Sheriff declares he will not enforce laws that infringe on Second Amendment – Daily Journal

The county commissioners and Sheriff Duane Burgess stopped short of declaring Johnson County a Second Amendment sanctuary, but declared that county resources would not be used to enforce laws that infringe on gun rights.

Burgess was asked by residents to clarify his stance on the issue, so he put his thoughts to paper in a legal document as a promise to county residents, he said.

The people have rights and must be protected, and people must know where their elected sheriff and officials stand," Burgess said. "People have the right to protect themselves and their property. They have the right to keep and bear arms.

Locally, the ordinance declares, Johnson County shall be a county in which the Constitutional right to keep and bear arms is deeply honored and protected against unlawful infringement; and that the Johnson County Commissioners and Johnson County Sheriff hereby declare their opposition to any law or regulation that unlawfully infringes upon the right to keep and bear arms, and it shall, therefore, be the policy of the Johnson County commissioners and the Johnson County sheriff not to utilize county resources in a manner that unlawfully infringes upon the right to keep and bear arms.

The 2013 ordinance did not include a pledge from the sheriff to not enforce laws that infringe on gun rights such as a mass gun seizure, instead saying the commissioners would oppose rights infringements they believe are contrary to the constitution. The new resolution cements the countys commitment further, with Burgesss declaration that any such laws would not be enforced.

Burgess and Johnson County commissioner Brian Baird said county officials are of the opinion that additional gun rights should not be taken away, but existing gun laws will continue to be enforced. For example, Baird said the sheriffs office would respond to and take action against individuals who possess illegal guns such as automatic weapons or those who carry a gun in public without a license.

The most likely way this resolution could be put into action is some type of mass guns seizure, Burgess said. He and Baird said the county feels strongly that any weapon seizure should not be undertaken without modifying the constitution.

As sheriff, Burgess knows that many gun laws are necessary, for example, the Jake Laird Law, also known as the Red Flag Law, which allows law enforcement to take guns from someone who is mentally unstable or poses a potential threat to society. For him, the distinction between laws such as this and a mass seizure is that the latter would impact law-abiding citizens. Rather than any specific potential legislation, the resolution is meant to protect law-abiding citizens from having guns taken from them unconstitutionally, Burgess said.

Legal experts doubt the validity of local resolutions promising to not enforce gun laws, given that municipalities are superseded by state and federal laws. Under the state constitution, counties operate exclusively on the powers that are endowed to the units of government by the General Assembly, according to a guide on county government from the Indiana Association of Counties. Experts say, because laws would either come via the executive or legislative branch, county government would be beholden to uphold the law.

However, is not clear what consequences there would be if a state or federal law passed and Burgess refused to enforce it, Baird said.

Until something would come up, you dont know what is going to happen; everybody knows that. I hope this is never tested, Baird said. I swore an oath to protect the constitution and I will do that until my last breath.

In 2013, Johnson County became one of the first in the state to pass a Second Amendment protection ordinance. Since the first of this year, Burgess, Baird and Greg Ileko, a Bargersville man involved with the countys Second Amendment protection group, have been working with legal counsel to update the ordinance and clarify the countys stance.

Baird and Burgess have been discussing this new resolution, which the Johnson County Board of Commissioners passed unanimously, since Burgess took office last year, Baird said.

Passing the resolution moved up the priority list when the Second Amendment sanctuary movement ignited across the country after controversial gun laws were passed in Virginia, said Ilko.

Indianas Second Amendment sanctuary movement is led by a group called Indiana 2a United. The groups members have convinced 25 counties to pass some type of 2a protection measure, according to pro-2a sanctuary website, sanctuarycounties.com. As many as 959 counties across the country have passed similar measures with encouragement from local gun rights activists, the website says.

Not all counties that have had Second Amendment protection measures proposed have passed legislation. For example, Bartholomew County commissioners and the Columbus mayor declined to pass proposed sanctuary legislation in January.

Bartholomew County officials saw sanctuary legislation as an attempt to bypass the court system, according to a statement they provided to the Columbus Republic.

The question of whether the Constitution has been followed is within the sole province of the Courts to determine. It appears that the intent and purpose of this proposed Ordinance is to attempt to usurp or supersede the authority of the Courts, the statement read.

For activists like Ilko, a commitment from the county government to protect gun rights means a lot at a time when many fear further infringement, he said. Though a resolution has a less powerful statement than an ordinance, Ilko said the gesture is important to local gun owners. An ordinance is a piece of legislation that carries more weight, whereas a resolution is a formally expressed opinion that is agreed upon with a vote.

It is the opportunity for the silent majority to not be silent anymore. There is a big push and an anti-2a facet out there, Ilko said. Having our sheriff and public officials stand up takes some moxy and I appreciate it.

On gun rights or any issue, Burgess said his door is always open when residents have concerns about law enforcement issues.

As the sheriff of Johnson County, I feel that it is important to be proactive and look at all sides when making a decision, Burgess said. We all may not agree on certain things or issues, but at the end of the day, you have to be willing to accept that persons view and continue to work toward a solution.

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Sheriff declares he will not enforce laws that infringe on Second Amendment - Daily Journal

A Family Cries Justice for Hannah. Will Its Rural Town Listen? – The New York Times

SEDALIA, Mo. Seven weeks had passed, and still there were no answers. So once again, a small cluster of friends and family gathered in the leafy courthouse square and marched for Hannah Fizer, an unarmed woman shot and killed by a rural Missouri sheriffs deputy during a traffic stop.

Say her name! Hannah!

Prosecute the police!

Their chants echoed protests over police killings in Minneapolis, Louisville, Atlanta and beyond. But this was no George Floyd moment for rural America.

Though people in rural areas are killed in police shootings at about the same rate as in cities, victims families and activists say they have struggled to get justice or even make themselves heard. They say extracting changes can be especially tough in small, conservative towns where residents and officials have abiding support for law enforcement and are leery of new calls to defund the police.

Its like pulling teeth, Ms. Fizers mother, Amy, said.

The deputy who shot Ms. Fizer has not been charged or disciplined, and Ms. Fizers parents say they have not received any updates about the investigation into her June 13 death. They said that investigators never interviewed them, and that the sheriff declined to tell them the name of the deputy who shot her.

Over the weeks, the rallies for Ms. Fizer tapered from a hundred protesters to a couple dozen. Every Saturday morning, they wave signs and ask passing cars to honk in support of the 25-year-old woman with a big grin and flower tattoo, who loved swimming and Chinese takeout and dreamed of having children, and of a larger life beyond her night-shift job at a gas station. Her family and friends have become her movement.

Were just doing it all on our own, Amy Fizer said.

There are hundreds of stories of law enforcement killings in small towns and rural areas, but scant research into how and why they happen. One analysis by FiveThirtyEight found that between 2013 and 2019 there was a slight rise in shootings by officers in rural and suburban areas and a decline in big cities. Experts say rural shootings may be tied to higher rates of gun ownership, a lack of mental health services, or insufficient training for officers responding to people in crisis.

Ms. Fizers parents said they know only the barest facts about what happened the night she died.

She spent the last day of her life splashing around in a kiddie pool with her best friend, Taylor Browder, and Ms. Browders young children, talking about life and her future in Sedalia, an old railroad town of 21,000 people that is home to the Missouri State Fair. Ms. Fizer had attended the Sedalia Police Departments citizens academy in 2016 but quickly decided she did not want to become a cop. She sometimes talked about working as a parole officer.

Ms. Browder said that Ms. Fizer headed home to the apartment she shared with her boyfriend to take a nap and shower before her overnight shift at the Eagle Stop gas station on the western edge of town.

At about 10 that night, a Pettis County sheriffs deputy pulled her over for speeding. In an interview, Sheriff Kevin Bond said that the deputy met with verbal resistance when he walked up to Ms. Fizers car and that he told investigators she claimed she had a gun and threatened to kill him.

Ms. Fizers friends and family have a hard time believing that. Ms. Fizers boyfriend owned a gun, they said, but in a conservative county where the Second Amendment is sacrosanct, Ms. Fizer did not like guns or carry one.

Investigators later found five shell casings by the drivers side door of her Hyundai, but no gun in her car.

David Hemenway, director of the Harvard Injury Control Research Center, said the prevalence of guns may explain why cities and rural areas have nearly equal rates of law enforcement killings even though murders and violent crime rates tend to be higher in cities.

More than half of the people fatally shot by rural officers were reported to have a gun, according to a seven-year tally by Mapping Police Violence. Ms. Fizer was among the roughly 10 percent who were unarmed.

Ms. Fizer and the deputy who shot her were both white, a common dynamic in shootings that occur in overwhelmingly white, rural parts of the country. Black and Hispanic people are killed at higher rates than white people in rural areas, but the demographics of rural America mean that about 60 to 70 percent of people killed by law enforcement there are white, according to an analysis by Harvard researchers.

Unlike in other cases that have galvanized efforts to change policing, there is no body camera footage of the shooting. The sheriffs office stopped using body cameras after software problems and a crash on the hard drive that recorded the data. Fixing it was just cost prohibitive for a rural sheriffs office where money is tight and starting pay for deputies is $26,000, Sheriff Bond said.

Sheriff Bond said there had been no prior use-of-force complaints against the deputy who shot Ms. Fizer. The deputy, who has not been named, was put on paid leave, and the sheriff said he immediately called in the Missouri State Highway Patrol to handle the scene and investigate the shooting.

The Highway Patrol finished its investigation last week and handed over a report to the Pettis County prosecuting attorney, who had a special prosecutor appointed. Ms. Fizers family said they have not been told about the results of the report, and have been following developments through the news.

If this wouldve happened in the city, something would have been done by now, said Haley Richardson, a friend who said Ms. Fizer was kindhearted and stood up for vulnerable people. Were going to stay out here. We just want answers.

Ms. Fizers relatives said that a divide in money and class between them and authorities in Pettis County had made them feel like second-rung citizens. Ms. Fizer was not rich, and members of her family had been in and out of prison and struggled with drug addictions.

If youre on the outer fringes of society youd know, Amy Fizer said. They pull you over. They do what they want, when they want.

Some of Ms. Fizers friends and relatives said they had already been outraged by Mr. Floyds killing in Minneapolis police custody, which happened about three weeks before Ms. Fizer was shot. They joined Black Lives Matter rallies as the movement spread throughout small towns across America.

But they also emphasized that they did not want to abolish the police. They supported law enforcement. Just not this deputy, or this sheriff. The aftermath of the shooting led to calls for Sheriff Bond to resign and prompted a police sergeant in suburban Kansas City to challenge the sheriff in Novembers election.

You have law enforcement running around without any body cameras, dash cameras, the minimal equipment, said the challenger, Brad Anders, who lives in Sedalia. The investigation, whatever it may reveal, is never going to be enough. There are questions that will never be answered.

The anger over Ms. Fizers death exploded on local Facebook groups. Sheriff Bond said people had threatened to publish his home address and harassed and threatened a deputy and his family, and he warned that instigators were using Ms. Fizers death to sow social chaos.

When a statue of a World War I doughboy infantryman honoring veterans was vandalized in July in the town square an incident unrelated to the protests for Ms. Fizer his officers opened an investigation and arrested an 18-year-old on vandalism charges.

Do you want this to continue and cause irrevocable harm to our community? the sheriff wrote. Are you willing to allow Pettis County to become the test project for some social justice experiment for rural America?

Ms. Fizers father, John, had complicated feelings about the upwelling of nationwide anger at the police. He was angry. He wanted justice for his daughter. But he counted himself as a conservative Republican and worried that the protests in Sedalia could be co-opted by left-wing outsiders a pervasive, but largely unfounded fear in small towns after Mr. Floyds killing.

In a Facebook post, Mr. Fizer wrote that he did not want Antifa-type outrage here in our quiet hometown.

I love my law enforcement, he said. Id hate to think where wed be without them.

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A Family Cries Justice for Hannah. Will Its Rural Town Listen? - The New York Times

Nintendo profit jumps more than 400% thanks to the Switch and ‘Animal Crossing’ – KTVZ

Nintendo sales are still soaring.

The Japanese company posted another round of blockbuster earnings Thursday, proving that its hot streak from the pandemic is far from over.

The company said it made 145 billion yen ($1.37 billion) in operating profit for the quarter ended June, marking a 428% surge compared to the same time a year ago. That blew away expectations from analysts, who had estimated about 62 billion yen of profit, according to data provided by Refinitiv.

Nintendo also doubled sales from a year ago, taking in about 358 billion yen ($3.4 billion).

The results show that months into the pandemic, people are still turning to the Nintendo Switch game console in droves. Nintendo sold about 5.7 million of the devices from April through June, marking a 167% increase year-over-year.

The runaway success of Animal Crossing: New Horizons continued to be a boon for the company. The game, which is set on a relaxing virtual island utopia and allows users to fish, catch bugs and play with friends on the beach, runs on the Switch and has been in high demand since people worldwide started staying home because of the coronavirus pandemic.

Nintendo sold 10.6 million copies of the game in the most recent quarter.

Sales of this title continue to be strong, with no loss of momentum, the company said in a statement. It added that the game was its bestseller this quarter, contributing greatly to the overall growth in software sales.

Nintendo has sold 22.4 million copies of Animal Crossing overall, putting it just under Nintendos best-selling game of all time, Mario Kart 8 Deluxe. That title has racked up 26.7 million sales.

The Switch, which was first released in 2017, sold out on various websites earlier this year as customers scrambled to find new forms of home entertainment.

This spring, the Kyoto-based company ran into supply issues with the Switch as factories were shut down in China. Those closures triggered some component shortages and slowed output at factories in Vietnam.

Now, the overall production situation has almost recovered, the company said.

Nintendo also took the opportunity to tease its pipeline of games. This fall, it plans to release a new title, Pikmin 3 Deluxe, as well as offer some new content for Pokmon players. The company released another new Switch game, Paper Mario: The Origami King, last month.

We will work to keep the platform active with new titles and by reinforcing sales of popular titles that have already been released, the company said.

Kaori Enjoji contributed to this report.

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Nintendo profit jumps more than 400% thanks to the Switch and 'Animal Crossing' - KTVZ

Terminal Nation discuss every track on their killer new album (which is streaming) – Brooklyn Vegan

intro by Andrew Sacher and Erin Christie

With protests against racism, police brutality and other injustices happening all across the country this year, protest music has been hitting even harder than usual, and Little Rock, Arkansas band Terminal Nation's new album Holocene Extinction is 35 minutes of in-your-face, abrasive, cathartic, really fucking good protest music. They pull from early death and black metal as much as they pull from hardcore punk, and their songs exist within a thrilling middle ground that never fits neatly into any of those genres.

Lyrically, the album takes on the failings of the prison industrial complex, the pharmaceutical industry, and the war machine. It turns the mirror back around on those in power, and those who claim "patriotism." It's a record that asks not for reform, but an entire dismantling of the system. It resonates especially strongly right now, and it will continue to until there's some real change.

Holocene Extinction officially comes out Friday (8/7) via 20 Buck Spin (pre-order), but you can stream the whole thing right now. Vocalist Stan Liszewski also gave us a breakdown of each song on the album, so click play right here and then scroll down to see what Stan had to say...

1. "Cognitive Dissonance"Admitting you are wrong is an incredibly difficult thing to do. It's a humbling experience, to say that you once had an awful mindset, but you've changed and now think differently. That shows growth. There are some hard-headed, obtuse types who use all sorts of mental gymnastics to justify their wrong and antiquated views, rather than just take their L and move on. I think, deep down, they know that they're wrong, but they're stuck on a sinking ship and committing to their bit until the end."The line in the sand's been drawn. Which side will you be on?"

2. "Arsenic Earth"The planet is dying. This track is a frustrated and rage-filled perspective from the sidelines while we watch our home being destroyed. This is me screaming into the void, "How did we let this happen?," and because we let this happen, maybe we deserve what's coming."After 200 years humanity has stolen two million years off of the life of the Earth. Mother nature, I beg that you show us no mercy, just as we have to you."3. "Holocene Extinction"If "Arsenic Earth" is me being frustrated with humanity, "Holocene Extinction" is the rebuttal to that, and my frustrated self-reflection at that mindset. It's not humanity as a whole that's at fault for this current climate crisis, but rather, capitalism. Those in power have too much money at stake for things to ever be allowed to change. The almighty dollar is at the bottom of this all and, as it stands now, we have crossed the point of no return."You cannot save a world that refuses to be saved. Holocene Extinction."

4. "Master Plan"This track is about various American institutions like the prison industrial complex, the police, the use of immigration camps, etc., and how people often refer to them as 'broken systems.' Many think that these programs have potential to be reformed. I'd disagree with that; to advocate for reform of these institutions implies that they have failed, but they have not failed. These are not 'broken systems;' they are functioning exactly how they were intended to. They were made to inflict harm, gain control over, and profit off society's most vulnerable and marginalized people. This was always their Master Plan."To advocate for reform of these violent institutions implies that they have failed, but they have not failed. This is exactly what they were always meant to be. The system is not broken, this is their master plan."

5. "Revenge"This is a fun throwback. The frame of this track was used in our first EP, Waste. It was the heaviest track on that record and it was deserving of a redo. We beefed it up production-wise and added a few new interesting parts. Simply put, this track is about the desire to exact revenge on those that have harmed you and harmed those that you love."Fuck around and find out."

6. "Thirst To Burn"To piggyback on "Revenge," sometimes taking the high road means whoopin' some ass. Sometimes people absolutely need to be taken down by force. There is often privilege in saying 'violence isn't the answer.' Those saying that 'violence doesn't solve anything' usually don't have to live in fear of being on the receiving end of violence. There can be a great deal of risk involved in standing your ground, but sometimes, there is no other option."I would risk it all, just to see them fall."

7. "Orange Bottle Prison"The pharmaceutical industry in the United States is a scam. I think we all know someone, or perhaps at one time or another, have personally avoided taking a particular drug that was deemed necessary by a physician because we couldn't afford it. I know I have. It's unfortunate, but making life-saving medicine affordable isn't something that fits within the scope of their current business model."If the drugs don't kill me then the price of them will, price-gouging the sick, pay or be fucking killed."8. "Leather Envy" Some people love the taste of that leather boot a little too much. Death to all bootlicking."Those who bow to their own oppressor are the weakest link in the chain of being."

9. "Expired Utopia"This is the first time Terminal Nation has experimented with an instrumental track. It starts off with one riff, and if you listen closely, every 2 measures or so, you'll hear another riff layered on top of the previous one and it stacks up well. Even without lyrics, this song tells a story. Similar to "Holocene Extinction," this is a somber melody about the helpless feeling of knowing things are probably too far gone to be fixed. You often hear that once things get better, future generations will look back on this time and view it as a dark period, but what if there are no future generations? What if things won't get better? What if they only get worse? Any redeeming possibility for a peaceful utopian future has all but expired.

10. "Death For Profit"War is extremely profitable and no one partakes in the business of war quite like the United States of America. American imperialism has run amuck for generations now, and the indoctrination of blind patriotism is what fuels that imperialism."The smell of money is used to hide the stench of death. Death toll rising or strategic ratings boost? Blinded by the concept of patriotism this is the empowerment of imperialism. Death for profit to the highest bidder, when will we ever learn?"11. "Caskets of the Poor"Military recruiters view poor, marginalized, and underprivileged youth as fodder. They prey on young, poor folks with pipedreams of a better life and send them to die to benefit the old, powerful, and rich. It's a tale as old as time."I pledge allegiance to perpetual war and the flag that blankets the caskets of the poor."

12. "Disciple of Deceit""Disciple of Deceit" is about these right-wing politicians and political types who use their cherry-picked version of Christianity as a means to infringe upon the existence of others. They'll go after things like marriage equality, other religious beliefs, trans rights, abortion rights, and more, taking stabs at some of the most vulnerable and marginalized groups in the US, yet, upon meeting any resistance to their regressive way of thinking, they develop a persecution complex and act as if they are the ones that are the oppressed."You wouldn't know oppression if it nailed you to the fucking cross."

13. "Age of Turmoil" The closing track on the LP is a culmination of all of the topics that are previously touched on, but from a perspective that's a bit more hopeful. Who knows exactly what the future holds for us, but in the interim, we've got to look out for one another and weather through this age of turmoil."No pasarn!"

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Terminal Nation discuss every track on their killer new album (which is streaming) - Brooklyn Vegan

These are the latest Apple Arcade games for iPhone, iPad, iPod touch, Mac, and Apple TV – 9to5Mac

Apple Arcadelaunched with close to 100 titles and the service is seeing new games added regularly. Follow along with our guide on the latest from Apples gaming service.

You can learn more about and downloadall the new games by heading to the Arcade tab in the App Store, then swipe down to the very bottom and tap See All Games. The newest games are listed at the top.

If you havent signed up yet, Apple Arcade is available free for the first month, then $5/month for iPhone, iPad, iPod touch, Mac, and Apple TV. PS4 and Xbox wireless controllers are also now compatible with Apple devices and select titles.

8/7: Apple Arcade gainsGame of Thrones: Tale of Crowsas the newest title taking players back 8,000 before Jon Snow.

In the shadow of the Wall, your watch begins. Eight thousand years before Jon Snow took the Black, the Nights Watch was formed to secure the Wall and defend the border of Westeros against the perils of the North, and all that lies beyond. Into these untamed wilds, sworn brothers and their allies set out on rangings to face the dangers that would threaten the realm. But the Wall is a blade that cuts both ways.

Guide the decisions of Lord Commanders through the seasons and mount expeditions beyond the Wall. As ravens travel to and from your expeditions in real time, their messages are delivered to you throughout your day. Respond with your command right away, or whenever you see fit.

Long is the history of the Nights Watch, and many are its stories forgotten. Its time the realm remembers them.

7/24:Landing on Apple Arcade today isThe Lullaby of Life, an adventure game with a focus on music, relaxation, and agility.

In The Lullaby of Life you are the catalyst for change in a universe currently inert but filled with potential.

Explore this amazing world that combines relaxation, dexterity and agility, and help it reach its maximum splendor using the power of music to make life bloom.

This adventure has no textual elements, and wearing headphones is highly recommended. Lets write together a new story about the origin of life!

7/17:Necrobaristais the newest addition to Apple Arcade. Heres the description of the new dark adventure title:

In a back-alley Melbourne cafe, the dead are granted one last night to mingle with the living.For Maddy Xiaobarista, amateur necromancer, and new owner of the Terminalthings couldnt be better, as long as youre not reminding her of the fact that shes got an enforcer from the notoriously uncompromising Council of Death breathing down her neck.

7/10:New to Apple Arcade today is a dark and eerie adventure puzzler called Creaks.

The ground starts shaking, light bulbs are breaking and something rather unusual is happening right behind the walls of your very room. Equipped with nothing but wit and courage, you slowly descend into a world inhabited by avian folk and seemingly deadly furniture monsters.

From the creators of indie classics Machinarium and Samorost comes Creaks, a new puzzle adventure game that delights the senses with its hand-painted visuals, precise animation, eerie sounds, and an eclectic original score from Hidden Orchestra. Proceed at your own pace at figuring out the solutions to dozens of carefully designed puzzles, explore the mansion for hidden paintings, and uncover the great secret.

6/25: A big release today on Apple Arcade is the futuristic adventure thriller and sequel to the popularBeneath a Steel Sky,Beyond a Steel Sky.

From Charles Cecil, creator of the Broken Sword series, with art direction by Dave Gibbons, legendary comic book artist behind Watchmen, comes Beyond a Steel Sky, the long awaited sequel to the cult classic Beneath a Steel Sky.

You are Robert Foster. A child has been abducted in a brutal attack. You have vowed to bring him home. But the trail has led you from your community of desert wasteland dwellers, to Union City, one of the last remaining mega-cities in a world ravaged by shattering wars, and political meltdown.

Fortified and impenetrable, it is a utopia in which people live happily under the surveillance and control of a benign AI. But all is far from what it seems

Beyond a Steel Sky is a dramatic, humorous, cyberpunk thriller in which engaging puzzles drive a fast-paced narrative set in a dynamic gameworld that responds to and is subverted by the players actions.

An adventure set within a dynamic world, populated by willful characters driven by motivations that the player can subvert. In combination with a unique hacking tool, multiple solutions to puzzles emerge from player choices. Unravel dark conspiracies, defeat a terrifying antagonist in this dramatic, humorous, cyberpunk thriller, which explores contemporary themes: social control, AI, and total surveillance. Intelligent puzzles are interwoven with an intriguing dramatic narrative to deliver a compelling gameplay experience. A beautifully detailed, comic-book styled world, from the mind of legendary comic artist Dave Gibbons.

Thanks, Sigmund!

6/12:A new side-scrolling adventure game has arrived today on Apple Arcade calledLittle Orpheus.

The year is 1962 and NASA are trying to put a man on the moon. In a remote corner of Siberia, a Soviet cosmonaut is heading in the other direction. Comrade Ivan Ivanovich is dropped into an extinct volcano in his exploration capsule, Little Orpheus, to explore the center of the earth. He promptly vanishes.

Three years later he emerges claiming to have saved the world. He has also lost the atomic bomb powering the Little Orpheus. He is taken to a top secret bunker deep below the Ural mountains to be debriefed by the fearsome General Yurkovoi, a man so frightening even Stalin wont buy him a drink. The General rolls up his sleeves, fixes Ivan with a steely glare and say So where have you been comrade? And where is my bomb?And Ivan looks him right back in the eye and says Well General, you might not believe what happened to me, but Ill do my best. Because it happened like this

Join our bold yet hapless hero as he explores lost civilizations, undersea kingdoms, prehistoric jungles and lands beyond imagination. Gasp as he battles the subhuman tribe of the Menkv and escapes the clutches of dreadful monsters! Cheer as he triumphs over impossible odds and brings socialism to the subterranean worlds!

Little Orpheus is a technicolor side-scrolling adventure game inspired by classic movies like Flash Gordon, Sinbad and The Land that Time Forgot. Delivered in eight bite-size, commute-friendly episodes, Little Orpheus is simple enough for casual players but rich enough for seasoned adventure fans.

If youre a fan of old school family blockbusters, want a rollercoaster story thatll take you to the Earths core and beyond, or are just in some need of ideologically correct entertainment, join the most unlikely hero to hit Apple Arcade on an adventure beyond belief. With stunning visuals, brilliant acting and a world-class score, Little Orpheus is a pocket-epic youll never forget.

Comrades, to the center!

6/4:It doesnt look like were getting a new Apple Arcade title this week but there is a major update for the popular RPGOceanhorn 2 with the Golden Edition today (via CNET). The expansion marks a great time to replay the game or jump in for the first time.

Introducing the Golden Edition!

Theres never been a better time to start your RPG adventure or to jump back in! The Golden Edition update is packed with new, exciting content, and its the best version of the game to date!

5/28: Apple Arcade has added a new game from Nickelodeon called SpongeBob: Patty Pursuit. Heres how its described:

Trouble has come to Bikini Bottom! The evil mastermind Sheldon J. Plankton has once again hatched a plan to steal the secret Krabby Patty formula. This time he has enlisted his army of cousins to capture all of SpongeBobs friends! Play as SpongeBob on his epic, most side-scrolly quest through Bikini Bottom ever! Explore, collect coins and spatulas, and crush obstacles as SpongeBob races to rescue his friends, defeat Planktons minions and take back the formula. Keep an eye out for your favorite Bikini Bottom residentsyou never know who you might run into!

5/22:Apple Arcade sees the arrival of a new dungeon crawler RPG,Towers of Everland.

Lets go on a dungeon crawl as Towers of Everland seamlessly brings together exploration, combat and RPG elements to take the player on an amazing adventure within the world of Everland. On your epic journey, test your skills in battle against the hordes of fiendish monsters you encounter, conquer all the towers you can and amass weapons and armor from hundreds of unique pieces.

5/14:Launched today on Apple Arcade is a fun new puzzle journey calledWinding Worlds.

Youre far from home. Youre not sure how you got here. But you do know one thing: its your calling to help your new friends, however you can. But not all of them are being cooperative

From the award-winning studio that brought you GNOG comes Winding Worlds, a finger-wiggling puzzle-adventure about a girl, a Wurm, and how to say goodbye.

Willow just wants to mind her own business. But after she finds a broken magical necklace, she is transported on a spellbinding journey to a network of strange planets, each with a different inhabitant. Hired and guided by a mysterious cosmic Wurm, Willows task is to find out how to help her new friends heal and move on. In Winding Worlds, join a cast of characters, big and small, in a heartwarming tale of grief, love, truth, and acceptance.

5/8:Apple Arcade has gainedThe_Otherside, a new turn-based RPG.

Otherside is a turn based RPG and strategy board game where you will control four survivors who hope to push back the shadowy threat. Make your way through each level solving puzzles, fighting monsters, and destroying the spirit anchors that threaten our dimension.

Do you have what it takes to restore the town back to normal and save the day?

5/1:The latest addition to Apple Arcade is the adventure titleNeversong.

Upon waking from a coma, Peets girlfriend is nowhere to be found. Investigate the screams coming from the heart of Neverwood, the increasingly bizarre behavior of the zombie grownups, and the strange truth about Peets past in this hauntingly dreamlike fable.

From Red Wind Field to the haunting halls of Blackfork Asylum, explore six moody, illustrative levels.

Take on bosses, monsters, and zombie grownups with your trusty baseball bat.

Immerse yourself in a breathtaking piano-centric soundtrack.

Join your quirky childhood pals and trusty pet bird on an adventure to discover the truth about your recent coma.

4/17:Apple Arcade has gained two new titles today with Beyond Blue and A Fold Apart. The former is a deep-sea diving adventure game and the latter is a love story in a paper world puzzler.

Beyond Blue takes you into the near future, where youll have the opportunity to explore the mysteries of our ocean through the eyes of Mirai, a deep sea explorer and scientist. You and your newly-formed research team will use groundbreaking technologies to see, hear, and interact with the ocean in a more meaningful way than has ever been attempted. The game features an evocative narrative, exploration of an untouched world, and adventure that challenges the player to make high-stakes decisions during the crews expedition.

And heres the description ofA Fold Apart.

After career choices force them along separate paths, a Teacher and Architect vow to make their long-distance relationship work at any cost. Experience both sides of their story as the couple navigates the complexities of (mis)communication and the emotional ups and downs that separation brings. By flipping, folding, and unfolding the paper puzzles in their handcrafted worlds, you can help the couple overcome the emotional barriers of their relationship but will love endure?

4/10:The new side-scrollerScrappers is now available on Apple Arcade.

In Scrappers, up to 4 players can team up to clean up the streets of a futuristic city teeming with garbage and trash anyone who gets in their way!

You take on the role of the Scrappers, a squad of robot garbage collectors working to clean up a grimy city of the not-so-distant future. Time is money in Junktown, and team tactics like stacking trash and passing it to teammates much like in basketball can boost your efficiency for bigger rewards!

But garbage collection is only part of the job. Rival teams will attack and interfere, and its up to you to dispose of them while staying on schedule!

Teamwork is key to maximizing efficiency and achieving high scores, which in turn unlocks new characters and customization options!

4/3:Legend of the Sky Fish 2, a new RPG has landed on Apple Arcade.

A hundred years have passed since the hero known as Little Red Hook ended the reign of terror of Skyfish, the Lord of the Deep Seas and now the peace that civilization struggled so much to build is in danger again.

As the last Red Hook guardians, you and your master must use the atypical tool of your clan the Combat Fishing Pole as both a weapon and a grappling hook to face the rising threat.

Unveil an exciting story as you journey in a world full of intriguing characters and devious traps. Explore gorgeous landscapes and mysterious dungeons while defeating mutant abyssal creatures.

3/20: Spyder is out as the latest Apple Arcade title:

Save the world with Agent 8 in this Spy-on-The-Wall adventure.

Set in a retro universe, British Spy Agency EP-8 has created Agent 8, the most sophisticated miniature robot spider on earth! Built using experimental technology, this itsy-bitsy superspy is equipped with all the gadgets and gizmos youll need; cut through panels, overload terminals, flip switches, and open valves as you scurry about sabotaging the heinous plans of evil doers.

3/13: New today is the bouncy dungeon crawlerRoundguard.

Roundguard is a bouncy dungeon crawler with pinball physics, lots of loot, and a randomized castle full of oddballs. Press your luck against hordes of dangerously cute monsters and challenging roguelike elements in this all-round bouncy adventure!

If you love roguelikes & Peggle, then Roundguard is for you.

2/27:The makers of the highly popular Crossy Road are back with Crossy Road Castleas an Apple Arcade exclusive.

Bring your friends and see how far you can get in this endless spinning tower of arcade fun!

Keep climbing as high as you can. Every run is different.

2/14:Apple Arcade gets a new strategy game this week, Loud House: Outta Control from Nickelodeon.

2/7: This weeks new title isCharrua Soccer. It features retro 3D gameplay and features three modes: Friendly Match, Competitions, and Penalty Match.

You can choose player vs computer or player vs player.Charrua Soccerfeatures simple controls with fun and challenging gameplay.

1/31: Secret Oops!has arrived, a multiplayer AR party game.

Secret Oops! is an innovative cooperative local multiplayer Augmented Reality game where players try to make sure that the worlds dumbest spy isnt detected.

1/24: The newest title for Apple Arcade is Butter Royale, a Buttery food fight, battle royale style!

Have the food fight of your life in Butter Royale, a multiplayer battle royale game, and be the last one standing on Butter Island. Play against 31 other players in fastpaced food battles (under 5 minutes) with the help of sauce-shooting, baguette-blasting kichen tools!

1/17:Kings of the Castlehas launched today on Apple Arcade.

Speed to the rescue in this fun, multiplayer fairy tale. Save the prince before anyone else using your iPhone, iPad, Mac, or Apple TV. But watch out for their spells.

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These are the latest Apple Arcade games for iPhone, iPad, iPod touch, Mac, and Apple TV - 9to5Mac

VIDEO: New Trailer Released for Phineas and Ferb The Movie: Candace Against the Universe; Premiering This Month on Disney+ – wdwnt.com

Today, Disney+ shared a newtrailerfor its upcoming out-of-this-world original movie, Phineas and Ferb The Movie: Candace Against the Universe, which premieres on Friday, August 28.

Phineas and Ferb The Movie: Candace Against the Universe is an adventure story that tracksstepbrothers Phineas and Ferb as they set out across the galaxy to rescue theirolder sister Candace, who after being abducted by aliens, finds utopia in a far-off planet, free of pesky littlebrothers.

Voice talent reprising their roles from the original series and movieinclude: Ashley Tisdale as Candace Flynn; Vincent Martella as Phineas Flynn; Caroline Rhea as their mom, Linda; Dee Bradley Baker as Perry the Platypus; Alyson Stoner as Isabella; Maulik Pancholy as Baljeet; Bobby Gaylor as Buford; Olivia Olson as Vanessa Doofenshmirtz; Tyler Mann as Carl; and Povenmire and Marsh as Dr. Heinz Doofenshmirtz and Major Monogram, respectively. David Errigo Jr. joins the cast as Ferb Fletcher

Disney+ is the dedicated streaming home for movies and shows from Disney, Pixar, Marvel, Star Wars, National Geographic, and more. As part of Disneys Direct-to-Consumer and International (DTCI) segment, Disney+ is available on most internet-connected devices and offers commercial-free programming with a variety of original feature-length films, documentaries, live-action and animated series, and short-form content. Alongside unprecedented access to Disneys incredible library of film and television entertainment, the service is also the exclusive streaming home for the latest releases from The Walt Disney Studios. Disney+ is available as part of a bundle offer that gives subscribers access to Disney+, Hulu (ad-supported), and ESPN+. Visit DisneyPlus.com to subscribe and/or learn more about the service.

If you cant wait, you can check out the single, Such a Beautiful Day, from the movie. Let us know in the comments if youre excited to see this new movie coming soon to Disney+.

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VIDEO: New Trailer Released for Phineas and Ferb The Movie: Candace Against the Universe; Premiering This Month on Disney+ - wdwnt.com

Return of an extremely elongated cloud on Mars – EarthSky

View larger. | The Mars Express orbiter, which has been studying Mars for the past 16 years, captured these images of a strange, very elongated cloud on Mars on July 17 and 19, 2020. The cloud can reach up to 1,100 miles (1,800 km) in length. Image via ESA.

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For the past couple of years, the Mars Express orbiter of the European Space Agency (ESA) has been keeping an eye on a mysteriously long, thin cloud that periodically shows up over Arsia Mons, the 12-mile-high (20-km-high) volcano on Mars.

In a July 29 statement, ESA said the cloud has appeared again, illustrated by the images above, acquired by the Visual Monitoring Camera (VMC) on Mars Express on July 17 and 19, 2020.

Mars Express first noticed and photographed the cloud in September 2018. A recurrent feature, the cloud is made up of water and ice and can stretch for over 1,100 miles (1,800 km). Despite its location and appearance, scientists say its not a plume linked to volcanic activity. Instead, the curious stream forms as airflow, influenced by the volcanos leeward slope (the side that does not face the wind).

Jorge Hernndez-Bernal, at the University of the Basque Country (Spain), is leader of a team studying the cloud. He said in a statement:

We have been investigating this intriguing phenomenon and were expecting to see such a cloud form around now. This elongated cloud forms every Martian year during this season around the southern solstice, and repeats for 80 days or even more, following a rapid daily cycle. However, we dont know yet if the clouds are always quite this impressive.

A Martian day, or sol, is slightly longer than an Earth day at 24 hours, 39 minutes and 35 seconds long. A Martian year consists of 668 sols approximately 687 days so the seasons last for twice as long. The southern solstice is the period of the year when the sun is in the southernmost position in the Martian skies, just like the December 21-22 solstice here on Earth. In the early mornings during this period, this fleeting cloud grows for about three hours, quickly disappearing again just a few hours later.

Most spacecraft in orbit around Mars tend to observe in the Martian afternoon. However, Mars Express is in a position to gather and provide crucial information on this unique effect. Mars Express mission team member Eleni Ravanis works specifically for the VMC instrument. She said:

The extent of this huge cloud cant be seen if your camera only has a narrow field of view, or if youre only observing in the afternoon. Luckily for Mars Express, the highly elliptical orbit of the spacecraft, coupled with the wide field of view of the VMC instrument, lets us take pictures covering a wide area of the planet in the early morning. That means we can catch it!

The Mars Express science team has named the cloud the Arsia Mons Elongated Cloud, AMEC. So, how long has it been disappearing and reappearing? Why does it only form in the early morning? Scientists continue to investigate.

Bottom line: Images from the Mars Express spacecraft show that a mysteriously long, thin cloud has again appeared over the Arsia Mons volcano on Mars.

Via ESA

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Return of an extremely elongated cloud on Mars - EarthSky

Coronavirus Live Updates: Latest News and Analysis – The New York Times

A C.D.C. report on children shows hundreds were sent to intensive care for a syndrome connected to Covid-19.

Hundreds of children in America, most of them previously healthy, have experienced an inflammatory syndrome associated with Covid-19, and most became so ill that they needed intensive care, according to a new report from the Centers for Disease Control and Prevention.

The syndrome, which can be deadly, has rattled parents and education officials as schools across the United States struggle with the prospect of reopening in the fall and the coronavirus continues its spread.

The researchers said that from early March to late July, the C.D.C. received reports of 570 young people ranging from infants to age 20 who met the definition of the new condition, called Multisystem Inflammatory Syndrome in Children or MIS-C. The reports came from health departments in 40 states, as well as New York City and Washington, D.C.

The patients were disproportionately people of color, echoing a pattern in adults who have been struck by the respiratory disease caused by the virus. About 40 percent were Hispanic or Latino, 33 percent were Black, and 13 percent were white, the report said. The median age was 8. About 25 percent of the patients had obesity before becoming sick.

MIS-C was first recognized in May as a condition linked to Covid-19 that appears to occur in children and young people who often had not developed any of the respiratory symptoms that are the primary way the virus attacks adults.

The syndrome, which can include a fever, rash, pinkeye, stomach distress, confusion, bluish lips, muscle weakness, racing heart rate and cardiac shock, appears to emerge days or weeks after the initial viral infection, and experts believe it may be the result of a revved-up immune system response to defeating the viruss first assault.

The C.D.C. reported that about two-thirds of the patients had no previous underlying medical conditions, and most experienced complications that involved four or more organ systems, especially the heart. Ten died. Nearly two-thirds were admitted to intensive care units for a median of five days.

Crisis negotiations between the White House and top Democrats teetered on the brink of collapse on Friday, as both sides said they remained deeply divided on an economic recovery package and President Trump indicated that he was prepared to act on his own to provide relief, although it was unclear whether he has the authority to do so.

At a news conference on Friday evening at his golf resort in Bedminster, N.J., Mr. Trump said that if an aid agreement with congressional Democrats could not be reached, he would sign executive orders reinstating a national moratorium on evictions, deferring student loan interest and payments until further notice, and enhancing unemployment benefits through the end of the year.

He also said he would defer payroll taxes, retroactive from July 1 through the end of the year.

The president did not specify how the deferral would work, and it was unclear whether he had the authority to take such an action without approval from Congress. The move, which would not help unemployed workers, faces opposition from both Democrats and Republicans in Congress.

The news conference came after a meeting between administration officials and Democratic leaders that ended with no agreement and no additional talks scheduled.

Democrats, who had earlier said they would be willing to lower their spending demands to $2 trillion from $3.4 trillion, said the White House needed to return with a higher overall price tag after Mr. Trumps negotiators declined to accept that offer. Republicans have proposed a $1 trillion plan.

Treasury Secretary Steven Mnuchin and Mark Meadows, the White House chief of staff, called for Democrats to lower the amount of aid for state and local governments and to provide more specifics on how they proposed to revive lapsed unemployment benefits.

While the executive orders have not been finalized, Mr. Meadows said it was likely that action would come over the weekend.

The blockaded Gaza Strip might be one of the only places in the world where no cases of community transmission of the coronavirus have been recorded a phenomenon attributed to the coastal enclaves isolation as well as to swift measures taken by its militant Hamas rulers.

But the pandemic has not left Gaza untouched.

Citing a need to combat the virus, the authorities that control Gazas borders have imposed new restrictions on movement outside the territory. That has exacerbated an already challenging situation for Palestinians who say they urgently need to travel to Israel and the West Bank.

In March, fearing an outbreak in Gaza, the Hamas authorities ordered all travelers returning to the territory by way of Israel and Egypt to enter quarantine facilities for three weeks. They could not leave quarantine until they had passed two virus tests.

The system seems to have succeeded. All 78 known infections in the territory were detected at quarantine facilities.

Still, experts did not rule out the possibility of the pandemic penetrating into the areas densely populated cities and towns.

All it takes is one small mistake, said Gerald Rockenschaub, the head of the World Health Organizations mission to the Palestinians. Theres no guarantee the virus wont get inside.

Mr. Rockenschaub warned that Gaza lacked the resources to deal with a widespread outbreak, noting that medical institutions had only about 100 adult ventilators, most of which were already in use.

Before the coronavirus hobbled the U.S. economy, many low-wage workers were already struggling to make ends meet.

After mass layoffs and a deep recession followed in the early months of the pandemic, millions of workers found themselves faced with evictions, late car payments, and crushing medical bills. For many, the main solace through the worst months of the crisis was a broad range of stimulus measures, including $600 per week in extra unemployment benefits.

But with those measures expiring, and no clear indication of whether new ones will replace them, many unemployed workers now find themselves in limbo, struggling to find work in an economy that remains significantly weakened.

Eviction moratoriums are expiring or have expired in much of the country, and a report released Friday warned that 30 million to 40 million tenants risk losing their homes in the coming months. The Paycheck Protection Program, which helped thousands of small businesses to retain workers, also ends this week.

Research from the last recession found that when unemployment benefits ran out, people cut their spending on food, medicine and other necessities, suggesting they were able to do little to prepare for the drop in income.

While wealthier families may be able to draw on savings to get by until Congress strikes a deal to prolong the stimulus, lower-income households face serious long-term consequences from even a temporary lapse in income. An eviction can make it hard to rent in the future. Having a car repossessed can make it hard to find another job. And for children, periods of hunger, homelessness and stress can have long-term effects on development and learning.

While the U.S. economy has slowly added back some jobs that vanished at the beginning of the pandemic, the unemployment rate still stands at over 10 percent. For those who may not return to work for some time, the loss of protections has only added to uncertainty about the future.

New Yorkers, by and large, have adhered to rules mandating social distancing and mask wearing. The diligence has helped keep the coronavirus under control in the city even as outbreaks have raged across the United States, primarily in the South and the West.

As the summer wears on, however, mounting reports of parties, concerts and other social events, like a recent rave under the Kosciuszko Bridge, are raising fears that New Yorks hard-earned stability may be tenuous.

Over the last few weeks, videos and photos posted on social media have shown densely packed, mask-free crowds.

Its illegal, Gov. Andrew M. Cuomo said at a recent news conference, referring to the partying. It not only violates public health, but it violates human decency.

The images contrast sharply with the memories of a brutal spring in New York that left tens of thousands dead, disproportionately ravaging low-income communities and neighborhoods with high numbers of Black and Latino people.

Illegal raves are growing in popularity in Europe, including in Berlin, in London and near Paris, as coronavirus lockdowns are eased across the continent but most nightclubs remain closed.

Outdoor events for hundreds in some cases, thousands organized via social media and messaging apps, are in full swing each weekend, causing headaches for police forces and lawmakers, and stirring public debate and news media panic.

Worries that nightlife activity would fuel the spread of the virus have in the meantime led Curaao, the Caribbean island, to close its bars and clubs for at least two weeks since Friday, according to the Dutch newswire ANP. The nearby island Aruba was reported to have almost 300 confirmed cases over the last five days.

When a coronavirus lockdown sealed Myanmars borders in March, the tourism industry was devastated, even if the country was spared from disease.

Now, in the hill town of Pyin Oo Lwin, owners of horse carts that used to clip-clop through streets laden with visitors are sending their animals to slaughterhouses because they can no longer afford to keep them alive.

I feel sad about selling the horse, because he is like a family member, said U Maung Win, a horse cart owner. He worked so hard to save our lives, and I could not save his life.

For months now, no tourists have come to ride through the town, with its cool breezes and pretty gardens, Mr. Maung Win said, but the horses still needed to be fed, at a cost of a couple dollars a day. The slaughterhouses paid about $500 per animal.

Mr. Maung Win, who supports a family of six, now works as a mason and is paid less than $10 a week.

Its better than nothing, he said.

With his horse and a cart painted like a fairy-tale stagecoach, Mr. Maung Win could pull in $10 in a single day, delivering tourists to the botanical gardens or cafes offering fresh strawberries. Couples posed for wedding pictures in the carriages, holding the bell-adorned reins in their intertwined hands.

Two-thirds of the 100 or so horse carts in town are now gone, Mr. Maung Win said.

I tried not to sell the horse to the slaughterhouse, but I had no choice, he said. I still feel sad talking about this.

Lucky friends, he said, had two horses. But he owned only one.

Of all the missteps by governments during the pandemic, few have had such an immediate and devastating impact as the failure to protect nursing homes. Tens of thousands of older people have died casualties not only of the virus, but of more than a decade of ignored warnings that nursing homes were vulnerable.

Public health officials around the world excluded nursing homes from their pandemic preparedness plans and omitted residents from the mathematical models used to guide their responses.

In recent months, as the United States has blundered its way into the worlds largest death toll, about 40 percent of those fatalities have been linked to long-term care centers. Yet European countries still lead the world in deaths per capita, in part because of what happened inside their nursing homes.

Spanish prosecutors are investigating cases in which residents were abandoned to die. In Sweden, overwhelmed emergency doctors have acknowledged turning away elderly patients. In Britain, the government ordered thousands of older hospital patients including some with Covid-19 back to nursing homes to make room for an expected crush of virus cases. (Similar policies were in effect in some U.S. states.)

The response in Belgium has offered a gruesome twist: Paramedics and hospitals sometimes flatly denied care to elderly people, even as hospital beds sat unused.

Paramedics had been instructed by their referral hospital not to take patients over a certain age, often 75 but sometimes as low as 65, the charity Doctors Without Borders said in a July report.

More than 5,700 residents of nursing homes in the country have died, according to newly published data. During the peak of the crisis, from March through mid-May, residents accounted for two out of every three coronavirus deaths.

The riskiest window for such transmission may be extremely brief a one- to two-day period in the week or so after a person is infected, when coronavirus levels are at their highest, according to Dr. Joshua Schiffer, a physician and mathematical modeling expert who studies infectious diseases at the Fred Hutchinson Cancer Research Center in Seattle. He is one of the authors of the paper.

The virus can still spread outside this window, and people outside it should not let up on measures like mask-wearing and physical distancing, Dr. Schiffer said. But the longer an infection lasts, the less likely a person is to be contagious a finding that might help experts advise when to end self-isolation.

It really is about opportunity, said Shweta Bansal, an infectious disease ecologist at Georgetown University who was not involved in the study. These processes really come together when you are not only infected, but you also dont know youre infected because you dont feel crummy.

Reporting was contributed by Iyad Abuheweila, Matt Apuzzo, Hannah Beech, Pam Belluck, Conor Dougherty, Alex Marshall, Constant Mheut, Claire Moses, Monika Pronczuk, Adam Rasgon, Thomas Rogers, Matina Stevis-Gridneff, Katherine J. Wu and Mihir Zaveri.

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Coronavirus Live Updates: Latest News and Analysis - The New York Times

Americans are moving around too much and taking coronavirus with them, expert says – CNN

In list ranking countries response to the pandemic assessed by Foreign Policy Magazine, the United States ranks near the bottom.

"If you look at the mobility data collected from cell phones in many parts of the country, we're almost back to pre-Covid levels of mobility, so we're just not being as cautious as other people are in other countries," Murray told CNN's Wolf Blitzer on Friday.

"Number one, wash your hands. Number two, watch your distance -- meaning stay at least six feet from others and avoid crowded places. And number three, wear a face mask," Adams said.

Rethinking testing

One important factor to reopening the US while maintaining safety is rethinking the national strategy on testing for the virus, said Dr. Rajiv Shah, president of the Rockefeller Foundation and former USAID administrator.

Currently, only symptomatic people are frequently tested, meaning 40% to 50% of all spreaders, those who don't show symptoms, aren't being tested and told they may be contagious, he said.

"You have to know that as soon as possible, and then limit transmission from that node of contagion," he said during an Aspen Ideas webinar on Friday. "That's the whole ball game."

But even testing primarily symptomatic people been impacted by backlog, many states report.

The Virginia Department of Health reported a sharp increase of cases on Friday, but that increase came from a technical issue and a backlog from the two days prior, according to a statement.

And Miami-Dade County, the hotspot for cases in Florida, continues to struggle with a lag in testing results, according to state data obtained by CNN.

One day in the past week, testing labs reported that 19.2% of test results took more than seven days to deliver. On a different day, 45% of test results took between four and seven days.

Precautions matter for children, too

As schools reopen for the new school year, researchers are learning more about how the virus spreads among children.

A new report from the Centers for Disease Control and Prevention supports the early belief that most coronavirus cases in children appear to be either asymptomatic or mild. But, the report said, when children are hospitalized, they need the intensive care unit as often as adults do.

To slow the pandemic, the CDC said children should be encouraged to wash their hands often, keep a good physical distance away from others, and if they are 2 years of age or older, they should wear a mask when they are around people outside of their family members.

One rare but serious complication children can develop from a coronavirus infection is known as multisystem inflammatory syndrome, or MIS-C, and at least 570 cases have been reported, the CDC said.

As the pandemic continues, health care providers should be on the lookout for the syndrome that most commonly causes abdominal pain, vomiting and a skin rash.

More than 74% of the cases were among Hispanic and Black children, the CDC said.

Pandemic highlights racial disparities

For communities of color, Covid-19 has been a "double whammy" that shows the work the US needs to do to correct disparities in health and health care, Dr. Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases, said on Friday.

For example, Black Americans are more likely to have jobs that are considered essential, Fauci said, which leads to a much greater risk of being infected.

"Then there's the other thing that is really the chronic and decades-old dilemma of the social determinants of health, which is why African Americans have a higher degree of diabetes, of hypertension, of obesity, of heart disease, of chronic lung disease, of kidney disease," Fauci said. "That does not need to be. But to get corrected, you have to make a decades-long commitment to change that."

Part of that commitment has to include making resources like immediate testing and results as well as access to health care concentrated in demographics at higher risk of infection.

Trials for vaccines for Operation Warp Speed will be inclusive and diverse, chief adviser Moncef Slaoui said Friday. And once it is complete, he said they will be distributed widely.

"We are extremely cognizant of the importance of making sure that the vaccines, if and when they become available, are appropriately allocated in the population, on the basis of data ... and on the basis of need," he said.

CNN's Lauren Mascarenhas, Rebekah Riess, Gisela Crespo, Naomi Thomas, Jen Christensen and Rosa Flores contributed to this report.

Originally posted here:

Americans are moving around too much and taking coronavirus with them, expert says - CNN

One man with coronavirus attending Ohio church service led to infection of 91 others – NBC News

A 56-year-old man with the coronavirus attending a single church service in Ohio led to the infection's spread to at least 91 other people across five counties.

Gov. Mike DeWine posted a graphic to his Facebook page Wednesday detailing how the virus spread over a three-week period from the date of the church service on June 14 to July 4.

"It spread like wildfire," the governor said at a news conference Tuesday where the graphic was displayed. "Very, very scary."

"We have been very careful throughout this pandemic to exempt religious services from any regulations," the governor said. "The only exception to that is that we are now asking people who attend church to wear a mask."

He noted on his Facebook page that while this case of community transmission stems from a church, it can happen anywhere

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"All it takes is one person to cause tremendous #COVID19 spread," he wrote.

After the man with the coronavirus went to the church service in Ohio County in June, 53 others who had been at the same service became infected, according to the graphic shared by DeWine.

Eighteen of the these 53 spread the virus to at least one other person, the graphic shows. The man's wife, a son and a daughter also got sick.

All 91 others infected after the service showed symptoms of COVID-19, the disease caused by the coronavirus, the governor said.

DeWine in a series of tweets on Tuesday also provided other examples of the virus' spread within family and friend groups.

In one case, a son living with his father who was in hospice care developed a cough and believed he had bronchitis. Family members came to visit to pay respects to his father. Five family members later tested positive for the virus, including a great-nephew, the governor said.

Separately, a man who had COVID-19 symptoms attended his brother's wedding and reception. Now, 15 people are sick, including the bride, groom and one of their grandfathers.

And in another outbreak, a person who tested positive for the virus attended a bridal shower, leading to others becoming infected. "There are now six confirmed cases and six households impacted by this outbreak," DeWine said.

"None of us want to stay away from our families and of course, it's natural to want to show affection when you see them," he tweeted Tuesday. But this virus is "lurking," he wrote. "Please try to remember that you are showing love by protecting them."

Rachel Feeley, a spokeswoman for the Ohio Department of Health, declined on Thursday to release the name of the church where the virus spread or any details on the other cases. "We are not releasing additional information about these examples to the general public, in order to protect private health information," she said.

Feeley said that anyone who may have come into contact with people who had tested positive in these examples were notified through normal contact-tracing protocol.

On Thursday, DeWine's office said in a statement that he had tested positive for the coronavirus, but later said a second test, a PCR test, came back negative. The governor will be tested again Saturday.

Janelle Griffith is a breaking news reporter for NBC News.

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One man with coronavirus attending Ohio church service led to infection of 91 others - NBC News

With Old Allies Turning Against Her, Birx Presses On Against the Coronavirus – The New York Times

From her office in the West Wing, Dr. Birx serves as a link between federal agencies the Departments of Defense, Homeland Security, Health and Human Services, and others engaged in the response.

She is also the point of contact for state and local officials, and oversees the drafting of detailed reports offering guidance to the states. She briefs Mr. Pence weekly and the president at least once a week, and must contend with competing forces on the task force, which includes Dr. Anthony S. Fauci, the governments top infectious disease expert, and Dr. Robert R. Redfield, the C.D.C. director. She is often the only woman in the room.

In interviews with AIDS activists and public health experts, Dr. Birx drew unfavorable comparisons with the outspoken Dr. Fauci, in whose lab she trained. Mr. Gonsalves, who has long known both of them, said he wrote in March to Drs. Birx, Fauci and Redfield, as well as Adm. Brett P. Giroir, who oversees coronavirus testing, complaining that they were parroting the president. Only Dr. Fauci replied.

Debbie is now in the position where shes saying to the emperor that those new clothes look fantastic, Mr. Gonsalves said.

But inside the White House, aides refer to Dr. Birx as Dr. Doom for her efforts to temper the presidents positive spin. And she and Dr. Fauci are not in the same situation. Dr. Fauci, 79, is nearing the end of his career and is a civil servant, which frees him to speak his mind. Dr. Birx, 64, is a political appointee who serves at the pleasure of the president.

Shes one of the hardest workers, and shes devoted to trying to get this pandemic under control, Dr. Fauci said in an interview Tuesday night.

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With Old Allies Turning Against Her, Birx Presses On Against the Coronavirus - The New York Times

This Week in Coronavirus: July 31 to August 6 – Kaiser Family Foundation

EveryFridaywerecap thepast week inthe coronaviruspandemicfrom our tracking, policy analysis, polling, and journalism.

The United States remains among the worlds leaders in daily new case reports as the countrys total cases approaches 5 million with over 160,000 deaths. In the midst of this reality, the school year is beginning across the country with decisions about in-person attendance versus virtual learning continuing to roll in. The total number of deaths per day are now over 1000, reaching 1500 and 1800 on Tuesday and Wednesday, respectively.

As cases continue to climb, this weeks Chart of the Week compares the United States per capita case rate to those of other countries that have opened their schools for in-person attendance and finds a big disparity with the United States having a much higher rate of community spread.

Most parents prefer opening schools later to reduce the risk of coronavirus transmission, with two-thirds of mothers and half of fathers preferring such delays. Some members of KFFs polling team wrote about this gender gap and how mothers are reporting more strain due to stress from the pandemic.

Global Cases and Deaths:Totalcases worldwide approached 20millionbetweenJuly 30 and August 6 withan increase ofapproximately1.8millionnew confirmed cases.There werealsoapproximately40,800new confirmed deaths worldwide during the period, bringing the total to nearly 715,000confirmed deaths.

U.S. Cases and Deaths:Total confirmed cases in the U.S. approached 5 million this week.Therewas anapproximateincrease of 388,600confirmed cases betweenJuly 31andAugust 6.About 7,300confirmed deaths in the past week brought the total toover160,000confirmed deaths in the U.S.

Race/Ethnicity Data:Black individuals made up a higher share of cases/deaths compared to their share of the population in32of 49states reporting cases and33 of 44states reporting deaths as of August 3.In 7 states (MI, TN, MO, IL, KS and ME) the share of COVID-19 related deaths among Black people was at least two times higher than their share of the total population.

Hispanic individuals made up a higher share of cases compared to their share of the total population in 35 of 46 states reporting cases. In 6 states (NE, WI, IA, MN, TN, and SD), Hispanic peoples share of cases was more than 3 times their share of the population. COVID-19 continues to have a sharp, disproportionate impact on American Indian/Alaska Native as well as Asian people in some states.

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This Week in Coronavirus: July 31 to August 6 - Kaiser Family Foundation

St. Louis Cardinals have another series postponed because of positive coronavirus tests – CNN

Major League Baseball had announced the postponement of Friday's contest to allow for additional testing and to complete the "contact tracing process" after one player tested positive.

In a second statement, MLB said the other two games of the series at St. Louis were postponed "out of an abundance of caution." MLB said two players and a staffer had samples that yielded positive results for the virus.

The Cardinals were cleared by MLB to travel home from Milwaukee earlier this week following a team outbreak that saw seven players and six staff members test positive for the virus.

The team has not played since July 29. Series against the Milwaukee Brewers and Detroit Tigers were postponed.

It appears the Cardinals may have been the only one of 30 teams that had positive tests during the seven-day period that ended Thursday,

Earlier Friday MLB announced it has received 13 positive tests in that time. Seven of the positive results came from players, and six came from team staffers, it said.

So far, MLB has done more than 57,000 tests, of which 141 resulted in new positives. All but two organizations have had a person test positive since testing began.

Several other teams have had games postponed. The Miami Marlins went a week without games after more than 20 people on the team tested positive in July. They have called up 11 players in the past week from their training center and they have signed several free agents.

CNN's Jill Martin and Jabari Jackson contributed to this report.

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St. Louis Cardinals have another series postponed because of positive coronavirus tests - CNN

At Europes Illegal Parties, Coronavirus Is the Last Thing on Anyones Mind – The New York Times

Some party organizers have tried to respond to public concern: Covid-19 measure been taken, said a message in the WhatsApp group about Fridays event. A station at the entry will be at your disposition with facial mask and hydro alcoholic gel, it added. These were not in evidence on arrival, and only a dozen or so attendees wore masks. For most, the coronavirus seemed far from their minds.

Dancers were packed tightly in front of a D.J. In the middle of the improvised dance floor, a tall man stood with his eyes closed, moving his arms like a birds wings, transported by the music. People chatted to each other for a moment, then hugged, instant friends. Occasionally a balloon drifted above the dance floor, filled with nitrous oxide, the partys drug of choice.

One attendee, a 25-year-old architect who asked not to be named in case he was thrown out of the WhatsApp group, said hed been going to illegal raves for a couple of years. Last year, it was smaller, he said. Everybody just wants to get out now, I suppose.

Pubs and restaurants in Britain had reopened, he added, but no one in authority was thinking about dance-music culture. He would have thought twice about going to an indoor or boat party, he said, but outdoor ones seemed fine.

As the night went on, more people arrived, even a man on crutches. Someone climbed a tree at one point, and the music stopped while a security guard ordered him down. That was the closest the event came to an incident until, around 4 a.m., three police officers turned up, shining flashlights across the crowd.

They left as quickly as they arrived, but their presence was enough to send some home.

About 20 minutes later, the police returned 20 officers this time and stood in the path to the clearing. One officer said theyd agreed with the D.J. that he could keep playing until 4:30 a.m.

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At Europes Illegal Parties, Coronavirus Is the Last Thing on Anyones Mind - The New York Times

The Roach Unit is the only Texas prison reporting zero coronavirus cases – The Texas Tribune

Need to stay updated on coronavirus news in Texas? Our evening roundup will help you stay on top of the day's latest updates. Sign up here.

The only Texas prison that hasnt had any staff or inmates test positive for the new coronavirus is the same one where inmates make soap and package hand sanitizer for the states lockups. Prisoners arent allowed to use the latter.

How this one unit seemingly remains untouched by a virus that has ravaged the states prison system, however, has been credited not to its soap factory, but to the prisons location and the wardens strict enforcement of the Texas Department of Criminal Justices coronavirus policy. Meanwhile, those inside prisons with hundreds of infected inmates have long reported dangerous practices. In lawsuits and letters, they have described officers without face masks, forced intermingling between infected and healthy prisoners, and limits to soap and cleaning supplies.

Texas leads the nation in prison deaths connected to the coronavirus, with a higher death toll than the federal lockups or any other state prison system. At least 112 Texas prisoners and 16 people who worked in prison units have died with the virus.

The Roach Unit is one of Texas more than 100 state-run prisons and jails, housing about 1,300 incarcerated men in the rural town of Childress in the Texas Panhandle. But none of the more than 17,700 state inmates who have tested positive for the virus were housed at Roach, according to a prison spokesperson. Nor have any of the nearly 3,700 infected prison employees worked at the unit.

Weve been lucky so far that here in the community of Childress there hasnt been a big number of coronavirus cases, said Ricardo Gutierrez, a 36-year-old inmate at the Roach Unit, in response to questions sent by The Texas Tribune. I think that helps out a lot to not get the staff infected.

After inmate visitation was canceled statewide, and most prison system transfers and all intake from county jails were temporarily halted in March and April, epidemiologists said most new prison infections were likely coming in through prison employees who contracted the virus in their communities. Childress County, with a population of about 7,000, has had only 37 people test positive for the coronavirus, according to data from the state health department.

TDCJ spokesperson Jeremy Desel said being geographically isolated helps protect the unit from the virus, but he added there is still significant traffic there for distribution of materials they produce.

In a March promotional video, TDCJ highlighted the Roach Units soap and detergent factory as an essential tool to protect against the coronavirus, showing factory machines and some of the 84 inmates who work without pay to produce things like bar soap, laundry detergent, dish soap and bleach to distribute throughout the Texas prison system and sell. Soap? We have plenty! the video title boasted.

The top way to help stop COVID-19 is simple! Wash your hands!The Centers for Disease Control says to vigorously wash your hands with soap and water for at least 20 seconds often. Soap? We have plenty!Not just a stock pile, TDCJ produces soap that is made at the Roach Unit daily. #tdcj #washhands #RoachUnit

The next month, inmates in the factory also began repackaging hand sanitizer for prison employees to use, Desel said. TDCJ has steadfastly refused to allow inmates access to hand sanitizer, part of what prompted a federal lawsuit and four-week trial scrutinizing TDCJs handling of the pandemic. Prison attorneys have argued inmates could get drunk from the hand sanitizer or use it as an accelerant to set fires. Inmates attorneys have rejected those premises, saying such abuses are rare in lockups that allow it.

Aside from its location, though, Desel said Roach is doing the same things that all units are doing to stop COVID. But prisoners tell a different story.

Since March, inmates at numerous other prisons have told their loved ones and the Tribune that staff members have only partially enforced the policies put in place by prison officials to wear masks, regularly sanitize, and stay a safe distance apart in places like dorms, showers and hallways. Many inmates have reported that officers wore masks pulled down to their chins, prisoners were taken to the showers in large groups, and inmates who tested positive for the virus were sometimes housed with those who tested negative.

But at Roach, Gutierrez said the staff are not messing around. He said in a few instances where coronavirus was suspected, the sick inmate would be promptly removed and tested, and the men on the wing the inmate lived in would be quarantined for a few days until the tests came back negative, with nurses in protective gear regularly checking them for symptoms.

Theyre doing everything that the government has mandated: social distancing, the masks, sanitizing everything, he said. This warden has gone above and beyond to make sure that everything is being done right.

Gutierrez said he gets the typical weekly amount of soap five small bars stuffed into a toilet paper roll on Friday. But since the pandemic hit the state, he said Roach inmates also get more soap and a surface cleaner every Tuesday, and more is available at lunch in the dining hall. He said inmates also were still able to go to recreation and go to common rooms, but in much smaller groups.

Michele Deitch, a senior lecturer and prison conditions expert at the University of Texas' LBJ School of Public Affairs and law school, said Gutierrezs description could make the Roach Unit a powerful example of the ways in which following TDCJ policies can help prevent an outbreak. On Thursday, 20 TDCJ lockups each had more than 300 inmates who had tested positive for the virus, with active infections often reported in large clusters of hundreds of people at once. Three units housed more than 700 inmates who had tested positive.

The official protocols may be the same throughout the system, but ultimately there are huge differences in the degree to which particular facilities are following those protocols, she said. If they are taking the steps that they should be taking, they can reduce the spread of it within the facility if it does come in it doesnt have to become like a spread of wildfire.

The University of Texas at Austin's LBJ School of Public Affairs has been a financial supporter of The Texas Tribune, a nonprofit, nonpartisan news organization that is funded in part by donations from members, foundations and corporate sponsors. Financial supporters play no role in the Tribune's journalism. Find a complete list of them here.

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The Roach Unit is the only Texas prison reporting zero coronavirus cases - The Texas Tribune

Coronavirus in Oregon: 423 new infections and 9 deaths – oregonlive.com

Oregons new coronavirus case count exceeded 400 for the first time this month, with state authorities announcing 423 new cases and nine new deaths Friday.

Multnomah County saw one of its highest new confirmed and presumed case totals, reporting over 100 new cases for only the fourth time since the pandemic began. The percent of statewide tests to come back positive also surpassed 7%, marking one of the few times thats happened in recent months.

The numbers come even as state health officials found a relative flat-line in the spread of the disease, with each infected person infecting, on average, one other person. At current infection rates, Oregon Health Authority officials expect to see 1,000 new cases per day through late August, though only a fraction of those would be identified.

Where the new cases are by county: Baker (1), Benton (3), Clackamas (16), Clatsop (1), Columbia (2), Deschutes (18), Douglas (3), Grant (1), Hood River (3), Jackson (12), Jefferson (5), Josephine (3), Klamath (1), Lane (13), Lincoln (1), Linn (6), Malheur (21), Marion (47), Morrow (21), Multnomah (110), Polk (7), Umatilla (53), Union (2), Wasco (3), Washington (53) and Yamhill (17).

New fatalities: Oregons 340th death linked to coronavirus is a 90-year-old Clackamas County man with underlying medical conditions. He tested positive July 30 and died Aug. 5. State officials are confirming where he died.

Oregons 341st death is an 80-year-old Deschutes County woman. She tested positive July 20 and died July 31. State officials are confirming where she died and whether she had underlying medical conditions.

Oregons 342nd death is an 80-year-old Jackson County man with underlying medical conditions. He tested positive July 15 and died Aug. 6. State officials are confirming where he died.

Oregons 343rd death is a 75-year-old Jefferson County man with underlying medical conditions. He tested positive July 10 and died Aug. 5 at St. Charles Medical Center in Bend.

Oregons 344th death is a 64-year-old Klamath County man with underlying medical conditions. He tested positive July 27 and died Aug. 6 at Sky Lakes Medical Center in Klamath Falls.

Oregons 345th death is an 88-year-old Malheur County man who tested positive July 28 and died Aug. 2 in his residence. State officials are confirmed if the man had underlying medical conditions.

Oregons 346th death is a 75-year-old Marion County man with underlying medical conditions who tested positive July 8 and died Aug. 5 in his home.

Oregons 347th death is 94-year-old Umatilla County man with underlying medical conditions. He tested positive July 16 and died Aug. 4 in his home.

Oregons 348th death is a 93-year-old Yamhill County woman who tested positive July 28 and died Aug. 6. State officials are confirming where she died and whether she had underlying medical conditions.

The prevalence of infections: State officials Thursday reported 400 new confirmed infections out of 5,420 people tested, equaling a 7.4% positivity rate.

Who got infected: State officials reported new confirmed or presumed infections among the following age groups: 0-9 (28); 10-19 (51); 20-29 (78); 30-39 (78); 40-49 (53); 50-59 (57); 60-69 (35); 70-79 (15); 80 and older (18).

Whos in the hospital: The state Friday reported 145 Oregonians with confirmed coronavirus infections are currently in the hospital, down eight from Thursday. Oregon remains well below its capacity, with hundreds of hospital beds and ventilators available.

Since it began: Oregon has reported 20,636 confirmed or presumed infections and 348 deaths, among the lowest totals in the nation. To date, 436,619 Oregonians have been tested.

Mark Friesen contributed to this report.

-- Fedor Zarkhin

fzarkhin@oregonian.com|503-294-7674

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Coronavirus in Oregon: 423 new infections and 9 deaths - oregonlive.com

Suspension Lifted of Georgia Student Who Posted Photos of Crowded Hall – The New York Times

The widely circulated photo from North Paulding High School in Dallas, Ga., showed students crowded into a packed hallway on their first day back to classes since the coronavirus outbreak shuttered schools in the spring. Few were wearing masks, and there was little sign of social distancing. Then on Day 2, there was another.

The photos, which were shared on social media and cited in news reports, have quickly come to symbolize a chaotic first week back in U.S. classrooms. Schools in states where students have returned, including Georgia, Mississippi, Tennessee and Indiana, have had to initiate quarantines and in some cases shut down classrooms and entire schools temporarily after positive cases emerged.

A 15-year-old student at North Paulding, Hannah Watters, was initially suspended for five days for posting images of the crowded hallways on Twitter, according to her mother, Lynne Watters, who said she filed a grievance with the school on Thursday.

By Friday, Hannah said, her suspension had been lifted and wiped from her record, with the schools principal calling her mother to tell her that she could return to class on Monday.

Although she agreed that she had breached the schools policy, which prohibits filming students and posting their images to social media without their consent, Hannah said in an interview that she did not regret doing so as the images had shed light on the crowding and lack of social distancing in her school.

My mom has always told me that she wont get mad at us if we get in trouble as long as its good trouble, Hannah said, invoking the famous phrase of Representative John Lewis, the civil rights leader who was laid to rest in Atlanta last week. Youre bettering society and bettering the world, so those consequences dont outweigh the end result.

The high school and school district did not immediately respond to requests for comment.

The superintendent of the Paulding County School District, Brian Otott, had defended his systems reopening plan, saying in a letter to the community after the hallway photos circulated that the scenes were taken out of context. Students only remained in the hallways briefly while switching classes, he wrote, and the school was following recommendations issued by the Georgia Department of Education.

But he acknowledged, There is no question that the photo does not look good.

Masks are not required at the school, Mr. Otott said, though the administration strongly encourages them for students and staff members.

Wearing a mask is a personal choice, and there is no practical way to enforce a mandate to wear them, he wrote, adding that more than 2,000 students attend the high school.

Updated Aug. 7, 2020

The latest highlights as the first students return to U.S. schools.

The districts guidelines say staff members will do their best to require students to maintain social distancing, but note that it would not be possible to enforce social distancing in classrooms or on school buses unless it is a class or a bus with fewer students.

A spokesman for the Georgia Department of Public Healths northwest district, which includes Paulding County, said the agency offers advice about best practices for controlling the spread of the virus, but choices about what to do in schools are ultimately up to local officials.

Each school system makes its own decisions, said the spokesman, Logan Boss, adding that the department does not monitor schools to see if they are complying with its recommendations.

The high school opened for the school year on Monday even though there had already been reports of a coronavirus outbreak among members of the football team. Mr. Boss said he was not aware of students or staff members testing positive at North Paulding High, but he added, Theres widespread community transmission in Paulding County.

For Hannah, her return to class next week will be an anxious one. There is still the worry over the virus, and now also the stress of wondering how other students will respond to her having shared the images of the crowded hallway.

Going back, Im probably going to be just about as nervous as I was the first day of school, she said, adding that she hopes people realize that she posted the pictures to advocate for the safety of everyone in the building.

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Suspension Lifted of Georgia Student Who Posted Photos of Crowded Hall - The New York Times

Medication Used for Alcoholism Treatment Is Potentially Effective Against COVID-19 – SciTechDaily

Problem: Development and trials of new coronavirus treatments may take anywhere from four to seven years. But millions of patients need treatment here and now. Doctors are looking for effective medications (or combinations of medicines), blindfolded. Meanwhile, chemists can predict which existing medications are potentially the most effective.

Solution: Russian researchers have created a special method of molecular modeling called on-top docking. They used it to explore the whole surface of a protein that is vitally important for SARS-CoV-2 and compared it to a number of known medications. They discovered that two drugs are potentially able to switch off the enzyme and stop the coronavirus reproduction. One of them is used to treat alcohol addiction, and the other is for cancer.

A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modeling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. Both drugs are potential covalent inhibitors of the SARS-CoV-2 virus main protease Mpro a key enzyme responsible for SARS-CoV-2 replication (copying its genetic material and building the new virus particles). The paper about the discovery was published in the July issue of Mendeleev Communications journal.

A coronavirus was first detected in a patient with acute respiratory infection long ago, in 1965, but it was only about two decades ago that humanity faced really dangerous representatives of this family. Unfortunately, since the first SARS-CoV epidemic didnt leave Asia (mostly, China) in 2002-2004 and the MERS outbreak in 2012-2015 seriously affected only Saudi Arabia and Korea, the global pharmaceutical industry has made virtually no effort to develop effective treatments for coronaviruses. Tests and medications have been actively developed almost exclusively for the needs of veterinary medicine.

Broad-spectrum medicines were used during previous epidemics, but the experience of medics in Chinese Wuhan demonstrated that this was not enough. Clinicians around the world have risked trying various experimental protocols, with the use of medicines used to treat HIV (lopinavir and ritonavir), malaria (chloroquine and hydroxychloroquine), and other diseases. But they were looking for the drugs being effectively blindfolded.

The global pharmaceutical industry was caught unaware, and there was no time to create brand new medicines. Even if potentially effective substances are detected, their preclinical and clinical trials would take from four to seven years. Thats why the most reasonable solution has been to search among known drugs that have proven to be safe for human health. This path repurposing medicine has been effectively used for a long time. The only problem is: how do we learn whether they are able to fight the coronavirus?

Computer modeling can help. This approach is called in silico similarly to in vivo (in a living body) and in vitro (in a test tube). It allows numerical models to be used to test hundreds of various medications and determine their potential effectiveness and the mechanism of action. Chemists at HSE University and the RAS Zelinsky Institute of Organic Chemistry have been carrying out such research for many years. In 2014, they modeled a leukemia treatment, and in 2017, a treatment for rheumatoid arthritis. With such a background, the researchers jumped into the search for a SARS-CoV-2 treatment in 2020.

The coronavirus, like many other viruses, mutates quite quickly. Its genome contains about 30,000 nucleotides specific building blocks of the genetic code. On average, one mutation, or more precisely, one SNP (single nucleotide polymorphism) happens in a virus RNA once every two weeks. This means that new strains of SARS-CoV-2 appear regularly. In Russia alone, there are nine unique SARS-CoV-2 lineages that are not present in other countries.

This is why the structural elements of the virus that are less subject to mutation during its evolution should be chosen as a target for the potential treatment. Otherwise, a medication effective against one strain would no longer be effective against another. The best candidates for this are conservative proteins, such as theSARS-CoV-2 virus main protease Mpro.In addition to being resistant to mutations, Mproplays a major role in coronavirus replication, which means that its inhibition (blocking its function) is able to slow down or even completely stop its reproduction inside the body.

Usually, the process of docking, as with a port dock and a ship entering it, is used for molecular modeling in simple cases. Two molecules participate in docking. One is called a ligand (here, it is a medicine), and the other one is receptor (or active site) of the target protein, such as Mpro, which can be used to dock. An effective drug docks with the active site, by covalent links, which makes the enzyme dysfunctional or destroys it.

A visualization of docking of a small ligand molecule (blue) with protein receptor (red).

To simulate the docking, researchers need to know the precise spatial structure of the drug molecule (they are available in special databases) and the precise configuration of the target proteins active site. Here, researchers may face the first challenges: there might be dozens or even hundreds of such sites, and they are not fixed in space. Thats why classical docking does not work in SARS-CoV-2.

To overcome this problem, chemists from HSE University and the Zelinsky Institute decided to use on-top docking, which they came up with shortly before the pandemic. They decided not to focus on the previously described active site, but to investigate the whole surface of Mproprotein with many medications, hoping that the big calculation powers would return useful dockings.

The researchers used the spatial model ofSARS-CoV-2 Mprocreated in January 2020 from PDB database (ID 6LU7). The potential drugs were taken from the database of medications approved by the United States Food and Drug Administration (FDA). The research teams own algorithms were used for modeling.

The modeling data demonstrated that sulfur-containing drugs show unusually high ligand efficiency at the active center of SARS-CoV-2 main protease Mpro, but only disulfiram 4 retains stable interactions.

Structure formula of disulfiram.

Today, it is most commonly used for treating alcoholism, since disulfiram inhibits the acetaldehyde dehydrogenase enzyme. As a result, the conversion of ethanol in the liver stops on the stage of acetaldehyde. Its concentration in the body grows, leading to acute intoxication, accompanied by sickness, vomiting and extreme pain. As a result, alcohol addicts acquire a conditioned reflex of disgust to the smell and taste of alcohol-containing drinks. This means that if the effectiveness of disulfiram against the novel coronavirus will be confirmed, this would help to solve two problems in Russia at once, at the same time decreasing alcohol addiction in the population.

Disulfiram fights SARS-CoV-2 in two ways. First, as previously demonstrated in vitro with SARS and MERS coronaviruses, it is a covalent inhibitor. In addition, it fights COVID-19 symptoms such as the significant decrease in reduced glutathione, which is an important antioxidant. This deficiency may lead to severe manifestations of the disease.

In addition to disulfiram, the Russian chemists were the first to predict the potential efficiency of neratinib, an irreversible tyrosine kinase inhibitor, against SARS-CoV-2. Just recently, in 2017, FDA approved neratinib as an adjuvant treatment of breast cancer.

Modeling has shown that both potential inhibitors of the main coronavirus protease (Mpro) are, presumably, covalent. For example, disulfiram can probably block the Mpro enzymatic activity by thioldisulfide exchange reaction, while neratinib binding suggests the possibility of covalent interaction similarly to covalent peptide inhibitors.

Its important to clarify that any modeling can only predict such interactions, but not prove their presence. The research cycle consists of at least three stages: modeling, synthesis of potentially active structures, and biological (pharmaceutical) testing of the necessary activity real, rather than calculated effectiveness of the drug. Modeling alone, just like any other theoretical research, means nothing without following experimental confirmations. Thats why now is time for extensive practical work on validating the results received as part of on-top docking.

The tests that were performed on July 27, 2020, at Reaction Biology Corp., a certified laboratory in the U.S., demonstrated that disulfiram really inhibits Mpro in 100 nm concentration, which confirmed the results of the modeling. Unfortunately, the second substance neratinib demonstrated activity on Mpro, but it was insufficient for clinical use. On September 1, 2020, clinicians will start drug trials in vitro and in experimental treatments of patients with SARS-Cov-2.

Chinese biochemists carried out a massive experimental search for active structures simultaneously and independently of the Russian researchers. They have also detected potential activity of disulfiram to the SARS-CoV-2 virus main protease Mpro. Unfortunately, they did it two weeks earlier than the Russian chemists, so the publication in Nature is theirs (the paper will be issued in August). This serves as additional evidence of the importance of having powerful computational resources for modelling and capabilities for biological experiments.

We need an opportunity to claim the results immediately in a high-level Russian chemistry journal. And there are only a few of them. Unfortunately, if we approve only publications in 1st and 2nd quartile journals, which are exceptionally international, such Russian journals will never appear. Igor Svitanko, Doctor of Sciences (Chemistry), Professor at the HSE Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry

Meanwhile, the main achievement is the demonstration that the on-top docking approach is working and returns quite realistic and controllable results. The teams plans for late 2020 and 2021 include molecular modeling of treatments for diseases that have demonstrated their harmfulness but have not yet spread over the world.

Its important to mention that any molecular modeling requires significant computational resources, and before cooperating with HSE University, the chemists had been able to use their method only on very limited terms. Today, they have access to HSE Universitys powerful supercomputer, which can help them search among existing drugs and perform targeted synthesis of new pharmaceutical products.

This is a brilliant example of fruitful cooperation between a university and a Russian Academy of Sciences institute. An obvious next step in such academic cooperation is organizing a Laboratory of Molecular Modelling at HSE University. This laboratory would not only create drugs, but it would model various chemical processes both by means of docking or other simple methods and by more universal and complicated quantum chemistry methods.

Meanwhile, the global chemistry community is facing the next challenge modeling the structure of an inhibitor for the protein of the G4 EA H1N1 virus a novel swine flu that was recently been detected in China. Researchers believe that this infection is much more dangerous and transfers more quickly from a human to human than COVID-19. To deal with it, researchers will need support, both in terms of resources and tools, and they will also need support organizing productive academic work and priority setting.

Reference: Computational identification of disulfiram and neratinib as putative SARS-CoV-2 main protease inhibitors by Victor S. Stroylova and Igor V.Svitanko, 4 August 2020, Mendeleev Communications.DOI: 10.1016/j.mencom.2020.07.004

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Medication Used for Alcoholism Treatment Is Potentially Effective Against COVID-19 - SciTechDaily

Pharmaceuticals and Healthcare in the Civil Code – Lexology

The world will be in order if good laws are established. Chinas first Civil Code was approved at the third session of the 13th National Peoples Congress and will come into force on January 1, 2021. As a fundamental body of law with a solid foundation, stable expectations and long-term benefits, its compilation is a significant milestone for the rule of law in China. The Civil Code consists of seven parts: general provisions, real property, contracts, personality rights, marriage and family, inheritance and tort liability and covers all aspects of individuals personal and property relationships. In this article, we aim to highlight the most significant parts of the Civil Code that directly relate to pharmaceuticals and healthcare by comparing those parts with legal provisions that were previously scattered through a variety of pharmaceuticals and healthcare legislation.

1. The Part on Personality Rights: Pharmaceutical and Healthcare Provisions

The independent compilation of personality rights is a pioneering initiative of the Civil Code. It embodies the concept of people-oriented and responds to the challenges of protecting personality rights in the information age. Personality rights[1] are primarily the rights of natural persons that are based on personal freedom and human dignity. However, personality rights are not unique to natural persons. Legal persons also have personality rights. According to the Civil Code, the main personality rights of natural persons and legal persons are as follows:

From this it is evident that the protection of natural persons personality rights, especially the protection of life, body, health, privacy and personal information, will be closely related to the field of pharmaceuticals and healthcare.

The provisions concerning clinical trials of drugs and medical devices in China are scattered throughout sector-based or departmental legislation. This legislation incudes, for example, the Good Clinical Practice for Medical Device Trials (effective as June 1, 2016), the Good Practice for Clinical Trials of Drugs (effective as July 1, 2020), and the Law on Promotion of Basic Medical Care and Health (effective as June 1, 2020). The revision of the Civil Code contains provisions dealing with clinical trials on human beings, which are based on the relevant sector-based legislation, and summarizes the basic principles concerning such trials. It also reflects the importance attached in China to the rights of all people to life, body and health, and helps to promote the norms for, and healthy development of, clinical trials in the new drugs and medical devices fields. To illustrate, the table below compares the relevant sector-based regulations with the applicable provisions of the Civil Code.

Before the Civil Code was promulgated, the Regulations on Human Organs Transplantation (effective as of May 1, 2007), and the Regulations on Acquisition and Distribution of Human Donated Organs (effective as of March 1, 2019) regulated human organs donations and transplantations, but did not cover human cells or human tissues.

On July 10, 2008, the PRC Ministry of Health (this Ministry was dissolved in March 2013) issued the WHO Guidelines for Human Cell, Tissue and Organ Transplantation (Draft) (the draft was revised by the 62nd World Health Assembly on March 26, 2009 and reviewed and approved by the 63rd World Health Assembly on May 21, 2010). These Guidelines are used by hospitals in China that are qualified to perform human organs transplantations for reference in clinical practice. However, domestic legislation in China has not officially incorporated the WHO Guidelines for Human Cell, Tissue and Organ Transplantation.

The Regulations on Administration of Human Genetic Resources (effective as of July 1, 2017) prohibit the trading of organs, tissues and cells containing human genome, genes or any other genetic materials. However, there are no provisions regarding the donation of such organs, tissues or cells.

Hence, the compilation of the Civil Code not only establishes the basic principles underpinning the altruistic donation of human cells, tissues, organs and corpses, but also expressly prohibits the trading of human cells, tissues, organs and corpses in any form. This is one of the highlights of the revisions. It is expected that, after the promulgation of the Civil Code, rules governing the donation of human cells and tissues other than human organs may also be implemented and refined through sector-based or departmental legislation. The table below compares the relevant provisions contained in sector-based legislation and the relevant articles of the Civil Code.

Article 1009 of the Civil Code provides that persons engaged in medical and scientific research activities related to human genes, human embryos, etc. shall abide by laws, administrative regulations and relevant provisions of the State, and shall not endanger human health, violate ethics and morals or undermine public interests.

The Civil Code specifically provides for the legality and compliance of medical and scientific research activities in the field of human genes and human embryos, and emphasizes that such activities shall not contravene ethics or damage public interests. These provisions in the Civil Code appear to be a legislative response to He Jiankuis case[2] on gene-edited babies in 2018. Applying gene editing technology to human embryos is not only a fundamental breach of ethics, but also a violation of laws and regulations. In addition to the Civil Code, the Technical Specifications for Human Assisted Reproduction effective as of October 1, 2003 also expressly state that genetic manipulation of human gametes, zygotes and embryos for the purpose of reproduction is prohibited.

Furthermore, the Regulations on Administration of Human Genetic Resources, which came into force just one year ago (July 1, 2019), also contain detailed provisions on the collection, preservation and use of genetic materials containing human genes and other genetic materials. In this way, Chinas codified Civil Code keeps pace with the times, incorporates the latest legislative developments, and reflects the public interest and welfare needs.

The protection of privacy and personal information in the Civil Code is provided for in Chapter Six (Right of Privacy and Personal Information Protection) of Part Four (Personality Rights). This is also an important part of the Civil Code.

Privacy refers to a natural persons peaceful private life and his/her private space, private activities and private information that he/she does not wish to be known to others. Personal Information refers to various types of information recorded electronically or otherwise that can identify a specific natural person either alone or in combination with other information, including the natural persons name, date of birth, identity document number, biometric information, residential address, phone number, e-mail address, health information, location information, etc.

As one type of personal information, health information such as personal medical records and diagnostic data is usually private and not wishing to be known to others. With respect to personal information of a private nature, according to Paragraph 3 of Article 1034 of the Civil Code, personal information of a private nature shall be governed by the provisions on the right of privacy, and in the absence of applicable provisions thereof, by the provisions on personal information protection.

Under the Provisions for the Administration of Medical Records of Medical Institutions (effective as of January 1, 2014) (the Provisions), China has established strict requirements for the preservation of medical records. Article 6 of the Provisions states that medical institutions and their medical staff shall strictly protect the privacy of patients, and are strictly prohibited from disclosing patients medical records for any purpose other than medical treatment, teaching or research.

In addition, Article 1226 of Chapter VI (Medical Damage Liability) of Part Seven (Tort Liability) of the Civil Code provides that medical institutions and their medical personnel shall keep confidential the privacy and personal data of their patients, and that they shall bear tort liability if divulging their patients privacy and personal data or medical records without the patients consent.

2. The Part on Contracts: Improve Electronic Contract Rules, and Support the Standardized Development of the Internet, and Pharmaceuticals and Healthcare

Electronic contracts play an increasingly important role in the development of the market economy in China. This is also the case in the pharmaceuticals and healthcare industry. Paragraph 3 of Article 5 of the Guiding Opinions on Improving the Centralized Drug Procurement for Public Hospitals (Guo Ban Fa [2015] No. 7) specifies that, where conditions permit, eligible places are encouraged to conduct electronic transactions and to adopt various methods, such as signing electronic contracts and using online payments through a centralized drug procurement platform to save transaction costs and improve the transparency of transactions. Furthermore, it is inevitable that electronic contracts will be more widely used in Internet diagnosis and treatment, remote consultation, online sales of drugs and medical devices and other related activities. The Civil Code reflects the needs of the market and of the times, and includes pioneering provisions concerning the signing and performing electronic contracts.

The Civil Code confirms in Chapter II (Conclusion of Contract) of Part III (Contract) that an electronic contract is a written contract (Article 469[3]). The rules governing the date[4] (Article 491) and place (Article 492[5]) of the conclusion of the electronic contract are set forth in the general provisions, as shown in the table below. These rules may be excluded by agreement of the parties.

Chapter IV (Performance of the Contract) in Part III (Contract) sets forth general provisions concerning the delivery time of the subject matter of an electronic contract (Article 512[6]), which depends on the subject matter and delivery method. Where the parties do not agree in the electronic contract on specific arrangements for delivery, the delivery time shall be determined in accordance with the rules in the table below. These rules may also be excluded by agreement of the parties.

Following the promulgation of the Measures for the Administration of Internet Drug Information Services (on November 17, 2017), the Measures for the Administration of Internet Diagnosis and Treatment (for Trial Implementation) (on July 17, 2018), the Specifications for the Administration of Remote Medical Services (for Trial Implementation) (on July 17, 2018), and the relevant provisions on building an integrated online and offline medical service mode in the Law on Promotion of Basic Medical and Health (on June 1, 2020), the concept of Internet plus Pharmaceuticals and Healthcare has become something of a trend.

According to the Opinions on Promoting the Development of Internet Plus Pharmaceuticals and Healthcare issued by the General Office of the State Council on April 25, 2018, the Internet Plus Pharmaceuticals and Healthcare service system includes Internet Plus Public Health Services, Internet Plus Family Doctor Contractual Services, Internet Plus Medicine Supply Guarantee Services and Internet Plus Medical Insurance Settlement Services. The implementation of detailed rules in the Civil Code for the signing and performance of electronic contracts is without doubt beneficial to the healthy development of Chinas Internet-based healthcare industry. Specifically, when conducting online drugs sales, Internet diagnosis and treatment, remote consultation or other electronic transactions, if the parties concerned have no clear agreement on the date and place of formation of the contract and the delivery time of the subject matter, the relevant provisions of the Civil Code may be directly applied. This will help avoid unnecessary disputes and will facilitate consistent and healthy development of Internet Plus Pharmaceutical and Healthcare.

3. The Part on Tort Liability: Changes to Liability for Medical Malpractice

Chapter VI (Medical Malpractice Liability) of Part VII (Tort Liability) of the Civil Code provides for liability for medical malpractice. This chapter consists of eleven articles and has been revised for consistency with the Tort Liability Law. Below, based on a comparison of the Civil Code and the Tort Liability Law (effective as of July 1, 2010), we highlight the three main amendments to Chapter VI.

As indicated in the Civil Code, the method required for medical personnel to notify a patient of information concerning diagnosis and treatment is elevated from written consent to express consent. Formally, this expands the method by which medical personnel perform the obligation of notification. That is, it is not limited to a written form. However, the requirement for notification by medical personnel is elevated from explain to explain in detail. In essence, this enhances the standard and requirement of explanation, which is helpful to put the notification obligation of the medical personnel into effect and not become a mere formality.

First, the Civil Code limits the application of the presumption of fault by medical institutions to diagnosis and treatment activities only and defines in greater detail the scope of tort liability.

Second, the Civil Code includes the loss of medical records as a circumstance resulting in the presumption of fault, and increases the responsibility for medical record management by medical institutions. It also revises the destruction of medical records to illegal destruction of medical records, reflecting obligations contained in the Provisions on the Administration of Medical Records of Medical Institutions. The Provisions on the Administration of Medical Records of Medical Institutions state that the minimum preservation time for medical records will depend on whether the records concern outpatient (emergency) treatment or hospitalization[7]. In any event, the preservation time for medical records is not indefinite. Consequently, the presumption of tort liability of medical institutions does not apply to lawful putting in order and destruction of medical records.

First, the Civil Code now includes the marketing authorization holder as a party bearing de facto joint and several liability for medical products, reflecting similar provisions in the Drug Administration Law (which came into effect on December 1, 2019). The Drug Administration Law added a new chapter containing a system to manage market authorization holders. It also provides in Article 6 of the General Provisions for the State to implement a drug marketing authorization holder system for drug administration, with the marketing authorization holder being responsible for the safety, effectiveness and quality controllability of the drug during the whole process of drug research, production, distribution and use according to law. As a result, the provisions of the Civil Code are consistent with industry legislation, paving the way for the convergence and streamlined application of different laws and regulations.

Second, the Civil Code changes the scope of medical products to which de facto joint and several liability can attach, from medical disinfectants to disinfection products, which is consistent with the Measures for the Administration of Disinfection (which took effect on December 26, 2017). Article 45 of the Measures for the Administration of Disinfection contains a specific definition of disinfection products which includes disinfectants, disinfection apparatus (including biological indicators, chemical indicators and sterilized goods packaging), sanitary supplies and disposable medical supplies. As a result, this codification of the Civil Code reflects changes in industry legislation.

Summary

The Civil Code is an encyclopedia for social life and a manifesto of civil rights, which has constructed a comprehensive system for civil rights protection. Not only is it important for the national economy and individuals livelihood, the Civil Code also introduces basic provisions on many subjects in the field of pharmaceuticals and healthcare, such as protecting the right of informed consent of patients, strengthening the protection of patients privacy and personal information, establishing basic rules for donation of human organs and human tissues and specifying the scope of application for medical malpractice liability. Law is the most important instrument for governing a country. A code that evolves with the times is beneficial not only to the protection of individuals well-being but also to their fundamental interests.

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Pharmaceuticals and Healthcare in the Civil Code - Lexology

Why some people may not need 8 hours of sleep, according to a new report – Fox News

Unbothered after a few hours of sleep? Studies suggest that not everyone may need seven or eight hours as generally recommended.

Adults aged between 18 and 60 should aim for seven or more hours of sleepper night, according to recommendations from the Centers for Disease Control and Prevention (CDC).

Not getting enough sleep is linked with many chronic diseases and conditionssuch as type 2 diabetes, heart disease, obesity, and depressionthat threaten our nations health,"the CDC says."Not getting enough sleep can lead to motor vehicle crashes and mistakes at work, which cause a lot of injury and disability each year.

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However, a new report out of Time magazine highlighted work byneurology professors at the University of California, San Francisco (UCSF) on sleep genetics and varying circadian rhythms, or the bodys complex clock system" from person to person.

Peoples internal clocks could be off by hours from one another, perhaps explaining why some are early to rise, while others prefer to stay up late.

The UCSF professors -- married couple Dr. Louis Ptacek and Ying-Hui Fu --are pioneers in sleep genetics. About 10years ago, Fu and her research teamfound a rare genetic mutationlinked to naturalshort sleep -- or those who equally benefit from just four to sixhours ofsleep compared to others who get eight hours of shut-eye, according to the report.

Not everyone may need seven to eight hours as generally recommended, studies suggest. (iStock)

Last year, the scientists found another mutatedgene, and according to Time, Ptacek and Fu are set to submit an upcoming paper on another gene, building evidence that faring well on short sleep is a genetic trait.

If we can get a better understanding of why their sleep is more efficient, we can then come back and help everybody sleep more efficiently, Fu told the magazine.

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One research participant, Seemay Chou, also an employee at UCSF, and her mother underwent interviews and gave blood samples; both are short sleepers.Fu found that short sleepers are usually more energetic, optimistic, have higher pain tolerance, and increased longevity.

While there is still much to explore about sleep, Steven Lockley, associate professor of medicine at Harvard Medical School, says a person's internal clock is key to personalized medicine. In other words, the timing of certain medicines or tests could lead to more accurate or potent results, according to the report.

The report also referenced a small study out of Sweden, which found that men who exercised at 8 a.m. had higher levels of blood sugar than men who worked out at 4 p.m., hinting that exercise may have heightened benefits at certain times during the day.

Hopefully in the next five to 10 years, youd go to the doctor, give a breath test or a pee sample, and the doctor would know your biological time, Lockley told Time. Then all your test results and treatments could be based on your real internal time, which is going to be very different between you and me based on our internal clocks.

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Why some people may not need 8 hours of sleep, according to a new report - Fox News