Sangamo taps Mogrify for off-the-shelf CAR-Treg project – FierceBiotech

Sangamo Therapeutics has struck a deal with Mogrify to gain access to a source of cells for use in its allogeneic CAR-Treg therapies. The agreement sees Sangamo pay an upfront fee to get Mogrify to apply its direct cell conversion technology to the generation of regulatory T cells.

Ready access to sources of cells has emerged as a key area of focus for developers of off-the-shelf cell therapies, leading to deals such as Allogenes alliance with Notch Therapeutics. That deal, like other moves by allogeneic cell therapy players, reflected a desire to replace the finite donated T cells used in early off-the-shelf prospects with renewable, more scalable sources of starting materials.

Sangamo has identified Mogrify as a provider of such materials. Mogrify put itself on the map early last year when Darrin Disley, the former leader of Horizon Discovery, joined the startup as CEO and invested in its seed round. Months later, Mogrify raised a $16 million series A round.

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This virtual event will bring together industry experts to discuss the increasing pace of pharmaceutical innovation, the need to maintain data quality and integrity as new technologies are implemented and understand regulatory challenges to ensure compliance.

Mogrify attracted the interest of Disley, Sangamo and an investor syndicate led by Ahren Innovation Capital on the strength of its technology for converting one human cell type into another human cell type. In the case of the Sangamo deal, Mogrify will use the platform to convert induced pluripotent stem cells and embryonic stem cells into regulatory T cells.

RELATED:Bristol Myers' Juno unit enlists Oxford BioMedica for CAR-T work

The agreement with Sangamo tasks Mogrify with handling the discovery and optimization of the cell conversion technology. Sangamo will have exclusive rights to use the technology to generate Tregs. By applying its ZFP gene engineering technology to the Tregs, Sangamo plans to develop allogeneic cell therapies for use in the treatment of inflammatory and autoimmune diseases.

Sangamo is paying an upfront fee of undisclosed size to work with Mogrify. As programs based on the Tregs advance, Mogrify is in line to receive development and regulatory milestones, plus payments linked to product sales.

SPECIAL REPORT:Top biotech money raisers of 2019

News of the deal comes months after Sangamo got authorization in the U.K. to run a phase 1/2 trial of an autologous CAR-Treg cell therapy, TX200, in kidney transplant patients. Partnering with Mogrify will support Sangamos efforts to get allogeneic cell therapies into the clinic, building on its work with Kite Pharma to apply its technology to off-the-shelf cancer treatments such as CD19 CAR-T prospect KITE-037.

Having formed the pact with Sangamo, Mogrify now has two commercial deals with U.S. biopharma companies. The deals will provide Mogrify with a source of money as it works on internal cell therapy candidates in disease areas including musculoskeletal, autoimmune and cancer.

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Sangamo taps Mogrify for off-the-shelf CAR-Treg project - FierceBiotech

Mogrify and Sangamo announce collaboration and exclusive license agreement for Mogrify’s iPSC- and ESC-derived regulatory T cells – SelectScience

Mogrify Ltd (Mogrify), a UK company aiming to transform the development of cell therapies by the systematic discovery of novel cell conversions, and Sangamo Therapeutics (Sangamo), a genomic medicine company, have announced that they have executed a collaboration and exclusive license agreement for Sangamo to develop allogeneic cell therapies from Mogrifys proprietary induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) and Sangamos zinc finger protein (ZFP) gene-engineered chimeric antigen receptor regulatory T cell (CAR-Treg) technology.

Mogrify is delighted to announce its second commercial deal with a US biopharma and the first in the exciting field of T cell immunotherapy, said Dr. Darrin M. Disley OBE, CEO, Mogrify. The combination of Mogrifys proprietary systematic cell conversion technology and Sangamos regulatory T cell platform and proprietary ZFP platform is a natural fit. Sangamo is at the forefront of the development of a world-class engineered ZFP genome editing platform and we are very happy to be partnering with such an innovative company.

This license agreement provides Sangamo with access to Mogrifys cell conversion technology, which will diversify our options as we develop off-the-shelf allogeneic CAR-Treg cell therapies, said Jason Fontenot, SVP, Head of Cell Therapy at Sangamo. We expect this collaboration to accelerate our development of scalable and accessible CAR-Treg cell therapies, so that we can potentially deliver treatments to patients with inflammatory and autoimmune diseases more rapidly.

Mogrifys technology enables the transformation of any human cell type into any other human cell type. This transformation is achieved using transcription factors or small molecules identified using proprietary big data technologies. iPSCs and ESCs provide an evergreen starting material for the generation of Tregs, and facilitate more complex engineering and greater manufacturing scalability, potentially enabling the resulting therapies to be more cost-effective and thus more accessible to larger patient populations.

Under the terms of the agreement, Mogrify will be responsible for the discovery and optimization of the cell conversion technology from iPSCs or ESCs to regulatory T cells, and Sangamo will be granted exclusive rights to use Mogrifys technology to create Tregs from iPSCs or ESCs. Sangamo expects to then use its ZFP gene-engineering technology and therapeutic development capabilities to transform these Tregs into novel off-the-shelf allogeneic CAR-Treg cell therapy candidates and hopes to take them through clinical development through to registration for the treatment of inflammatory and autoimmune diseases.

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Mogrify and Sangamo announce collaboration and exclusive license agreement for Mogrify's iPSC- and ESC-derived regulatory T cells - SelectScience

Israeli COVID-19 treatment with 100% survival rate tested on US patient – The Jerusalem Post

Israeli-based Pluristem has treated its first American patient suffering from COVID-19 complications under the countrys compassionate use program.The news comes days after a report by the company showed that six critically ill coronavirus patients in Israel who are considered high-risk for mortality were treated with Pluristems placenta-based cell-therapy product and survived, according to preliminary data provided by the Haifa-based company.In the US case, the patient was treated with the companys PLX cell therapy at Holy Name Medical Center in New Jersey, where Pluristem is already running a Phase III critical limb ischemia study. Like the patients treated in Israel, this patient was critically ill with respiratory failure due to acute respiratory distress syndrome and was intubated in an intensive care unit for three weeks.The companys president and CEO, Yaky Yanay, said that although Pluristem is focused on a planned multinational clinical trial for the treatment of complications associated with coronavirus, it does hope to expand treatment under compassionate use in other countries at the same time.

Specifically, the US treatment was administered under the US Food and Drug Administrations Single Patient Expanded Access Program, which is part of the US Coronavirus Treatment Acceleration Program - an emergency program aimed at getting treatments to corona patients as quickly as possible.

In Israel, the six patients were treated at three different Israeli medical centers for one week, also under a compassionate use program. They were suffering from acute respiratory failure and inflammatory complications associated with COVID-19. Four of the six patients also demonstrated failure of other organ systems, including cardiovascular and kidney failure.

Pluristems PLX cells are allogeneic mesenchymal-like cells that have immunomodulatory properties, meaning they induce the immune systems natural regulatory T cells and M2 macrophages, the company explained in a previous release. The result could be the reversal of dangerous overactivation of the immune system. This would likely reduce the fatal symptoms of pneumonia and pneumonitis (general inflammation of lung tissue).

Previous preclinical findings regarding PLX cells revealed significant therapeutic effects in animal studies of pulmonary hypertension, lung fibrosis, acute kidney injury and gastrointestinal injury.

We are pleased with this initial outcome of the compassionate use program and committed to harnessing PLX cells for the benefit of patients and healthcare systems, Yanay said.

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Israeli COVID-19 treatment with 100% survival rate tested on US patient - The Jerusalem Post

Sangamo ties up with a newcomer in the cell therapy field; LabCorp wins FDA authorization of latest Covid-19 test – Endpoints News

We have another fuzzy snapshot of clinical trial data on Gileads remdesivir in coronavirus patients, and at first glance this one looks bleak for the most advanced therapy now in the clinic for Covid-19.

The Financial Times and STAT both reported on an abstract of the Chinese study, this one using a control group that appeared temporarily on the WHO site after it was posted accidentally. Its still not been peer reviewed, but Salim Syed at Mizuho summarized the numbers:Of the 237 patients that were studied in the trial, 158 were on remdesivir, and 79 were on control, and remdesivir did not produce a difference in mortality at 28 days (13.9% for remdesivir vs 12.8% for control).Taken at face value, thats a nasty failure. The stock dropped 4% this afternoon. BUT you cant take it at face value, as Gilead pointed out in a followup statement.

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Sangamo ties up with a newcomer in the cell therapy field; LabCorp wins FDA authorization of latest Covid-19 test - Endpoints News

Stem Cell Therapy Market Overview by 2026: Verified Market Research – Cole of Duty

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Global Stem Cell Therapy Market Segmentation

This market was divided into types, applications and regions. The growth of each segment provides an accurate calculation and forecast of sales by type and application in terms of volume and value for the period between 2020 and 2026. This analysis can help you develop your business by targeting niche markets. Market share data are available at global and regional levels. The regions covered by the report are North America, Europe, the Asia-Pacific region, the Middle East, and Africa and Latin America. Research analysts understand the competitive forces and provide competitive analysis for each competitor separately.

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Global Stem Cell Therapy Market Regions and Countries Level Analysis

The regional analysis is a very complete part of this report. This segmentation highlights Stem Cell Therapy sales at regional and national levels. This data provides a detailed and accurate analysis of volume by country and an analysis of market size by region of the world market.

The report provides an in-depth assessment of growth and other aspects of the market in key countries such as the United States, Canada, Mexico, Germany, France, the United Kingdom, Russia and the United States Italy, China, Japan, South Korea, India, Australia, Brazil and Saudi Arabia. The chapter on the competitive landscape of the global market report contains important information on market participants such as business overview, total sales (financial data), market potential, global presence, Stem Cell Therapy sales and earnings, market share, prices, production locations and facilities, products offered and applied strategies. This study provides Stem Cell Therapy sales, revenue, and market share for each player covered in this report for a period between 2016 and 2020.

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Our report helps readers decipher the current and future constraints of the Stem Cell Therapy market and formulate optimal business strategies to maximize market growth.

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Study Coverage: It includes study objectives, years considered for the research study, growth rate and Stem Cell Therapy market size of type and application segments, key manufacturers covered, product scope, and highlights of segmental analysis.

Executive Summary: In this section, the report focuses on analysis of macroscopic indicators, market issues, drivers, and trends, competitive landscape, CAGR of the global Stem Cell Therapy market, and global production. Under the global production chapter, the authors of the report have included market pricing and trends, global capacity, global production, and global revenue forecasts.

Stem Cell Therapy Market Size by Manufacturer: Here, the report concentrates on revenue and production shares of manufacturers for all the years of the forecast period. It also focuses on price by manufacturer and expansion plans and mergers and acquisitions of companies.

Production by Region: It shows how the revenue and production in the global market are distributed among different regions. Each regional market is extensively studied here on the basis of import and export, key players, revenue, and production.

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Stem Cell Therapy Market Overview by 2026: Verified Market Research - Cole of Duty

World coronavirus Dispatch: Animal Stem Cell Therapy Expected to Witness a Fast-paced Growth Over the Forecast Period 2017 2025 – Latest Herald

Given the debilitating impact of COVID-19 (Coronavirus) on the Animal Stem Cell Therapy market, companies are vying opportunities to stay afloat in the market landscape. Gain access to our latest research analysis on COVID-19 associated with the Animal Stem Cell Therapy market and understand how market players are adopting new strategies to mitigate the impact of the pandemic.

The report provides both quantitative and qualitative information of global Animal Stem Cell Therapy market for period of 2018 to 2025. As per the analysis provided in the report, the global market of Animal Stem Cell Therapy is estimated to growth at a CAGR of _% during the forecast period 2018 to 2025 and is expected to rise to USD _ million/billion by the end of year 2025. In the year 2016, the global Animal Stem Cell Therapy market was valued at USD _ million/billion.

This research report based on Animal Stem Cell Therapy market and available with Market Study Report includes latest and upcoming industry trends in addition to the global spectrum of the Animal Stem Cell Therapy market that includes numerous regions. Likewise, the report also expands on intricate details pertaining to contributions by key players, demand and supply analysis as well as market share growth of the Animal Stem Cell Therapy industry.

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Animal Stem Cell Therapy Market Overview:

The Research projects that the Animal Stem Cell Therapy market size will grow from in 2018 to by 2024, at an estimated CAGR of XX%. The base year considered for the study is 2018, and the market size is projected from 2018 to 2024.

Leading manufacturers of Animal Stem Cell Therapy Market:

Key Participants

The key participants in the animal stem cell therapy market are Magellan Stem Cells, ANIMAL CELL THERAPIES, Abbott Animal Hospital, VETSTEM BIOPHARMA, Veterinary Hospital and Clinic Frisco, CO, etc. The companies are entering into the collaboration and partnership to keep up the pace of the innovations.

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World coronavirus Dispatch: Animal Stem Cell Therapy Expected to Witness a Fast-paced Growth Over the Forecast Period 2017 2025 - Latest Herald

FTC Sends 21 Letters Warning Marketers to Stop Making Unsupported Claims That Their Products and Therapies Can Effectively Treat Coronavirus – Sierra…

Supposed therapies range from stem cell infusions to acupuncture and ozone treatments

April 24, 2020 - The Federal Trade Commission announced it has sent 21 additional letters warning marketers throughout the United States to stop making unsubstantiated claims that their products and therapies can treat or prevent coronavirus (COVID-19). This is third set of warning letters the FTC has sent to sellers of such products as part of its ongoing efforts to protect consumers from COVID-19 related scams.

The FTCpreviously sent warning lettersto the sellers of supplements including colloidal silver, teas, essential oils, and other products pitched as scientifically proven coronavirus treatments. The letters announced today, however, address a wider range of products and supposed treatments, including some that may appear more medically sophisticated to consumers, such as acupuncture, intravenous (IV) therapies with high doses of Vitamin C, ozone therapy, and purported stem cell treatments. However, there is currently no scientific evidence that these products or services can treat or cure coronavirus.

The FTC sent the letters announced today to the companies and individuals listed below. The recipients are grouped based on the type of therapy, product, or service they pitched to supposedly prevent or treat coronavirus disease.

General Therapy Products, Vitamins, and Supplements:

IV Therapy and Related Treatments:

Ozone Therapy:

Stem Cell Therapy:

In the letters, the FTC states that one or more of the efficacy claims made by the marketers are unsubstantiated because they are not supported by scientific evidence, and therefore violate the FTC Act. The letters advise the recipients to immediately cease making all claims that their products can treat or cure coronavirus and to notify the FTC within 48 hours about the specific actions they have taken to address the agencys concerns.

The letters note that if the false claims do not cease, the Commission may seek a federal court injunction and an order requiring money to be refunded to consumers.

The letters announced today are the latest round of warnings the FTC has sent to sellers of products pitched as able treat or prevent coronavirus. The Commission also has sentletters to several Voice over Internet Protocol (VoIP) service providers, warning them that it is illegal to aid or facilitate the transmission of pre-recorded telemarketing robocalls pitching supposed coronavirus-related products or services.

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FTC Sends 21 Letters Warning Marketers to Stop Making Unsupported Claims That Their Products and Therapies Can Effectively Treat Coronavirus - Sierra...

Dr. Gaines of LifeGaines Informs Patients about NAD’s Role in Keeping a Healthy Immune System. Dr. Gaines is also Conducting Telehealth Consultations…

LifeGaines Medical and Aesthetics in Boca Raton serves South Floridians with age management therapies. Dr. Gaines discusses NAD's role in keeping a vibrant immune system. He is also conducting Physician Telehealth Consultations for those who want to achieve health and beauty goals during this time

Boca Raton, Florida--(Newsfile Corp. - April 24, 2020) - Dr. Gaines recently sent a message to his patients about keeping a healthy immune system, which also needs to be shared with the greater South Florida community.

LifeGaines Medical & Aesthetics is located at 3785 N. Federal Hwy, Suite150, Boca Raton, FL 33431. Go to http://www.lifegaines.com to learn more.

To view an enhanced version of this graphic, please visit:https://media.zenfs.com/en-us/newsfile_64/8b904d33bd4eec7c2103e25376df31d9

NAD+'s Role in Keeping A Healthy Immune System

As people continue to cope with the pandemic, most people have thought about their immune system but have not considered the role NAD+ plays and how it can affect their response to a deadly virus.

NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme found in every cell of one's body and helps the immune system function at its best by repairing and remodeling cells.

A viral infection causes free radicals to form which causes DNA damage. In order to repair DNA, the body needs high levels of NAD+. When people are young, high levels of NAD+ are present in their cells, but as people age, those levels deplete and can make people more susceptible to infection.

NAD+ IV therapy is a good solution to replenish one's NAD+ levels in the fight against viruses but it has many additional benefits. It is usually recommended in a series of 3 weekly treatments by LifeGaines, but will be customized based on each patient's specific needs. The NAD+ IV therapy is a slow drip process, so it takes time to enter into your system, generally 3-4 hours per treatment. NAD+ IV therapy can;

For more information on NAD+ IV Therapy, call the office of LifeGaines at (561) 931-2430.

Also, LifeGaines advises its patients to maintain their goals of health and beauty by participating in a telehealth consultation with Dr. Gaines.

Issues that can be addressed in a telehealth consultation:

Complimentary aesthetics consultations can determine someone's needs for:

Any new patient virtual appointment will receive 10% off a future in-office service! Inquire about Telehealth consultations. Call (561) 931-2430.

Dr. Richard Gaines is the Chief Medical Officer of LifeGaines Medical and Aesthetics, an age management medical practice located in Boca Raton, FL. His new practice offers a complete regenerative medicine program for men and women, including hormone optimization, sexual health, as well as facial rejuvenation.

LifeGaines Medical & Aesthetics is located at 3785 N. Federal Hwy, Suite 150 Boca Raton, FL 33431. Go to http://www.lifegaines.com to learn more. For any media inquiries, contact Kellie Keitel at kellie@lifegaines.com.

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inquire-about-telehealth.png Inquire about Telehealth consultations. Call (561) 931-2430. LifeGaines Medical & Aesthetics is located at 3785 N. Federal Hwy, Suite 150 Boca Raton, FL 33431. Go to http://www.lifegaines.com to learn more.

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/54847

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Dr. Gaines of LifeGaines Informs Patients about NAD's Role in Keeping a Healthy Immune System. Dr. Gaines is also Conducting Telehealth Consultations...

Scientists just discovered a new surprising benefit of coffee – Ladders

Its becoming increasingly difficult to consider caffeine a vice with everything we now know about the multifaceted benefits linked to habitual coffee consumption.

From longevity to a healthy gut microbe to curbing obesity and preventing dementia, java is an undeniable contender in new-age diet science. This isnt to suggest that all of its rewards are tangled up in dense medical literature about diseases and mortality rates.

In fact, a new study conducted by researchers at Aarhus University concludes that a single couple of coffee dramatically enhances our sensitivity to sweetness and diminishes our sensitivity to bitterness.

Chemosensory sensitivity has great variation between individuals. This variation complicates the chemosensory diagnostics, as well as the creation of a meal with universally high hedonic value. To ensure accurate characterization of chemosensory function, a common rule of thumb is to avoid food/beverages one hour before chemosensory testing. However, the scientific foundation of this time of fast remains unclear, the authors of the new paper write. Our findings provide the first evidence of how coffee impacts short-term taste sensitivity and consequently the way we sense and perceive food following coffee intake-an an important insight in the context of gastronomy, as well as in chemosensory testing procedures.

The researchers began with a study pool consisting of 156 test subjects.

Each had their sense of smell and taste analyzed before and after being administered a single cup of caffeinated coffee. Although there were no observable alterations to their sense of smell after coffee consumption, the subjects sense of taste was profoundly affected.

Via self-reports, the respondents reacted more readily to sweet substances while being less attuned to bitter ones. Caffeine didnt seem to be influencing these outcomes, considering they were successfully replicated after the researchers supplied participants with decaffeinated coffee.

Its probably some of the bitter substances in the coffee that create this effect. This may explain that if you enjoy a piece of dark chocolate with your coffee, its taste is much milder, because the bitterness is downplayed and the sweetness is enhanced, says study author, Alexander Wieck Fjldstad. We already know that our senses have an effect on each other, but its a surprise that our registration of sweetness and bitterness is so easily influenced.

Uncovering the intricate dynamics that different dietary agents share with another opens avenues for other important fields of research.

There are a host of foods confirmed to be conducive to healthy aging and development that might be consumed more frequently if paired with tempering elements.

Coffee compliments powerful sources of protein like nuts and almonds perfectly, just as a glass of grapefruit juice extends the half-life of caffeine.

More research in this area could have significance for how we regulate the way in which we use sugar and sweeteners as food additives. Improved knowledge can potentially be utilized to reduce sugar and calories in our food, which would be beneficial for a number of groups, including those who are overweight and diabetes patients, Wieck Fjldstad explains.

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Scientists just discovered a new surprising benefit of coffee - Ladders

Liberty Health Sciences Announces Expansion of its Cannabis Brand Portfolio – Yahoo Finance

Liberty's portfolio of premium products include Clarity Brands, Papa's Herb, Mary's Medicinal, G Pen, PAX, Lemon and Grass, Liberty Health Sciences, Zentient and Pretty Pistil

TORONTO, April 24, 2020 /PRNewswire/ - Liberty Health Sciences Inc. (CSE: LHS) (OTCQX: LHSIF) http://www.libertyhealthsciences.com("Liberty" or the "Company"), a provider of high quality cannabis,announced today the expansion to its award-winning brand portfolio of premium products that are available at all of its locations in Florida. Today Liberty launched its Liberty Health Sciences Shake brand to join its expanded and current portfolio that includes innovative cannabis products and formats, including premium flower, CBD, topicals, tinctures, extract and vape products.

Liberty Health Sciences Inc. (CNW Group/Liberty Health Sciences Inc.)

Liberty recently introduced Clarity Brands http://www.claritybrands.lifethat includes oil derived products on cartridges and G Pen pods and is available in all of its stores.

The Company has also recently introduced the all-new Papa's Herb classic 510 Cartridge pen to its Papa's Herb line up that has proven to be a popular new item in all of the dispensaries. In addition, Liberty has extended its popular offering of G Pen devices to include Roam, Elite, Connect, Gio, Pro, and Nova.

"We are always looking for ways to enhance our product offerings and find ways to better serve our patient's needs," said Victor Mancebo, Chief Executive Officer of Liberty. "Our passion and determination is to provide accessibility of best in class products at valued prices, especially during these challenging times. We are excited to grow our offering and provide the right cannabis derived medical options at a time when people need affordable ways to maintain their wellness and continue to practice social distancing."

Products under the Liberty umbrella include:

Clarity Brands: Clarity Brands promotes the clarification of body and soul through the use of cannabis products that are lab tested and organically and locally farm grown.

Zentient: Zentient represents a line of premium CBD and THC balanced products including topicals, vapes, and oral solutions made from a proprietary formula of ultra-high-quality cannabinoids.

Pretty Pistil: Pretty Pistil is a powerful (feminine house brand) that brings a beautifully balanced approach to high quality cannabis experiences for those with sophisticated tastes and a rebellious spirit.

Papa's Herb:Papa's Herb specializes in providing value products to the market. The brand highly prioritizes and is hyper-focused on their customers first. They offer quality Flower products at an always accessible price-point for all to enjoy.

Mary's Medicinal:Best known as the developer and exclusive distributor of the award-winning Transdermal Cannabis Patch, Mary's is transforming how people view and utilize cannabis; developing products that maximize the benefits of cannabinoids, terpenes, and other plant nutrients.

G Pen: Grenco Science, the maker of the G Pen Gio, Pro, Connect, Elite and Nova, is a leader in engineering advanced cannabis vaporizers, known for its aesthetics, portability, functionality, and user experience.

PAX: PAX is a leader in the design and development of premium cannabis vaporization technologies and devices.

Lemon and Grass: Lemon and Grass combines nature, science, and tech to formulate, and deliver, the highest standard of product. We strive for consistency to ensure that each and every time you use Lemon and Grass products, the results are reliable.

Story continues

Visit Liberty's social media channels for further details:

Facebook:https://www.facebook.com/LibertyHealthSciences Instagram: https://www.instagram.com/libertyhealthsciences/ Twitter: https://twitter.com/LibertyHSInc #LiveFree

Patients may place an order online at: http://www.libertyhealthsciences.comfor in-store pick-up or free delivery.

About Liberty Health Sciences Inc.Liberty is the cannabis provider committed to providing a trusted, high quality cannabis experience based on our genuine care for all cannabis users and a focus on operational excellence from seed to sale. Liberty's measured approach to expansion opportunities is focused on maximizing returns to shareholders, while keeping consumers' well-being at the forefront of what we do. For more information, please visit: http://www.libertyhealthsciences.com.

CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS: This press release contains certain forward-looking statements within the meaning of applicable securities laws. Any statements that are contained in this news release that are not statements of historical fact may be deemed to be forward-looking statements. Forward-looking statements are often identified by terms such as "may", "should", "anticipate", "expect", "believe", "plan", "intend" or the negative of these terms and similar expressions. Forward-looking statements in this news release include, but are not limited to, expectations related to the Company's production capabilities, expectations concerning the receipt of all necessary approvals from the Florida Department of Health, expectations concerning the opening of new dispensaries and the expansion of its greenhouse space, and the Company's future expansion and growth strategies. Forward-looking statements necessarily involve known and unknown risks, including, without limitation, risks associated with general economic conditions; adverse industry events; marketing costs; loss of markets; future legislative and regulatory developments involving medical marijuana; inability to access sufficient capital from internal and external sources, and/or inability to access sufficient capital on favorable terms; the medical marijuana industry in the United States generally, income tax and regulatory matters; the ability of Liberty to implement its business strategies; competition; crop failure; currency and interest rate fluctuations and other risks. Readers are cautioned that the foregoing list is not exhaustive. Readers are further cautioned not to place undue reliance on forward-looking statements as there can be no assurance that the plans, intentions or expectations upon which they are placed will occur. Such information, although considered reasonable by management at the time of preparation, may prove to be incorrect and actual results may differ materially from those anticipated. Forward-looking statements contained in this news release are expressly qualified by this cautionary statement.

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Liberty Health Sciences Announces Expansion of its Cannabis Brand Portfolio - Yahoo Finance

Deja Gaston and Alex Murphy: Coronavirus protesters demand ‘liberty’ at the expense of the rest of us – Salt Lake Tribune

It was troubling to see the Utah Business Revival protest that took place at Washington Square in Salt Lake City last weekend.

It was troubling because this protest seems to have emboldened reactionary, anti-science fringe movements even as health experts continue to show the need for social distancing measures.

It was also troubling because four months ago at the same location, 100 police officers in riot gear dismantled a demonstration featuring a diverse coalition of working-class activists and homeless people. Those demonstrators made demands for better conditions for the homeless. The protest was nonviolent and featured free first aid, daily meals and winter supplies for those in need. Yet the Salt Lake City Police Department suppressed it as if it were an armed occupation.

Saturdays event featured a speaker who actually once led an armed occupation Ammon Bundy. Also of note is that the event, which brought over 1,000 people into one of the most infected zip codes in the state, was organized by a former Salt Lake City Police Department officer who was placed on leave for anti-LGBTQ bigotry. Despite these details, as well as a sea of Dont Tread on Me flags wielded by a nearly all-white audience, the event was tread on by no one. The police had almost no presence at the event at all, much less a suppressive one.

Highlighting the disparity in police response is not to call for more aggressive policing. Instead, it points out that, as much as they say otherwise, the police do take sides. They are a plainly political organization that upholds racism and the dominance of property owners.

What was particularly troubling about Saturdays event were the demands made under the guise of individual liberty. Business owners demanded that the county allow them to force their employees back to work before it is safe. Landlords demanded that the state allow them to aggressively collect rent again. Middle-class suburbanites demanded that service workers be able to start serving them again. These are the demands of a plummeting middle class that is trying to keep up with an impossibly rich, exploitative class at the expense of everyones health.

Instead, working people must make demands that acknowledge the needs of those who are most at risk. Essential workers, who are largely low-income and nonwhite, dont need more businesses to open back up. What we need to fight the virus is sick pay, 100% unemployment insurance, a moratorium on rents and mortgages, a release of huge numbers of incarcerated people to prevent virus hot spots, secure housing for all and free COVID-19 testing and health care.

Rather than demand liberty for the individual, it is time to fight for liberation of the many including communities of color, unsheltered people, older Americans, incarcerated people, students and all poor and working-class people.

Deja Gaston and Alex Murphy are Utah community organizers and members of the Party for Socialism and Liberation.

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Deja Gaston and Alex Murphy: Coronavirus protesters demand 'liberty' at the expense of the rest of us - Salt Lake Tribune

$2.11 $2.37: is It Good Range to Buy Liberty TripAdvisor Holdings, Inc. (LTRPA)? – The News Heater

Liberty TripAdvisor Holdings, Inc. (NASDAQ:LTRPA) went up by 4.19% from its latest closing price when compared to the 1-year high value of $15.85 and move down -607.59%, while LTRPA stocks collected -6.67% of loss with the last five trading sessions. Barron's reported on 02/20/19 that 2 Deal Opportunities as John Malone Untangles His Empire

Liberty TripAdvisor Holdings, Inc. (NASDAQ: LTRPA) The 36 Months beta value for LTRPA stocks is at 2.31, while of the analysts out of 0 who provided ratings for Liberty TripAdvisor Holdings, Inc. stocks as a buy while as overweight, rated it as hold and as sell. The average price we get from analysts is $8.00 which is $5.76 above current price. LTRPA currently has a short float of 2.35% and public float of 72.14M with average trading volume of 2.08M shares.

LTRPA stocks went down by -6.67% for the week, with the monthly jump of 14.29% and a quarterly performance of -68.58%, while its annual performance rate touched -84.69%. The simple moving average for the period of the last 20 days is 11.06% for LTRPA stocks with the simple moving average of -69.34% for the last 200 days.

Many brokerage firms have already submitted their reports for LTRPA stocks, with Guggenheim repeating the rating for LTRPA shares by setting it to Neutral. The predicted price for LTRPA socks in the upcoming period according to Guggenheim is $160 based on the research report published on June 13, 2019.

Evercore ISI, on the other hand, stated in their research note that they expect to see LTRPA stock at the price of $12.50. The rating they have provided for LTRPA stocks is In-line according to the report published on October 16, 2018.

Guggenheim gave Sell rating to LTRPA stocks, setting the target price at $12.50 in the report published on May 25, 2018.

After a stumble in the market that brought LTRPA to its low price for the period of the last 52 weeks, Liberty TripAdvisor Holdings, Inc. was unable to take a rebound, for now settling with -85.87% of loss for the given period.

The stock volatility was left at 20.77%, however, within the period of a single month, the volatility rate increased by 13.11%, while the shares sank at the distance of -0.44% for the moving average in the last 20 days. In oppose to the moving average for the last 50 days, trading by -66.32% lower at the present time.

In the course of the last 5 trading sessions, LTRPA went down by -6.67%, which changed the moving average for the period of 200 days to the total of -81.70% of losses for the stock in comparison to the 20-day moving average settled at $2.02. In addition, Liberty TripAdvisor Holdings, Inc. saw -69.52% in overturn over the period of a single year with a tendency to cut further losses.

Reports are indicating that there were more than several insider trading activities at Liberty TripAdvisor Holdings, Inc. (LTRPA), starting from MAFFEI GREGORY B, who bought 15,408 shares at the price of $10.38 back on Sep 13. After this action, Rushing now owns 2,785,581 shares of Liberty TripAdvisor Holdings, Inc., valued at $160,004 with the latest closing price.

The current profitability levels are settled at +8.27 for the present operating margin and +64.29 for gross margin. The net margin for Liberty TripAdvisor Holdings, Inc. stands at -1.41. Total capital return value is set at 3.21, while invested capital returns managed to touch -3.10. Equity return holds the value -6.80%, with -0.40% for asset returns.

Based on Liberty TripAdvisor Holdings, Inc. (LTRPA), the companys capital structure generated 162.50 points for debt to equity in total, while total debt to capital is set at the value of 61.90. Total debt to assets is settled at the value of 10.86 with long-term debt to equity ratio rests at 5.86 and long-term debt to capital is 154.69.

The value for Enterprise to Sales is 0.23 with debt to enterprise value settled at 0.14. The receivables turnover for Liberty TripAdvisor Holdings, Inc. is 7.90 with the total asset turnover at the value of 0.31. The liquidity ratio also appears to be rather interesting for investors as it stands at 1.27.

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$2.11 $2.37: is It Good Range to Buy Liberty TripAdvisor Holdings, Inc. (LTRPA)? - The News Heater

Lansdales Liberty Bell Trail Named Region Project Of The Year – Montgomeryville, PA Patch

LANSDALE, PA A trail in Lansdale has received recognition for excellence by the American Society of Highway Engineers, which cited the project's complexity as well as its significance to the area economy and long term master plan.

The Liberty Bell Trail, the latest phase of which was completed in Oct. 2019, has been named the Delaware Valley 2019 Project of the Year in the under $10 million category, Pennoni, an engineering firm which assisted on the project, announced.

"This project met and exceeded the Borough's goals and objectives. From start to finish, this project was a true collaboration between all parties and I applaud the entire project team for their efforts in not only making this project a success but also for their continued commitment to the future of Lansdale," John Ernst, Lansdale's borough manager, said in a statement.

The 10-foot-wide multi-use trail which runs through the heart of downtown Lansdale was no easy task to perfect. Lansdale and Montgomery County worked closed with SEPTA, Pennoni, PennDOT, the Delaware Valley Regional Planning Commission, and the Pennsylvania Northeastern Railroad on various aspects of the project.

Some of the features noted by the award's organizers include the prefabricated bridge which crosses a large drainage channel next to the SEPTA tracks, as well as carefully planned at-grade rail crossings.

The trail not only increases walkability and recreation access while serving as a boon to the borough's economy, but it's also a "significant piece" of a larger puzzle in regional trails.

The project has been planned and been in varying stages of development for years. Regional developers foresee that the trail could ultimately run the length of the Liberty Bell Trolley Line between Norristown and Quakertown, which would link Lansdale to both the Schuylkill River Trail and Upper Bucks Rail Trail. Feasibility studies for further extensions have been completed or are underway.

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Lansdales Liberty Bell Trail Named Region Project Of The Year - Montgomeryville, PA Patch

The Debate Between Liberty-Minded and Common-Good Conservatives Is Nothing New – National Review

National Review founder William F. Buckley Jr.Its been raging since Milton Friedman and Bill Buckley duked it out on Firing Line five decades ago.

Between Sohrab Ahmaris denunciations of David Frenchism, Adrian Vermeules murkily authoritarian common-good constitutionalism, and Patrick Deneens book-long broadside against the liberal tradition, much ink has been spilled about the emergent ideological fissures within American conservatism. But such debates are hardly new. In fact, theyve been going on for at least five decades.

All the way back in 1968, William F. Buckley Jr. published a little book called Gratitude. Subtitled Reflections On What We Owe To Our Country, the book was Buckleys attempt to propose a Switzerland-style national-service program for Americas youth, born out of his concern that the younger generation lacked responsibility and patriotism. No doubt fully aware of the controversy that his proposal would ignite among many of his fellow travelers on the political right, Buckley wrote:

The conviction of some conservatives that the state cant have a genuine, non-predatory interest in the cultivation of virtue strikes me as an anarchical accretion in modern conservative thought, something that grew from too humorless a reading of such spirited individualists as Albert Jay Nock and H.L. Mencken. . . . National service, if transformed merely into a state bureaucracy with huge powers of intimidation, is not only to be avoided, but to be fought. But we can open our minds to something other than a statist program, or one that lodges in the state the kind of power conservatives have been taught, at great historical expense, to husband for social uses.

So conscious was Buckley of the ire that his argument would provoke from the libertarian faction of the conservative coalition, he wrote an entire chapter entitled Anticipating the Libertarian Argument. Despite his support for free markets, he begrudgingly acknowledged the limitations of economic liberty. The deep wellsprings of patriotism are fed by other forces, and these do not leave fingerprints in the market, he wrote. They must be investigated by the use of entirely different instruments.

This is similar to a view that many of the more market-skeptical Burkean traditionalists have expressed in contemporary intra-conservative debates: the idea that the state has a vested interest in protecting and even proactively nurturing our civic institutions, placing some aspects of our cultural inheritance beyond the reach of the creative destruction that is inherent to any dynamic liberal society. Its a view that stems from a particular concern for what Buckley called connections between the individual and the community beyond those that relate either to the state or to the marketplace.

As Buckley expected, many prominent libertarians remained unconvinced by his ambitious case for a national-service program. Milton Friedman, the great padrino of classical liberalism and an old friend of Buckleys, was particularly upset by the proposal. In a now-famous Firing Line debate between the two, Friedman thundered: I am absolutely astounded that you, of all people, use the English language the way that you use it. Theres nothing voluntary about your program. . . . My God, whats happened to you?

Though it only lasted for about 25 minutes, the BuckleyFriedman debate crystallized the tug of war between common-good and liberty-minded conservatives that continues to this day. Friedman was the strident individualist, deeply suspicious of central planning and instinctually indignant at the prospect of expanding coercive state power. He denounced Buckleys organismic, collectivist philosophy, and, striking a characteristically Lockean tone, argued that our society is a collection of individuals who join together to achieve their common purposes, and the state is simply a mechanism through which they achieve their common purposes. Buckley, by contrast, argued that a decline in the collective virtue and patriotic duty of a people was a serious problem that could not be solved by private action alone. He shot back at Friedman that society is not a meaningless term, but rather a vehicle which will continue to protect your sons and mine, and that we have therefore an interest in the shape of.

This should all sound familiar to students of the contemporary rights internecine wars. Buckleys proposal of a national-service program that would act as a government-run promoter of good character was anathema to Friedman, who argued that the whole system of private enterprise itself functions as voluntary national service, using the terms correctly. A similar debate is occurring in our current moment: Some contemporary conservative thinkers have argued that, in our increasingly atomized and individualistic culture, the state must be more aggressive in promoting virtue, order, and the common good. Others, echoing Friedman, counter that liberty is the common good, at least insofar as the role of government is concerned.

For conservatives in both 1968 and today, the fundamental question remains the same: In a free society, how far should the state go in exercising its coercive powers to ensure positive outcomes for society? I object to it strenuously, Friedman said of such state action. I think its one of the typical cases of some people who think they know whats good for other people. Buckley, meanwhile, argued that some state action is justified by the necessity for virtuous citizenry.

It is worth noting, of course, that the two men agreed on the vast majority of political issues. Both understood themselves as advocating for freedom, republican democracy, a flourishing civil society, and a virtuous, self-governing people. The fiery nature of their debate was largely borne out of the fact that they understood themselves as being on the same side, and were thus upset at what they saw as the others betrayal of a shared vision.

Now more than ever, conservatives must take care to keep sight of what we share, however many contentious feuds may erupt over what we dont. Buckley and Friedman remain a great model of how to maintain a persistently deep friendship despite vehement disagreements. In the closing seconds of their storied 1968 debate, the two intellectual giants even flashed sheepish grins at each other. When the fight was over, there was a palpable exhalation throughout the television studio though they had been energetic rivals mere minutes before, the two men were companions once again. The lights began to dim, and the Firing Line music signaled the end of another episode.

Okay, Buckley smiled at Friedman. Ill see you in Alta, Milton.

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The Debate Between Liberty-Minded and Common-Good Conservatives Is Nothing New - National Review

Connecting Liberty Lake ready to help: Citys volunteers wait for calls from those in need – The Spokesman-Review

When schools closed and the shut down order began, the city of Liberty Lake swung into action. It activated a new Facebook group called Connecting Liberty Lake and recruited volunteers to sign up to help their neighbors with things like grocery deliveries.

Our goal is to connect people who need help with people who need assistance, said city administrator Katy Allen. We have a lot of volunteers signing up on Facebook.

Its a tried-and-true method for the city. A similar group called the Snow Angels matches volunteers with residents who need help shoveling the snow off sidewalks and driveways. Another group rakes leaves in the fall and still another does spring yard work. Weve used that same platform, Allen said.

It seems like every season we have something, said Operations and Maintenance Director Jennifer Camp.

When the city was under a boil-water order earlier this week it was able to martial volunteers who had signed up to shovel snow and rake leaves to bring bottled water to those who couldnt pick it up. It was very successful during the boil-water advisory, she said.

The Connecting Liberty Lake group has been popular since it began a month ago. There are 100 people signed up, Camp said.

But for some reason, no one has contacted the city to ask for help. Camp said theyre not sure if its because people dont know about it or if people are getting help in other ways.

Im not sure what it is, she said. This is different than our other efforts.

Camp said she has seen people seeking and receiving help on other community Facebook pages, including a mother who couldnt leave the house and needed diapers. Someone in the community volunteered to go to the store and get her some.

What Ive seen on the community pages is a lot of people helping each other out, she said. People are looking out for each other.

People can ask for whatever help they need, and the city will match them with a volunteer, Camp said. It could be anything from getting groceries to yard work.

Its really between the citizen asking for what they need and what a volunteer is willing to do, she said. The tasks could be endless, really. We just facilitate the coordination between the volunteer and the citizen in need.

Those who are in need of help can contact the city by calling (509) 755-6727 or sending an email to onlineinquiry@libertylakewa.gov. The city will then reach out to a volunteer who can help.

Meanwhile, the people who signed up to volunteer will go on the citys list of people willing to help in a time of need.

You can never have too many, Camp said. Once we create a database of volunteers, we can tap them for other things.

Thats something the city has already done. The snow angel and leaf-raking volunteers not only helped during the boil-water advisory, but the city also used the list to recruit volunteers to help set up the Winter Glow Christmas lighting event. They had so many people respond that they had to tell people to stop coming.

Allen said its clear people in Liberty Lake want to help each other.

If we had a natural disaster, I bet we could get 100 volunteers without trying, she said.

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Connecting Liberty Lake ready to help: Citys volunteers wait for calls from those in need - The Spokesman-Review

Rallying for the ‘freedom and liberty to work’ – Martha’s Vineyard Times

A group of protestors gathered at Five Corners on a cold and windy afternoon Wednesday for the freedom and liberty to work rally holding American flags and signs saying I want to buy local and Thank you hospital.

The number of protestors hovered around 10 as people came and stood peacefully in support of the rally to reopen businesses.

Kenny MacDonald, who helped organize the rally with Jamie and Robbie Douglas before they pulled out of the event and decided not to attend, ended up joining the protest, holding a sign that said, All jobs are essential. The Douglas brothers are part of the family that owns the Black Dog restaurant, cafe, and retail shops, which faced a backlash from the event.

The rally comes on the heels of similar events across the country in Michigan, Ohio, and a smaller event at the Bourne Rotary Sunday, urging the government to end stay-at-home orders and business closures.

Chris DeMello, a landscaper, said it was important for people to be safe but equally as important for them to keep working.

We have to try and find that sweet spot of keeping people safe, DeMello said. The economy cant stay down forever.

Jason Cray, an Oak Bluffs carpenter who was wearing a Trump hat, held a large American flag and a sign saying liberty, freedom, work, socialism sucks!

Cray, who is also an Iraq war veteran, said he didnt want anyone to be sick, but the economy could be hurt.

Weve got to fight for peoples right to feed their families, he said. You shut down an economy its economic suicide.

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Rallying for the 'freedom and liberty to work' - Martha's Vineyard Times

Is One Liberty Properties, Inc.’s (NYSE:OLP) ROE Of 6.4% Impressive? – Yahoo Finance

One of the best investments we can make is in our own knowledge and skill set. With that in mind, this article will work through how we can use Return On Equity (ROE) to better understand a business. By way of learning-by-doing, we'll look at ROE to gain a better understanding of One Liberty Properties, Inc. (NYSE:OLP).

Return on equity or ROE is an important factor to be considered by a shareholder because it tells them how effectively their capital is being reinvested. In other words, it is a profitability ratio which measures the rate of return on the capital provided by the company's shareholders.

View our latest analysis for One Liberty Properties

The formula for return on equity is:

Return on Equity = Net Profit (from continuing operations) Shareholders' Equity

So, based on the above formula, the ROE for One Liberty Properties is:

6.4% = US$19m US$292m (Based on the trailing twelve months to December 2019).

The 'return' refers to a company's earnings over the last year. That means that for every $1 worth of shareholders' equity, the company generated $0.06 in profit.

Arguably the easiest way to assess company's ROE is to compare it with the average in its industry. However, this method is only useful as a rough check, because companies do differ quite a bit within the same industry classification. The image below shows that One Liberty Properties has an ROE that is roughly in line with the REITs industry average (5.8%).

NYSE:OLP Past Revenue and Net Income April 23rd 2020

So while the ROE is not exceptional, at least its acceptable. Although the ROE is similar to the industry, we should still perform further checks to see if the company's ROE is being boosted by high debt levels. If true, then it is more an indication of risk than the potential. To know the 5 risks we have identified for One Liberty Properties visit our risks dashboard for free.

Most companies need money -- from somewhere -- to grow their profits. That cash can come from issuing shares, retained earnings, or debt. In the case of the first and second options, the ROE will reflect this use of cash, for growth. In the latter case, the debt used for growth will improve returns, but won't affect the total equity. Thus the use of debt can improve ROE, albeit along with extra risk in the case of stormy weather, metaphorically speaking.

One Liberty Properties clearly uses a high amount of debt to boost returns, as it has a debt to equity ratio of 1.54. Its ROE is quite low, even with the use of significant debt; that's not a good result, in our opinion. Debt increases risk and reduces options for the company in the future, so you generally want to see some good returns from using it.

Return on equity is a useful indicator of the ability of a business to generate profits and return them to shareholders. Companies that can achieve high returns on equity without too much debt are generally of good quality. All else being equal, a higher ROE is better.

But when a business is high quality, the market often bids it up to a price that reflects this. The rate at which profits are likely to grow, relative to the expectations of profit growth reflected in the current price, must be considered, too. So you might want to check this FREE visualization of analyst forecasts for the company.

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Of course, you might find a fantastic investment by looking elsewhere. So take a peek at this free list of interesting companies.

If you spot an error that warrants correction, please contact the editor at editorial-team@simplywallst.com. This article by Simply Wall St is general in nature. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. Simply Wall St has no position in the stocks mentioned.

We aim to bring you long-term focused research analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Thank you for reading.

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Is One Liberty Properties, Inc.'s (NYSE:OLP) ROE Of 6.4% Impressive? - Yahoo Finance

Liberty end up with 4 of top 12 picks after draft-night deals – ESPN

Apr 17, 2020

Mechelle VoepelESPN.com

The New York Liberty were involved in two trades on WNBA draft night, both bringing them forwards.

The Liberty received No. 10 pick Jocelyn Willoughby from Phoenix in exchange for the contract of guard Shatori Walker-Kimbrough. New York also got the contract of forward Stephanie Talbot from Minnesota in a swap for Rice guard Erica Ogwumike, who was the No. 26 pick by the Liberty.

With the trades, the Liberty ended up with four of the top 12 selections from Friday's draft and six overall. They acquired Oregon's Sabrina Ionescu at No. 1, UConn's Megan Walker at No. 9, Willoughby at No. 10, Louisville's Jazmine Jones at No. 12, Louisville's Kylee Shook at No. 13 and Duke's Leaonna Odom at No. 15.

2 Related

Willoughby, a 6-foot wing from Virginia, averaged 19.2 points per game this season for the Cavaliers.

Walker-Kimbrough, a former Maryland standout, played for the defending WNBA champion Washington Mystics the past three seasons and had been traded to New York this week as part of the Tina Charles deal. Walker-Kimbrough now joins the Mercury; the 5-foot-9 guard averaged 6.7 points last year.

Ogwumike averaged 19.0 points this season for the Owls, and she joins older sisters Nneka (2012) and Chiney (2014) Ogwumike in being selected in the WNBA draft. Nneka and Chiney were No. 1 picks, and both now play for the Los Angeles Sparks.

Talbot is a 6-foot-2 forward from Australia who averaged 5.2 points last season for the Lynx.

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Liberty end up with 4 of top 12 picks after draft-night deals - ESPN

Yes, government can restrict your liberty to protect public health – Los Angeles Times

Can the government restrict individual liberties to stop the spread of COVID-19? Its a question being raised by protesters and in lawsuits filed to contest government-imposed restrictions.

There have been very few Supreme Court cases involving the governments power to deal with the spread of communicable diseases. The most relevant decision for today was issued in Jacobson vs. Massachusetts in 1905. In that case, the Supreme Court upheld the constitutionality of a state law requiring compulsory vaccinations against smallpox. The court declared, Upon the principle of self-defense, of paramount necessity, a community has the right to protect itself against an epidemic of disease which threatens the safety of its members.

The court explicitly rejected the claim that liberty under the Constitution includes the right of individuals to make decisions about their own health in instances where those decisions could endanger others. But the court also made clear that restrictions imposed by the government to control communicable diseases must have a real or substantial relation to protecting public health.

Under this standard, there is no doubt that quarantine, shelter in place, and closure requirements are constitutional as a way of stopping the spread of COVID-19, even though they restrict freedom.

Throughout American history, quarantine orders have been upheld as valid exercises of the police power possessed by state and local governments. Not long after the Revolutionary War, Philadelphia imposed a quarantine to stop the spread of yellow fever. In 1799, Congress, by statute, recognized the power of states to impose quarantines. In 1926, the Supreme Court ruled that a state, in the exercise of its police power, may establish quarantines against human beings, or animals, or plants. Most recently, in 2016, a federal district court in New Jersey upheld a quarantine order for a nurse who had returned from Africa after treating Ebola patients.

The power to quarantine is not unlimited, however, and courts should invalidate orders that do not have a real and substantial relation to public health. In 1900, for example, a federal district court declared unconstitutional a quarantine order in San Francisco to stop the spread of bubonic plague because it was clear that it is made to operate against the Chinese population only and was based on racism, not public health needs.

At this stage, after a week when COVID-19 was second only to heart disease as the leading cause of death in the United States, courts unquestionably should uphold orders for quarantine, shelter in place, and closure of nonessential businesses. All are designed to stop the transmission of a highly communicable disease that, if left unchecked, could overwhelm the healthcare system.

These orders are constitutional even when they preclude people from assembling for religious worship. A number of lawsuits have been filed by those who wish to gather for religious services, saying they have a 1st Amendment right to gather. But the Supreme Court has been clear that there is no exception to general laws for religion. Moreover, if people gather in large groups for this or any other purpose there is the serious risk of spreading COVID-19.

But this does not mean that the government can do whatever it wants in the name of stopping the spread of a communicable disease. There is always a danger that government might use its power as an excuse for unnecessary restrictions on freedom. This has occurred during our current crisis in countries including Hungary, which canceled elections, and Thailand and Jordan, which have restricted speech critical of the government.

In the United States, a number of states have adopted regulations preventing abortions, including medically induced abortions that involve no surgical procedure at all. It is hard to see how such restrictions have a real and substantial relationship to stopping the spread of COVID-19 as opposed to attempts to use the crisis as a pretext for imposing additional limits on abortion.

And courts would probably look skeptically on banning a religious service if it involved people staying in their cars in a parking lot a drive-in service, as some churches have instituted. Such gatherings present no valid public health threat, since they do not involve interpersonal contact.

Still, most closure orders are clearly constitutional. The right to swing your fist stops at another persons nose. With coronavirus, your freedom stops when it endangers others by facilitating transmission of a highly communicable disease.

Erwin Chemerinsky is dean of the UC Berkeley School of Law and a contributing writer to Opinion.

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Yes, government can restrict your liberty to protect public health - Los Angeles Times

The Pandemic and the Global Economy – Dissent

Developing countries face collapsing international trade, falling remittances, sharp reversals of capital flows, and currency depreciation. Only bold policiesdebt relief, international financing, planning, and morewill avert further catastrophe.

There are still many uncertainties about the COVID-19 pandemic: about the extent of its spread, its severity in different countries, the length of the outbreak, and whether an initial decline could be followed by a recurrence. But some things are already certain: we know that the economic impact of this pandemic is already immense, dwarfing anything that we have experienced in living memory. The current shock to the global economy is certainly much bigger than that of the 2008 global financial crisis, and is likely to be more severe than the Great Depression. Even the two world wars of the twentieth century, while they disrupted supply chains and devastated physical infrastructure and populations, did not involve the restrictions on mobility and economic activity that are in place in the majority of countries today. This is therefore an unprecedented global challenge and requires unprecedented responses.

This very severe economic impact largely stems not from the pandemic itself, but from measures that have been adopted across the world to contain it, which have ranged from relatively mild restrictions on mobility and public gatherings to complete lockdowns (and clampdowns) that have brought to a halt most economic activity. This has meant a simultaneous attack on demand and supply. During lockdowns, people (especially those without formal work contracts) are deprived of incomes and joblessness increases drastically, causing huge declines in consumption demand that will continue into the period after the lockdown is lifted. At the same time, production and distribution are halted for all but essential commodities and servicesand even for these sectors, supply is badly affected because of implementation issues and inadequate attention to the input-output linkages that enable production and distribution. Previous regional and global crises have not entailed this near-cessation of all economic activity. The deadly combination of collapses in both demand and supply is why this time is truly different and has to be dealt with differently.

World trade in both goods and services is already collapsing. The WTO expects trade to fall anywhere between 13 and 32 percent over 2020. But even these dismal projections could well be underestimates, because they implicitly rely on relatively rapid containment of the virus and the lifting of lockdown measures by late summer. Exports of goodsother than those deemed essentialhave effectively ceased; travel has declined to a tiny fraction of what it was, and tourism has also stopped for the time being; various other cross-border services that cannot be delivered electronically are contracting sharply. Trade prices have collapsed and will continue to decline. In the month leading up to March 20, 2020, primary commodity prices fell by 37 percent, with energy and industrial metals prices falling by 55 percent.

Within countries, economic activity is contracting at hitherto unimaginable rates, bringing about not only a dramatic immediate collapse but the seeds of future contraction as negative multiplier effects start playing out. In the United States alone, around 22 million people lost their jobs in four weeks, with GDP estimated to contract by 10 to 14 percent from April to June. Elsewhere the pattern is no different, probably worse, as most countries are facing multiple forces of economic decline. The IMF predicted on April 14 that global output will fall by 3 percent in 2020, and as much as 4.5 percent in per capita termsand this is based on the most optimistic projections.

These collapses in economic activity necessarily affect global finance, which is also in disarray. The classic point about financial markets being imperfect not only because of asymmetric but also incomplete information is being borne out in practice: these markets are all about time, and now we must painfully accept that no one can know the future, even a few months ahead. Financial bets and contracts made just a few months ago now appear completely implausible to sustain. Most debts are clearly unpayable; insurance claims will be so extreme as to wipe out most insurers; stock markets are collapsing as investors realize that none of the assumptions on which earlier investments were made are valid anymore. These negative forces together amount to humongous losses that could threaten the very viability of the global capitalist order (an order that was already struggling to show any dynamism over the past decade).

In an already very unequal world, this crisis already has and will continue to sharply increase global inequality. A large part of this is because of the very different policy responses in most developing countries (other than China, the origin of the pandemic, which has managed to contain its spread and revive economic activity relatively quickly) as compared to advanced economies. The sheer enormity of the crisis has apparently registered with policymakers in the developed world, who have (probably temporarily) abandoned all talk of fiscal austerity and suddenly appear to have no problem simply monetizing their government deficits. It is likely that the global financial system would have collapsed in the panic that arose in the third week of March without massive intervention by the major central banks of the developed worldnot just the U.S. Federal Reserve but the European Central Bank, the Bank of Japan, the Bank of England, and others.

The exorbitant privilege of the United States as the holder of the worlds reserve currency obviously gives it greater freedom to prop up its own economy. But other developed countries are also putting forward fairly large fiscal packages, from 5 percent of GDP in Germany to 20 percent in Japan, in addition to various other expansionary and stabilizing measures through their central banks.

By contrast, most developing countries have much less leeway to engage in such policies, and even those larger developing economies that could do so appear to be constrained by the fear of financial markets punishing them further. This is terrible: their economic challenges are already much greater than those in the developed world. Developing countriesmany of which have yet to experience the full force of the spread of the virushave been hit by a perfect storm of collapsing global trade, falling remittances, sharp reversals of capital flows, and currency depreciation. In just the month of March, capital flight from emerging market assets was an estimated $83 billion, and since January nearly $100 billion has flown outcompared to $26 billion after the 2008 financial crisis. Portfolio investment is down by at least 70 percent from January to March 2020, and spreads on emerging market bonds have risen sharply. Currencies of developing countries have mostly depreciated sharply, other than in China. The foreign exchange crunch is generating serious problems in servicing external debt, which is harder to do because of shrinking foreign exchange inflows and rising domestic costs for servicing them. By early April, eighty-five countries had approached the IMF for emergency assistance because of severe problems in meeting foreign currency payment obligations, and that number is likely to rise.

These external pressures, which are already together much greater than anything experienced during the Great Depression, have come to bear on economies that are already struggling with the terrible domestic economic consequences of their virus containment strategies. The burden of these processes has fallen massively upon informal workers and self-employed people, who are being deprived of their livelihoods and falling into poverty at very rapid rates. Seventy percent of workers in developing countries are informal and are unlikely to be paid at all during lockdowns in which they are forced to be inactive. Workers with formal contracts have also started losing their jobs. The International Labour Organization estimated in early April that more than four out of every five workers in the world are facing the adverse impacts of the pandemic and associated policy responses, and most of them reside in the developing world. Women workers are more likely to be disproportionately adversely affected: more likely to lose jobs and experience major pay cuts, more likely to be rationed out of labor markets when jobs do become available, more likely to suffer during lockdowns because of enhanced possibilities of domestic abuse, and more likely to suffer from inadequate nutrition in a time of household food shortages.

In many countries, livelihood losses are associated with dramatic increases in the extent of absolute poverty and growing hunger, even among those previously not classified as poor. Indeed, the re-emergence of hunger on a global scale is likely to be an unfortunate legacy of the pandemic and the containment measures that resulted. To add to all of this depressing news, most states in developing countries will not be able to indulge in the necessary levels of deficit financing (by borrowing from central banks) to enable the required increases in public expenditure, because of foreign exchange constraints and greater surveillance of financial markets over their deficits.

This, unfortunately, is just the beginning. What of the aftermath, when the pandemic is brought under control? It bears reiterating that after a seismic shock of this magnitude, economies across the world will not simply be able to carry on as before, picking up where they had left off before this crisis. Over the coming year, many things are likely to change, including global reorganization of trade and capital flows. International trade will remain subdued for a while. Most commodity prices will also remain low, because global demand will take some time to pick up. This will affect commodity exporters revenues, but it need not provide much advantage for commodity importers because of the overall deflationary pressures stemming from depressed demand.

On the other hand, the breaking of supply chains could well lead to specific shortages, including of some essential items, generating cost-push inflation especially in developing countries. Cross-border capital flows will be volatile and unstable, and most developing countries will struggle to attract sufficient secure capital on terms that would make it beneficial to add to domestic savings and meet trade financing costs. The steep currency depreciations that have already occurred are unlikely to get completely reversed and could even accelerate further, depending upon what strategies are pursued in both developed and developing countries. These falling currency values, higher margins on interest paid, and rising yields on bonds will all continue to make debt servicing a massive problem. Indeed, most developing country debt will be simply unpayable.

In addition to problems in domestic banks and non-bank lenders because of likely large-scale defaults, there will be massive problems in insurance markets, with the failure of some insurance companies and rising premiums that could be a disincentive for most medium and small enterprises to be insured at all. Travel and tourism revenues will also be significantly curtailed over the medium term, as the earlier confidence underlying such travel will have eroded. Similarly, many migrants will have lost employment. Demand for foreign labor is likely to decline in many host countries, so remittances will also decline. All of this will continue to put pressure on government finances especially (but not only) in the developing world.

This litany of horrors is well within the realm of the possible. The saving grace is that these outcomes are not inevitable: they depend crucially on policy responses. The terrible consequences described above are predicated on international institutions and national governments not taking the measures that could ameliorate the situation. There are both national and global policies that could help, but they must be implemented quickly, before the crisis generates even more humanitarian catastrophe. It is essential to ensure that the policy responses do not (as they currently do) increase national and global inequalities. This means that recovery strategies must be reoriented away from handouts to large corporations without adequate regulation of their activities, and toward enabling the survival, employment, and continued consumption demand of poor and middle income groups, and the survival and expansion of tiny, small, and medium enterprises.

There are some obvious steps that the international community needs to take immediately. These steps rely on the existing global financial architecturenot because this architecture is just, fair, or efficient (it is not), but because, given the need for a speedy and substantial response, there is simply no possibility of constructing meaningful alternative institutions and arrangements quickly enough. The existing institutionsespecially the International Monetary Fundhave to deliver, which requires that they shed their pro-capital bias and their promotion of fiscal austerity.

The IMF is the only multilateral institution that has the capacity to create global liquidity, and this is the moment when it must do so at scale. An immediate issue of Special Drawing Rights (SDRs), which are supplementary reserve assets (determined by a weighted basket of five major currencies), would create additional international liquidity at no extra cost. Since a fresh issue of SDRs must be distributed according to each countrys quota in the IMF, it cannot be discretionary and cannot be subject to other kinds of conditionality or political pressure. At least 1 to 2 trillion SDRs must be created and distributed. This will have a huge impact in ensuring that global international economic transactions simply do not seize up even after the lockdowns are lifted, and that developing countries are able to engage in international trade. Advanced economies with international reserve currencies are much less likely to need to use them, but they can be a lifeline for emerging markets and developing economies, providing additional resources to fight both the pandemic and the economic disaster. They are much better than depending on the IMF to provide loans, which often require conditionalities. (Insofar as additional emergency loans from the IMF are required, they must also be provided without conditionality, as purely compensatory financing for this unprecedented shock.) The issuance of more SDRs is also preferable to allowing the U.S. Federal Reserve to play the role of sole stabilizer of the system. The Feds swap lines are currently providing central banks of a few chosen countries with dollar liquidity as it becomes scarce in this crisis. But this is not a norm-based multilateral allocation; these swaps reflect the strategic national interests of the United States, and therefore reinforce global power imbalances.

One reason why there has been only limited issue of SDRs so far (the last increase was after the 2008 crisis, but to the tune of only around 276 billion SDRs) is the fear that such an increase in global liquidity would stoke inflation. But the world economy has just experienced more than a decade of the largest increases in liquidity ever due to quantitative easing by the U.S. Fed without inflation, because global demand remained low. The current situation is only different because it is more acute. If additional liquidity is used to invest in activities that would ease the supply shortages likely to come up because of lockdowns, then it could also ease any cost-push inflation that might emerge.

The second important international measure is dealing with external debt problems. There should immediately be a moratorium or standstill on all debt repayments (both principal and interest) for at least the next six months as countries cope with both the spread of the disease and the lockdown effects. This moratorium should also ensure that interest payments do not accrue over this period. It is obvious that very few developing countries will be in any position to service their loans when foreign exchange inflows have effectively stopped. But in any case, if everything else is on hold in the global economy today, why should debt payments be any different?

A moratorium is a temporary move to tide these countries over during the period when the pandemic and the closures are at their peaks. But eventually substantial debt restructuring is likely to be necessary, and very substantial debt relief must be provided especially to low-income and middle-income countries. International coordination would be much better for all concerned than the disorderly debt defaults that would otherwise be almost inevitable.

Within nation-states, the institution of capital controls would enable developing countries to deal at least partly with these global headwinds by stemming the volatility of cross-border financial flows. Such capital controls must be explicitly allowed and encouraged, in order to curtail the surge in outflows, to reduce illiquidity driven by sell-offs in emerging markets, and to arrest declines in currency and asset prices. Ideally, there should be some cooperation among countries to prevent any one country from being singled out by financial markets.

The aftermath of this crisis is also going to require a revival of planningsomething that had almost been forgotten in too many countries in the neoliberal era. The collapse of production and distribution channels during lockdowns means that defining and maintaining the supply of essential commodities is of critical importance. Such supply chains will have to be thought through in terms of the input-output relationships involved, which in turn requires coordination between different levels and departments in governments as well as across provincesand possibly at the regional level as well.

The pandemic is likely to bring about a change in attitudes to public health in almost all countries. Decades of neoliberal policy hegemony have led to drastic declines in per capita public health spending in rich and poor countries alike. It is now more than obvious that this was not just an unequal and unjust strategy but a stupid one: it has taken an infectious disease to drive home the point that the health of the elite ultimately depends on the health of the poorest members of society. Those who advocated reduced public health spending and privatization of health services did so at their own peril. This is true at a global scale as well. The current pathetically nationalist squabbles over access to protective equipment and drugs betray a complete lack of awareness of the nature of the beast. This disease will not be brought under control unless it is brought under control everywhere. International cooperation is not just desirable but essential.

While pushing for these major strategies for national governments and international organizations, we need to be conscious of some concerns. One is the fear that governments across the world will use the opportunity presented by the pandemic to push for the centralization of power, with significantly increased monitoring and surveillance of citizens, and increased censorship and control over information flows to reduce their own accountability. This has already started in many countries, and fear of infection is causing many people across the world to accept invasions of privacy and forms of state control over individual lives that months ago would have been seen as unacceptable. It will be harder to sustain or revive democracy in such conditions. Much greater public vigilance is required both at present and after the crisis has ended.

There is also a fear that the increased inequalities thrown up by this crisis will reinforce existing forms of social discrimination. In principle, a virus does not respect class or other socio-economic distinctions. But there are well-known negative feedback loops between the squalor associated with income poverty and infectious diseases. In our unequal societies, poor and socially disadvantaged groups are more likely to be exposed to COVID-19 and more likely to die from it, because peoples ability to take preventive measures, their susceptibility to disease, and their access to treatment all vary greatly according to income, assets, occupation, and location. Perhaps even worse, COVID-19 containment policies within countries show extreme class bias. Social distancing (better described as physical distancing) implicitly assumes that both residences and workplaces are not so crowded and congested that the prescribed norms can be easily maintained, and that other essentials like access to soap and water are not limited. The fear of infection during the pandemic has brought out some more unpleasant forms of social discrimination and prejudice in many countries, from antipathy to migrants to differentiation on the basis of race, caste, religion, and class. At a time when the universality of the human condition is highlighted by a virus, responses in too many countries have been focused on particularistic divisions, which bode ill for future progress.

Despite these depressing possibilities, it is also true that the pandemic, and even the massive economic crisis it has brought in its wake, could also bring about some changes in attitudes that point to a more hopeful future. Three aspects of this deserve comment.

The first is the recognition of the essential nature and social significance of care work and the greater respect and dignity accorded to paid and unpaid care workers. This could result in societies increasing the number of paid care workers, providing required training for them because of greater appreciation of the skills involved in such labor, and offering these workers better remuneration, more legal and social protection, and greater dignity.

Second, the wider realization among the public of the real possibility that unthinkable events can occur and unimaginably dreadful processes can be unleashed by our ways of life may also bring home the reality of climate change and the disasters it will bring in its wake. This could make more people conscious of the need to change how we live, produce, and consume, before it is too late. Some of the less rational aspects of global supply chains, especially in the multinational food industry (which has encouraged produce from one part of the world to be shipped to another part of the world for processing, before coming back to places near its origin to be consumed), will be questioned and could decline in significance. Other changes in lifestyle and consumption and distribution patterns could follow.

Finally, on a more philosophical level, existential threats like pandemics encourage more recognition of the things that really matter in human existence: good health, the ability to communicate and interact with other people, and participation in creative processes that bring joy and satisfaction. These realizations could encourage the first steps toward civilizational shifts that lead to the reorganization of our societies. There is an opportunity to move away from dominant assumptions about individualistic utility maximization and the profit motive to more caring and cooperative social frameworks.

Jayati Ghosh is a professor of economics at Jawaharlal Nehru University in New Delhi, India.

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The Pandemic and the Global Economy - Dissent