Society’s Dependence on the Internet: 5 Cyber Issues the Coronavirus Lays Bare – Nextgov

As more and more U.S. schools and businesses shutter their doors, the rapidly evolving coronavirus pandemic is helping to expose societys dependencegood and badon the digital world.

Entire swaths of society, including classes we teach at American University, have moved online until the coast is clear. As vast segments of society are temporarily forced into isolation to achieve social distancing, the internet is their window into the world. Online social events like virtual happy hours foster a sense of connectedness amid social distancing. While the online world is often portrayed as a societal ill, this pandemic is a reminder of how much the digital world has to offer.

The pandemic also lays bare the many vulnerabilities created by societys dependence on the internet. These include the dangerous consequences of censorship, the constantly morphing spread of disinformation, supply chain vulnerabilities and the risks of weak cybersecurity.

1. Chinas censorship affects us all.

The global pandemic reminds us that even local censorship can have global ramifications. Chinas early suppression of coronavirus information likely contributed to what is now a worldwide pandemic. Had the doctor in Wuhan who spotted the outbreak been able to speak freely, public health authorities might have been able to do more to contain it early.

China is not alone. Much of the world lives in countries that impose controls on what can and cannot be said about their governments online. Such censorship is not just a free speech issue, but a public health issue as well. Technologies that circumvent censorship are increasingly a matter of life and death.

2. Disinformation online isnt just speechits also a matter of health and safety.

During a public health emergency, sharing accurate information rapidly is critical. Social media can be an effective tool for doing just that. But its also a source of disinformation and manipulation in ways that can threaten global health and personal safety something tech companies are desperately, yet imperfectly, trying to combat.

Facebook, for example, has banned ads selling face masks or promising false preventions or cures, while giving the World Health Organization unlimited ad space. Twitter is placing links to the Centers for Disease Control and Prevention and other reliable information sources atop search returns. Meanwhile, Russia and others reportedly are spreading rumors about the coronaviruss origins. Others are using the coronavirus to spread racist vitriol, in ways that put individuals at risk.

Not only does COVID-19 warn us of the costs and geopolitics of disinformation, it highlights the roles and responsibilities of the private sector in confronting these risks. Figuring out how to do so effectively, without suppressing legitimate critics, is one of the greatest challenges for the next decade.

3. Cyber resiliency and security matter more than ever.

Our university has moved our work online. We are holding meetings by video chat and conducting virtual courses. While many dont have this luxury, including those on the front lines of health and public safety or newly unemployed, thousands of other universities, businesses and other institutions also moved online a testament to the benefits of technological innovation.

At the same time, these moves remind us of the importance of strong encryption, reliable networks and effective cyber defenses. Today network outages are not just about losing access to Netflix but about losing livelihoods. Cyber insecurity is also a threat to public health, such as when ransomware attacks disrupt entire medical facilities.

4. Smart technologies as a lifeline.

The virus also exposes the promise and risks of the internet of things, the globe-spanning web of always-on, always-connected cameras, thermostats, alarm systems and other physical objects. Smart thermometers, blood pressure monitors and other medical devices are increasingly connected to the web. This makes it easier for people with pre-existing conditions to manage their health at home, rather than having to seek treatment in a medical facility where they are at much greater risk of exposure to the disease.

Yet this reliance on the internet of things carries risks. Insecure smart devices can be co-opted to disrupt democracy and society, such as when the Mirai botnet hijacked home appliances to disrupt critical news and information sites in the fall of 2016. When digitally interconnected devices are attacked, their benefits suddenly disappear adding to the sense of crisis and sending those dependent on connected home diagnostic tools into already overcrowded hospitals.

5. Tech supply chain is a point of vulnerability.

The shutdown of Chinese factories in the wake of the pandemic interrupted the supply of critical parts to many industries, including the U.S. tech sector. Even Apple had to temporarily halt production of the iPhone. Had China not begun to recover, the toll on the global economy could have been even greater than it is now.

This interdependence of our supply chain is neither new nor tech-specific. Manufacturing medical and otherwise has long depended on parts from all over the world. The crisis serves as a reminder of the global, complex interactions of the many companies that produce gadgets, phones, computers and many other products on which the economy and society as a whole depend. Even if the virus had never traveled outside of China, the effects would have reverberated highlighting ways in which even local crises have global ramifications.

Cyber Policy in Everything

As the next phase of the pandemic response unfolds, society will be grappling with more and more difficult questions. Among the many challenges are complex choices about how to curb the spread of the disease while preserving core freedoms. How much tracking and surveillance are people willing to accept as a means of protecting public health?

As Laura explains in The Internet in Everything, cyber policy is now entangled with everything, including health, the environment and consumer safety. Choices that we make now, about cybersecurity, speech online, encryption policies and product design will have dramatic ramifications for health, security and basic human flourishing.

Laura DeNardis is a professor of communication studies at American University School of Communication and Jennifer Daskal is a professor of law and faculty director of the Technology, Law & Security Program at American University.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Society's Dependence on the Internet: 5 Cyber Issues the Coronavirus Lays Bare - Nextgov

Indias government wants to censor the media to fight Covid-19 but transparency is a better weapon – Scroll.in

On Tuesday, it emerged that the Indian government had asked the Supreme Court to legalise censorship. Claiming that there is a high chance of panicked reactions based on any deliberate or unintended fake or inaccurate reporting, it urged the court to issue orders that would not allow any news to be published or broadcast without media organisations first ascertaining the true factual position meaning whatever the government says.

The Supreme Court ultimately chose not to institute a system of censorship, but accepted the governments dubious claim that the mass exodus of migrant workers over the last week was due to fake news. We do not intend to interfere with the free discussion about the pandemic, but direct the media refer to and publish the official version about the developments, the court said in its verdict.

The problem with these contentions is that they miss the actual reason for panic in the country over the last two weeks.

First there was a wave of panic buying in Indias markets even before Prime Minister Narendra Modi announced a self-imposed janata curfew, simply because of his reputation for political unpredictability.

There was even more panic buying after Modis second speech, because he did not clearly explain to people how they could get food and medicines during the three-week shutdown, prompting the prime minister to tweet in all caps, THERE IS NO NEED TO PANIC.

Finally, the migrant labour exodus began as soon as it became clear that lockdowns were being considered and that work and wages would dry up. In Delhi, as the Bharatiya Janata Party sought to wriggle out of responsibility for the masses of workers heading out of the city, it floated the theory that the flight had been caused by the actions of the Aam Aadmi Party government. It did not identify the media as the villain.

It is clear thaat the panic and rumours have come about not because of the media but because of the lack of information from the government. The courts directions to the media that it must take the official version are a problem because, in many cases, the government has simply not been forthcoming.

The government has made it difficult to access most information whether it is data on the number of people who have been confirmed with Covid-19, how much testing India is doing, whether the government has sufficient stockpiles of safety equipment, what the spread of the disease looks like, why there were major delays in sourcing of gear for healthcare workers, the technical specifications for testing kits approved for use in India, and much more.

In many cases, it was only after repeated questioning that the government issued the information at all. In fact, there has been so much stone-walling that a collective of health reporters across various news organisations decided to publish this list of 10 questions that the government needs to answer.

This lack of transparency is short-sighted. By refusing to give information, or not creating the systems for easy dissemination, the government may believe it can better control the narrative. But diseases cannot be beaten by winning the narrative.

Here are three reasons why the government should be much more transparent.

In this age of social media and a 24-hour news cycle, a limited amount of information from the government will only lead to more speculation about the situation. The best way to combat this is by providing precise, detailed information and to disseminate it widely.

There is undoubtedly fake news going around but the best way to defeat it would be for the government to answer all the questions that journalists pose and ensure that any citizen can easily access information. Hiding data, delaying numbers and refusing to answer questions does not inspire any confidence. It will only inspire more rumours.

For India to effectively battle the pandemic, officials from the local level up to the Central as well as many in the private sector must be focused on taking on Covid-19 right now. Yet the government has not even been transparent about which testing kits for the coronavirus have been approved for use by private companies and state governments.

This may just have been an oversight. But it is only when the media is free to ask questions that the governments attention will be drawn to such crucial gaps in information that could have a direct bearing on how successful India is in its fight against Covid-19.

This is not just about looking bad under media questioning. This is about having all the information to address the Coronavirus crisis.

No one criticises the government for not already having a vaccine to prevent the spread of the new coronavirus. Why? Because people understand that this is a new phenomenon that has precipitated a global crisis and will take all the best efforts of governments and individuals all over the world to combat.

Indeed, we need to look far beyond the capabilities of just the Indian state. The Principal Scientific Adviser to the government of India has called on the countryslarge pool of scientists and companies working in the field of science to help take on this challenge. The NITI Aayog has called for doctors to volunteer to tackle the outbreak. Many in Indias Information Technology sector organsed a hackathon to develop apps that can assist in the battle.

Indeed, much of the worlds responses to Covid-19 have been aided by involvement of private individuals, whether researchers or coders or medical professionals.

But for government to enlist the public in this battle whether it is a medical scholar in a small town that needs to know which testing kits are approved or an I-T professional who needs more data about testing to design better analytics or a high-net-worth individual who wants to source and distribute protective equipment but doesnt know whether India is lacking them and which part of the country has insufficient stockpiles it will only be possible if authorities are forthcoming with information.

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Indias government wants to censor the media to fight Covid-19 but transparency is a better weapon - Scroll.in

YouTube continues to ban crypto content; None knows the reason – iNVEZZ

Apart from the devastating crash that Bitcoin is currently facing, another potential threat to the pioneer cryptocurrency and the entire crypto industry at large is censorship from giant tech companies like YouTube.

In a recent bout of censorship, two separate crypto YouTube channels had videos deleted temporarily.

The two YouTubers who had their videos deleted include Ivan on Tech (a crypto programmer) and The Moon (a crypto reporter and technical analyst).

Both responded to the matter via twitter saying that they had received several strikes from YouTube about Bitcoin being harmful content.

YouTube has a long history of censoring crypto content.

At the tail end of 2019, many crypto YouTubers including seasoned content creators like Nicholas Merten received content strikes from YouTube despite not uploading videos for days.

In a tweet, Merten said,

In response, The MoonCarl also replied in a tweet that acknowledged a similar move by YouTube on his channel.

Other channels like Nugget News received up to two content strikes in a single day with 50 videos being removed from the channel.

Saunders, the owner of Nugget News, expressed fears of the channel getting deleted from YouTube in a tweet that read,

Also affected was a Canadian Bitcoin educator with a channel called BTCSessions and Chriss Dunn a crypto and finance reporter.

Following the crypto purge of 2019 on YouTube, an outrage emerged on twitter to which YouTube replied saying that the decision to ban Bitcoin and cryptocurrency videos from its site was an error and the removed videos would be reinstated.

It might be argued that the move was meant to protect consumers from scams.

However, for most onlookers as well as the entire crypto community, the move does not make any sense especially since Google and Facebook already lifted the crypto advertising ban in 2018.

Invezz asked Mati Greenspan, the founder of Quantum Economics, about his opinion on whether the current bout of crypto censorship is as a result of the companys hidden agenda or the result of an internal error.

In his reply, Greenspan said that it is difficult to know for sure but many in the community feel that the censorship is international.

He adds,

We could only speculate on why they might want to censor crypto content, perhaps it threatens their current future business model in some way.

While speaking to Decrypt, a YouTube spokesman said,

With the massive volume of videos on our site, sometimes we make the wrong call.When its brought to our attention that a video has been removed mistakenly, we act quickly to reinstate it.

However, with recent reports indicating a continuation of the crypto ban on YouTube, the reasons for deletion crypto-related videos remains to be anyones guess.

While YouTube hasnt responded to the recent bout of censorship and why its still affecting crypto-related channels, some on twitter have suggested moving crypto content to decentralized platforms that are censorship-resistant.

In reaction to last years crypto purge on YouTube, Greenspan together with several crypto YouTubers moved to boycott YouTube.

This time around, when asked whether there are any other viable decentralized alternatives for crypto YouTubers, Greenspan replied,

Im not sure there are any viable decentralized options at this point. For myself though, Ive preferred not to stream on YouTube for the time being and instead am hosting live streams on Periscope and Twitter.

Weighing in on the matter, Chris Burniske, a renowned crypto influencer, tweeted that such violations by companies like YouTube, will push suppliers and consumers away from platforms and towards protocols.

Burniske also added that since platforms like YouTube are owned by shareholders and give no governance rights to suppliers and consumers and further centralize economic resources over time, the violations crypto YouTubers are facing currently are bound to repeatedly occur.

Censorship on platforms like YouTube has existed for a long time. While there are many theories on twitter explaining the reasons for the latest censorship bout, it is clear to most like Burniske that this will not be the end of it. Platforms like YouTube face pressure from different governments, advertisers, and organizations to remove a wide range of content. Perhaps its time for the crypto community to create their decentralized alternatives much like how Everipedia is disrupting the Wikipedia formula without the use of advertisement.

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YouTube continues to ban crypto content; None knows the reason - iNVEZZ

How Authoritarians Are Exploiting the Covid-19 Crisis to Grab Power – The New York Review of Books

Isaac Lawrence/AFP via Getty ImagesPro-democracy activists holding pictures of missing citizen journalist Fang Bin and anti-corruption activistXu Zhiyong, who had been interrogating President Xi Jinpings handling of the Covid-19 crisis, at a protest outside the Chinese liaison office in Hong Kong, February 19, 2020

For authoritarian-minded leaders, the coronavirus crisis is offering a convenient pretext to silence critics and consolidate power. Censorship in China and elsewhere has fed the pandemic, helping to turn a potentially containable threat into a global calamity. The health crisis will inevitably subside, but autocratic governments dangerous expansion of power may be one of the pandemics most enduring legacies.

In times of crisis, peoples health depends at minimum on free access to timely, accurate information. The Chinese government illustrated the disastrous consequence of ignoring that reality. When doctors in Wuhan tried to sound the alarm in December about the new coronavirus, authorities silenced and reprimanded them. The failure to heed their warnings gave Covid-19 a devastating three-week head start. As millions of travelers left or passed through Wuhan, the virus spread across China and around the world.

Even now, the Chinese government is placing its political goals above public health. It claims that the coronavirus has been tamed but wont allow independent verification. It is expelling journalists from several leading US publications, including those that have produced incisive reporting, and has detained independent Chinese reporters who venture to Wuhan. Meanwhile, Beijing is pushing wild conspiracy theories about the origin of the virus, hoping to deflect attention from the tragic results of its early cover-up.

Others are following Chinas example. In Thailand, Cambodia, Venezuela, Bangladesh, and Turkey, governments are detaining journalists, opposition activists, healthcare workers, and anyone else who dares to criticize the official response to the coronavirus. Needless to say, ignorance-is-bliss is not an effective public health strategy.

When independent media is silenced, governments are able to promote self-serving propaganda rather than facts. Egypts President Abdel Fattah el-Sisi, for example, downplayed the coronavirus threat for weeks, apparently wanting to avoid harming Egypts tourist industry. His government expelled a Guardian correspondent and warned a New York Times journalist after their articles questioned government figures on the number of coronavirus cases.

The government of Turkeys President Recep Tayyip Erdogan implausibly denies that there are any Covid-19 cases in its prisons, and a prosecutor is investigating a member of parliamenthimself a doctorwho says that a seventy-year-old inmate and a member of the prison staff have tested positive. Thailands Prime Minister Gen Prayut Chan-ocha warned journalists to report on government press conferences only and not to interview medical personnel in the field.

Of course, a free media is not a certain antidote. Responsible government is also needed. US President Donald Trump initially called the coronavirus a hoax. Brazilian President Jair Bolsonaro called the virus a fantasy and preventive measures hysterical. Before belatedly telling people to stay home, Mexican President Andrs Manuel Lpez Obrador ostentatiously held rallies, and hugged, kissed, and shook hands with supporters. But at least a free media can highlight such irresponsibility; a silenced media allows it to proceed unchallenged.

Recognizing that the public is more willing to accept government power grabs in times of crisis, some leaders see the coronavirus as an opportunity not only to censor criticism but also to undermine checks and balances on their power. Much as the war on terrorism was used to justify certain long-lasting restrictions on civil liberties, so the fight against the coronavirus threatens longer-term damage to democratic rule.

Although Hungary has reported Covid-19 infections only in the hundreds to date, Prime Minister Viktor Orbn used his partys parliamentary majority to secure an indefinite state of emergency that enables him to rule by decree and imprison for up to five years any journalist who disseminates news that is deemed false. Philippines President Rodrigo Duterte has also awarded himself emergency powers to silence fake news.

As Israeli Prime Minister Benjamin Netanyahu faces corruption charges, his justice minister cited the coronavirus to suspend courts for most cases, as did a close parliamentary ally as he attempted to prevent the oppositions new majority from ousting him as Knesset speakera move that the Israeli Supreme Court said undermin[ed] the foundations of the democratic process. The Trump administration has cited the coronavirus to discourage requests under the Freedom of Information Act, suddenly insisting they be made by only traditional mail, in spite of the greater public health safety of electronic communication.

Some governments are breathing a sigh of relief that the coronavirus has provided a convenient reason to limit political demonstrations. The Algerian government has halted regular protests seeking genuine democratic reform that have been under way for more than a year. The Russian government has stopped even single-person protests against Vladimir Putins plans to rip up term limits on his presidency. The Indian governments recently announced three-week lockdown conveniently ends the running protests against Prime Minister Narendra Modis anti-Muslim citizenship policies. It remains to be seen whether such restrictions outlive the coronavirus threat.

Other governments are using the coronavirus to intensify digital surveillance. China has deepened and extended the surveillance state that is most developed in Xinjiang, where it was used to identify some of the one million Uighur and other Turkic Muslims for detention and forced indoctrination. South Korea has broadcast detailed and highly revealing information about peoples movements to anyone who might have had contact with them. Israels government has cited the coronavirus to authorize its Shin Bet internal security agency to use vast amounts of location-tracking data from the cellphones of ordinary Israelis. In Moscow, Russia is installing one of the worlds largest surveillance camera systems equipped with facial recognition technology. As occurred after September 11, 2001, it may be difficult to put the surveillance genie back in the bottle after the crisis fades.

There is no question these are extraordinary times. International human rights law permits restrictions on liberty in times of national emergency that are necessary and proportionate. But we should be very wary of leaders who exploit this crisis to serve their political ends. They are jeopardizing both democracy and our health.

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How Authoritarians Are Exploiting the Covid-19 Crisis to Grab Power - The New York Review of Books

Under the pretext of combating coronavirus States trying to crush the opposition and to tighten censorship – The KXAN 36 News

Police checks on the observance of quarantine measuresAzrbaycan Respublikas Daxili Nazirliyi Ilr / Twitter Turkish Police checks on the observance of quarantine measuresTrk Polis Tekilat / / Twitter

human rights activists around the world pay attention to the fact that some governments are trying to use combat coronavirus as a pretext to increase pressure on the opposition and uncontrolled media. Officials also tend to give extremely broad powers.

Examples of this policy, particularly in the post-Soviet space, leads to BBC Russian service. So, on March 19 the President of Azerbaijan Ilham Aliyev stated that the fifth column and national traitors can use the pandemic coronavirus to commit provocations. He accused the opposition of trying to sow confusion and panic. After that, the country has carried out arrests of opposition leaders.

In Armenia government ordered the media to publish information only from official sources. In the end, the Public television of Armenia was forced to remove an article which quoted the CNN report that Irans average every 10 minutes someone dies from itarenavirus.

the actions of the authorities of Armenia criticized the OSCE and the international organization reporters without borders. Shortly after this the Yerevan partially backed down. Authorities allowed to publish information on the topic of coronavirus, obtained from official international sources.

However, all restrictions applied only to publications related to the coronavirus. Materials on other topics are not censored.

In Belarus 152 cases of coronavirus, 1 died. Restrictions are not imposed and the authorities clearly underestimate the threat. But the proliferation of information on the coronavirus is in full swing.

a Week ago the countrys President Alexander Lukashenko ordered the KGB to deal with the sources of information that sow panic about the outbreak of coronavirus. Already enough to look at it. Should be a good go to these sites, channels. You need to understand the villains who throw these fakes. Why are people bullied? Lukashenka said.

the President also said that he sees no reason for postponing the elections of the heads of Belarus, scheduled for August 2020. The opposition has canceled a meeting with voters in the regions due to the threat of the spread of coronavirus.

In Turkey coronavirus has infected more than 10 thousand people, 168 died, in 18 provinces has been quarantined. More than 300 people were arrested for publishing in social networks related to the coronavirus.

was recently arrested driver of the truck that issued your account a video criticizing the actions of the authorities to contain the epidemic.

In Hungarian coronavirus were detected in 492 people, of whom 15 died. The country has a regime of emergency. The Prime Minister of Hungary Viktor Orban, referring to special circumstances in connection with pandasAMIA, on Monday held a law through Parliament, giving his government extraordinary powers for an indefinite period, during which the government will actually govern without Parliament, only informing the speaker and faction leaders about the measures taken.

the law, among other things, provides for the punishment for the spread of what the government considers misinformation about the pandemic from one year to five years in prison. The opposition believes this is another attempt by Orban to freedom of the press.

In China more than 81 thousand people fell ill COVID-19. 3 305 sick died, the quarantine regime was introduced in several provinces.The study of human rights organization Citizen Lab showed that Chinas censor even messages in social networks. The authorities tried to prevent the dissemination of information about the coronavirus even in the medical community since its introduction. Thus, they only exacerbated the situation.

One of those who first raised the alarm, was the doctor If Vanillan, which informed the colleagues about the new virus. Soon after that, Lee called the police and demanded an end to panic and make a public apology. A little later the doctor himself contracted the coronavirus died 7 Feb.

According to the research organization Citizen Lab, working on issues of Internet censorship under pressure from the government censored information and the most popular instant messenger of China WeChat. The researchers found that is now banned over 500 phrases associated with the theme of the coronavirus.

Among them Wuhan Communist party of China, crisis Beijing, Western medicine is a coronavirus, as well as the critics of the government to contain the epidemic. Some accounts were completely blocked, and their authors were put under surveillance.

the authorities of the Chinese province HangOU require citizens to use a special app Ant on smartphones for access to public places. It assigns each user to Hangzhou QR code green, yellow or red. It must be shown at the entrance to office buildings, residential buildings, shopping centres and public transport.

Code green means that the user can move freely in the province. The owners of the yellow code needs to spend a week at home in isolation. But those who have flashed code red, send to a mandatory two-week quarantine.

By the end of February codes were almost 90% of the provinces population (50 million people). More than one million of them received a yellow or red code. On what principle are assigned to the codes is unclear.

According to the Ant, the program automatically sinhroniziruete and analyzes large amounts of data, including on the movement of users, and then draws conclusions about the state of their health.

the Developer Ant is a system Alipay, which is Chinas 900 million users. According to the New York Times, with each scan code app records the location and reports it to the police.

According to journalists, in the future, a new application can become a tool of surveillance of the state over citizens. In Chinas state media write that the system will help the work of checkpoints at train stations and highways.

Digital concentration camp, in the words of the oppositionist Leonid Volkov, and prepares the city for Muscovites. Officials in a hurry to implement a massive system of spying on residents who are required to comply with the quarantine. On every exit from the house, including taking out the garbage, citizens will have to obtain special permission, in the form of a QR code, as in China. Special privilege bespreadtively to move will receive only security forces and other officials.

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Under the pretext of combating coronavirus States trying to crush the opposition and to tighten censorship - The KXAN 36 News

Corona Cover-Up? Videos The Chinese Government Would Rather You Don’t See Surface on The Internet – Talent Recap

Months after the Coronavirus outbreak began in the city of Wuhan, residents have only just been given the chance to collect the ashes of loved ones. In these recently released photos that have been censored, residents can be seen queuing for hours on end to collect the remains of lost family members.

Residents of Wuhan were seen queuing this week to collect the ashes of their close family members that have died to the Coronavirus. This is the first time residents have been able to collect ashes due to a past ban on operating cremation facilities. The city of Wuhan has been on lockdown for months ever since it was reported that it was the epicenter for the worlds first cases of Coronavirus.

RELATED: FEDERAL LAWSUIT FILED AGAINST CHINESE OFFICIALS CLAIMING INFORMATION ABOUT CORONAVIRUS WAS PURPOSELY HIDDEN

A similar practice has occurred at Wuhans Wuchang Funeral Home. The video below shows staff members calling out the names of those that have passed as ashes are given out. Audio in the video also claims that Cremation is free and that the government is giving out free urns to all those that visit. The validity of these statements is unknown.

SEE ALSO: HIDDEN DETAILS OF UFC FIGHTER JON JONES ARREST FOR NEGLIGENT GUN USE AND DUI

These photos were originally posted on social media site, Weibo. However, according to new claims, these photos have been censored from the site. In the past, it has been reported that Weibo works closely with the Chinese government to censor content. According to a whistleblower that worked at the site for 2 years, there are over 160 censorship employees working for Weibo.

Heres what the whistleblower told the CPJ about Weibos censorship program:

The Communist Party was terrified by Weibo, staring at it with fear and the determination to tame it The core of Weibo censorship is the lack of clear rules that users can follow. You dont know whether you will be the next target of censorship. Such tactics instill fear in you, then you start to behave yourself. Gradually, it becomes natural not to speak your mind. Over time, you lose the ability to express yourself as a normal person would do in a free society. That is the effect of censorship in the longrun.

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Corona Cover-Up? Videos The Chinese Government Would Rather You Don't See Surface on The Internet - Talent Recap

Reporters Without Borders: If the Chinese press were free, the coronavirus might not be a pandemic – Hong Kong Free Press

In ananalysispublished on March 13th, researchers from the University of Southampton suggest that the number of cases of coronavirus in China could have been reduced by 86% if the first measures, which were taken on January 20th, had been implemented two weeks earlier. Reporters Without Borders (RSF) demonstrates, based on the events in the early days of the crisis, that without the control and censorship imposed by the authorities, the Chinese media would have informed the public much earlier of the seriousness of the epidemic, saving thousands of lives and possibly avoiding the current pandemic.

Photojournalists at the National Peoples Congress. Photo: Lukas Messmer/HKFP.

October 18: Chinese press could have reported the chilling results of a pandemic simulation

The John Hopkins Center for Health Security, in partnership with the World Economic Forum and the Bill and Melinda Gates Foundation, carries out asimulatedcoronavirus pandemic onOctober 18th, 2019, andalertsthe international community to the chilling results: 65million deaths in 18months.

If the Chinese internet were not isolated by an elaborate system of electronic censorship and the media were not forced to follow the instructions of the Communist Party, the public and the authorities would have undoubtedly been interested in this informationcoming from the United States, which echoed the SARS (severe acute respiratory syndrome) epidemic of 2003. SARS infected 8,000 people and caused more than 800 deaths, mostly in China.

December 20: the Wuhan city authorities could have informed journalists

One month after thefirst documented case, the city of Wuhan already has 60patients with an unknown SARS-like pneumonia, several of whom havefrequentedthe Huanan fish market. Despite the situation, the authorities do not see fit to communicate this information to the media.

If the authorities had not hidden from the media the existence of an epidemic outbreak linkedto a very popular market, the public would have stopped visiting this place long before its official closure on January 1st.

December 25: Doctor Lu Xiaohong could have expressed fears to the press

Doctor Lu Xiaohong, the head of gastroenterology at Wuhan City Hospital No. 5, beginshearingcases ofinfectionaffecting medical staff on December 25 and suspects from the first week of January that the infection is transmissible between humans.

If journalists sources in China did not face severe penalties ranging from professional reprimand to heavy prison terms, Doctor Lu Xiaohong would have taken responsibility for alerting the media, forcing the authorities to take action, which only happened three weeks later.

Dr. Li Wenliang.

December 30: whistleblowers early warning would have been picked up by the media

The director of the emergency department at Wuhan Central Hospital, Ai Fen, and a group of doctors launch an alert regarding a SARS-like coronavirus. Eight of them, including DoctorLi Wenliang, who later died from the illness, will bearrestedby Wuhan police on January 3rd for circulatingfalse rumors.

If the press and social media had been able to freely relay the information transmitted by whistleblowers on December 30th, the public would have realised the danger and put pressure on the authorities to take measures limiting expansion of the virus.

December 31: social media would have relayed the official alert in China

Chinaofficially alertsthe World Health Organisation (WHO) on December 31st but at the same time forces the WeChat discussion platform tocensora large number of keywords referring to the epidemic.

Without censorship, the social network WeChat, which has a billion active users in China, could have enabled journalists to broadcast reports and precautionary advice contributing to better compliance with the rules recommended by the health authorities.

World Health Organization in Geneva, Switzerland. Photo: U.S. Mission Geneva/Eric Bridiers.

January 5: the scientific media would have disseminated the coronavirus genome earlier

Professor Zhang Yongzhens team at the Shanghai Public Health Clinical Centre manages to sequence the virus onJanuary 5th, but the authorities seem reluctant to make the genome public. On January 11th, the day China confirms its firstdeathfrom the virus, the researchers leak information on open source platforms, which will result in the punitive closure of their laboratory.

If the Chinese authorities were transparent, they would have immediately communicated the coronavirus genome sequence to the scientific media, saving the international community precious time in their research for the development of a vaccine.

January 13: the international community would have anticipated the risk of a pandemic

The first case of coronavirus infection outside of China, a tourist from Wuhan, is reported in Thailand.

If the international media had had full access to information held by the Chinese authorities on the scale of the epidemic before January 13th, it is likely that the international community would have taken stock of the crisis and better anticipated it, reducing the risk of the epidemic spreading outside China and possibly avoiding its transformation into a pandemic.

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Reporters Without Borders: If the Chinese press were free, the coronavirus might not be a pandemic - Hong Kong Free Press

Yann Joly on the fight against genetic discrimination – McGill Reporter

Yann Joly, Research Director of the Centre of Genomics and Policy

Research Director of the Centre of Genomics and Policy and Associate Professor at the Department of Human Genetics, Yann Joly is a Lawyer Emeritus from the Quebec Bar and a Fellow of the Canadian Academy of Health Sciences. He is currently a member of the Quebec task force on theCOVID-19 Biobank.

Last week, Joly and his collaborators from 16 countries announced the establishment of the international Genetic Discrimination Observatory (GDO). A world first, the GDO is an online platform committed to preventing the misuse of a patients genetic information. This is particularly important within the current context of the COVID-19 pandemic when researchers are collecting samples and data from patients in order to better understand this new disease and develop effective vaccines or therapeutics.

In this Q&A, Joly gives readers more information on genetic discrimination and what is being done to combat it.

Genetic discrimination (GD) means treating people differently from the rest of the population or unfairly profiling them based on actual or presumed genomic and other predictive medical data. The genetic information contained in an individuals DNA can uniquely identify or provide some information about a person, including future probabilities that this individual will develop diseases. Other predictive health information, such as biomarkers, can also be used to discriminate and should also be considered under the GD heading.

This information can be of interest to third parties like insurers, employers, or government officials. Like sexual, ethnic or disability-based discrimination, genetic discrimination is a source of exclusion and can limit the social and professional opportunities of a person thus becoming a source of psychological distress.

There are documented cases of GD reported in studies carried out in a limited number of countries based on predictive test results and family history for a handful of severe single-gene conditions in the context of life insurance or employment. The available evidence is fragmentary, and the methodology used in many studies is inconsistent.

The Genetic Non-Discrimination Act (hereinafter S-201) was passed in April 2017 and is currently applicable in Canada. While it does not solve all the challenges posed by genetic discrimination, it is an important first step. The Act generally makes it a criminal offense to require a person to undergo a genetic test or to report the results as a condition precedent to the provision of goods and services. However, the Quebec Court of Appeal recently declared that the core elements of S-201 were not constitutionally valid.

This decision was appealed to the Supreme Court of Canada and we are currently waiting for their decision on the matter. In the meantime, S-201 continue to be applied. If the Supreme Court is of a similar opinion to that of the Court of Appeal, it could be invalidated.

In addition to the protection provided by S-201, Canadian privacy laws would fully apply to genetic data, which is considered personal information.

Genetic information is increasingly shared across national borders or transcending them, thus limiting the effectiveness of protections built solely around national approaches. Strictly legal solutions, because they tend to be static, are also challenged to keep pace with rapidly evolving science such as genetics.

At its core discrimination is a social phenomenon that needs to be addressed collaboratively and internationally by all stakeholders. The GDO will provide the platform to undertake this important work, which will include documenting instances of genetic discrimination, identifying most effective preventing measures and conveying information, tools and good practices to all stakeholders including the public.

COVID-19 presents Quebecers with an unprecedented health threat that requires us to stand together as a society and take action to protect one another and help find medical solutions to the disease. The COVID-19 Biobank provides us a unique opportunity to learn more about the biological foundations of the disease, individuals at risk and preventive solutions.

The risk of discrimination associated with providing a biological sample and medical information to the Biobank is very small. The data provided is research information that is not clinically validated and should be of no interest to most third parties. Moreover, the collected information is coded, and protected by confidentiality laws and robust security measures. Furthermore, data access will be subject to ethics approval and in some cases controlled access measures.

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Yann Joly on the fight against genetic discrimination - McGill Reporter

Oldest human genetic data gleaned from 1.8-million-year-old tooth Haaretz – News Collective

Haaretz.com

***

Researchers have recovered the oldest human genetic information to date from two prehistoric teeth, one 1.77 million old and the other 800,000 years in age. The remains are so old they belong to a time that precedes the evolution of modern humans, i.e. Homo sapiens, so technically they are human only in the sense that they belong to some of our predecessors in the Homo evolutionary tree.The older of the two teeth was found in Dmanisi cave in Georgia and belonged to Homo erectus, the first hominin group known to have left Africa and spread throughout Eurasia.The second tooth was unearthed at a prehistoric site in Spains Atapuerca Mountains and belonged to a Homo antecessor, an enigmatic early human with a penchant for cannibalism whose evolutionary relationship to us has been the subject of much debate.The new research published Wednesday in Nature and led by scientists from the University of Copenhagen has provided a partial answer to that question, revealing that Homo antecessor was not a direct ancestor of Homo sapiens, as had been surmised by some.Both the analyzed samples precede by hundreds of thousands of years what was until now the oldest sequenced human genome, the 430,000-year-old DNA extracted from the remains of an early Neanderthal that was also found at Atapuerca.To achieve this huge leap forward or actually, backwards in the study of evolutionary genetics, the scientists used a new method that doesnt reconstruct ancient DNA but sequences proteins, in this case those found in the dental enamel, the hardest and most durable part of the human body.The Gran Dolina site in the Atapuerca Mountains , the only source of Homo antecessor boneAriel DavidSince proteins are built by our cells based on instructions from our nuclear DNA, the amino acid chains that form them represent a sort of mirror image of the nucleotides that form constitute our genetic code, explains Dr. Frido Welker, a molecular anthropologist at the University of Copenhagen.Breaking news and analyses in your inboxThank you for signing up.Weve got more newsletters we think youll find interesting.Click hereOops. Something went wrong.Please try again later.Try againThank you,The email address you have provided is already registered.CloseJust like DNA sequences, these protein sequences will be slightly different between different people, populations and species in a manner that is determined by their evolution, Welker tells Haaretz. So by comparing sequences from different prehistoric and modern populations, experts can approximate how closely related these ancient groups are to each other.The advantage of hunting for proteins instead of DNA is that the latter molecule tends to degrade faster, says Enrico Cappellini a professor at the University of Copenhagen and one the lead authors on the Nature study.Until now, the oldest animal DNA sequenced has been that of a 700,000-year-old horse and that was only because its remains had been preserved by Canadas permafrost. By using palaeoproteomics (the study of ancient proteins), the same Danish team has published protein sequences from a 1.77-million-year-old rhino found at Dmanisi, as well as a 1.9-million-year old Gigantopithecus, an extinct great ape from China.Of course, even this new approach has limits. So if you have nightmares about being chased by a velociraptor in a Jurassic-Park-like scenario, then know we are still very far away from sequencing the proteins let alone the DNA of dinosaurs who went extinct 65 million years ago.In fact, even the 1.77-million-year old protein sequence belonging to the Homo erectus from Dmanisi was too short and damaged to be of much use to the authors of the new study, Welker says. It still stands as the oldest genetic information we have gathered on a human ancestor, but it cannot tell us anything about the evolutionary link between erectus and sapiens.Digital reconstruction of specimen ATD6-69 from the Homo antecessor collection. Computerized microtomography techniques were used to perform this reconstructionProf. Laura Martn-FrancsClose, but no ancestorThe study of the Homo antecessor tooth was, on the other hand, much more revealing.Remains of this hominin have been found only at that one site in Spains Atapuerca Mountains, though some prehistoric stone tools unearthed in France and Britain suggest it may have been present there too between 1.2 and 0.8 million years ago. Very little is known about their behavior, apart from the fact that some of their bones were skillfully butchered, which has been interpreted as the earliest evidence of human cannibalism.Still, some scholars have theorized that antecessor may have played an outsize role in our evolution.As hinted by its Latin name, which means predecessor or ancestor, the hypothesis is that this elusive hominin was the last common ancestor of Homo sapiens, Neanderthal and Denisovan, the main hominin groups that inhabited the Earth over the last half-million years. The theory is based on the fact that antecessor shares some features with later hominins, especially a relatively modern-looking face. Also, the time span of antecessors existence fits well with other studies suggesting that the lineages that eventually led to the evolution of Neanderthals, sapiens and Denisovans split off some time before 750,000 years ago.But the Nature study, titled The dental proteome of Homo antecessor, does not support this theory. Once the recovered protein sequences were compared to those of other hominins, it became apparent that antecessor could only be a sister group of that mysterious common ancestor we share with Neanderthals and Denisovans.The Gran Dolina site in the Atapuerca Mountains , the only source of Homo antecessor bonesAriel DavidThe caveat is that it is difficult to establish how closely related they were to the common ancestor, Welker tells Haaretz. In other words, we are relatives, but antecessor is not on the same branch as us in the evolutionary tree.Personally, I am glad that our ancestors did not diverge from a group of cannibals, jokes Prof. Israel Hershkovitz, a physical anthropologist from Tel Aviv University.The recovery of the protein sequences from the erectus and antecessor teeth is an impressive technical feat, says Hershkovitz, who did not take part in the study.Palaeoproteomics allows us to gain insights about earlier times than by using DNA, but it is also a more limited tool that, as the authors stated, can only give us a best guess as to the placement of Homo antecessor in relation to later hominin groups, he cautions.The studys conclusion that antecessor was a parallel group to one of our distant ancestors does contribute to the growing evidence suggesting that human evolution is anything but a straight line in which one type of hominin evolves into the next one, Welker notes. Research over the last years has shown that our evolutionary history resembles more a tangled bush in which different populations evolved in parallel, coexisted and mixed continuously.Many questions remain unanswered, such as the identity of that missing link between us and our closest evolutionary cousins, the Neanderthals and Denisovans, Welker says. But the newfound ability to glean at least some genetic material from hominin remains that are millions of years old does hint that maybe we will be able to crack that mystery soon, as well as other open questions about our distant origins.The Sima de los Huesos, or Bone pit in the Atapuerca Mountains, where dozens of Neanderthal bodies were foundAriel DavidThe Sima de los Huesos, or Bone pit in the Atapuerca Mountains, where dozens of Neanderthal bodies were foundAriel David

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Oldest human genetic data gleaned from 1.8-million-year-old tooth Haaretz - News Collective

Science to the rescue? How modern genetics could help save the world from coronavirus – Genetic Literacy Project

Humanity really has only two options to confront the coronavirus pandemic currently sweeping the planet. The first is to mount a rolling program of lockdowns and other drastic social distancing strategies to restrain the pace of the virus epidemic, with a view to gradually building up natural herd immunity among the human population.

That strategy, especially if combined with successful anti-viral drug treatments and a massively upscaled testing effort, should give some relief. But it would come at the likely cost of many millions of deaths and incalculable worldwide economic damage, hitting especially hard in countries with little resilience and limited healthcare infrastructure.

The second approach is to develop a vaccine, and to do so as rapidly as possible. A fully effective vaccine would not just tame COVID-19 but possibly eradicate it altogether as the world successfully did with smallpox and is on the verge of doing with polio (both also viral diseases).

These two approaches will most likely be concurrent: the first will buy us time, while the second provides an exit strategy from a constant pattern of repeating lockdowns and travel restrictions that could otherwise go on for years.

With the current total of confirmed cases rapidly closing in on one million worldwide, the true picture is most likely that many tens of millions of people have already caught COVID-19. Humanitys most desperate challenge, therefore, is to find an effective vaccine.

Fortunately, science is already stepping up. History was made on March 16, when the first clinical trial volunteer was injected with an investigational vaccine for coronavirus at the Kaiser Permanente Washington Health Research Institute in Seattle.

The volunteer was mother-of-two Jennifer Haller, a 43-year-old Seattle resident who told National Public Radio that she wanted to do something because theres so many Americans that dont have the same privileges that Ive been given.

The vaccination was produced by Moderna, with the first batch being delivered to the US National Institutes of Health a remarkable 42 days after the viral genome was first sequenced in China.

This Phase 1 trial does not yet test the efficacy of the vaccine against COVID-19. Carried out over six weeks among a group of 45 healthy adult volunteers aged between 18 and 55, it will test the basic safety of the proposed vaccine and its ability to stimulate an immune response in the human body.

Although the Phase 1 trial will continue with the Seattle-area recruits being monitored for a whole year, the urgency of the global situation means that the collaborators will likely rush to Phase 2 at the same time, testing the ability of the vaccine to prevent infection by the novel coronavirus SARS-CoV-2 that causes COVID-19.

The Moderna vaccine trial is a world first not just for the particular disease target but because it is one of a whole new potential class of vaccines that employ messenger RNA (mRNA) to program human cells to produce the viral proteins that trigger an immune response, rather than injecting proteins or viral particles directly, as have most previous vaccines.

This natural role of mRNA is why Modernas approach is so quick. Normal vaccines have to be produced from actual viruses, which are grown within chicken eggs and then refined into sufficient quantities to be directly injected once weakened or killed into the human body. This takes months, at a minimum, and is difficult to scale quickly.

For the mRNA approach, all that was needed was the correct viral genetic sequence, which in the case of SARS-CoV-2 encodes for the spike proteins that enable the virus to gain entry into human respiratory cells. This genetic sequence for the viral protein can then be encoded into mRNA synthetically generated in a lab a rapid process that is easy to scale.

Thats the good news. The bad news is that the mRNA approach, while undoubtedly quick and versatile, is so new that it has yet to be fully proven in any vaccine in either humans or animals. Some tests have shown efficacy against rabies, for example, but others have shown little lasting immune response.

The mRNA approach is therefore a moon-shot rather than a marathon. Even so, Moderna is optimistic enough to already be making plans to produce millions of doses intended for health workers initially as early as this fall.

Other companies and partnerships are also racing to develop a vaccine using the same mRNA approach. One of these, the German firm CureVac, generated so much interest that President Trump reportedly tried to acquire it in order to ensure any potential vaccine would be available to Americans first.

Like Moderna, CureVacs efforts are supported financially by CEPI the international Coalition for Epidemic Preparedness Innovations, which has raised over $700 million from governments around the world and philanthropic foundations like the Bill & Melinda Gates Foundation (which also supports the Cornell Alliance for Science) and Wellcome.

While Moderna has been able to restart vaccine projects originally intended for MERS and SARS, CureVac has already achieved some success with an mRNA vaccine against rabies virus in humans. In a Phase 1 trial doses as low as a millionth of a gram of mRNA vaccine were sufficient to fully protect humans against rabies, it reported in January.

Such small doses offer major promise for immunizing huge numbers of people if CureVac is able to achieve the same success with SARS-CoV-2 as it has with rabies and move rapidly into Phase 2 trials to further demonstrate real efficacy.

Also in Germany, BioNTech and Pfizer are racing to shift their mRNA vaccine work from influenza to SARS-CoV-2, and are aiming to start clinical trials as soon as April. As part of a broader collaboration, BioNTech has already demonstrated that an mRNA vaccine protected mice and non-human primates against Zika virus, raising hopes for similar effectiveness against COVID-19.

RNAs double-stranded cousin, DNA, is also being deployed in a novel but equally promising vaccine system against the coronavirus. The approach is related, but rather than injecting mRNA directly into cells so that it can produce viral proteins, DNA is inserted, which in turn produces mRNA inside cells to do the same job.

This DNA is not intended to integrate into the genome of the target cell in humans indeed if this happens, damaging mutations might occur. Instead, DNA is formed into circular plasmids which operate separately to the integral genetic material inside a cells nucleus. Like genomic DNA however, these plasmids are read and transcribed via mRNA into viral proteins which can then prime the bodys immune system against a later invasion by the real virus.

The US-based Inovio Pharmaceuticals announced on 12 March that it had received a grant of $5 million from the Bill & Melinda Gates Foundation to accelerate the testing of a DNA vaccine for COVID-19, with a view to starting Phase 1 clinical trials in April.

Inovio has another advantage: its DNA vaccine INO-4700 was the only vaccine candidate against MERS to progress to Phase 2 trials demonstrating, at least initially, the potential feasibility of the DNA approach. The US Department of Defense with an eye to protecting its military personnel all over the world against COVID-19 has pumped another $11.9 million into INO-4800. The company has also demonstrated protection in early trials using its DNA vaccine against Chikungunya, Zika and influenza viruses.

CEPI is not putting all its eggs in one basket, however. As well as DNA and RNA systems, another promising approach for a COVID-19 vaccine is to use a genetically engineered measles vaccine a strategy supported by a $5 million CEPI grant split between collaborating institutions Themis in Vienna, Institut Pasteur in France and the University of Pittsburghs Center for Vaccine Research.

This takes the live attenuated measles virus vaccine a vaccine with a long history of safe use, having been used to immunize billions of children over the last 40 years and uses reverse genetics technology to insert new genes coding for proteins expressed by other viruses. These then induce an immune response against the new virus whose genetic material has been introduced.

The research team aims to have a COVID-19 candidate vaccine ready for animal testing as soon as April, with wider tests in human volunteers by the end of the year.

Measles virus is not the only candidate for the vector approach. Chinese scientists have reported that they are about to proceed to Phase I human trials with a vaccine candidate starting at the pandemics epicenter in Wuhan. The scientists have genetically engineered a replication-defective adenovirus type 5 (Ad5) as a vector to express the SARS-CoV-2 spike protein, with the resulting vaccine candidate named Ad5-nCoV.

This is perhaps the easiest approach, as all that has to happen is for the engineered harmless adenovirus to infect patients in order to trigger the production of antibodies which should be effective against invading novel coronavirus too. The Chinese company CanSion Biologics has successfully demonstrated this approach with another fully completed vaccine against Ebola, Ad5-EBOV, which is already on the market in China.

A more tried-and-tested approach already widely used to produce flu vaccines is to grow viral proteins directly: these are then injected as a vaccine into human patients so that the immune system is already primed against the real pathogen when it attempts to infect the body. Usually chicken eggs are used, but to speed things up insect cell lines are becoming the preferred option for the coronavirus pandemic.

Here genetics is again an important component: the company Novavax uses a baculovirus vector to genetically engineer an insect cell line originally isolated decades ago from the ovaries of the fall armyworm. The baculovirus transports genes into the insect cells, which program them to manufacture viral proteins that are correctly folded and biologically active, more reliably enabling the human immune system to produce antibodies against them.

According to Novavax, its resulting recombinant protein nanoparticles then self-assemble into a structure that approximates the actual virus, helping enhance the immune response. It claims to have already tested this system in RSV virus, a recalcitrant pathogen that has so far resisted attempts at a vaccine. This approach looks promising enough that CEPI has pumped $4 million in so far with a view to launching Phase I trials by late spring 2020.

In a similar way, the company Sanofi is taking a snippet of genetic code from SARS-CoV-2 and splicing it also via baculovirus into insect cell lines. Its advantage, made in a pitch to the US government that resulted in a big cash injection, is that it already has an FDA-approved facility that could make 600 million doses a year of any resulting vaccine.

Plants can also be engineered to produce viral proteins. The company Medicago is working with genetically modified tobacco plants with this aim in mind. To speed things up, instead of adding new genes to the nucleus of cells and regenerating entire plants from these single cells (as happens with conventional plant genetic engineering), it uses the Agrobacterium vector in a vacuum to transfer recombinant DNA directly into the nucleus of fully-grown leaf cells. This DNA enables the production of the desired viral proteins without ever being integrated into the genome, enabling proteins to be harvested from transformed leaves within a matter of days.

Using this system, Medicago claims to have produced a virus-like particle of the coronavirus within just 20 daysof the SARS-CoV-2 genetic sequence becoming available. The government of Canada quickly put millions of dollars behind the effort as a result.

Astonishingly, given that the coronavirus pandemic is now threatening to devastate societies and economies around the planet on a scale second only to a world war, this effort is still short of cash. CEPI has issued an urgent call for funding, seeking to raise $2 billion: it says just $375 billion by the end of March would enable four-to-six vaccine candidates to move rapidly towards phase 2/3 trials.

Scientists are also hoping desperately that SARS-CoV-2 does not rapidly mutate as influenza viruses tend to do, which would likely reduce the effectiveness of any single vaccine. So far, according to researchers studying 1,000 samples of the virus from around the world, this seems not to be the case.

This means that the race to find a vaccine, and to do so in sufficient time to salvage the situation before the world tips into an economic depression and millions of people die, has a decent chance of success and that any successful vaccine would likely confer lasting immunity.

Meanwhile, all of humanity is waiting. And if the scientists do succeed in this urgent challenge, it will very likely be due to modern genetics. Though genetic engineering was once a dirty word, it now could literally help save the world.

This article originally ran at theCornell Alliance for Scienceand has been republished here with permission. Follow the Alliance for Science on Twitter @ScienceAlly. Follow Mark Lynas on Twitter @mark_lynas

The rest is here:

Science to the rescue? How modern genetics could help save the world from coronavirus - Genetic Literacy Project

Science to the rescue? How modern genetics could help save the world from coronavirus – Alliance for Science – Alliance for Science

Humanity really has only two options to confront the coronavirus pandemic currently sweeping the planet. The first is to mount a rolling program of lockdowns and other drastic social distancing strategies to restrain the pace of the virus epidemic, with a view to gradually building up natural herd immunity among the human population.

That strategy, especially if combined with successful anti-viral drug treatments and a massively upscaled testing effort, should give some relief. But it would come at the likely cost of many millions of deaths and incalculable worldwide economic damage, hitting especially hard in countries with little resilience and limited healthcare infrastructure.

The second approach is to develop a vaccine, and to do so as rapidly as possible. A fully effective vaccine would not just tame COVID-19 but possibly eradicate it altogether as the world successfully did with smallpox and is on the verge of doing with polio (both also viral diseases).

These two approaches will most likely be concurrent: the first will buy us time, while the second provides an exit strategy from a constant pattern of repeating lockdowns and travel restrictions that could otherwise go on for years.

With the current total of confirmed cases rapidly closing in on one million worldwide, the true picture is most likely that many tens of millions of people have already caught COVID-19. Humanitys most desperate challenge, therefore, is to find an effective vaccine.

Fortunately, science is already stepping up. History was made on March 16, when the first clinical trial volunteer was injected with an investigational vaccine for coronavirus at the Kaiser Permanente Washington Health Research Institute in Seattle.

The volunteer was mother-of-two Jennifer Haller, a 43-year-old Seattle resident who told National Public Radio that she wanted to do something because theres so many Americans that dont have the same privileges that Ive been given.

The vaccination was produced by Moderna, with the first batch being delivered to the US National Institutes of Health a remarkable 42 days after the viral genome was first sequenced in China.

This Phase 1 trial does not yet test the efficacy of the vaccine against COVID-19. Carried out over six weeks among a group of 45 healthy adult volunteers aged between 18 and 55, it will test the basic safety of the proposed vaccine and its ability to stimulate an immune response in the human body.

Although the Phase 1 trial will continue with the Seattle-area recruits being monitored for a whole year, the urgency of the global situation means that the collaborators will likely rush to Phase 2 at the same time, testing the ability of the vaccine to prevent infection by the novel coronavirus SARS-CoV-2 that causes COVID-19.

The Moderna vaccine trial is a world first not just for the particular disease target but because it is one of a whole new potential class of vaccines that employ messenger RNA (mRNA) to program human cells to produce the viral proteins that trigger an immune response, rather than injecting proteins or viral particles directly, as have most previous vaccines.

This natural role of mRNA is why Modernas approach is so quick. Normal vaccines have to be produced from actual viruses, which are grown within chicken eggs and then refined into sufficient quantities to be directly injected once weakened or killed into the human body. This takes months, at a minimum, and is difficult to scale quickly.

For the mRNA approach, all that was needed was the correct viral genetic sequence, which in the case of SARS-CoV-2 encodes for the spike proteins that enable the virus to gain entry into human respiratory cells. This genetic sequence for the viral protein can then be encoded into mRNA synthetically generated in a lab a rapid process that is easy to scale.

Thats the good news. The bad news is that the mRNA approach, while undoubtedly quick and versatile, is so new that it has yet to be fully proven in any vaccine in either humans or animals. Some tests have shown efficacy against rabies, for example, but others have shown little lasting immune response.

The mRNA approach is therefore a moon-shot rather than a marathon. Even so, Moderna is optimistic enough to already be making plans to produce millions of doses intended for health workers initially as early as this fall.

Other companies and partnerships are also racing to develop a vaccine using the same mRNA approach. One of these, the German firm CureVac, generated so much interest that President Trump reportedly tried to acquire it in order to ensure any potential vaccine would be available to Americans first.

Like Moderna, CureVacs efforts are supported financially by CEPI the international Coalition for Epidemic Preparedness Innovations, which has raised over $700 million from governments around the world and philanthropic foundations like the Bill & Melinda Gates Foundation (which also supports the Cornell Alliance for Science) and Wellcome.

While Moderna has been able to restart vaccine projects originally intended for MERS and SARS, CureVac has already achieved some success with an mRNA vaccine against rabies virus in humans. In a Phase 1 trial doses as low as a millionth of a gram of mRNA vaccine were sufficient to fully protect humans against rabies, it reported in January.

Such small doses offer major promise for immunizing huge numbers of people if CureVac is able to achieve the same success with SARS-CoV-2 as it has with rabies and move rapidly into Phase 2 trials to further demonstrate real efficacy.

Also in Germany, BioNTech and Pfizer are racing to shift their mRNA vaccine work from influenza to SARS-CoV-2, and are aiming to start clinical trials as soon as April. As part of a broader collaboration, BioNTech has already demonstrated that an mRNA vaccine protected mice and non-human primates against Zika virus, raising hopes for similar effectiveness against COVID-19.

RNAs double-stranded cousin, DNA, is also being deployed in a novel but equally promising vaccine system against the coronavirus. The approach is related, but rather than injecting mRNA directly into cells so that it can produce viral proteins, DNA is inserted, which in turn produces mRNA inside cells to do the same job.

This DNA is not intended to integrate into the genome of the target cell in humans indeed if this happens, damaging mutations might occur. Instead, DNA is formed into circular plasmids which operate separately to the integral genetic material inside a cells nucleus. Like genomic DNA however, these plasmids are read and transcribed via mRNA into viral proteins which can then prime the bodys immune system against a later invasion by the real virus.

The US-based Inovio Pharmaceuticals announced on 12 March that it had received a grant of $5 million from the Bill & Melinda Gates Foundation to accelerate the testing of a DNA vaccine for COVID-19, with a view to starting Phase 1 clinical trials in April.

Inovio has another advantage: its DNA vaccine INO-4700 was the only vaccine candidate against MERS to progress to Phase 2 trials demonstrating, at least initially, the potential feasibility of the DNA approach. The US Department of Defense with an eye to protecting its military personnel all over the world against COVID-19 has pumped another $11.9 million into INO-4800. The company has also demonstrated protection in early trials using its DNA vaccine against Chikungunya, Zika and influenza viruses.

CEPI is not putting all its eggs in one basket, however. As well as DNA and RNA systems, another promising approach for a COVID-19 vaccine is to use a genetically engineered measles vaccine a strategy supported by a $5 million CEPI grant split between collaborating institutions Themis in Vienna, Institut Pasteur in France and the University of Pittsburghs Center for Vaccine Research.

This takes the live attenuated measles virus vaccine a vaccine with a long history of safe use, having been used to immunize billions of children over the last 40 years and uses reverse genetics technology to insert new genes coding for proteins expressed by other viruses. These then induce an immune response against the new virus whose genetic material has been introduced.

The research team aims to have a COVID-19 candidate vaccine ready for animal testing as soon as April, with wider tests in human volunteers by the end of the year.

Measles virus is not the only candidate for the vector approach. Chinese scientists have reported that they are about to proceed to Phase I human trials with a vaccine candidate starting at the pandemics epicenter in Wuhan. The scientists have genetically engineered a replication-defective adenovirus type 5 (Ad5) as a vector to express the SARS-CoV-2 spike protein, with the resulting vaccine candidate named Ad5-nCoV.

This is perhaps the easiest approach, as all that has to happen is for the engineered harmless adenovirus to infect patients in order to trigger the production of antibodies which should be effective against invading novel coronavirus too. The Chinese company CanSion Biologics has successfully demonstrated this approach with another fully completed vaccine against Ebola, Ad5-EBOV, which is already on the market in China.

A more tried-and-tested approach already widely used to produce flu vaccines is to grow viral proteins directly: these are then injected as a vaccine into human patients so that the immune system is already primed against the real pathogen when it attempts to infect the body. Usually chicken eggs are used, but to speed things up insect cell lines are becoming the preferred option for the coronavirus pandemic.

Here genetics is again an important component: the company Novavax uses a baculovirus vector to genetically engineer an insect cell line originally isolated decades ago from the ovaries of the fall armyworm. The baculovirus transports genes into the insect cells, which program them to manufacture viral proteins that are correctly folded and biologically active, more reliably enabling the human immune system to produce antibodies against them.

According to Novavax, its resulting recombinant protein nanoparticles then self-assemble into a structure that approximates the actual virus, helping enhance the immune response. It claims to have already tested this system in RSV virus, a recalcitrant pathogen that has so far resisted attempts at a vaccine. This approach looks promising enough that CEPI has pumped $4 million in so far with a view to launching Phase I trials by late spring 2020.

In a similar way, the company Sanofi is taking a snippet of genetic code from SARS-CoV-2 and splicing it also via baculovirus into insect cell lines. Its advantage, made in a pitch to the US government that resulted in a big cash injection, is that it already has an FDA-approved facility that could make 600 million doses a year of any resulting vaccine.

Plants can also be engineered to produce viral proteins. The company Medicago is working with genetically modified tobacco plants with this aim in mind. To speed things up, instead of adding new genes to the nucleus of cells and regenerating entire plants from these single cells (as happens with conventional plant genetic engineering), it uses the Agrobacterium vector in a vacuum to transfer recombinant DNA directly into the nucleus of fully-grown leaf cells. This DNA enables the production of the desired viral proteins without ever being integrated into the genome, enabling proteins to be harvested from transformed leaves within a matter of days.

Using this system, Medicago claims to have produced a virus-like particle of the coronavirus within just 20 daysof the SARS-CoV-2 genetic sequence becoming available. The government of Canada quickly put millions of dollars behind the effort as a result.

Astonishingly, given that the coronavirus pandemic is now threatening to devastate societies and economies around the planet on a scale second only to a world war, this effort is still short of cash. CEPI has issued an urgent call for funding, seeking to raise $2 billion: it says just $375 billion by the end of March would enable four-to-six vaccine candidates to move rapidly towards phase 2/3 trials.

Scientists are also hoping desperately that SARS-CoV-2 does not rapidly mutate as influenza viruses tend to do, which would likely reduce the effectiveness of any single vaccine. So far, according to researchers studying 1,000 samples of the virus from around the world, this seems not to be the case.

This means that the race to find a vaccine, and to do so in sufficient time to salvage the situation before the world tips into an economic depression and millions of people die, has a decent chance of success and that any successful vaccine would likely confer lasting immunity.

Meanwhile, all of humanity is waiting. And if the scientists do succeed in this urgent challenge, it will very likely be due to modern genetics. Though genetic engineering was once a dirty word, it now could literally help save the world.

See the rest here:

Science to the rescue? How modern genetics could help save the world from coronavirus - Alliance for Science - Alliance for Science

BHU department claims to have discovered new technology to test COVID-19 – Jagran Josh

The Department of Molecular & Human Genetics has claimed that it has discovered a new technology to test COVID-19 virus and give accurate results within 5-6 hours.

Sangeeta NairMar 31, 2020 14:04 IST

The Department of Molecular & Human Genetics at the Banaras Hindu University has claimed that it has discovered a new technology to test the COVID-19 virus and give accurate results within 5-6 hours.

The departments Associate Professor Dr. Geeta Rai stated that the department had tried to target a protein sequence present only in the COVID-19 virus. We've tried to target a protein sequence present only in COVID19 & not present in any other viral strain, she said.

Dr. Rai added saying, We're hopeful when testing is done it will only detect COVID19 presence, so there'll be less chance of false detection.

The new technology has been developed by an all-women team of BHUs Department of Molecular & Human Genetics. The team includes four researchers- Dr. Geeta Rai, Dolly Das, Khushbupriya and Hiral Thakar.

The research team had filed a patent on March 27, 2020. However, it needs to be validated by the Indian virology research institute- The National Institute of Virology in Pune and after that it would require approval from the Indian Council of Medical Research.

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BHU department claims to have discovered new technology to test COVID-19 - Jagran Josh

Stealth BioTherapeutics Reports Fiscal Year 2019 Financial Results And Recent Business Highlights – BioSpace

BOSTON, April 1, 2020 /PRNewswire/ --Stealth Biotherapeutics Corp (NASDAQ: MITO), a clinical-stage biotechnology company focused on the discovery, development and commercialization of novel therapies for diseases involving mitochondrial dysfunction, today reported financial results for the year ended December 31, 2019 and announced recent business highlights.

"We are off to a strong start in 2020, having honed our focus on Barth and our planned expansion into other rare metabolic cardiomyopathies, while continuing to execute on the significant promise of our ophthalmic and other pipeline programs. By decisively reducing expenses in January, our cash and cash equivalents are sufficient through key Barth regulatory interactions in the second half of 2020, bringing us closer to a potential approval with an opportunity for a rare pediatric voucher and expedited regulatory review," said Reenie McCarthy, Chief Executive Officer at Stealth. "We hope to complete enrollment of our Phase 2b study in dry AMD during the second half of this year, keeping us on-track for a second half of 2021 top-line read-out. We are actively planning development initiatives in other rare metabolic cardiomyopathies, on which we hope to engage with the FDA this year. We are also rapidly advancing our pipeline of novel mitochondrial medicines, with SBT-272 being assessed in a Phase 1 clinical trial, preclinical data read-outs expected this year for SBT-272 in amyotrophic lateral sclerosis and multiple system atrophy and SBT-259 in Charcot-Marie-Tooth, and lead optimization underway for our SBT-550 series, targeting the ferroptosis pathway of cell death implicated in neurodegenerative diseases such as Parkinson's."

Fourth Quarter 2019 and Recent Highlights

Key Upcoming Milestones

2019 Financial Results

Revenue: In 2019, the Company recognized $21.1 million in revenue associated with the Alexion arrangement. The revenue represents the portion of the non-refundable upfront payments that were recognized in full upon the delivery of the topline data for the Company's MMPOWER-3 trial. Alexion terminated the arrangement and as such, no additional revenue will be recognized.

Research and Development (R&D) Expenses:R&D expenses decreased by $8.5 million to $44.6 million for the year ended December 31, 2019, from $53.1 million for the year ended December 31, 2018. This decrease was primarily from a net decrease of $8.5 million in clinical trial costs due to the timing of trials that ended in 2018, a $2.8 million decrease in contract manufacturing, and a $0.9 million decrease in discovery related expenses due to timing of activities. These decreases were offset in part by increases of $3.6 million in employee and consultant related expenses driven by continued build-out of clinical, medical affairs and regulatory functions and $0.1 million in other costs.

General and Administrative (G&A) Expenses: G&A expenses increased by $0.1 million to $22.3 million for the year ended December 31, 2019, from $22.2 million for the year ended December 31, 2018. The increase was primarily attributable to a net $2.3 million increase in pre-commercial activities including building market disease awareness, a $1.8 million increase in professional services for activities attributable to operating as a public company, an increase of $3.2 million in employee related costs offset by a decrease of $6.7 million in costs associated with 2018 financing efforts and a decrease in IP legal fees of $0.5 million.

Other Expenses: Other expenses increased by $4.5 million to $25.9 million for the year ended December 31, 2019 from $21.4 million for the year ended December 31, 2018. The increase in other expenses is primarily attributable to a $22.7 million loss on extinguishment of debt recorded with respect to convertible debt conversion into ordinary shares in conjunction with the Company's 2019 initial public offering and a $0.7 million change period over period in the fair value adjustments of the warrant liability. These increases were offset by a $3.4 million change in period over period fair value adjustments of the derivative liability associated with the convertible debt, a decrease in interest expense mostly related to the convertible debt of $14.7 million and an increase in interest income of $0.8 million.

Cash Position: Cash and cash equivalents were $50.8 million at December 31, 2019, compared to $10.9 million at December 31, 2018.

Conference Call

Management will host a conference call today at8:30 am ETto discuss the financial results and provide a general business update. The call can be accessed by dialing (877) 407-0989 or (201) 389-0921 (international) and referencing conference ID 13701108. A live audio webcast of the event can be accessed by visiting the Investors & News section of Stealth's Investor website,https://investor.stealthbt.com/. A replay of the webcast will be archived on Stealth's website for 30 days following the event.

About Stealth

We are a clinical-stage biotechnology company focused on the discovery, development and commercialization of novel therapies for diseases involving mitochondrial dysfunction. Mitochondria, found in nearly every cell in the body, are the body's main source of energy production and are critical for normal organ function. Dysfunctional mitochondria characterize a number of rare genetic diseases and are also involved in many common age-related diseases, typically involving organ systems with high energy demands such as the heart, the eye, and the brain. We believe our lead product candidate, elamipretide, has the potential to treat both rare metabolic cardiomyopathies, such as Barth, Duchenne and Becker muscular dystrophies and Friedreich's ataxia, as well as ophthalmic diseases entailing mitochondrial dysfunction, such as dry age-related macular degeneration and Leber's hereditary optic neuropathy. We are evaluating our second-generation clinical stage candidate, SBT-272, for rare neurodegenerative disease indications following promising preclinical data in amyotrophic lateral sclerosis, or ALS. Our pipeline compounds include SBT-259, which we are evaluating for rare peripheral neuropathies, and the SBT-550 series of compounds, which we plan to evaluate for rare neurodegenerative and ophthalmic indications. We have optimized our discovery platform to identify novel mitochondria-targeted compounds, which may be nominated as therapeutic product candidates or utilized as scaffolds to deliver other compounds to mitochondria. We have assembled a highly experienced management team, board of directors and group of scientific advisors to help us achieve our mission of leading mitochondrial medicine.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Such forward-looking statements include those regarding Stealth BioTherapeutics' plans, strategies and expectations for its preclinical and clinical advancement of its drug development programs, including its ongoing clinical trials of elamipretide and planned clinical trial of SBT-272; the potential benefits of Stealth BioTherapeutics' product candidates; its key milestones for 2020; its plans regarding future data presentations; and its financial guidance regarding the period in which it will have capital available to fund its operations. Statements that are not historical facts, including statements about Stealth BioTherapeutics' beliefs, plans and expectations, are forward-looking statements. The words "anticipate," "expect," "hope," "plan," "potential," "possible," "will," "believe," "estimate," "intend," "may," "predict," "project," "would" and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Stealth BioTherapeutics may not actually achieve the plans, intentions or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements as a result of known and unknown risks, uncertainties and other important factors, including: Stealth BioTherapeutics' ability to obtain additional funding and to continue as a going concern; the impact of the COVID-19 pandemic; the ability to successfully demonstrate the efficacy and safety of Stealth BioTherapeutics' product candidates and future product candidates; the preclinical and clinical results for Stealth BioTherapeutics' product candidates, which may not support further development and marketing approval; the potential advantages of Stealth BioTherapeutics' product candidates; the content and timing of decisions made by the U.S. FDA, the EMA or other regulatory authorities, investigational review boards at clinical trial sites and publication review bodies, which may affect the initiation, timing and progress of preclinical studies and clinical trials of Stealth BioTherapeutics product candidates; Stealth BioTherapeutics' ability to obtain and maintain requisite regulatory approvals and to enroll patients in its planned clinical trials; unplanned cash requirements and expenditures; competitive factors; Stealth BioTherapeutics' ability to obtain, maintain and enforce patent and other intellectual property protection for any product candidates it is developing; and general economic and market conditions. These and other risks are described in greater detail under the caption "Risk Factors" included in the Stealth BioTherapeutics' most recent Annual Report on Form 20-F filed with the Securities and Exchange Commission ("SEC"), as well as in any future filings with the SEC. Forward-looking statements represent management's current expectations and are inherently uncertain. Except as required by law, Stealth BioTherapeutics does not undertake any obligation to update forward-looking statements made by us to reflect subsequent events or circumstances.

Investor RelationsStern Investor RelationsLauren Stival, 212-362-1200IR@StealthBT.com

STEALTH BIOTHERAPEUTICS CORP

Condensed Consolidated Balance Sheets

(inthousands)

December 31,

December 31,

2019

2018

Assets

Current assets:

Cash and cash equivalents

$ 50,768

$ 10,855

Prepaid expenses and other current assets

1,630

2,438

Total current assets

52,398

13,293

Property and equipment, net

345

499

Deferred offering costs

1,325

Other non-current assets

406

Total assets

$ 52,743

$ 15,523

Liabilities, convertible preferred shares andshareholders' equity (deficit)

Current liabilities:

Accounts payable

$ 9,520

$ 11,023

Accrued expenses and other current liabilities

8,495

13,826

Accrued interest payable

1,219

7,297

Current portion of long-term debt

14,716

8,465

Total current liabilities

33,950

40,611

Long-term debt, less current portion

1,526

10,317

Convertible notes payable

103,257

Derivative liability

36,567

Warrant liability

100

Total liabilities

35,476

190,852

Series A convertible preferred shares

211,377

Total shareholders' equity (deficit)

17,267

(386,706)

Total liabilities, convertible preferred shares andshareholders' equity (deficit)

$ 52,743

$ 15,523

STEALTH BIOTHERAPEUTICS CORP

Condensed Consolidated Statements of Operations

(inthousands,exceptshareandpersharedata)

Year Ended December 31,

2019

2018

Revenue

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Stealth BioTherapeutics Reports Fiscal Year 2019 Financial Results And Recent Business Highlights - BioSpace

Researchers at U of T developing antibodies to ‘neutralize’ novel coronavirus before it invades cells – News@UofT

Universityof Toronto researcherSachdev Sidhuand his collaborators are engineering antibody molecules that can neutralize the novel coronavirus in the body before it invades cells.

Sidhu (left) already leads a differentteam that received supportin the first round of federal funding. The goal of that project is to design antiviral medicines that block viral replication.

With our two funded projects, we are working to develop molecules that can target the virus both inside human cells and on the outside to prevent it from getting in, says Sidhu, who is a professor of molecular genetics in the Faculty of Medicine.

Other teams in Canada, as well as in the U.K. and U.S., are looking to infuse Covid-19 survivors blood plasma containing antibodies into patientsto aid their recovery. Plasma transfusion, however, is fraught with challenges, including variability in efficacy between different donors and risk of disease transmission. Synthetic antibodies, on the other hand, represent a defined drug in terms of molecular content, efficacy and dosing regimen.

Rini has previously helped to determine how antibodies bind to and inactivate the SARS virus, the coronavirus that caused the outbreak in Asia more than 15 years ago. Also on the team isAlan Cochrane, a professor in the department of molecular genetics and an HIV virologist with expertise in viral RNA processing.

The antibodies will be engineered to block the so-called S-protein that forms spikes on the virus's surface. The spikes lock on to a protein called ACE2 on the surface of human cells to gain entry. Coating viral particles with synthetic antibodies should prevent the spikes from binding to ACE2.

Sidhu and Rini will also engineer antibodies that bind ACE2 to make it inaccessible to the virus. This type of engineered immunity surpasses the capacity of the bodys natural immune system since antibodies that react against self-proteins have been filtered out. If successful, the approach may obviate worries about viral mutations that can render drugs ineffective to new emerging viral strains becausethe host protein ACE2 does not change over time.

Sidhus team has advanced a technology called phage display to rapidly create and select human antibodies with desired biological properties, including blocking the virussspike protein. Over the last decade, his team has created hundreds of antibodies with therapeutic potential some of which are in clinical development through spin-off companiesand large pharmaceutical firms.

The group has demonstrated success with both approaches for inhibiting viral entry, having developed neutralizing antibodies that target the Ebola virus as well as antibodies that target the human host receptor of hantavirus or hepatitis C. Moreover, other research has shown that antibodies targeting SARS, a related virus whose genetic material is over 80 per cent identical to the one causing COVID-19, can clear infection in cells and mice.

Using phage display, in which tiny bacterial viruses called phages are instructed to create vast libraries of diverse antibodies, the team will select the antibodies that can kill the virus in human cells before testing them on mice and, eventually, patients. Experiments on mice could start within three to six months, Sidhu says.

In addition to creating antibodies tailored to the new virus from scratch, the researchers will also modify existing SARS-blocking antibodies so that they attack COVID-19 and provide an additional route to the development of a therapeutic.

Given the global spread of the virus, its possible that it will become endemic and circulate in the population like seasonal flu. And, like the flu, it could mutate into new strains that will evade acquired immunity and the vaccines that are being developed. By generating a panel of different antibodies, the researchers aim to stay one step ahead of the virus.

Our advances in antibody engineering technologiesand access to the complete genomes of the COVID-19 virus and its relatives provides us with an opportunity to create tailored therapeutic antibodies at a scale and speed that was not possible even a few years ago, says Sidhu.

Ultimately, we aim to optimize methods to the point where the evolution of new drugs will keep pace with the evolution of the virus itself, providing new and effective drugs in response to new outbreaks.

Originally posted here:

Researchers at U of T developing antibodies to 'neutralize' novel coronavirus before it invades cells - News@UofT

What is coronavirus and Covid-19? An explainer – KTVZ

Coronavirus. Just the word strikes fear into our hearts.

Novel coronavirus is the proper term for this brand-new virus wreaking havoc on our unprepared world.

But you can also call this nasty villain by its scientific name: severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2 for short.

Becoming infected with SARS-CoV-2 can trigger a potentially deadly respiratory disease called Covid-19, an illness which presents with three main acute symptoms: fever, a deep, dry cough and a shortness of breath which can become quickly life-threatening. Other symptoms can mimic a cold or the flu.

Covid-19 seems to strike the elderly and immunocompromised the hardest, along with any of us with underlying health conditions such as diabetes, heart and lung disease. But the young shouldnt take anything for granted there have been numerous deaths among people aged 20 to 50, as well as a very few among children.

Covid-19 can also present with mild symptoms very similar to a typical cold or flu or no symptoms at all, which makes controlling the spread of the virus causing Covid-19 very difficult.

All viruses are like zombies they try to take over peoples bodies but they arent really alive. Outside the hosts body they are dormant, surviving without living. Once touched or inhaled and brought inside, their ancient machinery springs into action, using proteins to latch onto and invade human cells.

There they set up shop, producing millions of copies of themselves and causing those cells to rupture. Like the famous scene from the movie Alien, the viral offspring shoot out into the bloodstream, with the goal of invading more and more cells.

As they multiply, humans began to spit them out into the universe with each exhalation, making us contagious days before we begin to cough, sneeze or have diarrhea all symptoms the virus creates to ensure it can leap from human to human, thus ensuring its survival.

This virus zombie invasion comes in all sort of shapes, sizes and genetic strategies. All coronaviruses are covered with pointy spires of protein, giving them the appearance of having a crown or corona hence the name. Coronaviruses use these spikes to latch onto and pierce our cells.

Coronaviruses are part of the RNA brigade of viruses, which are much less stable than their DNA-based comrades. Why is that important? Because instability leads to mistakes in copying genetic code.

That leads to mutations thousands, millions, billions of mutations. Sooner or later, one mutation hits pay dirt and allows the virus to cross the great divide between different species. A few million/billion/trillion more mistakes creates another mutation that allows that virus to spread easily. Now the virus is both in its new host and it is contagious.

Its that type of mutation which gives humanity viruses like SARS-CoV-2.

The animal kingdom is teeming with coronaviruses. They are found in cats and dogs, pigs and cattle, turkey and chickens, mice, rats, rabbits and of course, humans. Insects too.

Some of those coronviruses can cross species, such as between pigs, cats and dogs, but for the most part coronaviruses stay loyal to their original hosts. Until, of course, they become that lucky mutation.

Usually viruses from one animal really dont effectively transmit to other animal species or even to people, said Dr. John Williams, chief of the division of pediatric infectious diseases at the University of Pittsburgh Medical Center Childrens Hospital of Pittsburgh.

So usually if a virus goes from an animal to a human, its sort of dead end. That person gets sick but it doesnt spread further, said Williams, who has studied coronaviruses for decades.

Besides the newly hatched novel coronavirus, there are actually six additional coronaviruses that infect humans four of them cause the common cold.

Two more can be deadly. MERS-CoV is the villian behind Middle East Respiratory Syndrome, or MERS, which has killed over 800 people worldwide since it first appeared in 2012.

SARS-CoV causes a serious form of pneumonia that can also be life-threatening. Globally, it killed 774 people between 2002 and 2004. No other cases have been reported worldwide since. {To put that into context, the death toll of the novel coronavirus since it burst on the scene in December is approaching 40,000).

The coronaviruses that cause MERS and SARS are though to have crossed from mammals to humans, where they mutated to become contagious. MERS-CoV first appeared in Jordon and Saudi Arabia in 2012 and its thought to have crossed over to humans from dromedary camels in Africa, the Middle East and southern Asia.

MERS is extremely deadly, about 30% of people who are infected with MERS will die, Williams said. So the virus got over one of the barriers its able to infect humans, grow in them and cause disease but thankfully it really doesnt spread well person to person, other than very, very close contacts.

SARS has been more difficult to pin down.

Because one of the most common carriers for coronaviruses are bats, its thought that the virus may have started there. Then it supposedly mutated to the masked palm civet, a small cat-like mammal eaten in some parts of China. But even that theory is disputed.

SARS caused death in about 10% of people that became infected and it did spread person to person but not super effectively, Williams said. There werent many people walking around without symptoms or with mild symptoms, who could be spreading it.

This new virus, SARS-CoV-2, has overcome more barriers, Williams added. It spreads easily person to person and a lot of people can have either mild disease or they might not even have symptoms, yet they can have the virus and spread it.

The novel coronavirus appears to have originated in bats. A study published in February found the coronavirus found in bats shared 96% of the same genetic makeup as the novel coronavirus. But it wasnt a direct link, so the bat had to have infected another species, which then infected humans.

Early reports pointed to snakes bought at a wet market in China were people buy live animals to eat. A recent report of the initial cases of coronavirus in China debunks the snake flu theory, reporting that in 13 of the 41 early cases the infected patients had no link to the wet market.

A recent hypothesis claimed the intermediate host was the pangolin, an endangered scaly, ant-eating creature beloved for its meat and scales, which are used in traditional Chinese medicine. But critics have been skeptical, sending genetic scientists back to their labs to continue the search.

At this time, scientists dont know where the novel coronavirus began.

These things are more difficult than [identifying] dinosaurs, because theres no fossil record of a virus, Williams said. For example, the main virus I study, human metapneumovirus, is clearly a virus that has circulated in humans for decades if not a few centuries.

However, when you look at the genetics of the virus, its closest genetic relative is a bird virus, he added. So, did that virus jump to humans way back and become established? Thats what we think. But it isnt impossible that a human virus jumped to birds and became established there.

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What is coronavirus and Covid-19? An explainer - KTVZ

Plasmid Market was Valued at US$ 89.52 million in 2018 and is Estimated to Reach US$ 447.68 Million by 2027, growing at a CAGR of 19.5% over the…

An erudite report of a worldwide Plasmid Market is recently published by Absolute Markets Insights. The statistical report offers an appropriate analysis of recent trends and technological advancements in global regions such as North America, Latin America, Asia-Pacific, Africa, and India. The data further also applies useful tools, methodologies and standard operating procedures carried out by top-level industries to support its analysis. Moreover, it also applies other effective exploratory techniques such as primary and secondary research techniques.

A plasmid is a small, circular piece of deoxyribonucleic acid (DNA), which is all the genetic material found in an organisms chromosomes and replicates independently of chromosomal DNA. Worldwide rising awareness levels about gene therapy across the globe in recent years is fostering the market growth. According to an article published by Human Gene Therapy, the adoption of gene therapy for chronic diseases, which include Alzheimer Disease is high around the world as compared to less severe diseases, namely, attention deficit hyperactivity disorder (ADHD). Gene therapy is a promising treatment option for various diseases such as inherited disorders, some types of cancer, and certain viral infections; and most commonly, gene therapy is an approach to treat the genetic disorders. Rising number of clinical trials related to gene therapy coupled with increasing funding for research and development activities is likely to nourish the global plasmid market during the forecast period. Surging waves of advanced genetic information have marked the advent of gene therapy revolution in the recent decade. The profound knowledge about gene therapy has accelerated the potential of human genetics and disease, therefore paving the way for gene therapy in pharmaceuticals in the 21st century.

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Plasmid Market was Valued at US$ 89.52 million in 2018 and is Estimated to Reach US$ 447.68 Million by 2027, growing at a CAGR of 19.5% over the...

Litecoin, Stellars Lumen, and Trons TRX Daily Analysis 02/04/20 – Yahoo Finance

Litecoin

Litecoin rose by 0.33% on Wednesday. Following on from a 0.41% gain on Tuesday, Litecoin ended the day at $39.33.

A bearish start to the day saw Litecoin slide to a late afternoon intraday low $37.17.

Litecoin fell through the first major support level at $38.55 and the second major support level at $37.95.

Finding support from the broader market, Litecoin rallied to a final hour intraday high $39.50.

While breaking back through the major support levels, the first major resistance level at $39.58 pinned Litecoin back late on.

At the time of writing, Litecoin was up by 0.74% to $39.62. A bullish start to the day saw Litecoin rise from an early morning low $39.12 to a high $39.93 before easing back.

Litecoin left the major support and resistance levels untested early on.

Litecoin would need to steer clear of sub-$39 levels to support another run the first major resistance level at $40.16

Support from the broader market would be needed, however, for Litecoin to break out from the morning high $39.93.

Barring an extended crypto rally, the first major resistance would likely pin Litecoin back on the day.

Failure to avoid sub-$39 levels could see Litecoin slide back into the red.

A fall back through to sub-$38.70 levels would bring the first major support level at $37.83 into play.

Barring a crypto sell-off, however, Litecoin should steer clear of sub-$37 support levels.

Major Support Level: $37.83

Major Resistance Level: $40.16

23.6% FIB Retracement Level: $62

38.2% FIB Retracement Level: $78

62% FIB Retracement Level: $104

Stellars Lumen rose by 1.40% on Wednesday. Following on from a 1.90% gain on Tuesday, Stellars Lumen ended the day at $0.041073.

Tracking the broader market, Stellars Lumen fell to a late afternoon intraday low $0.039138 before finding support.

The sell-off saw Stellars Lumen fall through the first major support level at $0.04016 and second major support level at $0.03940.

A late rebound saw Stellars Lumen rally to a final hour intraday high $0.041140.

While breaking back through the support levels, Stellars Lumen fell short of the first major resistance level at $0.04150.

At the time of writing, Stellars Lumen was down by 0.86% to $0.040718. A mixed start to the day saw Stellars Lumen rise to an early morning high $0.041474 before falling to a low $0.040718.

Stellars Lumen left the major support and resistance levels untested early on.

Story continues

Stellars Lumen would need to move back through the morning high $0.041474 to support a run at the first major resistance level at $0.041760.

Support from the broader market would be needed, however, for Stellars Lumen to break through to $0.04150 levels.

Barring a late morning rebound, resistance at $0.04150 would likely leave Stellars Lumen short of the first major resistance level.

Failure to move back through to $0.04140 levels could see Stellars Lumen struggle throughout the day.

A fall back through to sub-$0.04050 levels would bring the first major support level at $0.03976 into play.

Barring an extended crypto sell-off, however, Stellars Lumen should steer clear of sub-$0.039 support levels.

Major Support Level: $0.03976

Major Resistance Level: $0.04176

23.6% FIB Retracement Level: $0.1051

38% FIB Retracement Level: $0.1433

62% FIB Retracement Level: $0.2050

Trons TRX rose by 0.36% on Wednesday. Following on from a 1.08% gain on Tuesday, Trons TRX ended the day at $0.011642.

Bearish through most of the day, Trons TRX fell to a late afternoon intraday low $0.011161.

Trons TRX slid through the first major support level at $0.01148 and the second major support level at $0.01132.

Finding support late on, Trons TRX broke back through the major support levels to strike an intraday high $0.011688.

In spite of the breakout, Trons TRX fell short of the first major resistance level at $0.01179 on the day.

At the time of writing, Trons TRX was down by 0.05% to $0.011636. It has been a mixed start to the day. Trons TRX rose to an early morning high $0.011783 before falling to a low $0.011590.

Trons TRX left the major support and resistance levels untested.

Trons TRX would need to move back through to $0.01170 levels to bring the first major resistance level at $0.01183 into play.

Support from the broader market would be needed, however, for Trons TRX to break out from the morning high $0.011783.

Barring a broad-based crypto rally, the first major resistance at $0.01183 would likely cap any upside.

Failure to move back through to $0.01170 levels could see Trons TRX fall deeper into the red.

A fall through to sub-$0.01150 levels would bring the first major support level at $0.01131 into play.

Barring an extended crypto sell-off, however, Trons TRX should continue to steer clear of sub-0.011 levels.

Major Support Level: $0.01131

Major Resistance Level: $0.01183

23.6% FIB Retracement Level: $0.0322

38.2% FIB Retracement Level: $0.0452

62% FIB Retracement Level: $0.0663

Please let us know what you think in the comments below

Thanks, Bob

This article was originally posted on FX Empire

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Litecoin, Stellars Lumen, and Trons TRX Daily Analysis 02/04/20 - Yahoo Finance

Latest Litecoin price and analysis (LTC to USD) – Coin Rivet

Litecoin has proven to be one of the most stable cryptocurrencies during the recent chaos and volatility of the past month.

After falling to as low as $25 on 13th March Litecoin bounced back significantly, with it now consolidating just below the $40 level of resistance.

A breakout above $40 would indicate an upcoming 20% rally to the upside with $48 becoming a potential target to the upside.

However, with the market seemingly in a downtrend whats more likely is another sell off that would take Litecoin back to test the $27 level of support.

Litecoin is one of the most well-known cryptocurrencies having been created back in 2013 when it was worth less than $3.

It has, like most cryptocurrencies, endured a turbulent existence with a series of bull and bear markets taking it to new all-time highs and lows.

The most momentous year for Litecoin was 2017 as it sensationally rallied from around $4 to more than $415, marking a staggering 10,000% return within the space of a year.

Since then Litecoin has struggled to sustain a comparable amount of momentum, falling short in its pursuit for a new all time high in 2019, as it failed to break above $150.

Several analysts have suggested that Litecoin could take many by surprise over the next 12 months as it reacts intuitively to Bitcoins halving event in May, which has historically been bullish for all cryptocurrencies.

As block rewards are halved miners need to ensure that overheads are met, which can only be done if the price doubles from what it was pre-halving.

For more news, guides and cryptocurrency analysis, clickhere.

Recently, the Magical Crypto Friends show which is available onYouTubeand features Litecoin founder Charlie Lee discussed the Litecoin Summit 2019.

The show covered the most important discussions in the community. From Litecoin acting as a store of value to new development updates.

Lee confirmed that the project was working on privacy improvements as well. The Litecoin development team is working with the Mimblewimble protocol, specifically the developers behind Grim, with a view to potentially adding the privacy protocol as an extension block.

According to Lee, it would work as follows: Were working with the Grim++ developers to add an implementation of Mimblewimble. It adds an extension block to the Litecoin main-chain. You can transact between chains to use enhanced privacy.

The goal would be to give Litecoin users improved privacy features when transacting.

Litecoin was released in October 2011 by Charlie Lee, a former Google employee. It is a fork of Bitcoin, with the main difference being a smaller block generation time. The protocol also increased the maximum number of coins and implemented a different script-based algorithm.

Litecoin is one of the leading cryptocurrencies and is one of thetop 10 cryptocurrenciesby market capitalisation.

If you want to find out more information about LTC orcryptocurrenciesin general, then use the search box at the top of this page. Heres an article to get you started:

https://coinrivet.com/litecoin-becomes-official-cryptocurrency-of-the-miami-dolphins/

As with any investment, it pays to do some homework before you part with your money. The prices of cryptocurrencies are volatile and go up and down quickly. This page is not recommending a particular currency or whether you should invest or not.

You may be interested in our range ofcryptocurrency guidesalong with the latest cryptocurrencynews.

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Litecoin, Stellars Lumen, and Trons TRX Daily Analysis 01/04/20 – Yahoo Finance

Litecoin

Litecoin rose by 0.41% on Tuesday. Following on from a 5.09% rally on Monday, Litecoin ended the day at $39.15.

A bearish month saw Litecoin slide by 32.58%. The sell-off reversed gains from early in the year to end the quarter down by 4.72%.

A mixed start to the day saw Litecoin rise to an early morning intraday high $39.41 before hitting reverse.

Falling short of the first major resistance level at $40.15, Litecoin slid to an early morning intraday low $38.38.

Steering clear of the first major support level at $37.46, Litecoin recovered to $39 levels late in the day.

At the time of writing, Litecoin was down by 0.77% to $38.85. A bearish start to the day saw Litecoin slide from an early morning high $39.25 to a low $38.45.

Falling short of the major resistance levels, Litecoin tested the first major support level at $38.55 early on.

Litecoin would need to move back through to $39 levels to support another run the first major resistance level at $39.58.

Support from the broader market would be needed, however, for Litecoin to break out from the morning high $39.25.

Barring a broad-based crypto rebound, the first major resistance would likely pin Litecoin back from $40 levels.

Failure to move back through to $39 levels could see Litecoin fall deeper into the red.

A fall back through the first major support level at $38.55 would bring the second major support level at $37.95 into play.

Barring a crypto sell-off, however, Litecoin should steer clear of sub-$37 support levels.

Major Support Level: $38.55

Major Resistance Level: $39.58

23.6% FIB Retracement Level: $62

38.2% FIB Retracement Level: $78

62% FIB Retracement Level: $104

Stellars Lumen rose by 1.90% on Tuesday. Following on from a 6.03% rally on Monday, Stellars Lumen ended the day at $0.040911.

A bearish month saw Stellars Lumen slide by 28.53%. The sell-off reversed gains from early in the year to end the quarter down by 9.36%.

Choppy through the morning, Stellars Lumen fell to a late morning intraday low $0.039987 before finding support.

Steering clear of the first major support level at $0.03828, Stellars Lumen rallied to a late intraday high $0.041330.

Falling short of the first major resistance level at $0.04151, Stellars Lumen eased back to sub-$0.041 levels.

At the time of writing, Stellars Lumen was down by 1.97% to $0.040104. A bearish start to the day saw Stellars Lumen fall from an early morning high $0.040504 to a low $0.039955.

Falling short of the major resistance levels, Stellars Lumen fell through the first major support level at $0.04016.

Story continues

Stellars Lumen would need to move back through to $0.04070 levels to support a run at the first major resistance level at $0.04150.

Support from the broader market would be needed, however, for Stellars Lumen to break out from Mondays high $0.041331.

Barring a broad-based crypto rebound, resistance at $0.041 would likely leave Stellars Lumen short of the first major resistance level.

Failure to move back through to $0.04070 levels could see Stellars Lumen struggle throughout the day.

A fall back through to sub-$0.040 levels would bring the second major support level at $0.03940 into play.

Barring an extended crypto sell-off, however, Stellars Lumen should steer clear of sub-$0.039 support levels.

Major Support Level: $0.04016

Major Resistance Level: $0.04150

23.6% FIB Retracement Level: $0.1051

38% FIB Retracement Level: $0.1433

62% FIB Retracement Level: $0.2050

Trons TRX rose by 1.08% on Tuesday. Following on from a 7.55% rally on Monday, Trons TRX ended the day at $0.011643.

A mixed start to the day saw Trons TRX rise to an early morning high $0.011669 before hitting reverse.

Falling short of the first major resistance level at $0.01202, Trons TRX fell to a mid-morning intraday low $0.011414.

Steering clear of the first major support level at $0.01083, Trons TRX rallied to a late intraday high $0.011738.

Trons TRX fell short of the first major resistance level at $0.01202 before easing back to sub-0.0117 levels.

At the time of writing, Trons TRX was down by 0.76% to $0.011554. A mixed start to the day saw Trons TRX fall to an early morning low $0.011490 before striking a high $0.011602.

Steering clear of the major resistance levels, Trons TRX tested the first major support level at $0.01148 early on.

Trons TRX would need to move back through to $0.01163 levels to bring the first major resistance level at $0.01179 into play.

Support from the broader market would be needed, however, for Trons TRX to break out from Tuesdays high $0.011771.

Barring a broad-based crypto rebound, the first major resistance at $0.01179 would likely cap any upside.

Failure to move back through to $0.01163 levels could see Trons TRX fall deeper into the red.

A fall through the first major support level at $0.01148 would bring the second major support level at $0.01132 into play.

Barring an extended crypto sell-off, however, Trons TRX should steer clear of the third major support level at $0.01101.

Major Support Level: $0.01148

Major Resistance Level: $0.01179

23.6% FIB Retracement Level: $0.0322

38.2% FIB Retracement Level: $0.0452

62% FIB Retracement Level: $0.0663

Please let us know what you think in the comments below

Thanks, Bob

This article was originally posted on FX Empire

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Litecoin, Stellars Lumen, and Trons TRX Daily Analysis 01/04/20 - Yahoo Finance

Litecoin, Stellars Lumen, and Trons TRX Daily Analysis 31/03/20 – Yahoo Finance

Litecoin

Litecoin rallied by 5.09% on Monday. Reversing a 4.68% slide from Sunday, Litecoin ended the day at $38.99.

It was a bullish start to the week. Litecoin rallied from an early morning intraday low $37.10 to a late intraday high $39.79.

Litecoin broke through the first major resistance level at $38.53 to revisit $39 levels before a late pullback.

The second major resistance level at $39.95 limited the upside on the day.

At the time of writing, Litecoin was down by 0.8% to $38.68. A mixed start to the day saw Litecoin rise to an early morning high $39.41 before falling to a low $38.38.

Litecoin left the major support and resistance levels untested early on.

Litecoin would need to move back through to $39 levels to support another run the first major resistance level at $40.15.

Support from the broader market would be needed, however, for Litecoin to break out from Mondays high $39.79.

Barring an extended crypto rally, the first major resistance at $40.15 would likely limit any upside on the day.

Failure to move back through to $39 levels could see Litecoin fall deeper into the red.

A fall back through to sub-$38.60 levels would bring the first major support level at $37.46 into play.

Barring a crypto sell-off, however, Litecoin should steer clear of the second major support level at $35.94.

Major Support Level: $37.46

Major Resistance Level: $40.15

23.6% FIB Retracement Level: $62

38.2% FIB Retracement Level: $78

62% FIB Retracement Level: $104

Stellars Lumen rallied by 6.03% on Monday. Reversing a 5.62% slide from Sunday, Stellars Lumen ended the day at $0.040118.

Tracking the broader market, Stellars Lumen rallied from an early morning intraday low $0.037837 to a late intraday high $0.041070.

Stellars Lumen broke through the first major resistance level at $0.03947 to come up against the second major resistance level at $0.04113.

In spite of a late pullback, Stellars Lumen avoided a return to sub-$0.040 levels.

At the time of writing, Stellars Lumen was up by 0.71% to $0.040404. A mixed start to the day saw Stellars Lumen rise from an early morning low $0.040148 to a high $0.040622.

Stellars Lumen left the major support and resistance levels untested early on.

Story continues

Stellars Lumen would need to move back through the morning high $0.040622 to support a run at the first major resistance level at $0.04151.

Support from the broader market would be needed, however, for Stellars Lumen to break out from Mondays high $0.041070.

Barring an extended crypto rally, the first major resistance level would likely limit any upside.

Failure to move back through the morning high $0.040622 could see Stellars Lumen hit reverse.

A fall back through to sub-$0.040 levels would bring the first major support level at $0.03828 into play.

Barring an extended crypto sell-off, however, Stellars Lumen should steer clear of the second major support level at $0.03644.

Major Support Level: $0.03828

Major Resistance Level: $0.04151

23.6% FIB Retracement Level: $0.1051

38% FIB Retracement Level: $0.1433

62% FIB Retracement Level: $0.2050

Trons TRX rallied by 7.55% on Monday. Reversing a 6.08% slide from Sunday, Trons TRX ended the day at $0.011508.

Bullish throughout the day, Trons TRX rallied from an early morning intraday low $0.010672 to a late intraday high $0.011861.

Trons TRX broke through the first major resistance level at $0.01118 and the second major resistance level at $0.01164.

Falling short of $0.012 levels, Trons TRX fell back through the second major resistance level late in the day.

At the time of writing, Trons TRX was down by 0.81% to $0.011415. A mixed start to the day saw Trons TRX rise to an early morning high $0.011669 before falling to a low $0.011415.

Trons TRX left the major support and resistance levels untested early on.

Trons TRX would need to move back through the morning high $0.011669 to bring the first major resistance level at $0.01202 into play.

Support from the broader market would be needed, however, for Trons TRX to break out from Mondays high $0.011861.

Barring an extended crypto rally, the first major resistance at $0.01202 would likely cap any upside.

Failure to move back through the morning high $0.011669 could see Trons TRX fall deeper into the red.

A fall through to sub-$0.01135 levels would bring the first major support level at $0.01083 into play.

Barring another crypto meltdown, however, Trons TRX should steer clear of the second major support level at $0.01016.

Major Support Level: $0.01083

Major Resistance Level: $0.01202

23.6% FIB Retracement Level: $0.0322

38.2% FIB Retracement Level: $0.0452

62% FIB Retracement Level: $0.0663

Please let us know what you think in the comments below

Thanks, Bob

This article was originally posted on FX Empire

Here is the original post:

Litecoin, Stellars Lumen, and Trons TRX Daily Analysis 31/03/20 - Yahoo Finance