Exterior the Wire director explains how Anthony Mackie was became a cyborg – The Shepherd of the Hills Gazette

Pilou Asbk as Victor Koval (left) and Anthony Mackie as Capt. Leo in the Netflix film Outside the Wire.

Netflix

Over his career, the Swedish filmmaker Mikael Hfstrm has worked with some of Hollywoods biggest stars, like Arnold Schwarzenegger, Sylvester Stallone, Jennifer Aniston, John Cusack and Anthony Hopkins. Its hard to imagine that he got his start as a writer for Swedish television shows. In 2004, his film Evil received an Academy Award nomination for Best Foreign Language Film, and thats when he went from directing films in Sweden to helming movies in Hollywood.

Hfstrms newest film is Outside the Wire, on Netflix. It stars Anthony Mackie as a top secret android army officer who recruits a drone pilot, played by Damson Idris, to stop a nuclear attack. The sci-fi thriller delves into philosophical questions about humans and morality. The relationship between Mackie and Idris echoes the relationship Denzel Washingtons and Ethan Hawkes characters had in the film Training Day.

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On CNETs Im So Obsessed podcast, Hfstrm explains the challenge of finding the perfect look on screen for Mackies cyborg character, Captain Leo.

He is a bio technical prototype. He looks like you and me, said Hfstrm. One of the biggest jobs, obviously, was to try to figure out exactly what he looked like. What his interior looked like. I dont know how many versions we went through to find something that didnt feel overdone, but was also visually interesting. And hopefully its something that we havent seen in other movies.

During our conversation, we discussed the parallels between the way nuclear weapons are shown in popular culture and the way they are secretly present in all of our lives. Hfstrm also shares what it was like working with both Schwarzenegger and Stallone in the film Escape Plan.

It was a good thing that they were both in the movie, because they were sort of competing at being the nicest guy on set, said Hfstrm with a laugh. They were older, and their rivalry had passed. And now they were old friends sitting on set smoking cigars, telling war stories and it was just a good time.

You can listen to my entire conversation with Hfstrm on Spotify or Apple Podcasts. You can watch Outside the Wire on Netflix. Also, you can subscribe to Im So Obsessed on your favorite podcast app. In each episode, Connie Guglielmo or I catch up with an artist, actor or creator to learn about work, career and current obsessions.

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Exterior the Wire director explains how Anthony Mackie was became a cyborg - The Shepherd of the Hills Gazette

Producer Accused By Ray Fisher Revealed That the Actor Was Upset Because They Wanted Him to Say Cyborg’s Catchphrase – Epicstream

Cyborg actor Ray Fisher asked why some fans are taking anissue as to why his character does not say the catchphrase, Booyah, in Zack Snyders Justice League. The actor asked fans on Twitter. This question isnt all too innocent if the basis will be producer Jon Berg who revealed that the actor didnt want to say the catchphrase when asked to do so.

On Twitter, Fisher asked fans with a serious reflective question to fans who are taking issue with Cyborg not saying the word booyah in Snyders cut. He added that are those fans just as upset when none of the other characters use their catchphrases.

He ended the question that if the fans are not bothered with the other characters not saying their catchphrases, why are they taking issue if Cyborg doesnt say it.

The actors fans flocked to the tweet to show support for him not wanting to say the catchphrase. However, his question might be loaded. In July 2020, Fisher accused Joss Whedon of engaging with gross, abusive, unprofessional, and completely unacceptable behavior during the reshoots for Justice League.

The actor added that producers Jon Berg and Geoff Johns enabled Whedons behavior. Berg responded that Fishers accusations were categorically untrue. The producer added that he remembered a time that Fisher was upset because they wanted him to say Booyaa.

The producer said that it was a famous catchphrase of Cyborg in the animated series. Berg said, "I remember [Fisher] being upset that we wanted him to say Booyaa, which is a well-known saying of Cyborg in the animated series."

Warner Bros launched an investigation into the allegations but was later followed by a third-party investigation due to Fishers request. In December 2020, Warner Media announced the investigation was completed and remedial action was done based on the investigations findings.

Fisher, later on, said that he will not take part in any projects on Warner Bros. if its overseen by DC Films Walter Hamada, calling him a dangerous enabler. Despite the fiasco, the actor said that he will promote Zack Snyders Justice League. The actor said, "There's no way you can stop me from doing press for Zack Snyder's Justice League."

Zack Snyders Justice League will be released on HBO Max on March 18, 2021.

Related:Ray Fisher Insists on Promoting Justice League Snyder Cut Despite Ongoing WB Drama

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Producer Accused By Ray Fisher Revealed That the Actor Was Upset Because They Wanted Him to Say Cyborg's Catchphrase - Epicstream

Superfight vs. Kayla Harrison Could Have Happened Already – Heavy.com

Bellator MMA womens featherweight champion Cris Cyborg recently expressed interest in a superfight showdown with 2019 PFL womens lightweight champion Kayla Harrison, but according to a source the megafight could have already happened at 155 had Cyborg signed with the PFL in 2019.

In fact, Cyborg vs. Harrison was exactly the womens superfight the PFL had in mind two years ago when the company did its best to sign Cyborg after the legendary MMA champs contract with the UFC expired.

Instead, Cyborg decided to sign with Bellator MMA, presumedly so she could continue feasting on the 145-pound fighters to which shes grown accustomed to beating.

Meanwhile, Harrison went on to grab PFL gold at 155 pounds, as well as that companys $1 million-dollar prize for winning the womens lightweight tournament.

Cyborg vs. Harrison might be a future cross-promotional superfight between two of the biggest MMA superstars in the world today, but its also something that could have happened already.

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Cyborg signed with Bellator MMA in 2019, and the 35-year-old Brazilan went on to capture the womens featherweight championship for that organization.

That made Cybrog the first and only MMA fighter in history to win championships for UFC, Bellator MMA, Invicta FC, and Strikeforce. Its something Cyborg calls a Grand Slam, and shes been lauded by the likes of UFC superstar Conor McGregor and many others for having achieved it.

SoCyborg is considered by most MMA observers to be one of the most accomplished champions in MMA history.

In a combat sports world frequently way too quick to crown fighters as the greatest of all time, Cyborgs long history of excellence is one of the few cases that might actually warrant that kind of consideration.

Still, some have criticized Cyborg for refusing to move up in weight in the past, and sources stated that Cyborgs main contention about joining the PFLs growing roster of talent in 2019 was that she didnt want to face Harrison at 155.

Recently, Cyborg suggested that might no longer be an issue.

I believe this year shes gonna fight for PFL, shes gonna be in a tournament at 155, and if she becomes the champion of this tournament, for sure I would like to make a match with her that all the fans would like to watch, Cyborg told James Lynch on her YouTube channel.

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Cyborg received several lucrative offers back in 2019, but sources say the PFLs offer was very strong.

Regardless, Cyborg ultimately chose Bellator for what PFL president Ray Selfo described back then as competitive and personal reasons.

I think she wanted to stay in the 145-pound division, Sefo said per MMA Junkie.

Indeed, when Cyborg hit free agency after leaving the UFC, Harrison, the PFLs impressive womens lightweight prodigy, issued a bold challenge to Cyborg via TMZ Sports.

Hi Cris, I heard you lost your job, but if youre interested, the PFL has a very special place for you, and its second [place], Harrison told TMZ Sports.

But Cyborg didnt end up accepting the challenge, and Sefo told MMA Junkie after her decision that it was probably because she wanted to stay at featherweight as well as her relationship with Bellator MMA president Scott Coker.

I think she felt a little bit more comfortable because of that past history, said Sefo per MMA Junkie.

Harrison might not yet have the same length of time as a professional MMA fighter under her belt, but the two-time Olympic gold medalist in Judo has already risen to the top of the sport since starting her pro fighting career back in 2018.

The 30-year-old American has consistently stated she desires megafights against the best fighters in the sport, including Cyborg.

Of course, I would love to fight Cyborg, Harrison said per MMA Junkie in 2020. Shes one of the greats. I dont think itll happen before the PFL season, but Ill fight anybody.

Harrisons challenge to Cyborg in 2019 didnt end up getting her the superfight, but she remains hopeful the fight can happen in the future.

Thats the goal, the goal is to become the greatest of all time. But Cyborg is another female superstar legend. Shes a legend of the sport and I would jump at that opportunity, Harrison said per MMA Junkie.

READ NEXT: PFLs Claressa Shields: Does She Know Who the F*** I Am?

Twitter: @Kelsey_McCarson

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Superfight vs. Kayla Harrison Could Have Happened Already - Heavy.com

Break the Lockdown Blues and Create the Night of Your Dreams Without Leaving Your Room – Isolationist Nightclub Simulator Slated for Launch on Steam…

[This unedited press release is made available courtesy of Gamasutra and its partnership with notable game PR-related resource Games Press.]Create your own electronic music, play mini-games or just explore the various rooms of your nightclub in relaxing sandbox experience

Melbourne, Australia -- February 3, 2021 -- If lockdown is driving you stir crazy, escape to your very own nightclub in Isolationist Nightclub Simulator, coming to Steam next month. In a relaxing sandbox-meets-multimedia art experience, you can create, explore or simply relax in the lush vibes of this expansive virtual space all your own.

In a dark, yet all too familiar time, a plague has all but shut down life on Earths surface, driving you to the safety of your very own fallout shelter where you escape into the vivid simulation of a futuristic, neon lit and labyrinthine nightclub. Create your own music (no prior skill required!) using in-game instruments, including a synth keyboard, drum machine, bass loops and arpeggiator, or occupy yourself with an assortment of mini-games in your clubs Arcade. Feel like just relaxing instead? Explore a series of serpentine spaces, such as an art gallery, a forest-scale garden and a number of Chill Out rooms where you can sit back with a virtual drink and relax with soothing music - perhaps of your own making. You can also leave notes for other players with the in-game messaging system, which randomly populates items such as drink coasters or toilet wall graffiti with your messages.

Following on from a project I released last year called Neon Cyborg Cat Club, I felt compelled to create a new world that was much more expansive and interactive, said Edwin Montgomery, Composer and Developer. As we're all spending so much time at home these days, I wanted to build a virtual space that would offer a sense of discovery, play and creation. Isolationist Nightclub Simulator provides an experience that anyone can enter and make their own.

Isolationist Nightclub Simulator is supported by Creative Victorias Sustaining Creative Workers grant and is designed to provide a relaxingly creative experience that offers a little something for everyone, no matter what mood you are in. Isolationist Nightclub Simulator is expected to launch on Steam soon for the price of $5USD with a 10% sale at launch.

About Edwin MontgomeryWith a background in classical composition and a Masters Degree from AFTRS in composing for screen, Edwin Montgomery is a composer, musician and sound designer who works across film, games, immersive theatre, installations and mixed media artworks. Recently they scored the award-winning feature documentary Time, which won Best Documentary Directing at Sundance 2020, and created the cult hit game Sisyphus Reborn, as well as the unique sonic-driven interactive experience Neon Cyborg Cat Club.

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Break the Lockdown Blues and Create the Night of Your Dreams Without Leaving Your Room - Isolationist Nightclub Simulator Slated for Launch on Steam...

Teen Titans: What Happened to Terra in the 2003 Cartoon? | CBR – CBR – Comic Book Resources

An episode of 2003's Teen Titans suggests that Terra could be alive, but she has no interest in rejoining the team.

During the Teen Titans Season 2 finale, "Aftershock Part 2," former member Terra sacrifices herself and defeats the villain Slade,but turns into stone in the process.The character was thought to befrozen until the Season 5 series finale, "Things Change," when Beast Boy comes across a girl who looks exactly like Terra. Although the episode's conclusion doesn't verify whether this girl is Terra,Teen Titans provides a few possibilities on how she came back to life.

Beast Boy first comes across this girl while battling a White Monster alongside the Teen Titans in Jump City. The shapeshifter immediately tells the team about his discovery, butCyborg and Raven explain that they already tried reviving her with their powers without any success. This leads Beast Boy toreturn to the place of her statue, which he finds is missing. Helater discovers thatthe girl from the aforementioned battle is a student at a local high school and persuadesher to eat pizza with him. Unfortunately, their meet-up goes awry when the girl cannot remember any ofTerra's past adventures with the Teen Titans.

RELATED:Teen Titans: Every Team Member Got Their Own Season - Except One

The girlreluctantly agrees to go with Beast Boy to Titans Tower, but while there, she cannot remember any of its details, including her former room.She also denies liking Terra's favorite pizza or enjoying the outdoors. During their time in Terra's old room, she appears to slightly remember a tin heart-shaped box that Beast Boy made, but it causes her instant discomfort, and she asks to leave. Before her departure, Beast Boy throws mud in her face ina last-ditch attempt to trigger her powers, but this simply infuriates the girl who storms off. Beast Boy has one final encounter with the girl at her school,where she tells him that things were never the way he remembered and that the Terra he recalls was just a memory. He eventually accepts that whether the girl is Terra or not, she just wants to live a normal life, and they go their separate ways.

Several of the Teen Titans propose a few theories as to how Terra returned. Robin suggests that Terra freed herself, as she is capable of manipulating the earth and stones. Cyborgstates that an earthquake could've occurred while the team was absent from Jump City. Raven posits the possibilitythat the stone effect simplywore off, then explains that Terra did not return to the group as a result of their final encounter as enemies.While Beast Boysearches for Terra, he comes across a robot named Slade who implies that Terra simply chose to come back without her memory. Although this is possible, Slade is a known manipulator and was likely lying.

RELATED:Teen Titans: Future State Shows How DEADLY a Classic DC Weapon Could Be

Season 4's multi-part finale, "The End," offers a few possibilities regarding Terra's return. During "The End Part 2," Slade reveals that Trigon brought him back to life in return for his servitude,which means that the demon also had the power to revive Terra. The episode also sees the demon turn nearly all of the Earth's inhabitants, except the Teen Titans, into stone. Trigon's ultimate defeat at the hands of Raven during the following episode, "The End Part 3," reversed this action, which could've unfrozen Terra in the process.

The girl Beast Boy comes across shows no interest in crime-fighting, and any memories she had as Terra are likely buried due to her trauma.While it's possible that Terra came back to life, "Things Change" shows that her future does not lie with the Teen Titans.

KEEP READING:Teen Titans Academy Will Recruit Shazam!'s Billy Batson After Future State

Batwoman Teases New Information About Ruby Rose's Kate Kane

Aaron Grech is a writer, cinephile, Nintendo gamer, music addict and television nerd based out of Southern California. A graduate from the University of California, Riverside, Aaron has written for a variety of pop culture websites, where he's covered entertainment industry news, provoking think pieces and event reviews. When he's not busy writing, reading, watching movies or on Twitter, Aaron likes to play Pokmon, Among Us, Super Smash Brothers Ultimate, Fire Emblem Three Houses, Classic Metroid, Animal Crossing, and Civilization 6. His favorite movie directors include Denis Villeneuve, Alejandro Jodorowsky, John Singleton, The Coen Brothers, Wes Anderson, David Cronenberg, Ridley Scott and Guillermo Del Toro.

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Teen Titans: What Happened to Terra in the 2003 Cartoon? | CBR - CBR - Comic Book Resources

I Correctly Guessed The Entire Plot Of The Mass Effect Trilogy From Looking At Ten Screenshots – TheGamer

Today marks the start ofMass Effect Week here at TheGamer. If you're out of the loop, the team has been working tirelessly to bring you interviews, essays, and exclusive behind-the-scenes features to celebrate the upcoming release of Mass Effect: Legendary Edition. We're all very excited to show you what we've got planned this week, after all, Mass Effect is one of the greatest RPG games ever created. Or at least, that's what I'm told. I've never actually played any of the Mass Effect games.

Related:"We Weren't That Smart" - Mass Effect Writer Likes The Indoctrination Theory, But It Was Created By Fans

I am no slouch, however, so when the boss man says "Jump for Massive Effect, Eric" I say "How High, Sir?" I may not know Mass Effect, but I know a lot about plot structure and science fiction stories. What follows is my estimation of who the characters in Mass Effect are and what events unfold throughout the trilogy. As far as I know and I haven't asked a single person these guesses are 100% accurate and correct.

Starting off with the one everyone knows: this is Lt. Colonel John Sheppard, Commander of the SS Omaha. Sheppard is a veteran of the first Galactic Space War and he carries thebattle scars on his heart (and his face). He has a cold-blooded reputation and body count to back it up. Sheppard's "shoot first, ask questions never" attitude has been known to get him into trouble now and again, but his loyal crew of ne'er-do-wells can always be counted on to get him out of a jam. Morally flexible but emotionally rigid, John Sheppardstartsas a cold and distant spaceman with a chip on his shoulder and a big ol' slice, again, on his face. Sheppard eventually learns to be a more caring and compassionate leader. I guess you could say the love of his crew has a "Mass Effect" on him ;).

This is Sheppard's right-hand man, Big Glenn. Sheppard and Glenn fought side by side during the first Galactic Space War. Brothers-in-arms, Big Glenn was Sheppard's first recruit after the war. Big Glenn used to be a normal-looking human man like Sheppard but volunteered himself to be turned intoa hideous rock monster during the war (before the transformation he was known as Glenn). Big Glenn secretly resents Sheppard for looking like a normal man and eventually betrays Sheppard and the crew at the end of Mass Effect 2. Big Glenn later joins up with Sheppard's sworn enemy, Darth Cyborg.

Darth Cyborg is the sworn enemy ofLt. Colonel John Sheppard and the main antagonist throughout all three Mass Effect games. Cyborg and his legion of unmen threatened peace in the galaxy during the first war.When the war ended, Cyborg faked his death and went into hiding, but resurfaced at the beginning of Mass Effectto terrorize Sheppard and his crew throughout the trilogy. Driven by an insatiable lust for revenge, Darth Cyborg will stop at nothing to see Sheppard fall beneath his robot heel. He is voiced by David Schwimmer.

Related:Remembering The Rebel Inside - An Interview With Courtenay Taylor, The Actor Behind Mass Effect 2s Jack

Kortana is Sheppard's love interest and AI companion throughout all three games. After a particularly dangerous space heist, Sheppard is told by his client that he can't pay him the galactic credits he owes him, but offers him Kortana instead. Sheppard and Kortana quickly form a close bond, but given her incorporeal nature, there is an unresolvable barrier that keeps them at a distance. During Mass Effect 2, Sheppard acquires a synthetic body for Kortana so they can finally be together. Unfortunately, the end of Mass Effect 3 reveals that the entire series was just a fantasy created by Kortana so that she could simulate her life together with Sheppard. It's a sad ending, but this is why everyone hates Mass Effect 3.

These are just the Sentinels from The Matrix: Reloaded. Next.

This is Klerg the Pyromaniac. Klerg is a mercenary that Sheppard picks up during the first Mass Effect while investigating Darth Cyborg's whereabouts. Klerg is wanted by the galactic police on ten counts of arson, but unfortunately, Sheppard doesn't know this until the law comes looking for him. Ever the loyal leader, Sheppard distracts the police while Klerg sets their space ship on fire. This cements their bond, and Klerg the Pyromaniac becomes one of Sheppard's most loyal crew members throughout the rest of the series. Klerg can eventually learn pyromancy if you allow him to train at the School of Destruction on the planet Nirn.

This is Sheppard's pet gorpo, Spots. Gorpos are basically space dogs, but they live for 400 years and can speak simple English. Sheppard inherited Spots from Colonel Jacob Sanders, his commander in the space war. Spots is 375 years old and one of the last living beings that can still remember Earth That Was. He often makespop culture references and serves as the comic relief in Mass Effect. His catchphrase is, "What's a gorpo gotta do to get a Bud Light Lime around here?"

Related:Jacob From Mass Effect Was Once Romanceable For Male Shepard In "Brokeback Mountain" Cutscene

Anexistential threat to the galaxy is introduced in Mass Effect 2. After being defeated by Sheppard and his crew in the first game, Darth Cyborg develops a parasite that spreads to all plant life throughout the galaxy. Left unchecked, the parasite attaches itself to the space flora and quickly transforms it into strange, shimmering creatures. At first, Sheppard and his crew don't understand what is happening to the space trees, which are uprooting themselves and attacking people all across the galaxy. He eventually traces the parasite back to Darth Cyborg and forces him to hand over the anti-parasite, rescuing the galaxy from certain doom.

These are Darth Cyborg's unmen, created at the end of Mass Effect 2 when Cyborg's parasite mixes with ultra-violent light (light created from two stars smashing into each other) and infects a human host. The unmen are fierce warriors that crave death and destruction. Darth Cyborg turns them loose on an unsuspecting galaxy in Mass Effect 3 and leads them in the second Galactic Space War, with Sheppard and his crew leading the resistance. The unmen are eventually defeated as all villains are with the power of love.

The Power of Love is a kick-ass laser beam capable of absolutely obliterating Darth Cyborg and his legion of unmen. Built-in secret by an ancient race of highly-advanced aliens called the Chozones, The Power of Love serves as the home base for Sheppard and his crew throughout most of Mass Effect 3. In the end, the heroes discover that the only thing that can power the Power of Love is Kortana. She sacrifices herself to defeat Darth Cyborg once and for all and save the galaxy. This would have been a powerful moment, but of course, it's then revealed the entire trilogy was a dream sequence/simulation in Kortana's artificial mind. Everyone hates this ending.

There you go, my 100% accurate and true summary of the Mass Effect trilogy, I think.

If you'd like to read more aboutMass Effect from the people that actually made the game, check out this interview with Courtenay Taylor, who plays Jack in Mass Effect 2. If you're interested in how Mass Effect 3 could have ended differently, read our interview with writer Chris Hepler. We've got more great articles about Mass Effect coming all week long. Stay tuned.

Next:Mass Effect 3 Could Have Had A Completely Different Ending

CDPR Puts A Stop To People Getting It On With Keanu Reeves In Cyberpunk 2077

Eric Switzer is the Livestream News Editor for TheGamer as well as the lead for VR and Tech. He has written about comics and film for Bloody Disgusting and VFXwire. He is a graduate of University of Missouri - Columbia and Vancouver Film School. Eric loves board games, fan conventions, new technology, and his sweet sweet kitties Bruce and Babs. Favorite games include Destiny 2, Kingdom Hearts, Super Metroid, and Prey...but mostly Prey. His favorite Pokmon is Umbreon.

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I Correctly Guessed The Entire Plot Of The Mass Effect Trilogy From Looking At Ten Screenshots - TheGamer

”The Nevers” to premiere on HBO in April – Outlook India

Los Angeles, Feb 3 (PTI) "The Nevers", a sci-fi period drama created by Joss Whedon, will air on HBO in April, the premium cable network has announced.

HBO released a teaser trailer of the show on Tuesday night that gave a glimpse into "The Nevers", which revolves around a gang of Victorian women who find themselves with unusual abilities, relentless enemies, and a mission that might change the world.

According to The Hollywood Reporter, Whedon exited the show in late November citing "the physical challenges of making such a huge show during a global pandemic".

Screenwriter Philippa Goslett, known for her work in films like "Mary Magdalene" and "How to Talk to Girls at Parties", took over showrunner duties from Whedon last week.

Led by Laura Donnelly, Ann Skelley, Olivia Williams and Nick Frost, the cast of the show also includes Kiran Sonia Sawar, Elizabeth Berrington, Ella Smith, Viola Prettejohn, Anna Devlin and Martyn Ford.

The six episodes HBO will debut in the spring were filmed before Whedon''s departure.

The remainder of the first season, under Goslett, will follow at a later time.

Whedon and producers Geoff Johns and Jon Berg were under investigation by WarnerMedia, HBO''s parent company, over allegations of misconduct on the set of "Justice League" made by star Ray Fisher, who starred as Victor Stone alias Cyborg in the DC comicbook film adaptations.

Late December last year, WarnerMedia said the company had concluded the investigation and "remedial action" had been taken, without elaborating what it entailed.

Whedon stepped in for Zach Snyder on the 2017 superhero project after the latter exited the film in the wake of a family tragedy.

When the completion of the probe was announced by WarnerMedia, Fisher said he will not be part of any project associated with DC Films President Walter Hamada, whom the actor earlier called "most dangerous kind of enabler".

In January, Fisher confirmed he had received official confirmation that studio Warner Bros has decided to "remove" him from the cast of their upcoming superhero movie "The Flash".

In his previous posts, the actor has accused Hamada of protecting Johns and Whedon by hampering the studio''s investigation into his allegations.

Hamada became president of DC Films in 2018, after "Justice League" opened in theatres to poor reviews and box office records.

However, Fisher maintains Hamada has failed to take his claims seriously about the Whedon-led reshoots of "Justice League". PTI RDSRDS

Disclaimer :- This story has not been edited by Outlook staff and is auto-generated from news agency feeds. Source: PTI

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''The Nevers'' to premiere on HBO in April - Outlook India

Claressa Shields open to Katie Taylor fight but says she is already greatest female boxer of all time – DAZN News US

Claressa Shields has responded positively to recent quotes from Katie Taylor that indicated she would love to one day challenge her fellow undefeated women's boxing icon, despite the gap in weight classes.

Taylor has made it known that she would like to make as many big-name fights happen as possible before she ends her career, including against the likes of Jessica McCaskill, Cecila Braekhus, Shields herself and even MMA star Cris Cyborg.

If Taylor vs. Shields were to happen today, it would pit the current undisputed lightweight champion against the former undisputed and now unified middleweight champion. The Irish fighter says she could go as high as welterweight to make it happen.However, that is still quite the weight-cut for the American, who hasn't made 147lbsince she was 16 years old.

"I would go to 147lbs for a fight with Katie Taylor,"Shields told Metro.co.uk. "I was willing to go to 147 for a fight against Cecilia Braekhus, and I will still go to 147 to fight Jessica McCaskill. But my thing is, 'If you want me to come to 147, you have to pay me to come to 147'.My highest purse is $350k, so to go down to that weight, I would like to be paid the right way and given a fair shot. I think a lot of these fighters want me to come to 147 and not rehydrate, but that's not good for any fighter.I think a fight between me and her, me not rehydrating back up to 160, is fair because she is coming up from a smaller weight class. But don't say I can't rehydrate past 150lbs. That's unfair. Somewhere from 154-158 would be fair."

Shields cited her past experiences with trying to negotiate with a welterweight and how unjust the expectations were.

"I had discussions with Cecilia Braekhus and her team, but they want no parts of me," Shields said."They were saying, 'Yeah, we'll fight at 147, but you can't rehydrate past 150lbs'. 'I was like, "are y'all crazy?"

"For one, I would still whoop her ass if that happened, but I care about how I perform and displaying my best skill set in every fight.I'm not going to go in there looking all tired and sluggish. I'll still win, but I want to be able to watch my film and think, "I did great."

Shields also believes that whatever happens between her and Taylor in the future, she is already well ahead of Katie in the 'greatest female boxer ever' stakes and can not be caught.

"To me, there is no debate, to be honest,"Shields said."I feel like that is me, period.I have a lot of respect for Katie Taylor, and I feel like it really depends what you like inside the ring. Do you like somebody that moves around, and you like people to have competitive fights?Kind of like the fight between Katie Taylor and Delfine Persoon. You will never see me in a fight that close. But I think some people look at that as a plus and it makes them like a fighter more.

"(People say) 'Oh, she got in a war, she won close fights.'Then you watch me go in there with some of the best fighters, and I make them look average, and even though you can say, 'I'm the better fighter'. But people like to know that fighters have vulnerabilities and I haven't shown any vulnerabilities except the fight against [Hanna] Gabriels.She knocked me down in the first round, but when I got back up, it was all hell to pay for her, and I won a unanimous decision. I think in terms of skills and everything we can do inside the ring that I'm definitely the pound-for-pound greatest woman of all time. But those who say Katie Taylor, I don't get mad, I disagree, but that's just their flavour."

Shields next steps into the boxing ring on March 5 in her hometown of Flint, Michigan, against Canada'sMarie-Eve Dicaire, but will also make her professional MMA debut later in the year.

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Claressa Shields open to Katie Taylor fight but says she is already greatest female boxer of all time - DAZN News US

10 Anime To If You Love Cyberpunk 2077 – TheGamer

Cyberpunk 2077 is a decent entry into the niche that is cyberpunk which the world isn't quite ready for just yet. Its release marks an important milestone in the said media genre as there aren't as many cyberpunk gamesin that class of popularity. Sadly, the release was marred by bugs and performance issues and the game was also rather short. It was short enough to leave playerscraving more cyberpunk adventures.

RELATED:Every Difference Between The PS5 & Xbox Series X Version Of Cyberpunk 2077

But some fans might want to take a break from cyberpunk games with other media in the genre. It just so happens that nothing else explains cyberpunk better than anime because Japan essentially fueled the cyberpunk golden age.

So breathe in that high-tech poverty and crime dystopia with these iconic cyberpunk anime. They ought to fill in the void left by Cyberpunk 2077.

No one canmention cyberpunk without giving a nod to this one. Ghost in the Shell is quite possibly the most important cyberpunk anime in existence as it served as the creative fuel for the Wachowskisiblings when they conceived the Matrix films.

There are many iterations within the Ghost in the Shell family to enjoy such as Stand Alone Complex with characters pictured above.The original film isby far the most philosophical of the bunch and explores the idea of an AI becoming a thinking individual with its own morals. At the heart of that is Major Motoko Kusanagi, a cyborg whose memories are the only human part of heror ghosts in a shell, if you will.

Ergo Proxy is another anime with a female protagonist and a deep plot about the nature of humanity. It explores a world that is still reeling from a recent apocalyptic event. One last bastion of human civilization is all that's left in the world. In order to make their lives and survival easier, special androids were created.

RELATED:10 Games Being Released In 2021 That We Hope Dont Flop Like Cyberpunk 2077

In the anime's current timeline, however, the said androids started exhibiting human behavior and asking questions that not many humans would want to answer. It's up to the androids and humans to investigate the root of such matters before things spiral out of control.

Bubblegum Crisis assumes the typical premise of most cyberpunk worlds. It imagines a Japan that was devastated by a huge Earthquake; this ruined much of society with extreme povertyon top of the physical damage.Furthermore, an evil corporation is producing mechanical monsters that are too much for the police to handle.

So along came the Knight Sabers to set things straight and to fix the problems that the corrupt and evil corporations started. They also do it in style as most of their members are pretty, young, and stylish female powerhouses that commandeer special armor to combat the mechanical beasts.

Psycho-Pass is also more popularly known as the anime version of Minority Report. The whole anime revolves around the so-called Sibyl System that predicts criminal behavior in individuals before they commit crimes. The idea originates from asci-fi novella by Philip K. Dick of the same name as the movie.

RELATED:Cyberpunk 2077: 5 Best Areas Of Night City (& 5 Not To Bother With)

Such a setup is ripe for suspenseful detective opportunities and that's where most of Psycho-Pass's story lives. Much like most cop stories, this one involves an idealistic rookie and her veteran partner who's one case away from becoming a disillusioned outcast.

Iffans don't mind going a bit further in the future, then Battle Angel Alita offers a grim and unsettling dystopia where the poor live amongst the rich's trash heap. After watching this one,people can also treat themselves to a live-action Hollywood adaptation. The film, called Alita Battle Angel, released in 2019.

They pretty much have the same story and narrative nearly shot-for-shot. Both films begin with a cyborg doctor discovering Alita's mangled remains in a garbage dump. Pretty soon, he discovers that Alita is more than just an old cyborg and has a past that makes her a deadly individual.

Much like Ghost in the Shell, Akira is also a significant film for the cyberpunk genre. It was first released back in 1988 and even by today's standards, it puts many other anime to shame with its fluid hand-drawn visuals.

RELATED:Cyberpunk 2077: The Best & Worst Things About Each Romance

The story itself is also riveting as it follows the struggle of a biker gang where one of their friendswas unfortunate enough to be an accidental vessel for an entity that can warp reality. Amidst all that, a riot is also ensuing against the government which presumably prioritizes experiments instead of the welfare of their people.

Texhnolyze toys around with one of the cyberpunk genre's most ubiquitous trademarks: cybernetics. The idea that people can discard their organic parts and become functionally immortal or something stronger, faster, and smarter is one of the points of conflict in the genreas Cyberpunk 2077 exhibited. Texhnolyze further showcases this idea.

This notion is seen in action through the eyes of an unfortunate prizefighter who lost some of his limbs due to "occupational hazards." He was, however, chosen as a candidate for an experimental limb tech called Texhnolyze.

A cyborg with a giant revolver for a head is not somethingpeoplewould expect in a cyberpunk setting but this is anime, so No Guns Life is about as valid as it is outrageous. That cyborg is also the main character of the show and has a trench coat that puts all noir detectives to shame.

RELATED:10 Cyberpunk 2077 Legendary Items You Need

He was created as a special kind of weapon to fight in a war. Is anyone getting Master Chief vibes here? The catch is that he has no memories of his pre-war life but life goes on anyway. He decided to become a private investigator who solves crimes related to cyborgs similar to him.

This kind of animation might put some people off, but Blame! is a solid cyberpunk film and six-episode series. The story takes place in an entirely automated world in a time far more technologically advanced than now. An infection takes hold of the automated systems and the city begins to go haywire.

Without getting too spoiler-y, the basic plot is a team is deployed to fix The Problem. The team including Killy the Wanderer must evade the Safeguard -- a rampant defense system purging humans. Pop the popcorn, grab your favorite beverage, and settle in for some classic cyberpunk action.

Serial Experiments Lain mostly focuses on the intellectual side of cyberpunk and as such, it tackles an issue more convoluted than Cyberpunk 2077's proto-immortality corpo-war angle. The protagonist Lain suddenly stumbles upon a cyberspace not unlike our internet today.

Only, the cyberspace she opened is more dangerous and reality-altering. Serial Experiments Lain shows its viewers the dangers of false identities forged in a digital world in what appears to be a cyberpunk setting at its infancy.

NEXT:Cyberpunk 2077: Every District, Ranked From Worst To Best

Next Pokemon: The Strongest Type Expert Of Every Type

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10 Anime To If You Love Cyberpunk 2077 - TheGamer

Blu-ray TV reviews: ‘Snowpiercer’ and ‘Doom Patrol’ – Washington Times

Heres a look at a pair of excellent episodic shows from Warner Bros. Home Entertainment now available in the Blu-ray format.

Snowpiercer: The Complete First Season (Rated: TV-MA, 1.78:1 aspect ratio, 440 minutes, $29.98) TNTs popular post-apocalyptic, sci-fi series debuts on the Blu-ray format to offer bingers a chance to catch up on the first 10 episodes of the show before diving into the currently broadcast second season.

Reimagined from director Bong Joon-hos 2013 movie and the 1982 French graphic novel, the show offers an adventure in class warfare in the most claustrophobic way possible.

Specifically, well-meaning scientists accidentally unleash an ice age as they tried to curb the heating of the planet setting off an extinction event.

Luckily, mysterious billionaire Wilford builds a train with a perpetual-motion engine to circle the planet and keep only the most-deserving and wealthy of humans alive.

That translates into 3,000 survivors stuck on a 10-mile-long, 1,001-car train divided by classes first (for high-priced, paid passengers); second and third classes (for those with specialized skill sets to keep the train running and passengers fed); and a final group who illegally hijacked some of the rear cars of the train.

Led by Andre Layton (Daveed Diggs) and disrespectfully called tailers, they are treated with disdain and nearly slave status by the other passengers. Of course, Layton and his rebel survivors want more and hatch a plot to take control of the Snowpiercer.

A wrinkle to the plan occurs when Head of Hospitality Melanie Cavill (Jennifer Connelly) asks Layton to come up the train and wear his former Detroit homicide detective hat to solve a series of murders.

They form a bond that will ultimately decide the fate of humanity as well as reveal who is really in charge of the Snowpiercer.

I defy any viewer to not often bite their fingernails to the nub after watching what starts out as a dystopian version of Murder on the Orient Express and eventually evolves into a graphically violent and bloody expose on a class revolution.

Suffice it to report, sci-fi junkies, its time to board the Snowpiercer.

Best extras: A collection of four promotional featurettes (roughly 12 minutes total) offer the barest of surface information about the series with talking head gushing from crew and cast including director James Hawes, showrunner Graeme Manson, Miss Connelly and Mr. Diggs.

Only a six-minute look at some of the key train cars (first-class dining, night car, classroom and the drawers for example) explored by production designer Barry Robison delivers some meaty background for new fans.

The extras should have been so much more. An optional commentary track on any of the episodes would have been nice or, better yet, a look at the adaptation of the series based on the original source material.

Doom Patrol: The Complete Second Season (Not rated, 2.20:1 aspect ratio, 405 minutes, $39.99) HBO Max continued the mature, live-action adventures of DC Comics strangest superhero team adapted from their 1960s comic book roots as well as writer Grant Morrisons updated group from the late 1980s.

The latest nine episodes of the show arrives via a pair of Blu-ray discs returning viewers to the Victorian-styled Doom Manor where they are reacquainted with former actress Rita Farr aka Elasti-Girl (April Bowlby); former NASCAR driver Cliff Steele aka Robotman (Brendan Fraser); former experimental aircraft pilot Larry Trainor aka Negative Man (Matt Bomer); Kay Challis aka multiple personality-loaded Crazy Jane (Diane Guerrero); Vic Stone aka Teen Titans Cyborg (Joivan Wade); and wheelchair-bound leader Dr. Niles Caulder aka Chief (Timothy Dalton).

The show thrives on simmering side plots that reveal the origins of the tragic Doom Patrol members as well as pitting them against some incredible villains.

This season, we learned about Chiefs mysterious daughter, the primate-faced Dorothy Spinner (Abigail Shapiro) and her monstrous imaginary friends now living with her in the mansion, Larry Trainors remaining family after he attends his 60-year-old sons funeral and the horrors of Miss Farrs childhood living with a showbiz mother.

Visually impressive, guest star villains, authentic from the comics, appear en masse to vex the Doom Patrol including interdimensional sadist Red Jack; premier time manipulator Dr. Tyme; the sex demon Shadowy Mr. Evans; and the star enemy of the season, the super-powered ancient deity Candlemaker, unleashed by Chiefs daughter.

And developers make sure to throw in even more comic book characters to thrill fans ranging from the return of heroic body builder Flex Mentallo to an introduction to space-traveling Pioneers of the Uncharted team member Valentina Vostok and even the Sex Men, a group of paranormal sexual phenomenon investigators who arrive to stop Shadowy Mr. Evans.

Yeah, the Sex Men really did show up in DCs sequential art, specifically Doom Patrol No. 48 way back in 1991.

The show also loves to embrace pop culture chaos demonstrated in the irreverent fantasy sequence where Cyborg and Robotman appear in a 1970s cop show Steel and Stone, or the group throwing a 1980s disco party to restore a sentient, teleporting entity Danny, currently in the form of a shattered brick.

However, most tragic to the Doom Patrol was the pandemic-shortened season, down from the 15 episodes of the first season.

It not only forced writers to lose one episode of the slated 10-episode story arc, but fans must wait for a third season to further appreciate one of the best, albeit odd superhero shows on any broadcast or streaming mediums.

Best extras: Tragedy abounds with the pathetic selection of bonus content with viewers only get nine minutes on the impressive make-up and visual effects design and two minutes on shooting locations.

Extras for the first season set were just as miserable, and it would be great if next seasons set offered a definitive retrospective on the Doom Patrols origins or the occasional optional commentary track to enlighten viewers to some of the more complex stories.

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Blu-ray TV reviews: 'Snowpiercer' and 'Doom Patrol' - Washington Times

Bioinformatics Services Market | Know the Latest Innovations and Future Market Scope – BioSpace

Bioinformatics is the field mainly involving molecular biology, genetics, mathematics, statistics, and computer science. The bioinformatics services include analysis of the data that can range from processing sequencing reads from instrument to data aggregation and mining data samples. Bioinformatics services can help biologists to understand the biological process with a computational intensive technique for machine learning algorithms, pattern recognition, data mining and visualization.

Bioinformatics tools can help to compare genomic and genetic data and understand evolutionary aspects of molecular biology. Bioinformatics services are finding wide application in chemoinformatics, genomics, metabolomics, RNA-seq analysis, and drug design. The database is an important part for bioinformatics research and application to cover various information types including molecular structure, protein and DNA sequences, and phenotypes in bioinformatics services.

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Bioinformatics Services Market: Notable Highlights

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Some of the most prominent competitors operating in the competitive landscape of global bioinformatics services market include

Bioinformatics Services Market Dynamics

Bioinformatics Services Finding Wide Application in Personalized Medicine Discovery

With the increasing prevalence of various diseases, new treatments and drugs are being discovered and developed. Extensive molecular biological data on patients is being included on a large scale in diagnosis and treatment. Bioinformatics services is fundamental to precision medicine as developing personalized medicine depends on accessing genetic and molecular data. In recent years, the majority of the molecularly targeted drugs have been developed based on the detected gene mutation.

Next-gen sequencing in bioinformatics services is emerging as an important tool in genomic analysis and developing personalized medicine. Next-gen sequencing along with microarrays in bioinformatics services have also paved the way for precision medicine in oncology. Meanwhile, increasing availability and decreasing the cost of next-gen sequencing is allowing worldwide cancer centers to offer next-gen sequencing based personalized oncology for clinical practice while suggesting specific medicine and treatment.

Increasing Initiatives by Governments and Private Organizations in Bioinformatics Services

With increasing application of new technologies in life science, governments and organizations across various countries are investing in the new technologies and in research and development activities in bioinformatics services. According to the Global Alliance for Genomics and Health (GA4GH), around 60 million genomes are likely to be sequenced by 2025. Moreover, with the presence of national clinical genomic initiatives worldwide, the generation of genomic data in healthcare is expected to outpace that in research in the coming years. Governments across countries are increasingly investing in the biotechnology and bioinformatics services to effectively implement new technologies and support genomic and epidemiological research.

Countries such as the US, UK, Australia, France, Japan, Saudi Arabia, Qatar, Denmark are developing new strategies for projects focusing on cancer and rare diseases, along with the use of sequencing services and genomic data. New research activities are also being conducted for application of bioinformatics services in biodefense. The Mid-Atlantic Microbiome Meet-up (M3) is focusing on the use of next-generation sequencing technologies and recent advances in biodefense, especially related to infectious diseases, and also using metagenomic methods for detection.

Shortage of Skilled Workforce and High Cost Hampering the Bioinformatics Services Market Growth

Although bioinformatics services is emerging as an important part of research in life science, lack of skills and knowledge in bioinformatics is hindering its growth. With the technological and process advancements in biotechnology, it has become imperative that bioinformatics techniques are performed by skilled personnel. However, the need for heavy investment in tool upgradation and installation training is impeding the growth of bioinformatics services. Owing to this there is a lack of skilled manpower in bioinformatics services who can adapt to the high-end bioinformatics techniques and processes.

Moreover, the lack of skilled professionals in bioinformatics services is also hampering the growth of clinical laboratories as they are focusing to automate processes. However, in recent years, governments along with healthcare institutions are focusing on strategies to provide new courses in bioinformatics as it holds a big promise in solving many health related and environmental issues.

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Bioinformatics Services Market Segmentation

Based on the type, the bioinformatics services market is segmented into

On the basis of application, the bioinformatics services market segment includes

Based on the specialty, the bioinformatics services market is segmented into

Based on the end-user, the bioinformatics services market segment includes

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Bioinformatics Services Market | Know the Latest Innovations and Future Market Scope - BioSpace

Adjuvant platinum-based chemotherapy in non-small cell lung cancer: The role of relative dose-intensity and treatment delay. – Physician’s Weekly

The study investigated the association of the relative dose-intensity (RDI) of cisplatin and timing of adjuvant platinum-based chemotherapy (APC) with survival for stage I-III non-small cell lung cancer (NSCLC) patients.Real-life data of patients treated with APC (four cycles of cisplatin and vinorelbine) between 2007 and 2014 was included to analyse the association between disease-free survival (DFS) and overall survival (OS) with RDI (ratio of received to planned dose-intensity). High RDI was defined as cisplatin RDI of > 75% and low RDI 75%.Out of 198 patients, 166 were eligible. Low RDI was administered to 72 (43%) patients. In multivariate analysis, those patients had a significantly higher risk of recurrence (HR: 1.87, 95%CI 1.13-3.09, p=0.01) and death (HR: 1.91, 95%CI 1.32-3.23, p=0.01) versus patients in the high RDI group. The risk of death was significantly higher in patients with PS 1 treated with low versus high RDI (HR: 2.72, 95%CI: 1.22-6.09, p=0.014). The risk of recurrence was higher for patients with squamous cell carcinoma of low versus high RDI (HR: 3.82, 95%CI: 1.01-14.4, p=0.048). No impact of delayed APC beyond six weeks from surgery on neither DFS (HR: 0.78, 95%CI: 0.46-1.33, p=0.36) nor OS (HR 0.67, 95%CI: 0.40-1.15, p=0.15) was observed.Low cisplatin RDI 75% of APC, but not extended time from surgery to APC onset > six weeks, was associated with significantly shorter survival in NSCLC patients.

PubMed

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Adjuvant platinum-based chemotherapy in non-small cell lung cancer: The role of relative dose-intensity and treatment delay. - Physician's Weekly

Syngenta Crop Protection and Insilico Medicine to Harness Artificial Intelligence to Transform Sustainable Product Innovation – Business Wire

BASEL, Switzerland--(BUSINESS WIRE)--Syngenta Crop Protection is collaborating with artificial intelligence (AI) and deep learning company Insilico Medicine to accelerate the invention and development of new, more effective crop protection solutions that protect crops from diseases, weeds and pests, while also protecting ecosystems. By bringing new solutions to farmers faster and more efficiently through innovation, Syngenta will help them meet the ongoing challenges they face, in order to enhance productivity and meet global demand for affordable, quality food.

This collaboration with Insilico Medicine means that Syngenta can harness the immense potential and scope of AI to develop the next generation of sustainable crop protection solutions as part of Syngentas $2bn commitment to innovation and sustainability, said Camilla Corsi, Head Crop Protection Research at Syngenta. This will further transform agriculture by providing farmers around the world with the tools they need to produce healthy, nutritious, affordable and sustainably grown food in the most efficient way, while also minimizing the environmental impact.

Insilico Medicine has a proven track record and has delivered significant advances in pharmaceutical research, using AI and deep learning to design, synthesize and validate new ingredients. The same approach also has the potential to transform the development of new crop protection solutions that help keep plants safe, from planting to harvesting. Working closely with Syngenta, Insilico Medicine will use their AI-powered small molecule generative chemistry technology not only to invent molecules for active ingredients faster, but also actively design molecules that are more sustainable and environmentally friendly.

We are very happy to collaborate with a company that is dedicated to developing safe and sustainable solutions for growers, said Alex Zhavoronkov, PhD, founder, and CEO, Insilico Medicine. Our artificial intelligence is designed from the ground up to produce very precise chemistry to protect human health, while ensuring short-term and long-term safety. This expertise is extremely valuable for crop sciences, and especially so for businesses whose top priority is the safety of their products. Syngenta is a progressive company with many brilliant scientists, and we will be working together to use artificial intelligence for the benefit of agriculture.

Our reputation as a global leader in innovation is built on a foundation of collaboration and our understanding of the challenges faced by growers, Camilla Corsi also noted. Working together with Insilico Medicine, combining our skills, knowledge and technologies, will help ensure that new and more effective crop protection solutions will be in the hands of farmers sooner.

About Syngenta

Syngenta is one of the worlds leading agriculture companies, comprising of Syngenta Crop Protection and Syngenta Seeds. Our ambition is to help safely feed the world while taking care of the planet. We aim to improve the sustainability, quality and safety of agriculture with world class science and innovative crop solutions. Our technologies enable millions of farmers around the world to make better use of limited agricultural resources. Syngenta Crop Protection and Syngenta Seeds are part of Syngenta Group with 49,000 people in more than 100 countries and is working to transform how crops are grown. Through partnerships, collaboration and The Good Growth Plan we are committed to accelerating innovation for farmers and nature, striving for carbon neutral agriculture, helping people stay safe and healthy and partnering for impact.

To learn more visit http://www.syngenta.com and http://www.goodgrowthplan.com

Follow us on Twitter at http://www.twitter.com/Syngenta and http://www.twitter.com/SyngentaUS

About Insilico Medicine

Insilico Medicine develops software that leverages generative models, reinforcement learning (RL), and other modern machine learning techniques for the generation of new molecular structures with specific properties. Insilico Medicine also develops software for the generation of synthetic biological data, target identification, and the prediction of clinical trials outcomes. The company integrates two business models; providing AI-powered drug discovery services and software through its Pharma.AI platform (www.insilico.com/platform/) and developing its own pipeline of preclinical programs. The preclinical program is the result of pursuing novel drug targets and novel molecules discovered through its platforms. Since its inception in 2014, Insilico Medicine has raised over $52 million and received multiple industry awards. Insilico Medicine has also published over 100 peer-reviewed papers and has applied for over 25 patents. Website http://insilico.com/

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Cautionary Statement Regarding Forward-Looking Statements

This document may contain forward-looking statements, which can be identified by terminology such as expect, would, will, potential, plans, prospects, estimated, aiming, on track and similar expressions. Such statements may be subject to risks and uncertainties that could cause the actual results to differ materially from these statements. For Syngenta, such risks and uncertainties include risks relating to legal proceedings, regulatory approvals, new product development, increasing competition, customer credit risk, general economic and market conditions, compliance and remediation, intellectual property rights, implementation of organizational changes, impairment of intangible assets, consumer perceptions of genetically modified crops and organisms or crop protection chemicals, climatic variations, fluctuations in exchange rates and/or commodity prices, single source supply arrangements, political uncertainty, natural disasters, and breaches of data security or other disruptions of information technology. Syngenta assumes no obligation to update forward-looking statements to reflect actual results, changed assumptions or other factors.

2021 Syngenta. Rosentalstrasse 67, 4002 Basel, Switzerland. The Syngenta logo are trademarks of a Syngenta Group Company. All other trademarks are the property of their respective owners.

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Syngenta Crop Protection and Insilico Medicine to Harness Artificial Intelligence to Transform Sustainable Product Innovation - Business Wire

M6P Therapeutics Announces Formation of Distinguished, Experienced Scientific Advisory Board – BioSpace

Feb. 3, 2021 12:30 UTC

ST. LOUIS--(BUSINESS WIRE)-- M6P Therapeutics, a privately held life sciences company developing next-generation recombinant enzyme and gene therapies for lysosomal storage disorders (LSDs), today announced its scientific advisory board (SAB) that will support the Companys mission of translating its innovative bicistronic-S1S3 technology platform into best-in-class therapies that address unmet needs within the LSD community. The Companys platform enables improved biodistribution of recombinant enzymes to target tissues and efficient cross-correction for gene therapies.

As we work to advance our robust pipeline, we seek the input and support of a world-class team of scientific advisors with deep expertise in genetics, rare diseases, and lysosomal storage and metabolic disorders in particular, said Pawel Krysiak, president and chief executive officer of M6P Therapeutics. The collective insights, knowledge, commitment, and expertise of our scientific advisory board will help us translate this high science into potential medical benefit for the individuals affected by these serious conditions.

By combining the substantial expertise of the SAB with the expertise of the Companys internal R&D team in recombinant enzyme and gene therapies, M6P Therapeutics is well positioned to rapidly advance its deep pipeline of LSD programs. The members of the SAB are:

M6P Therapeutics bicistronic-S1S3 technology platform enhances mannose 6-phosphate content on lysosomal enzymes for both recombinant enzyme and gene therapies, which improves enzyme uptake across target tissues, said Stuart Kornfeld, MD, M6P Therapeutics co-founder and chairman of its SAB. With promising pre-clinical data across numerous LSD programs, this innovation can potentially translate into new and more efficacious treatments, reduced immunogenicity, and more efficient dosing regimens.

About M6P Therapeutics

M6P Therapeutics is a privately held, venture-backed biotechnology company developing the next-generation targeted recombinant enzyme and gene therapies for lysosomal storage disorders (LSDs). M6P Therapeutics proprietary bicistronic-S1S3 platform has the unique ability to enhance phosphorylation of lysosomal enzymes for both enzyme replacement and gene therapies leading to improved biodistribution and cellular uptake of recombinant proteins and efficient cross-correction of gene therapy product. This can potentially lead to more efficacious treatments with lower therapy burden, as well as new therapies for currently untreated diseases. M6P Therapeutics team, proven in rare diseases drug development and commercialization, is dedicated to fulfilling the promise of recombinant enzyme and gene therapies by harnessing the power of protein phosphorylation using its bicistronic-S1S3 platform. M6P Therapeutics mission is to translate advanced science into best-in-class therapies that address unmet needs within the LSD community. For more information, please visit: http://www.m6ptherapeutics.com.

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M6P Therapeutics Announces Formation of Distinguished, Experienced Scientific Advisory Board - BioSpace

Experts speak the plain truth about COVID-19 vaccine – Wellington Advertiser

WELLINGTON COUNTY The information about COVID-19 and now the vaccines to fight it has been coming fast and furious over the past year. Its no wonder people are overwhelmed with information and confused about who to trust.

Thats why the Canada Institute of Health Research (CIHR) launched a media blitz in January: to address misinformation and dispel myths head-on.

Dr. Charu Kaushic is the scientific director of the Canadian Institute of Infections and Immunity for the CIHR and a professor of molecular medicine at McMaster University.

In a broad-ranging interview with the Advertiser on Jan. 28, Kaushic answered the most-asked questions and countered some oft-held myths surrounding the vaccines.

Kaushic explained that the COVID-19 vaccines work differently than the vaccines people are accustomed to.

Traditional vaccines take a weakened or inactivated form of a virus and inject it into the body to trigger an immune response.

The new vaccines, called mRNA vaccines, take genetic information from the virus the spike protein and that is injected into the body.

The cells make the protein, they are seen as foreign, and that triggers the immune response, Kaushic said.

Its the immune response that produces antibodies, and its antibodies that protect recipients from getting infected when the real virus comes along. And since only part of the protein is made, it does not do any harm to the person vaccinated.

Once youve had two doses of the Pfizer or Moderna vaccines, you are 95% protected, Kaushic said.

Ninety-five per cent is not 100% but thats the protection. Between the first and second dose, you are not 95% protected. Thats why we still need to exercise precautions, she said.

The mRNA vaccines may be new to laypeople, but researchers have been working on the technology for at least a decade, Kaushic said.

For a long time (researchers) have anticipated there would be a pandemic and they have been preparing since 2017 for making a pandemic vaccine, she said.

When the pandemic started, researchers took the virus, used the technology, and started trials, and the first trials generated good results.

Kaushic said initial trials included 30,000 people aged 18 to 65 as well as those over 80.

Trials are ongoing now for younger age groups, pregnant women and people with underlying health conditions.

We expect to know more (about these groups) in three to four months, she said.

Kaushic said because the vaccine is a world-wide priority and governments have a lot of money on the table to have the vaccine manufactured and distributed, normal timelines have been compressed.

Personnel have been redeployed to vaccine production and its all hands on deck.

The work has been compressed at a cost to governments, but theres no compromise on safety, she said.

Kaushic said she hasnt heard of any deaths as a result of the vaccine and allergic reactions are rare.

In terms of side effects, some people feel nauseated and feverish after receiving the vaccine but that only lasts a day or two.

Kaushic said there is a host of good information out there about the virus, the vaccines, and health protection measures, and listed the World Health Organization, Health Canada and the Centres for Disease Control and Prevention as appropriate places to start.

People should not be getting their news from Facebook, she said.

Get information from people who know what they are talking about. So ask your doctor or health specialist. Check authoritative articles.

Its important to get the right information and its incumbent on people to make sure they check their sources.

Dr. Julie Ray, a family physician at the Upper Grand Family Health Team, in Elora, said her patients are anxious about the vaccine too, although most are eager to get it.

The biggest question is when do I get it and where do I get it? she said. And my biggest answer is I dont know yet.

The second question: is it safe?

Its not so much misinformation, but reservations about how quickly things have progressed, Ray said.

I personally havent had that many conversations that go that way. Most are saying Sign me up, or put me on a list.

Ray said scientists believe there will be herd immunity when approximately 70 per cent of the population is vaccinated.

The idea is if I get sick with COVID, there needs to be enough people immune to it so I cant get them sick and spread it, she said.

Right now, the vaccine is not approved by Health Canada for children, pregnant women or people who with certain underlying health conditions, but trials are ongoing, and that information will change when results are known.

Ray said people who fall in that category should talk to their healthcare provider.

You can get the vaccine if its deemed appropriate. Doctors will discuss it on a case-by-case basis, assessing the riskbenefit in each case, she said.

Ray added family doctors will be part of the broad plan to administer the vaccine, but long-term care residents and front-line healthcare workers are the priority right now.

With news of supply-chain issues for distribution of the vaccine, previous timelines are now out the window.

But that doesnt mean you shouldnt be prepared for it.

If you are in a special population, dont leave it until public health calls with an appointment. If youre vaccine-hesitant, talk to your doctor. Ask questions. Express your concerns, Ray said

Understanding is knowledge and knowledge is power.

Wellington-Dufferin-Guelph Public Health also has vaccine information on its website.

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Experts speak the plain truth about COVID-19 vaccine - Wellington Advertiser

President Arif Alvi calls for promotion of book reading culture to suppress biases – The Nation

ISLAMABAD-President Dr Arif Alvi on Sunday called for promotion of book reading culture to enhance knowledge and suppress biases.

The president, in a video message, advised the people particularly the youth to develop the habit of book reading to enhance their exposure and help suppress the biases.

He said he studied books on current affairs and computer sciences and tried to disseminate his knowledge to the masses through his speeches.

The president shared a list of 10 of the books he read last year encompassing the subjects including Islamic history, capitalism, history of subcontinent, upheaval and exploitation in nations, human psychology, riots in India, metric society, physics and artificial intelligence. He said besides the books recommended by him, the people should also read the useful material of their choice.

The president said when it comes to obtaining huge knowledge published in the form of books, he considered his life too short to comprehend it all. He also showed the notes of various books he took during the reading which he hoped to compile at a later stage.

I do nothing else but read books during travel, be it by car or air. I study book as I go home.

Though I get a little chance to read books in office, I do it when there is some gap, he remarked.

The president, who had also shared his best reads, put at top a book Revelations by Meraj Mohiuddin presenting a wide variety of scholarly viewpoints on the story of Holy Prophet Muhammad (Peace be Upon Him) and Quranic revelation.

He also strongly recommended Art of Thinking Clearly by Rolf Dobelli on human psychology and reasoning. The book points out around 100 biases found in humans, meant for self-examination and methods to avoid them.

Other books recommended by the president included Capital and Ideology by Thomas Piketty (on economic inequalities and suggesting outlines for fairer economic system), Anarchy by William Dalrymple (on rise of East India Company and economic prosperity in subcontinent), Upheaval: Turning Points for Nations in Crisis by Jared Diamond (history of different nations like Japan, Soviet Union and their efforts to overcome crises), Why Nations Fail: The Origins of Power, Prosperity, and Poverty by Daron Acemoglu and James Robinson (exploitative society which begets change and leads to revolution).

He said currently, the same battle is going on in Pakistan against the corrupt rulers and system.

President Alvi also recommended The Metric Society: On the Quantification of the Social by Steffen Mau (measurement and evaluation in the society), and The Big Picture by Sean M. Carroll, Sean B. Carroll (scientific worldview and exploration of God).

The tech-savvy president suggested the people to study Life 3.0: Being Human in the Age of Artificial Intelligence by Deckle Edge (how science is advancing and becoming a challenge for humanity) and Superintelligence by Nick Bostrom (growing influence of machines and possible replacement of humans by super intelligence).

Other than his 10 best reads, the president also suggested The End of India by Khushwant Singh (communal violence in Gujarat in 2002 and rise of religious fundamentalism in India), Gujarat Files by Rana Ayub, Allama Iqbals The Reconstruction of Religious Thought in Islam and MJ Akbars Riot After Riot: Reports on Caste and Communal Violence in India.

Other books recommended by the president included Protocol by Capricia Penavic Marshall, Makers of Modern Sindh by Dr Muhammad Ali Shaikh (on life of Sindhs prominent figures), A Promised Land by Barack Obama and Jinnah and Tilak: Comrades in the Freedom Struggle by AG Noorani and Tuba by Shah Baligh-ud-Din, The Last Mughal by William Dalrymple and World Enough and Time by Sultan Muhammad Shah Aga Khan.

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President Arif Alvi calls for promotion of book reading culture to suppress biases - The Nation

Marine Toilets Market 2021: Qualitative and Quantitative research | Jabsco, Raritan Engineering, Reliance Products, Sealand (Dometic), Thetford …

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North America(the United States, Canada, and Mexico)Europe(Germany, France, UK, Russia, and Italy)Asia-Pacific(China, Japan, Korea, India, and Southeast Asia)South America(Brazil, Argentina, Colombia, etc.)The Middle East and Africa(Saudi Arabia, UAE, Egypt, Nigeria, and South Africa)

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Marine Toilets Market 2021: Qualitative and Quantitative research | Jabsco, Raritan Engineering, Reliance Products, Sealand (Dometic), Thetford ...

ReCAAP ISC issues incident alert on incidents against ships in the eastbound lane of Singapore Strait – American Journal of Transportation

ReCAAP ISC today issued an Incident Alert (01/2021) on incidents against ships in the eastbound lane of Singapore Strait:

The incidents of armed robbery against ships continued to occur to ships while underway in the Singapore Strait

During 25 29 Jan 2021, three incidents were reported on board ships while underway in the eastbound lane of the Traffic Separation Scheme (TSS) in the Singapore Strait

The three incidents occurred in close proximity to each other and in particular, two incidents occurred within an interval of four hours

In all three incidents, the perpetrators were sighted in the engine room

However, nothing was reported stolen and the crew was safe with no confrontation with the perpetrators

ReCAAP ISC is concerned with the continued occurrence of incidents in the Singapore Strait

In 2020, a total of 34 incidents were reported in the Singapore Strait; of which 30 incidents occurred in the eastbound lane, two in the precautionary area, one in the westbound lane and one just outside (south) of the TSS

The ReCAAP ISC had issued five Incident Alerts on the incidents occurred in the eastbound lane of the TSS in the Singapore Strait and one Special Report on incidents against ships in the Singapore Strait in 2020

All ships are advised to exercise enhanced vigilance, adopt extra precautionary measures and report all incidents immediately to the nearest coastal State

Ship master and crew are advised to keep abreast of the latest situation (at https://www.recaap.org/) and tune-in to advisories and navigational broadcasts announced by the littoral States

The ReCAAP ISC urges the littoral States to increase patrols and enforcement in their respective waters, strengthen coordination among them and promote information sharing on the latest situation, and the criminal groups involved in order to make arrests of the perpetrators

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ReCAAP ISC issues incident alert on incidents against ships in the eastbound lane of Singapore Strait - American Journal of Transportation

I woke up at 4:30 a.m. for a week like a Navy SEAL and it made me more productive – Yahoo News

Following is a transcript of the video.

Emma Fierberg: I wanted to test out for myself how waking up at 4:30 affected my productivity. I woke up at 4:30 a.m. for one week, like a Navy SEAL. I've read a lot about how Navy SEALs like Jocko Willink wake up at 4:30 in the morning. Jocko famously says that discipline equals freedom.

It is Friday, two days before I start this experiment. Normally my alarm goes off five minutes before 8:00 a.m. Setting my alarm a full three and a half hours earlier is gonna be really scary. Will I survive?

The Plan

So, we're gonna try to wake up at 4:30, do some sort of exercise, some sort of activity like a puzzle, or nails, or do some cooking maybe, make some breakfast, get dressed, and I'm gonna try to get to work by 7:00, and then I will try to be in bed by 8:00 p.m.

Challenges

I know I'm gonna break this bed by 8:00 p.m. rule, because I already have plans next week that start at 7:30. The gym in my building doesn't open until 6:00, so I'm gonna try and kill an hour and a half outdoors. I don't drink coffee, so this is probably gonna be pretty hard for me. The bag cam, what are the eye bags looking like? Pre-4:30 a.m. eyes.

It is Sunday night, it is 9:42 p.m. I am going to attempt to go to sleep. That's just not enough hours.

Monday

Never have I ever cooked at 5:20 in the morning. Here we are, 7:30 a.m. I have made my lunch for the entire week, minus Friday, I have straightened my hair, and that is it. Let's see who's here. Oh, surprise! Nobody. I was a little loopy, I was a little giddy, and then around lunchtime, I got a little hangry and I ate my lunch that I made this morning, and that got my energy back up a little bit, and then, like, 1:15, 2:00, I was just.

Story continues

Jacqui Frank: What are you doing tonight after getting up at 4:30?

Fierberg: We're going to the movies! I don't even know what to say. I'm so tired. I was pretty productive. I did finish a video. I can see already why this is a good idea for certain people. I don't know if that certain people is this people. If I had to rate my energy level from zero to 10, I would say I'm about a four and a half.

Tuesday

It's Tuesday! So, today I woke up at 4:30 and I went for a run. I hate this so much. Not a runner. Ooh, I see a rat. Oh, a duck! Look at all the wildlife! I ran for about six minutes. High five. That's what I thought. And just like that, folks, I'm a human being before 7:00 a.m. I would never describe a run as peaceful before today, but it was. The lighting was lovely. I think exercising in the morning helped me stay a little more chipper. I felt more confident today. I would say, on a scale from zero to 10, I feel about a seven. Oh, oh, and the bag cam. How are the bags doing today? My grandma calls them suitcases.

WednesdayI turned off the alarm, and then I sat in bed on my phone for about a half an hour. And then, at 5:00, I was like, alright girl, it's time, you're gonna do a thing. And guess what I did? I painted my nails! I also painted my toenails. I did a really bad job. And then I had my phone call with my friend Dana, who lives in Israel, who's seven hours ahead of me. So that was a plus. I had an interview today with someone I've been trying to get in contact with for a while, and it went really well, so I was really hype for, like, 45 minutes, and then just crashed. I had such a hard time this morning. I got into work and I couldn't function. I'm gonna play my kickball game, and I'm gonna try to go to bed by 8:00. I know that's not gonna happen, but I need to actually try. The bedtime is what's messing me up. Just got back from kickball. It's 9:12, I'm going to bed, bye!

ThursdayHi, it's Thursday, and I am much more alert! I had all this footage from a trip that I went on with my family in November, and I had never pieced it together into any sort of cohesive thing, so that's what I did this morning. I finished it, finally. And then I changed and went to the gym, then I showered and I came to work. As you can see, my energy levels are pretty high today. I cracked the formula. If you go to bed at a reasonable hour, and then you do exercise when you wake up, bag cam, bag cam. I'm looking okay today, I think.

Friday

It's Friday. Made it. I did wake up and I went for a walk at the Brooklyn Bridge, which was lovely. The weather was a perfect 72 degrees, the light was beautiful, there weren't too many clouds. Oh, it was a dream. Everyone should wake up and see the sunrise at the Brooklyn Bridge once in their life, just once. I got to call my British mom today, because they're five hours ahead, so I called her at about 5:30 this morning, and that was really nice to catch up with her. I was actually incredibly productive today for two reasons. One, I figured out the sleep schedule. Two, it's the end of Q2 and everyone was hustling. I feel okay. How do my eyes look? Check out the bag cam.

Conclusions

I have major respect for Navy SEALs who wake up at 4:30 in the morning, anyone who works night shifts, has wild hours, kudos, I get it now maybe a little bit, maybe not to the fullest extent, but, like, wow. All in all, at the end of this experiment, I understand now why people wake up at 4:30. You feel really good about yourself when you're productive before everyone else you know has even risen from the pillow. I don't know if this 4:30 time is gonna stick. I did like being awake at sunrise, but sunrise is like 5:30, so maybe I'll push to a 6:00 a.m., 6:30 wake up. Having a regimented wake up time was really useful for me. I could feel a little more rested, but other than that, I've achieved a lot of things I've needed to do for a long time this week. I think waking up at 4:30 really opened my eyes. Now that this week is over, I'm gonna go take a nap. I'll see you guys later.

EDITOR'S NOTE: This video was originally published July 26, 2018.

Read the original article on Business Insider

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I woke up at 4:30 a.m. for a week like a Navy SEAL and it made me more productive - Yahoo News

NASA Mars Perseverance rover: What to expect on landing day – CNET

NASA will use a "sky crane" to gently lower Perseverance to the surface of Mars.

When it comes to spacehappenings, few things are as thrilling as landing a vehicle on another planet. It's tense. It's exciting. It's high stakes. On Feb. 18, NASA's Perseverance rover will aim to stick the landing on Mars, kicking off a new era in red planet exploration.

While NASA has a lot of experience with delivering machines to Mars (here's looking at you, Curiosity and InSight), that doesn't make it any easier this time. "Landing on Mars is hard," NASA said. "Only about 40% of the missions ever sent to Mars by any space agency - have been successful."

It's going to be a wild ride. Here's what to expect on Perseverance's landing day.

From the lab to your inbox. Get the latest science stories from CNET every week.

NASA will provide live coverage of the landing. The NASA TV broadcast from mission control kicks off on Thursday, Feb. 18 at 11:15 a.m. PT. Touch down in the Jezero Crater on Mars is scheduled for around 12:30 p.m. PT.

This won't be like a rocket launch where we get to see every detail as it's happening. We will get NASA commentary and updates, views from mission control, and hopefully some images not too long after landing. It will be a must-watch event for space fans.

We've been to Mars before. So why all the hype? The red planet is our solar system neighbor. It's rocky like Earth. It has a long history of water. We can imagine ourselves perhaps living there some day.

"The level of interest that people have in this planet is just extraordinary," Alice Gorman-- space archaeologist and associate professor at Flinders University in Australia -- told CNET. Gorman highlighted humanity's search for life beyond Earth and how Mars is a candidate for having hosting microbial life in its ancient past.

There's also something special about a rover, a wheeled mechanical creature with a "head" and "eyes." "People feel towards the rovers because they're active and they move," said Gorman, likening it an almost parental sense of attachment. The outpouring of emotion over the demise of NASA's Opportunity rover proves how connected humans can get to a Mars explorer. Perseverance is set to become our new Martian sweetheart.

Mars arrivals are always harrowing. NASA calls the process EDL for "entry, descent and landing."

"During landing, the rover plunges through the thin Martian atmosphere, with the heat shield first, at a speed of over 12,000 mph (about 20,000 kph)," said NASA in a landing explainer. There's a reason NASA describes the landing process as "seven minutes of terror."

This NASA graphic shows the entire entry, descent and landing (EDL) sequence.

Small thrusters will fire to keep the rover on track on the potentially bumpy ride through the atmosphere. The rover's protective heat shield helps to slow it down. At an altitude of around 7 miles (11 kilometers), asupersonic parachute will deploy and Perseverance will soon separate from its heat shield.

NASA gave a briefing on Jan. 27 with a detailed rundown on the entire EDL sequence, including the "sky crane" maneuver, which lowers the rover the final distance to the surface using a set of cables.

If all goes well, Perseverance will end up standing on the surface of Mars. "The really hard part is to soft land and not crash land, and then to deploy the moving parts," said Gorman. Perseverance is not alone on the trip. It also carries a helicopter named Ingenuity in its belly. Ingenuity will be unleashed later in the mission.

Now playing: Watch this: How NASA's Mars helicopter could change the future of...

5:20

The mission is equipped with cameras and microphones designed to capture the EDL process, so we can expect to both see and hear the excitement of the landing at some point. "It will be the raw sounds of the descent and coming onto the surface," said Gorman. "So that's a whole other level of sensory engagement."

It takes time to send data between Mars and Earth. For us back home, we can expect a first photo not too long after landing, but the full visual and audio experience may take a few days for NASA to share with the world.

The agency released an arrival trailer in December that shows an animated, sped-up version of the process. You'll get the idea of just how wild it is to land a rover on another planet.

Gorman is excited about getting visuals of the rover's landing spot in Jezero Crater. It will be our first close-up look at the landscape in an area that had a history of water. Perseverance hopes to explore that history and look for evidence of life.

While the photos, sounds, helicopter and all-around science will be reasons to celebrate, there's the big lingering question the mission might answer: Was Mars home to microbial life? Said Gorman, "It would just be really great if we've got a bit of a closer handle on whether anything once lived on Mars."

Perseverance is our next great hope in the search for signs of life beyond Earth. It all starts with sticking the landing.

FollowCNET's 2021 Space Calendarto stay up to date with all the latest space news this year. You can even add it to your ownGoogle Calendar.

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NASA Mars Perseverance rover: What to expect on landing day - CNET