Archibald Powers Comets Past Crunch

November 26, 2014 - American Hockey League (AHL) Utica Comets The Utica Comets exacted revenge and got back to their winning ways all in one night with a 5-4 victory over the Syracuse Crunch on Wednesday at the Utica Memorial Auditorium.

Darren Archibald (2-1-3) lit up the scorer's sheet in this one. His two-goal night, including the game-winner, helped push the Comets to their first win in three games. Brandon DeFazio (1-1-2), Nicklas Jensen (0-2-2), and newcomer Will Acton (0-2-2) all contributed to the Comets success with two points apiece.

After a scoreless first period, the second stanza was the polar opposite with a total of six goals combined.

A little over one minute in to the second period, the Crunch broke the scoreless tie. Yanni Gourde followed up a diving shot from Phillipe Paradis, and popped in a rebound past Joacim Eriksson's right side for his ninth goal of the season.

The Comets didn't stray from their hard-checking game plan and found the equalizer 5:37 into the second period. After a battle along the boards, DeFazio retrieved the puck and stick-handled his way through the defense. The 25-year old winger sniped one clear to the far side of Andrei Vasilevskiy, who hadn't let a goal in since the first period of the Toyota Frozen Dome Classic this past Saturday. Archibald was credited with the only assist on the play. This was DeFazio's eighth goal and Archibald's fifth assist on the season.

Utica wanted the lead, and they got the lead at 11:27. After a 3-on-2 rush, DeFazio found his way around the back of Vasilevskiy's net and shot the puck towards the goaltender's right side. After a rebound and some confusion in front of the net, Archibald snuck the puck into the net for his second goal of the season. Will Acton recorded his first point as a Comet by tallying the secondary assist on the play.

Just four minutes later the Comets doubled their lead and found the back of the net again, this time on the power play. After a feed to Alex Biega from Jensen, Biega took one of his signature slapshots from the center point. The puck was blocked down by Vasilevskiy but Alexandre Grenier quickly found the rebound and slipped it by the Crunch goaltender for a power-play goal and a3-1 lead.

Syracuse quickly answered back just 27 seconds later from a Paradis slapshot that got deflected and bounced straight up over Eriksson's glove side to close the gap to 3-2. Jake Dotchin and Gourde both tallied assists on the play.

At the tail end of the second period, Utica re-gained their two-goal lead with another power-play goal at the 18:34 mark. After setting up on the attack, Hunter Shinkaruk fired a quick feed to Henrik Tommernes. Tommernes slipped it to Ronalds Kenins who took control of the puck and approached the hashmarks to the right on the Crunch's net. He fired a quick shot top shelf to the far side of the Syracuse goaltender to extend the Comets lead to 4-2.

Almost halfway through the third period, Syracuse mounted their comeback after Biega took a tripping penalty. At 11:29 Nikita Nesterov passed the puck to Jonathan Marchessault who buried a one-timer past Eriksson's right side for their first power-play goal of the night to make it 4-3.

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Archibald Powers Comets Past Crunch

AstraZeneca/Amgen's Brodalumab Excels in Psoriasis Study – Analyst Blog

AstraZeneca ( AZN ) and partner Amgen ( AMGN ) announced encouraging results from the pivotal, multi-arm phase III AMAGINE-2 study (n>1800) on their psoriasis candidate, brodalumab. The study compared brodalumab with both Johnson & Johnson's ( JNJ ) Stelara and placebo in treating patients suffering from moderate-to-severe plaque psoriasis.

Results showed that a greater proportion of patients treated with brodalumab 210 mg (44.4%), brodalumab weight based group (33.6%) and brodalumab 140 mg (25.7%) achieved total clearance of skin disease as measured by the Psoriasis Area Severity Index (PASI 100). In comparison, patients under Stelara achieved 21.7% and under placebo a mere 0.6%.

Moreover, according to the PASI 75 score (at least a 75% improvement in disease severity), results showed that a higher number of patients on brodalumab 210 mg (86.3%) and the brodalumab weight based group (77%) achieved the same as compared to those on brodalumab 140 mg (66.6%), Stelara (70%) and placebo (8.1%). The other key secondary endpoints of the study were also met.

We note that the companies' AMAGINE program consists of three phase III studies - AMAGINE-1, AMAGINE-2 and AMAGINE-3. While results from the AMAGINE-1 study were out in May this year, AstraZeneca and Amgen announced encouraging results from the AMAGINE-3 study earlier in the month (read more: AstraZeneca/Amgen's Brodalumab Positive in Psoriasis Trial ).

With results from all the three studies out, the companies are now planning to discuss with regulatory authorities the global filing plan for the candidate which is expected next year.

Our Take

We are encouraged by the positive results from the AMAGINE program on brodalumab. Brodalumab is an important candidate for both AstraZeneca and Amgen. However, the psoriasis market currently looks extremely crowded with the presence of products like Stelara, Enbrel and Otezla.

Brodalumab is also being developed for the treatment of asthma. According to AstraZeneca, analyst estimates for brodalumab range between $0.5 billion and $1.5 billion.

Amgen and AstraZeneca are both Zacks Rank #3 (Hold) stocks. A better-ranked stock in the health care sector is Allergan Inc. ( AGN ) carrying a Zacks Rank #1 (Strong Buy).

ASTRAZENECA PLC (AZN): Free Stock Analysis Report

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AstraZeneca/Amgen's Brodalumab Excels in Psoriasis Study - Analyst Blog

Reel Story; Super Smash Bros Wii U

I will be journeying back to the world of my Wii U because Super Smash Brothers Wii U was released and of course I got the game.

I will start with what I hate with this game.

It plays just like Super Smash Brothers Brawl on the Wii. Super Smash Brothers Brawl played too much like Super Smash Brothers Melee on the Game Cube. Super Smash Brothers Melee was a great follow-up to Super Smash Brothers on the Nintendo 64.

Do you get where I am going with this?

In case I lost you, this new game feels like a recycled version of a recycled version of Super Smash Brothers Melee. To me there are not enough differences in style of game play from the previous games. All this feels like is Super Smash Brothers Melee with Wii U graphics and the Final Smash feature of Super Smash Brother Brawl.

Im not saying the game is not fun to play because it is. When you have a bunch of people to play with this game can be loads of fun. That said, because it really is the same game yet again, with the same game mechanics yet again, it can become stale and repetitive.

The character selection in this game goes to both extremes with me. On one hand I find it uninspired and on the other I think it is great.

The uninspired part comes from the fact that characters from the Mario and Pokemon franchises flood the roster, over possible character from The Legend of Zelda or Metroid. Sure from Zelda we have Link, Ganondorf, Zelda, Toon Link and Shiek but what about other characters?

Aganhim from A Link to the Past would be awesome. What about the Skull Kid from Majoras Mask? Or a Staflos? What about the old man from the first game that gives you the sword? What about some of the playable characters from Hyrule Warriors?

Metroid does not have a lot of characters to choose from. Kraid, the giant dinosaur that is Godzilla size is way too big for a game like this. Mother Brain could work but only if she has her body from Super Metroid. Mother Brain is usually just a biological computer locked in a glass container. Golden Torizo from Super Metroid would also be pretty sweet.

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Reel Story; Super Smash Bros Wii U

The Voice of Gideon from The Flash Revealed!

Last nights episode of The CWs new DC Comics series The Flash introduced a new character of sorts with Gideon, the super computer used byTom Cavanaghs Dr. Harrison Wells. Today, TVLinehas learned that the voice of Gideon was none other than fan-favorite actressMorena Baccarin!

Best knownfor appearing in Firefly, V, and Homeland, Baccarin has also lent her voice to a number of other DC projects in the past. She voiced Black Canary on the Justice League animated series, Cheetah on Batman: The Brave and The Bold, and Taliah al Ghul in this yearsdirect-to-home-video animated feature Son of Batman. Shes also already set to appear next year as Dr. Leslie Thompkins on FOXs Gotham. Whether she will return as the voice of Gideon on The Flash remains to be seen, although the odds appear to be quite favorable that shell be back.

Starring Grant Gustin,Candice Patton, Rick Cosnett, Danielle Panabaker, Carlos Valdes, Tom Cavanagh and Jesse L. Martin, The Flash airs Tuesdays at 8 P.M. on The CW.

Read our recap of last nights episode, Power Outage,right hereand check out the trailer for next weeks much-anticipated Arrow and The Flash crossoverhere.

(Photo Credit:Fayesvision / WENN)

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The Voice of Gideon from The Flash Revealed!

CSU Researchers Using Stem Cell Therapy To Treat Kidney Disease In Cats

FORT COLLINS, Colo. (CBS4) Researchers at Colorado State University are using stem cell therapy to treat kidney disease in cats. Theyre hoping to learn if stem cells can stop the progression of the disease.

Its the first feline stem cell program in the country which offers hope for the estimated 75 million pet cats in the U.S.

As cats age, a third or more develop chronic kidney disease. The studies underway at CSU may help both the cats and eventually their humans.

Squeakers (credit: CBS)

Squeakers is a domestic short hair, 15 years old, part Siamese and ill.

Shes actually just recently diagnosed with chronic kidney disease, said veterinarian Dr. Jessica Quimby.

There is no cure for feline kidney disease except a transplant, so Squeakers owner has entrusted her to the veterinarians at CSU.

Her kidneys are a little bit smallish and a little irregular, said Quimby.

For five years, Quimby and her colleagues have been running clinical trials on cats in the early stages of kidney disease. They inject them with stem cells harvested from the fat of healthy cats.

Weve seen variable results. Some kittens do get a little bit improvement in their kidney function, said Quimby. Right after we give the stem cells sometimes its just the same.

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CSU Researchers Using Stem Cell Therapy To Treat Kidney Disease In Cats

Tremendous progress in the development of skin stem cell treatments for butterfly children

27.11.2014 - (idw) IMBA - Institut fr Molekulare Biotechnologie der sterreichischen Akademie der Wissenschaften GmbH

Scientists at IMBA Institute of Molecular Biotechnology of the Austrian Academy of Sciences in Vienna have made a major advancement towards a future therapy for butterfly children. A treatment with fibroblasts generated from induced pluripotent stem cells has been highly successful in mice. The next step is to establish this method in humans. Butterfly children suffer from Epidermolysis Bullosa (EB), a debilitating skin disease. It is caused by a genetic defect that leads to a deficiency or complete lack of various structural proteins. In one particularly severe form, the protein collagen 7 is either missing or present only in insufficient amounts. If that bond is missing, the skin forms blisters or tears at the slightest mechanical pressure, leading to wounds and inflammation that require extensive treatment with creams and bandages. Often these constant lesions also lead to aggressive forms of skin cancer.

Presently there is no cure for this disease. But there are promising approaches that could lead to successful treatments in the future. One of them is a method called fibroblast injection. In this procedure, fibroblasts are injected between the layers of the skin, where they can produce the necessary collagen 7.

Researchers at IMBA under the leadership of Arabella Meixner have now been successful in developing this method to treat mice affected by EB. The individual steps of this treatment have been worked out and carefully tested in many years of laboratory work, and the results have now been published in the scientific journal Science Translational Medicine.

First the scientists returned skin cells of the diseased mice to the stem cell stage and then repaired the genetic defect, the root cause of the disease. Then the researchers transformed stem cells back into fibroblasts.

Before the repaired fibroblasts could be reintroduced into the organism, measures to prevent inflammation or rejection were necessary. In this study the researchers conducted a type of toxicity test, and the results were very promising. After several months of observation, no adverse immune reactions occurred, and the risk of skin cancer did not increase. That is an important consideration because butterfly children already have a greatly increased risk of skin cancer.

The next step is to establish this skin stem cell treatment in humans. To achieve that, the IMBA scientists intend to look for partners with clinical experience. For severe forms of Epidermolysis Bullosa, a systemic application needs to be developed to spread the cells throughout the entire body via the bloodstream to reach epithelial tissues that are more difficult to access, for example the mucous membranes in the mouth or bowels. Often in butterfly children with milder forms of the disease, only certain areas of the skin are affected. The skin stem cell therapy with local injections successfully tested on mice could lead to a valuable treatment method in the very near future.

The project conducted by IMBA scientists was initiated by the patient organization DEBRA Austria, and has had the financial support of the association and of other generous supporters since 2009. DEBRA's mission is to ensure that butterfly children receive competent specialized medical care and to promote research into options to relieve and cure EB. Further thanks also go to our funding and cooperation partners sterreichische Lotterien and FK Austria Wien.

Original publication: Wenzel et. al., iPSC-based cell therapy for Recessive Dystrophic Epidermolysis Bullosa. Science Translational Medicine. 2014.

Scientific Contact: Dr. Arabella Meixner, Research Lead Tel. +43 664 2018084 arabella.meixner@imba.oeaw.ac.at Weitere Informationen:http://www.imba.oeaw.ac.at

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Tremendous progress in the development of skin stem cell treatments for butterfly children

Whole Health Tips weekly review, Diabetes, Whole Person Health, Christian Spirituality, Stress Re… – Video


Whole Health Tips weekly review, Diabetes, Whole Person Health, Christian Spirituality, Stress Re...
We review several brief hangouts on the subject of whole person health and diabetes. This whole health approach is from a Christian perspective.

By: Stan Lang

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Whole Health Tips weekly review, Diabetes, Whole Person Health, Christian Spirituality, Stress Re... - Video

Develop Interest in Worshipping God : Spirituality Video by Baba Shivanand Jii – Video


Develop Interest in Worshipping God : Spirituality Video by Baba Shivanand Jii
Deep Meditation Videos : Baba Shivanand says that a person have to develop interest in worshiping god so that he get full access to the divine.

By: Speaking Tree

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Develop Interest in Worshipping God : Spirituality Video by Baba Shivanand Jii - Video

Inner Balance of Responsibility (Karma) and Spirituality (Yoga) – BK Shivani on Dadi Janki (Hindi) – Video


Inner Balance of Responsibility (Karma) and Spirituality (Yoga) - BK Shivani on Dadi Janki (Hindi)
Attaining Blessing and Blissings thru Balance of Yoga and Karma(Action) - BK Shivani on Dadi Janki (Hindi) Main Points from the episode 1 : * Happiness is not based on achievement. It is not...

By: bkshivani

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Inner Balance of Responsibility (Karma) and Spirituality (Yoga) - BK Shivani on Dadi Janki (Hindi) - Video

Mayan Astrology, Mayan Zodiac Signs and Mexican Spirituality with Yuriria Robles Aguayo – Video


Mayan Astrology, Mayan Zodiac Signs and Mexican Spirituality with Yuriria Robles Aguayo
Thank you so much to the Fabulous Yuriria Robles Aguayo. You can reach her at yuroag@gmail.com A special thank you to the 3er Encuentro de Astrlogos en Mxico, ENASTROME, Mexico City....

By: Nadiya Shah

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Mayan Astrology, Mayan Zodiac Signs and Mexican Spirituality with Yuriria Robles Aguayo - Video

Know the divine in you: Smita Jayakar

Actress Smita Jayakar's account on spirituality is not a run-of-the mill book but helps you connect with your higher self

She has played mom to almost every other star in Bollywood from Shah Rukh Khan, Aishwarya Rai, Aamir Khan to Ranbir Kapoor and Ali Fazal now (in Sonali Cable). But Smita Jayakar can relate most to her characters in Hum Dil De Chuke Sanam and Astitva. She has essayed various characters of a woman as a mother, a wife, daughter on screen, theatre and television. But there's one aspect of this actress which not many know. She is a motivational speaker, can talk to spirits, cleanses auras and teaches chakra dhyan. Now with her debut book Before Tomorrow, Jayakar is all set to unravel her spiritual self to the world. Experts from an interview...

Mostly people start with fiction as a writer, you chose spirituality... Fiction never interested me. I left reading fiction almost 30 years now since I got into spirituality. The first year I joined films, I met my guru and from there my entire spiritual journey begun with Prabhuji. And ever since I have never gone back to reading fiction. I will never pick up a book on fiction. Why should I write something unreal when I know what is real? (chuckles)

How did you get into spirituality? Honestly, even I don't know how the change came about. I was introduced to my first guru by my husband. I went with nothing in my mind, I didn't know where it was heading and didn't know where it would end. But then I met him everyday with a ll new questions... that somehow gave me something... at metaphysical level, I started liking it... and that's how I got sucked into it. I started enjoying it so much that I wanted to explore more. I went to Oneness and stayed connected to them for 20 years. It was there that a majority of my learning actually happened. I did a lot or processes there. I could feel a lot of cleansing happening...

Go on... Gradually they asked me hold a talk. I was not ready but my gurus saw something in me and I went to Pune for a talk on spirituality. The people really liked it and also asked for more. That boosted my confidence and then I started doing workshops and holding talks and conventions. Now I am taking workshops for almost 12 years...

Spirituality has many meanings... Just be what you are. Simplicity is what defines spirituality. It has become an issue now, but that's not what it is. People want to turn spiritual when they are old. You don't have to leave what you do to turn spiritual, you can party, eat non-veg and still be spiritual. You don't have to sacrifice to be spiritual. It is your connect to the divine, and how you do it is absolutely your business.

What change has it brought in you? I was a horrible human being before, and I didn't know better. I didn't know how to accept things in life. Whatever happens to you is for a reason. But when you turn spiritual the perception towards life changes. You remain the same, it's only how you look at things changes.

A spiritual person has to be religious? There's nothing like God. There's is this universal cosmic energy which holds us together. Spirituality doesn't mean that everyday you have to pray to God. It is just being yourself. People don't know the difference between religion and spirituality. The connect with your higher self is utmost important. That has nothing to do with how you pray, how much you pray and all... There is some consciousness which holds us together, just believe in that some power. 'Who am I' is the last step in spirituality. You don't have to be an ascetic to be a spiritual. Look at Narendra Modi, he is also very spiritual. But if he decides to become an ascetic, won't our government come to a standstill?

How do we know we need a guru? If you are inclined towards spirituality, you will also have to look for a guru. In spirituality also, there are many things to learn. So you should look for a guru for your specific need... that's called spiritual shopping. And if you are on the spiritual path you will know you need a guru. There's always a knock on your heart's door, and when you are ready, you will accept the invitation. So many times there is a knock, we have to adhere to that voice.

You have many gurus... You get stagnated in every phase, there is always a need to step up, learn more... Now I am with Dadashriji. A lot of things have opened up, am still learning, having newer experiences. There is this need to give back to the universe. The universe, nature, mother earth give us so much. There is a payback time. You have to give back. And I too am trying to give back. The more you give, the more you receive. You give hatred, and will get hatred; you give love, you will get love. Give and receive is the law of the universe.

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Know the divine in you: Smita Jayakar

International Space Station Crew Discusses Life In Space With Tennessee and Maryland Media – Video


International Space Station Crew Discusses Life In Space With Tennessee and Maryland Media
Aboard the International Space Station, Expedition 42 Commander Barry Wilmore and Flight Engineer Terry Virts of NASA discussed life and work aboard the orbital laboratory during a pair of...

By: NASA

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International Space Station Crew Discusses Life In Space With Tennessee and Maryland Media - Video