infrequently during the course of long standardization meetings.

The engineering design flow outlined above may be too costly and inefficient for problems in which faster or less expensive solutions are desirable. The machine learning alternative is to collect large data sets, e.g., of labeled speech, images, or videos, and to use this information to train general-purpose learning machines to carry out the desired task. While the standard engineering flow relies on domain knowledge and on design optimized for the problem at hand, machine learning lets large amounts of data dictate algorithms and solutions. To this end, rather than requiring a precise model of the set-up understudy, machine learning requires the specification of an objective, of a model to be trained, and of an optimization technique.

Returning to the first example above, a machine learning approach would proceed by training a general-purpose machine to predict the outcome of known chemical reactions based on a large data set, and by then using the trained algorithm to explore ways to produce more complex molecules. In a similar manner, large data sets of images or videos would be used to train a general-purpose algorithm with the aim of obtaining compressed representations from which the original input can be recovered with some distortion.

When to Use Machine Learning?

Based on the discussion above, machine learning can offer an efficient alternative to the conventional engineering flow when development cost and time are the main concerns, or when the problem appears to be too complex to be studied in its full generality. On the flip side, the approach has the key disadvantages of providing generally suboptimal performance, or hindering interpretability of the solution, and applying only to a limited set of problems. In order to identify tasks for which machine learning methods may be useful, suggests the following criteria:1. the task involves a function that maps well-defined inputs to well-defined outputs;2. large data sets exist or can be created containing input-output pairs;3. the task provides clear feedback with clearly definable goals and metrics;4. the task does not involve long chains of logic or reasoning that depend on diverse background knowledge or common sense;5. the task does not require detailed explanations for how the decision was made;6. the task has a tolerance for error and no need for provably correct or optimal solutions;7. the phenomenon or function being learned should not change rapidly over time; and8. no specialized dexterity, physical skills, or mobility is required.

These criteria are useful guidelines for the decision of whether the machine learning methods are suitable for a given task of interest. They also offer a convenient demarcation line between machine learning as is intended today, with its focus on training and computational statistics tools, and more general notions of Artificial Intelligence (AI) based on knowledge and common sense.

In short, Machine learning is very useful and so progressive in the field of programming and topics related to computers.

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What is Machine Learning and its Uses? - Technotification

Long-Term Immunotherapy Linked to Reduced Relapse in Relapsing-Remitting MS – Neurology Advisor

Long-term disease modifying therapies for patients with multiple sclerosis (MS) were effective at reducing relapse and disability accumulation, according to study results published in Neurology.

The predominant goal of MS treatments is the prevention of long-term disability accrual. Study researchers sought to determine whether immunotherapy could prevent long-term disability in patients with relapsing-remitting MS.

In this observational cohort study, researchers assessed patients (N=14,717) with MS who were eligible for class IV immunotherapy. They collected patient data from the MSBase registry.

71% of patients were women (mean age, 36 years; mean age at disease onset, 309 years) and had a median of 6 (interquartile range [IQR], 3.1-10) years of prospective follow-up data. Patients had a median of 4 (IQR, 2-6) relapses, and 69% were exposed to immunotherapies. A total of 1085 patients had at least 15 years of follow-up data (median years of prospective follow-up, 17 years; 95% CI, 15.6-18.8).

Patients who received continuous treatment were less likely to have a relapse event compared with those who were not continuously treated (annual relapse rate, 0.32 vs 0.46, respectively; hazard ratio [HR], 0.60; 95% CI, 0.43-0.82; P =.0016) and less likely to have a 12-month confirmed disability accumulation event (disability accumulation, 0.9 vs 1.5 events, respectively, at 15 years; HR, 0.56; 95% CI, 0.38-0.82; P =.0026).

Compared to untreated patients, fewer patients with continuous treatment reached an Expanded Disability Status Scale (EDSS) step 6 at 15 years (41% vs 13%, respectively; HR, 0.33; 95% CI, 0.19-0.59; P =.00019).

Study researchers did not observe significant difference in disability improvement between the treated and untreated patients (HR, 1.20; 95% CI, 0.96-1.50; P =.1). They also observed similar patterns, stratified by disease duration and age, between these two cohorts.

Limitations of this study include its observational design, the inability to assess delayed treatment effects, and the inability to generalize findings beyond patients with MS followed in academic centers.

These data indicated patients receiving long-term immunotherapy were at decreased risk for disease relapse and neurologic disability escalation. The study authors concluded that sustained, long-term immunotherapy from early stages of MS is advisable as a strategy to preserve patients neurological capacity over the long-term.

Disclosure: Multiple authors declared affiliations with the pharmaceutical industry. Please refer to the original article for a full list of disclosures.

Reference

Kalincik T, Diouf I, Sharmin S, et al. Effect of Disease Modifying Therapy on Disability in Relapsing-Remitting Multiple Sclerosis Over 15 Years. Neurology. Published online December 28, 2020. doi:10.1212/WNL.0000000000011242

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Long-Term Immunotherapy Linked to Reduced Relapse in Relapsing-Remitting MS - Neurology Advisor

Internet-Based Intervention for Sleep in Adults with Mild Cognitive Impairment – Neurology Advisor

Internet-based intervention that includes daily reminders to complete sleep diaries and wear actiwatch can potentially improve sleep in older adults with mild cognitive impairment (MCI), according to study results published in Alzheimers & Dementia.

Patients with MCI are at increased risk for sleep disturbances, and internet-based interventions may aid in improving sleep in this population. As limited data exist on the role of technology in this population, this study aimed at using an existing internet-delivered cognitive behavioral therapy for insomnia, called Sleep Healthy Using the Internet for Older Adult Sufferers of Insomnia and Sleeplessness (SHUti OASIS). SHUti Oasis collects daily sleep diary data and delivers the automated intervention throughout 9 weeks.

In this ongoing study, researchers collected daily sleep diary data using wrist-worn actigraphs over a 14-day period before the intervention and over a 14-day period after the intervention. SHUTi OASIS sent daily morning emails to remind participants to complete the sleep diary and wear the actiwatch at night.

The study sample included 7 patients (mean age 76.0 years; women, 4) and 4 spouses. All patients with MCI completed 10 sleep diaries over the course of 14 days. Most accessed the SHUTi OASIS program daily and wore the actiwatch between 5 and 14 days.

The automated e-mail reminders and logging into SHUTi OASIS program may be associated with the completion of participants sleep diaries. Inconsistent use of actigraphy at night may be secondary to the early-morning timing of e-mail reminders.

Incorporating technology for subjective and objective sleep data collection in this population is promising, and future work should consider frequency and timing of reminders with multimodal technology use, concluded the study researchers.

Reference

Mattos MK, Barnes L, Davis EM, et al. Preliminary feasibility of technology use in an internet-delivered intervention: Improving sleep in older adults with mild cognitive impairment. Alzheimers Dement. Published online December 7, 2020. doi:10.1002/alz.038831

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Internet-Based Intervention for Sleep in Adults with Mild Cognitive Impairment - Neurology Advisor

electroCore Announces Full Enrollment of TR-VENUS study of Non-Invasive Vagal Nerve Stimulation (nVNS) for the Acute Treatment of Stroke – BioSpace

ROCKAWAY, N.J., Feb. 02, 2021 (GLOBE NEWSWIRE) -- electroCore Inc.(Nasdaq: ECOR), a commercial-stage bioelectronic medicine company, today announced that full enrollment has been achieved for the TR-VENUS study of non-invasive vagal nerve stimulation (nVNS) for the acute treatment of stroke. TR-VENUS is a double blind, randomized, sham-controlled, multi-center clinical trial, conducted at nine major medical centers across Turkey, supported by the Turkish Neurological Society and partially funded through an unrestricted research grant from electroCore.

Stroke is the second highest cause of death and the third leading cause of disability globally . Ischemic stroke, caused by arterial occlusion, is the most common type of stroke. The effectiveness of current management strategies (e.g. rapid reperfusion with intravenous thrombolysis and endovascular thrombectomy) is dependent on time to treatment. Treating stroke quickly and safely is imperative for maximizing the therapeutic benefits of therapy. electroCores small and portable nVNS device, gammaCore Sapphire, offers the opportunity for administration rapidly after the onset of stroke. The scientific hypothesis supporting the TR-VENUS study is based, in part, on preclinical evidence from studies conducted in the lab of Ilknur Ay at Massachusetts General Hospital, Harvard Medical School suggesting that vagus nerve stimulation (VNS) results in a protective effect against ischemic brain injury1.

The TR-VENUS study recruited a total of 60 subjects with ischemic stroke and eight subjects with hemorrhagic stroke. The primary objective was to assess the safety of nVNS in the setting of acute stroke by examining decreases in arterial blood pressure, severe bradycardia, progression of neurological deficits and death. Feasibility was also assessed by determining the proportion of allocated stimulation doses that could be administered. Secondary efficacy outcomes evaluated neurologic deficits and infarct growth. Top-line data will be reported once available and full results will be published in a peer reviewed medical journal later this year.

The lead investigators of the study, Professors Ethem Murat Arsava and Mehmet Akif Topcuoglu of the Department of Neurology, Hacettepe University in Ankara, Turkey, commented, We are very pleased to have successfully completed enrollment of this Phase 2 trial to assess the safety and feasibility of nVNS for the acute treatment of stroke. We are hopeful that nVNS might be a viable option to improve the treatment of acute stroke.

We congratulate and thank the investigators, patients and families that all supported the successful completion of study enrollment and we look forward to the data readout and what it tells us about nVNS potential as an acute treatment for stroke, saidEric Liebler, Senior Vice President of Neurology at electroCore.

For complete details on the study design please see clintrials.gov: https://clinicaltrials.gov/ct2/show/NCT03733431?term=NCT03733431&draw=2&rank=1

About gammaCoregammaCore(nVNS) is the first non-invasive, hand-held medical therapy applied at the neck as an adjunctive therapy to treat migraine and cluster headache through the utilization of a mild electrical stimulation to the vagus nerve that passes through the skin. Designed as a portable, easy-to-use technology, gammaCore can be self-administered by patients, as needed, without the potential side effects associated with commonly prescribed drugs. When placed on a patients neck over the vagus nerve, gammaCore stimulates the nerves afferent fibers, which may lead to a reduction of pain in patients.

gammaCore is FDA cleared inthe United Statesfor adjunctive use for the preventive treatment of cluster headache in adult patients, the acute treatment of pain associated with episodic cluster headache in adult patients, the acute treatment of pain associated with migraine headache in adult patients, and the prevention of migraine in adult patients. gammaCore is CE-marked in theEuropean Union for the acute and/or prophylactic treatment of primary headache (Migraine, Cluster Headache, Trigeminal Autonomic Cephalalgias and Hemicrania Continua) and Medication Overuse Headache in adults. In 2019, NICE published an evidence-based Medical Technology Guidance document recommending the use of gammaCore for cluster headache withinNHSEngland.

In the US, the FDA has not cleared gammaCore for the treatment of pneumonia and/or respiratory disorders such as acute respiratory stress disorder associated with COVID-19. Please refer to the gammaCore Instructions for Use for all of the important warnings and precautions before using or prescribing this product.

The United States FDA has authorized use of the gammaCore Sapphire CV device for acute use at home or in a healthcare setting to treat adult patients with known or suspected COVID-19 who are experiencing exacerbation of asthma-related dyspnea and reduced airflow, and for whom approved drug therapies are not tolerated or provide insufficient symptom relief as assessed by their healthcare provider, by using non-invasive vagus nerve stimulation (VNS) on either side of the patients neck, available under an emergency access mechanism called an EUA.

gammaCore Sapphire CV has neither been cleared nor approved for acute use at home or in a healthcare setting to treat adult patients with known or suspected COVID-19 who are experiencing exacerbation of asthma-related dyspnea and reduced airflow, and for whom approved drug therapies are not tolerated or provide insufficient symptom relief as assessed by their healthcare provider, by using non-invasive Vagus nerve Stimulation (nVNS) on either side of the patients neck during the Coronavirus Disease 2019 (COVID-19) pandemic.

gammaCore Sapphire CV has been authorized for the above emergency use by FDA under an Emergency Use Authorization.

gammaCore Sapphire CV has been authorized only for the duration of the declaration that circumstances exist justifying the authorization of the emergency use of medical devices under section 564(b)(1) of the Act, 21 U.S.C. 360bbb-3(b)(1), unless the authorization is terminated or revoked.

Further information is available at:

Authorization Letter:https://www.fda.gov/media/139967/download

Fact Sheet for Healthcare Providers:https://www.fda.gov/media/139968/download

Fact Sheet for Patients:https://www.fda.gov/media/139969/download

Instructions for gammaCore usehttps://www.fda.gov/media/139970/download

About electroCore, Inc.

electroCore, Inc. is a commercial stage bioelectronic medicine company dedicated to improving patient outcomes through its platform non-invasive vagus nerve stimulation therapy initially focused on the treatment of multiple conditions in neurology. The companys current indications are the preventative treatment of cluster headache and migraine and acute treatment of migraine and episodic cluster headache.

For more information, visitwww.electrocore.com.

Forward-Looking StatementThis press release may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include, but are not limited to, statements about electroCore's business prospects, sales and marketing, and product development plans, future cash flow projections, anticipated costs, its pipeline or potential markets for its technologies, the availability and impact of payer coverage, the potential product use for other indications, the results of TR-VENUS study and the potential use of gammaCore for the acute treatment of stroke, and other statements that are not historical in nature, particularly those that utilize terminology such as "anticipates," "will," "expects," "believes," "intends," other words of similar meaning, derivations of such words and the use of future dates. Actual results could differ from those projected in any forward-looking statements due to numerous factors. Such factors include, among others, the ability to raise the additional funding needed to continue to pursue electroCores business, sales and marketing, and product development plans, the inherent uncertainties associated with developing new products or technologies, the ability to successfully commercialize gammaCore, competition in the industry in which electroCore operates and overall market conditions. Any forward-looking statements are made as of the date of this press release, and electroCore assumes no obligation to update the forward-looking statements or to update the reasons why actual results could differ from those projected in the forward-looking statements, except as required by law. Investors should consult all of the information set forth herein and should also refer to the risk factor disclosure set forth in the reports and other documents electroCore files with theSECavailable atwww.sec.gov.

Investors:Hans VitzthumLifeSci Advisors617-430-7578hans@lifesciadvisors.com

or

Media Contact:Jackie DorskyelectroCore973-290-0097

1 Ay I, Nasser R, Simon B, Ay H. Transcutaneous Cervical Vagus Nerve Stimulation Ameliorates Acute Ischemic Injury in Rats. Brain Stimul. 2016 Mar-Apr;9(2):166-73. doi: 10.1016/j.brs.2015.11.008. Epub 2015 Dec 1. PMID: 26723020; PMCID: PMC4789082.

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electroCore Announces Full Enrollment of TR-VENUS study of Non-Invasive Vagal Nerve Stimulation (nVNS) for the Acute Treatment of Stroke - BioSpace

Eisai and BioLabs Partner to Create the Eisai Innovation Center BioLabs – PRNewswire

CAMBRIDGE, Mass., Feb. 2, 2021 /PRNewswire/ --Eisai Inc., the U.S. pharmaceutical subsidiary of Eisai Co., Ltd. and BioLabs announced today the launch of the Eisai Innovation Center BioLabs, a shared lab and office space for start-ups aiming to innovate in the complex field of neurological diseases. The incubator space is located at the Eisai Center for Genetics Guided Dementia Discovery (G2D2) facility and will become part of BioLabs' national biotechnology network.

"We are excited to announce this collaboration with BioLabs," said Nadeem Sarwar, Ph.D. and President of G2D2. "This specialized incubator will be the first of its kind. With BioLabs' focus on building ecosystems that foster rapid innovation combined with G2D2's state-of-the-art technology to support neurological research, we believe the creation of the Eisai Innovation Center BioLabs will fuel new scientific discoveries and insights. With more than 50 million people globally living with dementia1, there has never been a greater need for the discovery of novel approaches to prevention and treatment."

Housed in the G2D2 facility, the Eisai Innovation Center BioLabs aims to host five to seven neurology-focused start-ups and provide the infrastructure and support to help build their biotech companies. The facility was custom-designed for discovery research, including capabilities for in-vitro biology, molecular and cellular biology including BioSafety Level 2 tissue culture, microscopy, chemical and structural biology and screening. Companies hosted at this incubator will have the opportunity to access the BioLabs network, and interact with the Eisai network, including G2D2 and Eisai's investment arm, Eisai Innovation Inc.

"Launching this incubator space in partnership with BioLabs is an important milestone in our relentless pursuit of a cure for neurological diseases, including Alzheimer's disease, and the fulfillment of our human health care mission. In this new specialized model, we want to advance beyond offering only co-working space," said Vanessa Almendro, MBA, Ph.D. and Head of Strategy and External Innovation at G2D2. "By providing scientific support and enabling potential collaborative opportunities, the Eisai Innovation Center BioLabs is pioneering in providing unique, broad and tailored support to the most prominent biotech companies developing transformative therapies, devices and digital solutions for patients suffering from neurological disorders."

The integration with BioLabs, a national, membership-based network of shared lab and office facilities located in key biotech innovation clusters, empowers companies to rapidly launch their operations in a full-equipped, ready-to-use facility, while collaborating with other innovators in the field.

"The custom-designed space at G2D2 is an ideal home for the Eisai Innovation Center BioLabs. The open-lab layout naturally fosters integration between entrepreneurs, all focused on understanding and advancing the field of neurological diseases. Interacting with a community of peers, specifically within a specialized area of research, sparks collaboration and can significantly fast track a start-up's evolution," said Adam Milne, Chief Operating Officer at BioLabs.

A joint selection committee with members of Eisai Inc., Eisai Innovation Inc. and BioLabs representatives will select the companies to be invited. The selection committee will prioritize start-ups focused on neurology, aligned with Eisai's human health care mission and showing strong potential to develop curative therapeutics. To learn more about the incubator, visit our website.

About Eisai Inc. At Eisai Inc., human health care (hhc)is our goal. We give our first thoughts to patients and their families, and helping to increase the benefits health care provides. As the U.S. pharmaceutical subsidiary of Tokyo-based Eisai Co., Ltd., we have a passionate commitment to patient care that is the driving force behind our efforts to discover and develop innovative therapies to help address unmet medical needs.

Eisai is a fully integrated pharmaceutical business that operates in two global business groups: oncology and neurology (dementia-related diseases and neurodegenerative diseases). Our U.S. headquarters, commercial and clinical development organizations are located in New Jersey; our discovery labs are in Massachusetts and Pennsylvania; and our global demand chain organization resides in Maryland and North Carolina. To learn more about Eisai Inc., please visit us at http://www.eisai.com/US and follow us on Twitter and LinkedIn.

About Eisai Innovation, Inc.Eisai Innovation, Inc.(EII) is a subsidiary of Eisai Inc. It is a strategic investment organization aspiring to identify synergies between the scientific community and the Eisai network of companies. EII contributes toour human health care (hhc)mission by prioritizing disease prevention, prediction and treatment through global investments and research collaboration.

About G2D2Eisai Center for Genetics Guided DementiaDiscovery (G2D2) is the first research center focused on immunodementia. As part of Eisai's Neurology Business Group, G2D2 draws upon Eisai's cutting-edge strengths in human genetics, data sciences and precision chemistry to accelerate discovery of breakthrough immunodementia precision therapeutics.

G2D2 is located in the Alewife Research Center in the Alewife area, in the north-west part of Cambridge, which is one of the world's leading biotechnology clusters where private research organizations in addition to academic institutions such as Harvard University, the Massachusetts Institute of Technology and Tufts University are concentrated. Leveraging the benefits of the location, a research space that can be used by external organizations will be set up at G2D2 to enhance collaboration with outstanding researchers and open innovation initiatives to promote immunodementia drug discovery.

About BioLabsBioLabsis a membership-based network of shared lab facilities located in the nation's key biotech innovation clusters, designed exclusively for high-potential, early-stage life science companies. It offers co-working environments that pair premium, fully equipped and supported lab and space with unparalleled access to capital and industry partners. Find out more athttps://www.biolabs.io/

References

Contact:

Eisai Inc. Libby Holman201-753-1945 [emailprotected]

SOURCE Eisai Inc.

http://www.eisai.com

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Eisai and BioLabs Partner to Create the Eisai Innovation Center BioLabs - PRNewswire