2010 Jeep Liberty for Brandon at Tameron Honda in Birmingham- Brandon Teneyck – Video

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2010 Jeep Liberty for Brandon at Tameron Honda in Birmingham- Brandon Teneyck
Visit us at http://www.tameronhonda.com to see our HUGE inventory of both new and used cars, check out our special programs, and great deals and coupons! Come by Tameron Honda in Birmingham, ...

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2010 Jeep Liberty for Brandon at Tameron Honda in Birmingham- Brandon Teneyck - Video

1916 Easter Rising – …beneath a Dublin Sky – Connolly Statue / Opposite Liberty Hall – Video

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1916 Easter Rising - ...beneath a Dublin Sky - Connolly Statue / Opposite Liberty Hall
Every Irish rebellion has generated its own collection of songs. At noon on the 24th of April 1916 the Easter Rising began - a defining moment in Irish history.This commemorative collection...

By: Dolphin Music Group

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1916 Easter Rising - ...beneath a Dublin Sky - Connolly Statue / Opposite Liberty Hall - Video

People's Liberty to spark change in OTR

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CINCINNATI People's Liberty is open for business.

The philanthropic laboratory unveiled its newly renovated office space Friday in the old Globe furniture building near Findlay Market in Over-the-Rhine.

"This is a big day in the life of People's Liberty," said CEO Eric Avner. "This is the real concrete beginning of our activities."

For People's Liberty, those activities all revolve around investing in people to show that philanthropy focused on individuals can change communities.

The organization announced its first two Haile Fellows late last year, awarding each a $100,000 cash prize and 12 months of working space in the Globe building. Its first gallery installment at the building will open Friday evening. And in the coming months it will be awarding project grants of up to $10,000 each, too.

Eric Avner, CEO of Peoples Liberty, led a tour through the building on March 27, 2015. Emily Maxwell | WCPO

The building renovation has allowed People's Liberty to invest in other important ways, too, Avner said. The Carol Ann and Ralph V. Haile, Jr./U.S. Bank Foundation one of the People's Liberty funders has spent about $3.6 million on the renovation. And the vast majority of the work on the project has gone to businesses located in or near Over-the-Rhine, Avner said.

Camp Washington-based Brush Factory was among them.

Owned by Rosie Kovacs and Hayes Shanesy, who live in Over-the-Rhine, Brush Factory designs and makes furniture for homes, offices, restaurants and retail spaces.

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People's Liberty to spark change in OTR

WILD ONES – "Show Me Islands" (Live in Austin, TX 2015) #JAMINTHEVAN – Video

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WILD ONES - "Show Me Islands" (Live in Austin, TX 2015) #JAMINTHEVAN
Wild Ones - "Show Me Islands" Live at the GQ Artist House in Austin, TX with Jam in the Van. Subscribe to Jam in the Van! http://bit.ly/subthejamvan GET THE AUDIO HERE: http://www.jaminthevan.c...

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WILD ONES - "Show Me Islands" (Live in Austin, TX 2015) #JAMINTHEVAN - Video

SAINT KITTS & NEVIS 6-2 TURKS & CAICOS ISLANDS 2018 FIFA World Cup Qualifiers – Goals – Video

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SAINT KITTS NEVIS 6-2 TURKS CAICOS ISLANDS 2018 FIFA World Cup Qualifiers - Goals
The two first goals are unfortunately missing. Second version with one less goal: http://youtu.be/9lufhRgLbHY First version with two less goals: http://youtu.be/6hR2-qHiBUU.

By: Krokomime

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SAINT KITTS & NEVIS 6-2 TURKS & CAICOS ISLANDS 2018 FIFA World Cup Qualifiers - Goals - Video

What if the severity of our seasonal influenza were related to our genetic background?

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While most of us recover from influenza after a week, it can be a very severe disease, and even fatal in rare cases, with no reason for physicians to have expected such an outcome. By analysing the genome of a little girl who contracted a severe form of influenza at the age of two and a half years, researchers at the Laboratory of Human Genetics of Infectious Diseases (a joint French-American international laboratory), which brings together researchers from Inserm, Paris Descartes University, and physicians from the Paris public hospitals (AP-HP; Necker Hospital for Sick Children), working at the Imagine Institute, and from The Rockefeller University in New York, have discovered that she has a genetic mutation, unknown until now, that causes a subtle dysfunction in her immune system. More generally, these results show that genetic mutations could be the root cause of some severe forms of influenza in children, and indicate in any event that immune mechanisms missing in this little girl are needed for protection against this virus in humans. These results are published in the journal Science.

Seasonal influenza is an acute viral infection caused by the influenza virus. It is characterised by high fever, headaches, sore muscles, etc. Apart from vaccination, there is no treatment for it other than symptomatic (pain) treatment. In most cases, patients recover after a week, but in more vulnerable people influenza can cause acute respiratory distress, which is potentially fatal.

The main known risk factors for severe forms of influenza are some acquired comorbidities, such as chronic lung disease. However, the cause of most fatal cases remains unexplained, especially in children.

The absence of cases of severe influenza in patients with known acquired immunodeficiencies, which usually increase susceptibility to infections, is also surprising.

Given these different observations, the researchers at Jean-Laurent Cassanova's and Laurent Abel's laboratory, in Paris and New York, therefore formulated a hypothesis whereby severe influenza in healthy children might be the result of genetic errors.

To test this hypothesis, they sequenced the entire genome of a 7-year-old child who had contracted a severe form of influenza (influenza A virus strain H1N1), requiring her admission to a paediatric intensive care unit in January 2011, at the age of two and a half years. At the time, she showed no other known pathology that might have suggested greater vulnerability to the virus than that of other children.

This analysis, combined with analysis of her parents' genomes, made it possible to show that the little girl had inherited a mutated allele of the gene encoding interferon regulatory factor (IRF7) from both of her parents. The latter is a transcription factor known to amplify the production of interferons in response to viral infection in mice and humans.

In contrast to her parents, in whom the mutation of a single allele of the gene is of no consequence, in the little girl, mutation of both alleles of the gene encoding IRF7 has led to its inactivation. The result: failure to produce interferons, disrupting her system of defence against influenza virus infection in a cascading manner.

By carrying out a comprehensive series of experiments on blood cells, particularly dendritic cells, and by generating lung cells from stem cells taken from the young girl, the researchers provided proof that the mutations observed in this little girl explain the development of severe influenza. Furthermore, this discovery demonstrates that interferon amplification dependent on IRF7 expression is needed for protection against influenza virus in humans. They now need to search for mutations in this or other genes in other children recruited following an episode of unexplained severe influenza.

Based on these initial observations, the researchers at Inserm believe that therapeutic strategies based on recombinant interferons, available in the pharmacopoeia, could help to combat severe forms of influenza in children.

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What if the severity of our seasonal influenza were related to our genetic background?