Cancer therapy shows promise for nuclear medicine treatment

PUBLIC RELEASE DATE:

9-Dec-2014

Contact: Kimberly Brown kbrown@snmmi.org 703-652-6773 Society of Nuclear Medicine @SNM_MI

Reston, Va. (December 9, 2014) - Cancer therapy can be much more effective using a new way to customize nuclear medicine treatment, researchers say in the December 2014 issue of The Journal of Nuclear Medicine. The process could also be useful for other diseases that could benefit from targeted radiation.

Targeted therapy with radiopharmaceuticals--radioactive compounds used in nuclear medicine for diagnosis or treatment--has great potential for the treatment of cancer, especially for cancer cells that have migrated from primary tumors to lymph nodes and secondary organs such as bone marrow. These disseminated tumor cells can be difficult to treat with a single targeting agent because there are dramatic differences in the number of targetable receptors on each cell.

In the study, breast cancer cells were treated with different concentrations of a cocktail of four fluorochrome-conjugated monoclonal antibodies. The amount of each antibody bound to each cell was determined using flow cytometry. Formulas were developed to "arm" the antibodies with the desired radionuclide and activity, calculate the absorbed dose to each cell, and perform a simulation of the surviving fraction of cells after exposure to cocktails of different antibody combinations. Simulations were performed for three alpha-particle emitters.

"Our approach moves radiation treatment planning for cancer therapy from the tumor level to the molecular and cellular level, with nuclear medicine serving as the treatment engine," stated Roger Howell, Ph.D., lead researcher. "The concepts are not restricted to cancer therapy but can be applied more widely to other diseases that may benefit from a targeted approach with cocktails of radiopharmaceuticals. The approach can also be extended to cocktails consisting of radiopharmaceuticals and non-radioactive agents."

The effect of the radiopharmaceutical cocktails was compared to that of single antibodies. In certain activities, cocktails outperformed single antibodies by a factor of up to 244. These findings suggest that targeted alpha therapy can be improved with customized radiolabeled antibody cocktails. Depending on the antibody combination and specific activity of the radiolabeled antibodies, cocktails can provide a substantial advantage in tumor cell killing. The methodology used in this analysis provides a foundation for pretreatment prediction of tumor cell survival in the context of personalized cancer therapy.

"This method is preferable, as it accounts for behavior of the drugs in the patient's body," Howell continues. "The beauty of either approach for planning a treatment is that the patient is not subjected to any radiopharmaceutical injections during the planning phase, which uses only fluorescent-labeled drugs. The patient is not injected with radiopharmaceuticals until the treatment phase, whereupon only a cocktail specifically optimized for that individual is administered. This spares the patient from receiving ineffective cocktails that may damage normal tissues and prevent further treatment."

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Cancer therapy shows promise for nuclear medicine treatment

Allied Healthcare Certification Video | Health Care Certification in Norcross – Video


Allied Healthcare Certification Video | Health Care Certification in Norcross
Healthcareer Certification Groups offer an alternative route to Medical, Clinical and Allied Health Care Refresher and Certification Exam Preparation to those who qualify. College is not...

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School of Medicine to build downtown

WINSTON-SALEM, N.C., Dec. 8, 2014 Wake Forest Baptist Medical Center today announced plans for a new medical education building for its School of Medicine. Funding for this $50 million capital project is part of a larger capital campaign that will be publicly launched next summer.

The medical education building will be located in the former 60 series R.J. Reynolds Tobacco Company complex, adjacent to 525@vine in Wake Forest Innovation Quarter. Construction will begin immediately with plans to be ready to welcome medical students in July 2016.

The medical education building is Wake Forest Baptists most significant capital improvement project reliant upon philanthropy in decades.

Wake Forest School of Medicines presence in Winston-Salem is a tribute to philanthropy, said Wake Forest Baptists Chief Executive Officer, John D. McConnell, M.D., and we owe our thanks to leaders like James A. Gray and Bowman Gray whose example continues to inspire us. Building upon that legacy, we embark upon this exciting component for the School, which is also contingent upon philanthropic leadership. We continue to look to our partners who have helped make an investment in the health of the community, the economic base of downtown Winston-Salem and the future of medicine and innovation in biomedical science and information technology in Wake Forest Innovation Quarter.

Hand in hand with our philanthropic efforts, the Medical Center is fortunate in that Building 60-3 is a historic property, which qualifies the project for Historic, New Markets and State Mill tax credits, McConnell added. These tax credits significantly lower the cost of this project and make it possible, but because those tax credits sunset on Dec. 31, 2014, timing is crucial. That is why we are starting immediately.

The timing of the opening of the medical education building will coincide with Wake Forest Baptist introducing one of the most advanced medical school curriculums in the country, and will allow medical students to prepare for real-life experiences in the most modern of settings available for clinics and exam rooms, complete with the new informatics and technologies commonly used in patient care today.

In addition to training in the most advanced environments for outpatient clinics, medical students and faculty will learn in small group learning spaces, an anatomy lab, clinical skills labs and patient simulation suites, while support services including a student lounge, kitchen, faculty offices and meeting spaces will enhance student life and mentoring opportunities.

Wake Forest School of Medicine Dean Edward Abraham, M.D., said the time has come to create a medical training facility that matches the schools reputation as providing one of the highest quality programs in the country.

Our medical schools present facilities have been the training ground for our students since 1969. They have served us well, but our model of patient care has dramatically changed since then. Medicine has fast-forwarded to the digital age with computer-guided imaging and surgical procedures, lasers instead of scalpels and electronic medical records that allow patients to look up their medical test results, speak to their doctors and make appointments from their laptops and cell phones, Abraham said.

We will soon be introducing a leading-edge medical education curriculum that will prepare our highly qualified students to become outstanding physicians, and thus we must have the appropriate facilities to accommodate current learning and teaching styles and space to grow.

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School of Medicine to build downtown

Medical magnet program at Jones facing changes

Juniors and seniors in Jones High School's Medical Arts Magnet program will soon have the option to work on one of several medical-assisting degrees at Valencia College while in high school under a plan the School Board is expected to approve Tuesday night.

Some would graduate high school with an associate's degree.

The move is part of an effort to revamp a program that has struggled to draw and retain students. The dual-enrollment option, if approved, would start next fall.

Ashley Williams switched from Jones' medical magnet to its International Baccalaureate program because she wanted a more well-rounded education.

"If we had that when I was there, I probably would have stayed in the medical magnet," said Williams, 18, who graduated from Jones in May and is now a freshman at Rollins College.

One of two medical magnets in Orange County's public high schools, the Jones program has 73 students, more than half of whom come from other high schools.

The Valencia partnership would allow Jones medical arts students to take college classes on their own campus, including basic and medical courses, said Scott Fritz, the district's chief academic officer. They could work toward certified nursing assistant, medical assistant or EKG tech associate's degrees.

The idea is based on a similar partnership already in place with Wekiva High School's Laser Photonics Academy magnet program. Students there are dual-enrolled at Valencia.

"I would like to see more students be able to come out with a dual degree," said Jones principal Valeria Maxwell. "That's going to just help prepare them for life."

Current students such as Charvette Walker, who decided she wanted a medical career at age 5, have a program with fewer options.

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Medical magnet program at Jones facing changes

Career-minded middle-schoolers check out West Boca High

Brianna Aviles is already in Loggers' Run Middle School's pre-medical choice academy.

She wants to be a plastic surgeon, so her next logical step would be the Academy of Medical Sciences at West Boca High School.

Brianna and her mother Robin were among hundreds of middle school students and parents who piled into the high school to check out the four career academies. They also include Drafting & Design, Information Technology and Culinary Arts.

"This is a great way to determine if this is what you want to do for the rest of your life," said Principal Mark Stenner, as he watched throngs of visitors cross the courtyard between the auditorium and the academy classrooms for an open house the evening of Dec. 2.

Academy openings could be as many as 50 each, and an independent firm chooses the students by a lottery system, Stenner said.

So even though Brianna's GPA is 4.0, she may not necessarily get in or get into an academy right away. Micayla Richardson, another Loggers' Run eighth-grader, is also looking at American Heritage School, she said walking into the school earlier.

The 800-seat auditorium was about three-quarters full, a smaller crowd than usual, Stenner said before the presentation. "A lot of kids know where they want to go," he added.

The School District of Palm Beach County had the 2014 Showcase of Schools at the South Florida Fairgrounds on Nov. 3 that highlighted 270 plus choice programs and career academies, according to the district.

And this wasn't the only open house held this time of year.

"The deadline to apply for one of the district's choice programs is Jan. 30, so schools are holding these open houses and giving tours so parents and students have a chance to learn more about what our public schools have to offer," according to Kathy Burstein, media relations specialist for the district.

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Career-minded middle-schoolers check out West Boca High

Louisville Program Improves Half-Century Staple for Teaching Medical Students

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Newswise LOUISVILLE, Ky. For more than 50 years, standardized patients have been a staple of medical school instruction. These individuals are trained in symptoms and problems associated with disease and act as patients to give medical students hands-on training in the practice of medicine.

Today, the University of Louisville School of Medicine has taken use of standardized patients (SPs) to a new level, allowing more students to achieve learning objectives in a compressed time period and learn more about managing the continuity of care for patients.

The Longitudinal Standardized Patient Project gives students a single SP to see throughout their two-year Introduction to Clinical Medicine course. In the course, students must successfully master the core patient history-taking, examination and communication skills they will need for their future training and ultimately, as practicing physicians.

In the program, each student only sees their patient, one of nine patient characters we have developed, in 19 different patient encounters, said Charles Kodner, M.D., director of the Introduction to Clinical Medicine course. This single SP enables the development of a continuity relationship, eliminating the need for the student to review the patients history with each encounter. Students gain time to focus on the purpose of the patient visit and the individual learning outcome they are expected to achieve.

In short, the Longitudinal Standardized Patient Project more closely mirrors what our students will see when they start caring for actual patients later in their training and once they become practicing physicians.

The ongoing student-SP relationship has strong benefits for the student, said Carrie Bohnert, director of the UofL Standardized Patient Program. Students begin to realize much earlier in the medical education that patients are real people with potentially complex personal and medical histories, she said. They are able to experience a doctor-patient relationship that has continuity something not otherwise available during the first two years of medical school.

An unexpected benefit has been the growing role of the SP as teacher as well. Our SPs have developed personal teaching relationships with their students and are able to identify subtle changes in student skill development or lack of development and other problems that might otherwise be missed without a strong continuity relationship, Bohnert said.

The program has been well-received, Kodner said. As we survey students both before and after the Longitudinal Standardized Patient Project, we have observed substantial increases in our students perceptions that the cases were realistic and that they could learn about medical problems and their patient as a person in the time available.

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Louisville Program Improves Half-Century Staple for Teaching Medical Students

No Increase in Patient Deaths or Hospital Readmissions Following Restrictions to Medical Residents' Hours

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Newswise PHILADELPHIA In the first year after the Accreditation Council for Graduate Medical Education (ACGME) reduced the number of continuous hours that residents can work, there was no change in the rate of death or readmission among hospitalized Medicare patients, according to a new study published in JAMA. The study was led by researchers at the Perelman School of Medicine at the University of Pennsylvania and The Childrens Hospital of Philadelphia.

There has been a lot of speculation about the effect of the 2011 ACGME duty hour reforms on patient outcomes, so we looked at death and readmission rates at the national level, said lead study author Mitesh S. Patel, MD, MBA, MS, assistant professor of Medicine and Health Care Management at Penn and an attending physician at the Philadelphia VA Medical Center. Some hoped that by shortening intern shifts from 30 hours to 16 hours, less fatigued residents would lead to less medical errors and improved patient outcomes. Yet, others were concerned that shorter shifts would increase patient handoffs and leave less time for education, thereby negatively affecting patient outcomes. These results show that in the first year after the reforms, neither was true.

In 2011, the ACGME implemented new restrictions in teaching hospitals across the United States, limiting the number of consecutive hours that residents can work. For first-year residents (interns), the rules cut the maximum number of consecutive work hours from 30 hours to 16. For all other residents, the maximum number of consecutive work hours was reduced from 30 hours to 24 (with an additional four hours for transitions of care and educational activities). The revisions did, however, maintain the 80 hour-per-week cap that was instituted in 2003, following decades in which residents routinely worked more than 100 hours a week.

This study examined nearly 6.4 million Medicare patient hospital admissions between July 2009 and June 2012. The patients were admitted for heart attack, stroke, gastrointestinal bleeding or congestive heart failure, or for general, orthopedic, or vascular surgery. The study authors evaluated 30-day mortality and readmission rates, using the ratio of residents to hospital beds as a measure of hospital teaching intensity in order to compare outcomes between more intensive and less intensive teaching hospitals. They found no relative changes in patient deaths or hospital readmissions during this time period.

Even though residents are working shorter shifts, these results should provide some confidence that in the first year after duty hour reforms there was no negative or positive associations with quality of care as measured by patient death and readmission, added Patel. In addition, the change in duty hours means that residents may have more time to sleep and balance their other personal and academic commitments.

The other Penn study authors include Kevin G. Volpp, MD, PhD, Dylan S. Small, PhD, Alexander S. Hill, BS, Orit Even-Shoshan, MS, Richard N. Ross, MS, Lisa Bellini, MD, Jingsan Zhu, MBA, and Jeffrey H. Silber, MD, PhD. The study was funded in part by a National Heart, Lung and Blood Institute grant (R01-HL094593). Patels work was supported by the Department of Veteran Affairs and the Robert Wood Johnson Foundation. Editors Note: Additional media resources for this study, including video, are available on the JAMA website.

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Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.

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No Increase in Patient Deaths or Hospital Readmissions Following Restrictions to Medical Residents' Hours

No increase in patient deaths or readmissions following restrictions to residents' hours

PUBLIC RELEASE DATE:

9-Dec-2014

Contact: Anna Duerr anna.duerr@uphs.upenn.edu 215-349-8369 University of Pennsylvania School of Medicine @PennMedNews

PHILADELPHIA - In the first year after the Accreditation Council for Graduate Medical Education (ACGME) reduced the number of continuous hours that residents can work, there was no change in the rate of death or readmission among hospitalized Medicare patients, according to a new study published in JAMA. The study was led by researchers at the Perelman School of Medicine at the University of Pennsylvania and The Children's Hospital of Philadelphia.

"There has been a lot of speculation about the effect of the 2011 ACGME duty hour reforms on patient outcomes, so we looked at death and readmission rates at the national level," said lead study author Mitesh S. Patel, MD, MBA, MS, assistant professor of Medicine and Health Care Management at Penn and an attending physician at the Philadelphia VA Medical Center. "Some hoped that by shortening intern shifts from 30 hours to 16 hours, less fatigued residents would lead to less medical errors and improved patient outcomes. Yet, others were concerned that shorter shifts would increase patient handoffs and leave less time for education, thereby negatively affecting patient outcomes. These results show that in the first year after the reforms, neither was true."

In 2011, the ACGME implemented new restrictions in teaching hospitals across the United States, limiting the number of consecutive hours that residents can work. For first-year residents (interns), the rules cut the maximum number of consecutive work hours from 30 hours to 16. For all other residents, the maximum number of consecutive work hours was reduced from 30 hours to 24 (with an additional four hours for transitions of care and educational activities). The revisions did, however, maintain the 80 hour-per-week cap that was instituted in 2003, following decades in which residents routinely worked more than 100 hours a week.

This study examined nearly 6.4 million Medicare patient hospital admissions between July 2009 and June 2012. The patients were admitted for heart attack, stroke, gastrointestinal bleeding or congestive heart failure, or for general, orthopedic, or vascular surgery. The study authors evaluated 30-day mortality and readmission rates, using the ratio of residents to hospital beds as a measure of hospital teaching intensity in order to compare outcomes between more intensive and less intensive teaching hospitals. They found no relative changes in patient deaths or hospital readmissions during this time period.

"Even though residents are working shorter shifts, these results should provide some confidence that in the first year after duty hour reforms there was no negative or positive associations with quality of care as measured by patient death and readmission," added Patel. "In addition, the change in duty hours means that residents may have more time to sleep and balance their other personal and academic commitments."

###

The other Penn study authors include Kevin G. Volpp, MD, PhD, Dylan S. Small, PhD, Alexander S. Hill, BS, Orit Even-Shoshan, MS, Richard N. Ross, MS, Lisa Bellini, MD, Jingsan Zhu, MBA, and Jeffrey H. Silber, MD, PhD. The study was funded in part by a National Heart, Lung and Blood Institute grant (R01-HL094593). Patel's work was supported by the Department of Veteran Affairs and the Robert Wood Johnson Foundation.

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No increase in patient deaths or readmissions following restrictions to residents' hours

Crewzing – #1 Liberty Walk Ferrari 458 Replica – San Francisco, Cars I Want In The Crew & More – Video


Crewzing - #1 Liberty Walk Ferrari 458 Replica - San Francisco, Cars I Want In The Crew More
What #39;s up guys welcome to episode 1 of Crewzing. This is my brand new series which is an equivalent to "Free Ride" but in The Crew. To kick it out, I take my Ferrari 458 Speciale (which I...

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Crewzing - #1 Liberty Walk Ferrari 458 Replica - San Francisco, Cars I Want In The Crew & More - Video

StarCraft 2: Wings of Liberty [Misin 10] Pualadas traperas [Logros en difcil] [HD] [1080p] – Video


StarCraft 2: Wings of Liberty [Misin 10] Pualadas traperas [Logros en difcil] [HD] [1080p]
Gameplay de la dcima misin del modo campaa de StarCraft II: Wings of Liberty. Misin 10: Pualadas traperas (Misiones de la rebelin). Planeta: Bel #39;Shir. Objetivo: Obtener gas terrazine...

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StarCraft 2: Wings of Liberty [Misin 10] Pualadas traperas [Logros en difcil] [HD] [1080p] - Video

2009 Jeep Liberty Sport Used Cars – Carrollton,TX – 2014-12-08 – Video


2009 Jeep Liberty Sport Used Cars - Carrollton,TX - 2014-12-08
See more details about this used car at http://texasautowarehouse.com/vehicle/5335694/2009-jeep-liberty-sport-suv-trade-in-low-miles-carrollton-tx-75006. This 2009 Jeep Liberty Sport with 58642...

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USFJ Chief of Staff discusses Liberty Policy for US service members in Japan (09Dec14) – Video


USFJ Chief of Staff discusses Liberty Policy for US service members in Japan (09Dec14)
The United States Forces Japan Chief of Staff, COL Cory Mendenhall discusses the new Liberty Policy on AFN Tokyo #39;s Morning Cruise Control.

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USFJ Chief of Staff discusses Liberty Policy for US service members in Japan (09Dec14) - Video