How Mindfulness Can Lead to Better Health Care Outcomes – Knowledge@Wharton

The term mindfulness is increasingly an integral part of the health care vocabulary as more medical practitioners discover how it helps create better treatment outcomes. Mindfulness clearly is a wave across the country, saysRonald Epstein, a physician and professor of family medicine, psychiatry and oncology at the University of Rochester Medical Center. He details his ideas in his recent book, Attending: Medicine, Mindfulness, and Humanity, which he discussedon the Knowledge@Wharton showon Wharton Business Radio on SiriusXM channel 111. (Listen to the podcast at the top of this page.)Below is an edited transcript of the interview.

Knowledge@Wharton: Why hasnt mindfulness been a part of medical science?

Ronald M. Epstein: It has and it hasnt. There are references to it [one can trace] even to the ancient Greeks. There were statements saying that a doctor needs to know a patient through and through in order to better take care of them. That has always been an undercurrent in medicine, because were so focused on other people on patients, and on people who are suffering.

Knowledge@Wharton: What was the tipping point to write this book now?

Epstein: Mindfulness and self-awareness were always a part of my life from a very young age. But it wasnt until Id been in practice for about 10 years that I realized that this was a fundamental and missing ingredient in medical education and medical practice, and that the public needed to hear about it.

Knowledge@Wharton: In terms of it being a missing ingredient from medical education, is it something that many institutions are realizing now, and are they starting to incorporate it?

Epstein: [That is occurring] more and more. Most medical schools now have at least an elective opportunity for medical students to participate in some kind of mindfulness workshop or a mindfulness course. At a few medical schools, including ours, [that is part of] required content for all students. As people go on through training, there are more and more opportunities for practicing physicians to learn to be more mindful, to be more attentive, and to be more present. It clearly is a wave across the country.

Its not that you just do mindfulness, or sit on a cushion, or do meditation, or take a mindful attitude, but it becomes a habit.

Knowledge@Wharton: This has been in your mind for quite some time. In fact, you lay out instances such as when you were going through your learning stages as a doctor, of other doctors that you saw making mistakes.

Epstein: They were big and obvious mistakes. When I was a third-year student, I noticed a physician who ignored something that was completely obvious within the operating field, partly because it was surprising. It was something that he wasnt expecting. It reminded me many years later of that video thats gone viral, where people are playing basketball, and then a gorilla comes across the screen, and half the people dont even see the gorilla.

This invisible gorilla in medicine is not only in the operating room, but also in the clinic. I noticed that doctors pay attention to certain symptoms more than others. They tend to ignore things that later seem obvious and are often keys to understanding whats going on with patients.

Knowledge@Wharton: This is obviously something that varies from doctor to doctor, and some are more aware of it than others.

Epstein: I think so. Its really an ability to be aware of yourself while being aware of whats going on outside.

Knowledge@Wharton: My kids are 10 and eight years old and have a mindfulness class in school this year, which caught me off guard. Is this push to bring mindfulness forward something that were seeing in many different places?

Epstein: Yes, my kids, too, [had such a class] when they were in elementary school. They were in somewhat of an alternative school setting, but they clearly had mindfulness content. Increasingly, in education, this is viewed as something important, because learning is about knowing your own mind and how it works, how you take in information, how you process information, and what biases you have. I would extend that to everything that you do in life. In your work setting, in terms of relationships, knowing yourself is important.

Knowledge@Wharton: Many people would say that being able to deal with not-so-normal situations, especially when youre younger, will help you as you get through college and head out into the business world.

Epstein: I think of these as habits of mindfulness. Its not that you just do mindfulness, or sit on a cushion, or do meditation, or take a mindful attitude, but it becomes a habit. It becomes the way that you deal with the world in general.

Knowledge@Wharton: In your research, you mention experiences with Zen Buddhism in understanding mindfulness better.

Epstein: My interest in the mind goes back to when I was a teenager and I studied Zen Buddhism. I eventually ended up at a Zen center in California for a few months, which was a formative time for me. I brought not only the practice the practicality of doing lots of sitting meditation may or may not appeal to people but the underlying attitude towards ones own mind, the possibility of knowing ones self better and using that self-knowledge to be more effective and more compassionate.

Knowledge@Wharton: Theres an interesting line in the book Doctors are trained to cling to categories. Obviously, a part of that is that doctors have specialties and they follow that path. But it sounds like doctors can be their own worst enemy in terms of maybe [diagnosing] a potential disease.

Epstein: Absolutely, and this is one of the biggest problems in diagnostic errors. In psychology they call it premature closure. That is, you find a set of symptoms, grab at the first thing that seems to fit with those symptoms, and then your mind closes even if theres disconfirming data, and even if things dont continue to add up.

I tell a couple of stories in the book that exemplify that. A friend of mine had bladder cancer and had a catheter put in. The catheter was removed, and later he was found not to be urinating normally. He went to an emergency room. It was a hot day, and the emergency room doctors thought that he must be dehydrated. Heres a relatively young, fit-looking guy whos not peeing very much. So they started an IV and gave him more and more and more fluid, not recognizing the fact that he had just had bladder surgery, and there might be an obstruction. In fact, that was the case, but it took three changes of shift and about 18 hours of IV fluids before anyone realized it.

Knowledge@Wharton: Are you able to determine, through your research for this book and maybe other studies, the impact we may have from not having this approach of mindfulness among doctors and nurses, and the health care sector in general? I would think if youre making these mistakes, there is obviously an economic impact that will happen patient by patient.

Epstein: I cant even begin to calculate what the economic impact would be. But I do know what the human impact would be for each patient, if they feel that theyve not been understood and the treatment theyre receiving is not necessarily the ideal treatment for what [medical condition] they have. It really just takes once to have an experience like that.

Im a practicing family physician, and in family medicine, probably you encounter more ambiguity than in other areas of medicine, just because people can come in with anything. Im humbled every day, realizing that its a very inexact science that Im practicing. Its a human endeavor and with some scientific trappings, if you will.

But adopting that sense of not knowing, and that sense of humility, in some ways is very protective, because then Im always not too sure of myself. Im sure of myself; Im confident. Ive been in practice for a number of years, but Im not so sure of myself that the door to other possibilities is closed.

Health care has become much more productivity-oriented and less of a human enterprise.

Knowledge@Wharton: It has to be a challenge, when most of the people you treat have the expectation that this is a perfect science.

Epstein: What youre saying is absolutely true. When Im a patient, I want things to be exact and perfect, and everything to go smoothly. But the reality is that thats a desirable goal but not achievable 100% of the time.

Knowledge@Wharton: I guess this filters down to other people within the hospital structure, as well.

Epstein: Absolutely, and it filters down to anyone whos in a high-risk profession. It would filter down to air traffic controllers. It would filter down to police officers and the military anyone who has to make judgments under uncertainty.

Knowledge@Wharton: You mention that were seeing a higher rate of doctors either leave this field because of burnout, or they change what they are doing within the medical field. That is a concern that the medical industry has to continue to deal with on a day-to-day basis.

Epstein: The degree to which health care professionals are burned out affects the quality of care that they provide. This has been proven over the past 20 years, and it clearly is a connection. The burnout problem is not just about the well-being of clinicians, but its also really about the safety of the public. When you think about that, having a resilient and self-aware and engaged health care workforce is in everybodys best interest.

Two things have happened over the past 10 or 15 years. One is that health care has become much more productivity-oriented and less of a human enterprise. No one goes into medicine to be working on an assembly line. People go into medicine because they like people, and they enjoy the interactions they have with people. [But] were spending less and less of our time face-to-face with people and more and more of our time doing administrative tasks. Some of those administrative tasks are related directly to the computerization of medical records.

Knowledge@Wharton: Can this at times be a learned experience, as well to be able, to a degree, to change your mindset as a doctor so that you are more aware of this?

Epstein: I see this as an individual enterprise, as well as a collective one. On an individual level, for example, I know that what I enjoy about seeing patients is face-to-face contact, so I dont even turn the computer on until the patient and I have had a couple of minutes to talk face-to-face, without a computer screen.

Thats a personal decision Ive made, because thats what gives me satisfaction at work, and it makes a big difference for me. However, health care institutions have a huge responsibility because in the design of health care, they have not taken human factors into account. They have not taken into account the degree to which we can assimilate information. Theyve not taken into account the fact that multitasking is impossible that we alternate between tasks. We dont do two things at the same time. And they dont take into account what gives patients and physicians the most satisfaction about their visits. Its about having real conversations.

Knowledge@Wharton: What are some of the things that you would like to see incorporated in medical education to better prepare doctors and nurses for this?

Epstein: Some of these things are really simple. There are courses in communicating with patients, but theres no education in how to prepare yourself psychologically for a potentially difficult encounter that you might have with a patient or even a routine one. I teach medical students, resident [doctors] and practicing physicians simple things, like when your hand is on the door handle and about to go into the patients room, what do you do? You can use that as a mindful moment. You can take a breath. You can mentally set aside whats happened before with a previous patient. You can practice presence. You can practice being present. The more you do this, the more it becomes second nature, so that each time you enter a patients room, your mind is just that much more fresh, more open, more receptive and the patient sees that youre present that youre really there.

If you can recognize when youre beginning to burn out and what those signs are, then you can begin to take action before things get out of hand.

Knowledge@Wharton: You also talk about how these approaches can help health care systems.

Epstein: Yes, and some health systems have done this mindfully, and others have not. Some systems are actively looking at patients experience and clinicians experience of care. Other systems are taking a production-oriented approach, in which physicians and other health care professionals are viewed as merely widgets in a very large machine.

Knowledge@Wharton: What is it that doctors and nurses need to be aware of? You have a chapter in the book called Healing the Healer.

Epstein: The first step for anyone in a high-stress profession is to recognize the earliest warning signs they have that theyre beginning to burn out. So for someone it might be a headache. For someone else, it might be a sense of an upset stomach. For some people, it may be feeling tired. Some people might not sleep as well. Some people might make more typos when theyre typing on the computer. If you can recognize when youre beginning to burn out and what those signs are, then you can begin to take action before things get out of hand. Its a collection of these simple actions that you can take during the workday that can make a difference.

Sometimes the solutions are simple, like just reminding yourself to slow down or finding a quieter place to work, where youre less likely to be distracted or taking a break, or doing something to help you connect better to your work.

Knowledge@Wharton: It could be just as simple as realizing youre at a point where you need to take a vacation or a couple of days.

Epstein: Absolutely, or even a mini-vacation. If I finish seeing patients at 7:00 at night, and Im exhausted and beginning to see double, Ill say, Well, wait a second. Finishing these charts I could try to do this now and possibly risk making some errors, or I could just leave it until early the next morning and finish them then. Without that awareness, you keep plowing ahead, and you feel worse about yourself, and the work that you do is of lower quality. So its just about becoming aware. I call it turning towards, because it means that these are not pleasant feelings, when youre beginning to feel burned out. But if you push them away and dont acknowledge them, its just going to get worse.

Knowledge@Wharton: You talk about doctors being able to practice compassion.

Epstein: I think compassion takes work. I believe that humans fundamentally have a compassionate side, but when youre dealing with suffering and tragedy, sometimes it feels too much to take that in, and you create a wall. We often forget that by creating a wall, we actually need energy to create that wall, and that energy becomes exhausting. So it may seem that its self-protective and trying to preserve yourself, but creating walls like that just sometimes makes matters worse. Now this doesnt mean that you dont need time for yourself, that you dont need space. Thats important, as well. But recognition is the first thing. The second is that there are exercises you can do to learn to be more compassionate.

In a research study that is ongoing at Duke University, they ask people to write down every day three things for which they feel grateful. Just the act of writing those things down helps you its more energizing. It makes you realize what you have and others dont, and creates what are called more pro-social attitudes attitudes that are concerned with the welfare and well-being of other people.

Knowledge@Wharton: It sounds like you have had to take the course Physician, heal thyself from time to time, as well.

Epstein: We all do. Yes, thats the little secret. We all do.

See the original post here:

How Mindfulness Can Lead to Better Health Care Outcomes - Knowledge@Wharton

What Health Care Barriers Have You Faced As A Black Trans Person? – BuzzFeed News

Your Post Has Been Launched!

Fabulous! Don't forget to share with your friends on Twitter and Facebook.

We want to hear your stories.

And its not for a lack of trying, either.

ID: 10528166

ID: 10528360

ID: 10528729

Shoot, maybe you dont even have insurance, which means you cant get the health care you really need.

ID: 10536520

Maybe they refused to use your preferred pronoun or made sweeping generalizations without ever actually asking about your lifestyle.

ID: 10528689

Maybe they said snide or even outright mean things to you. And because of this mistreatment, you knew that place wasnt the right one for you even if it was just to get checked up for a nagging cough or an eye exam. Maybe such an instance even forced you to travel two hours now just to see someone whos trans-friendly and knows what theyre doing.

ID: 10528578

If so, please share your secrets with the class.

ID: 10532364

You can submit your story (anonymously, if you want to) in the form below. You can also view the form here, which might be easier on mobile. Please share as much detail as you can vent to us! The more we know about your experience, the more likely it is that we can include you in a future post. Your story, whether related or unrelated to transition, could help other people with their own medical struggles.

ID: 10529123

Check out more articles on BuzzFeed.com!

Facebook Conversations

Your Reaction?

Sorry, but you can only react up to 3 times!

Oops! It looks like you've already used that reaction on this post.

You are signed in as .

I know, right? Will your friends agree?

Share this Link

What Health Care Barriers Have You Faced As A Black Trans Person?

Tagged:add yours, black andtrans, black transhealth, black transperson, discrimination, doctor, estrogen, harassment, health, health care, healthcare, hormone therapy, medical care, medicine, progesterone, seeing adoctor, surgery, testosterone, top surgery, trans, trans healthcare, trans healthcare, trans medicine, transgender, transition, collection

Facebook Conversations

Choose a new image Save Save Thumbnails Preview Thumbnails

Please select the newsletters you'd like to receive.

Your email has been sent!

Thanks for sharing! You should sign up for our Daily newsletter!

Oops! We had a problem sending your message. Please try again later.

Great! You'll get your first email soon.

Excerpt from:

What Health Care Barriers Have You Faced As A Black Trans Person? - BuzzFeed News

Bay Area political events: Health-care town hall, anti-Trump rallies – SFGate

By Sarah Ravani, San Francisco Chronicle

Photo: Justin Sullivan, Getty Images

A worker passes out American flags during a naturalization ceremony Wednesday held by U.S. Citizenship and Immigration Services at the Los Angeles Convention Center.

A worker passes out American flags during a naturalization ceremony Wednesday held by U.S. Citizenship and Immigration Services at the Los Angeles Convention Center.

Bay Area political events: Health-care town hall, anti-Trump rallies

Political events

in the Bay Area

Friday

Anti-Trump rally and march: Justin Herman Plaza in San Francisco at 5 p.m., organized by Answer Coalition.

Saturday

Anti-Trump demonstration: A gathering under the awning of the Grand Lake Theatre, 3200 Grand Ave., Oakland, from 12 to 1 p.m. to bring attention to racial-injustice issues.

Town hall on health care: Hosted by Democratic Reps. Mark DeSaulnier of Concord, Mike Thompson of St. Helena and Jerry McNerney of Stockton, from 10:30 a.m. to noon. On the agenda are the Affordable Care Act, Medicare and Medicaid. Contra Costa County Board of Supervisors chambers, Room 107, 651 Pine St., Martinez.

Sunday

Day of remembrance: Groups in San Francisco and San Jose are holding a day of remembrance marking the 75th anniversary of Executive Order 9066, which resulted in the incarceration of Japanese Americans in internment camps in World War II. AMC Kabuki 8 Cinemas, 1881 Post St., San Francisco, 2 p.m. San Jose Buddhist Church Betsuin, 640 N. Fifth St., 5:30 p.m.

Monday

Anti-Trump rallies: Not My President rallies in San Francisco, at noon in Justin Herman Plaza; outside San Jose City Hall at 200 E. Santa Clara St. at 10 a.m.; and on the sidewalk of the 300 block of El Camino Real in San Mateo at 4:30 p.m.

Thursday

Town hall: Hosted by Rep. Mark DeSaulnier, D-Concord, from 6:30 to 8 p.m. at Diablo Valley College cafeteria, 321 Golf Club Road, Pleasant Hill.

Feb. 26

New women activist brunch: Meet and greet for women and members of womens organizations working to elect progressive, pro-abortion rights women to office. Hosted by Democratic Activists for Women Now, 11 a.m. to 3 p.m., 2302 Zanker Road, San Jose.

Anti-Trump planning meeting: Activists organizing to resist the Trump administration will hold a general meeting from 7:30 to 9:30 p.m. at the Finnish Hall, 1970 Chestnut St., Berkeley.

To list an event, email Sarah Ravani at sravani@sfchronicle.com

View original post here:

Bay Area political events: Health-care town hall, anti-Trump rallies - SFGate

Nigerians Pay for Leaders’ Treatment Abroad, Get Little Health Care at Home – Voice of America

JOHANNESBURG

Nigerian President Muhammadu Buharis nearly monthlong medical leave in London is a sharp reminder to taxpayers that while they finance their leaders health care abroad, they often are stuck with decrepit, ill-staffed government health facilities at home.

For decades, Nigerians have paid for their leaders and former rulers to get medical treatment overseas. That courtesy also extends to senior government employees.

This is despite taxpayers funding of the State House Medical Center, said to be Nigerias best-equipped facility, which serves the president and vice president, their families and staff. The centers budget this year of 3.8 billion naira to care for fewer than 1,000 people represents 1 percent of the entire public health budget for the countrys 170 million people.

For years, billions have been budgeted for the State House Medical Center while it has always been evident that every president mostly accessed medical facilities outside the country, going back to the 1980s, said Oluseun Onigbinde, co-founder of BudgIT, an organization that tries to bring clarity to the West African nations opaque budget.

Anti-government protesters hold flags as they march in Abuja, Nigeria, Feb. 9, 2017.

Recession at home

The mysterious nature of Buharis absence is adding to the unhappiness at home, as one of Africas largest economies and oil producers lurches through a recession.

His government has not said what exactly his health issues might be or when he will return. The presidents trip, originally scheduled from January 20 to February 6, was described as a vacation during which he would undergo routine medical tests. It has been extended for further tests.

Officials insist that Buhari is hale and hearty, and he was well enough this week to speak by telephone with U.S. President Donald Trump.

Human rights lawyer Femi Falana said Nigerians should seize on the presidents medical leave to demand adequate funding for public hospitals he described as mortuaries for the masses.

The practice of allowing poor citizens to die of preventable diseases while top public officers and rich private citizens are allowed to travel abroad for medical treatment can no longer be justified, he said in a lecture this week, noting that Nigerians have a life expectancy of 52 years.

Medical bills add up

It is not clear how much the countrys taxpayers pay for leaders treatments abroad.

Former first lady Patience Jonathan has claimed that half of $31.5 million frozen in a corruption investigation was a government payout for medical bills she incurred in London in 2013. Ever-witty Nigerians took to social media to ask if she was buying eternal life.

The Ministry of Health estimated that Nigeria paid about $1 billion for government officials traveling abroad for medical care in 2014, with ordinary Nigerians spending about $6.3 billion in 2015 for what is called medical tourism.

Senior Nigerian officials get high yearly allowances for health care abroad, which provides them opportunity to demand amounts to take care of their non-health care needs like shopping abroad, economist Vitalis Chi. Nwaneri wrote in his 2013 book Governing the Ungovernable.

Former military dictator Gen. Ibrahim Babangida returned home this month from a six-week medical vacation in Switzerland. Last year, he was treated for weeks in Germany.

Taxpayers also footed the bill when former President Umaru YarAdua received months of medical treatment in Saudi Arabia in 2008-2009, before he returned home to die in office.

Best Nigerian clinic not enough

In April, Buhari announced that his government would no longer pay for officials to travel abroad for medical services available at home. But two months later, the president was in London for treatment of an ear infection.

The best-funded clinic in Nigeria does not suffice to treat the presidents ear infection. Nor does the president have enough confidence in the same clinic to do his routine checkups there, novelist Okey Ndibe wrote at saharareporters.com .

Imagine, then, the fate of Nigerians who have no choice but must seek treatment at the ill-equipped, wretchedly funded hospitals in our country? he asked.

Nigeria has just five hospital beds and not even one doctor for every 100,000 people, as opposed to an average of 35 beds and 24 doctors per 100,000 in South Africa, which has the continents most advanced medical care, according to a PricewaterhouseCoopers study in 2015.

Nigerians who can afford it shun even private health care at home.

Because the country has one of the worlds worst infant and maternal mortality rates, women fly to the United States and Britain to have babies safely delivered. The risk of a woman dying because of pregnancy or childbirth in Nigeria is one in 15, compared to one in 5,000 in developed nations, according to Dr. Chris Akani, professor of obstetrics and gynecology at Nigerias College of Health Sciences at the University of Port Harcourt.

Buharis medical bills do not come with a bed at a heftily priced five-star hotel, as did those of predecessors. The 74-year-old anti-corruption crusader known for his simple lifestyle is staying at the residence of the Nigerian High Commission in London, a spokesman said.

Read more here:

Nigerians Pay for Leaders' Treatment Abroad, Get Little Health Care at Home - Voice of America

Genetic basis for male baldness identified in large-scale study – Medical News Today

Although common, male baldness can have negative psychological effects and some studies have even linked it to a handful of serious illnesses. New research identifies the genetic variants involved in the condition, which could eventually enable researchers to predict a person's chances of hair loss.

Male baldness - also referred to as androgenetic alopecia or male pattern baldness (MPB) - affects a significant number of people in the United States, as the condition accounts for over 95 percent of all hair loss in men.

According to the American Hair Loss Association, two thirds of U.S. adults will be affected by MPB to a certain degree by the age of 35, and around 85 percent of men will have experienced significant hair loss by the age of 50.

A lot of these men are seriously affected by the condition, which can have a negative effect on a person's self-image, as well as on their interpersonal relationships.

Additionally, some genetic studies have even associated MPB with negative clinical outcomes such as prostate cancer and cardiovascular disease.

A new study - led by Saskia Hagenaars and David Hill of the University of Edinburgh in the United Kingdom - explores the genetic basis for the condition. The findings were published in the journal PLOS Genetics.

Scientists analyzed the genomic and health data of more than 52,000 men enrolled in the UK Biobank - an international health resource offering health information on more than 500,000 individuals.

The team located more than 250 independent genetic regions linked to severe hair loss.

The researchers split the 52,000 participants into two groups: a so-called discovery sample of 40,000 people and a target sample of 12,000 individuals. Based on the genetic variants that separated those with no hair loss from those with severe hair loss, the team designed an algorithm aimed to predict who would develop MPB.

The algorithmic baldness predictor is based on a genetic score, and although accurate predictions are still a long way off, the results of this study might soon enable researchers to identify subgroups of the population that are particularly prone to hair loss.

In the present study, researchers found that 14 percent of the participants with a submedian genetic score had severe MPB, and 39 percent had no hair loss. By contrast, 58 percent of those scoring in the top 10 percent on the polygenic score had moderate to severe MPB.

Co-lead author Saskia Hagenaars - a Ph.D. student at the University of Edinburgh's Centre for Cognitive Aging and Cognitive Epidemiology - comments on the findings:

"We identified hundreds of new genetic signals," Hagenaars says. "It was interesting to find that many of the genetics signals for male pattern baldness came from the X chromosome, which men inherit from their mothers."

The study's other lead author, Dr. David Hill, notes that the study did not collect data on the age of baldness onset, but only on hair loss pattern. However, he adds that, "we would expect to see an even stronger genetic signal if we were able to identify those with early-onset hair loss."

To the authors' knowledge, this is the largest genetic study of MPB to date.

The study's principal investigator, Dr. Riccardo Marioni, from the University of Edinburgh's Centre for Genomic and Experimental Medicine, explains the significance of the findings:

"We are still a long way from making an accurate prediction for an individual's hair loss pattern. However, these results take us one step closer. The findings pave the way for an improved understanding of the genetic causes of hair loss."

Learn how a drug promises robust new hair growth.

More here:

Genetic basis for male baldness identified in large-scale study - Medical News Today

Personalized medicine may do more to treat rather than prevent chronic diseases – NewsOK.com

Sharon Horesh Bergquist, Associated Press Published: February 15, 2017 9:20 PM CDT

Sharon Horesh Bergquist, Emory University

(THE CONVERSATION) Personalized medicine, which involves tailoring health care to each persons unique genetic makeup, has the potential to transform how we diagnose, prevent and treat disease. After all, no two people are alike. Mapping a persons unique susceptibility to disease and targeting the right treatment has deservedly been welcomed as a new power to heal.

The human genome, a complete set of human DNA, was identified and mapped a decade ago. But genomic science remains in its infancy. According to Francis Collins, the director of the National Institutes of Health, It is fair to say that the Human Genome Project has not yet directly affected the health care of most individuals.

Its not that there havent been tremendous breakthroughs. Its just that the gap between science and its ability to benefit most patients remains wide. This is mainly because we dont yet fully understand the complex pathways involved in common chronic diseases.

I am part of a research team that has taken on the ambitious goal of narrowing this gap. New technologies are allowing us to probe DNA, RNA, proteins and gut bacteria in a way that will change our understanding of health and disease. Our hope is to discover novel biological markers that can be used to diagnose and treat common chronic conditions, including Alzheimers disease, heart disease, diabetes and cancer.

But when it comes to preventing the leading causes of death which include chronic diseases, genomics and precision medicine may not do as much as we hope.

Chronic diseases are only partially heritable. This means that the genes you inherit from your parents arent entirely responsible for your risk of getting most chronic diseases.

The estimated heritability of heart disease is about 50 percent. Its 64 percent for Type 2 diabetes mellitus, and 58 percent for Alzheimers disease. Our environment and lifestyle choice are also major factors; they can change or influence how the information coded in our genes is translated.

Chronic diseases are also complex. Rather than being controlled by a few genes that are easy to find, they are weakly influenced by hundreds if not thousands of genes, the majority of which still elude scientists. Unlocking the infinite combinations in which these genes interact with each other and with the environment is a daunting task that will take decades, if ever, to achieve.

While unraveling the genomic complexity of chronic disease is important, it shouldnt detract from existing simple solutions. Many of our deadliest chronic diseases are preventable. For instance, among U.S. adults, more than 90 percent of Type 2 diabetes, 80 percent of coronary arterial disease, 70 percent of stroke and 70 percent of colon cancer are potentially avoidable.

Smoking, weight gain, lack of exercise, poor diet and alcohol consumption are all risk factors for these conditions. Based on their profound impact on gene expression, or how instructions within a gene are manifested, addressing these factors will likely remain fundamental in preventing these illnesses.

A major premise behind personalized medicine is that empowering patients and doctors with more knowledge will lead to better decision-making. With some major advances, this has indeed been the case. For instance, variants in genes that control an enzyme that metabolizes drugs can identify individuals who metabolize some drugs too rapidly (not giving them a chance to work), or too slowly (leading to toxicity). This can lead to changes in medication dosing.

When applied to prevention, however, identifying our susceptibility at an earlier stage has not aided in avoiding chronic diseases. Research challenges the assumption that we will use genetic markers to change our behavior. More knowledge may nudge intent, but that doesnt translate to motivating changes to our lifestyle.

A recent review found that even when people knew their personal genetic risk of disease, they were no more likely to quit smoking, change their diet or exercise. Expectations that communicating DNA-based risk estimates changes behavior is not supported by existing evidence, the authors conclude.

Increased knowledge may even have the unintended consequence of shifting the focus to personal responsibility while detracting from our joint responsibility for improving public health. Reducing the prevalence of chronic diseases will require changing the political, social and economic environment within which we make choices as well as individual effort.

Perhaps the most awaited hope of the genomic era is that we will be able to develop targeted treatments based on detailed molecular profiling. The implication is that we will be able to subdivide disease into new classifications. Rather than viewing Type 2 diabetes as one disease, for example, we may discover many unique subtypes of diabetes.

This already is happening with some cancers. Patients with melanoma, leukemia or metastatic lung, breast or brain cancers can, in some cases, be offered a molecular diagnosis to tailor their treatment and improve their chance of survival.

We have been able to make progress in cancer therapy and drug safety and efficacy because specific gene mutations control a persons response to these treatments. But for complex, chronic diseases, relatively few personalized targeted treatments exist.

Customizing treatments based on our uniqueness will be a breakthrough, but it also poses a challenge: Without the ability to test targeted treatments on large populations, it will make it infinitely harder to discover and predict their response.

The very reason we group people with the same signs and symptoms into diagnoses is to help predict the average response to treatment. There may be a time when we have one-person trials that custom tailor treatment. However, the anticipation is that the timeline to getting to such trials will be long, the failure rate high and the cost exorbitant.

Research that takes genetic risk of diabetes into account has found greater benefit in targeting prevention efforts to all people with obesity rather than targeting efforts based on genetic risk.

We also have to consider decades of research on chronic diseases that suggest there are inherent limitations to preventing the global prevalence of these diseases with genomic solutions. For most of us, personalized medicine will likely complement rather than replace one-size-fits-all medicine.

Where does that leave us? Despite the inherent limitations to the ability of genomic medicine to transform health care, medicine in the future should unquestionably aspire to be personal. Genomics and molecular biosciences will need to be used holistically in the context of a persons health, beliefs and attitudes to fulfill their power to greatly enhance medicine.

This article was originally published on The Conversation. Read the original article here: http://theconversation.com/personalized-medicine-may-do-more-to-treat-rather-than-prevent-chronic-diseases-71474.

See more here:

Personalized medicine may do more to treat rather than prevent chronic diseases - NewsOK.com

AP, HHMI collaborate on expanded science, health coverage – New Jersey Herald

Posted: Feb. 15, 2017 8:00 am Updated: Feb. 15, 2017 3:09 pm

NEW YORK (AP) The Associated Press is teaming up with the Howard Hughes Medical Institute's Department of Science Education to expand its coverage of science, medicine and health journalism.

The initial collaboration includes two pilot projects. With the first project, AP will create and distribute a series of stories, profiles, videos and graphics focusing on genetic medicine. The second project will look at a variety of science topics in the news that will help readers stay current on the latest science research and make informed decisions on topics ranging from the environment, to public health.

"This collaboration brings wider attention and new storytelling tools to evidence-based, factual science," AP Executive Editor Sally Buzbee said.

HHMI, based in Chevy Chase, Maryland, supports the advancement of biomedical research and science education. The organization's origin dates back to the late 1940s when a small group of physicians and scientists advised Hughes. The medical institute was created in 1953.

The primary purpose of the organization is to promote human knowledge in the field of the basic sciences and its effective application for the benefit of mankind, according to its charter. In fiscal 2016, it provided $663 million in U.S. biomedical research and $86 million in grants and other support for science education.

HHMI's Department of Science Education, the largest private, nonprofit supporter of science education in the country, will provide funding for the AP projects. The funding will allow AP to increase the amount of science-related stories it provides to news organizations and add more journalists to support its current science reporting team. HHMI will also offer expert background information and educational material.

While the AP will receive funding and utilize HHMI's expertise when crafting its content, it maintains full editorial control of published material.

"We're proud to stand shoulder to shoulder with the world's most respected news organization to ensure that the best evidence around important scientific topics is presented clearly and distributed widely," said Sean B. Carroll, vice president of HHMI's Department of Science Education.

See the article here:

AP, HHMI collaborate on expanded science, health coverage - New Jersey Herald

Scientists Want to Genetically Engineer Humans – National Review

I first became involved deeply in the debates over biotechnology during the great embryonic stem cell debate.

During that time, I watched in stunned and appalled amazement as scientists lied to legislators and hyped the imminent likelihood of CURES! CURES! CURES! in order to win a political debate and gain federal research grants.

During that experience, Iconcluded that many in the sector essentially have an arrogant we decide what should and should not be done in science ethicrather thansociety as a whole determining proper parameters through democratic processesand moreover, that somehave an essentially anything goes mentality at odds with the views of the rest of society.

More, these advocatespretend to be willing to accept reasonable limitations. But a close look reveals these restraints are primarily over things they cannot yet do.

Then, aftera controversial technology becomes doable, the once unthinkable is suddenly moved into the full speed ahead! file.

Now, that pattern holds with human genetic engineering. From the New York Times story:

An influential science advisory group formed by the National Academy of Sciences and the National Academy of Medicine on Tuesday lent its support to a once unthinkable proposition: the modification of human embryos to create genetic traits that can be passed down to future generations.

This type of human gene editing has long been seen as an ethical minefield. Researchers fear that the techniques used to prevent genetic diseases might also be used to enhance intelligence, for example, or to create people physically suited to particular tasks, like serving as soldiers

Just over a year ago, an international group of scientists said it would be irresponsible to proceed with making heritable changes to the human genome until risks could be better assessed and there was broad societal consensus about the appropriateness of any proposed change. No one is pretending that such a consensus now exists.

But in the year that the committee was deliberating, [bioethicist] Ms. [Alta] Charo said, the techniques required to perform this sort of gene editing have passed crucial milestones.

See what I mean?

Know this: It starts with health and that justification is deployed to sway the public and regulators.

But soon, these technologies move to promoting enhancement and eugenic designalready seen in currently deployed reproductive technologies.

Continue reading here:

Scientists Want to Genetically Engineer Humans - National Review

Genetically Engineered Mice DGAF About Cocaine – Inverse

Researchers have been creating drug-addicted laboratory mice for years, but now, theyve created one capable of just saying no. Armed with extra-strong synapses created through genetic engineering, the new mice were able to resist addiction, even when presented with an ODs worth of cocaine. The freak mice were discovered by accident: The genetic engineering strategy that produced them was originally thought to make them more prone to addiction.

The University of British Columbia (UBC) researchers, publishing their work in a new Nature Neuroscience article today, custom-designed mice that produced higher-than-usual levels of the protein cadherin, which strengthened their brains synapses, the gaps between neurons that brain signals jump over. They originally thought that strengthening the reward-associated parts of the brain with cadherin would make the mice more addiction prone, but when the cadherin-strengthened mice were injected with enough cocaine to become addicted and then given the option to seek out some more coke or not, they were only half as interested in the substance as their unaltered counterparts.

A close examination of this counterintuitive result revealed that cadherin inhibits a particular neurochemical receptor in the mices brains, making it harder not easier for some neurons to signal each other. With cadherin interfering with their brains signals, the mice dont anticipate the pleasure derived from cocaine and, in turn, their behavior is not affected. In short, the mice seem to be addiction-proof.

The strength of our synapses is, among other factors, what helps us learn new tasks and make new associations, but the engineered mice appeared to have formed no strong associations about cocaine, despite being injected repeatedly. The experiments results reinforce previous theories that cadherin plays a vital role in addiction and behavioral change, though the exact nature of that role still isnt clear.

Shernaz Bamji, Ph.D., a professor in the Department of Cellular and Physiological Sciences and one of the papers authors, explained to Inverse that these results mean it could some day be possible to treat addiction by changing the way learning occurs in certain areas of the brain itself, whether through cadherin, or using some other chemical. The more we learn about which functions within the brain we should be focusing on, she says, the closer we come to being able to predict who will be the most vulnerable to addiction. The results, however, do not mean doctors can start fortifying addiction-prone humans with cadherin the way Bamji and her colleagues did with the mice theres a lot we still have to understand about the neurochemistry of learning before we do that.

For normal learning, we need to be able to both weaken and strengthen synapses, Bamji said in a statement. That plasticity allows for the pruning of some neural pathways and the formation of others, enabling the brain to adapt and to learn. Ideally, we would need to find a molecule that blocks formation of a memory of a drug-induced high, while not interfering with the ability to remember important things.

The study adds to a growing body of evidence against the idea that addiction is all about an individuals lack of willpower. Such arguments are usually lazy substitutions for the actual science, which says that addiction to substances like cocaine has a lot to do with our genes. Some people have genetic mutations that leave their synapses more vulnerable to addictive substances. Fortunately, geneticists are now one step closer to figuring out how to strengthen those synapses before theyre attacked.

Photos via University of British Columbia, Science News / V. Kumar and K. Kim

See the original post here:

Genetically Engineered Mice DGAF About Cocaine - Inverse

uniQure details three-pronged gene therapy trial program – FierceBiotech

uniQure plots to initiate a three-pronged clinical trial program next year as key assets from its in-house pipeline and Bristol-Myers Squibb collaboration advance. uniQure aims to move its hemophilia B gene therapy, AMT-060, into a pivotal trial while working to advance a Huntington's disease asset and Bristol-Myers-partnered heart failure candidate into the clinic.

Matthew Kapusta, who took over as CEO of uniQure in September, detailed the strategy in a talk(registration required)at Leerinks healthcare conference. The plan will follow the strategy uniQure set out in November when it laid off workers and stepped down its interest in Sanfilippo B and Parkinsons disease to prioritize investment in the aforementioned three programs.

The closely watched hemophilia B remains the centerpiece of the company. While investors weredisappointed by the Factor IX activity presented in a succession of readoutsespecially when compared to data from Spark Therapeutics rival gene therapyuniQure maintainedAMT-060 has a compelling efficacy and safety profile.

Kapusta claimed patients, physicians and the FDA share uniQures focus on reductions in FIX transfusions and rates of spontaneous bleeding rather than FIX activity.

In the interaction that we had with the FDA, it was very clear that they were looking at defined clinical benefits. And I think they were defining clinical benefit not in terms of Factor IX activity but in terms of impact on annualized bleeding rate, he said.

uniQure will have another chance to hear the FDAs views at its end of phase 2 meeting set to take place before the end of the quarter. The meeting will mark the start of a process intended to lead uniQure into a pivotal trial next year.

The start of phase 3 should contribute to a busy year in the clinic for uniQure. Following a year ofcollaboration with Bristol-Myers working on manufacturing matters, uniQure is now in the middle of animal studies that could set it up to file an INDand possibly start a trialnext year. uniQure isrunning a dose expression study of the heart failure gene therapy in healthy and diseased pigs.

In parallel, uniQure is working to get its Huntington's disease asset into the clinic. The candidate,the result of a five-year project, uses the AAV5 vector to deliver a microRNA intended to silence the Huntington gene. In mice, administration of the gene therapy into the striatum led to a 50% knockdown in the cortex.

Continued here:

uniQure details three-pronged gene therapy trial program - FierceBiotech

In a possible step forward for gene therapy, Stanford researchers made mice glow like fireflies – Stanford University News

Timothy Blake, a postdoctoral fellow in the Waymouth lab, was hard at work on a fantastical interdisciplinary experiment. He and his fellow researchers were refining compounds that would carry instructions for assembling the protein that makes fireflies light up and deliver them into the cells of an anesthetized mouse. If their technique worked, the mouse would glow in the dark.

Colin McKinlay and Jessica Vargas are co-lead authors of research that could mark a significant step forward for gene therapy by providing a new way of inserting therapeutic proteins into diseased cells. (Image credit: L.A. Cicero)

Not only did the mouse glow, but it also later woke up and ran around, completely unaware of the complex series of events that had just taken place within its body. Blake said it was the most exciting day of his life.

This success, the topic of a recent paper in Proceedings of the National Academy of Sciences, could mark a significant step forward for gene therapy. Its hard enough getting these protein instructions, called messenger RNA (mRNA), physically into a cell. Its another hurdle altogether for the cell to actually use them to make a protein. If the technique works in people, it could provide a new way of inserting therapeutic proteins into diseased cells.

Its almost a childlike enthusiasm we have for this, said chemistry Professor Robert Waymouth, co-senior author of the study. The code for an insect protein is put into an animal and that protein is not only synthesized in the cells but its folded and it becomes fully functional, capable of emitting light.

Although the results are impressive, this technique is remarkably simple and fast. And unlike traditional gene therapy that permanently alters the genetic makeup of the cell, mRNA is short-lived and its effects are temporary. The transient nature of mRNA transmission opens up special opportunities, such as using these compounds for vaccination or cancer immunotherapy.

Gene therapy is a decades-old field of research that usually focuses on modifying DNA, the fundamental genetic code. That modified DNA then produces a modified mRNA, which directs the creation of a modified protein. The current work skips the DNA and instead just delivers the proteins instructions.

Previous work has been successful at delivering a different form of RNA called short interfering RNA, or siRNA but sending mRNA through a cell membrane is a much bigger problem. While both siRNA and mRNA have many negative charges so-called polyanions mRNA is considerably more negatively charged, and therefore more difficult to sneak through the positively charged cell membrane.

What the researchers needed was a positively charged delivery method a polycation to complex, protect and shuttle the polyanions. However, this alone would only assure that the mRNA made it through the cell membrane. Once inside, the mRNA needed to detach from the transporter compound in order to make proteins.

The researchers addressed this twofold challenge with a novel, deceptively straightforward creation, which they call charge-altering releasable transporters (CARTs).

What distinguishes this polycation approach from the others, which often fail, is the others dont change from polycations to anything else, said chemistry Professor Paul Wender, co-senior author of the study. Whereas, the ones that were working with will change from polycations to neutral small molecules. That mechanism is really unprecedented.

As part of their change from polycations to polyneutrals, CARTs biodegrade and are eventually excreted from the body.

This research was made possible through coordination between the chemists and experts in imaging molecules in live animals, who rarely work together directly. With this partnership, the synthesis, characterization and testing of compounds could take as little as a week.

We are so fortunate to engage in this kind of collaborative project between chemistry and our clinical colleagues. It allowed us to see our compounds go from very basic building blocks all the way from chemicals we buy in a bottle to putting a firefly gene into a mouse, said Colin McKinlay, a graduate student in the Wender lab and co-lead author of the study.

Not only did this enhanced ability to test and re-test new molecules lead to the discovery of their charge-altering behavior, it allowed for quick optimization of their properties and applications. As different challenges arise in the future, the researchers believe they will be able to respond with the same rapid flexibility.

After showing that the CARTs could deliver a glowing jellyfish protein to cells in a lab dish, the group wanted to find out if they worked in living mice, which was made possible through the expertise of the Contag lab, run by Christopher Contag, professor of pediatrics and of microbiology and immunology and co-senior author of the study. Together, the multidisciplinary team showed that the CARTs could effectively deliver mRNA that produced glowing proteins in the thigh muscle or in the spleen and liver, depending on where the injection was made.

The researchers said CARTs could move the field of gene therapy forward dramatically in several directions.

Gene therapy has been held up as a silver bullet because the idea that you could pick any gene you want is so alluring, said Jessica Vargas, co-lead author of the study, who was a PhD student in the Wender lab during this research. With mRNA, there are more limitations because the protein expression is transient, but that opens up other applications where you wouldnt use other types of gene therapy.

One especially appropriate application of this technology is vaccination. At present, vaccines require introducing part of a virus or an inactive virus into the body in order to elicit an immune response. CARTs could potentially cut out the middleman, directly instructing the body to produce its own antigens. Once the CART dissolves, the immunity remains without any leftover foreign material present.

The team is also working on applying their technique to another genetic messenger that would produce permanent effects, making it a complementary option to the temporary mRNA therapies. With the progress already made using mRNA and the potential of their ongoing research, they and others could be closer than ever to making individualized therapeutics using a persons own cells. Creating a firefly protein in a mouse is amazing but, more than that, this research is part of a new era in medicine, said Wender.

Additional co-authors of this study, Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals, include Timothy Blake, Jonathan Hardy, Masamitsu Kanada and Christopher Contag. Waymouth is also a professor, by courtesy, of chemical engineering, a member of Stanford Bio-X, a faculty fellow of Stanford ChEM-H and an affiliate of the Stanford Woods Institute for the Environment. Wender is also a professor, by courtesy, of chemical and systems biology, a member of Stanford Bio-X, a member of the Stanford Cancer Institute and a faculty fellow of Stanford ChEM-H. Contag is also a professor, by courtesy, of radiology and of bioengineering, a member of Stanford Bio-X, a member of the Child Health Research Institute and a member of the Stanford Cancer Institute.

This work was funded by the Department of Energy, the National Science Foundation, the National Institutes of Health, the Chambers Family Foundation for Excellence in Pediatric Research, the Child Health Research Institute, the Stanford Center for Molecular Analysis and Design and the National Center for Research Resources.

The rest is here:

In a possible step forward for gene therapy, Stanford researchers made mice glow like fireflies - Stanford University News

Lonza to Manufacture Selecta Gene Therapy Candidate for MMA – Genetic Engineering & Biotechnology News

Lonzas viral-based therapeutics unit Lonza Houston has agreed to manufacture an Anc80-AAVbased gene therapy product for Selecta Biosciences proprietary program for the treatment of methylmalonic acidemia (MMA) and may produce other Anc80-based products for which Selecta holds exclusive options, the companies said today.

The companies said their strategic manufacturing agreementwhose value was not disclosedwill apply to Selectas program Lonzas expertise in developing robust and industry-scale manufacturing platforms for viral-based products.

Lonza will utilize our extensive cGMP manufacturing knowledge and world-class quality systems to help Selecta Biosciences develop promising novel therapeutics for patients impacted by MMA and other devastating diseases, Andreas Weiler, Ph.D., head of the Emerging Technologies Business Unit for Lonzas Pharma & Biotech segment, said in a statement.

Anc80-AAV, an in silico-designed synthetic gene therapy vector, has generated preclinical data suggesting its potential to provide what the companies termed superior gene expression levels in the retina, liver, muscle, cochleas outer hair cells, and other tissue targets. Anc80-AAV has also shown reduced cross-reactivity compared to naturally occurring adeno-associated viral vectors (AAVs) now in clinical development, Lonza and Selecta said.

Selecta exclusively licensed Anc80 for MMA from Massachusetts Eye and Ear (MEE) in May 2016. The vector was developed by the laboratory of Luk H. Vandenberghe, Ph.D., director of MEEs Grousbeck Gene Therapy Center and an assistant professor at Harvard Medical School. Under the license agreement, whose value was not disclosed, Selecta also has the exclusive option to develop gene therapies using Anc80 for additional predefined lysosomal storage, genetic muscular, and genetic metabolic diseases.

Selecta focuses on combining novel and proprietary viral vectors with its immune tolerance Synthetic Vaccine Particles (SVP) to enable the first nonimmunogenic gene therapies, providing the potential for repeat dosing.

Selecta said it intends to combine Anc80 with recently discovered transgenes and Selectas SVP-Rapamycin to create a novel gene therapy candidate for MMA. The candidate will be designed to enable treatment of patients with and without pre-existing anti-AAV antibodies, prevent cellular immune responses that often reduce the expression levels of gene therapies, and provide the ability to administer repeat gene therapy doses to achieve sufficient levels of methylmalonyl-CoA mutase, the enzyme that MMA patients lack.

To advance the MMA program, Selecta last year entered into a Collaborative Research and Development Agreement (CRADA) with MEE and the NIHs National Human Genome Research Institute. The CRADAs principal investigators are Dr. Vandenberghe and Charles Venditti, M.D., Ph.D., senior investigator and head, Organic Acid Research Section, Medical Genomics and Metabolic Genetics Branch.

More here:

Lonza to Manufacture Selecta Gene Therapy Candidate for MMA - Genetic Engineering & Biotechnology News

Rare Muscle Disease Treated Successfully with Gene Therapy – Genetic Engineering & Biotechnology News

Work on gene therapy is showing significant progress for restoring muscle strength and prolonging lives in dogs with a previously incurable, inherited neuromuscular disease, according to scientists at the University of Washington (UW) Medicine Institute for Stem Cell and Regenerative Medicine.

The disease arises from a mutation in genes that normally make myotubularin, a protein essential for proper muscle function. Puppies with this naturally occurring mutation exhibit several features of babies with the same defective gene. The rare disorder, called X-linked myotubular myopathy, or XLMTM, affects only males. It causes fatal muscle wasting. Both dogs and boys with the disease typically succumb in early life due to breathing difficulties.

For decades, researchers have struggled to find suitable treatments for genetic muscle diseases like this one. Collaborating research groups in the United States and France found a way to safely replace the disease-causing MTM gene with a healthy gene throughout the entire musculature of affected dogs.

Their most recent findings ("Systemic AAV8-Mediated Gene Therapy Drives Whole-Body Correction of Myotubular Myopathy in Dogs") werepublished online inMolecular Therapy.The paper reports that diseased dogs treated with a single infusion of the corrective therapy were indistinguishable from normal animals 1 year later.

"This regenerative technology allowed dogs that otherwise would have perished to complete restoration of normal health," said Martin K. "Casey" Childers, Ph.D., UW medicine researcher and physician. Dr. Childers is a professor of rehabilitation medicine at the University of Washington School of Medicine and co-director of the Institute for Stem Cell and Regenerative Medicine.

Gene therapy holds the promise to treat many inherited diseases. To date, this approach has not been widely translated into treatment of skeletal muscle disorders.

"We report here a gene therapy dose-finding study in a large animal model of a severe muscle disease where a single treatment resulted in dramatic rescue," said Dr. Childers. The findings demonstrate potential application across a wide range of diseases and broadly translate to human studies. The data supports the development of gene therapy clinical trials for myotubular myopathy, the researchers concluded.

The study was conducted in collaboration with Harvard University, Medical College of Wisconsin, Virginia Tech, INSERM, and Genethon.

Read more from the original source:

Rare Muscle Disease Treated Successfully with Gene Therapy - Genetic Engineering & Biotechnology News

Gene Therapy Technologies, Markets and Companies 2017 … – Business Wire (press release)

DUBLIN--(BUSINESS WIRE)--Research and Markets has announced the addition of Jain PharmaBiotech's new report "Gene Therapy - Technologies, Markets and Companies" to their offering.

Gene therapy technologies are described in detail including viral vectors, nonviral vectors and cell therapy with genetically modified vectors. Gene therapy is an excellent method of drug delivery and various routes of administration as well as targeted gene therapy are described. There is an introduction to technologies for gene suppression as well as molecular diagnostics to detect and monitor gene expression.

Clinical applications of gene therapy are extensive and cover most systems and their disorders. Full chapters are devoted to genetic syndromes, cancer, cardiovascular diseases, neurological disorders and viral infections with emphasis on AIDS. Applications of gene therapy in veterinary medicine, particularly for treating cats and dogs, are included.

Research and development is in progress in both the academic and the industrial sectors. The National Institutes of Health (NIH) of the US is playing an important part. As of 2015, over 2050 clinical trials have been completed, are ongoing or have been approved worldwide. A breakdown of these trials is shown according to the geographical areas and applications.

The markets for gene therapy are difficult to estimate as there is only one approved gene therapy product and it is marketed in China since 2004. Gene therapy markets are estimated for the years 2016-2026. The estimates are based on epidemiology of diseases to be treated with gene therapy, the portion of those who will be eligible for these treatments, competing technologies and the technical developments anticipated in the next decades. In spite of some setbacks, the future for gene therapy is bright. The markets for DNA vaccines are calculated separately as only genetically modified vaccines and those using viral vectors are included in the gene therapy markets

Profiles of 188 companies involved in developing gene therapy are presented along with 233 collaborations. There were only 44 companies involved in this area in 1995. In spite of some failures and mergers, the number of companies has increased more than 4-fold within a decade. These companies have been followed up since they were the topic of a book on gene therapy companies by the author of this report.

Key Topics Covered:

Part I: Technologies & Markets

1. Introduction

2. Gene Therapy Technologies

3. Clinical Applications of Gene Therapy

4. Gene Therapy of Genetic Disorders

5. Gene Therapy of Cancer

6. Gene Therapy of Neurological Disorders

7. Gene Therapy of Cardiovascular Disorders

8. Gene therapy of viral infections

9. Research, Development and Future of Gene Therapy

10. Regulatory, Safety and Ethical Issues of Gene Therapy

11. Markets for Gene Therapy

12. References

Part II: Companies

13. Companies involved in Gene Therapy

For more information about this report visit http://www.researchandmarkets.com/research/npn4n6/gene_therapy

Read the original post:

Gene Therapy Technologies, Markets and Companies 2017 ... - Business Wire (press release)

Will Artificial Intelligence Take Our Jobs? We Asked A Futurist – Huffington Post Australia

In 'Back To The Future', Marty and Doc travel in time from 1985 to 2015. In the fictional version of 2015 there's hoverboards and self-lacing shoes. While the latter happened IRL in late 2016, a lot of the film's other future predictions were a little off.

Though what's not too far fetched is the idea of robots, or artificial intelligence, working its way into our very real and ordinary lives in the not too distant future. Self-driving cars are already a thing, and that's only the beginning.

"Artificial Intelligence (or AI) is likely to do to white collar jobs like how machines have been doing blue collar work. In other words, just like our brawns have been digitised, so will our brains be," Anders Sorman-Nilsson, global futurist and TEDx speaker told The Huffington Post Australia.

Sorman-Nilsson is the author of Seamless: The Futurephile's Guide To Leading Digital Adaptation And Human Transformation. His book explores how life and business will change in the future and what can be done now to best adapt to that. A futurephile refers to someone who is open and excited about technology in the future, while a futurephobe is someone who is frightened of it.

"What we should more concerned about is not necessarily the exponential change in artificial intelligence or robotics, but about the stagnant response in human intelligence. For example, schools and universities are now preparing students for jobs that will no longer be in existence 10 years from now.

"On the flip side, adaptive, agile and creative humans will figure out how to partner with the machines and new forms of intelligence. For example, we can imagine a near future where Siri stops behaving emotionally unintelligently and instead fully replaces your executive assistant, marketing manager, and sales support," Sorman-Nilsson said.

Sorman-Nilsson says that while artificial intelligence will run the back office of your business, it is unlikely to be the front of your brand.

"Neo-luddites [those who are considered to be anti-technology] who prefer apathy, complacency or nostalgia will try to fight this next evolution of digital disruption, and will likely be left behind. Anything that can be digitised will eventually be digitised, so a key question for anyone seeking to scenario plan their future career to ensure their thinking remains attractive in 2027 is: what thinking skills can never be digitised?"

"Fundamentally human skills like entrepreneurship, strategic thinking, philosophy, team-building, creativity, empathy, emotionally intelligent leadership, counter-intuitive insights, and connected sales(wo)manship will have a premium placed upon them. In other words, less time pushing paper and doing menial stuff, and more time doing meaningful stuff," Sorman-Nilsson said.

"We do a lot of scenario planning with banks, which in many ways are really just technology companies with banking licenses. So, yes, in a cashless, paperless and seamless banking future, a lot of banking jobs will be lost to automation and artificial intelligence," Sorman-Nilsson said.

"What our simulations show is that one aspect to the debate around artificial intelligence that is frequently lost is the fact that AI and digitisation will impact certain activities in our everyday lives, such as marketing automation or robotic advice, but it may not fully remove the 50 percent of jobs that some pundits talk about. In the face of this, as humans we need to be a little paranoid about the exponential changes ahead -- enough so to move us into upgrading our thinking -- but not so much as to be paralysed."

Probing Sorman-Nilsson on if us laypeople should be afraid of this future, he says it all comes down to how we think.

"I see a correlation between what I term 'futurephobes' in my most recent book, who tend to posses a general technophobia which includes deep suspicion of artificial intelligence, and dystopic views of that same future. Disruption is a signal from the future that it is high time to adapt, and that smart investments in the right hardware and software, which includes your own thinking software, have to be made."

"To me it is astounding that in Australia we are so obsessed with bricks and mortar property, but we are less concerned with investments in our own intellectual property, and AI certainly raises the stakes to ensure our thinking remains future-compatible. If you think like a 'futurephile' you will see that AI will free up our time to do meaningful work -- a sales professional, rather than spending 30 to 40 percent of their day doing data-entry, can fit in more meaningful meetings with humans, and a financial adviser can focus on more actively helping their clients' fulfil their financial dreams by outsourcing some regulatory work to RegTech instead," Sorman-Nilsson said.

"While my mum, who is my toughest pro-bono client, tends to think of the future as digitally dehumanised, for a futurephile like myself, the future holds the promise of an even more human era," Sorman-Nilsson said.

"A future where we can connect more deeply with our loved ones because we are no longer punching spreadsheets. One where our artificially intelligent assistant locks in the most optimal price and payment terms for our family holidays based on our unique psychographics, budgets and interests while we sleep, and where we are freed up to meditate or rejoin the local football club because we are delivered from the stress of pointless paperwork and meaningless visits to the post office to prove our identities."

Sorman-Nilsson says that artificial intelligence will excel in the fields of big data -- like diagnosis, investment advice, personalised medicine, smart buildings, energy management, transport, logistics, engineering and accounting.

"This will mean that your 'left brain' might get some much needed support, while your 'right brain' will be able to flourish. But while the promise of AI is exciting, it will take a really good human sales(wo)man to make us really trust and buy into artificial intelligence."

In his role as a futurist, Sorman-Nilsson is looking forward to what's to come.

"As a global futurist and futurephile, one of the things that excites me about artificial intelligence is the death of procrastination -- anything 'left brained' that we avoided and delayed doing, like taxes, filing, travel expense coding, receipt management, and updating our calendars will be procrastinated on no longer. That in and of itself should sell you on the virtue of AI -- unless you of course derive a lot of pleasure from these activities, in which case I urge you to upgrade and diversify your thinking," Sorman-Nilsson said.

ALSO ON HUFFPOST AUSTRALIA

Visit HuffPost Australia's profile on Pinterest.

Will Artificial Intelligence Take Our Jobs? We Asked A Futurist

Read the rest here:

Will Artificial Intelligence Take Our Jobs? We Asked A Futurist - Huffington Post Australia

Fashwave: the far-right phenomenon with Futurist forefathers – The Student

In darker corners of the internet there are growing communities of alt-right meme-machines mocking liberals and advocating white supremacy. However, recently another facet of the movement has emerged: fashwave, the musical genre where 80s electronica meets fascism.

Fashwave is essentially a subgenre of vapourwave, a creation of the early 2010s characterised by its slowed-down, lo-fi 80s A E S T H E T I C accompanied by images inspired by early computing technology and TV advertisements, simultaneously rebuking and embracing capitalist alienation. Its proximity to the latter is that at first listen you might not even realise you were hearing the product of a white nationalist (although titles such as Right Wing Death Squads and Team White do tend to give it away).

Fashwave effectively encapsulates a particular aspect of the Zeitgeist. With the roaring success of nostalgia-drenchedStranger Things last year, and the rapid rise of the political right, it is perhaps not so bizarre that the two would join forces to form the hybrid phenomenon. Indeed, one supporter declared on Twitter that what binds white nationalists together is a belief in the supremacy of the 1980s. It seems that the decade holds a special place in the hearts of alt-right members, who remember (or at least regard) it fondly as the last days of white America.

The genre is a very new one, born in the wake of the Paris terror attacks in November 2015. Leading fashwave artist Cybernazi said in an interview last year that his music was inspired by the horror the event instilled in him. This influence is evident genre-wide, with Xuriouss (another leading fashwave producer) oldest song entitled Requiem for Paris.

Leading alt-right figures have championed fashwave, describing it as the movements soundtrack. Of these the most well-known is probably Richard Spencer, the man who recently went viral for being punched in the face during the Washington DC street protests on the day of President Trumps inauguration in the middle of explaining his affinity with Pepe the Frog. The video has been repeatedly remixed online, meaning that you can now watch as Spencer is hit in time to the opening drum machine bars of New Orders Blue Monday.

Ironically, New Order is one of his favourite bands (alongside Depeche Mode) and is apparently a big influence of this new electronic genre. New Orders name has long attracted controversy and allegations of Nazi sympathies, all of which have been dismissed by its members. However, in an interview with VICEs music channel THUMP, Spencer said he thought the 80s legends were consciously or unconsciously channelling [] something darker, more serious, maybe more authoritarian.

This adoption of popular culture by fascists is nothing new. It is not even the first time this kind of music has been used the Swedish far right hijacked this particular vein of 1980s synth-pop when it was contemporary. However, this is the first time support has been so seemingly concentrated on one genre. Historically punk and other musical movements have attracted a fascist following, but far right supporters in the 21st century say that these forms are dead, and that self-produced electronic music as the artistic expression of the millennial generation is the natural fit.

Modern day far-right producers still acknowledge their historical influences however. Cybernazi described fashwave as the direct heir of Futurism, and it is not difficult to see why. Futurism was an artistic movement which came out of Italy in the early 20th century, in the days of Mussolini. The genre was inspired by the great technological advances happening at that time and the violence of war.

Nowadays, instead of trains and automobiles, fascist musicians are inspired by the creative possibilities of big data and the infinite virtual world of the internets capacity to bring people together. As with the alt-right movement as a whole it is easy to get caught up in the sensation and lose sight of the true scale of fashwaves popularity. Although the concept of fashwave is attention-grabbing, its listeners can really only be found in a very select niche of the internet. Even its most popular songs have only around 50 thousand views on YouTube. The movement is undoubtedly growing; there is no denying that. But all things considered you are unlikely to stumble across it in the soundtrack to the next Stranger Things instalment any time soon.

Image: Terri Po

Here is the original post:

Fashwave: the far-right phenomenon with Futurist forefathers - The Student

Elon Musk: Tesla Will Pay for Damages Caused by Hero Driver – Futurism

In Brief

In an amazing Autobahn maneuver on Monday, Tesla Model S driver Manfred Kick saved the life of 50-year-old man who lost consciousness behind the wheel. The unconscious driver was in a VW Passat station wagon, which the Tesla driver noticed was swerving on the busy road, according to the Munich fire services report.

After alerting the appropriate authorities, Kick slowed his car in front of the station wagon, allowing the Passat to crash into him from behind. He kept his foot on the brakes, forcing both vehicles to a controlled stop. Kicks courage and concern for a fellow driverearned him praise from the authorities and the media, as well as a congratulatory tweet from Tesla CEO and founder Elon Musk himself: Congrats to the Tesla owner who sacrificed damage to his own car to bring a car with an unconscious driver safely to a stop!

Now, it looks like the driver will be getting more than just accolades. Musk has said that Tesla will shoulder the cost of repairs for Kicks Model S. Police estimated the damages for the accident to total around 10,000 ($10,600 USD). Musk also said that Tesla will expedite the repairs for Kicks 70,000 ($74,686 USD) Model S, a surely welcome turn of events considering Teslas can take significant time to repair in certain markets. All proof that not all good deeds go unnoticed.

Read the original:

Elon Musk: Tesla Will Pay for Damages Caused by Hero Driver - Futurism

The World’s First Flying Taxis Will Take to the Skies in Five Months – Futurism

In Brief

Were a lot closer to flying cars that we think. In fact, Dubai has already begun testing a prototype of a self-driving hover-taxi with the hope of launching an aerial shuttle service by July.

The autonomous aerial vehicle exhibited at the World Government Summit is not just a model. We have already experimented (with) the vehicle in a flight in (the) Dubai sky. RTA will spare no effort to launch the AAV in July 2017, shares director general of the Roads and Transport Authority (RTA) Mattar Al-Tayer.

To avail of the taxi service, passengers will simply select a destination before they board the vehicle with the help of a ground control center. The EHang 184 quadcoptercan travel on a programmed course at 100 km an hour (60 mph) at an altitude of 300 meters (1,000 feet), the authority said in a statement.

The service is meant to help reduce traffic congestion along the Emirates main thoroughfares, and was built to withstand the countrys extreme temperatures during summer. With this new innovation, Dubai couldreach its goal of becoming a world leader in driverless technology by 2030.

See the article here:

The World's First Flying Taxis Will Take to the Skies in Five Months - Futurism

Futurist Shock – Chronicle of Higher Education (subscription) (blog)

Half a century ago, Alvin Toffler published a book about what happens to people when they are overwhelmed by change. Future Shock became a 1970 chart-topper.

Tofflers phrase future shock tells us something of the history of cultural anxiety. It also speaks to our response to change now in 2017, the very adolescence of the 21st century, when to be overwhelmed by change has become the standing condition of modernity.

Tofflers book begat an industry, lodged in no small part in eager business and tech programs, where it has become a commonplace to speak of futurists, meaning people who specialize in the study of our response to rapid change.

Reference books now encode futurist as one whose business is futuring. An aspect of futuring is visioning.

A 2015 article in The Atlantic asks why more women arent futurists, which would of course require them to be futuring, as well asvisioning a lot more than those who count such things imagine women are.

Some readers will call futuring and visioning examples of verbing, making verbs out of nouns, which sounds innocent enough. But I admit that when I hear futuring Im torn between imagining a breathless TED talk and a street-front fortune tellers window.

A century ago, this group of terms signified differently.Futurism or in Italian, futurismo is the early-20th-century art movement that celebrated speed, machines, and violence, sometimes in absurdist juxtapositions. Marinetti, a famous futurist, held forth on many subjects, including food. He hated pasta, for example, because he thought it slowed people down, and he envisioned a future without it.

With a rapidity that Marinetti might have admired, weve gone beyond futuring all the way to the verb form to future. Lets future it, Bob. To future in this instance seems to mean postpone.

Greg Britton at Johns Hopkins University Press, and one of my informants on such things, tells me hes also heard the verbal form parking lot, as in Yes, Ann, were going to parking lot that project. (Presumably in LA this would be Yes, Ann, were going to valet parking lot that project.)

What do early-20th-century Italian futurism and our up-to-the-minute analytic anxiety about futuring have in common? At least a triumphalist idea of smashing models and seeing more clearly.

Seeing clearly is, after all, what a clairvoyant is supposed to be able to do. Thats what the word means.

Im less concerned with policing the line between a) knowing which way the wind is blowing and b) having second sight. But futurists have had an awful lot of air time.

So what are our alternatives? No one yet dares identify as a pastist the word doesnt even look right but it would mean someone who analyzes things that have happened and uses that insight clair or not to help tackle the problems of the moment.

Oh wait, we do have a word for that profession. Its historian.

Most are too modest to call themselves futurists,but historians, whoknow how to think about complex things, are worth listening to now more than ever, when we need an understanding of history to help us sort out an enormous mess we just cant future.

If youre afuturistor planning to become one, put a stack of works by bona fide historians not crackpot real histories by reality celebrities on your bedside table, or download them to your Kindle. Give real history books to the people you love. Even those you only like.

You dont need to hear from Faulkner or MarxsEighteenth Brumaireyet once again to know that history isnt going away, any more than time is.

If you think were running out of time, or future, in which to solve our dilemmas, youve got plenty of company. With apologies to Walt Kelly: We have met the future and it is us.

You can follow me on Twitter @WmGermano. I promise not to use all caps.

See more here:

Futurist Shock - Chronicle of Higher Education (subscription) (blog)

Freedom of Association Takes Another Hit – Cato Institute (blog)

To see how little is left of one of our most important rights, the freedom of association, look no further than to todays unanimous decision by the Washington State Supreme Court upholding a lower courts ruling that florist Baronelle Stutzman was guilty of violating the Washington Law Against Discrimination (WLAD) when she declined, on religious grounds, to provide floral arrangements for one of her regular customers same-sex wedding. The lower court had found Stutzman personally liable and had awarded the plaintiffs permanent injunctive relief, actual monetary damages, attorneys fees, and costs.

This breathtaking part of the Supreme Courts conclusion is worth quoting in full:

We also hold that the WLAD may be enforced against Stutzman because it does not infringe any constitutional protection. As applied in this case, the WLAD does not compel speech or association. And assuming that it substantially burdens Stutzmans religious free exercise, the WLAD does not violate her right to religious free exercise under either the First Amendment or article I, section 11 because it is a neutral, generally applicable law that serves our state governments compelling interest in eradicating discrimination in public accommodations.

We have here yet another striking example of how modern state statutory anti-discrimination law has come to trump a host of federal constitutional rights, including speech, association, and religious free exercise. Its not too much to say that the Constitutions Faustian accommodation of slavery is today consuming the Constitution itself.

Consider simply the freedom of association right. That liberty in a free society ensures the right of private parties to associate, as against third parties, and the right not to associate as wellthat is, the right to discriminate for any reason, good or bad, or no reason at all. The exceptions at common law were for monopolies and common carriers. And if you held your business as open to the public you generally had to honor that, though you still could negotiate over services.

Slavery, of course, was a flat-out violation of freedom of associationindeed, it was the very essence of forced association. But Jim Crow was little better since it amounted to forced dis-association. It was finally ended, legally, by the 1964 Civil Rights Act. But that Act prohibited not simply public but private discrimination as well in a range of contexts and on a range of grounds, both of which have expanded over the years. The prohibition of private discrimination was probably necessary at the time to break the back of institutionalized racism in the South, but its legacy has brought us to todays decision, where florists, bakers, caterers, and even religious organizations can be forced to participate in events that offend their religious beliefs.

Courts havent yet compelled pastors to officiate at ceremonies that are inconsistent with their beliefs, but we have heard calls for eliminating the tax-exempt status of their institutions. Such is the wrath of the crowd that wants our every act to be circumscribed by lawtheir law, of course. And theyre prepared, as here, to force their association on unwilling parties even when there are plenty of other businesses anxious to serve them. As I concluded a Wall Street Journal piece on this subject a while ago:

No one enjoys the sting of discrimination or rejection. But neither does anyone like to be forced into uncomfortable situations, especially those that offend deeply held religious beliefs. In the end, who here is forcing whom? A society that cannot tolerate differing viewsand respect the live-and-let-live principlewill not long be free.

Amen.

Go here to read the rest:

Freedom of Association Takes Another Hit - Cato Institute (blog)