Psychedelics: LSD, Mushrooms, Salvia | Facts | Drug Policy …

Psychedelic drugs include LSD (acid), psilocybin mushrooms, mescaline (found in peyote), ibogaine, salvia, and DMT (found in ayahuasca). Psychedelic substances have been used for thousands of years for religious and therapeutic purposes.

In the 1950s and early 1960s, psychedelic drugs such as LSD were considered promising treatments for a broad range of psychological and psychiatric conditions. Tens of thousands of people were introduced to them in clinical studies, as an adjunct to psychotherapy, or as part of a religious or spiritual practice.

By the late 1960s, however, as millions of people experimented with them, psychedelics became symbols of youthful rebellion, social upheaval, and political dissent. By the early 1970s, the government had halted scientific research to evaluate their medical safety and efficacy. The ban persisted for decades, but has gradually been lifted over the past decade.

Today, there are dozens of studies taking place to evaluate the medical safety and efficacy of psychedelics, and the Supreme Court has ruled that psychedelics can be used as part of the practices of certain organized religions.

Facts

Sources:

Grinspoon, Lester and James B. Bakalar. 1997. Psychedelic Drugs Reconsidered. New York: The Lindesmith Center.

Grob, Charles and Roger Walsh, ed. Higher Wisdom: Eminent Elders Expore the Continuing Impact of Psychedelics. SUNY University of New York Press, 2005.

Stamets, Paul, Psilocybin Mushrooms of the World, Berkeley, CA: Ten Speed Press, 1996.

Stolaroff, Myron. The Secret Chief. Sarasota, FL: MAPS, 2006.

Strassman, R. J. 1984. Adverse Reactions to Psychedelic Drugs: A Review of the Literature. The Journal of Nervous and Mental Disease 172: 577-95.

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Psychedelics: LSD, Mushrooms, Salvia | Facts | Drug Policy ...

TZM – Mission Statement – The Zeitgeist Movement

As of June 2016, The Zeitgeist Movement has formed an official 501c3 non-profit, tax exempt entity to help administration. As has been suggested for years, this new aspect of TZM has been created to assist core administrative tasks and costs, allowing for greater project development. See Intro Video

The 8th Annual Global 'Zeitgeist Day' Symposium Promotes Sustainability, Global Unity, and a Post-Scarcity Society

The 2016 event, featuring prominent speakers and guests from around the world, will be held in Athens, Greece on Saturday, March 26th, 2016

Press Release

June 2015 "Zeitgeist founder, Peter Joseph, joins Jesse Ventura to discuss the concept of a resource-based economy. With all of Earths resources in decline, it is time to scientifically manage the ones we have left. In this brand new episode of Off the Grid, Peter Joseph talks about the benefits of moving away from a market economy toward one that is based on resource management." Watch Now

The Zeitgeist Movement Education project is now live! The aim of the project is for every chapter of TZM to initially try to go into just one school or university to promote/discuss sustainable values and practices with the next generation.

To find out more and to get involved in the project please visit the website at http://www.tzmeducation.org

http://www.tzmeducation.org

Great activist tool. This 2 DVD set contains the talks from The Zeitgeist Movement's flagship awareness event known as "Zeitgeist Day" (aka Zday). This DVD Set is from the 5th annual Main Event that was held in Los Angeles, CA on March 17th, 2013. 12 Lectures in 6 Hours. Go Here

The Zeitgeist Movement's new Orientation Guide "The Zeitgeist Movement Defined" has been released.

Read Book

THANK YOU FOR THE GREAT 2014 EVENTS!

Uniting the world through the power of art, the Zeitgeist Media Festival is back for its fourth annual main event. Occurring at The Federal in North Hollywood, Saturday, October 4th, 2014 from 6pm-11pm, this not-for-profit activist arts festival features live music, comedy, short films, spoken word and more.

More Info/Press Kit

3rd Annual News Coverage

WATCH INTERVIEW

Peter Joseph exclusive interview with Abby Martin of "Breaking The Set" on Russia Today.

Economic Calculation in a Natural Law/Resource-Based Economy, Nov. 12th 2013

Watch Video

Thank you TZM Germany for a great event.

Published on Mar 14, 2013 "This week, Cenk Uygur sits down with Peter Joseph, founder of the Zeitgeist movement. The Zeitgeist movement's goal is to create global sustainability by changing established social systems. Can people save the world by changing socially? Is the market economy responsible for corruption, and is it serving its original purpose? Does the market economy leave room for true freewill, and is it truly possible to shed ourselves of material goods?

Free TZM Global Show Archives: Free Archive

Huge Thanks to our dedicated Chapters Coordinators for this helpful contribution!

OFFICIAL TZM CHAPTERS WEBSITE

NEW CHAPTERS GUIDE

Founded in 2008, The Zeitgeist Movement is a sustainability advocacy organization, which conducts community based activism and awareness actions through a network of global/regional chapters, project teams, annual events, media and charity work.

The movement's principle focus includes the recognition that the majority of the social problems that plague the human species at this time are not the sole result of some institutional corruption, absolute scarcity, a political policy, a flaw of "human nature" or other commonly held assumptions of causality. Rather, the movement recognizes that issues such as poverty, corruption, pollution, homelessness, war, starvation and the like appear to be "symptoms" born out of an outdated social structure.

While intermediate reform steps and temporal community support are of interest to the movement, the defining goal is the installation of a new socioeconomic model based upon technically responsible resource management, allocation and design through what would be considered the scientific method of reasoning problems and finding optimized solutions.

This Natural Law/Resource-Based Economy" (NLRBE) is about taking a direct technical approach to social management as opposed to a monetary or even political one. It is about updating the workings of society to the most advanced and proven methods known, leaving behind the damaging consequences and limiting inhibitions which are generated by our current system of monetary exchange, profit, business and other structural and motivational issues.

The movement is loyal to a train of thought, not figures or institutions. The view held is that through the use of socially targeted research and tested understandings in science and technology, we are now able to logically arrive at societal applications that could be profoundly more effective in meeting the needs of the human population, increasing public health. There is little reason to assume war, poverty, most crime and many other monetarily-based scarcity effects common in our current model cannot be resolved over time. The range of the movement's activism and awareness campaigns extend from short to long term, with methods based explicitly on non-violent methods of communication.

The Zeitgeist Movement has no allegiance to any country or traditional political platforms. It views the world as a single system and the human species as a single family and recognizes that all countries must disarm and learn to share resources and ideas if we expect to survive in the long run. Hence, the solutions arrived at and promoted are in the interest to help everyone on Earth, not a select group.

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TZM - Mission Statement - The Zeitgeist Movement

Campaign for the Abolition of Terrier Work – Badger Baiting

Every year, hundreds of badgers meet a horrific death in the name of 'sport' in the UK at the hands of terriermen. Many of those who have been caught digging into badger setts have used the excuse that they were after foxes - and many have escaped prosecution by so doing.

More than 10,000 are caught, tortured and killed in the UK each year by huntsmen with terriers - with almost a third of these illegal acts being carried out in Wales. Alarmingly, this figure is rising constantly. Terry Spamer, a former RSPCA inspector, believes that there are around 2,000 people involved in badger baiting currently. However, only around three people are caught and convicted of badger baiting each year, while the majority carry on breaking the law.

Badger Baiting was made illegal in 1835 and is currently an offence under the Protection of Animals Act 1911, but it has never died out. Sadly, it is the badger's tenacity, its apparent ability to absorb almost any punishment and still go on fighting, which has made it a target for people who get their kicks from inflicting cruelty upon animals, even today.

Small terriers, such as Lakelands, Patterdales, sometimes Jack Russells or a cross-breed are sent down into a badger sett to locate a badger and hold it at bay. The men then dig their way down to their quarry and drag the badger out of the sett. Many diggers attach a radio transmitter to the dog's collar before sending it below ground then all they have to do is use a radio receiver/locater to determine the exact location of the dog.

There are essentially two types of badger baiters. The first who do it just for the pleasure of killing the badger on the spot and no money is involved. If it's lucky the badger will be shot but usually the men will set their snarling terriers on the badger and watch it suffer a long and agonising death stabbing it with shovels for good measure. At times, the dogs and the badgers may die when the sett collapses and suffocates them. (Many badger groups have fortified their local setts with concrete to protect the badgers.)

The second type of badger baiting involves gambling where large sums of money can change hands. The badger is dug out of the sett in the manner described above and then it is put in a bag and taken away to be baited later on. The badger is taken somewhere quiet for example a barn, shed or cellar and placed into a makeshift arena, a ring or pit, from which it cannot escape. Dogs are then set upon it. Even if the badger is lucky enough to get the better of one dog, the owner may hit or otherwise injure the badger in order to 'protect his pet'. Ultimately, no matter how well it tries to defend itself, the badger's fate is sealed. The badger, through injury and exhaustion, will not be able fight any longer. The baiters will then kill the badger usually by clubbing or shooting it. Gambling is always involved and a winning dog's value will rise - along with the price of its puppies. An anonymous letter received by Badger Watch & Rescue Dyfed states that badgers are being caught and sold for about 500 for baiting.

Badgers are shy and peaceful animals and not normally aggressive, but will defend themselves if cornered or provoked. A badger has great strength and a blow from one of its vicious claws can do serious harm. Many dogs seriously injured during badger digging and baiting go untreated as their owners are more concerned vets will become suspicious of the owner's illegal activity.

Badger baiting with 7 dogs. Its back legs are held by a chain to prevent escape. The animals multilated head, minus nose and lower jaw, finished up mounted on a plaque.

It's not just 'rogue' terriermen who consider badger baiting a perfectly respectable pastime. For example, Bob Lawrence writing in Countrymans Weekly, 4 March 1994, comment:

"It is sad that a large proportion of the sporting community has taken to condemning badger digging. Perhaps this condemnation is a ploy to throw a smokescreen into the antis. At one time it was regarded as a true country sport and was reported in magazines like The Field. Indeed that illustrious publication was responsible for the publishing of an excellent little book entitled Working Terriers, Badgers and Badger Digging written by H H King. Anyone who has a chance to read it should do so as it gives an excellent insight into a real sporting pastime.

"Badger digging, when conducted in the proper manner by people who respected the quarry and the gallant little dogs used to dig them, was a perfectly respectable sport."

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Campaign for the Abolition of Terrier Work - Badger Baiting

Transhumanism | Foreign Policy

For the last several decades, a strange liberation movement has grown within the developed world. Its crusaders aim much higher than civil rights campaigners, feminists, or gay-rights advocates. They want nothing less than to liberate the human race from its biological constraints. As "transhumanists" see it, humans must wrest their biological destiny from evolutions blind process of random variation and adaptation and move to the next stage as a species.

It is tempting to dismiss transhumanists as some sort of odd cult, nothing more than science fiction taken too seriously: Witness their over-the-top Web sites and recent press releases ("Cyborg Thinkers to Address Humanitys Future," proclaims one). The plans of some transhumanists to freeze themselves cryogenically in hopes of being revived in a future age seem only to confirm the movements place on the intellectual fringe.

But is the fundamental tenet of transhumanism that we will someday use biotechnology to make ourselves stronger, smarter, less prone to violence, and longer-lived really so outlandish? Transhumanism of a sort is implicit in much of the research agenda of contemporary biomedicine. The new procedures and technologies emerging from research laboratories and hospitals whether mood-altering drugs, substances to boost muscle mass or selectively erase memory, prenatal genetic screening, or gene therapy can as easily be used to "enhance" the species as to ease or ameliorate illness.

Although the rapid advances in biotechnology often leave us vaguely uncomfortable, the intellectual or moral threat they represent is not always easy to identify. The human race, after all, is a pretty sorry mess, with our stubborn diseases, physical limitations, and short lives. Throw in humanitys jealousies, violence, and constant anxieties, and the transhumanist project begins to look downright reasonable. If it were technologically possible, why wouldnt we want to transcend our current species? The seeming reasonableness of the project, particularly when considered in small increments, is part of its danger. Society is unlikely to fall suddenly under the spell of the transhumanist worldview. But it is very possible that we will nibble at biotechnologys tempting offerings without realizing that they come at a frightful moral cost.

The first victim of transhumanism might be equality. The U.S. Declaration of Independence says that "all men are created equal," and the most serious political fights in the history of the United States have been over who qualifies as fully human. Women and blacks did not make the cut in 1776 when Thomas Jefferson penned the declaration. Slowly and painfully, advanced societies have realized that simply being human entitles a person to political and legal equality. In effect, we have drawn a red line around the human being and said that it is sacrosanct.

Underlying this idea of the equality of rights is the belief that we all possess a human essence that dwarfs manifest differences in skin color, beauty, and even intelligence. This essence, and the view that individuals therefore have inherent value, is at the heart of political liberalism. But modifying that essence is the core of the transhumanist project. If we start transforming ourselves into something superior, what rights will these enhanced creatures claim, and what rights will they possess when compared to those left behind? If some move ahead, can anyone afford not to follow? These questions are troubling enough within rich, developed societies. Add in the implications for citizens of the worlds poorest countries for whom biotechnologys marvels likely will be out of reach and the threat to the idea of equality becomes even more menacing.

Transhumanisms advocates think they understand what constitutes a good human being, and they are happy to leave behind the limited, mortal, natural beings they see around them in favor of something better. But do they really comprehend ultimate human goods? For all our obvious faults, we humans are miraculously complex products of a long evolutionary process products whose whole is much more than the sum of our parts. Our good characteristics are intimately connected to our bad ones: If we werent violent and aggressive, we wouldnt be able to defend ourselves; if we didnt have feelings of exclusivity, we wouldnt be loyal to those close to us; if we never felt jealousy, we would also never feel love. Even our mortality plays a critical function in allowing our species as a whole to survive and adapt (and transhumanists are just about the last group Id like to see live forever). Modifying any one of our key characteristics inevitably entails modifying a complex, interlinked package of traits, and we will never be able to anticipate the ultimate outcome.

Nobody knows what technological possibilities will emerge for human self-modification. But we can already see the stirrings of Promethean desires in how we prescribe drugs to alter the behavior and personalities of our children. The environmental movement has taught us humility and respect for the integrity of nonhuman nature. We need a similar humility concerning our human nature. If we do not develop it soon, we may unwittingly invite the transhumanists to deface humanity with their genetic bulldozers and psychotropic shopping malls.

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Transhumanism | Foreign Policy

WHAT IS TRANSHUMANISM? – Nick Bostrom

Over the past few years, a new paradigm for thinking about humankind's future has begun to take shape among some leading computer scientists, neuroscientists, nanotechnologists and researchers at the forefront of technological development. The new paradigm rejects a crucial assumption that is implicit in both traditional futurology and practically all of today's political thinking. This is the assumption that the "human condition" is at root a constant. Present-day processes can be fine-tuned; wealth can be increased and redistributed; tools can be developed and refined; culture can change, sometimes drastically; but human nature itself is not up for grabs.

This assumption no longer holds true. Arguably it has never been true. Such innovations as speech, written language, printing, engines, modern medicine and computers have had a profound impact not just on how people live their lives, but on who and what they are. Compared to what might happen in the next few decades, these changes may have been slow and even relatively tame. But note that even a single additional innovation as important as any of the above would be enough to invalidate orthodox projections of the future of our world.

"Transhumanism" has gained currency as the name for a new way of thinking that challenges the premise that the human condition is and will remain essentially unalterable. Clearing away that mental block allows one to see a dazzling landscape of radical possibilities, ranging from unlimited bliss to the extinction of intelligent life. In general, the future by present lights looks very weird - but perhaps very wonderful - indeed.

Some of the possibilities that you will no doubt hear discussed in the coming years are quite extreme and sound like science-fiction. Consider the following:

These prospects might seem remote. Yet transhumanists think there is reason to believe that they might not be so far off as is commonly supposed. The Technology Postulate denotes the hypothesis that several of the items listed, or other changes that are equally profound, will become feasible within, say, seventy years (possibly much sooner). This is the antithesis of the assumption that the human condition is a constant. The Technology Postulate is often presupposed in transhumanist discussion. But it is not an article of blind faith; it's a falsifiable hypothesis that is argued for on specific scientific and technological grounds.

If we come to believe that there are good grounds for believing that the Technology Postulate is true, what consequences does that have for how we perceive the world and for how we spend our time? Once we start reflecting on the matter and become aware of its ramifications, the implications are profound.

From this awareness springs the transhumanist philosophy -- and "movement". For transhumanism is more than just an abstract belief that we are about to transcend our biological limitations by means of technology; it is also an attempt to re-evaluate the entire human predicament as traditionally conceived. And it is a bid to take a far-sighted and constructive approach to our new situation. A primary task is to provoke the widest possible discussion of these topics and to promote a better public understanding. The set of skills and competencies that are needed to drive the transhumanist agenda extend far beyond those of computer scientists, neuroscientists, software-designers and other high-tech gurus. Transhumanism is not just for brains accustomed to hard-core futurism. It should be a concern for our whole society.

It is extremely hard to anticipate the long-term consequences of our present actions. But rather than sticking our heads in the sand, transhumanists reckon we should at least try to plan for them as best we can. In doing so, it becomes necessary to confront some of the notorious "big questions" about the structure of the world and the role and prospects of sentience within it. Doing so requires delving into a number of different scientific disciplines as well as tackling hard philosophical problems.

While the wider perspective and the bigger questions are essential to transhumanism, that does not mean that transhumanists do not take an intense interest in what goes in our world today. On the contrary! Recent topical themes that have been the subject of wide and lively debate in transhumanist forums include such diverse issues as cloning; proliferation of weapons of mass-destruction; neuro/chip interfaces; psychological tools such as critical thinking skills, NLP, and memetics; processor technology and Moore's law; gender roles and sexuality; neural networks and neuromorphic engineering; life-extension techniques such as caloric restriction; PET, MRI and other brain-scanning methods; evidence (?) for life on Mars; transhumanist fiction and films; quantum cryptography and "teleportation"; the Digital Citizen; atomic force microscopy as a possible enabling technology for nanotechnology; electronic commerce.... Not all participants are equally at home in all of these fields, of course, but many like the experience of taking part in a joint exploration of unfamiliar ideas, facts and standpoints.

An important transhumanist goal is to improve the functioning of human society as an epistemic community. In addition to trying to figure out what is happening, we can try to figure out ways of making ourselves better at figuring out what is happening. We can create institutions that increase the efficiency of the academic- and other knowledge-communities. More and more people are gaining access to the Internet. Programmers, software designers, IT consultants and others are involved in projects that are constantly increasing the quality and quantity of advantages of being connected. Hypertext publishing and the collaborative information filtering paradigm have the potential to accelerate the propagation of valuable information and aid the demolition of what transpire to be misconceptions and crackpot claims. The people working in information technology are only the latest reinforcement to the body of educators, scientists, humanists, teachers and responsible journalists who have been striving throughout the ages to decrease ignorance and make humankind as a whole more rational.

One simple but brilliant idea, developed by Robin Hanson, is that we create a market of "idea futures". Basically, this means that it would be possible to place bets on all sorts of claims about controversial scientific and technological issues. One of the many benefits of such an institution is that it would provide policy-makers and others with consensus estimates of the probabilities of uncertain hypotheses about projected future events, such as when a certain technological breakthrough will occur. It would also offer a decentralized way of providing financial incentives for people to make an effort to be right in what they think. And it could promote intellectual sincerity in that persons making strong claims would be encouraged to put their money where their mouth is. At present, the idea is embodied in an experimental set-up, the Foresight Exchange, where people can stake "credibility points" on a variety of claims. But for its potential advantages to materialize, a market has to be created that deals in real money and is as integrated in the established economic structure as are current stock exchanges. (Present anti-gambling regulations are one impediment to this; in many countries betting on anything other than sport and horses is prohibited.)

The transhumanist outlook can appear cold and alien at first. Many people are frightened by the rapid changes they are witnessing and respond with denial or by calling for bans on new technologies. It's worth recalling how pain relief at childbirth through the use of anesthetics was once deplored as unnatural. More recently, the idea of "test-tube babies" has been viewed with abhorrence. Genetic engineering is widely seen as interfering with God's designs. Right now, the biggest moral panic is cloning. We have today a whole breed of well-meaning biofundamentalists, religious leaders and so-called ethical experts who see it as their duty to protect us from whatever "unnatural" possibilities that don't fit into their preconceived world-view. The transhumanist philosophy is a positive alternative to this ban-the-new approach to coping with a changing world. Instead of rejecting the unprecedented opportunities on offer, it invites us to embrace them as vigorously as we can. Transhumanists view technological progress as a joint human effort to invent new tools that we can use to reshape the human condition and overcome our biological limitations, making it possible for those who so want to become "post-humans". Whether the tools are "natural" or "unnatural" is entirely irrelevant.

Transhumanism is not a philosophy with a fixed set of dogmas. What distinguishes transhumanists, in addition to their broadly technophiliac values, is the sort of problems they explore. These include subject matter as far-reaching as the future of intelligent life, as well as much more narrow questions about present-day scientific, technological or social developments. In addressing these problems, transhumanists aim to take a fact-driven, scientific, problem-solving approach. They also make a point of challenging holy cows and questioning purported impossibilities. No principle is beyond doubt, not the necessity of death, not our confinement to the finite resources of planet Earth, not even transhumanism itself is held to be too good for constant critical reassessment. The ideology is meant to evolve and be reshaped as we move along, in response to new experiences and new challenges. Transhumanists are prepared to be shown wrong and to learn from their mistakes.

Transhumanism can also be very practical and down-to-earth. Many transhumanists find ways of applying their philosophy to their own lives, ranging from the use of diet and exercise to improve health and life-expectancy; to signing up for cryonic suspension; creating transhumanist art; using clinical drugs to adjust parameters of mood and personality; applying various psychological self-improvement techniques; and in general taking steps to live richer and more responsible lives. An empowering mind-set that is common among transhumanists is dynamic optimism: the attitude that desirable results can in general be accomplished, but only through hard effort and smart choices.

Are you a transhumanist? If so, then you can look forward to increasingly seeing your own views reflected in the media and in society. For it is clear that transhumanism is an idea whose time has come.

_______________

Postscript

(September, 2001)

This article was first published in 1998. Since then things have developed, both technologically (of course) but also philosophically. I want to say just a few words about the main changes in my own thinking that have occurred over the past years.

1. When the first version was written, the main challenge was to make people aware of potential developments that the article discusses. That has been happening increasingly. Although there is still a long way to go, the focus for me has shifted to getting into the details, taking more account of the obstacles and downsides, and trying to develop a more sensitive treatment of the complex issues involved.

2. Many people are scared by transhumanism. While some of the fear is based on misconceptions, a significant part of it reflects a legitimate concern that in the process of pursuing technological improvements, we could risk losing some of the things that we regard as most valuable. The challenge, therefore, is to be sensitive to our fundamental values and to find a vision and a roadmap that will not lead to their disappearance but rather their enhancement (albeit, perhaps, in a transposed form). We must emphasize that what we should strive for is not technology instead of humanity, but technology for humanity.

3. In addition to the somewhat intangible risk that we create a utopia where we have forgotten to include the things we care about most, there are various concrete risks of technology being used destructively, either by accident or malicious intent (consider e.g. the risks from nanotechnology referred to above). Planning to minimize these risks is a central concern.

4. A fundamental fact about us humans is that we care about how we relate to each other. Love, affection, envy, and friendships are such important parts of who and what we are that they cannot be left out of the equation. And there are no easy technological fixes to these issues. For example, maybe future technology could give you the illusion and the feeling of being loved. But maybe what you really want is to actually be loved and not just by some custom-made lovebot, but by this currently existing human being that you have given your heart to. The best technology could do is to help you create the conditions under which your love could flourish and grow indefinitely, unencumbered by the erosive forces of current material and psychological conditions.

_______________

ACKNOWLEDGEMENTS

Im grateful to Anders Sandberg and David Pearce for comments on an earlier draft.

About Nick Bostrom

Dr. Nick Bostrom received his Ph.D. in philosophy from the London School of Economics in the year 2000. He is currently a Lecturer at the Department of Philosophy at Yale University. A founder of the World Transhumanist Association, he is the author of numerous publications in the foundations of probability theory, ethics, transhumanism, and philosophy of science, including the book Anthropic Bias: Observation Selection Effects in Science and Philosophy (Routledge, New York), which is due out in April 2002. For more information, see: http://www.nickbostrom.com

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WHAT IS TRANSHUMANISM? - Nick Bostrom

Rational egoism – Wikipedia

Rational egoism (also called rational selfishness) is the principle that an action is rational if and only if it maximizes one's self-interest.[1] The view is a normative form of egoism. It is distinct from psychological egoism (according to which people are motivated only to act in their own self-interest) and ethical egoism (that moral agents ought only to do what is in their own self-interest).[2]

Rational egoism was embodied by Russian author Nikolay Chernyshevsky in the 1863 book What Is to Be Done?.[3] Chernyshevsky's standpoint was ultimately socialistic, and was criticised by Fyodor Dostoyevsky in the 1864 book Notes from Underground.[4][5]

English philosopher Henry Sidgwick discussed rational egoism in his book The Methods of Ethics, first published in 1872.[6] A method of ethics is "any rational procedure by which we determine what individual human beings 'ought' or what it is 'right' for them to do, or seek to realize by voluntary action".[7] Sidgwick considers three such procedures, namely, rational egoism, dogmatic intuitionism, and utilitarianism. Rational egoism is the view that, if rational, "an agent regards quantity of consequent pleasure and pain to himself alone important in choosing between alternatives of action; and seeks always the greatest attainable surplus of pleasure over pain".[8]

Sidgwick found it difficult to find any persuasive reason for preferring rational egoism over utilitarianism. Although utilitarianism can be provided with a rational basis and reconciled with the morality of common sense, rational egoism appears to be an equally plausible doctrine regarding what we have most reason to do. Thus we must "admit an ultimate and fundamental contradiction in our apparent intuitions of what is Reasonable in conduct; and from this admission it would seem to follow that the apparently intuitive operation of Practical Reason, manifested in these contradictory judgments, is after all illusory".[9]

Two objections to rational egoism are given by the English philosopher Derek Parfit, who discusses the theory at length in Reasons and Persons.[10] First, from the rational egoist point of view, it is rational to contribute to a pension scheme now, even though this is detrimental to one's present interests (which are to spend the money now). But it seems equally reasonable to maximize one's interests now, given that one's reasons are not only relative to him, but to him as he is now (and not his future self, who is argued to be a "different" person). Parfit also argues that since the connections between the present mental state and the mental state of one's future self may decrease, it is not plausible to claim that one should be indifferent between one's present and future self.

The author and philosopher Ayn Rand also discusses a theory that she called 'rational egoism'. She holds that it is both irrational and immoral to act against one's self-interest.[11] Thus, her view is a conjunction of both rational egoism (in the standard sense) and ethical egoism, because according to Objectivist philosophy, egoism cannot be properly justified without an epistemology based on reason:

Her book The Virtue of Selfishness (1964) explains the concept of rational egoism in depth. According to Rand, a rational man holds his own life as his highest value, rationality as his highest virtue, and his happiness as the final purpose of his life.

Conversely, Rand was sharply critical of the ethical doctrine of altruism:

Do not confuse altruism with kindness, good will or respect for the rights of others. These are not primaries, but consequences, which, in fact, altruism makes impossible. The irreducible primary of altruism, the basic absolute is self-sacrificewhich means self-immolation, self-abnegation, self-denial self-destructionwhich means the self as a standard of evil, the selfless as a standard of the good.

Do not hide behind such superficialities as whether you should or should not give a dime to a beggar. This is not the issue. The issue is whether you do or do not have the right to exist without giving him that dime. The issue is whether you must keep buying your life, dime by dime, from any beggar who might choose to approach you. The issue is whether the need of others is the first mortgage on your life and the moral purpose of your existence. The issue is whether man is to be regarded as a sacrificial animal. Any man of self-esteem will answer: No. Altruism says: Yes."[12]

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Rational egoism - Wikipedia

An Introduction to LaVeyan Satanism and the Church of Satan

By Catherine Beyer

Updated January 16, 2016.

LaVeyan Satanism is one of several distinct religions identifying itself as Satanic. Followers are atheists who stress dependence on the self rather than reliance on any outside power. It encourages individualism, hedonism, materialism, ego, personal initiative, self-worth and self-determinism.

To the LaVeyan Satanist, Satan is a myth, just like God and other deities. Satan is also, however, incredibly symbolic, representing all of those things within our natures that outsiders might tell us is dirty and unacceptable. The chant of Hail Satan! is really saying Hail me! It exults the self and rejects the self-denying lessons of society. Finally, Satan represents rebellion, just as Satan rebelled against God in Christianity. Identifying oneself as a Satanist is to go against expectations, cultural norms, and religious creeds.

Anton LaVey officially formed the church of Satan on the night of April 30-May 1, 1966 and published the Satanic Bible in 1969.

The Church of Satan admits that early rituals were mostly mockeries of Christian ritual and reenactments of Christian folklore concerning the supposed behavior of Satanists: upside down crosses, reading the Lords Prayer backward, using a nude woman as an altar, etc. However, as the Church of Satan evolved it solidified its own specific messages and tailored its rituals around those messages.

Because Satanism celebrates the self, ones own birthday in held as the most important holiday. Satanists also sometimes celebrate the nights of Walpurgisnacht (April 30-May 1) and Halloween (October 31-November 1), because these days have been traditionally associated with Satanists through witchcraft lore.

Satanism has been routinely accused of numerous onerous practices, generally without evidence. There is a common mistaken belief that because Satanists believe in serving themselves first that they become antisocial or even psychopathic. In truth, responsibility is a major tenet of Satanism. Humans have the right to do as they choose and should feel free to pursue their own happiness. However, this does not render them immune from consequences. Taking control of ones life includes being responsible about it. Among the things LaVey explicitly condemned:

In the 1980s, rumors and accusations abounded about supposedly Satanic individuals ritually abusing children. Many of those suspected worked as teachers or day care workers. After lengthy investigations, it was concluded that not only were the accused innocent, but that the abuses never even happened. In addition, suspects were not even associated with Satanic practice. The Satanic Panic is a modern day example of the power of mass hysteria.

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An Introduction to LaVeyan Satanism and the Church of Satan

Nihilism | Meaningness

Nihilism holds that there is no meaning or value anywhere. Questions about purpose, ethics, and sacredness are unanswerable because they are meaningless. You might as well ask about the sleep habits of colorless green ideas as about the meaning of life.

Nihilism is a mirror image of eternalismthe stance that everything is meaningful. (For an introduction, see Preview: eternalism and nihilism.) However, the two stances are not simply opposites; they share fundamental metaphysical assumptions.

Eternalism and nihilism both fail to recognize that nebulosity and pattern are inseparable. Therefore they suppose that real meaning would be absolutely patterned: perfectly definite and certain, unchanging and objective. This is their shared metaphysical error.

Eternalism insists that meaning really is like that. That is its second metaphysical error. Nihilism observes, accurately, that no such meaning is possible. This corrects the second error. However, because nihilism shares the first error, it concludes that meaning is impossible, period. This is also wrong; nebulous meanings are real, for any reasonable definition of real.

Nihilism is attractive to those who have explicitly recognized, understood, and rejected eternalisms second error: belief in ultimate meaning. That is not easy. Nihilism is, therefore, the more intelligent stance. Or, at least, its a stance that tends to be adopted more often by more intelligent people. (Its even more dysfunctional than eternalism, so we could also call it less intelligent.)

While most people are committed, however waveringly, to eternalism, only a few commit to nihilism. In denying all meaning, nihilism is wildly implausible. Only a few sociopaths, intellectuals, and depressives try to maintain it.

Well see, though, that almost everyone adopts the nihilistic stance at times, without noticing. When the complete stance is unknown, nihilism seems like the only possible defense against the harmful lies of eternalism. (Just as eternalism seems like the only possible salvation from the harmful lies of nihilism.)

Even if you are relatively immune to nihilism, its important to understand as a prototype. Many other confused stances are modified or limited forms of nihilism. They reject particular types of meanings, rather than rejecting all meaningfulness. That makes their distortions, harms, and emotional dynamics similar to nihilisms.

The first page in this section discusses several obstacles you must overcome to even get to nihilism. The main one is the obviousness of meaning. Even before that, you have to let go of the hope that eternalism can somehow be made to work. There are also strong social and cultural taboos against nihilism. Finally, nihilism has nasty psychological side-effects that make you miserable.

The second page explains briefly what it would mean to accomplish nihilism: a state of total apathy. This would, theoretically, end suffering (which is one reason nihilism is attractive). Its probably impossible, although some religious systems seem to advocate it.

Most of my discussion of nihilism concerns its emotional dynamics. I begin with an analogy: eternalism is like one of those email scams that promises you millions of dollars in exchange for help getting money out of Nigeria. If you fall for that, catastrophic financial loss ensues.

Nihilism entails a similar catastrophic loss: the loss of meaning. The next page gives an overview of our psychological reactions to that loss: rage, intellectual argument, depression, and anxiety. Each gets its own, more detailed page.

In addition, I address the content of nihilistic intellectualization. This is a collection of reasons for rejecting obvious meanings as not really meaningful. They are supposedly the wrong kind of meaning; not ultimate, not objective, not eternal, not inherent, or not higher. So what? These arguments are bogus and nonsensical. They usually conceal a hidden motivation: the issue is not qualitative (the wrong kind of meaning) but quantitative (available meanings seem inadequately compelling). This is a psychological and practical problem, not a philosophical one, so psychological and practical methods may help.

The antidotes to nihilism are partly intellectual: realizing why its incorrect and harmful. Mainly, though, antidotes restore meaningfulness, by making it more powerful, more obvious, more compelling, more enjoyable.

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Nihilism | Meaningness

EXCLUSIVE NSA Architect: Agency Has ALL of Clintons …

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Speaking as an analyst, Binney raised the possibility that the hack of the Democratic National Committees server was done not by Russia but by a disgruntled U.S. intelligence worker concerned about Clintons compromise of national security secrets via her personal email use.

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Binney was an architect of the NSAs surveillance program. He became a famed whistleblower when he resigned on October 31, 2001, after spending more than 30 years with the agency.

He was speaking on this reporters Sunday radio program, Aaron Klein Investigative Radio, broadcast on New Yorks AM 970 The Answer and Philadelphias NewsTalk 990 AM.

Binney referenced testimony before the Senate Judiciary Committee in March 2011 by then-FBI Director Robert S. Mueller in which Meuller spoke of the FBIs ability to access various secretive databases to track down known and suspected terrorists.

Stated Binney: Now what he (Mueller) is talking about is going into the NSA database, which is shown of course in the (Edward) Snowden material released, which shows a direct access into the NSA database by the FBI and the CIA. Which there is no oversight of by the way. So that means that NSA and a number of agencies in the U.S. government also have those emails.

So if the FBI really wanted them they can go into that database and get them right now, he stated of Clintons emails as well as DNC emails.

Asked point blank if he believed the NSA has copies of all of Clintons emails, including the deleted correspondence, Binney replied in the affirmative.

Yes, he responded. That would be my point. They have them all and the FBI can get them right there.

Listen to the full interview here:

Binney surmised that the hack of the DNC could have been coordinated by someone inside the U.S. intelligence community angry over Clintons compromise of national security data with her email use.

And the other point is that Hillary, according to an article published by the Observer in March of this year, has a problem with NSA because she compromised Gamma material. Now that is the most sensitive material at NSA. And so there were a number of NSA officials complaining to the press or to the people who wrote the article that she did that. She lifted the material that was in her emails directly out of Gamma reporting. That is a direct compromise of the most sensitive material at the NSA. So shes got a real problem there. So there are many people who have problems with what she has done in the past. So I dont necessarily look at the Russians as the only one(s) who got into those emails.

The Observer defined the GAMMA classification:

GAMMA compartment, which is an NSA handling caveat that is applied to extraordinarily sensitive information (for instance, decrypted conversations between top foreign leadership, as this was).

Aaron Klein is Breitbarts Jerusalem bureau chief and senior investigative reporter. He is a New York Times bestselling author and hosts the popular weekend talk radio program, Aaron Klein Investigative Radio. Follow him onTwitter @AaronKleinShow.Follow him onFacebook.

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EXCLUSIVE NSA Architect: Agency Has ALL of Clintons ...

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What Is Bitcoin Cryptocurrency? Webopedia Definition

Main TERM B

By Vangie Beal

Bitcoin is a digital payment currency that utilizes cryptocurrency (a digital medium of exchange) and peer-to-peer (P2P) technology to create and manage monetary transactions as opposed to a central authority. The open source Bitcoin P2P network creates the bitcoins and manages all the bitcoin transactions.

Often referred to as "cash for the Internet," Bitcoin is one of several popular digital payment currencies along with Litecoin, Peercoin and Namecoin. When the word Bitcoin is capitalized, it usually refers to the software and systems used for bitcoin (in lowercase it means the actual currency).

Bitcoin is considered the biggest cryptocurrency. It was first introduced in 2009 and is the most widely-traded cryptocurrency. Bitcoin as an implementation of the cryptocurrency concept was described by Wei Dai in 1998 on the cypherpunks mailing list. Dai suggested a new form of money that uses cryptography to control its creation and transactions, rather than a central authority. In 2009, the Bitcoin specification and proof of concept was published in a cryptography mailing list by Satoshi Nakamoto. As noted in the Official Bitcoin FAQ, Satoshi Nakamoto left the project in late 2010 without revealing much about himself.

Payments are made via a Bitcoin wallet application that resides on a user's computer or mobile device, and a person only needs to enter the recipient's Bitcoin address information and payment amount before pressing send to complete payment.

New bitcoins are created by a competitive and decentralized process called "mining". Bitcoin miners are processing transactions and securing the network using specialized hardware and are collecting new bitcoins in exchange. The Bitcoin protocol ensures new bitcoins are created at a fixed rate, making the process of bitcoin mining a very competitive business.

According to eWeek, efforts to improve Bitcoin mining are now under way, working under the basic assumption that the cheaper you can mine Bitcoins, the more money you can make.

While attackers are going after Bitcoin-related sites, there is an important distinction between the security of the Bitcoin network and the Bitcoin exchanges. According to InternetNews.com, no one has ever found a critical vulnerability within the Bitcoin protocol itself that would allow a user within the Bitcoin network to fraudulently create coins or forge transactions. That said, there have been compromises of various Bitcoin exchanges throughout the virtual currency's lifetime, and as the value of a Bitcoin increases, so does the risk in using exchanges.

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What Is Bitcoin Cryptocurrency? Webopedia Definition

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Bitcoin is an innovative payment network and a new kind of money. Bitcoin uses peer-to-peer technology to operate with no central authority or banks managing transactions and the issuing of bitcoins is carried out collectively by the network. Bitcoin is open-source; its design is public, nobody owns or controls Bitcoin and everyone can take part. Through many of its unique properties, Bitcoin allows exciting uses that could not be covered by any previous payment system.

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StarChild: Glossary

ASTEROID A rocky space object which can be from a few hundred feet to several hundred km wide. Most asteroids in our solar system orbit the Sun in a belt between Mars and Jupiter.

ASTRONOMER An expert in the study of the Sun, Moon, stars, planets, and other space bodies.

ASTRONOMICAL UNIT The approximate distance from the Sun to the Earth which is equal to 150,000,000 kilometers.

ASTROPHYSICS The branch of astronomy that deals with the physics of stellar phenomena.

ATMOSPHERE The layers of gases which surround a star, like our Sun, or a planet, like our Earth.

AXIS An imaginary straight line around which an object rotates.

BASALT A dark, fine-grained volcanic rock.

BIG BANG THEORY A theory which states that the Universe began to expand after a super powerful explosion of concentrated matter and energy.

BLACK HOLE The leftover core of a super massive star after a supernova. Black holes exert a tremendous gravitational pull.

CENTIGRADE See CELSIUS.

CHARGED PARTICLES electrons, protons, ions.

COMA A hazy cloud which surrounds the nucleus of a comet.

COMET Frozen masses of gas and dust which have a definite orbit through the solar system.

CORONA The very hot outermost layer of a star's atmosphere. Our Sun's corona can only be seen during a total solar eclipse.

COSMONAUT An astronaut from the former Soviet Union or the current republic of Russia.

COSMOLOGICAL Having to do with the study of the history, structure, and changes in the universe.

DENSITY The mass per unit of volume of a substance.

DOPPLER SHIFT A shift in an object's spectrum due to a change in the wavelength of light that occurs when an object is moving toward or away from Earth.

ELECTROMAGNETIC WAVE A wave of electric and magnetic energy that is generated when an electric charge is accelerated.

ELLIPTICAL Shaped like an elongated closed curve.

ENERGY Usable heat or power; in physics, it is the capacity of a physical system to perform work.

FUSION A nuclear reaction in which an element with small atoms fuses to form an element with larger atoms, releasing large amounts of energy.

GAMMA-RAYS Penetrating short wave electromagnetic radiation of very high frequency.

GEOSYNCHRONOUS An orbit in which a satellite's rate of revolution matches the Earth's rate of rotation. This allows the satellite to stay over the same site on the Earth's surface at all times.

GRAVITATIONAL FIELD The volume over which an object exerts a gravitational pull.

GRAVITATIONAL FORCE See Gravity

GRAVITATIONAL PULL See Gravity

GRAVITY The force of attraction between two objects which is influenced by the mass of the two objects and the distance between the two objects.

GYROSCOPE A heavy wheel or disk mounted so that its axis can turn freely in one or more directions. A spinning gyroscope tends to resist change in the direction of its axis.

HELIOCENTRIC Having the Sun as a center, such as a heliocentric solar system.

INFRARED WAVES Electromagnetic radiation with long wavelengths which is found in the invisible part of the spectrum. Human beings experience infrared waves as heat.

ION An electrically charged particle. Ions may be negatively or positively charged.

KILOGRAM 1000grams. A kilogram equals 2.2 pounds.

KILOMETER 1000 meters. A kilometer equals 0.6214 miles.

KILOPARSEC 1000 parsecs. A parsec equals 3.26 light years.

MANTLE The middle layer of a planet located between the crust, or surface, and the core.

MASS The measure of the amount of matter in an object.

MATTER Anything which has mass and occupies space.

METEOR Meteoroids which burn up in the atmosphere of a space body, such as the Earth, prior to impacting on the surface.

METEORITE Fragments of material that fall from space and impact on other larger space bodies.

METEOROID Fragments of material which vaporize when they have a close encounter with a space body which has an atmosphere.

METRIC TON 1000 kilograms. A metric ton equals 2,204 pounds.

MICROMETEOROID Very small pieces of matter which are encountered in space.

MICROWAVE Electromagnetic radiation which has a long wavelength (between 1 mm and 30 cm). Microwaves can be used to study the universe, communicate with satellites in orbit around Earth, and cook popcorn.

MYLAR A tough polyester material used as an insulator.

NEBULA A low density cloud of gas and dust in which a star is born.

ORBIT A specific path followed by a planet, satellite, etc.

PAYLOAD BAY The main body of the Space Shuttle where the payload, or cargo, is stored.

PHOTOSYNTHESIS The process by which plants use carbon dioxide, nutrients, and sunlight to produce food.

PHYSICIST A person who studies physics.

PHYSICS The science of matter and energy, and of interactions between the two. A person who studies physics is called a physicist.

PLAINS Vast, flat areas with low elevation.

PROBES Unmanned spacecraft which are launched into space in order to collect data about the solar system and beyond. Space probes are not necessarily designed to return to Earth.

QUASAR A distant energy source which gives off vast amounts of radiation, including radio waves and X-rays.

RETROGRADE Having a direction which is opposite that of similar bodies.

REVOLUTION The circling of a smaller object around a larger object.

ROTATION The spinning of an object on its axis.

SILICON A non-metallic chemical element.

SOLAR ECLIPSE A shadow which falls on an area of Earth when the Moon moves between the Sun and Earth.

SOLAR FLARES A magnetic storm on the Sun's surface which shows up as a sudden increase in brightness.

SOLAR PROMINENCES Gases trapped at the edge of the Sun which appear to shoot outward from the Sun's surface.

SOLAR SYSTEM The Sun and all of the planets, comets, etc. which revolve around it.

SOLAR WIND A continuous stream of charged particles which are released from the Sun and hurled outward into space at speeds up to 800 kilometers per second. Solar winds are very prominent after solar flare activity.

SOLAR WINGS A panel of solar cells which converts sunlight into electrical energy.

SPECTROGRAPH The image of the electromagnetic spectrum produced by a spectroscope.

SPECTROSCOPE An instrument which separates visible light into its various wavelengths. Each wavelength corresponds to a specific color in the spectrum.

SPECTRUM A band of colors which forms when visible light passes through a prism. The band ranges in color from violet (shorter wavelength) to red (longer wavelength).

SUNSPOT A magnetic storm on the the Sun's surface which appears as a dark area. A sunspot is approximately 1500 degrees Celsius cooler than it's surrounding material. The number of sunspots we see on the Sun at any given time appears to cycle every 11 years.

TELESCOPE Any of various devices, sometimes made with an arrangement of lenses, mirrors, or both, used to detect and observe distant objects by their emission, transmission, reflection, or other interaction with invisible radiation.

THERMOMETER An instrument for measuring temperature.

UNIVERSE The vast expanse of space which contains all of the matter and energy in existence.

The StarChild site is a service of the High Energy Astrophysics Science Archive Research Center (HEASARC), Dr. Alan Smale (Director), within the Astrophysics Science Division (ASD) at NASA/ GSFC.

StarChild Authors: The StarChild Team StarChild Graphics & Music: Acknowledgments StarChild Project Leader: Dr. Laura A. Whitlock Curator: J.D. Myers Responsible NASA Official: Phil Newman If you have comments or questions about the StarChild site, please send them to us.

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StarChild: Glossary

Smew – Wikipedia

The smew (Mergellus albellus) is a species of duck, and is the only living member of the genus Mergellus. Mergellus is a diminutive of Mergus and albellus is from Latin albus "white".[2] This genus is closely related to Mergus and is sometimes included in it, though it might be closer to the goldeneyes (Bucephala).[3] The smew has interbred with the common goldeneye (B. clangula).[4]

A seaduck fossil from the Middle Miocene shows that birds similar to smew existed up to 13million years ago. The extant species dates back to the Pleistocene.

The drake smew, with its 'cracked ice' and 'panda' appearance, is unmistakable, and looks very black-and-white in flight. The females and immature males are grey birds with chestnut foreheads and crowns, and can be confused at a distance with the ruddy duck; they are often known as "redhead" smew. It has oval white wing-patches in flight. The smew's bill has a hooked tip and serrated edges, which help it catch fish when it dives for them.

The smew is 3844cm (1517in) long.[4]

This species breeds in the northern taiga of Europe and Asia. It needs trees for breeding. The smew lives on fish-rich lakes and slow rivers. As a migrant, it leaves its breeding areas and winters on sheltered coasts or inland lakes of the Baltic Sea, the Black Sea, northern Germany and the Low Countries, with a small number reaching Great Britain (for example, at Dungeness), mostly at regular sites. Vagrants have been recorded in North America. On lakes it prefers areas around the edges, often under small trees. The smew breeds in May and lays 69 cream-colored eggs. It nests in tree holes, such as old woodpecker nests. It is a shy bird and flushes easily when disturbed.

The smew is one of the species to which the Agreement on the Conservation of African-Eurasian Migratory Waterbirds (AEWA) applies. It is not considered threatened on the IUCN Red List, though its population is decreasing.[1]

An unnamed fossil seaduck, known from a humerus found in the Middle Miocene Sajvlgyi Formation (Late Badenian, 1312 million years ago) of Mtraszls, Hungary, was assigned to Mergus. However, the authors included the smew therein, and consequently, the bone is more properly assigned to Mergellusespecially as it was more similar to a smew's than to the Bucephala remains also found at the site. It is sometimes argued[5] that the Mtraszls fossil is too old to represent any of the modern seaduck genera, but apparently these were all well-distinct even back then.[6]

Fossils from the earliest Pleistocene found in England indicate that the living species was extant 1.5 to 2.0 million years ago.[5]

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Smew - Wikipedia

Nanobiotechnology – Wikipedia

Nanobiotechnology, bionanotechnology, and nanobiology are terms that refer to the intersection of nanotechnology and biology.[1] Given that the subject is one that has only emerged very recently, bionanotechnology and nanobiotechnology serve as blanket terms for various related technologies.

This discipline helps to indicate the merger of biological research with various fields of nanotechnology. Concepts that are enhanced through nanobiology include: nanodevices (such as biological machines), nanoparticles, and nanoscale phenomena that occurs within the discipline of nanotechnology. This technical approach to biology allows scientists to imagine and create systems that can be used for biological research. Biologically inspired nanotechnology uses biological systems as the inspirations for technologies not yet created.[2] However, as with nanotechnology and biotechnology, bionanotechnology does have many potential ethical issues associated with it.

The most important objectives that are frequently found in nanobiology involve applying nanotools to relevant medical/biological problems and refining these applications. Developing new tools, such as peptoid nanosheets, for medical and biological purposes is another primary objective in nanotechnology. New nanotools are often made by refining the applications of the nanotools that are already being used. The imaging of native biomolecules, biological membranes, and tissues is also a major topic for the nanobiology researchers. Other topics concerning nanobiology include the use of cantilever array sensors and the application of nanophotonics for manipulating molecular processes in living cells.[3]

Recently, the use of microorganisms to synthesize functional nanoparticles has been of great interest. Microorganisms can change the oxidation state of metals. These microbial processes have opened up new opportunities for us to explore novel applications, for example, the biosynthesis of metal nanomaterials. In contrast to chemical and physical methods, microbial processes for synthesizing nanomaterials can be achieved in aqueous phase under gentle and environmentally benign conditions. This approach has become an attractive focus in current green bionanotechnology research towards sustainable development.[4]

The terms are often used interchangeably. When a distinction is intended, though, it is based on whether the focus is on applying biological ideas or on studying biology with nanotechnology. Bionanotechnology generally refers to the study of how the goals of nanotechnology can be guided by studying how biological "machines" work and adapting these biological motifs into improving existing nanotechnologies or creating new ones.[5][6] Nanobiotechnology, on the other hand, refers to the ways that nanotechnology is used to create devices to study biological systems.[7]

In other words, nanobiotechnology is essentially miniaturized biotechnology, whereas bionanotechnology is a specific application of nanotechnology. For example, DNA nanotechnology or cellular engineering would be classified as bionanotechnology because they involve working with biomolecules on the nanoscale. Conversely, many new medical technologies involving nanoparticles as delivery systems or as sensors would be examples of nanobiotechnology since they involve using nanotechnology to advance the goals of biology.

The definitions enumerated above will be utilized whenever a distinction between nanobio and bionano is made in this article. However, given the overlapping usage of the terms in modern parlance, individual technologies may need to be evaluated to determine which term is more fitting. As such, they are best discussed in parallel.

Most of the scientific concepts in bionanotechnology are derived from other fields. Biochemical principles that are used to understand the material properties of biological systems are central in bionanotechnology because those same principles are to be used to create new technologies. Material properties and applications studied in bionanoscience include mechanical properties(e.g. deformation, adhesion, failure), electrical/electronic (e.g. electromechanical stimulation, capacitors, energy storage/batteries), optical (e.g. absorption, luminescence, photochemistry), thermal (e.g. thermomutability, thermal management), biological (e.g. how cells interact with nanomaterials, molecular flaws/defects, biosensing, biological mechanisms s.a. mechanosensing), nanoscience of disease (e.g. genetic disease, cancer, organ/tissue failure), as well as computing (e.g. DNA computing)and agriculture(target delivery of pesticides, hormones and fertilizers.[8] The impact of bionanoscience, achieved through structural and mechanistic analyses of biological processes at nanoscale, is their translation into synthetic and technological applications through nanotechnology.

Nano-biotechnology takes most of its fundamentals from nanotechnology. Most of the devices designed for nano-biotechnological use are directly based on other existing nanotechnologies. Nano-biotechnology is often used to describe the overlapping multidisciplinary activities associated with biosensors, particularly where photonics, chemistry, biology, biophysics, nano-medicine, and engineering converge. Measurement in biology using wave guide techniques, such as dual polarization interferometry, are another example.

Applications of bionanotechnology are extremely widespread. Insofar as the distinction holds, nanobiotechnology is much more commonplace in that it simply provides more tools for the study of biology. Bionanotechnology, on the other hand, promises to recreate biological mechanisms and pathways in a form that is useful in other ways.

Nanomedicine is a field of medical science whose applications are increasing more and more thanks to nanorobots and biological machines, which constitute a very useful tool to develop this area of knowledge. In the past years, researchers have done many improvements in the different devices and systems required to develop nanorobots. This supposes a new way of treating and dealing with diseases such as cancer; thanks to nanorobots, side effects of chemotherapy have been controlled, reduced and even eliminated, so some years from now, cancer patients will be offered an alternative to treat this disease instead of chemotherapy, which causes secondary effects such as hair loss, fatigue or nausea killing not only cancerous cells but also the healthy ones. At a clinical level, cancer treatment with nanomedicine will consist on the supply of nanorobots to the patient through an injection that will seek for cancerous cells leaving untouched the healthy ones. Patients that will be treated through nanomedicine will not notice the presence of this nanomachines inside them; the only thing that is going to be noticeable is the progressive improvement of their health.[9]

Nanobiotechnology (sometimes referred to as nanobiology) is best described as helping modern medicine progress from treating symptoms to generating cures and regenerating biological tissues. Three American patients have received whole cultured bladders with the help of doctors who use nanobiology techniques in their practice. Also, it has been demonstrated in animal studies that a uterus can be grown outside the body and then placed in the body in order to produce a baby. Stem cell treatments have been used to fix diseases that are found in the human heart and are in clinical trials in the United States. There is also funding for research into allowing people to have new limbs without having to resort to prosthesis. Artificial proteins might also become available to manufacture without the need for harsh chemicals and expensive machines. It has even been surmised that by the year 2055, computers may be made out of biochemicals and organic salts.[10]

Another example of current nanobiotechnological research involves nanospheres coated with fluorescent polymers. Researchers are seeking to design polymers whose fluorescence is quenched when they encounter specific molecules. Different polymers would detect different metabolites. The polymer-coated spheres could become part of new biological assays, and the technology might someday lead to particles which could be introduced into the human body to track down metabolites associated with tumors and other health problems. Another example, from a different perspective, would be evaluation and therapy at the nanoscopic level, i.e. the treatment of Nanobacteria (25-200nm sized) as is done by NanoBiotech Pharma.

While nanobiology is in its infancy, there are a lot of promising methods that will rely on nanobiology in the future. Biological systems are inherently nano in scale; nanoscience must merge with biology in order to deliver biomacromolecules and molecular machines that are similar to nature. Controlling and mimicking the devices and processes that are constructed from molecules is a tremendous challenge to face the converging disciplines of nanotechnology.[11] All living things, including humans, can be considered to be nanofoundries. Natural evolution has optimized the "natural" form of nanobiology over millions of years. In the 21st century, humans have developed the technology to artificially tap into nanobiology. This process is best described as "organic merging with synthetic." Colonies of live neurons can live together on a biochip device; according to research from Dr. Gunther Gross at the University of North Texas. Self-assembling nanotubes have the ability to be used as a structural system. They would be composed together with rhodopsins; which would facilitate the optical computing process and help with the storage of biological materials. DNA (as the software for all living things) can be used as a structural proteomic system - a logical component for molecular computing. Ned Seeman - a researcher at New York University - along with other researchers are currently researching concepts that are similar to each other.[12]

DNA nanotechnology is one important example of bionanotechnology.[13] The utilization of the inherent properties of nucleic acids like DNA to create useful materials is a promising area of modern research. Another important area of research involves taking advantage of membrane properties to generate synthetic membranes. Proteins that self-assemble to generate functional materials could be used as a novel approach for the large-scale production of programmable nanomaterials. One example is the development of amyloids found in bacterial biofilms as engineered nanomaterials that can be programmed genetically to have different properties.[14]Protein folding studies provide a third important avenue of research, but one that has been largely inhibited by our inability to predict protein folding with a sufficiently high degree of accuracy. Given the myriad uses that biological systems have for proteins, though, research into understanding protein folding is of high importance and could prove fruitful for bionanotechnology in the future.

Lipid nanotechnology is another major area of research in bionanotechnology, where physico-chemical properties of lipids such as their antifouling and self-assembly is exploited to build nanodevices with applications in medicine and engineering.[15]

Meanwhile, nanotechnology application to biotechnology will also leave no field untouched by its groundbreaking scientific innovations for human wellness; the agricultural industry is no exception. Basically, nanomaterials are distinguished depending on the origin: natural, incidental and engineered nanoparticles. Among these, engineered nanoparticles have received wide attention in all fields of science, including medical, materials and agriculture technology with significant socio-economical growth. In the agriculture industry, engineered nanoparticles have been serving as nano carrier, containing herbicides, chemicals, or genes, which target particular plant parts to release their content.[16] Previously nanocapsules containing herbicides have been reported to effectively penetrate through cuticles and tissues, allowing the slow and constant release of the active substances. Likewise, other literature describes that nano-encapsulated slow release of fertilizers has also become a trend to save fertilizer consumption and to minimize environmental pollution through precision farming. These are only a few examples from numerous research works which might open up exciting opportunities for nanobiotechnology application in agriculture. Also, application of this kind of engineered nanoparticles to plants should be considered the level of amicability before it is employed in agriculture practices. Based on a thorough literature survey, it was understood that there is only limited authentic information available to explain the biological consequence of engineered nanoparticles on treated plants. Certain reports underline the phytotoxicity of various origin of engineered nanoparticles to the plant caused by the subject of concentrations and sizes . At the same time, however, an equal number of studies were reported with a positive outcome of nanoparticles, which facilitate growth promoting nature to treat plant.[17] In particular, compared to other nanoparticles, silver and gold nanoparticles based applications elicited beneficial results on various plant species with less and/or no toxicity.[18][19] Silver nanoparticles (AgNPs) treated leaves of Asparagus showed the increased content of ascorbate and chlorophyll. Similarly, AgNPs-treated common bean and corn has increased shoot and root length, leaf surface area, chlorophyll, carbohydrate and protein contents reported earlier.[20] The gold nanoparticle has been used to induce growth and seed yield in Brassica juncea.[21]

This field relies on a variety of research methods, including experimental tools (e.g. imaging, characterization via AFM/optical tweezers etc.), x-ray diffraction based tools, synthesis via self-assembly, characterization of self-assembly (using e.g. MP-SPR, DPI, recombinant DNA methods, etc.), theory (e.g. statistical mechanics, nanomechanics, etc.), as well as computational approaches (bottom-up multi-scale simulation, supercomputing).

Continued here:

Nanobiotechnology - Wikipedia

What is Moore’s Law? – ExtremeTech

If youve been around the internet for longer than Jayden Smith, youre probably familiar with Moores Law. Its often misquoted, often misunderstood, but its law status is rarely questioned. The most generalpossible way to state Moores Law isthis:computing power tends to approximately double every twoyears. It gained notoriety because people like laws that let them predict the future of one of the worlds biggest industries,but the very physical basis for this principle means it is slightly different and less reliable than many people believe.

Though he did not give it that name, Moores Law was first proposed in a magazine article by Intel co-founder Gordon E. Moore. What itactually saysis that the number of transistors that can be packed into a given unit of space willroughly double every two years.That prediction has remained impressively true, a fact thats allowed everything from pocket-sized smartphones to Crysis 3, and the continuing computerization of the economy.

Moores Law scaling

Yet, stated as a precaution about human abilities in physical manufacturing, and divorced from rather airy ideas like computing power, it becomes clear why Moores Lawwont necessarily always hold true. Remember that when Moore made his original prediction, hepredicted a doubling every year, but he quickly amended this to every two years. Physical limitations on the manufacturing of these chips could easily push that number back to five years or more, effectively invalidating Moores Law forever, and revealing it to be nothing more than Moores Very Good But Ultimately Limited Prediction (MVGBULP).

Gordon Moore, co-founder of Intel.

Today, all consumer processors are made out of silicon the second most abundant element in the Earths crust, after oxygen. But silicon is not a perfect conductor, and limits to the mobility of the electrons it carries impose a hard limit on how densely you can pack silicon transistors. Not only does power consumption come a huge issue,butaneffectcalledquantum tunneling can cause problems for keeping electrons contained beyond a certain thicknessthreshold.

Outside of research facilities, silicon transistors dont currently get smaller than 14 nanometers and while some 10 nanometer chips designs might someday reach the market, its seen as a foregone conclusion that to keep to Moores Law over a long period of time, well have to come up with newer and better materials to be the basis of next generation computers.

One oft-cited example is graphene, or the rolled up tubes of graphene called carbon nanotubes. Graphene is atomically thin, often called two-dimensional, and so it allows a huge increase on the physical side of things. On the other hand, graphene does not have a useful bandgap the energy differencewe need to navigate to bumpelectrons back and forth betweenthe conducting and non-conducting bands. Thats how silicon transistors switch on and off, which is the entire basis for their method of computation.

If this problem cant be offset in some way, a graphene computer would have to pioneer a whole new logical method for computing. One graphene computer chip from IBM proved to be incredibly fast, 10,000 times faster than a silicon chip but it was not a general-purpose processor. Since graphene cant be easily switched on and off in mass quantities, we cant simply swap in graphene for silicon and keep on with modern chip architectures.

Sebastian Anthony holding a wafer of graphene chips at IBM Research.

Other materials may offer more practical reductions in size and electrical resistance, and actually allow Moores Law to continue unbroken, but only if they hit the market quickly enough.Silicon-germanium, or just germanium alone, have been talked about for some time, but have yet to really materialize in any sort of affordable form. It wasrecently discovered that a material called titanium tri-sulfide can provide many of the same physical advantages as graphene, and do so with an achievable bandgap such a super-material might be whats needed, but graphene-like problems with manufacturing then rear their ugly heads.

Quantum computing could be another answer, but research is still so preliminary that its doubtful. Some believe theyll offer such a huge and immediate upgrade over modern processors that computer encryption will come tumbling down. However, quantum computing wont necessarily come in the form of a programmable digital computer right away; early quantum computers wont be able to run Windows, even if they are more than fast enough in a theoretical sense. Of all the possible solutions to looming problems with Moores Law, quantum computing is probably the least realistic. It has a lot of potential for specific applications, but quantum PCs are still too far out to be worth considering.

Moore himself admittedthat his Law cant continueforever in a 2005 interview. Its the nature of exponential functions, he said they eventually hit a wall, and while that makes perfect sense in the purely hypothetical world of mathematics, it tends not to work out as well in the real world. It could be that Moores Law will hold up when viewed on the century scale, zoomed out to diminish the importance of any small fluctuations between new technologies. But the fact remains that right now, were entering a lull as we wait for the next great processing tech to arrive.

Check out our ExtremeTech Explains series for more in-depth coverage.

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What is Moore's Law? - ExtremeTech

Free genetic engineering Essays and Papers – 123helpme

Title Length Color Rating The Effects of Genetic Engineering on Agriculture - Genetic engineering is a way in which specific genes for an animal or plant can be extracted, and reproduced to form a new animal or plant. These new organisms will express the required trait for that gene. This practice is a very controversial topic within the scientific world. It is being implemented in various areas such as agriculture even though there are many alternatives that can be found for genetic engineered crops, such as organic materials and reducing leeching of the soil. The controversy regarding this practice occurs as it is believed to contribute both negative and positive implications and dangers, not only to oneself but the environment as a whole.... [tags: Genetic Engineering ] :: 5 Works Cited 1303 words (3.7 pages) Strong Essays [preview] Pros and Cons of Genetic Engineering - Genetic Engineering is highly controversial since some people believe that genetic engineering is playing God. As this fact there is opposition to the progression of the field by people who do not see the value in genetic engineering, or they fear what genetic engineering may lead to for us as people. There is a history of discover that belongs to genetic engineering, which has led to numerous products that have emerged which have brought numerous applications to the society of the world. Though there are benefits to genetic engineering, there are also drawbacks to genetic engineering including ethical and legal issues that are dealt with in todays society in order to try and regulate the... [tags: Genetic Engineering] :: 8 Works Cited 2049 words (5.9 pages) Term Papers [preview] The Benefits of Genetic Engineering - Almost three decades ago, on July 25, 1978, Louise Brown, the first test tube baby was born (Baird 1). With this birth another controversy broke out, do humans have the right to make life. 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The other form, genetic reconstruction, is used to replace genes within humans to help or enhance the life of an unborn child for a medical reason or just for the preference of a parent.... [tags: Genetic Engineering ] :: 5 Works Cited 1437 words (4.1 pages) Powerful Essays [preview] Apocalyptic Visions of Genetic Engineering - Global warming, nuclear winter, microscopic black holessociety views all these as apocalyptic phenomena resulting from the accelerating rate of discovery in the fields of science and technology. Opinions on fields like climate change and atomic weaponry certainly have a basis in scientific evidence, but many other apocalyptic reactions derive from hypothetical situations and thought experiments. To further examine public opinions on scientific fields, we can examine genetic engineering (GE). 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[tags: Genetic Engineering ] :: 7 Works Cited 1806 words (5.2 pages) Term Papers [preview] Genetic Engineering in Humans - Author Chuck Klosterman said, The simple truth is that were all already cyborgs more or less. Our mouths are filled with silver. Our nearsighted pupils are repaired with surgical lasers. We jam diabetics full of delicious insulin. Almost 40 percent of Americans now have prosthetic limbs. We see to have no qualms about making post-birth improvements to our feeble selves. Why are we so uncomfortable with pre-birth improvement? Despite Klostermans accurate observation, there are reasons people are wearisome toward pre-birth enhancement.... [tags: Genetic Engineering ] 859 words (2.5 pages) Better Essays [preview] Genetic Engineering: The Impact of Human Manipulation - The scenes of a science fiction movie show presumably unrealistic scientific inventions. In today's world, time travel, cloning, and even light sabers are some of the countless topics that are seemingly unattainable and just ideas of the imagination. Saying that these events are feasible would be completely absurd. However, with recent scientific advancements, science fiction is now becoming more of a reality rather than a fantasy. Nevertheless, only about twenty-five years ago, genetic engineering fell into this same, idealistic category.... [tags: Genetic Engineering ] :: 6 Works Cited 1725 words (4.9 pages) Better Essays [preview] Genetic Engineering: A Major Advancement for Mankind - As the Biochemist Isaac Asimov once said, "The advancement of Genetic Engineering makes it quite conceivable that we will design our own evolutionary progress. Scientists have always thought about new ways to progress through technology in our era, and in 1946, scientists discover that Genetic material from different viruses can be combined to form a new type of virus. This was a major discovery that trickles down to the modern era of Genetics. Current scientists have pioneered new ways to decode human DNA, beating the $3 billion government-run Genome project to its goal.... [tags: Genetic Engineering] :: 10 Works Cited 973 words (2.8 pages) Strong Essays [preview] Genetic Engineering: Is the Human Race Ready? - It is incredible to see how far genetic engineering has come. Humans, plants, and any living organism can now be manipulated. Scientists have found ways to change humans before they are even born. They can remove, add, or alter genes in the human genome. Making things possible that humans (even thirty years ago) would have never imagined. Richard Hayes claims in SuperSize Your Child. that genetic engineering needs to have limitations. That genetic engineering should be used for medical purposes, but not for genetic modification that could open the door to high-tech eugenic engineering (188).... 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It is called that because it is missing one oxygen atom, and it is located in the nucleus. It is also in the form of an acid. DNA is made up of four subunits: Adenine, Thymine, Guanine and Cytosine. During the production of RNA, the messenger of DNA, Uracil is used instead of thymine. A small segment of this DNA is called a gene.... [tags: dna, Genetic Engineering, genes] :: 8 Works Cited 1513 words (4.3 pages) Powerful Essays [preview] Genetic Engineering Is Not Safe - Genetic engineering is the intended modification to an organisms genetic makeup. There have been no continuing studies on this topic or action so there is no telling whether or not it is harmless. Genetic engineering is not safe because scientists have no absolute knowledge about living systems. Given that, they are unable to do DNA surgery without creating mutations. Any interference on an organisms genetic makeup can cause permanent damage, hereditary defects, lack of nutritious food, or a spread of dangerous diseases.... [tags: Genetic Engineering Essays] :: 5 Works Cited 994 words (2.8 pages) Good Essays [preview] Genetic Engineering: A Step Forward - Genetic engineering (GE) refers to the technique of modification or manipulation of genes (the biological material or chemical blue print that determines a living organisms traits) from one organism to another thus giving bacteria, plants, and animals, new features. The technique of selecting the best seed or the best traits of plants has been around for centuries. Humans have learned to graft (fuse) and hybridize (cross breed) plants, creating dwarfs and other useful forms since at least 1000 B.C.... [tags: Genetic Engineering Essays] 498 words (1.4 pages) Strong Essays [preview] Benefits of Genetic Engineering - Genetic Engineering is an idea that we can ponder on quiet days. 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[tags: Genetic Engineering Essays] :: 2 Works Cited 715 words (2 pages) Strong Essays [preview] The Benefits of Genetic Engineering - The engineering of deoxyribonucleic acid (DNA) is entirely new, yet genetics, as a field of science, has fascinated mankind for over 2,000 years. Man has always tried to bend nature around his will through selective breeding and other forms of practical genetics. Today, scientists have a greater understanding of genetics and its role in living organisms. Unfortunately, some people are trying to stop further studies in genetics, but the research being conducted today will serve to better mankind tomorrow.... [tags: Genetic Engineering Essays] 1109 words (3.2 pages) Strong Essays [preview] The Benefits of Genetic Engineering - Many people are envied or deprecated because of certain traits they are born with. Those that are envied are a select few, which in turn is why they are envied. When one child in a nursery has a toy, he is coveted by all the other children in the nursery. He will be idolized, and nearly every child will want to be his friend. However, there will also those that want the toy for themselves. The children that are jealous will do whatever they can to get the toy. The jealous children often resort to violence, and this is true in all aspects of life.... [tags: Genetic Engineering Essays] 975 words (2.8 pages) Strong Essays [preview] Genetic Engineering and the Media - Genetic engineering and its related fields have stimulated an extremely controversial scientific debate about cloning for the last decade. With such a wide range of public opinions, it is hard to find any middle ground. Some feel that improving the genes of future children will help mankind make a major evolutionary step forward. Others agree that there could be dangerous unforeseen consequences in our genetic futures if we proceed with such endeavors. A third group warns that the expense of genetic enhancement will further separate the wealthy from the poor and create a super race. Popular magazines and the Internet are two of the major arenas in which this debate has been hotly cont... [tags: Genetic Engineering Essays] :: 21 Works Cited 1731 words (4.9 pages) Powerful Essays [preview] The FDA Should Prohibit Genetic Engineering - Abstract: Recent developments in genomic research have enabled humans to manipulate the genes of living organisms with genetic engineering. Scientists have used this momentous technology in environmental and most recently, agricultural spheres. However, the United States Food and Drug Administration (FDA) does not require that genetically altered foods be labeled as such. As a result, there is no protection against humans' ability to construct organisms that nature never intended to exist and to threaten nature's carefully balanced environment. Is it ethically responsible for the government to allow scientists to continue with these advances if they do not understand their consequences.... [tags: Genetic Engineering, Genetic Ethics] :: 10 Works Cited 2439 words (7 pages) Powerful Essays [preview] Genetic Engineering is Immoral - Genetic engineering gives the power to change many aspects of nature and could result in a lot of life-saving and preventative treatments. Today, scientists have a greater understanding of genetics and its role in living organisms. However, if this power is misused, the damage could be very great. Therefore, although genetic engineering is a field that should be explored, it needs to be strictly regulated and tested before being put into widespread use. Genetic engineering has also, opened the door way to biological solutions for world problems, as well as aid for body malfunctions.... [tags: Genetic Engineering Essays] 423 words (1.2 pages) Strong Essays [preview] Genetic Engineering is Unethical - Just as the success of a corporate body in making money need not set the human condition ahead, neither does every scientific advance automatically make our lives more meaningful'; (Wald 45). These words were spoken by a Nobel Prize winning biologist and Harvard professor, George Wald, in a lecture given in 1976 on the Dangers of Genetic Engineering. This quotation states that incredible inventions, such as genetic engineering, are not always beneficial to society. Genetic engineering is altering the genetic material of cells and/or organisms in order to make them capable of making new substances or performing new functions'; (Wald 45).... [tags: Genetic Engineering is Immoral] :: 3 Works Cited 1141 words (3.3 pages) Better Essays [preview] Genetic Engineering is Unethical - Genetic engineering is a technology that has been created to alter DNA of different species to try and make them more improved. This essay will discuss the eugenics, the religious point of view about genetic engineering, genetically modified food and the genetic screening of embryos. In this essay it will be said wether genetic engineering is ethical or unethical. During 1924 Hitler said that everyone needs to be blond hair, blue eyes and white. This is known as Eugenics, thanks to a new science known as biotechnology in a few decades.... [tags: Genetic Engineering Essays] 492 words (1.4 pages) Strong Essays [preview] Genetic Engineering: Playing God - Current technology has made what once seemed impossible, mapping the human genome, a reality within the next decade. What began over forty years ago with the discovery of the basic structure of DNA has evolved into the Human Genome Project. This is a fifteen-year, three billion dollar effort to sequence the entire human genetic code. The Project, under the direction of the U.S. National Institute of Health and the department of Energy is ahead of schedule in mapping what makes up an individual's genetic imprint.... [tags: Genetic Engineering Essays] 634 words (1.8 pages) Strong Essays [preview] Genetic Engineering: Playing God - Regenerating extinct species, engineering babies that are born without vital body organs, this is what the use of genetic engineering brings to the world. In Greek myth, an chimera was a part lion, part goat, part dragon that lived in Lycia; in real life, its an animal customized with genes of different species. In reality, it could be a human-animal mixture that could result in horror for the scientific community. In myth the chimera was taken down by the warrior Bellerophon, the biotech version faces platoons of lawyers, bioethicists, and biologists (Hager).... [tags: Genetic Engineering Essays] :: 8 Works Cited 1804 words (5.2 pages) Strong Essays [preview] Genetic Engineering Research Paper - I. Introduction In the past three decades, scientists have learned how to mix and match characteristics among unrelated creatures by moving genes from one creature to another. This is called genetic engineering. Genetic Engineering is prematurely applied to food production. There are estimates that food output must increase by 60 percent over the next 25 years to keep up with demand. Thus, the result of scientist genetically altering plants for more consumption. The two most common methods for gene transfer are biological and electromechanical.... [tags: Science Biology Genetic Engineering Essays] :: 3 Works Cited 1347 words (3.8 pages) Strong Essays [preview] Human Genetic Engineering: Unnatural Selection - Introduction Technology has a significant influence across the world, as it has become a fast growing field. Modern biotechnology has been in the major forefront of this influence. From the discovery of DNA to the cloning of various animals, the study of genetic engineering has changed the way society views life. However, does genetic engineering have the capacity to influence the world to its best abilities. Products, which are genetically engineered, may cause severe negative effects on our society.... [tags: Genetic Engineering Essays] :: 3 Works Cited 1509 words (4.3 pages) Strong Essays [preview] Genetic Engineering - At the Roslin Institute in Edinburgh, Scotland, Dr. Keith Campbell, director of embryology at PPL therapeutics in Roslin, and his colleague Dr. Ian Wilmut worked together on a project to clone a sheep, Dolly, from adult cells. On February 22, 1997, they finally succeeded. Dolly was the only lamb born from 277 fusions of oocytes with udder cells. Wilmut says there were so many failures because it is difficult to ensure that the empty oocytes and the donor cell are at the same stage of the cell division cycle.To clone Dolly, basically scientists took an unfertilized egg cell, removed the nucleus, replaced it with cells taken from the organism to be cloned, put it into an empty egg cell which... [tags: Genetic Engineering Essays] 1446 words (4.1 pages) Strong Essays [preview] Genetic Engineering: Our Key to a Better World - What is genetic engineering one might ask and why is there so much moral controversy surrounding the topic. Genetic engineering as defined by Pete Moore, "is the name given to a wide variety of techniques that have one thing in common: they all allow the biologist to take a gene from one cell and insert it into another" (SS1). Such techniques included in genetic engineering (both "good" and "bad") are, genetic screening both during the fetal stage and later in life, gene therapy, sex selection in fetuses, and cloning.... [tags: Genetic Engineering Essays] :: 3 Works Cited 1117 words (3.2 pages) Better Essays [preview] Genetic Engineering and Cryonic Freezing: A Modern Frankenstein? - Genetic Engineering and Cryonic Freezing: A Modern Frankenstein. In Mary Shelley's Frankenstein, a new being was artificially created using the parts of others. That topic thus examines the ethics of "playing God" and, though written in 1818, it is still a relevant issue today. Genetic engineering and cryogenic freezing are two current technologies related to the theme in the novel of science transcending the limits of what humans can and should do. Genetic engineering is widely used today.... [tags: Genetic Engineering Essay Examples] :: 5 Works Cited 1507 words (4.3 pages) Powerful Essays [preview] Genetic Engineering: The Tremendous Benefits Outweigh the Risks - Wouldn't it be great to improve health care, improve agriculture, and improve our quality of life. Genetic engineering is already accomplishing those things, and has the potential to accomplish much more. Genetic engineering, also referred to as biotechnology, is a fairly new science where the genes of an organism are modified to change the features of an organism or group of organisms. Genes are found in the DNA (deoxyribonucleic acid) of an organism, and each gene controls a specific trait of an organism.... [tags: Genetic Engineering Essay Examples] :: 7 Works Cited 2253 words (6.4 pages) Powerful Essays [preview] Genetic Engineering Brings More Harm Than Good - Until the recent demise of the Soviet Union, we lived under the daily threat of nuclear holocaust extinguishing human life and the entire biosphere. Now it looks more likely that total destruction will be averted, and that widespread, but not universally fatal, damage will continue to occur from radiation accidents from power plants, aging nuclear submarines, and perhaps the limited use of tactical nuclear weapons by governments or terrorists. What has gone largely unnoticed is the unprecedented lethal threat of genetic engineering to life on the planet.... [tags: Genetic Engineering Essays] 1953 words (5.6 pages) Strong Essays [preview] Genetic Engineering New Teeth - The article I read was about some scientists that were able to grow teeth inside rats bodies. This project was led by Pamela C. Yelick, a scientist for Forsyth Institute, and the project was conducted in Massachusetts. Joseph P. Vacanti, a tissue engineer at Massachusetts General Hospital, and Yelick had the idea for the experiment. Vacanti had previously worked with rats and he found that cells will naturally organize themselves into tissues and other complex structures if they are placed in the right environment.... [tags: Genetic Engineering Essays] 736 words (2.1 pages) Strong Essays [preview] Ethics of Human Cloning and Genetic Engineering - INTRODUCTION When the Roslin Institute's first sheep cloning work was announced in March 1996 the papers were full of speculation about its long-term implications. Because of this discovery, the medias attention has focused mainly on discussion of the possibility, of cloning humans. In doing so, it has missed the much more immediate impact of this work on how we use animals. It's not certain this would really lead to flocks of cloned lambs in the fields of rural America, or clinically reproducible cuts of meat on the supermarket shelves.... [tags: Genetic Engineering Essays] :: 9 Works Cited 1845 words (5.3 pages) Strong Essays [preview] We Must Educate Ourselves Before Passing Laws Restricting Cloning and Genetic Engineering - Biotechnology and genetic engineering involve the cloning of animal cells and organisms, but they also involve the alteration of an organism in an effort to make it more perfect, whether it is a crop, an animal, or even a human being. Obviously the cloning of humans or the cloning of human cells is much different than the cloning of genetically superior livestock or a better quality, higher yielding food crop, and people throughout the world realize this. The cloning of human beings has become one of the worst fears in our society today and for that reason many laws have been passed throughout European countries and North America in an effort to ban human cloning.... [tags: Genetic Engineering Essays] :: 4 Works Cited 1937 words (5.5 pages) Powerful Essays [preview] The Benefits of Human Genetic Engineering - Pre-implantation genetic diagnosis is a revolutionary procedure that utilizes in vitro fertilization to implant a healthy egg cell into the mothers uterus after it is screened for mutations or other abnormalities. That way, only healthy eggs can develop to term and become beautiful, bouncing boys or girls. Designer babies have a bright future in the face of science because they are genetically engineered to be: disease free; viable donors for a sibling or parent; and with optional elimination of any severe cosmetic disorders that might develop,without risk to human diversity in the future.... [tags: Pre-implantation genetic diagnosis, PGD] :: 6 Works Cited 1650 words (4.7 pages) Powerful Essays [preview] Genetic Engineering The Perfect Child - Modern society has an unquestionable preoccupation with perfection. Indulging in our vanities with things such as plastic surgery, veneers, botox, collagen, hair dye, and so on, have become a part of the socially acceptable norm. People do these things, and more, in an attempt to become their ideal selves. However, many are taking these practices to a completely new extreme, and are not stopping at just altering their own physical characteristics. With recent advances in medical science and technology, couples are now able to genetically modify embryos to create their ideal children.... [tags: Pre-Implantation Genetic Diagnosis] :: 2 Works Cited 1022 words (2.9 pages) Strong Essays [preview] The Morals and Ethics of Genetic Engineering - Introduction Widely considered a revolutionary scientific breakthrough, genetic engineering has been on a path toward changing the world since its introduction in 1973 by Stanley Cohen and Herbert Boyer (What). However, as genetic engineering slowly permeates the lives of humanity, the morals and ethics behind what are now common practices are entering public attention, and as a culture we are left to question whether the change brought on by such a discovery bring benefits and positive change, or damage and destruction.... [tags: genetics, theology, bioethics, DNA, GMOs] :: 13 Works Cited 3322 words (9.5 pages) Research Papers [preview] The Human Genetic Engineering Debate - Science is moving forward at an increasing rate every day. Just in the past decade, there have been numerous new discoveries in astronomy, chemistry, geology, paleontology, and many more scientific fields. However, some of the fastest growing subjects are in the field of biological sciences, more specifically genetics. Over the past twenty years a new genetic science known as genetic engineering has come to prominence. Genetic engineering is the direct manipulation of an organisms genome using biotechnology, including a humans genome.... [tags: Genetics, Science Ethics] :: 9 Works Cited 1838 words (5.3 pages) Better Essays [preview] Genetic Engineering in the Modern World - Advances in biotechnology can be looked at two ways; both, positive and negative. People can also differ in what would qualify as a positive and negative way. Some may think that tinkering with Deoxyribonucleic acid also know as DNA, should not be allowed at all for any reason. Others may believe that manipulating human DNA can have many different beneficial outcomes. Biotechnology and genetic engineering can be looked at in two very different ways; can either be misused or unethical or it can be beneficial, ethical, and used for the better kind.... [tags: biotechnology, DNA, abortion] :: 1 Works Cited 966 words (2.8 pages) Better Essays [preview] Genetic Engineering and the Pursuit of Perfection - Research Paper Rough Draft In the year 2050, a young boy nervously rehearses what hes going to say as he approaches the cheerleader hes been too nervous to approach for the past month. But as he draws near, a jock pushes his books out of his hands. Hes teased, being the school wimp. They call him names like undesirable, god-child, and in-valid. Of course nobody cares for a less-than-perfect child whose genetic makeup was left to fate. With the introduction of genetic engineering into society, people like this young boy simply have no hope for competing against the likes of the genetically reimagined, perfect jock, people engineered to be unflawed.... [tags: Perfection, Body Image, Technology] :: 10 Works Cited 1898 words (5.4 pages) Powerful Essays [preview] Genetic Engineering: Pros and Cons - Our world has finally begun its long-predicted descent into the depths of chaos. We may not yet realize it, but more and more problems plague the very state of our humanity with each passing day, such as cancer, famine, genetic disorders, and social elitism. It seems as though there is little hope, although a new solution has finally emerged, in the form of genetic engineering. It is apparent, however, that currently we cannot proceed, because while there are an abundant amount of advantages to genetic engineering, it is not a utopian process; criticism includes its practicality, theological implications, and changes in modern social structure.... [tags: Eugenics, Ethics] :: 5 Works Cited 1212 words (3.5 pages) Strong Essays [preview] Is Genetic Engineering Ethically Right? - Described at its most simple, ethics can be described as a socially constructed set of behaviours and beliefs deemed either acceptable or unacceptable by the vast majority of people. Ethical beliefs can vary somewhat from person to person and are ever changing and malleable (www.ncbi.nlm.gov/pubmed/15289521). There are three main ethical theories used by present day philosophers; these are Meta-ethics, Normative ethics and Applied ethics. Meta-ethics focuses on the nature of moral judgement and the foundation of ethical principles.... [tags: DNA, gene, diabetis] :: 10 Works Cited 1191 words (3.4 pages) Strong Essays [preview] Genetic Engineering and the Public - Genetic Engineering and the Publics Uses of Genetic Engineering Opinions about genetic engineering range from disgust to awe. These opinions may also depend on what type of animal is being genetically manipulated, how such manipulation is being done, and for what reasons. In California, pet fish that have been genetically altered to fluoresce (glofish) have been restricted for sale.[1] Yet, for the rest of the United States these fish are found in several species, varieties and morphs. In California, Commissioner of Californias Fish and Game, Sam Schuchat, felt that there was a difference in genetic modification depending on the use of the product made.[2] The use of genetic engineering f... [tags: Stake Holders, Science, Dialogue] :: 6 Works Cited 877 words (2.5 pages) Better Essays [preview] Genetic Engineering: A Good Thing? - Today there are many definitions of Genetic Engineering, such as Genetic Engineering is a laboratory technique used by scientists to change the DNA of living organisms (Kowalski) and Genetic Engineering refers to the modification or manipulation of a living organisms genes (Genetic). No matter the wording all definitions of genetic engineering refers to somehow changing an organisms genetic identity. Many people today support genetic engineering because it has many potential benefits for today's society; however, it also has many potential threats associated with it.... [tags: argumentative, persuasive, informative] :: 19 Works Cited 1928 words (5.5 pages) Powerful Essays [preview] Genetic Engineering and its Drawbacks - In the past few years, there have been numerous technological advances, one of them being genetic engineering. Scientists are experimenting with genes and animals to create everything from a Day-Glo pet fish to a pig whose liver could be used in a liver transplant for humans. Scientists argue that genetic engineering can be used to test medicinal products without putting humans at risk, to battle diseases and to make a body with a stronger immune system, amongst many other reasons, which they claim are to improve the outcome of the human race.... [tags: gene, transplant, animal testing] :: 9 Works Cited 911 words (2.6 pages) Better Essays [preview] The Perfect Child: Genetic Engineering - Have you ever wondered what it would be like if you could produce the perfect child. You picked their eye color, hair color, body type, even intelligence level. Instead of waiting nine months to see what your child looks like; you will already know because you chose their outer appearance. Improvements in science, has given way to the idea of allowing people to choose their offsprings physical attributes. This new concept is known as designer babies. A designer baby according to the oxford dictionary is a baby whose genetic makeup has been artificially selected by genetic engineering, combined with in vitro fertilization to ensure the presence or absence of particular genes or characteris... [tags: Designer Babies, Stem Cells] :: 5 Works Cited 899 words (2.6 pages) Better Essays [preview] Cons of Genetic Modification of Plants - In our everyday lives we have a substantial need for food. Everyone on planet earth needs food to survive from day to day, so engineers have begun mutating plants and crops to create a better source of nutrition to the population. Scientists are pushing the boundaries in order to create the most bountiful crops and, in turn, healthier people. Imagine what could happen if there were larger harvests, more succulent fruits and nutritious vegetables. Our imagination can run wild with the endless possibilities of genetic alteration of food.... [tags: Genetic Engineering ] :: 5 Works Cited 1011 words (2.9 pages) Strong Essays [preview] Germline Engineering and Reprogenetic Technologies - Modern technologies are constantly advancing in a multitude of ways to the degree that scientists have gained enough knowledgeable about the human genome to be able to find specific genes during the embryonic stage of reproduction. Scientists have already begun to use this knowledge to allow parents the ability to select the sex of their child and screen for genetic diseases via preimplantation genetic diagnosis (PGD) with in vitro fertilization (IVF). Sex-selection has already created world-wide discussion regarding the ethics of such a situation.... [tags: Genetic Engineering ] :: 4 Works Cited 2055 words (5.9 pages) Term Papers [preview] Genetic Engineering and Experimentation - ... However, Ill be using it in the context that it is the experimentation of genetic engineering to see if its safe for the public. While you might think genetic engineering/experimentation is all fun and games while youre having your genes modified to make you smarter, or prettier, or something like that, there are consequences and dangers that can come with that modification. Then again, once perfected, genetic engineering could do a lot of good for humanity and society in general. Eliminate diseases, fix mental and psychological disabilities, maybe even (and semi-hopefully) keep people from being outright stupid.... [tags: Science, Controversy] :: 4 Works Cited 880 words (2.5 pages) Better Essays [preview] The Genetic Engineering Debate - In recent discussions of genetic engineering, a controversial issue has been whether genetic engineering is ethical or not. In The Person, the Soul, and Genetic Engineering, JC Polkinghorne discusses about the moral status of the very early embryo and therapeutic cloning. J. H. Brookes article Commentary on: The Person, the Soul, and Genetic Engineering comments and state opinions that counter Polkinghornes article. On the other hand John Harriss Goodbye Dolly? The Ethics of Human Cloning examines the possible uses and abuses of human cloning and draw out the principal ethical dimensions, both of what might be done and its meaning, and of public and official response (353).... [tags: Ethical Dilemma, Embryos With Dignity] :: 4 Works Cited 1403 words (4 pages) Powerful Essays [preview] Ethics of Genetic Modification Technology - Modern society is on the verge of a biotechnological revolution: the foods we eat no longer serve simply to feed us, but to feed entire nations, to withstand natural disasters, and to deliver preventative vaccination. Much of this technology exists due to the rapid development of genetic modification, and todays genetically modified crops are only the tip of the proverbial iceberg. Says Robert T. Fraley, chief technology officer for biotech giant Monsanto, Its like computers in the 1960s. We are just at the beginning of the explosion of technology we are going to see." Biotechnologys discontents are numerous and furious, declaring the efforts of corporations of Monsanto to be dangerous... [tags: Genetic Engineering] 776 words (2.2 pages) Better Essays [preview] Xerosotmia and genetic engineering - All around the globe, predominantly in the United States and in Europe, there are technological advances in science that affects the way people live. In recent years, genetically modified organisms (GMOs) have replaced peoples diet with genetically altered foods, which has affected human health. In a broad view, GMOs are created by splicing genes of different species that are combined through genetic engineering, consequently improving the resulting organism. Large corporations who choose to use Xerosotmia i i make larger profits with less time and effort involved (ABNE).... [tags: biology, genetically modified organisms] :: 4 Works Cited 1309 words (3.7 pages) Powerful Essays [preview] The Dangers of Genetic Engineering - Genetically manipulating genes to create certain traits in a human embryo is impossible at this point. Perhaps it will never happen. It is not inevitable in the long run, as some scientists pragmatically point out. (Embgen). It is, however, something that dominates modern day discussion concerning genetics and therefore must be addressed with care and consideration. There are many ways that gene manipulation could come about. Advances in spermatogenesis as well as the field of assisted reproductive technology, as seen in In Vitro Fertilization clinics, point toward methods that could house the systematic alteration of genetic information in reproductive cells. Transpl... [tags: Genetic Manipulation Essays] :: 5 Works Cited 1033 words (3 pages) Strong Essays [preview] Engineering the Perfect Human - For centuries, mankind has been fascinated by the idea of perfection. In recent decades, the issue has been raised regarding the perfect human and whether scientists are able to engineer and create this. Attempts have been made in the past to engineer this said perfect human, through eugenics and scientific racism, but until now, these attempts have been ineffective. Only now, with modern technology, are scientists able to make more significant progress in altering the human genome to the produce desired characteristics of perfection.... [tags: Genetic Engineering ] :: 21 Works Cited 1831 words (5.2 pages) Term Papers [preview] Can Genetic Modification Benefit Humanity? - Throughout the course of human history, new technological advancements have always created opposing views, and conflict between the different groups that hold them. Today, one of the greatest technological controversies is over the morals and practicality of genetically modifying crops and animals. Reasons for doing so vary from making them more nutritious to making plants more bountiful to allowing organisms to benefit humans in ways never before possible. Genetic engineering is a process in which genes within the DNA of one organism are removed and placed into the DNA of another, a reshuffling of genesfrom one species to another (Steinbrecher qtd.... [tags: Genetic Engineering] 1676 words (4.8 pages) Powerful Essays [preview] Genetic Engineering - In the field of animal and human genetic engineering there is much more speculation, than fact, because very little has actually been tested in the real world. Firstly, theres a big question mark over safety of genetic engineering. In addition, genetic engineering can cause greater problems than that what we have today. Moreover, we can create a injustice world between Designer vs Non-designer children. Furthermore, genetic engineering is a type of murder because of the process of genetically modifying a baby.... [tags: designer babies, perfect baby] :: 5 Works Cited 911 words (2.6 pages) Better Essays [preview] Genetic Engineering - Imagine a world where diseases can be found and prevented before they happen. This would be a future possibility if genetic engineering became more advanced. Genetic engineering is when parts of DNA are spliced into another piece of DNA which give new traits to the organism containing the DNA. Through continued research in the field of genetics, techniques such as mapping genomes and splicing DNA can be used beneficially to improve on existing organisms and their traits. To help understand genetic engineering, it is important to understand its history.... [tags: Cloning] :: 4 Works Cited 894 words (2.6 pages) Better Essays [preview] Genetic Engineering - In the 21st century, times are changing. Everyday objects are becoming perfect with alterations to their system. These alterations are not only occurring on man-made objects, but also on natural organisms, such as newborn babies. Science has come a long way to being able to have the capability to alter pre-born babies to a parents desire. There are four arguments that can be considered when discussing this topic, including nature and three others. While many scientific minds are all for creating perfection in a child, many different groups of minds are arguing this act against nature should be abolished from scientists minds.... [tags: Ethics] 888 words (2.5 pages) Better Essays [preview] Genetic Engineering - I, as a Christian, believe that the traits of a child are a blessing to a parent in one-way or another. Although I hold this true, I actually wouldnt mind being able to design my own baby. I mean, I could root out all of the bad traits, and add the ones I want. I would make my child a girl with olive skin, brown hair, bright green eyes, and to have the dancing feet of Fosse, the facial expressions of Liz Taylor, and the vocal chords of Lea Michelle. I want her to be a star of the screen or stage.... [tags: controversy, genes, physical traits, flaws] :: 3 Works Cited 890 words (2.5 pages) Better Essays [preview] Genetic Engineering - Moore's law, the statement that technologies will double every two years is a very thought-provoking inception for technologist and scientist (Moore's Law par.1). Numerous people are thrilled about this commandment while others are petrified. Why an individual might be troubled by technology one might inquire. Well there are many arguments that claim that technology is contrary to itself, nature, and humans. The unpretentious fact is technology is cohesive within the humanoid existence and will linger as time travels on.... [tags: genetically modified foods] :: 13 Works Cited 1461 words (4.2 pages) Powerful Essays [preview] Human Genetic Engineering: Dreams and Nightmares - Technological breakthroughs and advancements have occurred so rapidly since the dawn of the information age, that one often overlooks the great power humanity holds over the building blocks of life itself. While our understanding and mapping of Deoxyribonucleic acid (DNA) sequences has been slow coming since Friedrich Mieschers isolation of the double-helix shaped molecule, efforts in recent decades to map the human genome have opened many doors to the potential manipulation of lifes basic elements.... [tags: human genome, human genetics, cloning] :: 7 Works Cited 1162 words (3.3 pages) Strong Essays [preview]

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Free genetic engineering Essays and Papers - 123helpme

Could gene therapy become biotechs growth driver in 2017 …

Despite bouncing off a 2-year low, biotech is still an unpopular sector and investors are rightfully concerned about its near-term prospects. Recent drug failures, growing pricing pressure and the potential impact of biosimilars all contribute to the negative sentiment, but the main problem is the lack of growth drivers for the remainder of 2016 (and potentially 2017).

The biotech industry relies on innovation cycles to create new revenue sources. This was the case in the 2013-2014 biotech bull market, which was driven by a wave of medical breakthroughs (PD-1, HCV, CAR/TCR, oral MS drugs, CF etc.). These waves typically involve new therapeutic approaches coupled with disruptive technologies as their enablers.

In oncology, for example, the understanding that cancer is driven by aberrant signaling coupled with advances in medicinal chemistry and antibody engineering led to the development of kinase inhibitors and monoclonal antibodies as blockers of signaling. A decade later, insights around cancer immunology gave rise to the immuno-oncology field and PD-1 inhibitors in particular, which are expected to become the biggest oncology franchise ever.

Gene therapy ticks all the boxes

While there are several hot areas in biotech such as gene editing and microbiome, most are still early and their applicability is unclear. Gene therapy, on the other hand, is more mature and de-risked with tens of clinical studies and the potential to treat (and perhaps cure) a wide range of diseases where treatment is inadequate or non-existent. The commercial upside from these programs is huge and should expand as additional indications are pursued.

As I previously discussed, the past two years saw a surge in the number of clinical-stage gene therapies, some of which already generated impressive efficacy across multiple indications. This makes gene therapy the only truly disruptive field which is mature enough not only from a technology but also from a clinical standpoint. Importantly, most studies are conducted by companies according to industry and regulatory standards, in contrast to historical gene therapy studies that were run by academic groups.

To me, the striking thing about the results is the breadth of technologies, indications and modes of administrations evaluated to date. This versatility is very important for the future of gene therapy as it reduces overall development risk and increases likelihood of success by allowing companies to tailor the right product for each indication. Parameters include mode of administration (local vs. systemic vs. ex vivo), tropism for the target tissue (eye, bone marrow, liver etc.), immunogenicity and onset of activity.

Building a diversified gene therapy basket

Given the early development stage and large number of technologies, I prefer to own a basket of gene therapy stocks with a focus on the more clinically validated ones: Spark (ONCE), Bluebird (BLUE) and Avexis (AVXS).

Bluebird and Spark are the most further along (and also the largest based on market cap) gene therapy companies and should be the basis for any gene therapy portfolio. With two completely different technologies, the two companies have strong clinical proof-of-concept for their respective lead programs.

Avexis is less advanced without a clinically validated product, but recent data for its lead program are too promising to ignore.

Spark Clinical validation for retinal and liver indications

Sparks lead programs (SPK-RPE65) will probably become the first gene therapy to get FDA approval. In October, the company reported strong P3 data in rare genetic retinal conditions caused by RPE65 mutations, the first randomized and statistically significant data for a gene therapy. The company is expected to complete its BLA submission later in 2016 which should lead to FDA approval in 2017. Sparks second ophthalmology program for choroideremia is in P1 with efficacy data expected later in 2016.

Earlier this month, Spark released an encouraging update for its Hemophilia B program, SPK-9001 (partnered with Pfizer [PFE]). A single administration of SPK-9001 led to a sustained and clinically meaningful production of Factor IX, a clotting factor which is dysfunctional in Hemophilia B patients. All four treated patients experienced a clinically significant increase in Factor IX activity from <2% to 26%-41% (12% is predicted to be sufficient for minimizing incidence bleeding events). Due to the limited follow up (under 6 months), durability is still an open question.

Spark intends to advance its wholly-owned Hemophilia A program (SPK-8011) to the clinic later in 2016 with initial data expected in H1:2017. Results in the Hemophilia B should be viewed as a positive read-through but Hemophilia A still presents certain technical challenges (e.g. missing protein is several fold larger) which required Spark to use a different vector. Hemophilia A represents a $5B opportunity compared to $1B for Hemophilia B.

Bluebird

Despite being one of the worst biotech performers, Bluebird remains the largest and most visible gene therapy company. In contrast to most gene therapy companies, Bluebird treats patients cells ex-vivo (outside of the body) in a process that resembles stem cell transplant or adoptive cell transfer (CAR, TCR). Progenitor cells are collected from the patient, a genetic modification is integrated into the genome followed by infusion of the cells that repopulate the bone marrow. This enables Bluebird to go after hematologic diseases like beta thalassemia and Sickle-cell disease (SCD) where target cells are constantly dividing.

Sentiment around Bluebirds lead program, Lenti-globin , plummeted last year after a series of disappointing results in a subset of beta-thal patients and preliminary data in SCD, which represents the more important commercial opportunity. Particularly in SCD patients, post-treatment hemoglobin levels were relatively low and although some increase has been noted with time, it is still unclear what the maximal effect would be. Market reaction was brutal, sending shares down 75% in just over a year.

Next update for Lenti-globin is expected at ASH in December. Despite the disappointing efficacy observed in SCD and beta-thal, I am cautiously optimistic about Bluebirds efforts to optimize treatment protocols and regimens. These include specific conditioning regimens and ex-vivo treatment of cells that may improve transduction rate and hemoglobin production in patients. Some of these modifications are already being implemented in newly recruited patients and hopefully longer follow up will lead to higher hemoglobin levels in already-reported patients.

The only clinical update so far in 2016 was for Lenti-D in C-ALD, a rare neurological disease that affects infants in their first years. Results demonstrated that of 17 patients treated to date (median follow-up of 16 months), all remain alive and free of major functional deterioration (defined as major functional disabilities, MFD). The primary endpoint, defined as no MFD at 2 years, was reached for 3/3 patients with sufficient follow-up and assuming the trend continues Bluebird may be in a position to file for approval in H2:2017.

Lenti-Ds commercial opportunity is limited (200 patients diagnosed each year in developed countries) so investors understandably focus on Lenti-globin, which is being developed for beta thal (~20k patients in developed countries) and SCD (~160k patients).

Bluebird is expected to end 2016 with ~$650M in cash. Current market cap is $1.7B.

Avexis

Avexis is developing AVXS-101 for Spinal muscular atrophy Type 1 (SMA1), a rapidly deteriorating and fatal neuro-muscular disease. SMA1 is characterized by rapid deterioration in motor and neuronal functions with 50% of patients experiencing death or permanent ventilation by their first anniversary. Most patients die from respiratory failure by the age of two. SMA Type 2 and Type 3 are also caused by SMN1 mutations and are characterized by a later onset and milder disease burden (but unmet need is still significant in these indications). The US prevalence of SMA is 10,000, 600 of which are SMA1.

In contrast to Bluebird and Spark, Avexis does not have conclusive proof it can lead to expression of the missing protein (SMN1) in the target tissue nor does it have randomized clinical data but the results generated to date are simply too provocative to ignore.

At the most recent update, Avexis presented data for 15 patients who received AVXS-101 in their first months of life. 3 patients were treated with a low dose and 12 were treated with a high dose. Strikingly, none of the children experienced an event (defined as ventilation or death), including patients who reached 2 years of age. All 9 patients with sufficient follow up, reached the age of 13.6 months without an event in contrast to historical data that show an event-free survival of 25%. AVXS-101 also led to a dose dependent increase in motor function which had a quick onset especially at the higher dose.

As with any results from an open label study without a control arm, these data should be analyzed with caution, as they need to be corroborated by large controlled studies (expected to start next year). Still, the data point to an overwhelming benefit in a very aggressive disease. One of the most exciting aspects of this program is the fact that it is given systemically via IV administration, which implies the treatment reaches the neurons in the CNS. Avexis plans to start a trial in SMA2 in H2:16 using intrathecal delivery (directly to the spinal canal). This decision is surprising given the results with IV administration in SMA1 and the fact that the BBB immaturity hypothesis in babies is not considered relevant anymore. (See this review)

AVXS-101s main competitor is Biogens (BIIB) and Ionis (IONS) nusinersen, an antisense molecule that needs to be intrathecally injected 3-4 times a year. As both drugs generated encouraging clinical data in small non-randomized studies, it is hard to compare them, however, AVXS-101 has an obvious advantage of being a potentially one time IV injection. Nusinersen is in P3 with topline data expected in mid-2017.

AVXS-101 is based on an AAV9 vector developed by REGENXBIO (RGNX), which licensed the technology to Avexis. Beyond the 5%-10% in royalties REGENXBIO is eligible to receive, data for AVXS-101 bode well for the companys proprietary programs in MPS-I and MPS-II, two other rare diseases with neurological involvement where BBB penetration is crucial. These programs are also based on REGENXBIOs AAV9.

Beyond AVXS-101, REGENXBIO has an impressive partnered pipeline which includes collaborations with Voyager (VYGR), Dimension (DMTX) , Baxalta and Lysogene.

Portfolio updates Immunogen, Marinus, Esperion

June was a rough month for three of my holdings. Immunogen (IMGN) had a disappointing data set at ASCO, Marinus (MRNS) reported a P3 failure in epilepsy and most recently, Esperion was dealt a regulatory blow from the FDA that may push development timelines by several years. I am selling Immunogen and Marinus due to the lack of near-term catalysts although long-term their respective drugs could still be valuable. I decided to keep Esperion as I still find ETC-1002 very attractive and hope that PCSK9s CVOT data will soften FDAs concerns about LDL-C reduction as an approvable endpoint.

Three additional companies with important binary readouts in the coming months are Array Biopharma (ARRY), SAGE (SAGE) and Aurinia (AUPH). Array will have P3 data for selumetinib (partnered with AstraZeneca) in KRAS+ NSCLC. SAGE will report data from a randomized P2 in PPD following a promising single-arm data set. Aurinia will report results from the AURA study in lupus nephritis patients, where there is a strong rationale for using the companys drug (voclosporin) but limited direct clinical validation.

Portfolio holdings July 4, 2016

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Could gene therapy become biotechs growth driver in 2017 ...

The Official Travel and Tourism Website for North Carolina

Whether you're looking for scenic tours, cultural attractions, outdoor adventure or great local food and drinks, weve got you covered.

Enjoy glowing gardens, festive neighborhoods, decorated downtowns, star-bright boat parades and even Christmas lights around a racetrack.

No matter where you're visiting in North Carolina for the holidays, youll find an array of hotels, bed-and-breakfasts, resorts and cabins nearby.

Visit our winter sports resorts to enjoy the highest ski peak in the East and the gentlest of beginner slopes.

Say hello to 2017 at some of our states most popular New Years Eve and Day events, from festivals to parties to first-day hikes.

Searching for more things to see and do on your next visit to North Carolina? Browse by interest

From one-day jaunts to weeklong adventures, these trip ideas will inspire families, foodies and outdoor enthusiasts alike.

Durham is one of the hottest food cities in the country, so round up your friends for a trip filled with good eats, nights out, and stays at boutique hotels.

Bootleggers once ran illegal spirits here, but today North Carolina has several legal distilleries around which you can plan a weekend.

In between rounds of golf in Beaufort, Morehead City and Emerald Isle, take strolls on quiet beaches, tour an old pirate ship or see wild horses roam.

Stretching along our coast, the Outer Banks offers vacation amenities that stretch as far as your imagination especially when you stay at Sanderling Resort.

Want more North Carolina vacation ideas? See additional day trips and getaways

Search seasonal festivals, wine and food events, local music, cultural happenings and more.

Belmont

November 18 - January 1, 2017

Mill Spring

December 17 , December 24

Lake Lure

January 1, 2017

See the rest here:

The Official Travel and Tourism Website for North Carolina

Astronomy Cast

Were fitting in one more episode this week, before Fraser heads off to Costa Rica for a week. Our next episode will record on Dec. 23, 2016. We usually record Astronomy Cast every Friday at 1:30 pm Pacific / 4:30 pm Eastern / 8:30 PM UTC (20:30 GMT). You can watch us live on AstronomyCast, []

Join us as we try to finish the interrupted episode Coming Home from Mars! Landing on the surface of Mars is very difficult. In fact, its probably the toughest planet to land on in the whole Solar System. Today well talk about what its going to take to get to and return from Mars! We []

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Hey folks, just letting you know that due to Fraser being at conference this week, we wont be recording an Astronomy Cast any time. Unfortunately, our last show was interrupted by a power outage, and well try to get back together to finish that one on Monday, 12/5. We will keep you posted as info []

Note This episode was interrupted due to a power outage on Frasers end. Theyll reschedule to finish episode on 12/5 (most likely Fraser is traveling this week!), and well put the pieces together when we have them and release as audio podcast! Landing on the surface of Mars is very difficult. In fact, []

When Elon Musk announced plans to send humans to Mars, he conveniently left out one important aspect. How are we supposed to survive on a place this hostile to life? Seriously, Mars sucks, and its going to take some impressive techniques and technologies to make it on the Red Planet. We usually record Astronomy Cast []

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We begin a miniseries on Mars. How many episodes will we do? Who knows? But we start today with a discussion of the two Mars moons, Phobos and Deimos. We usually record Astronomy Cast every Friday at 1:30 pm Pacific / 4:30 pm Eastern / 8:30 PM UTC (20:30 GMT). You can watch us live []

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Did you hear that Dark Energy doesnt exist any more? Neither does Dark Matter? It turns out that NASA recalculated the Zodiac and now youre an Ophiuchan! Science is hard enough, but communicating that science out to the public when there are publications hungry for traffic is even harder! Heres how to parse the click-bait []

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I hate to tell you this, but that meat computer in your skull is constantly betraying you. Dont worry, weve all got the same, but fortunately, scientists have learned how this happens, and can help us make sure our science, and lives dont suffer because of it. (more)

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Have you ever noticed spacecraft missions have some pretty cool names? How does anyone decide what to call these things? (more)

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It turns out that nature figured out how to use electricity long before humans did. Lightning storms are common across the Earth, and even the Solar System. What causes this electricity in the sky, and how can science use it? We usually record Astronomy Cast every Friday at 1:30 pm Pacific / 4:30 pm Eastern []

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Astronomy Cast

Euthanasia – The New York Times

Latest Articles

Fewer people experience a natural death anymore. Doctors should rethink their opposition to right-to-die laws.

By HAIDER JAVED WARRAICH

Proponents say there are valid reasons besides terminal illness to choose to die, among them loss of independence, deterioration and loneliness.

New York, the District of Columbia and Colorado could join the jurisdictions where doctors may assist terminally ill patients to die with dignity.

By THE EDITORIAL BOARD

The law, which took effect on June 9, will not be blocked now, but the judge agreed to allow a lawsuit challenging the measure to go forward.

The magazines Ethicist columnist on how to make a hard decision about an old dog before a stressful trip and weighing politeness against public health when it concerns a contagious child.

By KWAME ANTHONY APPIAH

As the state begins to allow what has come to be known as aid in dying, two patients and two doctors explain how it will affect them and how they are preparing for the changes.

By JENNIFER MEDINA

Canadas Supreme Court overturned criminal laws banning assisted suicide last year, and new legislation has not been put into place.

By IAN AUSTEN

Advocates on both sides of the issue respond.

Its important to provide a humane option to the dying. Its also essential that people have access to palliative and hospice care.

By THE EDITORIAL BOARD

On Thursday, Prime Minister Justin Trudeau of Canada unveiled a new bill that would legalize doctor-assisted suicides for people suffering from serious medical ailments.

By REUTERS

The prime minister has introduced legislation to address the legal void left after Canadas Supreme Court overturned a ban on doctor-assisted death.

By IAN AUSTEN

Researchers who looked at doctor-assisted deaths in the Netherlands found that some patients had declined treatment that might have helped.

By BENEDICT CAREY

Doctors, it turns out, arent much different than everyone else when it comes to where they die.

By DANIELLE OFRI, M.D.

Although Mr. Hooker repeatedly lost his races for elective office in Tennessee, he managed to advance a progressive agenda through his candidacies and as a plaintiff.

By SAM ROBERTS

The magazines ethicist on a siblings struggle, favors in the workplace and secrets between friends.

By KWAME ANTHONY APPIAH

Shared Belief, a gelding, won 10 of 12 career starts and had earnings of more than $2.9 million.

As Holocaust survivors, my parents insisted on being in control of their own deaths.

By ANN M. ALTMAN

When it comes to the end of life, what role should patients play in deciding the terms of their own death?

By SUSAN GUBAR

A son in Colombia helps his mother die while making plans of his own.

CARLOS FRAMB

Un hijo ayuda a su madre enferma y enfrenta su propio destino

CARLOS FRAMB

Fewer people experience a natural death anymore. Doctors should rethink their opposition to right-to-die laws.

By HAIDER JAVED WARRAICH

Proponents say there are valid reasons besides terminal illness to choose to die, among them loss of independence, deterioration and loneliness.

New York, the District of Columbia and Colorado could join the jurisdictions where doctors may assist terminally ill patients to die with dignity.

By THE EDITORIAL BOARD

The law, which took effect on June 9, will not be blocked now, but the judge agreed to allow a lawsuit challenging the measure to go forward.

The magazines Ethicist columnist on how to make a hard decision about an old dog before a stressful trip and weighing politeness against public health when it concerns a contagious child.

By KWAME ANTHONY APPIAH

As the state begins to allow what has come to be known as aid in dying, two patients and two doctors explain how it will affect them and how they are preparing for the changes.

By JENNIFER MEDINA

Canadas Supreme Court overturned criminal laws banning assisted suicide last year, and new legislation has not been put into place.

By IAN AUSTEN

Advocates on both sides of the issue respond.

Its important to provide a humane option to the dying. Its also essential that people have access to palliative and hospice care.

By THE EDITORIAL BOARD

On Thursday, Prime Minister Justin Trudeau of Canada unveiled a new bill that would legalize doctor-assisted suicides for people suffering from serious medical ailments.

By REUTERS

The prime minister has introduced legislation to address the legal void left after Canadas Supreme Court overturned a ban on doctor-assisted death.

By IAN AUSTEN

Researchers who looked at doctor-assisted deaths in the Netherlands found that some patients had declined treatment that might have helped.

By BENEDICT CAREY

Doctors, it turns out, arent much different than everyone else when it comes to where they die.

By DANIELLE OFRI, M.D.

Although Mr. Hooker repeatedly lost his races for elective office in Tennessee, he managed to advance a progressive agenda through his candidacies and as a plaintiff.

By SAM ROBERTS

The magazines ethicist on a siblings struggle, favors in the workplace and secrets between friends.

By KWAME ANTHONY APPIAH

Shared Belief, a gelding, won 10 of 12 career starts and had earnings of more than $2.9 million.

As Holocaust survivors, my parents insisted on being in control of their own deaths.

By ANN M. ALTMAN

When it comes to the end of life, what role should patients play in deciding the terms of their own death?

By SUSAN GUBAR

A son in Colombia helps his mother die while making plans of his own.

CARLOS FRAMB

Un hijo ayuda a su madre enferma y enfrenta su propio destino

CARLOS FRAMB

Read more:

Euthanasia - The New York Times