Lebanon: Financial Collapse, Revolution, and Pandemic: Where are the Unions? – prruk.org

If the last six months in Lebanon have taught us anything about extraordinary timeswhether financial collapse, revolutionary moments, or pandemic wavesit is the centrality of having grassroots organizations that can play an important role in protecting collective interests, providing social safety nets, and envisioning alternatives that hold social justice at their core. At a time when the economic situation is in a free fall, and people are requested to stay home in order to contain the pandemic, the elephant in the room remains the social and economic consequences of such a measure. After all, a pandemic does not only require medical and public health interventions, but also social, political, and economic plans that can uphold society in such difficult times, especially as this hits in an already collapsing economy.

Several weeks into the lockdown in Lebanon, the government has only taken very slow and limited measures to protect what they qualify as being the poorest. Of course, this gave roomintentionally, I would argueto sectarian leaders to resurface with their clientelism in the form of donation boxes. But in times like these, social protection cannot be equated to a charity program targeting the poor. Given the magnitude of the crisis, it is society at large that needs protection, and with it, a broader vision is required in order to get out of the multiple crises the country is going through simultaneously. Who will protect the daily wage workers who have lost their jobs due to the lockdown? The unemployed who have no social protection? The workers and employees who have been laid off? The employees who have lost more than half of their salaries because of the financial crisis? Who will protect domestic workers or migrant workers? What about the medical staff that are risking their lives to save ours? The cleaners, garbage collectors, and delivery workers who have been our essential workers, keeping us clean and safe in our houses, while being exploited and underpaid? Who will protect people who are unable to pay their rent? Or those who are unable to put food on their tables anymore? Who will protect the owners of small businesses who are unable to make ends meet anymore? After all, werent the youth encouraged for decades to be entrepreneurs and create their own businesses? Who protects them now that their small investments have only resulted in debts and losses? These social categories do not all qualify as the poorest, but they all require immediate social protection in the form of social justice, not charity.

One of the main predicaments of the Lebanese uprising and the current COVID-19 pandemic lockdown is the absence of strong and active unions and labor organizations. It is in times like these that unions and syndicates play a crucial role in protecting the interests of most people in society, and take a leading role in pushing for social and economic plans that guarantee social protection.

Why Labor Organizations?

While some consider it to be old school to insist on the importance of labor organizations, an informed reading of socio-economic and political dynamics in Lebanon points to the centrality of such types of organizations in challenging the existing neoliberal-sectarian regime. It is not a coincidence that the post-civil war era in Lebanon was marked by a systematic and violent crackdown on unions that led, by the end of the 1990s, to a full cooptation of the General Confederation of Workers (GCWL), the countrys national trade union center. Similarly, professional orders were also dominated by sectarian party politics, and played an important role in upholding the interests of the ruling elites.

The post-war neoliberal rolling back of the state and the flourishing of non-state welfare in the form of clientelism created a system of inequality whereas only party partisans can potentially benefit. It is a system where bankers, businessmen, and sectarian leaders are able to accumulate wealth and exploit workers and employees with little to no resistance from below. The weakening of the unions meant that the power of collective bargaining and the struggle for social justice were made impossible. In such context, two types of activism flourished in post-war Lebanon: Sect-based mobilization (mainly in the form of political parties) and issue-based campaigns (mainly taking the shape of civil society activism). Despite their seemingly opposite paths, both streams have contributeddirectly or indirectlyto the reproduction of the neoliberal-sectarian regime through the fragmentation of causes, the elevation of identity politics, and the professionalization of issue-based activism without ever questioning the very structure of the political or economic system.

Therefore, it is only when society starts to organize along class interests and to demand social justice by questioning the accumulation of wealth or by pushing for social protection as a right for all, rather than clientelism, that the regime is really threatened in its core. This is not an overstatement of the power of the people, but rather a reminder of the understated power of organization that is interest-based. The mobilization of the Union Coordination Committee in 2012, which aimed to improve working conditions of civil servants and teachers, is one such example of the power of alternative unions to pressure and to achieve benefits that contribute to social protectiondespite the unfortunate crackdown that brought the movement to a halt in 2014.

Revival of Labor and Professional Organizations since October 2019

Since the start of the uprising in October 2019, new groups of workers, employees, and professionals started to emerge. While these movements were mainly spontaneous and largely unorganized, the severity of the financial crisis and its catastrophic implication on the labor market pushed employees to come together on many occasions, either informally or through pre-existing unions, to protect their rights and to collectively negotiate salaries and benefits.

As expected, the official GCWL did not mobilize in the uprising, and professional orders also remained widely silent and at the margin of the historic events. It was only after the election of an independent candidate as president of the Beirut Bar Association that the role of professional orders in the uprising surfaced. Simultaneously, new bodies of shadow unions or professional associations started to take shape and to organize as alternatives to the coopted and dysfunctional syndicates and orders. Clearly inspired by the Sudanese Professionals Association, a new Association of Professionals ( ) was declared on 28 October, calling on professionals, employees, and workers to organize in their workplaces, and to couple the political struggle with a socio-economic struggle that brings back the question of labor and social justice to the core.

While such initiatives can play a crucial role in the unfolding of the uprising, their success in revamping the role of syndicates and creating a nationwide labor movement will largely depend on their ability to organize in a democratic and coherent way. These nascent organizations are now faced with the sudden shift to work from home for many employees, and the emergency of essential workers to report to work without interruption. In such difficult and unusual times, the challenge becomes to come up with a new repertoire of contention that can devise tactics of organizing and mobilizing that pressure for bargaining and protecting labor rights and social safety nets.

Moreover, such initiatives should also make room for types of organization that are not merely traditional labor unions or professional associations. For example, given the prevalence of the informal sector in Lebanon and the high rates of unemployment, it would make sense for these groups in society to organize based on informality or unemployment. Such organizations are crucial for social protection since they would raise very important demands such as the right to unemployment benefits, which would limit clientelism and youth migration, or the right to free universal healthcare. Had we organized and activated such unions and associations long before, the response to the COVID-19 pandemic at the social and economic level would have been much different today.

Finally, building a strong and independent labor movement is crucial to channel the popular demands of the October uprising for social justice into a political project that can have serious leverage in the balance of power between the regime and the people. Looking at the experiences of the Arab uprisings over the past decade, it becomes clear that the only two countries that were able to build on their popular upheavals to launch a somehow democratic transitional political process were Tunisia and Sudan. In both cases, labor unions and professional associations played a key role.

Imagining a political transition in Lebanon toward a more just and fair system will surely require unions and syndicates to play a central role. This is even more crucial today, at a time when the whole world will be going into a recession and when opportunities for exporting our youth to work abroadas has been the Lebanese formula for decadeswill be shrinking considerably. Protecting society means organizing based on our interests as workers, employees, unemployed, or underemployed. After all, a job and a decent income are a right, not a privilege; and the core of the problem is in the distribution of wealth, not in its existence.

Rima Majed is Assistant Professor of Sociology at American University of Beirut and LCPS research fellow.

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Lebanon: Financial Collapse, Revolution, and Pandemic: Where are the Unions? - prruk.org

United Nations Statement to the Development Committee – UNDP

We will not and cannot return to the world as it was before the pandemic struck. We must rebuild societies that are better, more resilient and we must do so together.Secretary General Antonio Guterres

The unprecedented crisis triggered by the spread of the COVID-19 virus, has focused the full attention of the United Nations System (UN) on a strategy of rapid response and recovery. In the words of the UN Secretary-General, this pandemic is the worst global crisis since World War II. The IMFs World Economic Outlook frames the depth of the current global economic recession as the deepest since the Great Depression.

I. Introduction: The COVID Response

The UNs efforts to help save lives and protect people from the COVID-19 pandemic focus on three critical components, all led by each countrys Resident Coordinator: the health response, coordinated by the World Health Organisation (WHO); the humanitarian response, coordinated by the Office for the Coordination of Humanitarian Affairs (OCHA); and the socio-economic response, coordinated by the UN Development Programme (UNDP) in close collaboration with all UN agencies in 162 countries and territories.

In a recent report entitled Shared responsibility, global solidarity: Responding to the socio-economic impacts of COVID-19, the UN Secretary-General calls for a large-scale, coordinated, comprehensive multilateral response that amounts to at least 10 per cent of GDP. The size of this commitment requires an open discussion about debt relief in all developing countries in fragile/crisis contexts, in low and middle-income countries as well as in Small Island Developing States.

While its impact will vary from country to country, Covid-19 will likely increase poverty and inequalities at a global scale. According to the UN International Labour Organization, working hours are projected to decline by 6.7% in Q2 (2020), equivalent to 195 million full-time workers, with the world losing between $860 billion to $3.4 trillion in labor income. The UN Conference on Trade and Development projects 30 to 40 per cent downward pressure on global foreign direct investment flows. The World Tourism Organization sees a 2030 per cent decline in international arrivals. The UN Educational, Scientific and Cultural Organization forecasts that 1.5 billion students will be out of school. Inequality of access to broadband connectivity and inaccessibility of ICTs hinders effective remote participation and access to remote schooling arrangements, health information and telemedicine by all. According to the International Telecommunication Union, an estimated 3.6 billion people remain offline, with most of the unconnected living in the least developed countries.

To operationalise the UN Secretary-Generals report, the UN development system has developed a socio-economic response framework and has switched into emergency mode. A significant portion of the UNs existing portfolio of sustainable development programmes of a total of $17.8 billion across all the SDGs is being adjusted and expanded towards COVID-19 related needs, in close collaboration with programme countries, donors and partners.

II. The Socio-Economic Response

The UNs response to the socio-economic impact of the COVID-19 crisis considers a variety of interlinked dimensions that need to be addressed in an integrated manner to protect the needs and rights of people living under the duress of the pandemic, with particular focus on the most vulnerable countries, groups, and people who risk being left behind.

1. HEALTH FIRST: PROTECT AND STRENGTHEN THE HEALTH SYSTEM: Health systems are being overwhelmed by demand for services generated by the COVID-19 outbreak. When health systems collapse, both direct mortality from the outbreak and avertable mortality from vaccine and other care interventions, preventable and treatable conditions increase dramatically. At least half of the worlds population still do not have full coverage of essential health services and about 100 million people are still being pushed into extreme poverty (defined as living on 1.90 USD or less a day) because they have to pay for health care. Over 930 million people (around 12% of the worlds population) spend at least 10% of their household budgets to pay for health care.

Countries with the weakest health systems stand before huge challenges in all these aspects. There must be immediate, targeted actions to allow countries to maintain essential lifesaving health services even as they surge to meet the spike in demand for acute care. And there must be a complementary effort on health systems recovery, preparedness and strengthening with a focus on primary health care and Universal Health Coverage (UHC). Massive investment in health will be needed for both, maintaining services and to strengthen preparedness of health systems to respond to future waves of COVID-19 and future global outbreaks.

2. PROTECT PEOPLE: SOCIAL PROTECTION AND BASIC SERVICES: The COVID-19 crisis impacts the worlds poorest and most vulnerable. The crisis will devastate incomes and access to basic services with intergenerational implications for families on multidimensional poverty and inequality. Many governments are responding to the crisis by expanding existing programmes, but 4 billion people accounting for 71% of the world population, including 2 out of 3 children have no or inadequate social protection to start with. Therefore, the scope of the challenges ahead requires an extraordinary scale up of the response. Those with informal or unstable employment, entrepreneurs and those working in the service industry (majority women) are most affected, with only 1 in 5 unemployed persons able to avail of unemployment benefits. Social protection responses must consider differentiated impacts of COVID-19 on vulnerable groups and women and men.

Access to social services is being curtailed either through reduction in services or in access. Key areas include: (a) Food and Nutrition: The disruption of markets impacts on the quality of diets and nutrition practices, which translate into an increase of mortality, morbidity and malnutrition among the population groups with the highest nutrition needs; (b) Education: About 90% of the total number of school children in the world have been directly affected by school closures, with an estimated 370 million school children also missing out on school meals. Adolescent girls already lack access to secondary education and are at heightened risk; (c) Water and sanitation: WASH services will be affected with public utilities potentially facing less than optimal staffing and available workforce, disrupted supply chains, and challenges in payments to support functionality putting these services at grave risk of collapsing. Women-headed households are more likely to have inadequate housing, including on water and sanitation, which can increase health risks, especially in cases of overcrowding of shelters; (d) Gender-Based Violence (GBV): Quarantine and isolation policies, coupled with financial stress on families, individuals and communities, will exacerbate the conditions for women already vulnerable to domestic violence, estimated to be at least one third of all women. Care and support to GBV survivors may be disrupted when health service providers are overburdened; (e) Protection, mental health and psychosocial support: Fear, worry and acute stressors can lead to long-term consequences, coupled with diminished availability to services from social workers and case workers, leaving women and the most vulnerable exposed to violence, abuse, exploitation and neglect.

3.PROTECT JOBS AND ECONOMIC RECOVERIES: COVID-19 has plunged the world economy into a recession with deep consequences and historical levels of unemployment and deprivation. It is estimated that we could lose 25 million jobs and see losses in labour income in the range of USD 860 billion to USD 3.4 trillion. Small and medium enterprises, the self-employed, daily wage earners and migrant workers are hit the hardest. Supporting income and employment for workers needs to be a core element of stimulus packages. Most vulnerable workers are in the informal economy, with no or limited access to social protection, nor do they have the economic security to take sick leave, get treated if required, or cope with lockdown. Women represent approximately 70 per cent of frontline workers dealing with the pandemic in the health and social sector, many of whom are migrant workers. Women are also overrepresented in some of the services sectors most impacted by the crisis, mostly lacking social protection, and will also bear a disproportionate burden in the care economy.

Economic recovery is about protecting critical productive assets, productive units and productive networks during the crisis. Ensuring the continued or improved functioning of SMEs across sectors, including food and other essential goods and services supply chains, is of particular urgency. First, policy actions across multiple sectors and mitigation of adverse policy effects on essential services are needed to avoid disruption and permanent job losses. Second, employment crises are the harbingers of political crises. Disruptions in massive employment sectors presents immediate existential threats to essential services that result in riots, violence and erosion of trust in institutions and governments. Third, a global economic recession will impact global population movements and hence affect countries with high levels of migration and large portions of remittances in their GDP. The return of migrants and the reduction of remittances will likely surpass the capacity of the formal and informal sectors in those countries to absorb large numbers of returnees or additional local job seekers in the local labour market.

4.THE MACROECONOMIC RESPONSE AND MULTILATERAL COORDINATION: A major global economic recession is underway, along with the possibility of a financial crisis, with major implications for vulnerable population groups and households. A large-scale fiscal and financial effort for counter-cyclical spending is urgently needed everywhere.

A three-step strategy is essential for the socio-economic response to the COVID-19 crisis. First, a rapid assessment of the potential impact of the crisis is needed in order to quantify the spending necessary to contain it. Second, an assessment of the fiscal space available to finance increased spending, as it will restrict the governments capacity for action. Third, an analysis of policy priorities and available policy measures considering both financing and implementation constraints faced by governments. The possible implications of the proposed policy measures will need to be accounted for as well.

As the UN Secretary-General has noted, a large scale, coordinated and comprehensive multilateral response is needed now more than ever. COVID-19 is a global problem and confronting the effects of the pandemic will require global and coordinated efforts supported by regional initiatives and regional institutions. While the level and intensity of the impact of COVID-19 varies across the world, countries under sanctions may be particularly affected. Three areas of regional coordination are particularly relevant: trade policy, monetary coordination and enhanced connectivity.

5.SOCIAL COHESION AND COMMUNITY RESILENCE: The impact of COVID-19 on the life of rural and urban communities is set to be massive, particularly in poor and densely populated urban areas and slums. 1 billion people live in slums, where living conditions affect the health of the urban poor dramatically, where people are unable to self-isolate and where their livelihood depends on income from day to day work in the informal sector.

The scale of the socio-economic impact of COVID19 on the urban and rural poor will largely depend on tailored solutions for these communities. This will require a close interaction between national, subnational and local Governments and communities, based on a good understanding of the specific situations of communities through local assessments, strengthen community-led advocacy and service delivery. It will also require that communities are empowered to participate in local planning and in the oversight of services.

The COVID-19 crisis also threatens social cohesion as the crisis can erode trust within society and with respect to governments. Whole-of-society approaches are essential to confront the socio-economic impacts of the crisis. Social cohesion, embedded in actors, communities and institutions, holds the society together and is critical to the achievement of the SDGs, advancing the values, norms and fundamental human rights. Close attention should be paid to the impact of COVID-19 on fragile political transitions and in countries already facing a rapid deterioration of security conditions, on top of weak health systems and climate change.

III. A focus on debt

The size of fiscal and financial stimulus needed in each country - short run measures to address the pandemic, and fiscal policy to spur demand in the medium run - is in the order of several percentage points of GDP. Yet, many developing countries, including low- and middle-income countries, fragile/crisis context countries and Small Island Development States, will be unable to raise the resources needed.

Even before the COVID-19 pandemic, global debt had reached record highs. As the UN 2020 Financing for Sustainable Development Report points out, the long period of unusually low international interest rates and unprecedented levels of global liquidity associated with quantitative easing gave developing countries, including least developed countries, increased access to commercial financing. While providing much needed resources in the short term, this has also resulted in higher debt servicing costs, and heightened interest rate, exchange rate and rollover risks. Forty-four per cent of least developed countries and other low-income developing countries were already at high risk of external debt distress or already in debt distress prior to the outbreak of the pandemic.

A UN proposal: Debt relief should not be based on level of income but on vulnerability

The global COVID-19-induced contraction in economic activity is having dire consequences, including on debt sustainability. This is not limited to low-income countries. Middle-income countries, home to 75% of the worlds population and 62% of the worlds poor, are highly vulnerable to a debt crisis, lost market access and capital outflows. Small Island Developing States face structural constraints on growth, energy and food imports, and fiscal space that need to be addressed in comprehensive fashion.

Principles for Global Solidarity

To effectively halt a debt crisis, we need to move quickly. We propose a framework that aims to ensure debt relief, while accounting for heterogeneous debt situations across countries and the need for tailored policy responses.

This approach builds on principles for debt sustainability discussed and agreed at the United Nations and laid out most recently in the Addis Ababa Action Agenda. They also reflect best practices underlying debt resolution at the IMF and the World Bank.

These include:

i) Debtors and creditors must share responsibility for preventing and resolving unsustainable debt situations

ii) Debt restructurings should be timely, orderly, effective, fair and negotiated in good faith

iii) Debt workouts should aim to restore public debt sustainability, while enhancing the ability of countries to achieve sustainable development, growth with greater equality and the sustainable development goals.

A Three Phase Approach

A comprehensive approach across three phases, involving all relevant creditors and all countries facing liquidity and solvency issues due to the crisis is required.

Phase 1

An across-the-board debt standstill for two years for all developing countries who cannot service their debt and request relief should be instituted. To start, official bilateral creditors should immediately institute an emergency debt payment moratorium on sovereign debt.

The standstill should also:

Include other creditors (private creditors as well as multilaterals). Coordination is of the essence.

Extend beyond IDA countries to include other low-income and those heavily indebted middle-income countries that request relief.

Include principal and interest payments, as well as associated fees and charges

Set a cut-off date, after which new financing is excluded from future debt restructurings, in order to facilitate access to financing after this date.

Allow for repayment schedules that ensure ability of countries to implement the 2030 Sustainable Development Agenda.

Phase 2

A second phase should consider a more comprehensive assessment and options towards debt sustainability. Debt swaps can release resources for the COVID-19 response in developing countries, although they may not adequately solve unsustainable debt situations.

A debt mechanism for the SDGs, with a focus on creating fiscal space for recovery in a resilient manner and SDG achievement could be considered.

Phase 3

Addressing long outstanding issues in the international debt architecture should be cast as a third phase given the urgency and immediacy of the need to act in the face of COVID.

This new international debt architecture should build upon the Principles established in the Financing for Sustainable Development Agenda of timely, orderly, effective, fair resolutions. It should aim at preventing defaults from turning into prolonged financial and economic crises, restoring public debt sustainability, and enhancing the ability of countries to achieve the sustainable development goals.

IV. Next Steps

The pandemic has reminded us, in the starkest way possible, of the price we pay for weaknesses in health systems, social protections and public services. It has underscored and exacerbated inequalities, above all gender inequality, laying bare the way in which the formal economy has been sustained on the back of invisible and unpaid care labour. It has highlighted ongoing human rights challenges, including stigma and violence against women.

Building a better, post-pandemic future will require social and economic interventions today that build greater resilience tomorrow. To be resilient, COVID-19 recovery efforts must be part of the solution to climate change the other global crisis facing this generation. They must accelerate rather than undermine decarbonization, the protection of natural capital, social equality and inclusion, the realization of human rights for everyone, and strong, capable governments and institutions all critical, systemic elements to avoiding such an outbreak again.

Rather than being put aside as aspirational in a time of crisis, the SDGs offer a framework for a fair and sustainable transition, as they recognize the interconnected nature of all life on this planet. Beyond the socio-economic frame of the current response, the role the environment and natural capital will play in the path to recovery is a policy choice that warrants further elaboration, as do good governance, gender equality and empowerment, and the protection and promotion of human rights for all.

As the UN Secretary-General report avers, we need to build back better. A large-scale, coordinated and comprehensive multilateral response is needed now more than ever. The COVID-19 crisis is a global problem and confronting the effects of the pandemic will require global and coordinated efforts supported by regional and sub-regional collaboration.

The UN is fully mobilized. It will make full use of its programmatic assets, contribute through actions that enable and empower, and through words that connect and protect with the SDGs as compass. It is also establishing a new Multi-Partner Trust Fund for COVID19 Response and Recovery. The collective know-how of the UNs Country Teams is operational and mobilized to implement this strategy over the next 12 to 18 months, led by Resident Coordinators in 162 countries and territories, and supported by a global and regional network of expertise and experience.

There will be no return to the old normal. The massive fiscal and financial repurposing made by governments in these weeks and months, including the redirection of fossil fuel subsidies to aid the response, are a glimpse of the future. They suggest that the status quo and business-as-usual are policy choices, not inevitable constraints on sustainable development.

Recovering from this pandemic must not come at the expense of tackling others. We need to do everything possible to ensure that our efforts to support countries ravaged by Covid-19 do not divert resources from existing crises addressing the needs of refugees and other vulnerable groups; tackling the global climate emergency; ending violence against women and girls; and putting an end to discrimination in all its forms. How stimulus plans are implemented matters to what this recovery will look like. The global recovery needs to be fair; it needs to be green, and above all, it must be inclusive.

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United Nations Statement to the Development Committee - UNDP

The Analytical Angle: How smart containment, along with active learning, can help mitigate the Covid-19 crisis – DAWN.com

Policymakers must be empowered down to the district levels to respond differentially based on local data.

Governments across the world face a near impossible choice in tackling the Covid-19 virus lockdown and prevent spread, but risk economic collapse and potentially many dying of non-Covid-19 reasons, or remain (mostly) open to minimise the socio-economic fallout, but risk many dying of Covid-19.

To make matters worse, there is little data to base a policy response on. Our knowledge of this new virus (transmission mechanisms, environmental triggers, immunity, etc) is still nascent and fast evolving. We also dont know enough about the potential adverse socio-economic and health impacts of the proposed public health policies. While many countries in the developed world have gone down the route of blanket lockdowns, for others, the choice is harder to make.

Physical distancing and locking down will be particularly damaging for the developing world. In Pakistan, much of the economy is informal. According to the Labour Force Survey 2017-18, the informal sector accounts for 72 per cent of non-agricultural employment. This makes it harder to target and provide financial assistance to those who may need it most.

Loss of livelihood and severe financial hardships may be accompanied by food shortages. In South Asia, food supply chains are dominated by labour-intensive SMEs. This means that extended lockdowns and quarantines may result in food supply disruptions especially in midstream and downstream segments retail, food service, distribution.

Health issues which require regular care are widely prevalent in Pakistan. The World Health Organisation characterises Pakistan as a TB high-burden country with the fourth highest prevalence of multi-drug resistant TB globally. In young children, diarrhoea is still a major killer, and malnutrition and stunting are persistent problems. Maternal deaths due to preventable causes prevail and half of women of reproductive age are anaemic.

The impact of Covid-19 policies on an already weak and over-stressed healthcare system must be well thought out. Managing health conditions in a lockdown may be difficult. Conversely, easing distancing measures may be too risky as the high prevalence of these health conditions in some populations makes them highly vulnerable to the Covid-19 virus.

Fiscal space is severely limited for adequate relief measures and countercyclical policies which will be required as the economy comes to a grinding halt. Weak state capacity may also make it nearly impossible to implement and enforce a country-wide lockdown, while ensuring all citizens are taken care of.

Understandably, these are very tough decisions to make. While the fear of uncontrolled spread and mortality eventually pushed the government out of paralysis, at times it also led to panic and poorly thought out decisions. The decision to expand the Ehsaas programme, for example, was a good one but the execution was poorly thought out with massive crowding outside distribution points.

The decision to ease the lockdown and open up some industries is also a controversial one especially with little transparency on the criteria being used to strengthen or ease the lockdowns.

In Pakistan this crisis has also become politicised resulting in misalignment of strategies across government tiers. The enormity of this challenge requires cooperation rather than tribalism. Our leaders need to work together to save lives and build resilient systems for the long-term.

Up till now the choice has largely been presented as a binary: Lockdown and prevent spread but risk economic collapse, loss of livelihoods, and deaths from other preventable reasons; or remain open to minimise this socioeconomic disaster, but risk health systems buckling and thousands dying from the virus.

Read: A better response to the Covid-19 challenge lies in smart lockdown strategies

Given the dearth of data, however, we are driving blind: we just dont know enough about the health and economic impact to figure out the trade-offs between these choices. How can we make better decisions in the face of such great uncertainty?

The crux of our approach is the importance of learning. Governments must draw on a well-developed and well-tested machinery for how to make decisions under uncertainty. Policy actions should inform our learning so that policies are tested and refined in real-time. This is what we call smart containment with active learning.

While some decisions must be made immediately (such as, increasing testing capacity and personal protective equipment for health workers), others may be better made after collecting some information (such as, socio-economic data to better target the relief response). Many decisions may also be refined over time as more information comes in (such as, which specific aspects of distancing and lockdown strategies are most effective).

The smart containment approach allows for a locally heterogeneous policy response each area may have different prevalence, and different needs based on demographic, economic and other characteristics. For example, areas with high population densities or areas with high-risk health characteristics such as high incidence of TB, may need to be treated differently.

Policymakers must be empowered down to the district and local levels to respond differentially based on local data and ground realities. These ground realities then translate into differential and graded decisions on smart testing strategies, physical distancing and lockdown measures, relief measures, public messaging, health sector capacity, and so on.

The active learning aspect calls for re-evaluating policy measures regularly based on data and evidence. This will help us better understand the benefits and costs of each policy and refine accordingly. This process of continuous re-evaluation can provide a roadmap for the next 18 months that is fully guided by the evidence.

The roadmap should inform the design of physical distancing measures and enable better targeting of support measures to rebuild the economy and society.

Consider the two contrasting policy choices (a) a weaker lockdown where there is isolation, contact tracing and care for those who are sick but there is also a degree of freedom of movement to allow essential workers, such as food producers and distributors, to continue their work, or (b) strict quarantines and physical isolation which will require massive investments in maintaining food chains, ensuring necessities for every family and providing critical care for those who need it.

Up till now, decisions have been made in the face of substantial uncertainty without any clear guidelines for how those decisions should be made to resolve the uncertainty as rapidly as possible. The approach we recommend incorporates prior information and multidisciplinary expertise in a structured fashion and enables real-time data responsiveness.

The Analytical Angle is a monthly column where top researchers bring rigorous evidence to policy debates in Pakistan. The series is a collaboration between the Centre for Economic Research in Pakistan and Dawn.com. The views expressed are the authors alone.

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The Analytical Angle: How smart containment, along with active learning, can help mitigate the Covid-19 crisis - DAWN.com

NASA’s incredible new moon map will serve as blueprint for human missions – CNET

The most comprehensive geologic map of the moon ever.

NASA is preparing for new missions to the moon, setting an ambitious goal for putting walkin', talkin' humans (including the first woman) back on the lunar surface by 2024. There's plenty of gigantic hurdles to overcome before that future is realized, but this stunning, detailed new map of the moon's surface features, produced by scientists from the United States Geological Survey (USGS), NASA and the Lunar Planetary Institute, is likely to play an invaluable role in fulfilling the agency's goal.

Known as the "Unified Geologic Map of the Moon", the cartograph looks like a rainbow Gobstopper and charts decades of geological surveys of the lunar surface, dating as far back as the Apollo era -- when humans first stepped foot on our celestial neighbor. Using regional maps from six Apollo missions combined with new data acquired by NASA's lunar orbiter and observations by Kaguya, a probe launched by the Japanese space agency which imaged the moon between 2007 and 2009.

Stay in the know. Get the latest tech stories from CNET News every weekday.

The colourful 1:5,000,000-scale geologic map, which was set to be unveiled during the 51st Lunar and Planetary Science Conference, is designed to serve as a resource for research and analysis efforts and to help future geologic surveys.

"It's wonderful to see USGS create a resource that can help NASA with their planning for future missions," said Jim Reilly, USGS director, in a press release.

The moon's pockmarked surface acts like a record of its history and the new map distinguishes between different geologic formations and time periods, using striking color to record the moon's past. The map is dominated by the pinks of the Imbrian era, which occurred some 3.5 billion years ago. During that time, the moon was smashed by asteroids, creating many of the impact craters we can see on the surface today.

A full-size version of the map can be found here.

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NASA's incredible new moon map will serve as blueprint for human missions - CNET

NASA astronauts on ISS tell John Krasinski that Earth is still beautiful – CNET

Nick and Joe Jonas are at your 2020 prom.

John Krasinskiwent above and beyond on the latest episode ofSome Good News-- to space. Astronauts on the International Space Station flashed a floating SGN banner with a background noZoomconference could ever top: the colossal curve of the Earth, shrouded in cloud.

NASA tweeted out a clip of the episode on Tuesday, saying "Yes, @JohnKrasinski -- that just happened!"

In the clip, the NASA astronauts say our planet is beautiful and that even an Earth in crisis is still worth returning to. NASA astronauts Jessica Meir and Drew Morgan, along with Russian cosmonaut Oleg Skripochka, returned to Earth on April 17.

Krasinski has also been touting a virtual prom for high schoolers holed up at home, and during episode 4 on Sunday, he delivered. Balloons, streamers, full-on DJ set and, yes,the Jonas Brothers in tow, Krasinski put on a show to rival every teen movie. (Jump to 12:33.)

The YouTube show, created to shine a light on all the ways people are helping and entertaining each other in this time of lockdown, has a reputation for the spectacular, from celebrity cameos to grand gestures for those deserving.

As for celebrity cameos, Brad Pitt replaced Robert De Niro as SGN's weather reporter. Yes, you read that right. (Jump to 6:55.)

Krasinski then proceeded to throw the biggest names together in organizing a virtual prom for the class of 2020. He consulted ex-The Office costar Rainn Wilson, Chance the Rapper and the Jonas Brothers, who performed Sucker via Zoom for those dressed up in their bedrooms.

And then the capper: Billie Eilish and her brother and songwriting partner Finneas O'Connell dropped by to perform Bad Guy. Class of 2020, hope you enjoyed virtual prom.

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NASA astronauts on ISS tell John Krasinski that Earth is still beautiful - CNET

OSU Receives NASA Award to Study Weather for Drones – AviationPros.com

NASA awarded a team of Oklahoma State University researchers $5.2 million over the next four years to study low-level wind and turbulence forecasting.

The research aims to improve the safe operation of drones in both urban and rural environments, particularly in the field of advanced air mobility that could one day include autonomous transport of people and cargo.

NASA's University Leadership Initiative Award totals $32.8 million and will also go to teams at Stanford University, the University of Delaware, North Carolina A&T State University and the University of South Carolina.

Each of these teams is working on important problems that definitely will help break down barriers in ways that will benefit the U.S. aviation industry, said John Cavolowsky, director of NASAs Transformative Aeronautics Concepts Program in Washington, D.C.

OSU investigators include professors Jamey Jacob, Brian Elbing, Imraan Faruque and Nicoletta Fala. Jacob, the director of OSUs Unmanned Systems Research Institute, is the projects principal investigator. Researchers from the OSU institute have worked with NASA in the past.

Selection to the NASA University Leadership Program confirms OSUs expertise and preeminence in unmanned systems, particularly in the area of unmanned aircraft for weather and meteorological applications, Jacob said.

NASA hopes the University Leadership Initiative will unite its Aeronautics Research Mission Directorate and prominent American research universities to produce new, innovative ideas. Jacob said the NASA University Leadership Initiative program allows university and industry teams to provide unique solutions to the most complex problems facing aeronautics today.

"The challenge our team is addressing will have an impact across a wide range of aircraft, not only helping advance the integration of drones and urban air taxis into the national airspace, but also increasing the safety of air transportation and airport operations for all aircraft from airliners and general aviation aircraft alike, he said.

OSUs team includes members from Oklahoma State University, the University of Oklahoma, the University of Nebraska, the University of Kentucky, Virginia Tech University, the National Center for Atmospheric Research, Vigilant Aerospace Systems Inc. AirXOS and the Choctaw Nation of Oklahoma.

2020 The Oklahoman

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NASAs new rover is headed to the perfect spot to hunt for life on Mars – BGR

NASAs Mars 2020 mission launch date is rapidly approaching, and weve seen all the signs that the Perseverance rover is just about ready to make the long journey to the Red Planet. What will it find when it arrives? Thats a question nobody can answer, but new research by scientists at Stanford suggests that the rovers targeted landing site may be a great place to look for signs of life.

NASA chose the rovers landing location a large bowl-shaped depression known as the Jezero crater because its located in an area where ancient martian rivers flowed, carving channels and depositing sediment into layers. This is ideal for scientists hunting for signatures of life as it offers the opportunity to study material that was on the surface over a long period of time.

Stanford scientists used aerial images of the Jezero crater and the surrounding area to build a model of how the area developed. They found that the sediments deposited near the dried-up river delta have a high probability of preserving signs of ancient life, if it did indeed exist.

There probably was water for a significant duration on Mars and that environment was most certainly habitable, even if it may have been arid, lead author Mathieu Laptre said in a statement. We showed that sediments were deposited rapidly and that if there were organics, they would have been buried rapidly, which means that they would likely have been preserved and protected.

Thats incredibly important, as exposure on the surface could have easily destroyed evidence of life before it had a chance to be covered in layers of sediment and preserved. The sediment layers are believed to have formed rapidly, but only when specific conditions were present on the surface. The active formation of the river delta may have only taken 20 to 40 years, but that formation was likely discontinuous and spread out across about 400,000 years, according to the scientists.

People have been thinking more and more about the fact that flows on Mars probably were not continuous and that there have been times when you had flows and other times when you had dry spells, Laptre explains. This is a novel way of putting quantitative constraints on how frequently flows probably happened on Mars.

The Mars 2020 mission is slated to launch in late July or early August of this year. The timeline is tight, and NASA cant afford to miss the launch window. If for some reason the launch is delayed beyond the early August limit, the entire mission would have to be pushed back to 2022 at the earliest due to the nature of the orbits of Mars and Earth.

Image Source: NASA/JPL-Caltech/ASU

Mike Wehner has reported on technology and video games for the past decade, covering breaking news and trends in VR, wearables, smartphones, and future tech. Most recently, Mike served as Tech Editor at The Daily Dot, and has been featured in USA Today, Time.com, and countless other web and print outlets. His love ofreporting is second only to his gaming addiction.

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NASAs new rover is headed to the perfect spot to hunt for life on Mars - BGR

Ariana Grande Had the Best Reaction to Chrissy Teigen’s Daughter Luna Singing ‘NASA’ – ELLE.com

Chrissy Teigen's four year old daughter Luna got a karaoke machine, so her mother shared footage of her singing Selena Gomez's "Hands to Myself" and Ariana Grande's "NASA" on her Instagram Story. The clips were cuteand got Grande's attention. (Having a famous mom with a huge following and tagging Grande can really make things happen.)

Grande's reaction to Luna singing her song ended up being what most fans dream of: Grande watched and featured Luna's cover in her Instagram Story. Grande captioned the clip with an emotional emoji and white heart.

Grande's shoutout comes about a week after Luna celebrated her fourth birthday in quarantine with her mother, dad John Legend, and little brother Miles. Legend revealed on his Instagram that Teigen went out of her way to make Luna's day special by decorating the house and making sure there was plenty of cake.

"Luna's living her best birthday life," he wrote. "Mommy decorated. No preschool friends were able to come, but they sent video messages and she was thrilled. Good memories for her during this strange time."

Teigen and Legend both shared Instagram birthday tributes to their daughter ahead of the day's celebrations. "happy 4th birthday to the queen of our household," Teigen captioned hers. "I could have never prayed for a better little being."

"Happy 4th birthday to our beautiful Luna!" Legend wrote in his post, which featured a gallery of photos taken throughout her life. "I'm so happy I get to be your father, teacher, friend. "

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NASA Tracker Detects Massive Asteroid Passing By Earth On Sunday – International Business Times

KEY POINTS

NASA is currently tracking a massive building-sized asteroid thats expected to approach Earth on Sunday (April 26). Aside from the incoming asteroid, two other near-Earth objects will fly past the planet this weekend.

According to NASAs Center for Near-Earth Object Studies (CNEOS), the massive asteroid has been identified as 2020 FM6. It has an estimated diameter of 820 feet and is currently moving towards Earth at a speed of almost 38,000 miles per hour.

Given its massive size and speed, the asteroid is capable of causing a major impact event on Earth if it hits the planet. Due to this, 2020 FM6 has been classified by NASA as a potentially hazardous asteroid.

Potentially hazardous asteroids are currently defined based on parameters that measure the asteroids potential to make threatening close approaches to the Earth, NASA explained. Specifically, all asteroids with a minimum orbit intersection distance of 0.05 [astronomical units] or less and an absolute magnitude of 22.0 or less are considered [potentially hazardous asteroids].

According to CNEOS, 2020 FM6 is expected to approach Earth on April 26 at 11:35 p.m. EDT. During its approach, it will be about 0.03673 astronomical units or 3.4 million miles from the planets center.

Aside from 2020 FM6, Earth will also be visited by two other asteroids on Sunday. The first one is called 2019 HS2. CNEOS noted that this asteroid measures about 92 feet wide and is approaching Earth with a velocity of 28,000 miles per hour.

The second asteroid that will arrive on Sunday is known as 2019 GF1. This asteroid is currently traveling across space at a speed of 7,000 miles per hour. It has an estimated diameter of about 65 feet.

According to CNEOS, both asteroids belong to the family of Aten space rocks. This means that 2019 HS2 and 2019 GF1 follow natural orbits that intersect Earths path.

2019 HS2 will fly past Earth on April 26 at 10:40 a.m. EDT from a distance of 0.03488 astronomical units or roughly 3.2 million miles away.

2019 GF1, on the other hand, will approach the planet on April 26 at 7:55 p.m. EDT from about 0.04783 astronomical units or 4.4 million miles away.

Over 17,000 near-Earth asteroids remain undetected in our solar neighborhood. Pictured; an artistic illustration of an asteroid flying by Earth. Photo: NASA

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Politics behind the pandemic – WAOW

Wisconsin (WQOW) -Tension appears to be growing between Democrats and Republicans as state GOP leaders move forward with their suit to stop the Safer-at-Home extension, and hundreds of Wisconsinites continue to protest the order.

From fear to fury, Wisconsin residents are torn over whether the state economy should re-open. With both sides of the political aisle seemingly going head-to-head, one political science expert said this behavior is not unexpected.

"If you look at most other democracies in the world, you don't see this happening," said Geoffrey Peterson, the UWEC political science head. "You tend to see the parties actually coming together to try and address what's happening. I also think, honestly, this is just a reflection of the nature of American politics."

Because COVID-19 has become a partisan issue, Peterson said it makes sense that voters are now reacting through public displays such as protests.

"I think if you had a situation where both parties came together on major issues, I think you'd see a lot of this tension disappear," Peterson said. "But the fact that the parties have chosen to kind of stake out positions on this and turn this into an argument, then not surprisingly voters do the same thing because they're following the leadership of their party."

One of the largest demonstrations of political divide amid COVID-19 is the recent decision of state Republican leaders to file suit against Andrea Palm, the secretary of the Wisconsin Department of Health Services for the Safer-at-Home extension.

"Basically, they're saying to the Supreme Court, 'she didn't follow the rules. The rules were broken. So we should then be able to stop this because it's an illegal order,'" attorney Harry Hertel explained, emphasizing the legality in question is centered around authoritative power.

"So she's basically utilized emergency powers. The question being: was there a procedure she didn't take? Was there a requirement of a time frame she didn't follow? Was this beyond the scope of the authority she had either directly from the statutes, or in the alternative an extension of the power of the executive branch to take action?" Hertel said.

As Wisconsin awaits a ruling, Peterson said one thing is certain when it comes to American politics during a pandemic.

"Is a pandemic truly a political issue? Probably not, but in The United States everything is a political issue right now," Peterson said.

As for the upcoming 2020 presidential election, Peterson said it's possible some Wisconsinites will sway their votes based on how President Trump and former Vice President Biden continue to handle this pandemic.

Peterson also said that as more uncertainty surrounds the pandemic, it's difficult to predict much with this year's campaigns.

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Politics behind the pandemic - WAOW

Maryann Plunkett, Liza Jessie Peterson and More to Appear on 10PM WITH GALINSKY – Broadway World

10 PM With Galinsky is a new, thirty-minute talk-variety show that stars performer, artist, activist Robert Galinsky streaming live each night from his Alphabet City NYC studio. Galinsky interviews celebrities, newsmakers, and exceptional people doing extraordinary things. The casual conversation format features guest photographs and audience participation through live chat.

10 PM with Galinsky, streams live, Monday -Friday at 10 PM on Facebook.com/RobertGalinsky.

This week's guests include:

Clayton Patterson is a Lower East Side outlaw artist, rebel, photographer, infamous documentarist of riots, anarchists, squatters, graffiti and tattoo artists, skaters, poets, punks, leathered rock'n'rollers, skinheads, Santeria priests and the ignored, abused, and broken.

Liza Jessie Peterson is a Drama Desk Award Nominee, Agnes Gund's prestigious Art for Justice Fund recipient, featured in Ava DuVernay's, "The 13th", consultant on Bill Moyer's doc, "Rikers", critically acclaimed performer and writer of the one woman show "The Peculiar Patriot".

Coach Frank "Buddy" Leonard is a special Assignment Scout for the New England Patriots (Super Bowl winning season), tight ends coach St. Louis Rams, assistant head coach, tight ends Coach Boston College, 36 years in college/pro coaching, super soulful recruiter and mentor.

Maryann Plunkett is a Tony Award winner for Broadway's Me and My Girl. Also featured/starring roles in film & TV: Brooklyn Lobster, Little Women,House of Cards, The Gabriels, MAD, Manifest, The Good Wife, Blue Valentine, The Squid and the Whale and much more

Robert Galinsky Solo - A mix of best moments from the past week's guests, improvisations with chatters, readings of new scripts and more variety

Past guest have included: Jay O. Sanders (JFK, Day After Tomorrow). Lin Shaye (Penny Dreadful, Insidious, Something About Mary), Billy Hayes (Midnight Express), Richard Stratton (Writer/ Producer), Keith Shocklee (founding member of "Public Enemy), Chad Morgan (Actor and Voiceover Artist).

Robert Galinsky is a performance and media coach whose clients include 50 Cent (Rapper/Actor), Libby Moore (Oprah Winfrey's Chief of Staff), Kofi Appenteng (President Africa-America Institute, Board, Ford Foundation), Ariel Barbouth (Founder, CEO Nuchas Empanadas) and many more. He has coached clients for appearances on Shark Tank, The View, ABC Nightline News, the Today Show and multiple presentations at the United Nations. Galinsky was head speaker coach for TEDx Teen for 10 years, from its inception, and his work as a coach and producer has taken him around the globe to such places as India, the United Kingdom, Canada and South America.

Photo Credit: Walter McBride / WM Photos

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Maryann Plunkett, Liza Jessie Peterson and More to Appear on 10PM WITH GALINSKY - Broadway World

Iowa State starts re-stocking what could be a depleted tight end position with immediately eligible transfer – Des Moines Register

Iowa State football coach Matt Campbell has high hopes for Brock Purdy, Breece Hall and Charlie Kolar Des Moines Register

Iowa State added a tight end to its 2020 recruiting class. The significance of this, however, isn't what can happen this season. It's about going forward the Cyclones fortifying the future of what's become a significant position again.

DeShawn Hanika, a 6-foot-6, 225-pounder from Butler Community College, committed to Matt Campbells program Wednesday via social media.

They like the fact that I can put my hand down in the ground, or they can split me out wide for mismatches, Hanika told 247sports.com. They just talked about how they use the tight end so much in the pass gameand they thought Id be an ideal fit for their offense.

Butler Community College tight end DeShawn Hanika commits to Iowa State's 2020 recruiting class(Photo: Butler Community College)

Hanikaredshirted last season at Butler, which means he has four seasons of eligibility remaining for Iowa State.

Thats a good move for Campbell's program, whichloses senior tight endsChase Allen and Dylan Soehner after the 2020 season. Theres also a chance that redshirt junior Charlie Kolar, Iowa States No. 1 tight end, could enter the 2021 draft.

Campbell said Iowa Staterequested feedback from the NFL College Advisory Committee on the talented Kolar last year.

Charlie and his family really have to take some of that information it just got back the last couple days ... but I think Charlie knows kind of where hes at, and certainly where he needs to continue to go as well, Campbell said shortly after arriving in Orlando for last season's Camping World Bowl game.

Iowa State head football coach Matt Campbell celebrates with defensive end Will McDonald after McDonald sacked Kansas quarterback Carter Stanley in the second quarter on Saturday, Nov. 23, 2019, at Jack Trice Stadium in Ames.(Photo: Bryon Houlgrave/The Register)

Shortly after the loss against Notre Dame, Kolar wrote on Twitter:

To our seniors, thank you. I will cherish the memories I have with every single one of you. To our fans I apologize. You all deserve better. Im not going anywhere theres too much left to be done."

The All-American caught51 passes for 697 yards and seven touchdowns last season.

Hanika had offers from Louisiana Tech and Florida Atlantic, but was garnering interest from Michigan State, Oklahoma State and TCU, according to 247sports.

Then Thursday, Campbells ambitious April on the recruiting trail continued when linebacker Myles Mendeszoon, of Chardon, Ohio committed to the Cyclones on social media.

Im very honored to say I will be continuing my academic and football career at Iowa State, Mendeszoon wrote on Twitter. Im very grateful and honored to call myself a Cyclone.

The 6-foot-4, 195-pounder who also plays defensive end, is the 10th high school recruit for the 2021 class. Hes the fifth 2021 recruitment this month.

Iowa State columnist Randy Peterson has been writingfor the Des Moines Register for parts of sixdecades. Reach him at rpeterson@dmreg.com, 515-284-8132, and on Twitter at @RandyPete. No one covers the Cyclones like the Register. Subscribe today at DesMoinesRegister.com/Deal to make sure you never miss a moment.

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Iowa State starts re-stocking what could be a depleted tight end position with immediately eligible transfer - Des Moines Register

‘The Last Kids on Earth’: Max Brallier and Scott Peterson on Season 2 and Beyond – Collider.com

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From New York Times bestselling author Max Brallier and showrunner Scott Peterson of Atomic Cartoons comes the fun and lighthearted animated series, The Last Kids on Earth. The Netflix hit follows Jack Sullivan (Nick Wolfhard) and a band of suburban middle-schoolers living in a decked-out tree house, playing video games, gorging themselves on candy, and battling zombies. 10 all-new episodes arrived on Netflix today; be sure to add them to your watchlist now!

In honor of the new seasons arrival, I had a chance to chat with Brallier and Peterson as part of our continuing Saturday Mourning Cartoons interview series, like our related chat with Wolfhard himself. I checked in with the EPs after our previous chat, which came before the launch of The Last Kids on Earth. We talked about how the creative team is dealing with the current quarantine situation and whether or not that affected their writing process for the post-apocalyptic series. Brallier and Peterson also talked about how much the cast of characters has grown in Season 2, both in maturity and by including new voices actors, like Mark Hamill, Rosario Dawson, Catherine OHara, Bruce Campbell, and Keith David; all of their antics and more are teased in the following interview. Feel free to listen and read along, but some spoilers follow for this season!

Image via Penguin Young Readers Group

This is the second time that Ive had a chance to talk with you both, but the last time we talked, it was before Season 1 had even launched. So how has the response been since last fall?

Scott Peterson: Well, we dont get numbers from Netflix. They keep those very close to the chest. But what we understand is that its done really, really well, that its exceeded their expectations in terms of how many people have been watching it, and thats just for the first 66-minute special that was based on Book One. But anecdotally, weve heard lots of people love it, kids watching it over and over again. So were really pleased.

Max Brallier: Ive been extremely pleased, Ive been just doing school visits and things like that since the series has launched, that fans of the books have really been fans of the show and have had really wonderful, great, enthusiastic, happy things to say, which was the thing that I most hoped would come true.

So how are you guys both feeling now that Season 2 is actually here for fans out there to enjoy?

Max Brallier: I feel great. Im really happy that its been Yeah, that its actually finally here, the fans can enjoy it. Im kind of excited for fans of the book series to see whats different, whats changed, and what sort of Easter eggs we have in there for them. Atomic Cartoons, everybody there has done a wonderful job creating this new season, and really Scott in leading the show.

Scott Peterson: Yeah, its a phenomenal season, and whereas the special really kind of sets up the world and the characters, this is where we get to just go crazy and really expand on all that, and bring in a whole new host of characters, and really send the kids on much bigger adventures, all based on Maxs books. But it really gives us an opportunity to go much, much bigger, which I think kids are going to really love.

Where does Season 2 line up with the timeline of the books, and where does it deviate? Is it mostly Zombie Parade, or is there a little bit of extra thrown in?

Image via Netflix

Max Brallier: Its mostly Zombie Parade, but taking advantage of our ability to tell the story now not just from Jacks point of view, but to see what other characters are doing. New adventures, sort of adding, changing, adjusting, and really just sort of taking the best parts of Zombie Parade and really kind of trying to make those as big and amazing as possible, and then also trying to find places to create new adventures that will excite and I mean, its not a straight adaptation where youll feel like, Oh, if I read the book, I already know exactly whats going to happen. There are some big moments that play out differently and play out, I think, just really in wonderful visual ways.

Scott Peterson: One good example of that is theres an episode called June Gloom, where Jack takes June back to her childhood home, thinking this is going to be a wonderful treat for her, and not realizing there may be a lot of other emotions involved. Thats something that wasnt really in the book, but we felt like we really want to expand on what Junes going through, because thats something we have the time for and, again, that we didnt get a chance to do in the books. Its turned out to be one of my favorite episodes, because we really get into the emotions of the kids beyond the excitement of battling monsters and zombies. Written by the marvelous Haley Mancini.

Scott Peterson: Yes.

I love the maturity that comes with Season 2. How do you think that Jack and the kids have grown, if at all, between the end of Season 1 and Season 2 where things pick up?

Max Brallier: Hes two inches taller.

Image via Netflix, Atomic Cartoons

Scott Peterson: I think for Jack in the opening book and the opening special, he was just learning to form a family, and now hes got to learn what its like to actually have a family, and what its like to live with other people, and what its like to fear losing people or Theres a lot that hes never experienced before. So I think for him particularly, this is a big season of learning about how to deal with other people that you care about.

Max Brallier: Yeah, and how to sort of be a hero and be a leader, but at the same time, not just try to keep everybody safe all the time. How to let people sort of be their own people. And be their own monsters.

How have you seen Jack grow since the beginning, and what can viewers expect to see from him as he grows as a person over the course of Season 2?

Max Brallier: I think a little bit, too, what Scott was saying about going from really wanting a family to now also wanting a community, and that sense of the camaraderie, and now having that. But with that comes this incredible fear of losing that. I think thats something that its sort of about. I remember kind of finding my people, finding your clique in elementary school and middle school, just finding a group of friends, and that theres suddenly Once you do that, there is that sense of, Oh boy, what if this goes away? What if something happens? Thats sort of whats happening here, but on a monstrous, ginormous stage full of action-adventure. So we see him sort of come to terms with that and learn how to live with that and deal with that.

Then also at the same time, were setting up sort of the larger heros journey, where its not just about the friendship stuff and the personal stuff, but how he learns to lead as the world continues to grow. Sort of this world continues to grow and the threat becomes not just a threat to his hometown, but its a interdimensional threat from beyond that. Huge. How will he lead in that world?

Image via Netflix

Scott Peterson: I think whats fun is that sometimes we can take something thats relatable, like losing your friends, but in real life, youd be worried about losing your friends to another group of friends, or maybe theyd move away. In this world, Jacks worried hes going to lose his friends because they might be eaten. So it really amps up whats a normal feeling to a huge degree.

One of his big arcs for this season is he gets so worried about them that he becomes overprotective, and so he doesnt want them to leave the house. He doesnt want them to take any risks. And he becomes kind of a jerk. Its out of how much he loves them and cares for them, but he becomes so overbearing that he has to find a way to let them be their own heroes.

Jack is definitely not your traditional expected hero. He struggles a lot with the choices that he makes and learning from his mistakes over and over again. How do you both see Jack, as hes growing?

Max Brallier: I think hes flawed. Hes certainly not perfect. Its been a fun and exciting and sort of the unexpected thing about writing this series, and really the book series as Im looking at it is a larger growth for him over seven books right now, that there continue to be things that sort of surprise me about the character. I usually say, I feel like, Im the one writing the character. None my characters surprise me, I usually feel like that. But there are moments where I sort of feel like, Oh, wait. This is really going to challenge his view of things, or his view of other people, or of monsters, or of how to be a leader and how to have friends and all these things.

I think for me, the challenge and the fun of it is how to make Jack be somebody who fails, and who fails on a personal level, too, and who fails his friends at times, and is sarcastic and handles things with humor and sarcasm, without him ever becoming unlikable or anything like that. Its a balance between I dont want him to be perfect, and I dont want him to be somebody who you dont like. Its this sort of mixture of seeing his flaws and loving him for the flaws. Thats how I try to make it work.

Image via Netflix, Atomic Cartoons

Scott Peterson: Yeah, I think its a lot more interesting to follow someone that you can relate to, knowing that sometimes they win and sometimes they fail, as opposed to reading Superman comics as a child. Hes always going to win, so theres not Hes almost invulnerable, so theres not a lot of stakes there. But if you have a kid whos like our readers or like our viewers, that doesnt always know what theyre doing and has to make the best with what theyve got, thats much more compelling.

Definitely. Then looking outside of kind of the core cast of characters that we have, you guys get to expand the cast quite a bit in Season 2. Weve got Keith David, Mark Hamill, Catherine OHara, Rosario Dawson. They get to join in on the fun this season. What can you tease about the new actors that youve brought in and their roles in Season 2?

Scott Peterson: And dont forget Bruce Campbell.

Oh, of course! How could I?

Scott Peterson: We worked hard to get him on the show.

Yeah, and hes got a great part, too. Its so much fun.

Scott Peterson: Unfortunately, we cant talk about their roles yet. Weve been forbidden from the powers that be. So even though you know because youve watched the episodes, we cant tell people just yet.

Max Brallier: I will say that they all do amazing jobs, and that they bring characters to life in an incredible way.

Image via Netflix

Scott Peterson: And they were phenomenal to work with. I mean, we were basically sitting there with our mouths open as were looking 10 feet away at Mark Hamill in the recording booth, and hes telling us stories about Star Wars, unprompted. We werent digging. We were trying to be professional. But he started telling us things, and were just like Were eating it up like 12-year-olds. It was amazing.

Yeah, Im sure he knew what you wanted to hear anyway. Hes like, You guys want to know these stories. Youre just being polite and not asking, so Ill give you one. Yeah.

Scott Peterson: Yes. Yes, it was great. And the same thing with Bruce that were all huge fans of Evil Dead, and to be in a room with him and have him talking to us like we were real humans was amazing.

Max Brallier: Yeah. We fooled him.

Can talk about adapting the characters from the stories for the animated version? Were there any significant changes? What were your discussions like in bringing these characters to live in a way that fits with the art style and the aesthetics of the animated series?

Scott Peterson: Yeah, we couldnt always do exactly what was in the books. Doug Holgate did an amazing job bringing these characters to life visually for the first time, but sometimes you cant do that level of detail in an animated series. And sometimes we wanted to do something a little bit different. So a lot of kind of the background character monsters, we came up with our own and created new characters for that.

But for some of the iconic ones, like theres a character called Bardle, and theres a character Skaelka, and Thrull, we did try to emulate what Doug had done in the books, but again, bring them into our world. Then we get a chance to expand their characters, particularly Skaelka. She has a smaller role in the books to begin with, but we found her so much fun that we really expanded her role and put her in a lot more episodes, gave her more to do, because she was so fun.

Image via Netflix

Max Brallier: Yeah, and then for Bardle, who becomes sort of a mentor to Jack in the books, we had a lot of fun There was times to sort of make him a much Do more humor and really bring out the humor in him, and find ways to sort of take his sort of stiff demeanor and play that for comedy when appropriate. That was a lot of fun.

Is there anywhere that I can get a copy of The Last Kids on Earth bestiary? Is that something thats going to be available for people out there? Or do I have to make my own, like Quint?

Max Brallier: Oh, yes. Oh, so lets see. For the ones from the book, we have a Jack calls the bestiary a beast-iary, because its full of beasts. In The Last Kids on Earth Survival Guide that I wrote, we have a sort of partial version that has a bunch of the monsters from the books and shows off sort of details Like those little Marvel cards that would have their stats and data on the back, and I loved those. So it does some of that stuff in the bestiary, in the book. We need to create a full one for the series monsters, I think, though.

Scott Peterson: Yeah, that was a great I mean, if I was a kid, I would absolutely want that. But yeah, one for the show. Because it does differ from the books, especially, yeah, when we get into all the ancillary monsters. Or we created a new character, Chef, for the series, because we wanted someone to kind of battle back and forth with Dirk. We wanted a monster that He isnt really thrilled to be around these humans, and to see how that played out. So we created this character thats really kind of prejudiced against humans to see how that played out, and that was really fun.

Max Brallier: Yeah, and he thinks the humans smell.

Scott Peterson: Yeah.

Which, hes not wrong.

Scott Peterson: Well, we do.

Yeah.

Max Brallier: We do.

Image via Netflix, Atomic Cartoons

Well, as a grown-up kid myself, I would be happy with the Quint-essential Bestiary Guide to Last Kids on Earth, so feel free to run with that if youd like to. Id be happy to pick that up.

Pulling back from the fictional apocalypse for a bit, I think Id be remiss if I didnt mention that were currently living in some sort of weird, uncertain, and unpredictable time. So what is it like for the two of you to be writing a show about an apocalypse while also having to balance living through sort of one?

Max Brallier: I havent checked the news recently. What is it youre referring to?

Yeah, really.

Max Brallier: Not a news junkie.

Scott Peterson: Hes unaware. I think whats interesting is Max is in New York, and Im in L.A., and weve both kind of been working from home for a long time. But all the animators and all the production crew up in Canada have just been sent home the last few weeks, so theyre now all working from home. So its really a challenge to try and keep in touch with everybody and maintain those personal connections, even when everybodys separate. But in terms of storytelling, were not writing any episodes right now that would then change because of our personal experiences. Its just kind of a unique time to be in.

I think one thing that weve always wanted the series to talk about is making the best of a bad situation, that Jacks goal is not just to live through the apocalypse, its to thrive in it and to have fun in it. He sometimes calls it the funpocalypse. So if we can send any message out right now, its to not just endure what were going through, but to try and make the best and do the best with what you have, and try and keep a positive attitude the way Jack would. Thats a message that we were sending out before this current situation, and I think that would be the message after this as well.

Image via Netflix, Atomic Cartoons

Max Brallier: Yeah, I dont think the message changes. In the end, its a show that, despite the setting, its about bonds, and friendship, and hope, and positivity, and adventure, and the exciting sort of pulse, but just the excitement of adventure and friendship and doing that together. So that doesnt change, but it feels sort of almost extra applicable right now.

Its also about escapism, and I think sometimes I dont know. Thats an important thing. Thats always an important thing, I think, especially for kids, that you need to sort of get away for a little bit and forget about a bad day at school or whatever it is. Here, I think we may need that more than ever. I hope that maybe it allows people to escape a little bit for a couple hours. Thatd be neat.

There are some subtle things that are brought up throughout this season between some of the characters. They open up a little bit more, they talk about their past a little bit more. Some of them get to revisit that past through memories or flashbacks. Are you hoping that maybe this opens up a dialogue for kids who dont quite know how to talk about bad feelings, or bad memories, or things like that?

Scott Peterson: I dont think we ever had an agenda about getting kids to open up. But if they can see themselves in these characters and see that it helps people to grow closer together by being open with each other, thats a fantastic byproduct. We always wanted these characters to feel realistic and not like 2D cartoon characters. So yeah, that would be fantastic.

Max Brallier: Yeah, I think theres something about sort of the end-of-the-world setting and the things that happen to them that causes them to open up in a way that Its almost like the Breakfast Club, where they sort of are all stuck there together and for the first time, they see each other as real people in the Breakfast Club. Here, it causes June to talk about things to Jack that she never would have. If thats a lesson you can learn earlier on in life, thats good. I think that sort of the younger that you are able to understandit took me a long time, that its okay to tell people how you feelthe better. So if people get help with that from this at an earlier age, I think that would be wonderful.

Do you have a favorite newcomer character this season? Do you have a favorite episode that stands out to you that you just want to highlight?

Max Brallier: I was going to say I think we both were going to say, I had mentioned June Gloom. I think that was one of my favorites from this season, just because for how the way it balances I think it achieves sort of what the show and what the series is, what it does very best, which is balancing humor with adventure with real emotion and action. So thats probably my favorite episode of this season.

There is a character that we created, though, for the show that I loved so much that the character was then pulled into the books.

Oh, cool.

Max Brallier: So that character I particularly love.

Nice. Scott, any for you that you can talk about?

Scott Peterson: I was going to say the same episode, but now I cant do that.

Yeah. Its a good episode.

Scott Peterson: I mean, Im also a sucker for the big ending, so the last episode is called Dawn of Rezzoch. We really have some amazing animators that can take things that we think up and bring them to amazing life. Watching huge monster battles and big finale action sequences, they really kicked some serious butt. I get caught up in those every time.

It was spectacular. I remember talking with you guys about Season 1 as well, and one of the highlights was that big battle at the end of Season 1. This takes it up to quite a different level on a number of ways. So yeah, definitely something to look forward to out there.

I cant wait for people out there to check out Season 2. As a side note, as someone who grew up eating at Joes Pizza once a week in my hometown, this season, that moment was particularly enjoyable for me, so thank you for including my hometown pizza shop. Loved that.

Max Brallier: I did that for you.

Thank you so much.

Max Brallier: I knew that you went there.

Exactly.

Max Brallier: Thats why we did it, yeah.

I really do appreciate that. But I appreciate your time today. Best of luck with the rollout of Season 2, and thanks again.

Max Brallier: Thanks so much.

Scott Peterson: Thank you, and be safe, be healthy. All that stuff.

Same to you.

All Episodes of Atomic Cartoons The Last Kids on Earth are now streaming on Netflix!

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'The Last Kids on Earth': Max Brallier and Scott Peterson on Season 2 and Beyond - Collider.com

What Is Darwinism? – ThoughtCo

Charles Darwin is known as the "Father of Evolution" for being the first person to publish his theory not only describing that evolution was a change in species over time but also put together a mechanism for how it works (called natural selection). There is arguably no other evolutionary scholar as well known and revered as Darwin. In fact, the term "Darwinism" has come to be synonymous with the Theory of Evolution, but what really is meant when people say the word Darwinism? And more importantly, what does Darwinism NOT mean?

Darwinism, when it was first put into the lexicon by Thomas Huxley in 1860, was only meant to describe the belief that species change over time. In the most basic of terms, Darwinism became synonymous with Charles Darwin's explanation of evolution and, to an extent, his description of natural selection. These ideas, first published in his arguably most famous book On the Origin of Species, were direct and have stood the test of time. So, originally, Darwinism only included the fact that species change over time due to nature selecting the most favorable adaptations within the population. These individuals with better adaptations lived long enough to reproduce and pass those traits down to the next generation, ensuring the species' survival.

While many scholars insist this should be the extent of information that the word Darwinism should encompass, it has somewhat evolved itself over time as the Theory of Evolution itself also changed when more data and information became readily available. For instance, Darwin did not know anything about Genetics as it wasn't until after his death that Gregor Mendel did his work with his pea plants and published the data. Many other scientists proposed alternative mechanisms for evolution during a time which became known as neo-Darwinism. However, none of these mechanisms held up over time and Charles Darwin's original assertions were restored as the correct and leading Theory of Evolution. Now, the Modern Synthesis of the Evolutionary Theory is sometimes described using the term "Darwinism", but this is somewhat misleading since it includes not only Genetics but also other topics not explored by Darwin like microevolution via DNA mutations and other molecular biological tenets.

In the United States, Darwinism has taken on a different meaning to the general public. In fact, opponents to the Theory of Evolution have taken the term Darwinism and created a false definition of the word that brings up a negative connotation for many who hear it. The strict Creationists have taken the word hostage and created a new meaning which is often perpetuated by those in the media and others who do not truly understand the real meaning of the word. These anti-evolutionists have taken the word Darwinism to not only mean a change in species over time but have lumped in the origin of life along with it. Darwin did not assert any sort of hypothesis on how life on Earth began in any of his writings and only could describe what he had studied and had evidence to back up. Creationists and other anti-evolutionary parties either misunderstood the term Darwinism or purposefully hijacked it to make it more negative. The term has even been used to describe the origin of the universe by some extremists, which is way beyond the realm of anything Darwin would have made a conjecture on at any time in his life.

In other countries around the world, however, this false definition is not present. In fact, in the United Kingdom where Darwin did most of his work, it is a celebrated and understood term that is commonly used instead of the Theory of Evolution through Natural Selection. There is no ambiguity of the term there and it is used correctly by scientists, the media, and the general public every day.

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What Is Darwinism? - ThoughtCo

Diabetes reversed in mice with genetically edited stem cells derived from patients – Washington University School of Medicine in St. Louis

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CRISPR corrects genetic defect so cells can normalize blood sugar

Researchers at Washington University School of Medicine in St. Louis have transformed stem cells into insulin-producing cells. They used the CRISPR gene-editing tool to correct a defect that caused a form of diabetes, and implanted the cells into mice to reverse diabetes in the animals. Shown is a microscopic image of insulin-secreting beta cells (insulin is green) that were made from stem cells produced from the skin of a patient with Wolfram syndrome.

Using induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes called Wolfram syndrome, researchers transformed the human stem cells into insulin-producing cells and used the gene-editing tool CRISPR-Cas9 to correct a genetic defect that had caused the syndrome. They then implanted the cells into lab mice and cured the unrelenting diabetes in those mice.

The findings, from researchers at Washington University School of Medicine in St. Louis, suggest the CRISPR-Cas9 technique may hold promise as a treatment for diabetes, particularly the forms caused by a single gene mutation, and it also may be useful one day in some patients with the more common forms of diabetes, such as type 1 and type 2.

The study is published online April 22 in the journal Science Translational Medicine.

Patients with Wolfram syndrome develop diabetes during childhood or adolescence and quickly require insulin-replacement therapy, requiring insulin injections multiple times each day. Most go on to develop problems with vision and balance, as well as other issues, and in many patients, the syndrome contributes to an early death.

This is the first time CRISPR has been used to fix a patients diabetes-causing genetic defect and successfully reverse diabetes, said co-senior investigator Jeffrey R. Millman, PhD, an assistant professor of medicine and of biomedical engineering at Washington University. For this study, we used cells from a patient with Wolfram syndrome because, conceptually, we knew it would be easier to correct a defect caused by a single gene. But we see this as a stepping stone toward applying gene therapy to a broader population of patients with diabetes.

Wolfram syndrome is caused by mutations to a single gene, providing the researchers an opportunity to determine whether combining stem cell technology with CRISPR to correct the genetic error also might correct the diabetes caused by the mutation.

A few years ago, Millman and his colleagues discovered how to convert human stem cells into pancreatic beta cells. When such cells encounter blood sugar, they secrete insulin. Recently, those same researchers developed a new technique to more efficiently convert human stem cells into beta cells that are considerably better at controlling blood sugar.

In this study, they took the additional steps of deriving these cells from patients and using the CRISPR-Cas9 gene-editing tool on those cells to correct a mutation to the gene that causes Wolfram syndrome (WFS1). Then, the researchers compared the gene-edited cells to insulin-secreting beta cells from the same batch of stem cells that had not undergone editing with CRISPR.

In the test tube and in mice with a severe form of diabetes, the newly grown beta cells that were edited with CRISPR more efficiently secreted insulin in response to glucose. Diabetes disappeared quickly in mice with the CRISPR-edited cells implanted beneath the skin, and the animals blood sugar levels remained in normal range for the entire six months they were monitored. Animals receiving unedited beta cells remained diabetic. Their newly implanted beta cells could produce insulin, just not enough to reverse their diabetes.

We basically were able to use these cells to cure the problem, making normal beta cells by correcting this mutation, said co-senior investigator Fumihiko Urano, MD, PhD, the Samuel E. Schechter Professor of Medicine and a professor of pathology and immunology. Its a proof of concept demonstrating that correcting gene defects that cause or contribute to diabetes in this case, in the Wolfram syndrome gene we can make beta cells that more effectively control blood sugar. Its also possible that by correcting the genetic defects in these cells, we may correct other problems Wolfram syndrome patients experience, such as visual impairment and neurodegeneration.

In the future, using CRISPR to correct certain mutations in beta cells may help patients whose diabetes is the result of multiple genetic and environmental factors, such as type 1, caused by an autoimmune process that destroys beta cells, and type 2, which is closely linked to obesity and a systemic process called insulin resistance.

Were excited about the fact that we were able to combine these two technologies growing beta cells from induced pluripotent stem cells and using CRISPR to correct genetic defects, Millman said. In fact, we found that corrected beta cells were indistinguishable from beta cells made from the stem cells of healthy people without diabetes.

Moving forward, the process of making beta cells from stem cells should get easier, the researchers said. For example, the scientists have developed less intrusive methods, making induced pluripotent stem cells from blood and they are working on developing stem cells from urine samples.

In the future, Urano said, we may be able to take a few milliliters of urine from a patient, make stem cells that we then can grow into beta cells, correct mutations in those cells with CRISPR, transplant them back into the patient, and cure their diabetes in our clinic. Genetic testing in patients with diabetes will guide us to identify genes that should be corrected, which will lead to a personalized regenerative gene therapy.

Maxwell KG, Augsornworawat P, Velazco-Cruz L, Kim MH, Asada R, Hogrebe NJ, Morikawa S, Urano F, Millman JR. Gene-edited human stem cell-derived cells from a patient with monogenic diabetes reverse pre-existing diabetes in mice. Science Translational Medicine, published online April 22, 2020.

This work was supported by the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of General Medical Sciences, the National Cancer Institute and the National Center for Advancing Translational Sciences of the National Institutes of Health (NIH). Grant numbers R01 DK114233, DK112921, TR002065, TR002345, T32 DK108742, R25 GM103757, T32 DK007120, P30 DK020579, P30 CA91842, UL1 TR000448 and UL1 TR002345. Additional assistance was provided by the Washington University Genome Engineering and iPSC Center, the Washington University Diabetes Center, and the Washington University Institute of Clnical and Translational Science, with additional funding from the JDRF, the Washington University Center of Regenerative Medicine, startup funds from the Washington University School of Medicine Department of Medicine, the Unravel Wolfram Syndrome Fund, Silberman Fund, Stowe Fund, Ellie White Foundation for Rare Genetic Disorders, Eye Hope Foundation, Snow Foundation, Feiock Fund, Childrens Discovery Institute, Manpei Suzuki Diabetes Foundation, and a JSPS Overseas Research Fellowship.

Washington University School of Medicines 1,500 faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Childrens hospitals. The School of Medicine is a leader in medical research, teaching and patient care, ranking among the top 10 medical schools in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Childrens hospitals, the School of Medicine is linked to BJC HealthCare.

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Diabetes reversed in mice with genetically edited stem cells derived from patients - Washington University School of Medicine in St. Louis

Case Researchers Awarded $3.7 Million to Test Emerging SCD Gene… – Sickle Cell Anemia News

A team at the Case Western Reserve University has been awarded up to $3.7 million from the National Heart, Lung, and Blood Institute (NHLBI) to conduct early studies of emerging gene therapies for sickle cell disease (SCD).

Led by Umut Gurkan,PhD, the team will examine blood samples collected from SCD patients before and after they receive gene therapies, and test them for improvements in red blood cells.

These potential gene therapies work by modifying a patients own hematopoietic stem cells, which generate red and other blood cells. Then, the modified stem cells are given back to the patient via a bone marrow transplant, which overcomes the difficulty in finding matched donors in those with SCD.

Patients will receive the therapies over the next two years as part of clinical trials conducted at leading U.S research universities and hospitals, includingStanford University, the University of California San Francisco, Emory University, the University of North Carolina, and Albert Einstein College of Medicine.

The overall goal is to make genetic therapies for SCD available within five to 10 years.

The big-picture potential here is to test whether this is dream or reality when it comes to gene therapy curing sickle cell, Gurkan said in a press release. We dont know the answers yet, but we have to ask whether these gene therapies are safe and effective in alleviating the symptoms and curing the disease and if we have the right tools.

Due to a mutation in the HBBgene, red blood cells of SCD patients acquire an abnormal and more rigid shape, while also becoming stickier than normal. This contributes to the formation of clogs that prevent or slow blood flow in small vessels, depriving tissues of oxygen.

Using a kind of lab-on-a-chip approach, researchers essentially mirror the tiny capillaries of the human body, which allows them to investigate how red blood cells move in these engineered capillaries.

The Case team will investigate if the gene therapies improve blood flow and test for improvements in red blood cell stickiness, as well as density, and shape.

If a curative therapy is successful and effective, we should see a significant improvement in these vital properties of blood, Gurkan said. Essentially we would like to objectively and quantitatively assess how well the blood cells flow in tiny capillaries after a gene-based therapy.

According to Gurkan, Case University has been playing an important role in the development of these new blood tests, which could help identify patients who respond to a given therapy early on.

As the genetic cure for sickle cell becomes a clinical reality, longitudinal, simple and accurate assessment and control through the tests that Dr. Gurkan has developed becomes ideal and opens up this new treatment to patients across the world, said Stanton Gerson, MD, director of the Case Comprehensive Cancer Center.

Our team is committed to making these new blood tests available for translation on global scale in both high- and low-resource settings, Gurkan said.

The work at Case will be conducted in collaboration with researchers at multiple other institutions, which, in addition to the centers conducting the clinical studies, include University Hospitals Rainbow Babies and Childrens Hospital, Childrens Healthcare of Atlanta, and Childrens Hospital of Montefiore.

Success in SCD could pave the way for similar benefits in other genetic diseases, which is the goal of the National Institutes of Health (NIH).

The reason the NIH is so focused on curing SCD is that it is the poster child for gene-editing efforts, said Gurkan. If we can prove that we can cure an inherited mutation like SCD effectively and safely, then you convince the funders and the public that it is worth the expense and the effort to go after more complex inherited diseases which are less understood.

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Case Researchers Awarded $3.7 Million to Test Emerging SCD Gene... - Sickle Cell Anemia News

Induced pluripotent stem cells and CRISPR reversed diabetes in mice – Drug Target Review

Induced pluripotent stem cells made to produce insulin and CRISPR, used to correct a genetic defect, cured Wolfram syndrome in mice.

Using induced pluripotent stem cells (iPSCs) produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes called Wolfram syndrome, researchers transformed the human stem cells into insulin-producing cells and used CRISPR-Cas9 to correct a genetic defect that had caused the syndrome. They then implanted the cells into lab mice and cured the unrelenting diabetes in those models.

The findings, from researchers at Washington University School of Medicine in St. Louis, US, suggest this CRISPR-Cas9 technique may hold promise as a treatment for diabetes, particularly the forms caused by a single gene mutation and it also may be useful one day in some patients with the more common forms of diabetes, such as type 1 and type 2.

This is the first time CRISPR has been used to fix a patients diabetes-causing genetic defect and successfully reverse diabetes, said co-senior investigator Dr Jeffrey Millman, an assistant professor of medicine and of biomedical engineering at Washington University. For this study, we used cells from a patient with Wolfram syndrome because, conceptually, we knew it would be easier to correct a defect caused by a single gene. But we see this as a stepping stone toward applying gene therapy to a broader population of patients with diabetes.

Wolfram syndrome is caused by mutations to a single gene, providing the researchers an opportunity to determine whether combining stem cell technology with CRISPR to correct the genetic error also might correct the diabetes caused by the mutation.

Researchers at Washington University School of Medicine in St. Louis have transformed stem cells into insulin-producing cells. They used the CRISPR gene-editing tool to correct a defect that caused a form of diabetes, and implanted the cells into mice to reverse diabetes in the animals. Shown is a microscopic image of insulin-secreting beta cells (insulin is green) that were made from stem cells produced from the skin of a patient with Wolfram syndrome [credit: Millman lab Washington University].

Millman and his colleagues had previously discovered how to convert human stem cells into pancreatic beta cells. When such cells encounter blood sugar, they secrete insulin. Recently, these researchers developed a new technique to more efficiently convert human stem cells into beta cells that are considerably better at controlling blood sugar.

In this study, they took the additional steps of deriving these cells from patients and using the CRISPR-Cas9 gene-editing tool on those cells to correct a mutation to the gene that causes Wolfram syndrome (WFS1). Then, the researchers compared the gene-edited cells to insulin-secreting beta cells from the same batch of stem cells that had not undergone editing with CRISPR.

In the test tube and in mice with a severe form of diabetes, the newly grown beta cells that were edited with CRISPR more efficiently secreted insulin in response to glucose. Diabetes disappeared in mice with the CRISPR-edited cells implanted beneath the skin and the animals blood sugar levels remained in normal range for the entire six months they were monitored. Animals receiving unedited beta cells remained diabetic. Although their newly implanted beta cells could produce insulin, it was not enough to reverse their diabetes.

We basically were able to use these cells to cure the problem, making normal beta cells by correcting this mutation, said co-senior investigator Dr Fumihiko Urano, the Samuel E. Schechter Professor of Medicine and a professor of pathology and immunology. Its a proof of concept demonstrating that correcting gene defects that cause or contribute to diabetes in this case, in the Wolfram syndrome gene we can make beta cells that more effectively control blood sugar. Its also possible that by correcting the genetic defects in these cells, we may correct other problems Wolfram syndrome patients experience, such as visual impairment and neurodegeneration.

Were excited about the fact that we were able to combine these two technologies growing beta cells from induced pluripotent stem cells and using CRISPR to correct genetic defects, Millman said. In fact, we found that corrected beta cells were indistinguishable from beta cells made from the stem cells of healthy people without diabetes.

Moving forward, the process of making beta cells from stem cells should get easier, the researchers said. For example, the scientists have developed less intrusive methods, making iPSCs from blood and they are working on developing stem cells from urine samples.

The study is published in Science Translational Medicine.

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Induced pluripotent stem cells and CRISPR reversed diabetes in mice - Drug Target Review

Gene Therapy for Inherited Genetic Disorders Market Key Companies and Analysis Top Trends by 2028 Cole Reports – Cole of Duty

Global Gene Therapy for Inherited Genetic Disorders Market: Overview

Rapid advances in mammalian DNA sequencing technologies over the past several years have enabled the identification of the aberrant genes responsible for a vast spectrum of genetic disorders. Gene therapy as a novel approach inarguably holds profound potential in finding universal therapeutic alternatives to treating inherited genetic disorders. Gene therapy for inherited genetic disorders entails introducing a functional copy of the defective gene to make up for the missing function, and can be accomplished using in vivo or ex vivo gene transfer.

Gene therapy for inherited genetic disorders has generated groundswell of interest in the research fraternity in finding cure for or in treatment of Mendelian genetic error causing rare diseases. Particularly, gene therapy in recent years has held promising potential in the treatment of a range of recessive gene disorders most notably sickle cell anemia, hemophilia, muscular dystrophy, cystic fibrosis, and other monogenic disorders. The axes of developments in the gene therapy for inherited genetic disorders market have been in the U.S., Europe, China, and Australia.

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Global Gene Therapy for Inherited Genetic Disorders Market: Notable Developments

Growing body of clinical studies done on mice models have unrivalled troves of preclinical data, which bodes well for the effectiveness of gene therapy for inherited genetic disorders. New approaches in the gene therapy for inherited genetic disorders market are being adopted to bring progress in this direction. In this regard, Salmeterol, a medicine approved for asthma, has shone a new light. The vasodilator to be used along with gene therapy has shown potential in increasing the effectiveness of the therapy for Glycogen storage disease type II (Pompe disease).

A team of investigator led by the researcher at Duke University Medical School discussed the preclinical data recently at 2019 annual meeting of the American Society of Gene & Cell Therapy. The preclinical data showed that the Asthma medicine reduces the accumulation of toxic glycogen accumulated in lysosome. The researchers concluded that it holds potential as an adjunctive therapy, and building on that may pave way for novel approaches on gene therapy for inherited genetic disorders.

Efforts to translate the findings of clinical research on gene therapy for inherited disorders to make the therapy a part of standard treatment has caught momentum in recent times. In this regard, vectors containing non-viral vectors have attracted the attention of scientists. A team of researchers at Fred Hutchinson Cancer Research Center in 2019 found that gold nanoparticles enable them to deliver gene-editing tools to blood stem cells in lab models. This might, they opined, pave way for more practicaland accessiblegene therapies for inherited disorders, notably for treating life-threatening blood disorders. Gene therapies were mediated by CRISPR. In the coming years they hope to collaborate with companies with commercial interest to develop the therapy for patient populations.

Some of the bigplayerseyeing promising stakes in the gene therapy for inherited genetic disorders market areSpark Therapeutics Inc., Orchard Therapeutics, Novartis AG, bluebird bio Inc., and BioMarin Pharmaceutical.

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Global Gene Therapy for Inherited Genetic Disorders Market: Key Drivers

Since 2000, scores of clinical trials involving patients with inherited genetic disorders have raised hopes of the medical fraternity of the potential of gene therapies. Thus far, more than 5000 clinical trials on gene therapy have been conducted, especially for hard-to-treat diseases. Diseases such as inherited blindness and leukemia have seen the efficacy and safety of gene therapies. Advances in bioengineering are expected to invigorate pre-clinical pipelines. In the not-so-distant future, success of more protocols will catalyze the prospects of the gene therapy for inherited genetic disorders market.

Further, advances have been made in viral and non-viral vectors with the purpose of making gene transfer more efficient, thereby boosting the gene therapy for inherited genetic disorders market. Particularly, new approaches emerged with the aim of making vectors more powerful.

Global Gene Therapy for Inherited Genetic Disorders Market: Regional Assessment

On the regional front, Asia Pacific bears considerable potential in the gene therapy for inherited disorders market. Of note, numerous strategic alliances have shifted their focus on the region, particularly China. The North America market has also been rising at a promising pace, driven by several gene-therapy tools and related drugs in the final stages of clinical trials. Favorable reimbursement models has also encouraged research into the gene therapy for inherited disorders.

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Gene Therapy for Inherited Genetic Disorders Market Key Companies and Analysis Top Trends by 2028 Cole Reports - Cole of Duty

Genetic variants linked with onset, progression of POAG – Ophthalmology Times

Genetic variants that are unrelated to the IOP are associated with a family history of glaucoma and play a role in the onset of primary open-angle glaucoma (POAG). Genetic variants that are related to the IOP are associated with the age at which glaucoma is diagnosed and are associated with disease progression.

What is known about POAG, the most prevalent form of glaucoma, is that increased IOP and myopia are risk factors for damage to the optic nerve in POAG.

Related: Stent offers IOP stability more than three years after surgery

A family history of glaucoma is a major risk factor for development of POAG, in light of which, therefore, genetic factors are thought to be important in the disease pathogenesis and a few genes mutations have been identified as causing POAG, according to Fumihiko Mabuchi, MD, PhD, professor, Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, Kofu, Japan.

Myopia has been shown to be a risk factor for POAG in several studies. However, it can be difficult to diagnose true POAG in myopic patients and controversy exists over whether it is real risk factor.

Myopic optic discs are notoriously difficult to assess, and myopic patients may have visual field defects unrelated to any glaucomatous process.

The prevalence of POAG increases with age, even after compensating for the association between age and IOP.

Related: Preservative-free tafluprost/timolol lowers IOP well, glaucoma study shows

Part of the storyDr. Mabuchi and his and colleagues, recounted that these factors are only part of the story.

According to Dr. Mabuchi and his colleagues, cases of POAG caused by these gene mutations account for several percent of all POAG cases, and most POAG is presumed to be a polygenic disease.

Recent genetic analyses, the investigators explained, have reported genetic variants that predispose patients to development of POAG and the additive effect of these variants on POAG, which are classified as two types.

The first genetics variants are associated with IOP elevation.

Related: Sustained-release implant offers long-term IOP control, preserved visual function

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Genetic variants linked with onset, progression of POAG - Ophthalmology Times

Nobel laureate Luc Montagnier inaccurately claims that the novel coronavirus is man-made and contains genetic material from HIV – Health Feedback

CLAIM

"this coronavirus genome contained sequences of another virus [] the HIV virus (AIDS virus)"

DETAILS

Inaccurate: Genomic analyses indicate that the virus has a natural origin, and was not engineered. The so-called unique protein sequence insertions found in the 2019 novel coronavirus can be found in many other organisms, not just HIV.

KEY TAKE AWAY

Genomic analyses of the novel coronavirus show that it was not engineered. In addition, the claim that its genome contains inserted HIV sequences is based on a now-withdrawn preprint of a study that contained significant flaws in design and execution. The so-called HIV insertions identified by the authors are in fact gene sequences that can also be found in many other organisms besides HIV.

REVIEW Numerous articles published in April 2020 report that Nobel laureate Luc Montagnier claimed that SARS-CoV-2 is a manipulated virus that was accidentally released from a laboratory in Wuhan, China and that Indian researchers have already tried to publish the results of the analyses that showed that this coronavirus genome contained sequences of another virus [] the HIV virus (AIDS virus). The claim that SARS-CoV-2 contains HIV insertions began circulating in January 2020, and was propagated by outlets such as Zero Hedge and Infowars. Health Feedback covered this claim in early February 2020, and found it to be inaccurate.

Firstly, genomic analysis of the novel coronavirus, published in Nature Medicine, has demonstrated that the virus is not the product of bioengineering, but is rather of natural origin[1]. The current most likely theory, based on what scientists know about viral evolution, is that the virus first emerged in pangolins or bats (or both) and later developed the ability to infect humans. This ability to infect human cells is conferred by the so-called spike (S) protein, which is located on the surface of the enveloping membrane of SARS-CoV-2.

After the 2003-2005 SARS outbreak, researchers identified a set of key amino acids within the S protein which give SARS-CoV-1 a super-affinity for the ACE2 target receptor located on the surface of human cells[2,3]. Surprisingly, the S protein of the current SARS-CoV-2 does not contain this optimal set of amino acids[1], yet is nonetheless able to bind ACE2 with a greater affinity than SARS-CoV-1[4]. This finding suggests that SARS-CoV-2 evolved independently and undermines the claim that it was manmade[1]. Indeed, the best engineering strategy would have been to harness the known and efficient amino acid sequences already described in SARS-CoV-1 order to produce a more optimal molecular design for SARS-CoV-2. The authors of the Nature Medicine study[1] concluded that Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.

Secondly, the claim that SARS-CoV-2 contains HIV insertions is based on a preprint of a research study uploaded to bioRxiv on 2 February 2020. A preprint is a study in progress that has not been peer-reviewed by other scientists. The authors of the preprint, titled Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag, claimed to have found 4 insertions in the spike glycoprotein (S) which are unique to 2019-nCoV and are not present in other coronaviruses. The authors further asserted that all of [these inserts] have identity/similarity to amino acids residues in key structural proteins of HIV-1 [which] is unlikely to be fortuitous in nature.

The work was swiftly criticized by experts. In this Forbes article, Arinjay Banerjee, a postdoctoral fellow at McMaster University who has studied coronaviruses, said that:

The authors compared very short regions of proteins in the novel coronavirus and concluded that the small segments of proteins were similar to segments in HIV proteins. Comparing very short segments can often generate false positives and it is difficult to make these conclusions using small protein segments.

Researchers also took to Twitter to demonstrate this problem first-hand. Trevor Bedford, a faculty member at the Fred Hutchinson Cancer Research Center who studies viral evolution, re-analyzed the gene and protein sequences used by the authors and found that the so-called unique inserts appeared in many other organisms, including Cryptosporidium and Plasmodium malariae, which cause cryptosporidiosis and malaria, respectively.

Assistant professor at Stanford University Silvana Konermann also checked the authors findings and came to the same conclusion, calling the similarity spurious.

This has also been independently confirmed in another published analysis[5]. In other words, these sequences are not insertions, but are rather common sequences found in numerous other organisms such as bacteria and parasites. Therefore, the existence of these sequences in SARS-CoV-2 does not provide evidence of a link to HIV, nor that scientists purposely inserted HIV sequences into the SARS-CoV-2 genome.

In summary, genomic analysis of the virus indicates that it does not contain so-called HIV insertions and that it was not engineered in a lab. Evidence points to the virus having a natural origin.

The only thing accurate about these articles is that Nobel Prize winner and virologist Luc Montagnier did in fact make these claims. Although he holds impressive scientific credentials, his claims run contrary to credible scientific evidence. And despite having won the Nobel Prize in Physiology or Medicine in 2008 for his co-discovery of the link between HIV and AIDS, Montagnier now promotes widely discredited theories such as the pseudoscience of homeopathy and that autism is caused by bacteria that emit electromagnetic waves. Articles which repeat Montagniers claims without critically evaluating their veracity exhibit the common appeal to authority fallacy, in which something is assumed to be true simply because the person saying it is considered to be an expert, thereby misleading readers into believing that this theory is scientifically credible. This demonstrates the importance of verifying scientific claims with other experts in the same field, rather than simply taking such claims from a single expert at face value.

SCIENTISTS FEEDBACK [These comments come from an evaluation of a related claim.] Aaron T. Irving, Senior Research Fellow, Duke-NUS Medical School:Its easier to believe misinformation when it is mixed with truth. The region highlighted in the pre-print is indeed an insertion in nCoV-2019 relative to its bat ancestors and indeed it has high identity to the HIV gp120/gag. However, the authors chose to align only this small region and not do a basic check on whether there were other sequences which were also homologous (showing high degree of similarity/identity). As it turned out, the region is also homologous to many unrelated sequences. As such, the conclusions drawn from the data are no longer valid and there are many open-ended questions regarding this region highlighted. I see the authors themselves agree with this criticism by other scientists and have voluntarily withdrawn their preprint pending a much deeper investigation.

The author of this article by European Scientist also compared the genome sequences of SARS-CoV-2 and HIV using the Basic Local Alignment Search Tool (BLAST), developed by the U.S. National Institutes of Health, and found no significant similarity, explaining that In plain English, SARS-CoV-2 is not made of the bat coronavirus and small bits of the HIV virus. Readers who wish to verify the level of sequence identity between the two viruses for themselves are welcome to follow the steps listed in the article.

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Nobel laureate Luc Montagnier inaccurately claims that the novel coronavirus is man-made and contains genetic material from HIV - Health Feedback