GDA 2014 Honoree: Dr. Omid Farokhzad Wall Street Journal Interview Cellular Surgeons: New Era of Nanomedicine New York Academy of Sciences Event ecancertv: Polymeric Nanoparticles for Medical Applications Our Research
Nanotechnology has generated a significant impact in nearly every aspect of science. Our research seeks novel nanomaterials and nanotechnologies in order to develop advanced drug delivery systems with the promise to improve health care. Highly interdisciplinary and translational, our research is focused on multifunctional, nanoparticle-based drug delivery systems. We seek to improve nanoparticle synthesis and formulation and its therapeutic efficacy. Additionally, we develop robust engineering processes to accelerate translation of nanoparticle-based drugs into the drug development pipeline. At the same time, we emphasize a fundamental understanding of the interface between nanomaterials and biological systems. Read our recent reviews below:
See below for some of our selected research articles. Click on images for more detail:
Transepithelial transport of fc-targeted nanoparticles by the neonatal fc receptor for oral delivery:
A study on the immunocompatibility properties of lipid-polymer hybrid nanoparticles with heterogeneous surface functional groups:
Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection:
Synthesis of Size-Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single-Layer Microchannels:
Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles:
Development of poly(ethylene glycol) with observable shedding:
Congratulations to Nazila Kamaly for her appointment as an Associate Professor at Technical University of Denmark (01/01/16)
Congratulations to Jun Wu for his appointment as a Professor at Sun Yat-sen University, China (01/01/16)
Congratulations to Christian Vilos for securing the Chilean Grant (Fondecyt)! (01/30/16)
Congratulations to Naomi Morales-Medina for securing an undergraduate National Aeronautic and Space Administration (NASA) Fellowship for minorities in STEM fields! (10/19/15)
Congratulations to Christian Vilos for his promotion to Associate Professor at Center for Integrative Medicine and Innovative Science (CIMIS) in Faculty of Medicine in Andres Bello University! (09/10/15)
Congratulations to Won Il Choi for securing a Senior Researcher position at the Korea Institute of Ceramic Engineering and Technology! (09/10/15)
Congratulations to Jining Huang for getting admission in the Bioengineering PhD Program at Caltech. (03/24/15)
Welcome Dr. Sejin Son to join our team! (10/31/14)
Welcome Dr. Dmitry Shvartsman to join our team! (09/19/14)
Welcome Dr. Harshal Zope to join our team! (06/15/14)
Welcome Dr Yanlan Liu, Dr. Xiaoding Xu and Dr. Arif Islam to join our team! (03/12/14)
Welcome Dr. Basit Yameen to join our team! (09/09/2013)
Congratulations to Dr. Archana Swami for her poster prize at the MIT Polymer Day Symposium! (05/02/2013)
Welcome Dr. Mikyung Yu, Dr. In-hyun Lee, Dr. Won IL Choi, Dr. Renata Leito and Dr. Cristian Vilos to join our team! (05/02/2013)
Congratulations to Dr. Archana Swami for receiving an 'Outstanding Paper' award from the ASME at NEMB2013! (31/01/2013)
Welcome Dr. Giuseppe Palmisano to join our team! (04/01/12)
Congratulations to Steffi Sunny for securing a PhD position on the Applied Science and Engineering PhD program at Harvard University! (04/01/12)
Congratulations to Shrey Sindhwani for securing a Physician Scientist Training Program (MD-PhD) position at the University of Toronto! (04/01/12)
Congratulations to Dr. Xiaoyang Xu on the award of his National Cancer Institute funded Ruth L. Kirschstein National Research Service Award Post-doctoral Fellowship! (01/03/2012)
Congratulations to Dr. Jinjun Shi on the award of his National Cancer Institute K99/R00 Career Award! (11/30/2011)
Congratulations to Dr. Jinjun Shi for his BWH Biomedical Research Institute award! (11/10/2011)
Welcome Dr. Nazila Kamaly to join our team! (01/25/2011)
Welcome Dr. Jun Wu, Dr. Xueqing Zhang and Changwei Ji to join our team! (11/15/2010)
Welcome Dr. Suresh Gadde to join our team! (12/15/2009)
Welcome Dr. Xiaoyang Xu to join our team! (10/19/09)
Welcome Dr. Archana Mukherjee to join our team! (08/19/09)
Immunocompatibility properties of lipid-polymer hybrid nanoparticles with heterogeneous surface functional groups, Salvador-Morales C, Zhang L, Langer et al, Biomaterials, 30 (2009) 2231.
Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection, Xiao Z, Levy-Nissenbaum E, Alexis F et al, ACS Nano, 6 (2012) 696.
Synthesis of size-tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single-layer microchannels., Rhee M, Valencia M, Rodriguez MI et al, Advanced Materials, 23 (2011) H79.
Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles, Valencia PM, Hanewich-Hollatz MH, Gao W et al, Biomaterials, 23 (2011) 6226.
Poly (ethylene glycol) with Observabel Shedding, Valencia PM, Hanewich-Hollatz MH, Gao W et al, , 23 (2010) 6567.
Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile, Hrkach J, Von Hoff D, Ali MM et al, Science Translational Medicine, 4 (2012) 128ra39.
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation, N Kamaly, Z Xiao, P Valencia et alChem. Soc. Rev, 41 (2012) 2971.
Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers, F. Gu, L. Zhang, B. A. Teply et alPNAS, 105 (2008) 2586.
Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on bi-fluorescence resonance energy transfer, V Bagalkot, L Zhang, E Levy-Nissenbaum et alNano Lett., 7 (2007) 3065.
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo, O. Farokhzad, J. Cheng, B. A. Teply, et al PNAS, 103 (2006) 6315.
Read more:
Laboratory of Nanomedicine and Biomaterials
- Is there an alternative to radiation - November 8th, 2009 [November 8th, 2009]
- Taiwan exploring how nanotech affects health - November 8th, 2009 [November 8th, 2009]
- A new way of treating cancer on the way? - November 8th, 2009 [November 8th, 2009]
- Lasers can destroy cancer cells - November 8th, 2009 [November 8th, 2009]
- Fluorescent molecules can be biomarkers - November 8th, 2009 [November 8th, 2009]
- Quick blood tests by using a nanodevice - November 8th, 2009 [November 8th, 2009]
- Where will medicine be 20 years from now - November 8th, 2009 [November 8th, 2009]
- History of nanotechnology - November 8th, 2009 [November 8th, 2009]
- Nanotech and Cancer - November 8th, 2009 [November 8th, 2009]
- Nanotechnology in medicine - November 8th, 2009 [November 8th, 2009]
- How does cancer start - January 25th, 2010 [January 25th, 2010]
- Lung cancer symptoms - January 26th, 2010 [January 26th, 2010]
- Signs of breast cancer - January 27th, 2010 [January 27th, 2010]
- Famous people with cancer - January 29th, 2010 [January 29th, 2010]
- Metastatic renal cancer - January 30th, 2010 [January 30th, 2010]
- What causes skin cancer - January 31st, 2010 [January 31st, 2010]
- How many people die from cancer each year - February 1st, 2010 [February 1st, 2010]
- How much money is spent on cancer research - February 2nd, 2010 [February 2nd, 2010]
- Colon cancer warning signs - February 4th, 2010 [February 4th, 2010]
- Prostate cancer symptoms - February 4th, 2010 [February 4th, 2010]
- Nano-devices that cross blood-brain barrier open door to treatment of cerebral palsy - April 25th, 2012 [April 25th, 2012]
- Nano-devices that cross blood-brain barrier open door to treatment of cerebral palsy, other neurologic disorders - April 25th, 2012 [April 25th, 2012]
- Nanomaterial properties in complement activation: lessons from nanomedicine - Video - May 4th, 2012 [May 4th, 2012]
- OMICS Group :: International Conference and Exhibition on Nanotechnology - May 4th, 2012 [May 4th, 2012]
- Use of Nanotechnology in Medicine [FOX 11-27-2011] - Video - May 4th, 2012 [May 4th, 2012]
- Cancer Nanomedicine - Detection - Video - May 4th, 2012 [May 4th, 2012]
- Cancer Nanomedicine - Video - May 4th, 2012 [May 4th, 2012]
- HBIO Reports First Quarter 2012 Revenue Growth of 8% Over First Quarter 2011 - May 5th, 2012 [May 5th, 2012]
- Nano science, focus of Education Ministry - May 7th, 2012 [May 7th, 2012]
- Drug-resistant Bacteria - Designing Nanoparticles For High Antibiotic Doses - May 7th, 2012 [May 7th, 2012]
- Research and Markets: Global Market for Nano Silver - May 10th, 2012 [May 10th, 2012]
- Cracking study makes nanotech breakthrough - May 10th, 2012 [May 10th, 2012]
- Nanoparticles may pose environmental threat - May 16th, 2012 [May 16th, 2012]
- Global Nanobiotechnology Industry - May 17th, 2012 [May 17th, 2012]
- 'Inability to give back Singur land my biggest regret' - May 20th, 2012 [May 20th, 2012]
- 'KOREA PACK 2012' for Packing process industry to be held at KINTEX - May 23rd, 2012 [May 23rd, 2012]
- New ISO Technical Report Guides Characterization of Nanomaterials in Toxicology - May 29th, 2012 [May 29th, 2012]
- DNA strands create tiniest Smileys - May 30th, 2012 [May 30th, 2012]
- Health and fitness agenda: Evolution Asia Yoga Conference - June 2nd, 2012 [June 2nd, 2012]
- UC Davis work in humanities receives $150,000 in UC-wide grants - June 2nd, 2012 [June 2nd, 2012]
- Computer-designed proteins 'may help fight variety of flu viruses' - June 3rd, 2012 [June 3rd, 2012]
- 'Nano technology' [program can pay off big for IRSC students - June 3rd, 2012 [June 3rd, 2012]
- Computer-designed proteins programmed to disarm variety of flu viruses - June 3rd, 2012 [June 3rd, 2012]
- Jugaad innovators don't plan - they improvise - June 6th, 2012 [June 6th, 2012]
- Health and fitness agenda: World Blood Donor Day - June 9th, 2012 [June 9th, 2012]
- OMICS Group :: Journal of Nanomedicine - June 9th, 2012 [June 9th, 2012]
- Researchers develop a 'time bomb' to fight cardiovascular disease - June 10th, 2012 [June 10th, 2012]
- Nanotechnologists develop a 'time bomb' to fight cardiovascular disease - June 10th, 2012 [June 10th, 2012]
- 'Time bomb' to fight cardiovascular disease developed - June 11th, 2012 [June 11th, 2012]
- Asia's First Graphene Nano-Tech Facility Opens In Singapore - June 13th, 2012 [June 13th, 2012]
- How worms are pioneering remote control medicine - June 13th, 2012 [June 13th, 2012]
- Golden Helix Establishes Direct Presence in Japan - June 13th, 2012 [June 13th, 2012]
- STDs Blocked by Nano Gel, Study Suggests - June 15th, 2012 [June 15th, 2012]
- Real Products, Different Results - June 15th, 2012 [June 15th, 2012]
- The Puridone Program - A Breakthrough for Painkiller Addiction - June 15th, 2012 [June 15th, 2012]
- Six startup medical device firms compete in Memphis for fame and fortune - June 19th, 2012 [June 19th, 2012]
- International Nanomedicine Conference bound for Sydney: July 2-4, 2012 - June 19th, 2012 [June 19th, 2012]
- Taming light with graphene - June 21st, 2012 [June 21st, 2012]
- Today on New Scientist: 25 June 2012 - June 26th, 2012 [June 26th, 2012]
- A step towards the future - July 1st, 2012 [July 1st, 2012]
- Genia Technologies Collaborates with Professors Jingyue Ju at Columbia and George Church at Harvard to Develop a ... - October 4th, 2012 [October 4th, 2012]
- Scientists Invited To Submit Proposals For Biological Research In Space - October 4th, 2012 [October 4th, 2012]
- Research and Markets: Micro-Nano Technology XIII from the 13th Annual Conference of Chinese Society of Micro-Nano ... - October 6th, 2012 [October 6th, 2012]
- $80M research facility to open at UMass Lowell - October 6th, 2012 [October 6th, 2012]
- Nano-revolution in drugs delivery - October 8th, 2012 [October 8th, 2012]
- SENAI/SESI of Sao Paulo Selects NanoProfessor as Foundation for "Nanomundo" Nanotechnology Education Initiative - October 8th, 2012 [October 8th, 2012]
- Delivering an integral approach to emotional and mental health - October 9th, 2012 [October 9th, 2012]
- NanoGuardian's On-Dose NanoEncryption Brand Protection Technology to Be Presented at AAPS Annual Meeting - October 11th, 2012 [October 11th, 2012]
- Il Nano Mondo del professor Ennio Tasciotti - Video - October 30th, 2012 [October 30th, 2012]
- Deakin University - Practical Science - Nano medicine - Video - October 30th, 2012 [October 30th, 2012]
- 2012 Deakin University 3 Minute Thesis Finalist - Jarrad Altimari - Video - October 30th, 2012 [October 30th, 2012]
- Nano Medicine from "Development of Nanotechnology in Hong Kong" - Video - October 30th, 2012 [October 30th, 2012]
- NANO Medicine 1 3 xvid - Video - October 30th, 2012 [October 30th, 2012]
- Nanolääke // Nano medicine - Video - October 30th, 2012 [October 30th, 2012]
- NANO Medicine (1-3) - Video - October 30th, 2012 [October 30th, 2012]
- Jefferson County, Colorado's Bioscience Industry - Video - October 30th, 2012 [October 30th, 2012]
- NanoMission - Nanomedicine NanoBot - Video - October 30th, 2012 [October 30th, 2012]
- Study aims to unlock mysteries of autism - November 20th, 2012 [November 20th, 2012]
- Catherine Griwkowsky - November 22nd, 2012 [November 22nd, 2012]
- Kulkarni to be feted at Bangalore Nano 2012 - November 26th, 2012 [November 26th, 2012]