Space whisperers: the Aussies guiding Cassini’s suicide mission to Saturn – The Guardian

On 15 September 2017 at about 10pm AEST, Nasas Cassini spacecraft will plunge deep into the hostile atmosphere of Saturn on an historic but suicidal course. Its the grand finale of a 20-year mission which has revolutionised our understanding of the solar system and sent home more than a quarter of a million stunning images of Saturn and its moons.

Cassinis instruments will be running to the last, capturing every possible byte of data from its closest encounter with the ringed planet before it ultimately evaporates.

Some 1.2bn km away, in a valley just outside Canberra, Glen Nagle and his colleagues will be listening intently to what he calls the whispers from deep space. Im going to be here for 24 hours and I wont be sleeping, he says enthusiastically.

Nagle (pictured above) works at the the Canberra Deep Space Communication Complex, aka Tidbinbilla Tracking Station, home to four antennas which help track and command the many spacecraft in our solar system. Run by CSIRO, Australias national science agency, but funded by Nasa, Tidbinbilla is one of just three stations in Nasas Deep Space Network (the others are in California and Madrid) and it is here that Cassinis final radio signals will be received and relayed to a global audience.

Were going to be responsible for capturing Cassinis last breath of data, Nagle says. Itll be a bittersweet moment.

Nasa cant do it without us because the other stations are completely facing in the wrong direction. Saturn will be in our skies, our field of view. Its literally the way the planets have aligned.

Opened in 1965, Tidbinbilla is a serene station enveloped by national parks. Its a place where the low hum of the moving antennas and the occasional paging announcements are the only sounds that punctuate the silence.

The dishes look surprisingly small from a distance, dwarfed by nature itself, but up close their scale is imposing. The largest is 70m in diameter and 109m across its curvature you could throw a football field into it, Nagle says and weighs about 4,000 tonnes. They are almost millimetre-perfect parabolic surfaces.

Each dish acts as both a gigantic ear and a gigantic loudspeaker, telling the spacecrafts how to behave, ensuring their health and collecting their data. The dishes operate night and day, whether or not the skies are clear to the naked eye.

At the present time we, Earth, have about 30 missions in the solar system, so about 40 individual spacecraft, Nagle says. We communicate with them using radio waves the invisible part of the electromagnetic spectrum.

Spacecraft receive and transmit data as digital ones and zeros. Its the same way that your phone receives a radio signal before your phones software turns it back into a picture, its just those ones and zeros. We dont know whether the stream were receiving is a beautiful picture or some instrument data or some engineering data or whatever it is.

The DSN doesnt handle satellites in Earths orbit the kind that are used for mobile communications, observation, weather prediction, GPS and so on. Theyre literally too close for us, Nagle explains. We just talk to the missions that have headed out across the solar system.

The furthest of them, Voyager 1, is so far from Earth that it seems a minor miracle its signal can be heard at all. For Nagle, a self-confessed space buff since childhood who is now the outreach and administration lead at Tidbinbilla, its a thrilling thought.

Right now Voyager 1 is roughly 20.7bn km away and moving further away by about 1.4million km every day, he says. Thats about four and a quarter times further away than Pluto. So its way out there. It takes over 30 hours to get a signal there and back.

To give you some idea of what that signal is like now: Voyager transmits at around 19 watts, about half the power its taking to run the lightbulb in your fridge. So imagine already trying to see half your fridge light from four and quarter times as far away as Pluto youre not going to see it.

And it gets even smaller because as that signal travels across that 20bn km of space it spreads out, it becomes thinner and more diffuse.

In fact, he adds excitedly, the signal we get is equivalent to only about one twenty billionth billionth with a b! of the amount of power thats generated by a typical watch battery. But youre still getting the information, the ones and zeros, and even though its very weak all of the information is still there.

Up high on dish number DSS35, theres a minor problem which needs to be fixed. The ball gears are not meeting correctly and the dishs ability to slowly pivot as it must do to track the craft while the Earth rotates is being compromised.

Currently were inserting a bit of solder to measure the backlash in the gear, says antenna technician Michael Murray. We measure the crush on the solder and thatll give us an idea of what the backlash is.

As with everything in space exploration, precision counts. And yet, oddly, just a few metres away theres a kink in the safety rail where a section has been cut away and awkwardly repositioned.

John Howell, the survey electronics technician, laughs. When they built this antenna they realised the rail was in the way and they had to cut this out [for the dish to be able to fully rotate]. We do months and months of testing when things are first built, we move everything very slowly, and when they got to this bit they realised, Oh no, its not going to work. We blame the engineers.

Howell has been employed at Tidbinbilla by CSIRO for the past 15 years the same duration as Nagle but, unlike his colleague, his knowledge of the science is more cursory.

People ask me what are they tracking today and I say, Ive got no idea. As long as my things point to where theyve got to point ... I mean, when weve got a major level one support happening like the Mars rovers landing or Cassini then its quite interesting, but apart from that some of the scientific stuff is way above my head.

He adds: But I am interested in the Voyager probes. It takes forever to get a signal to them and back at the speed of sound light, Nagle interrupts apologetically Oh sorry, the speed of light! Howell continues.

They left when I was still in primary school. I find it hard to believe we can talk to something that far away. It blows my mind.

In the recently built control centre a place Matthew Purdie, senior link controller, describes as the heart of the station activity is decidedly slow. You might imagine a hive of scientists huddled around monitors awaiting fresh data but in fact theres only one CSIRO scientist based at Tidbinbilla and his research role is detached from the day-to-day communications performed on behalf of Nasa and the other space superpowers. Nasas scientists are located at the Jet Propulsion Laboratory in the US.

Purdie and his team of controllers are patiently monitoring banks of screens, waiting for the rare occasion when a command fails or for the more alarming news that a craft has become inoperable or gone missing. Occasionally they have to call the JPL to tell them their craft are sick.

We refer to ourselves as coiled springs, Purdie says. Were sort of employed to handle things when they go wrong. Most of the time were looking for green on our screens. If everythings green were good; if it goes orange or red were in trouble.

Behind him, a box of on one of his screens turns orange. Oh, thats nothing to worry about, he says assuredly. Thats a carrier out of lock. Its spacecraft 74. We lost the signal but it was an expected loss of signal because the craft occultated it went behind Mars.

Right now Im on antenna DSS34, so Im tracking three spacecraft: MRO [Mars Reconnaissance Orbiter], Maven and Mars Odyssey. Id have to get out the book to tell you exactly what each spacecraft is doing. We know the technical side of our spacecraft, what bit rates they use, command frequencies and all that stuff, but quite often we forget why theyre there.

Purdie knows plenty about Cassini, however, and has been on duty for some of its recent dives the series of 22 daring orbits between Saturn and its rings which have given the craft a unique perspective on the planet and the surrounding bands of dust, rock and ice.

Disappointingly, Purdie already knows his shift patterns will cause him to miss the finale next month. Hes tempted to come to work anyway.

I like being part of history and science, he says. I like the fact that Ive been here for landings and launchings and things like that. Years ago they used to go around to each of the stations and ask for a Go? No go?, so youd have to say, DSS45 is a go! That was so cool, I loved doing that. They dont do that any more.

Australias involvement in space exploration is six decades old and even though Nagle thinks Australia doesnt see itself as a space-faring nation it has played a critical role in some of the most inspiring moments in the history of humankind.

The dish out the front is the one from Honeysuckle Creek that received and relayed to the whole world the first pictures of Neil Armstrong walking on the moon in 1969, Nagle explains. He must have regaled people with the full story a thousand times or more, yet he makes it sound anything but tiresome.

Nasas original intention was to use their dish in California to transmit the pictures to the world and show America winning the space race, he says. When Neil came out of the spacecraft the first thing he needed to do was switch on a camera which was mounted upside down so that he could later pick it up with his big, gloved hand. Nasa were going to flip the picture but the video technician called in sick that day and his backup forgot.

Eventually they flipped it but it was highly contrasted because the signal was going to ground somewhere. Mission control couldnt show that to the world and Neil wasnt going to wait.

At the critical moment, Honeysuckle Creek had a perfect image. When Nasa saw that, Nagle continues, they flipped the switch to Australia and 600 million people around the world watched Neil come down the ladder, put his left foot on the surface of the moon and say, One small step for man, one giant leap for mankind.

I was an eight-year-old kid sitting in front of the television, glued to the screen, watching humans walk on the moon in glorious black and white. I had no idea that 40 years later Id be working at the place where I can look out of my window at the dish that brought me those pictures.

That enduring sense of wonder is shared by Greg Boyd, the senior network administrator at Tidbinbilla.

I love the science, he says. When I first started I was into everything. We used to have these things called twixes, well before we had emails. They were advisories about what was happening and Id be reading all this groovy stuff thats going on.

As time goes on you become blase. Not jaded; blase. But Im doing my dream job and Ive been doing it for the last 25 years. Where else can a boy from Australia work for Nasa and really be critically involved in their missions? This is it.

As night falls over Tidbinbilla, low-lying clouds initially block the views overhead. A group of kangaroos gathers by the perimeter fence, intrigued by the faint, eerie noises emanating from the site.

By 3am the clouds have finally dissipated and the vast, star-spangled sky is simply breathtaking. Somewhere out there, Cassini is looping the loop between Saturn and its rings.

In its lifetime Cassini and its accompanying probe, Huygens, have revealed many of the secrets of the Saturnian system: how the particles that make up Saturns rings range in size from smaller than a grain of sand to as large as mountains; how Titan, one of the moons, has prebiotic chemistry as well as rain, rivers, lakes and seas; how icy plumes of water are spraying upwards from tiger stripe fractures on Enceladus, an otherwise frozen moon.

It has also witnessed giant hurricanes at both of Saturns poles and captured the first complete view of the north polar hexagon not bad for a one megapixel camera. The finale should reveal yet more about the interior of the planet as the craft measures its gravity and magnetic field.

The decision to hurl Cassini into Saturns deadly, gaseous atmosphere next month has been made through necessity and responsibility. The craft has run out of fuel and contains a nuclear battery; Nasas scientists fear it might contaminate one of the surrounding moons should it crash into them.

We have to dispose of the spacecraft safely, says deputy project scientist Scott Edginton, whos based in California, because Titan and Enceladus have been shown to be places where there are conditions for habitability, conditions that we think are appropriate for life.

So our navigators came up with this series of grand finale orbits, flying through the gap between the planet and the rings, and eventually ending in Saturns atmosphere. When the scientists saw that plan they were like, Wow, this is unexplored territory, were going to learn so many new things. So starting April this year we entered into the grand finale orbits. Its hard to believe were almost done.

Of the final descent, he says: Think of it as were sniffing the atmosphere. It will set the ground truth for past measurements and even future measurements. Thats something Im really looking forward to.

At Tidbinbilla the following morning, the anticipation in the visitors centre is just as palpable. Its this generations Voyager, says Jonathan Kent, a self-proclaimed hack astronomer. I think its capturing peoples minds and hearts and reinvigorating our interest in space.

Ten-year-old Scout Miller is proof. Shes at the centre with her family, and talk of the discoveries made by Cassini and Juno Nasas mission to Jupiter which delivered a tranche of close-up images of the planets red spot has made her wonder what else might be out there.

There must be alien life, she says. We cant be the only people. It cant just be a coincidence that we just appeared and no one else has, and that this is the only planet with the right things for life.

Many of CSIROs staff at Tidbinbilla share her optimism and, even though Nagle forewarns that life may never be found due to the sheer scale and age of the universe, he says: It would be a fantastic thing to find because it would answer the most fundamental questions we have: Is it just us? Are we alone? Is the universe full of life? Are we the first life? Are we the last?

Future missions to Saturn and its moons may yet reveal some answers, but for Cassini the deadly denouement is imminent.

Cassinis going to end its life as a shooting star in the atmosphere of a giant ringed world, says Nagle. Theres no more poetic way for a spacecraft to finish what has been a magnificent mission.

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Space whisperers: the Aussies guiding Cassini's suicide mission to Saturn - The Guardian

Photographer quits his DJ career – Trance Hub (satire) (press release) (blog)

Dmitry Chumak, better known as Photographer has apparently quit his DJ career. The Ukranian star was recently supposed to play at the 2017 beach edition of Quest for trance. However, just a while ago they announced that Photographer has quit his DJing career and hence wont be playing at the festival.

Were sorry to announce that tomorrow, at our Quest4Trance the beach edition 2017 event at Elements Beach,

Posted by Quest4Trance onFriday, August 11, 2017

Well, the reason for this is unknown and there has been no official confirmation from Dmirty himself. So, we cant really say much at the moment. It is extremely upsetting to see such talented producers and DJs quitting these days. We hope it is just a temporary phase and he returns back soon.

Trance enthusiast. Armada Ambassador. Content writer. Im not afraid of 138! Making people give Trance a chance.

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Deadpool’s Tim Miller Lands Gig As Director of Adaptation Of Cyberpunk Novel Neuromancer – LRM Online (press release) (blog)

The world just a little bit bleaker the day we learned that Deadpool director Tim Miller would be dropping out of Deadpool 2. Deadpool was a film thats been a long time in the making, and the fact that one of its key architects wouldnt be around for the second one was a bit of a gut punch to fans of the first. However, there was a bright side to this sad bit of news. While Miller would no longer be involved in Deadpool, it did open him up to work on other big projects.

Not long after, it was revealed that he was in early talks to direct an eventual reboot of James Camerons The Terminator. However, with the rights still not set to revert back to Cameron until 2019. Another project Millers been attached to is the adaptation Influx, though the current status of that is unknown. Now, Miller is attached to yet another novel adaptation.

RELATED:WHOA! Cameron Coming Back For A True TERMINATOR 3? With DEADPOOL's Tim Miller?!

According to Deadline, Miller is on board to direct Neuromancer, a cyberpunk film from sci-fi author William Gibson. The synopsis for the novel on Amazon is as follows:

No screenwriter is currently set to adapt the story, but the studio is working on setting someone up as we speak. On board to produce is X-Men: Dark Phoenix director Simon Kinberg.

Between Terminator, Influx, and now Neuromancer on Millers plate (not to mention his producing Sonic the Hedgehog), it seems like the filmmaker has lined up the next few years quite nicely. As of right now, each of these projects are in various states of development, so we wouldnt be surprised if he were to tackle all these films over a 2-3 year period, which would make for quite the packed release schedule down the line.

Are you excited to see Miller join another project? Let us know your thoughts down below!

SOURCE: Deadline

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Deadpool's Tim Miller Lands Gig As Director of Adaptation Of Cyberpunk Novel Neuromancer - LRM Online (press release) (blog)

Cyberpunk Classic Neuromancer Might Become A Movie From Deadpool Director – GameSpot

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A movie version of William Gibson's hugely influential sci-fi novel Neuromancer has been in development many times over the years, but has yet to make it to the screen. It has now been reported that another attempt is being made to adapt the classic book, with Deadpool's Tim Miller tapped to direct.

According to Deadline, Miller and his VFX studio Blur will develop the movie at Fox. Miller was initially set to direct Deadpool 2 for the studio, but disagreements with star and producer Ryan Reynolds led to his departure in October last year. The site reports that Fox has been looking for a major project for Miller since then. X-Men producer Simon Kinberg is set to produce.

Miller is the latest filmmaker to be attached to a potential Neuromancer movie. Directors Chris Cunningham and Chuck Russell previously worked on different versions of a script, while music video director Joseph Kahn was attached to the project in 2007. The film got closer in 2010 when Vincenzo Natali (Cube, Splice) was hired to work on it. His version was still in development as late as 2013, with a script co-written by Gibson.

Neuromancer was first published in 1984. It tells the story of a veteran computer hacker who is hired by a mysterious employer to perform a dangerous, almost-impossible hack. The novel is now considered one of the most important works of the cyberpunk genre and is also notable for popularizing the term "cyberspace."

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Cyberpunk Classic Neuromancer Might Become A Movie From Deadpool Director - GameSpot

Can This Stock Price Climb The Ladder: EDAP TMS S.A. (NASDAQ … – FLBC News

Moving 0.37% from the most recent open, shares ofEDAP TMS S.A. (NASDAQ:EDAP) have landed on investor watchlists as the latest bid puts the equity at$2.70. Investors interested in stocks under $5 have given this stock a second look over the past few weeks.

Most investors are likely looking for that next stock that is ready to take off running. Maybe the focus is on finding a stock that has recently taken a turn for the worse for no real apparent reason. As we all know, as quickly as a stock can drop in price, it can bounce back just as fast.

Although the popular stocks that receive a high level of media coverage tend to recover quicker after a sell-off, there may be plenty of under the radar stocks that are ripe for buying. Scoping out these potential market gems may help repair a portfolio that has taken a hit for any number of reasons.

The average investor might not have the time to monitor every single tick of a given stock, but taking a look at historical performance may help provide some valuable insight on where the stock may be trending in the future. Over the past week, EDAP TMS S.A. (NASDAQ:EDAP) has performed -8.47%. For the past month, shares are -15.63%. Over the last quarter, shares have performed 6.73%. Looking back further, EDAP TMS S.A. stock has been -14.42% over the last six months, and -17.68% since the start of the calendar year. For the past full year, shares are -11.18%.

There is rarely any substitute for diligent research, especially when it pertains to the equity markets. No matter what strategy an investor employs, keeping abreast of current market happenings is of the utmost importance. Everyone wants to see their stock picks soar, but the stark reality is that during a market wide sell-off, this may not be the case. Recently, shares of EDAP TMS S.A. (NASDAQ:EDAP)have been seen trading -9.46% away from the 200-day moving average and -15.55% off the 50-day moving average. The stock is currently trading -29.87% away from the 52-week high and separated 20.00% from the 52-week low. EDAP TMS S.A.s RSI is presently sitting at 27.14.

New investors may sometimes be working with limited capital. Choosing which stocks to own can be a tough decision. Individuals may be deciding on whether to buy 10 shares of a stock trading at $100 as opposed to purchasing 100 shares of a stock trading at $10. We have recently been focusing on stocks that are trading under the $10 price level. We are constantly monitoring technical and fundamental factors that may lead to breakouts for these relatively cheap (in terms of price) stocks.

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In the Future, Humans Will Use Brain to Brain Communication and Download Their Memories If Elon Musk Has His Way – Newsweek

Elon Musk wants to get inside your head. In April, the Silicon Valley billionaire announced plans to launch Neuralinka company dedicated to developing a brain-to-machine interface to cure brain ailments like paralysis and memory problems and help people compete with robots when the artificial intelligence revolution makes human brains obsolete. Musk says this will be accomplished by implanting tiny electrodes into the brainallowing for things like downloading and uploading memory and casual brain-to-brain communication.

Leaders in the neurotechnology field welcome Musks arrival, while neuroethicists and others urge caution. The endeavor may sound like science fiction, but its feasible, says Timothy Deer, president of the International Neuromodulation Society, a nonprofit group of researchers and developers dedicated to using spinal cord stimulation to treat neurological pain. The cochlear implant was invented 20 years ago, and with electricity and the right frequencies targeting the brain, it allows people to hear, he says. That sounded impossible back then. And great gains require great brains, Deer says. Ben Franklin didnt know how to harness electricity, but he and others knew it was the key to something. Now, we know how to use electricity in very specific ways. Its exciting to see how Mr. Musk might change how we think.

Humans have been trying to mess with their brain waves to solve diseases since ancient times: The Romans and Greeks used to put electric fish on top of their heads to relieve pain, says Ana Maiques, CEO of Neuroelectrics, a company that develops noninvasive wireless brain monitoring and stimulation technologies.

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Elon Musk, chairman and chief executive officer of Tesla Motors Inc., gestures as he speaks during a news conference in Fremont, California, on September 29, 2015. David Paul Morris/Bloomberg/Getty

Maiques is happy Musk has entered the neurotech field. With new technologies, including artificial intelligence, there is a lot of room for startups and new companies, she says.

Jennifer French, co-founder and executive director of Neurotech Network, a nonprofit that advocates for and educates the public about implantable technology, says investments in neuroscience and neurotechnology from the Brain Research Through Advancing Innovative Neurotechnologies Initiative started by the Obama administration have been critical in exploring the brains mysteries.

Zack Lynch, founder of Neurotechnology Industry Organization, a global trade association representing companies involved in neuroscience and brain research, says, The [human] brain is the most complicated organ on the planet. The neurotechnology industry produces $165 billion in yearly revenue, he says, but 90 percent of that revenue comes from pharmaceuticals for neurological disorders like Lou Gehrig's disease, or amyotrophic lateral sclerosis, as well as post-traumatic stress disorder and depression. Annual revenue from neurological devices is about $10 billion.

If Musk is successful, he will run into a swamp of ethical issues. Neuroscience raises questions about technology, art, entertainment, warfare, religion and what it means to be human, Lynch says. And these considerations will be difficult to address in the short term, says Peter Reiner, professor and co-founder of the National Core for Neuroethics. Most important is privacy of thought. When a computer is hooked up to me and knows what Im thinking, that becomes a very challenging area to navigate. Another issue is what Reiner calls reason bypassing. If a device can influence your brain without you perceiving it, are you really making your decisions? He believes society already faces these questions with smartphones: Advertisers are collecting information about users based on their browsing habits and then using that data to try to change their behavior.

Daniel Wilson, a best-selling author and robotics engineer, considers these ethical issues in his novel Amped, which predicts that neurotechnology will cure people with mental disabilities and eventually help them leapfrog beyond human ability. The amplified humans known as amps are then discriminated against because the public fears their abilities.

Wilson believes brain-to-machine interfaces will become common, but that they will not diminish the humanity of their users. People often look at human creations, and we call them unnatural, Wilson says. But from my perspective, theres nothing more natural than a human being creating a tool. Birds nests or anything animals do instinctively always seems natural, but we consider it unnatural when a human uses a tool. Thats the most natural thing that a human can do. To put that tool in our bodies is a completely natural extension of what weve been doing for millennia.

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In the Future, Humans Will Use Brain to Brain Communication and Download Their Memories If Elon Musk Has His Way - Newsweek

Fast facts about cloning – WPSD Local 6: Your news, weather, and sports authority – WPSD Local 6

(CNN) -- Here's some background information aboutcloning, a process of creating an identical copy of an original.

Facts: Reproductive Cloning is the process of making a full living copy of an organism. Reproductive cloning of animals transplants nuclei from body cells into eggs that have had their nucleus removed. That egg is then stimulated to divide using an electrical charge and is implanted into the uterus of a female.

Therapeutic Cloningis the process where nuclear transplantation of a patient's own cells makes an oocyte from which immune-compatible cells (especiallystem cells) can be derived for transplant. These cells are stimulated to divide and are grown in a Petri dish rather than in the uterus.

Timeline: 1952 - Scientists demonstrate they can remove the nucleus from a frog's egg, replace it with the nucleus of an embryonic frog cell, and get the egg to develop into a tadpole.

1975 -Scientists get tadpoles after transferring cell nuclei from adult frogs.

1986 -Sheep cloned by nuclear transfer from embryonic cells.

February 22, 1997 -Scientists reveal Dolly the sheep, the first mammal to be cloned from cells of an adult animal. She was actually born on July 5, 1996.

1998 -More than 50 mice are reported cloned from a single mouse over several generations. Eight calves are cloned from a cow.

2000 -Pigs and goats are reported cloned from adult cells.

2001 -Advanced Cell Technology of Worcester, Massachusetts, says it produced a six-cell cloned human embryo, in research aimed at harvesting stem cells.

2001 -Five bulls are cloned from a champion bull, Full Flush.

2002 -Rabbits and a kitten are reported cloned from adult cells.

December 27, 2002 - Clonaid claims to produce first human clone, a baby girl, Eve.

January 23, 2003 -Clonaid claims to have cloned the first baby boy. The baby was allegedly cloned from tissue taken from the Japanese couple's comatose 2-year-old boy, who was killed in an accident in 2001. Clonaid has never provided physical evidence of the cloning.

February 14, 2003 -The Roslin Institute confirms that Dolly, the world's first cloned mammal, was euthanized after being diagnosed with progressive lung disease. She was 6 years old.

May 4, 2003 -The first mule is cloned at the University of Idaho, named Idaho Gem.

June 9, 2003 -Researchers Gordon Woods and Dirk Vanderwall from the University of Idaho and Ken White from Utah State University claim to have cloned a second mule.

August 6, 2003 -Italian scientists at the Laboratory of Reproductive Technology in Cremona, Italy, say they have created the world's first cloned horse, Prometea, from an adult cell taken from the horse who gave birth to her.

September 25, 2003 -French scientists at the National Institute of Agricultural Research at Joy en Josas, France, become the first to clone rats.

February 12, 2004 -South Korean researchers report they have created human embryos through cloning and extracted embryonic stem cells. Findings by a team of researchers were presented to South Korean scientists and describe in detail the process of how to create human embryos by cloning. The report says the scientists used eggs donated by Korean women. An investigative panel concludes in 2006 that South Korean scientist Woo Suk Hwang's human stem cell cloning research was faked.

August 3, 2005 -South Korean researchers announce they have successfully cloned a dog, an Afghan hound named Snuppy.

December 8, 2008-April 4, 2009 -Five cloned puppies from Trakr, a German Shepherd Sept.11 Ground Zero rescue dog, are born.

May 2009 -Clone of Tailor Fit, a two-time quarter horse world champion, is born, one of several cloned horses born that year.

September 29, 2011 -At South Korea's Incheon Airport, seven "super clone" sniffer-dogs are dispatched to detect contraband luggage. They are all golden Labrador Retrievers that are genetically identical to "Chase," who was the top drug detention canine until he retired in 2007.

May 15, 2013 -Oregon Health & Science University researchers report in the journal Cell that they have created embryonic stem cells through cloning. Shoukhrat Mitalipov and the biologistsproduced human embryos using skin cells, and then used the embryos to produce stem cell lines.

April 2014 -For the first time,cloning technologies have been used to generate stem cells that are genetically matched to adult patients.Researchers put the nucleus of an adult skin cell inside an egg, and that reconstructed egg went through the initial stages of embryonic development, according to research published this month.

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Game of Thrones’ Isaac Hempstead Wright on Bran’s Evolution, House Music and Becoming a Meme – Paste Magazine

While much of the Game of Thrones cast has morphed from the innocence of the first season to the militarized cynicism of its seventh, none have undergone as striking a transformation as Isaac Hempstead Wrights Bran Stark. The precocious little spider monkey whose climbing excursions effectively caused the War of the Five Kings has become a stoic, omniscient weirdo after his travels beyond the Wall. Everyone else is enjoying the brief and bittersweet pleasures of reunion; Bran is trying to continue being a human being rather than Westeros first computer filing system. That has meant changes for both Wright and his now one of the most fascinating on the series as we reach the beginning of the end. At a joint AT&T and HBOevent, Paste sat down with Wright to talk Game of Thrones, memes, and what he can see of his future.

Paste: I heard that you were a bit of a meme aficionado. Have you been browsing Twitter after each episode?

Isaac Hempstead Wright: Ive seen a lot of memes. Amongst the abuse I got after episode three [The Queens Justice]so much hate after that. Oh Bran, I hate Bran now. Hes changed so much. Guys, chill the fuck out. Its alright.

Paste: Do you contribute to the discussion secretly?

Wright: I dont, Im purely an observer. But all I do with my girlfriend is send memes to each other. She got so excited when she found one of me. Isaac, youre in a meme! Yeah, Im in a meme. [Bran] has become very meme-able. Ive seen some great ones, like one where Meera goes, My brother died for you, Hodor died for you, and Bran says, New phone who dis?

Paste: Has this character change affected you professionally? A big acting step up?

Wright: It was really interesting to do, because in many ways, for me at least, Bran has been playing either a child or a teenager. Obviously with some unique and weird bits, but as Ive grown up, its basically just been me in a different time period. Theres things you can bring into it, with this and other parts, but now theres nothing you can possiblyIm not arrogant enough to think I know everything. We had a couple meetings with the producers David Benioff and D. B. Weiss, and we modeled it on Dr. Manhattan from Watchmen. We called it Dr. Branhattan. This idea of existing at all these different times and tuning into all these moments.

Paste: I know youve also learned from Max von Sydows performance as the previous three-eyed raven. How are you doing it differently?

Wright: I didnt want it to be just like Max von Sydow because that three-eyed raven had been sitting in that tree for a thousand years. Bran hasnt. Hes not that old. Hes just been given all this craziness now. Theres no point in trying to pretend that hes immediately become wise. Hes obviously become wise, but he hasnt had time to sit there and go through all the history. The way it works, this whole vision thing, isnt that he knows everything immediately. He has access to everything. So where that raven has sat there for a million years and has everything at his fingertips, Bran doesnt yet. So we didnt want him to be this, Oh, I know everything and Im all stoic sort of guy. Hes still a kid, just with a unique power.

Paste: He and Samwell Tarly (John Bradley-West) are really the only ones dealing with the world by sitting and learning quietly.

Wright: Yeah, its really nice. Its nice being one of the representatives of the intellectuals of Westeros. People using knowledge as power.

Paste: In the past youve said that you plan on pursuing a PhD in the futureis that still important to you?

Wright: Somebody put this PhD thing on WikipediaIm not doing a PhD. I am going to university for joint honours in music and maths. Music theory mainly. I just did my Grade 8 Music Theory this year.

Paste: Have you gotten to do your composition theory stuff yet?

Wright: Yeah, Ive been composingIm friends with Ramin Djawadi, our composer, and Ive been with them on some of the tours theyve done of all the music. Whenever were at an event, we just sit in a corner and talk music.

Paste: Did you and Kristian Nairn [who played Hodor in the series] bond over music?

Wright: Weve always been music pals. I managed for the first time its taken me agesto go see him DJ. Awesome. Im not really into house music, but it was really good.

Paste: Electronic music can get pretty close to classical though.

Wright: Oh, definitely! Steve Reich! I mean, Aphex Twin, even.

Paste: Going on to university, what lessons do you think youll take from your experience on Game of Thrones?

Wright: I think one of the most important things, with Bran anyways, is learning from massive mistakes. Bran basically killed everyone he held dear. But he didnt sit there and wallow and go, Oh, Im useless and cry in despair. He also didnt just brush it off. He took from it that he needed to be wiser and accepted that this was destiny. Theres no point getting upset. Which is a bit of a grandiose way of putting learn from your mistakes.

Jacob Oller is a writer and film critic whose writing has appeared in The Guardian, Playboy, Roger Ebert, Film School Rejects, Chicagoist, Vague Visages, and other publications. He lives in Chicago, plays Dungeons and Dragons, and struggles not to kill his two cats daily. You can follow him on Twitter here: @jacoboller.

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Game of Thrones' Isaac Hempstead Wright on Bran's Evolution, House Music and Becoming a Meme - Paste Magazine

Monongahela robotics engineer finds time for trio of diverse pursuits – Observer-Reporter

While Rich Pantaleo studied mechanical engineering at Carnegie Mellon University, one of the electives he chose was a class in photography. He also joined the robotics club.

Together, the class and club paved the way for his current dual career owner of a photography enterprise and a robotics engineer for National Robotics Engineering Center, a research facility in Pittsburghs Lawrenceville neighborhood owned by CMU.

Hired shortly after graduating, Pantaleo, 30, has worked on some interesting robotics projects. One took him to South Africa for three weeks, where he was part of a team trying to develop a robotics system for mapping an underground platinum mining operation. Part of that effort also took him to Croatia, where he worked with a mining company to turn a remote-controlled dozer into a fully automated one.

Another trip, this time to California, had him work in the strawberry fields designing a robotic plant sorting system. Another project had him design a sensor pod for the remote measurement of steel slabs for a steel mill in Illinois.

For the military, he worked on a team that created a robotic wheel that enables vehicles to move through a wide variety of terrain swamp, desert, and dirt and paved roads. Currently, hes engrossed in a project for the Defense Advanced Research Projects Agency to improve the survivability of military vehicles.

Traditionally, the answer to improved survivability was to add more armor, but in this age of advanced weaponry that is not always practical, he said. Instead, were working on a robotic shield that can move in front of an incoming ordnance.

Pantaleo said he always loved making things with his hands, which is why he likes robotics for its hands-on attributes. As a child, his maternal grandfather, George Karabin, a master carpenter for Donora Lumber Co., taught him how to use hand tools. This eventually led to his woodworking interests, which initially saw him making serving trays for family as Christmas gifts.

For the last 10 years, hes been turning out furniture (end and coffee tables, lamps, a clock case and serving trays) at his Monongahela home workshop that he gives to friends as wedding presents.

In addition to his work and furniture-making, he is now focusing on photography.

I started taking photos in high school with a digital camera at a time when I was an avid rail fan, he said. I saw awesome rail photos on the internet, wondered if I could do the same and drove around taking photos of locomotives.

A breakthrough moment came about when he enrolled in a black-and-white photo class at CMU.

There, I performed the rites of passage of photography: shooting on an SLR, developing my own film, making my own prints from negatives and working long nights in the darkroom, he writes on his photography website, http://www.monvalleyphotoworks.com. It let me see that photography could be an art form.

Pantaleo put his photographic endeavors on hold after the end of the photography class, partly because he no longer had access to the darkroom, partly because he was too involved with his engineering studies. But in 2012, with his student loans paid off, he invested in a new digital camera and resumed his picture-taking passion with a focus on the old industrial sites of the Mon Valley.

On his website, which he promotes through social media sites like Facebook, Instagram and Flickr, he sells prints of images hes taken from Greene County north to Pittsburgh. At the moment, he has between 800 and 900 photos for sale and also publishes an annual Mon Valley-themed calendar.

In the last couple of years, hes gone back to shooting on film rather than digitally and said hes fallen in love with the work he gets on medium format film.

I now take fewer photos, but the results are better, he said.

Theres yet another side to Pantaleos multifaceted interests, one he attributes to his father, Rich, a retired instrumental music teacher for Ringgold School District. His father encouraged all three of his children to play an instrument, and his childhood home was full of music.

Kate plays the flute, Regina plays the clarinet and I play trumpet and piano, Pantaleo said. In two annual concerts at Ringgold Middle School, Regina and I play in the Greater Monongahela Area Community Band, which my dad directs. I also play trumpet during the summer for Too Many Tubas at nursing homes and church festivals.

Putting his piano talents to the test, he also plays electric keyboard for the Indie rock band, Good Ship Gibraltar, at gigs in and around Pittsburgh. As if all his interests arent enough to fill up his appointment book to the max, he has another project he hopes to start on soon.

Ive been thinking of publishing a photo coffee table book on the coal mines of our region, he said. But I havent yet been able to work out the publication details.

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Monongahela robotics engineer finds time for trio of diverse pursuits - Observer-Reporter

Hands on: Nest Cam Indoor and Outdoor home security cameras – The Sydney Morning Herald

Nest's streaming cameras offer a great way to keep an eye on things back at the ranch, assuming your home broadband connection is up to the task.

Security cameras with real-time alerts aren't just for catching burglars in the act, they can also offer peace of mind if you've got school-aged children coming home to an empty house or pets who spend the day alone.

Consumer-grade streaming cameras have been around for years, and there are plenty to choose from, but smart home pioneer Nest adds a few clever features to help stand out from the crowd. At the same time Nest has also launched its smart smoke/ carbon monoxide alarm in Australia, but we're still waiting on the Nest Smart Thermostat.

The cameras aren't cheap; the Nest Cam Indoor and Outdoor models cost $319 each, plus there's the optional Nest Aware cloud-based monitoring service which costs $14 per month for the first camera and $7 for each subsequent camera with Nest throwing in 30 days for free.

Perhaps more importantly, Nest's streaming cameras can also take a high toll on your broadband connection which will be an instant deal-breaker in some homes.

Easy to set up

It's simple to link a camera to your home WiFi network and Nest account by downloading the iOS/Android Nest app and scanning the QR code on the back on the camera. As a fallback it's also possible to configure the cameras using a desktop browser.

Get the latest news and updates emailed straight to your inbox.

Both cameras are easy to install around your home, offering 1080p resolution and a 130-degree field of view thanks to a slight fisheye lens.

The Nest Cam Indoor features a flat magnetic base, along with a screw-in wall plate, so you can stick it pretty much anywhere as long as it's within range of your WiFi network and the 3-metre power cable can reach a wall socket.

You can stand the Indoor camera upright on a flat surface or attach it to the wall and then tilt the camera up and down, as well as twist it from side to side. There's the option to flip the image if you need to install the camera upside-down on the ceiling.

Meanwhile the Nest Cam Outdoor features a curved magnetic back and comes with a concave wall plate that has a 7.5-metre power cable. Once the camera is attached to the base it's easy to tilt it in any direction up to around 50 degrees. While the outdoor camera is weatherproof, Nest recommends not installing it in direct sunshine.

Keep an eye on things

You can access your cameras via the Nest mobile app or a desktop browser, with the option of two-factor authentication to help keep out uninvited guests.

While the cameras are handy for seeing what's happening at home right now, Nest's strength is its intelligent alerts system which can send emails or pop-up alerts to your phone. Unfortunately most of these features rely on you shelling out for a Nest Aware subscription each month.

Even if you don't have a subscription, each camera will notify you when it hears a noise or sees something move. You're not bombarded with messages every time someone walks in front of the camera, instead it notifies you at the first sign of activity after which it uses intelligent alerts to only notify you of "important activity".

You're sent a photo of the scene which isn't always very helpful if the culprit is far from the camera but you can click on the link to see a live feed.

At this point you can see and hear what's happening in the room and use two-way audio to speak to your unexpected guest, although the audio can be a bit unreliable (perhaps a bandwidth issue, although they were tested on 100/2 Mbps cable broadband). The picture is crisp and the cameras do a good job of coping with brightbacklights.They're infrared cameras, so they can still see clearly at night.

Stay Alert

Unfortunately you need a Nest Aware subscription if you want to see an instant replay or scroll back in time. Without this, the cameras will be of little use to some people.

To cut down on alerts, you can adjust the microphone sensitivity, or else disable sound or motion notifications completely. Nest Aware subscribers can also create custom zones within each camera's field of view, which is handy if you don't want to detect pets walking across the floor or trees moving outside the window. Nest Aware applies extra intelligent scene and audio analysis to reduce false positives, plus subscribers can save clips and create timelapse videos.

Nest Aware subscribers can also opt to only receive alerts when a person walks into the room, with smart image analysis able to recognise human movement (but not recognise specific faces, that requires the Nest Cam IQ which isn't sold in Australia). Subscribers can also take advantage of intelligent sound alerts, recognising people talking or dogs barking.

Private party

To further cut down on alerts and better manage your privacy you can schedule specific cameras to switch off at specific times of day. You can also automatically disable certain cameras when the Nest mobile app detects you're at home, although this chews through your smartphone battery like all GPS-enabled apps which monitor your location while they're running in the background.

Alternatively you can keep the cameras running but stop alerts when you're at home, which might be important depending on the types of events you're watching for.

Thankfully it's possible to add family members to your Nest account and control the cameras and alerts depending on who is home which is important if you don't want alerts on your phone when you go to the shops on the weekend while others stay at home.

Apart from smartphones, you can use Works With Nest-compatible low-powered Bluetooth GPS trackers to tell the cameras when you're home the kind of thing you could easily attach to house keys or a school bag.

If you don't live alone there are obviouslyprivacy and trust issues to be considered. The Nest Cams helped solve the mystery of my missing sunglasses; they were misplaced during a party so we went back to the video replay to find their hiding spot, but you can image how this power could be abused.

Look to the cloud

Unlike some security cameras the Nest Cams don't store any video onboard, instead they upload to the cloud constantly which obviously presents major challenges if your home is starved of bandwidth.

The upside of streaming to the cloud is that you can get an instant replay at any time or scroll back up to 30 days with thumbnails marking events of interest, but of course only if you're paying for the Nest Aware subscription.

The downside is that you're chewing through a hell of a lot of bandwidth, with that data probably counting towards your monthly usage limit. Even if you don't have a Nest Aware account, the cameras must upload constantly for you to receive alerts. With no onboard storage or backup power, the Nest Cams are useless if an intruder cuts the internet and/or power to your house before breaking in the window although you're sent alerts if your cameras are offline for a while.

In the picture

The cameras offer a sharp 1080p resolution with 8x digital zoom but even with a 2 Mbps uplink this wasdialled down to 720p by default, at which point a single Nest Cam is constantly uploading at 400 kbps leaping past 1 Mbps per second when something moves. At this rate a single camera will chew through around 120 GB per month.

These bandwidth demands are simply ludicrous in a country like Australia where many homes face monthly data limits and would be lucky to have access to 1 Mbps upload speeds. Thankfully you can adjust the picture quality to allow for your bandwidth, dialling it up to 1080p uploading at 1.2 Mbps and chewing through 300 GB per month or down to 360p (150 kbps, 30 GB per month).

Even at the lowest settings these bandwidth demands might still be too much if you have several cameras around your home, so you might curb their thirst by using the advanced settings to disable certain cameras at certain times.

Even if you're lucky enough to have access to the NBN you'd want to be on at least the 25/5 Mbps speed tier, as a basic 12/1 plan won't cut it. Heaven forbid everyone in your neighbourhood owns a few Nest Cams or your peak hour broadband traffic jams could get a lot worse.

So what's the verdict?

Like many American products, Nest Cams are designed for a world where data andbandwidth are seemingly infinite resources. In returnthe camerasoffer some impressive tricks but only if your home broadband can cope and you're prepared to shell out for the Nest Aware subscription.

To be fair some rivals also demand a monthly fee for cloud video storage, so it's important to do your research before taking the plunge. If you won't sign up for Nest Aware then your money is probably best spent elsewhere, especially if you'll be forced to dial down the picture quality so you're not making the most of the Nest Cam's 1080p resolution.

In a perfect worldNest Cams could be the perfect home surveillancetool, but for now they'll be impractical in many Australian homes until we sort out our nation's broadband woes.

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Hands on: Nest Cam Indoor and Outdoor home security cameras - The Sydney Morning Herald

How Maryland’s political parties ramped up their ground games for 2018 – Washington Post

With Marylands governorship and General Assembly seats at stake in the 2018 election, the states Democratic and Republican parties are both testing new approaches to outreach and working more vigorously than in the past to boost turnout in their favor.

Armed with lists of independents and party affiliates who sat out recent midterm elections, party volunteers and candidates are canvassing neighborhoods virtually every weekend to convince voters that the upcoming races matter, focusing largely on battleground districts but also reaching into each others strongholds.

Democrats, who outnumber Republicans by 2 to 1 in Maryland, want to oust Gov. Larry Hogan (R) and shore up their veto-proof majorities in both chambers of the General Assembly amid a surge of grass-roots activism and anger toward President Trump, who is deeply unpopular in the state.

Republicans are pushing to build on their 2014 success, when they captured the governorship in an upset and took over nine legislative seats during a year of record-low turnout for Democratic voters. They want to reelect Hogan and break the Democratic supermajority by flipping at least five Senate seats held by Democrats.

The challenge at this point for both political parties is to make sure your base remains engaged and committed, said John Willis, a University of Baltimore politics professor and former Maryland secretary of state who worked with past Democratic campaigns.

In 2014, voter turnout in the state dropped 11 percent compared with the previous gubernatorial election, including an 8 percent drop for registered Democrats. Some of the most significant declines occurred in Baltimore City, Montgomery and Prince Georges counties traditional Democratic strongholds.

Willis said registered Democrats could take back the governorship by increasing their turnout by four points, or about 80,000 people, noting that Hogan won the office with about 66,000 more votes than his opponent, then-Lt. Gov. Anthony G. Brown (D).

The key to 2018 is mobilization and getting back to normal, Willis said. The margin can be closed very easily with a mobilization effort.

To that end, the Democratic Party has embarked on a 10,000-household listening tour that will last through fall, asking residents what they want from elected leaders before developing an overarching message for upcoming elections. Then it will pivot toward trying to persuade voters to show up at the polls and back its nominees.

Old-fashioned neighbor-to-neighbor conversations is the most effective tool in politics these days, Maryland Democratic Party chair Kathleen Matthews said. Data is crucial, but in terms of a process, its all about building trust and conversations with people.

The Republican Party, flush with cash since Hogan took office and hoping down-ballot candidates can piggyback on the governors sky-high approval ratings, has been similarly active, deploying canvassers to swing districts with a new mobile app that flags residents who are likely to consider GOP candidates.

Its no secret were outnumbered in voter registration, but we believe we can capitalize on Hogans popularity and a tight data operation to make sure that our voters starting with Republicans but also independents and Democrats who will vote for Republicans from time to time are going to be there for us in the governors and General Assembly races, Maryland GOP chair Dirk Haire said.

Both parties are trying to win over people like Perry Rose, a 51-year-old computer programmer who lives in a working-class neighborhood of eastern Baltimore County. He voted consistently as a Republican in the past but now describes himself as an independent, saying he grew disenchanted with the GOP in recent years.

Del. Christian J. Miele (R-Baltimore County), who is running for state Senate and was the first 2018 candidate to receive backing from Hogan, worked Roses neighborhood during a recent canvassing effort this month.

Rose recognized Miele from a recent stream cleanup event and greeted the candidate as he neared his property with campaign brochures, but didnt commit to supporting him in the next election.

I dont know what you stand for, but I know youre a good person, and I can at least say youre at the top of my mind, he said.

Miele asked Rose to call him later so he could lay out his policy positions.

Thats why you door-knock because you dont know how someone like that is going to vote, Miele said. It sounds like hell support the person with the best ideas.

Frederick resident Heather Scott-Fagan is another potential prize for both parties. The 27-year-old lab technician, who said she typically votes only in presidential elections, described herself to Democratic canvassers this month as strongly left-leaning but named nonpartisan redistricting something Hogan has pushed for the past two years as a top priority.

When asked whether she wants to see Hogan reelected, she replied that she would rather see someone else.

Instead of waiting until after the primaries, the state Democratic Party has launched its field operations and voter outreach roughly a year in advance.

Trumps election has bolstered Democratic recruiting.

Daryl Martin, a 62-year-old editor for government contractors who knocked on doors with the Frederick group this month, said she has not been involved in campaigning since 1972, when she stuffed mailboxes for then-Democratic presidential nominee George McGovern.

I did that and just disappeared until this election, she said. I got angry and decided I needed to do something.

Martin and a partner knocked on 15 doors and reached four residents over nearly three hours, using printed spreadsheets that did not list homes in a geographical order.

Haire says the GOP mobile app, which uses data such as voting history and consumer habitsto determine which residents might vote for the partys candidates, gives them an advantage.

The day after Martins outing, Miele knocked on 35 doors in a two-hour period and reached five people, with his app providing logical routes.

The Democratic Party has similar technology but didnt use it during the Frederick outing this month.

Both organizations are uploading residents responses to survey questions to build their databases and identify supporters, opponents or those consideredpersuadable.

Both parties are focused on political battlegrounds such as Anne Arundel, Baltimore and Frederick counties, all jurisdictions that Hogan won convincingly in 2014.

In Marylands 2016 Senate race, then-Rep. Chris Van Hollen (D), who won the seat, defeated House Minority Whip Kathy Szeliga (R-Baltimore County) by 16 points in the Republican candidates home jurisdiction, but he lost in Frederick and Anne Arundel counties by 4.2 points and 1.4 points, respectively.

State Sen. Ronald N. Young (D-Frederick), one of the GOPs top targets for 2018, said he feels confident about winning reelection if turnout is strong in the largely Democratic city of Frederick. Last weekend, he led more than 20volunteers on a door-knocking campaign in his district.

Theres a good chance of some degree of a blue tide this time around, he said. Often during an off year, voters go the opposite direction of president, and this one is saying some things that could motivate people ... but Im not going to rely on that. Im going to concentrate on turning out the votes myself.

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How Maryland's political parties ramped up their ground games for 2018 - Washington Post

Creative Kids Day activities span clay to virtual reality – Goshen News

GOSHEN The monthly Creative Kids Day occurred Saturday at the Old Bag Factory in Goshen, offering stimulating activities from molding clay and exploring virtual reality to mixed media projects and more.

On the main level, Mark Goertzen, of Goertzen Pottery, had his pottery wheel spinning while he molded small clay cups. In the entry sat a table, a little lower for younger artists, with clay ready to work and mold.

"We have clay available for them to build to their own imagination," said Goertzen. "So we've had people making turtles. Someone did a pinch pot, and there have been other creatures made today. It's mainly exploring how clay is wonderfully malleable that you can form into shapes and things, to your imagination's content. It's just trying to get kids' hands dirty, and making something on their own."

While children can be a little timid in their approach, Goertzen said that doesn't usually last long.

"Kids naturally gravitate to clay, because you can just pinch it into any form they want," he said. "There's no right way to do it, and so conversely there's no wrong way to do it, so you don't have to worry about messing up just get messy."

On the second level in the complex, the Elkhart Art League, Second Song, The Train Exhibit and the Robotics Club were ready to interact with curious kids.

"Today's project is charcoals on tar paper, tar paper art," said Vice President of the Elkhart Art League Ellen Ridenour. "You have to start out with a circle, and you can go from there."

A few shop fronts down, a shop front with massage chairs and a virtual reality setup drew inquisitive minds.

Josh Ridenour heads the monthly Robotics Club on site at the Old Bag Factory during the last Saturday of each month, from 10 a.m. to noon. Leading with the virtual reality headset, the projects of the club go beyond designing robotics and navigating digital realities.

"These kids, and a bunch of other kids, have built this computer, this 3-D printer set, and we're starting to get into virtual reality," said Josh.

The virtual reality program allows users to explore the surface of Mars on the Mars Rover, disassemble and reassemble a jet engine and tour the International Space Station. One of the programs Josh uses to demo new users is an underwater exploration, where the user is beneath the sea near a shipwreck, getting acquainted with the wildlife nearby.

"Every kid should have access to this stuff. We make it available to all kids so nobody is left behind," said Josh.

Creative Kids Day is a monthly event at the Old Bag Factory, taking place from 11 a.m. to 2 p.m. the second Saturday of each month.

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Creative Kids Day activities span clay to virtual reality - Goshen News

How will Virtual Reality revolutionize Education? – Customer Think

There are good signs that 2016 would really be the year that virtual reality will be adopted widely, or at the very least the year that people star to see the development of a continuously expanding base of consumers and use cases. In the education industry, virtual reality would revolutionize how students learn, and the reason is simple. VR is not just a technology, it is a medium. Moreover, it will not only educate students about the past but also prepare them for the future, in particular jobs.

In the old days, textbooks were the only teaching tools that are used in transporting students to foreign lands or the solar system. Computers and tablets opened more opportunities, and even some video games. Now, virtual reality is letting kids experience historical places and planets like never before. For educators, virtual reality offers not only a chance to free students from the confines of school desks, exams and rote memorization, but helps improve their learning, via active participation and experience.

Education has not changed for years when it comes to teaching methods and approaches. These days, millennials feel pretty much comfortable with online learning, doing research on the web and resorting to instructional videos and distance learning that is provided by video technology. Virtual reality is obviously the next trend that will revolutionize the industry. Some VR projects used in schools and higher educational institutions are already under way. Education and technology are interconnected and this synergy could transform the world that people live in. The contradictory phenomenon is that even though an early adopter of technology, education is also one of the last sectors that is fully transformed by it, because of institutional inertia and several other reasons.

Virtual headsets and platforms are the new tools to inspire creative learning. Furthermore, the technology creates a world of imagination, which could break the boundaries in traditional learning. Nevertheless, its adoption needs not just time and effort, but completely elaborated methods to adjust the technology for the purposes of learning. Virtual game-based experience boosts students motivation. Keep in mind that motivation and engagement are major factors of game-based learning, and VR takes these to the next level. The very purpose of education is basically a key to self-knowledge. It is a tool to get a job as well as an experience that should be positive and engaging, given the many years that people spend on it. A game-based experience is motivating since it is fun. Nowadays, educators use games as a daily practice. While VR games arent the only source of engagement and fun in class, they could create a substantial difference. A lot of things could be accomplished in a virtual environment that will not be possible in real life. Moreover, it is memorable and contributes to ones ability to learn.

VR introduces a new approach to rewards. The assessment of academic achievements and the progress of student reports are used in education for centuries. Nonetheless, VR will transform the traditional incentives concept in the learning process. Success is acknowledged, with rewards for achievements. In general, failures are ignored. This is the contrast of much education, wherein success is neutral and failure is punished. This type of rewards engage the brain and keep the students looking for more. Also, emotional reward could not be ignored. It creates a huge impact on the desire of a student to learn. While there always is a risk of discouragement, let alone competition. Its not easy, there are challenges that could not be accomplished the first time and there is increasing complexity as well. Taking risks and trying other methods are good strategies. The rewards that students get for the challenges that VR provides are individual and collective. Players have to work together and benefit for various skills and specializations of the members of the team. Everyone on the team is vital.

Collaboration in VR classroom boosts social integration of learners. Students that struggle to be part of the class group were able to be accepted by their peers due to their technology skills. With the technology, shy learners will come out of their shells and the kids, lacking in confidence previously in their math abilities, became confident technology experts. Virtual reality is apt to students with various needs and styles of learning. Furthermore, it provides a lot of opportunities for peer teaching and group work. What is impossible in reality is possible in virtual reality. The pedagogies of game-based and constructivism learning shows that students learn best by doing or being. They shouldnt just read about history, but they should be historians as well. They shouldnt just study archaeology but should be archaeologists themselves. The capacity to introduce practical knowledge to a classroom without actually leaving the space makes educational experience invaluable. Instead of simply listening to lectures, kids could put words underneath a headset and get real experience but in a virtual wrapper.

RiteshMehta

TatvaSoft Australia Pty Ltd.

Ritesh Mehta works as a senior Technical Account Manager in a software development company named TatvaSoft Australia based in Melbourne. He specializes in Agile Scrum methodology, Marketing Ops (MRM) application development, SAAS & SOA application development, Offshore & Vendor team management. Also, he is knowledgeable and well-experienced in conducting business analysis, product development, team management and client relationship management.

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How will Virtual Reality revolutionize Education? - Customer Think

OC Fair’s GameFest gives players a dose of virtual reality – Los Angeles Times

Jonathan Edwards jumped and dodged as masked soldiers fired assault rifles at him.

Though it might have seemed to the 14-year-old from Costa Mesa that he was in a war zone, the soldiers, fortunately, werent real.

They were part of a virtual reality video game that Jonathan was playing at the iBuyPower GameFest on Saturday at the Orange County Fair.

The festival, billed as a digital carnival meant to introduce PC gaming to casual fans, is being held through Sunday at The Hangar at the fairgrounds in Costa Mesa.

One of the highlights is a virtual reality village presented by Oculus, the company known for the Oculus Rift, a VR headset that immerses users in whatever game theyre playing.

Dozens of people tried their hand at the headset Saturday morning. Some became so enveloped in the digital reality that they had to be led back into place by event workers after straying from the game screen with their headsets on, presumably trying to chase down an enemy alien or escape the pursuit of pirates.

Ramiro Martinez, 25, of Fontana said that when he dropped something in the game, it actually felt like an object had fallen from his grasp. Martinez said he plays a lot of PC games but had never tried virtual reality before.

Elaine Lin, 50, of Irvine said she likes old-school games like Super Mario Bros., but she found the headset to be interactive and immersive.

The event also offers several other attractions.

Spectators watched as gamers dueled in Counter-Strike: Global Offensive in a long row of computers.

Other tournaments are being held throughout the weekend. Some will be shown on a big screen above The Hangar stage.

Throughout the day Saturday, the screen showed the World Cup tournament of the popular game Overwatch. A viewing area was set up in front of the screen for visitors who wanted to watch.

In addition, a row of 75 computers and various gaming stations were set up for people to try their hand at Rocket League, Overwatch and other titles.

This is iBuyPowers first event during the fair, though it held a gaming tournament at The Hangar last year that brought out thousands of people over a few days, said Tyrone Wang, development manager for the Industry-based gaming PC company.

That led the fair and the company to partner for GameFest, he said.

The event is free between 11 a.m. and 7 p.m. with paid admission to the fair, which costs $14 for adults and $7 for children and senior citizens.

For tickets for access to the festival after 7 p.m., visit ibuypower.com/Site/Event/IBP-GameFest.

The fair will be open from 11 a.m. to midnight Sunday, the final day of its month-long run.

benjamin.brazil@latimes.com

Twitter:@benbrazilpilot

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OC Fair's GameFest gives players a dose of virtual reality - Los Angeles Times

Coldplay and Samsung team up on virtual reality livestream – The Star Online

Those who tune in live will be able to hear Coldplay's music and experience the show's pyrotechnics and laser lights as they happen. Pictured is Chris Martin of Coldplay performing during Super Bowl 50. AFP Relaxnews

Coldplay's show at Chicago's Soldier Field will be broacast live in virtual reality to fans in 50 countries provided they have a Samsung Gear VR headset and compatible phone.

The band's show, part of their A Head Full of Dreamstour, is scheduled for Aug 17 and will be available through the Samsung VR service starting at 8:30pm CST (9:30am Aug 18 in Malaysia).

Those who tune in live will be able to hear Coldplay's music and experience the show's pyrotechnics and laser lights as they happen. Following the show, a concert replay will be available via Samsung VR for a limited time.

Virtual reality has increasingly been used to bring an enhanced music experience to fans. During the 2016 MTV Europe Music Awards, an accompanying app allowed users everywhere to livestream a 360 virtual reality view of the show.

A newly launched concert film from English rock band Queen called VR The Championsoffers an immersive, 360 3D performance available for iPhone, Android and on most web browsers, and compatible with all VR viewing systems. AFP Relaxnews

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Coldplay and Samsung team up on virtual reality livestream - The Star Online

Alt-Right? No, the Far Right. – Patheos (blog)

Its all going off in the US, thats for sure. But something that has been bugging me, and many others, is the use of the term alt-right. This seems to be aterm to describe the rise of the right amongst social media and popular culture that we have seen over the last ten years or so. What this does, however, is lend an air of credibility to the views, people and outlets that is unwarranted.

The intro on Wikipediais perhaps worth posting here:

Thealt-right, oralternative right, is a loosely defined group ofpeoplewithfar-rightideologieswho rejectmainstream conservatismin favor ofwhite nationalism, principally in theUnited States, but also to a lesser degree inCanadaandEurope.[1][2][3][4]Paul Gottfriedis the first person to use the term alternative right, when referring specifically to developments within American right-wing politics, in 2008.[5]The term has since gained wide currency with the rise of the so-called alt-right.White supremacist[6]Richard Spencercoined the term in 2010 in reference to a movement centered onwhite nationalism, and has been accused by some media publications of doing so to excuse overtracism,white supremacism, andneo-Nazism.[1][7]The term drew considerable media attention and controversy during and after the2016 US presidential election.[8]

Alt-rightbeliefshave been described asisolationist,protectionist,antisemitic, and white supremacist,[9][10][11]frequently overlapping withNeo-Nazism,[12][13][14]nativismandIslamophobia,[15][16][17][18][19]antifeminismandhomophobia,[12][20][21][22]right-wing populism,[23][24]and theneoreactionary movement.[9][25]The concept has further been associated with multiple groups fromAmerican nationalists, neo-monarchists,mens rights advocates, and the2016 presidential campaignofDonald Trump.[15][24][25][26][27]

The alt-right has its roots onInternetwebsitessuch as4chanand8chan, where anonymous members create and useInternet memesto express their ideologies.[9][14][28]It is difficult to tell how much of what people write in these venues is serious and how much is intended to provoke outrage.[23][29]Members of the alt-right use websites likeAlternative Right,Twitter,Breitbart, andRedditto convey their message.[30][31]Alt-right postings generally support Donald Trump[32][33][34][35]and opposeimmigration,multiculturalismandpolitical correctness.[13][20][36]

The alt-right has also had a significant influence on conservative thought in the United States, such as theSailer Strategyfor winning political support, along with having close ties to theTrump Administration. It has been listed as a key reason for Trumps win in the 2016 election.[37][38]The Trump administration includes several figures who are associated with the alt-right, such as White House Chief StrategistSteve Bannon.[39]In 2016, Bannon described Breitbart as the platform for the alt-right, with the goal of promoting the ideology.[40]

This reminds me of how UKIP ended up coming to prominence its a sort of evolution of ideas. I wrote about this back in 2014:

And what happened was this. UKIP busted the political landscape apart. They stole votes off most everyone and they went from zero to, well, hero in one night.

But how can a party which is effectively predicated upon fear of the foreigner and thinly, so very thinly, veiled racism become so successful in such a short time? This is my theory.

Firstly, there is the power of themere exposure effect. This is the fundamental concept of advertising whereby the brain finds things acceptable or even desirable through merely being exposed to the ideas. The more exposed, the more acceptable. UKIP have had a tremendous amount of airtime, with leader Nigel Farage doing the rounds on panel shows, radio shows and many news items. This is how creationism has prevailed, using the Wedge Strategy to get a foot in the door, get airtime, social media time, oxygen. That oxygen facilitates acceptability and then desirability. That was one of the arguments against having Bill Nye argue against Ken Ham about creationism.

Secondly, their success comes down to the evolution of ideas. Memetics is the theory that ideas are analagous to the evolution of biological organisms, with success of the organism surviving in its environment most successfully when it adapts characteristics to its environment. This survivability works just as well with ideas. Ideas which prevail have survival mechanisms and adapt to their environments. Think Christianity here. It has thoroughly evolved over 2000 years to adapt to society, morality, technology and economics. Islam, on the other hand, has developed the characteristic of threatening apostates with death. That works well, too.

Well, the history of the far right in Britain has gone from the National Front through to being reinvented into the British National Party (BNP) through to another reinvention (though the BNP still exist) in the form of UKIP (UKIPers might not like that realisation). What was going on in the early days of the right-wing extremist movement was that the ideas were not adapting well enough to the environments; they were too distasteful. The right-wing extremist ideology was just too much in the National Front to gather any traction with the general public. Then the BNP came along, and tried to be more respectable and appeal more widely. Some might say it was a slightly more (!) chilled version of the NF, appealing to more of the wider population. Ideas adapting. But still not becoming successful or acceptable enough.

And then UKIP, with its pseudo-political approach of getting out of Europe, has finally nailed it. Its just acceptable enough for people to not be afraid of saying in public, Yeah, I voted UKIP. I think we need to get out of Europe as a way of saying, Yeah, Polish, Romanian and those sodding Muslims can do one!

Now I didnt want to caricatureallUKIP voters in this way, but I stand by the idea that UKIP became the acceptable face of racism and xenophobia, playing into peoples fears.

In the same way, in the US, media outlets like Breitbart, TheBlaze, Circa, The Daily Caller and any other number of outlets are presenting themselves as fertile ground out of which confidence and brazen admitting of nefarious view can bear fruit. It is little surprise, then, that after years of allowing such outletsfree reign to spread their hate, the hate manifests itself in real ways. Thats the regrettable corollary of freedom of speech.

The terrible sights of Charlottesville over the last few days show that the old school far right has not died off, but has been simmering, and some have renamed it the alt-right. This merely disguises the ugly reality of the traditional far right and dresses it up in an air of acceptability and modern credibility.

This is unwarranted.

Dont be fooled by new-fangled terminology. The is the far right, and so many of these outlets peddle such extremist views.

I am disheartened by the sheer scope and spread of such views and how they have been able to gain footholds in modern popular culture. The internet is great, but it also houses torrents of distaste and hate.

Alt-right? Nah. Its still the far right, the dangerous extreme. Lets not give it more oxygen than it deserves.

Continued here:

Alt-Right? No, the Far Right. - Patheos (blog)

Majority of VA hospitals offer holistic therapies, alternative to opioids … – Washington Times

Nearly 80 percent of military medical facilities are offering alternative medicines for pain management and psychological treatment instead of opioids when possible, according to a study published Thursday by the nonprofit RAND Corp.

Over 8.9 million veterans are treated at 1,233 veteran health facilities each year, according to the Department of Veteran Affairs.

The study said there were about 76,000 alternative therapy patient visits per month treated by 1,750 providers. Services include acupuncture, yoga, relaxation therapy, among others, and responding physicians said patients often express interest and openness to the treatments.

Patient visits for [complementary and alternative medicine] make up a small but nontrivial portion of total outpatient [military treatment facilities] visits, the authors wrote.

However, physicians responded that a lack of providers and awareness of these services are barriers to providing care.

The most common conditions these therapies are used for according to physician responses include chronic pain, stress, anxiety, back pain and sleep disturbance.

Larger VA facilities and the U.S. Army offer the widest range of services, which additionally include chiropractic, stress management, progressive muscle relaxation, biofeedback and massage.

These treatments offer one more tool in the tool kit for dealing with issues like chronic pain, and they can offer an alternative to opioid drugs, Patricia Herman, the lead author of the study, said in a statement.

In addition, some of the mind/body practices can be effective for the reduction of post-traumatic stress disorder symptoms. A patient might not want to admit they have PTSD, but they may be persuaded to take a yoga class, she said.

The RAND Corp. study recommends that military health care facilities standardize codings for alternative medical practices, to better evaluate and understand their use and impact, and employ providers adequately credentialed and trained in these treatments.

More:

Majority of VA hospitals offer holistic therapies, alternative to opioids ... - Washington Times

FDA warns of contamination of multiple drugs, dietary supplements – The Intelligencer

Liquid vitamins for infants and children are among several supplements and drugs that the U.S. Food and Drug Administration is advising consumers and health care professionals not to use due to risk of severe infection.

The FDA is advising against using any liquid drug or dietary supplement products manufactured by PharmaTech LLC of Davie, Florida, and labeled by Rugby Laboratories, Major Pharmaceuticals and Leader Brands, due to potential contamination with the bacteria Burkholderia cepacia (B. cepacia) and the risk for severe patient infection.

The drug and dietary supplement products made by PharmaTech include liquid docusate sodium drugs (stool softeners), as well as various dietary supplements including liquid vitamin D drops and liquid multivitamins marketed for infants and children.A lab test done by the Centers for Disease Control and Prevention (CDC) found a strain of B. cepacia in samples of the stool softeners.

B. cepacia poses a serious threat to vulnerable patients, including infants and young children who still have developing immune systems, said FDA Commissioner Dr. Scott Gottlieb. These products were distributed nationwide to retailers, health care facilities, pharmacies and sold online making it important that parents, patients and health care providers be made aware of the potential risk and immediately stop using these products.

According to the CDC, B. cepacia poses the greatest threat to hospitalized patients, critically ill patients and people with health problems such as weakened immune systems and chronic lung diseases. The symptoms of B. cepacia infections vary widely from none at all to serious respiratory infections. It can spread from person-to-person by direct contact and is often resistant to common antibiotics.

Consumers, pharmacies and health care facilities should immediately stop using and dispensing all liquid drug and dietary supplement products manufactured by PharmaTech and labeled by Rugby Laboratories, Major Pharmaceuticals and Leader Brands.

This is not the first time the FDA has advised patients against using liquid docusate (stool softening) drug products manufactured at PharmaTech's Davie, Florida, facility. The FDA issued an advisory in 2016 after the products were implicated in the CDC's public health investigation into a multistate outbreak of B. cepacia infections.

The FDA encourages health care professionals and consumers to report adverse events or quality problems experienced with the use of drugs and dietary supplements products to the FDAs MedWatch Adverse Event Reporting program:

Read more from the original source:

FDA warns of contamination of multiple drugs, dietary supplements - The Intelligencer

Keeping fit: Overcome aging with strength training – The Daily Citizen

The aging process can be slowed -- or even reversed. But you must develop a concern for strength and muscle. If health, vitality and a long life free from serious disability are what you want you must consider what I'm about to say.

The most common disease of aging

The most prevalent condition to occur with age is sarcopenia, or what is better known as frailty. Sarcopenia is the medical term for "muscle weakening" or "body thinning." It is basically the muscle equivalent of osteopenia (bone thinning), or osteoporosis. Unfortunately, this condition has received little attention, even though its prevention is at the very heart of living a functional, independent life into older age.

The danger of neglect and inactivity

Even a young person, if you confine him to bed or a chair, will biologically age in fitness by almost two decades in just 21 days. This was actually demonstrated in the 1960s by Swedish physiologist Bengt Saltin. Since older people's bodies are already predisposed to losing muscle tissue and strength ("Use it or lose it," remember?), if we put them in a bed or easy chair for 21 days we can cripple them for the rest of their lives.

The real fountain of youth

Life extension and anti-aging have been pursued with increasing interest during the last three decades, so you can imagine my surprise when one of the only documented research studies showing reversal of aging at the cellular, genetic level in humans went largely ignored. In 2007, researchers published work revealing that a very basic weight training program practiced just twice a week improved strength, and actually reversed aging in 179 genetic markers at the cellular level.

These people's bodies were beginning to operate on a level that was many years their junior. A person who is 70 years old can weight train and more than double their strength over time -- easily outdoing a sedentary person two or more decades their junior. Or they can be sedentary and lose muscle and strength to the level of a 90-year-old. Your chronological age has little to do actually with how old you feel, or how old you are biologically. It is much more important to think in terms of healthy function and strength, and that is subject to 50-100 percent improvement or more with training.

The power of strength training

The good news is we have not found an age where the ravages of sarcopenia can't be reversed in a willing participant who can move themselves and maybe need only moderate assistance. In 1990, a study was done with nursing home residents in their 90s (each possessing at least two chronic diseases apiece). The researchers wanted to know if the residents' frailty and low muscle strength could be aided even at their advanced age. Working with the leg extension machine three times a week, these residents showed over a 150 percent increase in strength in just eight weeks. For a few this meant being able to stand unassisted, or walk without a cane. The potential was there all along but had been allowed to wane by neglect.

Don't allow your potential to wane with age.

Thomas Morrison is a fitness coordinator at Bradley Wellness Center.

Excerpt from:

Keeping fit: Overcome aging with strength training - The Daily Citizen

Time to pop an anti-ageing pill – Cosmos

"I need to last longer, the professor tells me. He lets my quizzical look hang for a moment, then quickly explains. Im on my second marriage and my wife is expecting twins.

Soon to be 50, the respected head of an Australian medical institute is contemplating the latest offering from the anti-ageing industry. Its a product that tops up the levels of nicotinamide adenine dinucleotide (NAD+), a commonplace chemical made by our bodies that is crucial for our metabolism.

Hes not alone. Leonard Guarente, a professor at Massachusetts Institute of Technology, has been taking NAD+ boosters for years; and in 2015 started a company, Elysium, to market them. There are likely thousands of users by now. Even NASA has been seduced. It hopes to use NAD+ to repair the DNA of astronauts bombarded by cosmic rays during the yearlong tip to Mars. DNA damage is one of the factors linked to ageing.

Something has changed in the anti-ageing field. Eccentrics and gullible-types have always availed themselves of anti-ageing remedies. Dubious supplements from gingko to hormones feed a mushrooming $30 billion industry. But when evidence-clamouring scientists start popping a pill, you sit up and take notice. Like the soon-to-be-50 Australian professor, most arent aiming to extend their lifespan; they are aiming to extend their health span the period of time before the diseases of ageing catch up with them: heart disease, arthritis, cancers, kidney disease and dementia.

This seal of approval from scientifically literate customers reflects a revolution in the science of ageing. Thirty years ago, there was none. Most scientific thinking held that ageing was not amenable to tweaking. No more than preventing wear and tear on your car. Yet animals do age at different rates a lab rat lives for three years, but a mole rat for 40. Rather than a random process of degradation, this surely suggests some underlying program, one that might be hacked.

In the late 1980s, scientists proved that was indeed the case at least in yeast and roundworms. They tinkered with the genes of these creatures and extended their lifespans and healthspans. In the case of roundworms, lifespan could be doubled by altering a single gene!

Suddenly science had some levers to push and in a compelling demonstration of how the fundamentals are conserved through evolution, the same genetic levers were identified in mice and humans. But altering the genes of humans is not on the cards. So for more than a decade now, researchers have searched for drugs to tweak those same genes.

NAD+ boosters have now become the party favourite. In part because theyre not drugs; they are natural products that restore body chemistry to a more youthful state. By age 50, NAD+ levels are half what they were at 20. Top up NAD+ levels in elderly mice and their muscles becomes like those of youngsters, their stem cells get more oomph and they live longer.

So have scientists finally found the fountain of youth? And if its good enough for scientists, should the rest of start taking NAD+ supplements?

I feel a bit like the character Morpheus in the movie The Matrix, in the scene where he offers Neo either the blue pill or the red pill: You take the blue pill the story ends, you wake up in your bed and believe whatever you want to believe. You take the red pill and I show you how deep the rabbit hole goes.

I had a similar experience researching this story. Some researchers I interviewed were in the blue-pill camp: they felt that we probably know enough about ageing to intervene. Others were red-pill types. The rabbit hole was too deep, they didnt think we knew enough to start intervening.

So Ill give you the Morpheus choice here.

The reason some serious scientists are taking NAD+ supplements is because of a series of epiphanies, which have erected a glittering scientific edifice on what just three decades ago was just a swampy backwater.

Just about every university now has a department for ageing research; and its not just academic institutes. Google entered this space in 2015 with its secretive subsidiary Calico, which is bringing big data to bear on the problem. Craig Venter, who pioneered the reading of the human genome, started the company Human Longevity to decode the genes for long life.

Less is more: restricting calorie intake has been shown to increase lifespan in every species studied.

Cosmos Magazine

California-based Alkahest is mining the regenerative factors in youthful blood, and there are plenty more variations on theme from start-ups such as Progenics and Unity.

But roll back 30 years and studying ageing was career suicide for any serious scientist. Meanwhile at the other end of the biological spectrum, the science of embryo development was booming. Just how the mush of an egg turned into an embryo had long been biologys greatest mystery. By the late 1980s, researchers had uncovered a genetic program that ran the process in everything from roundworms to human beings. These lessons from embryos would help propel the study of ageing into the mainstream.

Lesson number one was that the fundamentals of biology are preserved across the species. In the late 1980s Cynthia Kenyon was compelled by this lesson. She was a 30-something slim blonde, possessed of exceptionally youthful features and an infectious enthusiasm for science. Her model organism was the one-millimetre-long, 959-cell-strong roundworm, Caenorhabditis elegans. Kenyon was struck by its very obvious ageing. In two weeks it went from agile slitherer to a decrepit creature barely able to drag itself across the culture dish.

She felt sorry for the worms. She was also intrigued. Perhaps, like development, ageing was also a process under some sort of control. She set out to see if tweaking genes, by bombarding the worms with mutagenic chemicals, might affect their lifespan. Her hunch was rewarded by a remarkable mutant. At four weeks of age it was still slithering like a teenager. Tweaking a single gene more than doubled its lifespan.

In 1993 Kenyon published a paper in Nature revealing the identity of that gene as daf-2, which may not mean all that much to you; but there was a revelation lurking behind the name.

One of the big lessons of the 1980s was that genes dont change all that much during evolution. They acquire some code changes and get repurposed, but its still possible to recognise them. Sort of like the way words change in language you can still pick out the ancient Greek roots.

So it wasnt surprising that mammals turned out to have two genes that resembled daf-2. The surprise lay with their job description. In humans, the counterparts of the worms life-extension gene are the insulin receptor gene and its close relative, the insulin-like growth factor 1 receptor gene (IGF1R).

To understand why this was such a revelation, you need to know a couple of things.

Insulins job is to mobilise the body to respond to food intake. Like a warehouse overseer receiving a stock delivery, the hormone is released into the blood to ensure many systems are quickly mobilised. The insulin receptor conveys these signals to the body tissues so nutrients are used as needed or stored as fat.

Roundworms showed that signals about food availability also had a link to ageing. But even before the worm discovery we knew that.

Back in the Great Depression of the 1930s, many people went hungry. Wondering about the effect on growth and long-term health, Cornell University nutritionist Clive McKay set up rat experiments to mimic calorie restriction. To his surprise the rats, so long as they received adequate nutrients, actually lived longer. The experiment has been repeated in yeast, worms, flies, mice and primates.

The rough rule of thumb is: restrict calorie intake by 30% and see up to a 30% increase in lifespan. The effects are smaller in mice and even smaller in primates. Not many people have the willpower to adhere to a lifelong diet, though occasional fasting mimicking diets developed by Walter Longo at the University of Southern California seem to have beneficial effects. Nevertheless the holy grail has been to find a drug that could mimic fasting.

Kenyons identification of the daf-2 gene provided an entry point into the circuit linking food intake with life extension. In the following years, she and others teased out more key components. Research showed the same components played a role in the ageing of different species. Long-lived dogs and long-lived people showed evidence of tweaks to their IGF1-R gene. Another genetic tweak that doubled a worms lifespan, daf-16, turned up in long-lived men. They were more likely to carry a particular variation in a gene called FOX0-3A, which harboured within it the recognisable code of daf-16.

Another entry point into the ageing circuitry came from the yeast Saccaromyces cerevisiae. It might seem absurd to go looking for the secrets of ageing in a single-celled yeast, but this cell resembles one of our own in that it has multiple chromosomes housed in a nucleus. Remarkably the yeast also possesses many recognisable features of ageing. A single yeast cell will eventually age and die after a couple of days. If coaxed to bud off daughters, it will undergo a kind of menopause; spawning so many daughter cells and no more. It also demonstrates the universal feature of ageing: deprive yeast of calories and it lives longer.

Just as with roundworms, the search for mutants delivered. In 2000, Leonard Guarentes lab at MIT found yeast mutants that continued to spawn for about about 30% longer than normal. The gene responsible was named Sirtuin 2 (Sir 2). It was a completely different component of the ageing circuit to anything unearthed in the worm. It made parts of the DNA code inaccessible or silent the prefix Sir stands for silent information regulator.

Sirtuins work by increasing the stickiness of the histone proteins that wrap up DNA. Worms, flies, mice and humans all have them and experiments with worms, flies and mice indicates that increasing sirtuin activity modestly extends lifespan.

Yeast studies also delivered another windfall. Like other organisms, yeast lifespan increases when calories are restricted. As yeast doesnt have insulin or IGF1 receptors, some other genetic components must be responsible for sensing calories. In 2005 researchers found that role was played by a curious gene known as the target of rapamycin or TOR (in mammals the gene is called mTOR). When the TOR gene senses low levels of calories, it responds by slowing down protein synthesis. It also stimulates recycling of a cells components, a process known as autophagy.

It seemed to make sense. Calorie restriction flips a metabolic switch from abundance to austerity. Like when you get a big salary cut, you dont go adding extensions to the house; you hunker down, live modestly, recycle your old things and delay your plans to have babies. Somehow responding to this stress also lengthens lifespan.

These days researchers think autophagy plays a big part in the lengthening. For instance, Walter Longos recent studies on mice and humans shows that fasting accelerates the refurbishing of tissues, clearing away damaged senescent cells while turning on renewing stem cells.

The name target of rapamycin is an accident of history. Rapamycin was discovered in a bacterium that grows in the soils of Rapa Nui, better known as Easter Island. Rapamycins ability to flip the TOR lever makes it a drug with profound effects. Until now, its major medical use has been to stop the rejection of foreign tissues in transplant patients by toning down their immune systems. But it was destined for greater things.

Enter Sydney-born David Sinclair. He had long been compelled by the lessons of ageing learnt from yeast. In 1997at Lenny Guarentes lab he had found a mutant yeast that aged faster. The faulty gene, SGS1, was related to one causing Werner syndrome. Just like yeast, affected people age faster. But it was yeasts Sir 2 gene that captivated him. It appeared to be a lever that flipped during calorie restriction. Perhaps chemicals could do the same thing. In 2003 he hit pay dirt with a plant-derived compound called resveratrol. To everyones delight, it was found in red wine though youd have to imbibe litres to get an active dose. Soon after, he spun off the company Sirtris to commercialise compounds like resveratrol; it was bought by GlaxoSmithKline in 2008.

Sinclair, who now heads labs both at the University of NSW and Harvard Medical School, says GSK has a whole stable of sirtuin-activating compounds in testing, some of which are 1,000 times stronger than resveratrol.

His attention, in any event, has shifted to NAD+. The chemical had been hiding in plain sight since 2000, when sirtuins were identified as an anti-ageing lever in yeast. It was clear NAD+ acted like a grease for the sirtuin mechanism. Since its discovery some 100 years earlier as a yeast co-factor that stimulated fermentation, NAD+ had been found to grease a multitude of metabolic reactions but few thought of it offered a potential treatment. It was, as Sinclair put it, the most boring molecule in biochemistry. How could raising the levels of such a commonplace substance have any effect?

Furthermore, it was also not clear how to raise its levels: NAD+ itself is very unstable, and cant actually get inside cells where it is needed.

Two things changed the game. One was that researchers discovered NAD+ levels decline with age but are raised by calorie restriction and exercise. The other was identifying several natural precursors of NAD+ nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) that were much more stable, could enter cells and raised NAD+ levels when given to animals.

Johan Auwerxs laboratory at the Swiss Federal Institute of Technology in Lausanne showed in 2016 that NR boosted the multiplication of skin, brain and muscle stem cells, and slightly increased the longevity of mice, even when given in middle age.

Sinclairs lab showed in 2013 that mice treated with NMN boosters had improved muscle strength, and earlier this year that mice treated with NMN had superior ability to repair their DNA the reason NASA is now engaged in talks with Sinclairs lab.

Which brings us back to NAD+ boosters. The excitement is that NAD+ boosters are not drugs. So you neednt wait; there are companies willing to oblige by providing NR supplements, such as Guarentes startup, Elysium. It has some cred no less than five Nobel prize winners on its advisory board. In lieu of a trial, Guarente says the company will follow up results with clients over time. There are concerns as to whether NAD+ levels are truly raised by the supplement but, for what its worth, have a google and youll find anecdotal testimonials from people saying they feel peppier for taking it.

So what do you do? Just because something is a natural compound doesnt guarantee that boosting its levels in middle age is a safe thing to do. As Sinclair reported at a recent conference in Sydney, NMN not only helped aged mice develop stronger muscles but also triggered the growth of tiny blood vessels. That might flag a risk, since cancer cells rely on newly formed blood vessels to spread.

On the other hand, its pretty clear what the effects of ageing are a dramatically increased likelihood of developing all sorts of diseases.

Depends if youre the punting type.

ELSEVIER INC

You might think with all the epiphanies of the past 30 years, surely we know enough about ageing to go full speed ahead with interventions? All the candidate compounds, so far, seem to hack into the same pathway triggered by calorie restriction.

Well, yes but this rabbit hole goes very deep. Take calorie restriction, the supposedly iron-clad way to trigger lifespan extension. In fact, studies in mice show very different effects, depending on their breed, gender and even what they are fed. Rafael da Cabo, who runs the long-term calorie restriction study on rhesus monkeys at the US National Institute of Ageing, told me some breeds of mice actually live shorter lifespans when calorie-restricted; and females may respond better than males or vice versa. Nor is it just about calories: sorry paleo dieters but high-protein diets shorten lifespan in mice. So go figure where you as an individual, endowed with a specific gender and a unique set of genes, fit into all this.

Over the years, one compelling theory has been that it controls the integrity of mitochondria, the engines of our cells which clearly degenerate as we age. According to the theory, the corrosive by-products of cellular combustion free radicals cause ongoing damage as an inevitable consequence of being alive. But numerous recent experiments show that slowing the generation of free radicals in mice or flies, doesnt actually slow the ageing process. In fact, it seems to have the opposite effect. Nowadays the paradigm shift is that stress signals like those from free radicals, fasting or exercise trigger an adaptive anti-ageing response.

It doesnt mean past theories are entirely wrong. As da Cabo says: Nothing has been disproven. Its just that there is a lot of other stuff going on in ageing as well. At least nine targets appear to be controlled by the ageing circuitry, ranging from the fraying of telomeres on the tips of chromosome to epigenetic disturbances that change how the DNA code is read.

Kenyons epiphanies with worms suggested for a while that tweaking the controls for ageing might be simple. Indeed these days its possible to extend the lifespan of worms ten-fold. But mammals are complex. Da Cabo offers the metaphor of a Model T Ford compared to a modern Tesla. Back in the 1920s you could tune the engine with a few tweaks from a spanner. Good luck trying that with a Tesla!

Luckily, just like todays car mechanics, researchers now have mind-boggling tools to deal with mindboggling complexity they can monitor the activity of every gene and the output of metabolism with socalled omics technologies and leave it to machinelearning algorithms to figure out whats going on. This is the sort of big data approach that Googles subsidiary Calico is applying to the biology of ageing.

The companys chief scientific officer: Cynthia Kenyon. None of this means the era of anti-ageing medicine has to wait for us to explore every blind alley of the rabbit hole. Indeed, most of the researchers I spoke with passionately believe they are more than ready to start testing the plethora of promising new compounds in their pipelines.

Whats needed is the faucet at the end the regulatory framework that will incorporate ageing as a medical indication. So that people who need to last longer dont have to be punters.

This article appeared in Cosmos 75 - Winter 2017 under the headline "Time to pop an anti-ageing pill"

Read the original post:

Time to pop an anti-ageing pill - Cosmos